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Search Results for " antithrombotic "

64

抑制剂 & 化合物

11

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T4980	Betrixaban maleate	Factor Xa	Metabolism
	Betrixaban maleate 是一种非维生素 K 口服抗凝剂，其作用是由 Xa 因子的竞争性和可逆抑制作用驱动的。
T3536	AZD1283	P2Y Receptor	GPCR/G Protein; Neuroscience
	AZD1283是P2Y12受体拮抗剂，EC50为3.0 ug/kg/min，结合的IC50为11 nM。它剂量依赖性地诱导血流量增加和抑制 ADP 诱导的血小板聚集，抗血栓形成的 ED50 值分别为 3.0 和 10 μg/kg/min。
T4132	BPTU BMS-646786	P2Y Receptor	GPCR/G Protein; Neuroscience
	BPTU (BMS-646786) 是一种非核苷酸类P2Y1受体变构拮抗剂，能够阻断位于胃肠道神经肌肉接头的 P2Y1受体，具有抗血栓活性。
T0435	Sulfinpyrazone (+/-)-Sulfinpyrazone,G-28315,苯磺保泰松,NSC 75925	COX	Immunology/Inflammation; Neuroscience
	Sulfinpyrazone (NSC-75925) 是一种口服有效的尿酸剂，具有抗血栓和血小板抑制作用。它可作用于慢性和间歇性痛风性关节炎。
T0389	Dabigatran etexilate 达比加群酯,BIBR 1048	Thrombin	Proteases/Proteasome
	Dabigatran etexilate (BIBR 1048) 是一种 Dabigatran 前药，具有口服活性。它具有抗凝作用，能够预防心房颤动引起的静脉血栓栓塞和中风。
T4190	Ticlopidine PCR 5332,Ticlid,噻氯匹定	ATPase; Adiponectin receptor	GPCR/G Protein; Membrane transporter/Ion channel
	Ticlopidine (PCR 5332) 是抗血栓前药。它是CYP2C19人肝细胞色素的抑制剂，抑制 CYP2C9 及 CYP3A4。他是变构CD39的非竞争性抑制剂，能够阻断 NTPDase 同工酶，对NTPDase2和NTPDase3的IC50分别为 170 µM 和 149 µM。
T31206	Darexaban YM 150,Darexaban, Tanexaban,YM150	Factor Xa	Metabolism
	Darexaban (Tanexaban, YM-150) 是选择性的、口服具有活力的 Xa 因子 (FXa) 抑制剂，IC50=54.6 nM。它对其他相关丝氨酸蛋白酶(如胰蛋白酶、凝血酶和激肽释放酶)具有高选择性。它具有抗凝和抗血栓形成作用。
T6182	Tirofiban L700462,Aggrastat,替罗非班,MK383	Integrin	Cytoskeletal Signaling
	Tirofiban (L700462) 是一种非肽类选择性 GPIIb/IIIa 拮抗剂，IC50 为 9 nM，可抑制血小板聚集。
T5133	Dabigatran Etexilate Mesylate 甲磺酸达比加群酯,BIBR 1048MS,Dabigatran etexilate methanesulfonate	Thrombin	Proteases/Proteasome
	Dabigatran Etexilate Mesylate (BIBR 1048MS) 是一种口服具有活性的 Dabigatran 前药，具有抗凝作用，能够预防心房颤动引起的静脉血栓栓塞和中风。
T2537	Tirofiban hydrochloride monohydrate Tirofiban Hydrochloride,盐酸替罗非班水合物,MK-383 Hydrochloride,盐酸替罗非班	ATPase; Integrin	Cytoskeletal Signaling; Membrane transporter/Ion channel
	Tirofiban hydrochloride monohydrate (MK-383 Hydrochloride) 是一种非肽类糖蛋白IIb/IIIa 的拮抗剂。
T0182L	Clopidogrel hydrogen sulfate 硫酸氢氯吡格雷,(S)-(+)-Clopidogrel hydrogen sulfate,(S)-(+)-Clopidogrel bisulfate,SR-25990C,Clopidogrel,硫酸氯吡格雷	P450; P2Y Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Clopidogrel hydrogen sulfate ((S)-(+)-Clopidogrel bisulfate) 是一种抗血小板药物，可防止血栓形成。它抑制 CYP2B6和 CYP2C19，IC50分别为 18.2 和 524 nM。它是一种选择性的高亲和力 P2Y12 受体拮抗剂，可抑制纤维蛋白原与血小板的结合以及血小板的粘附和聚集。
T2368	Edoxaban Tosylate Monohydrate DU-176b,DU-176b tosylate Monohydrate,Lixiana,Edoxaban,依度沙班对甲苯磺酸盐一水化合物	Factor Xa; Thrombin	Metabolism; Proteases/Proteasome
	Edoxaban Tosylate Monohydrate (DU-176b tosylate Monohydrate) 是口服具有活力的 factor Xa 选择性抑制剂。它是一种抗凝剂，可用于预防中风，是一种凝血酶和凝血因子 IXaβ (FIXa) 的弱抑制剂，对 FXa 的选择性超过 10000 倍。它具有抗血栓形成的特性，可用于血栓栓塞性疾病的研究。
T13210	Trombodipine PCA-4230	Others	Others
	Trombodipine is an agent of antithrombotic.
T67991	Iliparcil	Others	Others
	Iliparcil 是一种具有口服活性的抗血栓化合物。
T4076	Fondaparinux sodium Natural heparin pentasaccharide Sodium,Fondaparin sodium,磺达肝素(癸)钠,磺达肝癸钠,SR-90107A,Arixtra	Factor Xa	Metabolism
	Fondaparinux sodium (SR-90107A) 是抗凝血酶依赖性的 factor Xa 抑制剂。
T25741	Linotroban HN 11500,CL-871502	PPAR	DNA Damage/DNA Repair; Metabolism
	Linotroban（CL-871502）是一种有效的选择性血栓素（TXA2）受体拮抗剂，具有抗血栓活性。
T80792	WAY-639228	Others	Others
	WAY-639228-A 具有潜在的抗血栓和抗凝活性，可用于研究脑血栓。
T27920	LY 517717 LY-517717,LY517717	Factor Xa	Metabolism
	LY 517717 是一种具有口服活性的凝血因子 Xa 抑制剂，具有抗血栓活性，可用于研究静脉血栓栓塞（VTE）。
T27318	Fidexaban CI-1031,BX-807834,PD-200022,CI1031,BX807834,ZK-807834	Factor Xa	Metabolism
	Fidexaban (CI1031) 是一种新型、强效、选择性和口服活性 Xa 因子抑制剂，在多种测定中均显示出抗血栓活性。
T17025	Tecarfarin ATI-5000,ATI-5923	Others	Others
	Tecarfarin (ATI-5923) 是一种具有口服活性和有效性的维生素 K 环氧化物还原酶 (VKOR) 拮抗剂和大麻素-1受体反向激动剂，具有抗血栓形成活性，可减轻小鼠的腹痛并增加肠道转运。
T9620	Sodium Tetradecyl Sulfate	Others	Others
	Sodium Tetradecyl Sulfate 是洗涤剂硬化剂，常用于静脉曲张及食管静脉的治疗。
T3757	NQ301	Thrombin; Platelet aggregation	Others; Proteases/Proteasome
	NQ301 是一种抗血栓剂，能够抑制胶原蛋白激发的兔血小板聚集，IC50=10 mg/mL。
T24542	NP-313 NP 313,NSC 4264,NSC-4264,NSC4264
	NP-313 (NSC-4264) 是一种有效的抗血栓剂，对血栓素 A 2 合成和选择性抑制由 SOCC 介导的 Ca 2+ 内流有抑制作用，可以抑制血小板的聚集和活化。
T3469	PCI-27483 PCI27483	Others	Others
	PCI-27483 是一种FVIIa/tissue factor 抑制剂，具有抗肿瘤的作用。
T8580	Bupranolol	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Bupranolol 是竞争性的、口服活性的、非选择性的β-adrenoceptor 拮抗剂，无固有的拟交感神经活性。
T11825	LCB-2853	PPAR	DNA Damage/DNA Repair; Metabolism
	LCB-2853 是一种有效的血栓素 A2/前列腺素 H2 （TXA2/PGH2）受体拮抗剂，具有抗血小板聚集、抗血管痉挛和抗血栓作用。
T63966	BMS-986141 UDM-003183	Protease-activated Receptor	GPCR/G Protein
	BMS-986141(UDM-003183) 是一种具有口服活性的选择性和高效性的凝血酶受体蛋白酶激活受体-4 (protease-activated receptor-4 (PAR-4)) 拮抗剂，其 IC50 值为 0.4 nM。BMS-98614 表现出显著的抗血栓作用。
T16328	Nitroaspirin 2-乙酰氧基苯甲酸-3-硝酸甲基苯酯,NCX 4016	Apoptosis; COX	Apoptosis; Immunology/Inflammation; Neuroscience
	Nitroaspirin (NCX 4016) 是一氧化氮供体和阿司匹林的硝基衍生物，与 Aspirin 结合可抑制环氧合酶=，可作为 COX-1 的直接和不可逆抑制剂。它通过下调 EGFR/PI3K/STAT3 信号传导和调节 Bcl-2 家族蛋白，显着诱导顺铂耐药人卵巢癌细胞的细胞周期停滞和凋亡，具有抗血栓和抗血小板特性。
T68002	Naroparcil	Thrombin	Proteases/Proteasome
	Naroparcil 是一种可口服的硫代苷类化合物，是一种 4-甲基伞形 β-D-木糖苷类似物，在静脉血栓形成（颈静脉）的Wessler淤滞模型中显示出抗血栓形成作用。Naroparcil 增强了凝血酶/肝素辅因子II复合物的形成，诱导了处理兔血浆中硫酸皮肤素样物质的出现，但减少了与（125I）-人α-凝血酶孵育的血浆中的凝血酶/抗凝血酶III复合物的形成。
T2368L	Edoxaban Lixiana,依杜沙班	Factor Xa; Thrombin	Metabolism; Proteases/Proteasome
	Edoxaban (Lixiana) (DU-176) 是一种选择性的，口服有效的 factor Xa (FXa)抑制剂。Edoxaban 对游离 FXa 和凝血酶原的 Ki 分别为 0.561 nM 和 2.98 nM。Edoxaban 是一种抗凝剂，可用于预防中风。Edoxaban 还是一种凝血酶和凝血因子 IXaβ (FIXa) 的弱抑制剂，Ki 值分别为 6.00 μM 和 41.7 μM，对 FXa 的选择性超过 10000 倍。由于具有抗血栓形成的特性，Edoxaban 可用于预防血栓栓塞性疾病的研究。
T29070	Uproleselan
	Uproleselan has antithrombotic and antineoplastic properties.
T70737	HN 11500
	HN 11500 is an antithrombotic agent and thromboxane A2 receptor antagonist.
T17024	Tecarfarin sodium ATI-5923 sodium	Others	Others
	Tecarfarin sodium is a novel orally active non-competitive vitamin K epoxide reductase antagonist. Tecarfarin sodium has the antithrombotic activity.
T12741	Ro-15-2041	Others	Others
	Ro 15-2041 is a selective inhibitor of platelet phosphodiesterase, with antithrombotic properties.
T15256	Etofylline clofibrate	Others	Others
	Etofylline clofibrate has a hypolipidemic and antithrombotic effect and it also has an agonistic interaction with intimal PGI2.
T30186	AT-1459 UNII-JWP323ABVS
	AT-1459 is a novel direct thrombin inhibitor with antithrombotic efficacy.
T17091	Thrombin Inhibitor 2	Others	Others
	Thrombin Inhibitor 2 is a small molecule direct thrombin inhibitor. Thrombin Inhibitor 2 has antithrombotic activity.
T21471	Dazoxiben free base Dazoxiben hydrochloride,Dazoxiben hydrochloride, Dazoxiben HCl,Dazoxiben hydrochloride, UK-37,248-01
	Dazoxiben is an antithrombotic agent used to reduce the formation of blood clots.
T70458	FXIa-6f
	FXIa-6f is a high affinity, orally bioavailable macrocyclic FXIa inhibitor with antithrombotic activity in preclinical species
T68719	Ro 15-2041
	Ro 15-2041 is a selective platelet camp phosphodiesterase inhibitor with antithrombotic properties.
T26874	BN 50341 BN50341,BN-50341
	BN 50341 is an inhibitor of antithrombotic platelet activating factor.
T28909	TA-993 maleate TA 993,TA993,TA-993
	TA-993 is a calcium channel antagonist. TA-993 has an antithrombotic effect.
T70909	AY 31390
	AY 31390 is a phosphodiesterase (PDE) inhibitor with antithrombotic activity.
T70536	Idraparinux Na
	Idraparinux Na is an Antithrombotic, Indirect, Selective, Synthetic Factor Xa Inhibitor
T16377	Odiparcil SB-424323	Thrombin	Proteases/Proteasome
	Odiparcil is an orally active beta-d-thioxyloside analog. Odiparcil is an indirect thrombin inhibitor that exerts its anticoagulant effect through activation of antithrombin II (heparin cofactor II). It also has an antithrombotic activity associated with a reduced risk of adverse bleeding events.
T24898	Trifenagrel BW-325U,BW 325U,BW325U
	Trifenagrel is an antithrombotic. It has been found to produce less gastric irritation and fecal blood loss in humans.
T80512	Thrombin receptor peptide ligand	Thrombin	Proteases/Proteasome
	Thrombin receptor peptide ligand为凝血酶受体的一种拮抗肽，用于抗血栓治疗。
T12694	Razaxaban hydrochloride BMS 561389 hydrochloride,DPC 906 hydrochloride	Others	Others
	Razaxaban hydrochloride is a highly potent, selective and orally active inhibitor of factor Xa(Ki of 0.19 nM),has strongly antithrombotic activity.
T12782	RWJ-445167 3DP-10017	Factor Xa; Thrombin	Metabolism; Proteases/Proteasome
	RWJ-445167 is a thrombin and factor Xa dual inhibitor(Ki of 4.0 nM and 230 nM, respectively), with potent antithrombotic activity.
T29190	YM-75466 YM 466,YM-466,YM75466,YM 75466,YM-75466 Free
	YM-75466 is a factor Xa inhibitor. YM-75466 did not prolong coagulation time even at the dose which exerted significant antithrombotic effects, while it decreased TAT level in plasma in a dose-dependent manner.

化合物

Betrixaban maleate

Cat.No: T4980

Target: Factor Xa

Cat.No: T3536

Target: P2Y Receptor

Cat.No: T4132

Synonym: BMS-646786

Target: P2Y Receptor

Cat.No: T0435

Synonym: (+/-)-Sulfinpyrazone,G-28315,苯磺保泰松,NSC 75925

Target: COX

Dabigatran etexilate

Cat.No: T0389

Synonym: 达比加群酯,BIBR 1048

Target: Thrombin

Cat.No: T4190

Synonym: PCR 5332,Ticlid,噻氯匹定

Target: ATPase, Adiponectin receptor

Cat.No: T31206

Synonym: YM 150,Darexaban, Tanexaban,YM150

Target: Factor Xa

Cat.No: T6182

Synonym: L700462,Aggrastat,替罗非班,MK383

Target: Integrin

Dabigatran Etexilate Mesylate

Cat.No: T5133

Synonym: 甲磺酸达比加群酯,BIBR 1048MS,Dabigatran etexilate methanesulfonate

Target: Thrombin

Tirofiban hydrochloride monohydrate

Cat.No: T2537

Synonym: Tirofiban Hydrochloride,盐酸替罗非班水合物,MK-383 Hydrochloride,盐酸替罗非班

Target: ATPase, Integrin

Clopidogrel hydrogen sulfate

Cat.No: T0182L

Synonym: 硫酸氢氯吡格雷,(S)-(+)-Clopidogrel hydrogen sulfate,(S)-(+)-Clopidogrel bisulfate,SR-25990C,Clopidogrel,硫酸氯吡格雷

Target: P450, P2Y Receptor

Edoxaban Tosylate Monohydrate

Cat.No: T2368

Synonym: DU-176b,DU-176b tosylate Monohydrate,Lixiana,Edoxaban,依度沙班对甲苯磺酸盐一水化合物

Target: Factor Xa, Thrombin

Cat.No: T13210

Synonym: PCA-4230

Target: Others

Cat.No: T67991

Target: Others

Fondaparinux sodium

Cat.No: T4076

Synonym: Natural heparin pentasaccharide Sodium,Fondaparin sodium,磺达肝素(癸)钠,磺达肝癸钠,SR-90107A,Arixtra

Target: Factor Xa

Cat.No: T25741

Synonym: HN 11500,CL-871502

Target: PPAR

Cat.No: T80792

Target: Others

Cat.No: T27920

Synonym: LY-517717,LY517717

Target: Factor Xa

Cat.No: T27318

Synonym: CI-1031,BX-807834,PD-200022,CI1031,BX807834,ZK-807834

Target: Factor Xa

Cat.No: T17025

Synonym: ATI-5000,ATI-5923

Target: Others

Sodium Tetradecyl Sulfate

Cat.No: T9620

Target: Others

Cat.No: T3757

Target: Thrombin, Platelet aggregation

Cat.No: T24542

Synonym: NP 313,NSC 4264,NSC-4264,NSC4264

Cat.No: T3469

Synonym: PCI27483

Target: Others

Cat.No: T8580

Target: Adrenergic Receptor

Cat.No: T11825

Target: PPAR

Cat.No: T63966

Synonym: UDM-003183

Target: Protease-activated Receptor

Cat.No: T16328

Synonym: 2-乙酰氧基苯甲酸-3-硝酸甲基苯酯,NCX 4016

Target: Apoptosis, COX

Cat.No: T68002

Target: Thrombin

Cat.No: T2368L

Synonym: Lixiana,依杜沙班

Target: Factor Xa, Thrombin

Cat.No: T29070

Cat.No: T70737

Tecarfarin sodium

Cat.No: T17024

Synonym: ATI-5923 sodium

Target: Others

Cat.No: T12741

Target: Others

Etofylline clofibrate

Cat.No: T15256

Target: Others

Cat.No: T30186

Synonym: UNII-JWP323ABVS

Thrombin Inhibitor 2

Cat.No: T17091

Target: Others

Dazoxiben free base

Cat.No: T21471

Synonym: Dazoxiben hydrochloride,Dazoxiben hydrochloride, Dazoxiben HCl,Dazoxiben hydrochloride, UK-37,248-01

Cat.No: T70458

Cat.No: T68719

Cat.No: T26874

Synonym: BN50341,BN-50341

Cat.No: T28909

Synonym: TA 993,TA993,TA-993

Cat.No: T70909

Cat.No: T70536

Cat.No: T16377

Synonym: SB-424323

Target: Thrombin

Cat.No: T24898

Synonym: BW-325U,BW 325U,BW325U

Thrombin receptor peptide ligand

Cat.No: T80512

Target: Thrombin

Razaxaban hydrochloride

Cat.No: T12694

Synonym: BMS 561389 hydrochloride,DPC 906 hydrochloride

Target: Others

Cat.No: T12782

Synonym: 3DP-10017

Target: Factor Xa, Thrombin

Cat.No: T29190

Synonym: YM 466,YM-466,YM75466,YM 75466,YM-75466 Free

Cat. No.	Product Name	Target	Signaling Pathways
T13302	Viquidil hydrochloride Quinotoxine hydrochloride	Others	Others
	Viquidil hydrochloride (Quinotoxine hydrochloride) 是奎尼丁的同分异构体，是一种脑血管扩张剂，具有抗血栓作用。
T4853	TRIA-662 3-Carbamoyl-1-methylpyridinium Chloride,3-氨基甲酰-1-甲基氯化吡啶,1-Methylnicotinamide chloride,1-methylpyridin-1-ium-3-carboxamide hydrochloride,Nicotinamide Chloromethylate	Others; Endogenous Metabolite	Metabolism; Others
	TRIA-662 (Nicotinamide Chloromethylate) 是内源性代谢产物的一种。
T3817	Darutigenol	Others	Others
	Darutigenol 是一种戊二萜，从Siegesbecikia orientalis L.中分离得到。
T2S0504	Ilexoside D	Others	Others
	Ilexoside D has ant-allergic, and anti-coagulant activities, it shows anti-tissue factor activity as well as the antithrombotic activity.
T8121	Octacosanoic acid	Anti-infection	Microbiology/Virology
	Octacosanoic acid 具有抗血小板和抗血栓作用。
T5725	Salvianolic acid B 丹酚酸B,lithospermic acid B,Dan Shen Suan B	Sirtuin; Autophagy	Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Salvianolic acid B (Dan Shen Suan B) 是一种来自丹参提取物的水溶性抗氧化剂，具有抗血小板聚集、抗凝和抗血栓作用。它常用来研究微循环疾病。
T8061	Citronellal (±)-Citronellal,香茅醛	Others	Others
	Citronellal ((±)-Citronellal) 是多种芳香植物精油的单萜烯，具有促进睡眠、安定和抗伤害的作用。它可以降低机械伤害感受，且部分通过 NO-cGMP-ATP 敏感型 K⁺渠道通道介导的。
T2727	Salvianolic acid B	Others	Others
	Salvianolic acid B (Dan Shen Suan B) 是一种来自丹参提取物的水溶性抗氧化剂，具有抗血小板聚集、抗凝和抗血栓作用。它常用来研究微循环疾病。
TN1996	Nothofagin	ERK; IL Receptor; TNF	Apoptosis; Immunology/Inflammation; MAPK
	Nothofagin 具有抗氧化和抗血栓活性，它通过抑制高渗透性、CAMs 的表达以及白细胞的粘附和迁移具有抗炎活性，从而支持其作为血管炎症性疾病的治疗作用。
T4S0498	Glaucocalyxin A 蓝萼甲素,Wangzaozin B,Leukamenin F	Apoptosis; Akt; Caspase; PI3K	Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Glaucocalyxin A (Leukamenin F) 是来自日本黑纹病菌的一种对映型月桂基二萜，具有抗肿瘤作用。它通过调节PI3K/Akt 信号通路抑制 GLI1 的核易位，诱导骨肉瘤凋亡。
TN2002	Obovatol	BCL; Caspase; JAK	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Proteases/Proteasome; Stem Cells
	Obovatol has antioxidant, neuroprotective, antiinflammatory, antithrombotic and antitumour effects, it is a potent NF-κB inhibitors for Alzheimer's disease treatment.

天然产物

Viquidil hydrochloride

Cat.No: T13302

Synonym: Quinotoxine hydrochloride

Target: Others

Cat.No: T4853

Synonym: 3-Carbamoyl-1-methylpyridinium Chloride,3-氨基甲酰-1-甲基氯化吡啶,1-Methylnicotinamide chloride,1-methylpyridin-1-ium-3-carboxamide hydrochloride,Nicotinamide Chloromethylate

Target: Others, Endogenous Metabolite

Cat.No: T3817

Target: Others

Cat.No: T2S0504

Target: Others

Octacosanoic acid

Cat.No: T8121

Target: Anti-infection

Salvianolic acid B

Cat.No: T5725

Synonym: 丹酚酸B,lithospermic acid B,Dan Shen Suan B

Target: Sirtuin, Autophagy

Cat.No: T8061

Synonym: (±)-Citronellal,香茅醛

Target: Others

Salvianolic acid B

Cat.No: T2727

Target: Others

Cat.No: TN1996

Target: ERK, IL Receptor, TNF

Glaucocalyxin A

Cat.No: T4S0498

Synonym: 蓝萼甲素,Wangzaozin B,Leukamenin F

Target: Apoptosis, Akt, Caspase, PI3K

Cat.No: TN2002

Target: BCL, Caspase, JAK

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