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Search Results for " cholinergic "

77

抑制剂 & 化合物

12

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T11861	LM11A-31 dihydrochloride	Others	Others
	LM11A-31 dihydrochloride 是一种具有高血脑屏障通透性的氨基酸衍生物，能阻断 p75 介导的细胞死亡。它是一种 p75NTR(神经营养蛋白受体 p75) 非肽调节剂，是口服有效的 proNGF 拮抗剂。它可以逆转中晚期的阿尔茨海默氏病小鼠模型中的胆碱能神经突营养不良。
T0229	Rivastigmine SDZ-ENA 713,卡巴拉汀,S-Rivastigmine,Exelon,利凡斯的明	AChE	Neuroscience
	Rivastigmine (Exelon) 是具有口服活性的、有效的、可透过血脑屏障的胆碱酯酶抑制剂，可抑制丁酰胆碱酯酶和乙酰胆碱酯酶，IC50分别为 0.037 μM 和 4.15 μM。它是一种拟副交感神经剂或胆碱能剂，用于研究轻度至中度阿尔茨海默氏型痴呆和帕金森氏病引起的痴呆。
T1628	Rivastigmine tartrate SDZ-ENA 713,ENA 713,酒石酸卡巴拉汀	AChR; AChE	Neuroscience
	Rivastigmine tartrate (SDZ-ENA 713) 是一种具有口服活性的、可透过血脑屏障的胆碱酯酶抑制剂，能够抑制丁酰胆碱酯酶和乙酰胆碱酯酶。它是一种拟副交感神经剂或胆碱能剂，用于研究轻度至中度阿尔茨海默氏型痴呆和帕金森氏病引起的痴呆。
T0236	Azatadine dimaleate 马来酸阿扎他啶,SCH10649,马来酸阿扎他定,Azatadine Maleate	5-HT Receptor; AChR; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Azatadine dimaleate (SCH10649) 是组胺和胆碱能抑制剂，IC50分别为 6.5 和 10 nM。
T5655	mAChR-IN-1 hydrochloride	AChR	Neuroscience
	mAChR-IN-1 hydrochloride 是一种毒蕈碱胆碱能受体抑制剂，IC50值为17nM。
T26778	Besipirdine HP 749 free base,P-867493,P867493,HP 749,HP749,P 867493	Sodium Channel; Adrenergic Receptor	GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Besipirdine (HP 749 free base)是一种非受体依赖性拟胆碱化合物，具有α-肾上腺素能活性和心血管活性。Besipirdine 抑制电压依赖性钠钾通道，抑制生物胺的摄取。Besipirdine 可减少大鼠的时间表诱导的烦渴，增强中枢神经系统中的胆碱能和肾上腺素能神经传递。
T34114	Posatirelin BRN 6006446,Posatirelinum,BRN-6006446,RGH-2202,BRN6006446	AChR	Neuroscience
	Posatirelin (BRN6006446) 是一种对单胺能和胆碱能系统具有调节活性和神经营养作用的合成肽，可用于研究血管性痴呆。
T27404	GAT107 GAT 107,GAT-107	AChR	Neuroscience
	GAT107 是一种新型有效的 α7 烟碱胆碱能受体变构激动剂和调节剂，具有抗炎活性，可逆转小鼠神经疼痛模型中的伤害感受。
T0169	Nefiracetam DM9384,奈非西坦,DZL-221	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Nefiracetam (DM9384) 是一种 GABA 能、胆碱能和单胺能神经元系统增强剂，用于治疗 Ro 5-4864 引起的抽搐。
T2571	Benactyzine hydrochloride Neuroleptone,胃复康,盐酸贝那替嗪,Tranquilline,Amitakon	AChR; AChE	Neuroscience
	Benactyzine hydrochloride (Neuroleptone) 是丁酰胆碱酯酶抑制剂，其Ki=0.010 mM。
T10914L	Cyclodrine Cyclopent	AChR	Neuroscience
	Cyclodrine (Cyclopent) 是一种胆碱能 (毒蕈碱，烟碱) 受体 (mAChR 和 nAChR) 拮抗剂。
T10914	Cyclodrine hydrochloride	AChR	Neuroscience
	Cyclodrine hydrochloride 是一种胆毒蕈碱受体（mAChR）和烟碱受体（nAChR）双重拮抗剂，可以用于研究神经系统相关疾病。
T21439	Tacrine 他克林,CS 12602,Tacrinum,Tetrahydroaminocrine	AChR	Neuroscience
	Tacrine (CS 12602) 一种间接胆碱能激动剂和中枢作用的抗胆碱酯酶。它被批准用于治疗阿尔茨海默病。
T6707	Tiotropium Bromide hydrate BA-679 BR hydrate,BA 679BR,噻托溴铵一水合物	AChR	Neuroscience
	Tiotropium Bromide hydrate (BA-679 BR hydrate) 是长效的毒蕈碱受体拮抗剂，可用于治疗慢性阻塞性气道疾病 (COPD)。
T50047	1-(3,4-dihydroxyphenyl)-2-(dimethylamino)ethan-1-one hydrochloride	Others	Others
	1-(3,4-dihydroxyphenyl)-2-(dimethylamino)ethan-1-one hydrochloride 是一种胆碱能制剂，抑制胆碱代谢，从而导致大脑中乙酰胆碱水平的增加，进而增强认知功能和记忆。
T26174	SAK3 SAK 3,SAK-3	Calcium Channel; AChR	Membrane transporter/Ion channel; Metabolism; Neuroscience
	SAK3 是一种新型的 nAChR 活性调节剂，可增强 T 型电压门控 Ca2+ 通道 (T-VGCC) 的活性，对 Cav3.1 和 Cav3.3 T 型 Ca2+ 通道电流均有增强作用。SAK3 对人神经母细胞瘤 SH-SY5Y 细胞中东莨菪碱诱导的胆碱能功能障碍有神经保护作用。SAK3 可用于研究记忆缺陷和阿尔茨海默病。
T26778L	Besipirdine hydrochloride HP 749 hydrochloride,Besipirdine hydrochloride（119257-34-0 Free base)	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Besipirdine hydrochloride 是一种非受体依赖性拟胆碱化合物，具有α-肾上腺素能活性和心血管活性。Besipirdine hydrochloride 抑制电压依赖性钠钾通道，抑制生物胺的摄取。Besipirdine hydrochloride 可减少大鼠的时间表诱导的烦渴，增强中枢神经系统中的胆碱能和肾上腺素能神经传递。
T1281	Tropicamide Ro 1-7683,托吡卡胺	AChR	Neuroscience
	Tropicamide (Ro 1-7683) 是一种选择性的 M4毒蕈碱乙酰胆碱受体拮抗剂，作为滴眼剂使用时，会产生短效瞳孔扩张和睫状肌麻痹。
T1568	Amoxapine 阿莫沙平,CL-67772	GlyT	Neuroscience
	Amoxapine (CL-67772) 是一种dibenzoxazepine 家族的四环抗抑郁药，常被归类为仲胺三环类抗抑郁药。
TP1902L1	G-Protein antagonist peptide acetate	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	G-Protein antagonist peptide acetate 是一种 substance P 相关肽，可抑制 G 蛋白与其受体的结合。G-Protein antagonist peptide acetate 竞争性和可逆性地抑制毒蕈碱型乙酰胆碱受体 M2 (M2 muscarinic receptor) 对 Gi 或 Go 的激活，并通过 β-肾上腺素受体抑制 Gs 的激活。
T0976	Propoxur 残杀威,Aprocarb,Propoxure,Baygon	AChR; Antifungal	Microbiology/Virology; Neuroscience
	Propoxur (Propoxure) 是一种氨基甲酸酯类杀虫剂，用于控制蟑螂、苍蝇、蚊子以及草坪和草坪昆虫。
TP2309	NEUROTENSIN TFA (39379-15-2 free base) Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH TFA（55508-42-4 free base),NEUROTENSIN TFA,神经加压素	Others	Others
	Neurotensin TFA (39379-15-2 free base) 是一种内源性 13 个氨基酸的神经肽，具有显着的阿片类非依赖性镇痛作用。它在大脑中充当神经递质，在肠道中充当激素，也充当神经调节剂。由于它与多种神经递质系统如多巴胺能、血清素能、谷氨酸能、GABA 能和胆碱能系统。它具有作为人体代谢物、有丝分裂原、神经递质和创伤的作用。
T34223	Quilostigmine HP 290,NXX 066,NXX-066
	Quilostigmine is a cholinergic.
T70220	Tazomeline citrate
	Tazomeline citrate is used for alzheimer's disease treatment (Cholinergic Agonist).
T71050	U 80816B
	U 80816B is a cholinergic direct agonist.
T22511	4-DAMP	Others	Others
	M3 cholinergic receptor antagonist
T28742	Securinine mononitrate Securinan-11-one nitrate
	Securinine mononitrate is a cholinergic agent and an antagonist of gamma-aminobutyric acid A (GABAA) receptor.
T10224	ABT-418 hydrochloride	Others	Others
	ABT-418 hydrochloride is a selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. It activates cholinergic channel and can be used for the research of Alzheimer's disease.
T20522	Acetylcholine perchlorate AI351678,AI3-51678,AI3 51678
	Acetylcholine perchlorate is the perchlorate salt of acetylcholine. Acetylcholine, an endogenous neurotransmitter at cholinergic synapses, could amplify the action potential of the sarcolemma following by inducing muscle contractions.
T6597L	Mosapride citrate dihydrate GR-107719-B,Mosapride Citrate,GR 107719 B,AS 4370,AS-4370,TAK-370
	Mosapride Citrate is a 5-HT4 receptor agonist used to stimulate gastrointestinal motility via acetylcholine. Mosapride Citrate facilitates acetylcholine release from the enteric cholinergic neurons.
T33634	Neopterin, L-erythro- Neopterin, L-(-)-,L-Neopterin,L-Erythro-neopterin
	Neopterin, L-erythro- can be used as a cholinergic receptor.
T71531	Metamizil hydrochloride
	Metamizil hydrochloride is a cholinolytic agent -- an agent that blocks the transmission of excitation from cholinergic nerve fibers -- and an antagonist of the mediator acetylcholine.
T26553	Aclatonium Napadisilate Acaltonium napadisilate
	Aclatonium Napadisilate, a cholinergic agonist, has been shown to stimulates endocrine and exocrine pancreatic secretion.
T22593	Azatadine	Others	Others
	Azatadine is histamine and cholinergic inhibitor (IC50: 6.5 nM and 10 nM, respectively).
T69234	Piperilate HCl
	Piperilate HCl is an antispasmodic, antimuscarinic agent. It is a muscarinic cholinergic receptor antagonist.
T32833	Lobeline, (+)- (+)-Lobeline
	Lobeline, (+)- is an alkaloid that has actions similar to nicotine on nicotinic cholinergic receptors but is less potent. It has been proposed for a variety of therapeutic uses including in respiratory disorders, peripheral vascular disorders, insomnia, a
T34750	Sut 8701 Sut8701,Sut-8701
	Sut 8701 is a cholecystokinin analog that prevents cholinergic degeneration in the rat cerebral cortex following basal forebrain lesioning and can slow down the degenerative processes in Alzheimer's disease.
T15743	Levomepromazine Methotrimeprazine	Others	Others
	Methotrimeprazine is an orally available neuroleptic agent. It is commonly used to relieve nausea and vomiting in palliative care settings. Levomepromazine has antagonist actions at multiple neurotransmitter receptor sites, including cholinergic, dopamine
T29203	Zanapezil fumarate TAK 147,TAK147,TAK-147
	Zanapezil is an acetylcholinesterase (AChE) inhibitor. Zanapezil increases choline acetyltransferase activity in cultured rat septal cholinergic neurons.
T68289	Nicotine hemicitrate
	Nicotine hemicitrate is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
T68439	Nicotine dicitrate
	Nicotine dicitrate is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
T5476	mAChr-in-1	AChR	Neuroscience
	mAChR-IN-1 是一种毒蕈碱胆碱能受体拮抗剂，IC50为17 nM。
T22435	Tacrine hydrochloride 四氢氨基吖啶,盐酸他克林,Tacrine HCl	Others	Others
	Tacrine is a indirect cholinergic agonist and centrally acting anticholinesterase. Tacrine hydrochloride hydrate is an inhibitor of acetyl (AChE) and butyryl-cholinestrase (BChE) with IC50s of 31 nM and 25.6 nM, respectively.
T78109	(Ala13)-Apelin-13 TFA
	'(Ala13)-Apelin-13 TFA' 为高效的APJ受体拮抗剂，能够通过迷走神经胆碱能通路抑制胃动力。
T8443L	MCI-225 hydrochloride hydrate AA-10021,AA10021,MCI225,DDP-225,AA-10025,AA-10026
	MCI-225 is a norepinephrine reuptake/5-HT3/5-HT reuptake inhibitor. MCI-225 could be effective in the treatment of senile dementia of the Alzheimer type, which is accompanied with both deficit in the BF-cortex cholinergic neuron and cerebral glucose hypom
T21464	Methiocarb Mercaptodimethur,Mesurol
	Methiocarb, a carbamate pesticide, is used as an insecticide, acaricide, bird repellent, and molluscicide. Methiocarb stimulates cholinergic by inhibiting reversibly acetylcholinesterase activity, making methiocarb a potent neurotoxin.
T20131	Cevimeline hydrochloride 盐酸西维美林,Cevimeline HCl,Evoxac
	Cevimeline HCl is an agonist of cholinergic that binds to muscarinic receptors. Muscarinic agonists in sufficient dosage can enhance the secretion of exocrine glands, such as salivary and sweat glands.
T11273	Fenpiverinium D3 bromide	Others	Others
	Fenpiverinium bromide has anti-cholinergic and anti-spasmodic effects.Fenpiverinium D3 bromide is a deuterium labeled Fenpiverinium bromide.
T69804	Nicotine monomethiodide
	Nicotine monomethiodide is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
T69439	Nicotine tartrate
	Nicotine tartrate is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.

化合物

LM11A-31 dihydrochloride

Cat.No: T11861

Target: Others

Cat.No: T0229

Synonym: SDZ-ENA 713,卡巴拉汀,S-Rivastigmine,Exelon,利凡斯的明

Target: AChE

Rivastigmine tartrate

Cat.No: T1628

Synonym: SDZ-ENA 713,ENA 713,酒石酸卡巴拉汀

Target: AChR, AChE

Azatadine dimaleate

Cat.No: T0236

Synonym: 马来酸阿扎他啶,SCH10649,马来酸阿扎他定,Azatadine Maleate

Target: 5-HT Receptor, AChR, Histamine Receptor

mAChR-IN-1 hydrochloride

Cat.No: T5655

Target: AChR

Cat.No: T26778

Synonym: HP 749 free base,P-867493,P867493,HP 749,HP749,P 867493

Target: Sodium Channel, Adrenergic Receptor

Cat.No: T34114

Synonym: BRN 6006446,Posatirelinum,BRN-6006446,RGH-2202,BRN6006446

Target: AChR

Cat.No: T27404

Synonym: GAT 107,GAT-107

Target: AChR

Cat.No: T0169

Synonym: DM9384,奈非西坦,DZL-221

Target: GABA Receptor

Benactyzine hydrochloride

Cat.No: T2571

Synonym: Neuroleptone,胃复康,盐酸贝那替嗪,Tranquilline,Amitakon

Target: AChR, AChE

Cat.No: T10914L

Synonym: Cyclopent

Target: AChR

Cyclodrine hydrochloride

Cat.No: T10914

Target: AChR

Cat.No: T21439

Synonym: 他克林,CS 12602,Tacrinum,Tetrahydroaminocrine

Target: AChR

Tiotropium Bromide hydrate

Cat.No: T6707

Synonym: BA-679 BR hydrate,BA 679BR,噻托溴铵一水合物

Target: AChR

1-(3,4-dihydroxyphenyl)-2-(dimethylamino)ethan-1-one hydrochloride

Cat.No: T50047

Target: Others

Cat.No: T26174

Synonym: SAK 3,SAK-3

Target: Calcium Channel, AChR

Besipirdine hydrochloride

Cat.No: T26778L

Synonym: HP 749 hydrochloride,Besipirdine hydrochloride（119257-34-0 Free base)

Target: Adrenergic Receptor

Cat.No: T1281

Synonym: Ro 1-7683,托吡卡胺

Target: AChR

Cat.No: T1568

Synonym: 阿莫沙平,CL-67772

Target: GlyT

G-Protein antagonist peptide acetate

Cat.No: TP1902L1

Target: Adrenergic Receptor

Cat.No: T0976

Synonym: 残杀威,Aprocarb,Propoxure,Baygon

Target: AChR, Antifungal

NEUROTENSIN TFA (39379-15-2 free base)

Cat.No: TP2309

Synonym: Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH TFA（55508-42-4 free base),NEUROTENSIN TFA,神经加压素

Target: Others

Cat.No: T34223

Synonym: HP 290,NXX 066,NXX-066

Tazomeline citrate

Cat.No: T70220

Cat.No: T71050

Cat.No: T22511

Target: Others

Securinine mononitrate

Cat.No: T28742

Synonym: Securinan-11-one nitrate

ABT-418 hydrochloride

Cat.No: T10224

Target: Others

Acetylcholine perchlorate

Cat.No: T20522

Synonym: AI351678,AI3-51678,AI3 51678

Mosapride citrate dihydrate

Cat.No: T6597L

Synonym: GR-107719-B,Mosapride Citrate,GR 107719 B,AS 4370,AS-4370,TAK-370

Neopterin, L-erythro-

Cat.No: T33634

Synonym: Neopterin, L-(-)-,L-Neopterin,L-Erythro-neopterin

Metamizil hydrochloride

Cat.No: T71531

Aclatonium Napadisilate

Cat.No: T26553

Synonym: Acaltonium napadisilate

Cat.No: T22593

Target: Others

Cat.No: T69234

Cat.No: T32833

Synonym: (+)-Lobeline

Cat.No: T34750

Synonym: Sut8701,Sut-8701

Levomepromazine

Cat.No: T15743

Synonym: Methotrimeprazine

Target: Others

Zanapezil fumarate

Cat.No: T29203

Synonym: TAK 147,TAK147,TAK-147

Nicotine hemicitrate

Cat.No: T68289

Nicotine dicitrate

Cat.No: T68439

Cat.No: T5476

Target: AChR

Tacrine hydrochloride

Cat.No: T22435

Synonym: 四氢氨基吖啶,盐酸他克林,Tacrine HCl

Target: Others

(Ala13)-Apelin-13 TFA

Cat.No: T78109

MCI-225 hydrochloride hydrate

Cat.No: T8443L

Synonym: AA-10021,AA10021,MCI225,DDP-225,AA-10025,AA-10026

Cat.No: T21464

Synonym: Mercaptodimethur,Mesurol

Cevimeline hydrochloride

Cat.No: T20131

Synonym: 盐酸西维美林,Cevimeline HCl,Evoxac

Fenpiverinium D3 bromide

Cat.No: T11273

Target: Others

Nicotine monomethiodide

Cat.No: T69804

Nicotine tartrate

Cat.No: T69439

Cat. No.	Product Name	Target	Signaling Pathways
T3026	(-)-Huperzine A HupA,石杉碱,Huperzine A,石杉碱甲	Apoptosis; AChR; AChE; iGluR	Apoptosis; Membrane transporter/Ion channel; Neuroscience
	(-)-Huperzine A (HupA) 是从中国梅花苔中分离得到的一种生物碱，具有神经保护活性。它是高特异性可逆的，具有血脑屏障渗透性的一种乙酰胆碱酯酶抑制剂，其IC50值为 82 nM。它也是 N-甲基-D-天冬氨酸受体的非竞争性拮抗剂，可研究神经退行性疾病，如阿尔茨海默病。
T3767	Polygalacic acid Virgaureagenin G,毛果一枝黄花皂苷元G,远志酸	MMP; AChR; AChE	Neuroscience; Proteases/Proteasome
	Polygalacic acid (Virgaureagenin G) 是一种从远志 Polygala tenuifolia Willd 根中分离出来的三萜，可抑制 MMP 表达。它对认知障碍有显著的神经保护作用，PA 通过抑制乙酰胆碱酯酶活性，增加胆碱乙酰转移酶活性，提高海马和额皮质中的乙酰胆碱水平来提高胆碱能系统反应性。它可以用于骨关节炎相关研究。
T6S0109	Sipeimine Kashmirine,西贝母碱,Imperialine,西贝碱	Others	Others
	Sipeimine (Kashmirine) 是一种天然产物，从平贝母中分离得到。
TN1236	3',4',7-Trihydroxyisoflavone	MAPK; JNK	MAPK
	3',4',7-Trihydroxyisoflavone 是大豆异黄酮大豆苷元衍生物，是 Cot (Tpl2/MAP3K8) 和 MKK4 抑制剂，具有抗癌、抗血管生成和自由基清除特性。3',4',7-Trihydroxyisoflavone 通过调节小鼠胆碱能功能和BDNF信号通路增强记忆作用，可改善因内源性或外源性糖皮质激素而受损的皮肤屏障功能，可用于研究特应性皮炎。
T1221	Acetylcholine chloride ACh chloride,Pilofrin,氯化乙酰胆碱	Calcium Channel; Endogenous Metabolite; AChR	Membrane transporter/Ion channel; Metabolism; Neuroscience
	Acetylcholine chloride (Pilofrin) 是一种神经递质，是胆碱能激动剂，通过刺激烟碱乙酰胆碱受体调节多巴胺能神经元活性，在体外抑制 p53 突变肽的聚集。
T9113	Myristicin Myristicine,肉豆蔻醚	IL Receptor; Anti-infection; BCL; P450; PARP; 5-HT Receptor; Caspase; GABA Receptor; NO Synthase	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Myristicin (Myristicine) 是一种在香料和伞形植物中发现的天然产物。肉豆蔻素具有抗胆碱能、抗菌和肝保护作用，还具有抗炎作用，其通过钙途径抑制dsrna 刺激的巨噬细胞中的NO、细胞因子、趋化因子和生长因子。Myristicin 可以诱导细胞凋亡，其特征是改变线粒体膜电位、细胞色素c 释放、Caspase-3激活、parp 切割和DNA 断裂。
T1437	D-Panthenol D-泛醇,D-Pantothenyl alcohol,Ilopan,Dexpanthenol,Pantothenol	Endogenous Metabolite	Metabolism
	D-Panthenol (D-Pantothenyl alcohol) 是 D-pantothenic acid 和胆碱能剂的酒精类似物。D-Panthenol 作为乙酰化反应所必需的辅酶A的前体，参与乙酰胆碱的合成。虽然 D-Panthenol 作用的确切机制尚不清楚，但它可能增强乙酰胆碱的作用。D-Panthenol 作用于胃肠道，增加下肠蠕动。它也适用于局部皮肤，以缓解瘙痒和促进愈合。
T4S0969	Obtusifolin 决明蒽醌,决明蒽醌；美决明子素	Antioxidant; NF-κB	NF-κB; oxidation-reduction
	Obtusifolin 是分离自决明子的种子中，能够抑制NF-kB 通路，调节气道上皮细胞中 MUC5AC 粘蛋白的基因表达和产生。它通过靶向甲状旁腺激素相关蛋白来抑制邻苯二甲酸酯诱导的乳腺癌骨转移。
T2S2363	Corydine	IL Receptor; Antifection	Immunology/Inflammation; Microbiology/Virology
	Corydine is the adrenolytic and weak cholinergic agent, it shows antimicrobial, and antineoplastic activities. Corydine shows irritant and respiratory stimulant and CNS depressant activities. Injected intravenously in rabbits corydine produced an initial
T22357	Lobeline sulfate 硫酸山梗菜碱,Lobelin sulphate	Others	Others
	Lobelin sulphate is an alkaloid that has actions similar to nicotine on nicotinic cholinergic receptors but is less potent. It has a variety of therapeutic uses including in insomnia, and smoking cessation, peripheral vascular disorders, respiratory disor
TN3472	Axillaridine A	Others	Others
	Axillaridine A is a new cholinesterase inhibitors, it may act as potential leads in the discovery of clinically useful inhibitors for nervous-system disorders, particularly by reducing memory deficiency in Alzheimer's disease patients by potentiating and
T81072	Suffruticosol A
	Suffruticosol A是一种从P. lactiflora种子中分离得到的神经保护剂，能够逆转由Scopolamine诱导的细胞神经退行性损伤。该化合物还能改善海马体胆碱能缺陷并部分增强BDNF信号传导，从而在Scopolamine诱导模型中显示出改善神经功能的作用，可恢复小鼠记忆与认知行为。

天然产物

(-)-Huperzine A

Cat.No: T3026

Synonym: HupA,石杉碱,Huperzine A,石杉碱甲

Target: Apoptosis, AChR, AChE, iGluR

Polygalacic acid

Cat.No: T3767

Synonym: Virgaureagenin G,毛果一枝黄花皂苷元G,远志酸

Target: MMP, AChR, AChE

Cat.No: T6S0109

Synonym: Kashmirine,西贝母碱,Imperialine,西贝碱

Target: Others

3',4',7-Trihydroxyisoflavone

Cat.No: TN1236

Target: MAPK, JNK

Acetylcholine chloride

Cat.No: T1221

Synonym: ACh chloride,Pilofrin,氯化乙酰胆碱

Target: Calcium Channel, Endogenous Metabolite, AChR

Cat.No: T9113

Synonym: Myristicine,肉豆蔻醚

Target: IL Receptor, Anti-infection, BCL, P450, PARP, 5-HT Receptor, Caspase, GABA Receptor, NO Synthase

Cat.No: T1437

Synonym: D-泛醇,D-Pantothenyl alcohol,Ilopan,Dexpanthenol,Pantothenol

Target: Endogenous Metabolite

Cat.No: T4S0969

Synonym: 决明蒽醌,决明蒽醌；美决明子素

Target: Antioxidant, NF-κB

Cat.No: T2S2363

Target: IL Receptor, Antifection

Lobeline sulfate

Cat.No: T22357

Synonym: 硫酸山梗菜碱,Lobelin sulphate

Target: Others

Cat.No: TN3472

Target: Others

Suffruticosol A

Cat.No: T81072

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