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Search Results for " tricyclic "

73

抑制剂 & 化合物

12

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T6065	Triciribine VD-0002,Tricyclic nucleoside,NSC 154020,曲西立滨,API-2,TCN	Akt; HIV Protease; DNA/RNA Synthesis	Cell Cycle/Checkpoint; Cytoskeletal Signaling; DNA Damage/DNA Repair; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Triciribine (NSC-154020) 是一种 DNA 合成抑制剂，也抑制 Akt 和 HIV-1/2，IC50分别为 130 nM 和 0.02-0.46 μM。
T83937	Tricyclic cytosine tC
	Tricyclic cytosine tC 是一种用于在活细胞中成像 RNA 的荧光胞嘧啶类似物。当与共聚焦成像技术结合使用时，可用于研究单细胞分辨率下的 RNA 合成、降解和运输。激发/发射最大值 (λ) = 375/505 nm；消光系数 = 4000 M-1cm-1；量子产率 = 0.2。
T4274	Melitracen hydrochloride 盐酸美利曲辛,盐酸美力他欣,Thymeol hydrochloride,Melixeran	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Melitracen hydrochloride (Thymeol hydrochloride) 是一种可口服的双相抗抑郁药和抗焦虑药。它可以通过突触前膜抑制去甲肾上腺素和5-羟色胺(5-HT)的吸收，从而诱导突触空间中单胺递质的增加。
T3086	Mesoridazine Besylate Mesoridazine benzenesulfonate,Serentil,苯磺酸美索达嗪	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Mesoridazine Besylate (Serentil) 是一种哌啶类精神安定药，属于称为吩噻嗪类的药物，用于治疗精神分裂症。它是硫利达嗪的代谢物。
T1327	Nortriptyline hydrochloride Desitriptyline HCl,EN-7048 hydrochloride,盐酸去甲替林,Desmethylamitriptyline hydrochloride,ELF-101 hydrochloride,去甲替林	Apoptosis; Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; AChR; Norepinephrine; Autophagy; Histamine Receptor; Drug Metabolite	Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience
	Nortriptyline hydrochloride (ELF-101 hydrochloride) 是一种三环类抗抑郁药，用于缓解抑郁症的症状。它是 Amitriptyline 的主要活性代谢产物，是有效自噬抑制剂。
T20025	Imipramine Melipramine,HSDB3100,HSDB 3100,Dimipressin,HSDB-3100
	Imipramine is an agent of tricyclic antidepressants.
T37015	Iprindole	5-HT Receptor	GPCR/G Protein; Neuroscience
	Iprindole, a tricyclic indole antidepressant, is a dual weak inhibitor of noradrenaline and 5-HT uptake [1].
T0943	Carbamazepine 卡马西平,NSC 169864	Mitophagy; Sodium Channel; Autophagy	Autophagy; Membrane transporter/Ion channel
	Carbamazepine (NSC-169864) 是与三环抗抑郁药化学相关的三环化合物，具有抗惊厥和镇痛特性。它通过减少多突触反应和阻断强直后增强发挥其抗惊厥活性。它通常用于治疗与三叉神经痛相关的疼痛。
T0172	Maprotiline hydrochloride Maprotiline HCl,盐酸马普替林,Psymion,Deprilept,Ludiomil	5-HT Receptor; Adrenergic Receptor; AChR; Norepinephrine; Autophagy; Histamine Receptor	Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Maprotiline hydrochloride (Psymion) 是一种桥环四环类抗抑郁药，是去甲肾上腺素重吸收抑制剂。
T0204	Protriptyline hydrochloride 盐酸普罗替林,Protriptyline HCl	5-HT Receptor; AChE	GPCR/G Protein; Neuroscience
	Protriptyline hydrochloride (Protriptyline HCl) 是一种含有一个仲胺的三环结构抗抑郁试剂，可以用于抑郁和 ADHD 的相关研究。它使动物精力充沛起激励作用，并且有时用于嗜睡症的相关研究。
T12232	Nitroxazepine CIBA 2330Go	Serotonin Transporter	Neuroscience
	Nitroxazepine (CIBA 2330Go) 是三环抗抑郁化合物，是一种 5-羟色胺去甲肾上腺素再摄取抑制剂，可用于抗抑郁的研究。
T7941	Imipramine hydrochloride 盐酸丙咪嗪,Imipramine (hydrochloride),Tofranil,G 22355,Imipramine HCl,Melipramine	Serotonin Transporter	Neuroscience
	Imipramine hydrochloride (Imipramine HCl) 可抑制血清素转运蛋白，IC50=32 nM。它可阻止胰酶的易位，阻碍 MV 和外泌体的分泌。
T21013	Clomipramine Chlorimipramine,Anafranil,Clomicalm,Anafranil (free base),Clomipramina,氯米帕明	5-HT Receptor	GPCR/G Protein; Neuroscience
	Clomipramine (Clomicalm) 是一种三环类抗抑郁药，能够有效阻断 5-HT 再摄取 (IC50:1.5 nM) ，可用于研究强迫症 (OCD) 及抑郁症。
T1540	Doxepin hydrochloride Toruan,Doxepin HCl,Aponal,Novoxapin,盐酸多塞平	P450; Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; AChR; Norepinephrine; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience
	Doxepin hydrochloride (Aponal) 是一种可口服的三环抗抑郁剂，是选择性组胺受体 H1拮抗剂。它也是 CYP450抑制剂，抑制 CYP450 2C19和 CYP450 1A2。
T0678	Amitriptyline hydrochloride Amitriptyline HCl,Tryptizol,盐酸阿米替林,Domical,Annoyltin	Trk receptor; Sigma receptor; 5-HT Receptor; Serotonin Transporter; Sodium Channel; Adrenergic Receptor; AChR; Norepinephrine; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; Tyrosine Kinase/Adaptors
	Amitriptyline hydrochloride (Annoyltin) 是血清素再摄取转运体和去甲肾上腺素再摄取转运体抑制剂，还与多巴胺再摄取转运体结合，其Ki 为 2.58 μM。它也抑制肾上腺素能受体、毒蕈碱受体、组胺受体、5-羟色胺受体。它是TrkA 和TrkA 受体的激动剂，具有强神经营养活性和有抗抑郁作用。
T60330	Metapramine
	Metapramine (19560 RP) 是一种三环类抗抑郁剂。Metapramine 抑制去甲肾上腺素 (norepinephrine) 的再摄取，而不影响血清素或多巴胺的再摄取。Metapramine 是 N-methyl-D-aspartic acid (NMDA) 受体复合物通道的低亲和力拮抗剂。
T0255	Clomipramine hydrochloride Clomipramine HCl,Anafranil,盐酸氯米帕明	Dopamine Receptor; 5-HT Receptor; Serotonin Transporter; Norepinephrine; GST	GPCR/G Protein; Neuroscience; oxidation-reduction
	Clomipramine hydrochloride (Anafranil) 是一种5-羟色胺转运体(Ki:0.14 nM)、去甲肾上腺素转运体(Ki:54 nM)和多巴胺转运体(Ki:3 nM)阻断剂。
T0991	Desipramine hydrochloride NSC-114901,Desmethylimipramine,盐酸去甲咪嗪,JB-8181,EX-4355,Norimipramine,G-35020	Dopamine Receptor; 5-HT Receptor; Serotonin Transporter; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Desipramine hydrochloride (Norimipramine) 是一种二苯并氮杂类衍生物三环类抗抑郁药，可作为选择性去甲肾上腺素再摄取抑制剂。它还显示出较弱的 5-羟色胺再摄取抑制、α1 阻断、抗组胺和抗胆碱能作用。
T0074L	Chlorprothixene hydrochloride NSC 78193,Minithixen,泰尔登盐酸盐,Truxal hydrochloride,盐酸氯普噻吨,NSC 56379,NSC 169899,Minithixen hydrochloride	Dopamine Receptor; 5-HT Receptor; Antibacterial; AChR; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Chlorprothixene hydrochloride (Truxal hydrochloride) 是一种多巴胺和组胺受体拮抗剂，具有抗精神病作用，高亲和力地结合人 D1，D2，D3，D5，H1 受体，Ki 分别为 18 nM，2.96 nM，4.56 nM，9 nM 和 3.75 nM。
T15773	Lofepramine Gamanil,洛非帕明,Amplit,Leo 640,Lopramine	5-HT Receptor; Norepinephrine	GPCR/G Protein; Neuroscience
	Lofepramine (Leo 640) 是一种有效的三环抗抑郁药，广泛地代谢为 Desipramine。它能够抑制摄取促进去甲肾上腺素能神经传递，以及抑制神经元摄取 5-羟色胺和色氨酸吡咯酶，增强 5-羟色胺能神经传递，进而发挥其抗抑郁作用。它还具有显著的抗焦虑效果。
T1568	Amoxapine 阿莫沙平,CL-67772	GlyT	Neuroscience
	Amoxapine (CL-67772) 是一种dibenzoxazepine 家族的四环抗抑郁药，常被归类为仲胺三环类抗抑郁药。
T68070	Fezolamine	Norepinephrine	Neuroscience
	Fezolamine 是一种新型可口服的非三环类化合物，具有抗抑郁活性。它在体外阻断[3H]去甲肾上腺素的突触体摄取方面的选择性是摄取[4H]3-羟色胺或[3H]多巴胺的3至2倍。在使用单胺耗尽动物的经典行为测试中，它阻止了利血平和四苯的抑制作用。
T34214	QA 241 QA-241,QA241
	QA 241 is a tricyclic quinolone.
T28557	Ro 14-9578 Ro-14-9578,Ro 149578
	Ro 14-9578 is anantibacterial agent in the class of tricyclic quinolone.
T71643	FG-7080
	FG-7080 is a non-tricyclic serotonin reuptake inhibitor.
T25248	Cianopramine Ro 112465,Ro-112465,Ro112465
	Cianopramine is a tricyclic antidepressant and a potent neuronal serotonin (5-HT) uptake inhibitor in animals.
T33675	Nimbosone
	Nimbosone is a novel tricyclic diterpenoid.
T25047	Alfetamine alpha-allyl-phenethylamine
	Alfetamine is a chemical compound of the phenethylamine family. It is similar to imipramine and amitriptyline, two tricyclic antidepressants.
T23628	AD-2646 AD2646
	AD-2646 is a new quinoline derivative. It also has similar pharmacological properties to tricyclic antidepressants.
TNU0289	1,N6-Ethenoadenosine
	Nucleoside Derivatives - Tricyclic nucleosides
T32805	LK 157 LK-157,LK157
	LK 157 is a tricyclic carbapenem with potent activity against class A and class C beta-lactamases.
T13377	(Z)-10-Hydroxynortriptyline (Z)-10-Hydroxy Nortriptyline	IL Receptor	Immunology/Inflammation
	(Z)-10-Hydroxy Nortriptyline is a Nortriptyline metabolite, and is a tricyclic antidepressant,and is used to relieve the symptoms of depression.
T12202	Nec-4	TNF	Apoptosis
	Nec-4 is a potent inhibitor of receptor interacting protein 1 (RIP1)(IC50 of 2.6 μM),and is a tricyclic derivative.
T37307	Nordoxepin hydrochloride
	Doxepin is a tricyclic antidepressant. Desmethyldoxepin is the primary metabolite of doxepin, produced by metabolism at the liver. The metabolism of tricyclic antidepressants, including doxepin, is affected by a variety of factors, including age, genetics, and drug-drug interactions.
T15132L	Dimetacrine tartrate Linostil,Istonil,Istonyl,Miroistonil,MO 709
	Dimetacrine tartrate is a tricyclic antidepressant (TCA) used for the therapy of depression in Europe and formerly in Japan.
T82804	Butriptyline Butriptylene
	Butriptyline (Butriptylene)，三环抗抑郁剂，具有口服生物活性。
T20017	Melitracen Melitracene
	Melitracen is a tricyclic antidepressant.
T69620	Demexiptiline
	Demexiptiline is a tricyclic antidepressant used in France for the treatment of depression. It acts primarily as a norepinephrine reuptake inhibitor similarly to desipramine.
T69265	Pirandamine Free Base
	Pirandamine Free Base is a tricyclic derivative which acts as a selective serotonin reuptake inhibitor
T13338	WEHI-9625	BCL	Apoptosis
	WEHI-9625 is a tricyclic sulfone small molecule apoptosis inhibitor (EC50: 69 nM).
T69579	Dothiepin HCl
	Dothiepin HCl is a Tricyclic antidepressant (TCA), acting as a serotonin–norepinephrine reuptake inhibitor (SNRI) and also having other activities including antihistamine, antiadrenergic, antiserotonergic, anticholinergic, and sodium channel-blocking effects.
T71355	MDL-27788
	MDL-27788 is a tricyclic inhibitor.
T74205	Imipramine N-oxide
	Imipramine N-oxide 是 Imipramine 的代谢物。Imipramine 是一种叔胺三环类抗抑郁药。
TNU1296	6-(β-D-5-O-(4,4’-Dimethoxytrityl)-2-deoxyribofuranosyl)-3,4-dihydro-8H-pyrimido[4,5-c][1,2]oxazin-7-one
	Nucleoside Derivatives - Bi-/Tricyclic nucleosides; Protected nucleosides w/NH2/OH open
T68327	Dexnafenodone Free Base
	Dexnafenodone Free Base is a potent inhibitor of noradrenaline, and to a lesser degree of serotonin reuptake, induced changes in the pattern of sleep which are comparable to those of non‐sedating tricyclic antidepressants.
T17101	Tiopinac 硫平酸,RS 40974	Others	Others
	Tiopinac 是一种三环化合物，对动物具有高效的抗炎、镇痛和解热作用，能够抑制前列腺素合成，对人类具有适度的抗血小板聚集特性。
T74838	MTHFD2-IN-4 sodium
	MTHFD2-IN-4 sodium, 一种三环香豆素衍生物，有效抑制MTHFD2，应用于癌症研究。
T36119	3-hydroxy Desloratidine
	3-hydroxy Desloratidine is a major metabolite of desloratadine , a tricyclic antagonist of the histamine H1 receptor.
T71773	Levomepromazine Maleate
	Levomepromazine Maleate is a Tricyclic antidepressant (TCA), acting as a serotonin–norepinephrine reuptake inhibitor (SNRI) and also having other activities including antihistamine, antiadrenergic, antiserotonergic, anticholinergic, and sodium channel-blocking effects.
TNU0291	1,N6-Etheno-9-(b-D-xylofuranosyl)adenosine
	Nucleoside Derivatives - Tricyclic nucleosides; Xylo-nucleosides

化合物

Cat.No: T6065

Synonym: VD-0002,Tricyclic nucleoside,NSC 154020,曲西立滨,API-2,TCN

Target: Akt, HIV Protease, DNA/RNA Synthesis

Tricyclic cytosine tC

Cat.No: T83937

Melitracen hydrochloride

Cat.No: T4274

Synonym: 盐酸美利曲辛,盐酸美力他欣,Thymeol hydrochloride,Melixeran

Target: Dopamine Receptor, 5-HT Receptor

Mesoridazine Besylate

Cat.No: T3086

Synonym: Mesoridazine benzenesulfonate,Serentil,苯磺酸美索达嗪

Target: Dopamine Receptor, 5-HT Receptor

Nortriptyline hydrochloride

Cat.No: T1327

Synonym: Desitriptyline HCl,EN-7048 hydrochloride,盐酸去甲替林,Desmethylamitriptyline hydrochloride,ELF-101 hydrochloride,去甲替林

Target: Apoptosis, Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, AChR, Norepinephrine, Autophagy, Histamine Receptor, Drug Metabolite

Cat.No: T20025

Synonym: Melipramine,HSDB3100,HSDB 3100,Dimipressin,HSDB-3100

Cat.No: T37015

Target: 5-HT Receptor

Cat.No: T0943

Synonym: 卡马西平,NSC 169864

Target: Mitophagy, Sodium Channel, Autophagy

Maprotiline hydrochloride

Cat.No: T0172

Synonym: Maprotiline HCl,盐酸马普替林,Psymion,Deprilept,Ludiomil

Target: 5-HT Receptor, Adrenergic Receptor, AChR, Norepinephrine, Autophagy, Histamine Receptor

Protriptyline hydrochloride

Cat.No: T0204

Synonym: 盐酸普罗替林,Protriptyline HCl

Target: 5-HT Receptor, AChE

Cat.No: T12232

Synonym: CIBA 2330Go

Target: Serotonin Transporter

Imipramine hydrochloride

Cat.No: T7941

Synonym: 盐酸丙咪嗪,Imipramine (hydrochloride),Tofranil,G 22355,Imipramine HCl,Melipramine

Target: Serotonin Transporter

Cat.No: T21013

Synonym: Chlorimipramine,Anafranil,Clomicalm,Anafranil (free base),Clomipramina,氯米帕明

Target: 5-HT Receptor

Doxepin hydrochloride

Cat.No: T1540

Synonym: Toruan,Doxepin HCl,Aponal,Novoxapin,盐酸多塞平

Target: P450, Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, AChR, Norepinephrine, Histamine Receptor

Amitriptyline hydrochloride

Cat.No: T0678

Synonym: Amitriptyline HCl,Tryptizol,盐酸阿米替林,Domical,Annoyltin

Target: Trk receptor, Sigma receptor, 5-HT Receptor, Serotonin Transporter, Sodium Channel, Adrenergic Receptor, AChR, Norepinephrine, Histamine Receptor

Cat.No: T60330

Clomipramine hydrochloride

Cat.No: T0255

Synonym: Clomipramine HCl,Anafranil,盐酸氯米帕明

Target: Dopamine Receptor, 5-HT Receptor, Serotonin Transporter, Norepinephrine, GST

Desipramine hydrochloride

Cat.No: T0991

Synonym: NSC-114901,Desmethylimipramine,盐酸去甲咪嗪,JB-8181,EX-4355,Norimipramine,G-35020

Target: Dopamine Receptor, 5-HT Receptor, Serotonin Transporter, Adrenergic Receptor

Chlorprothixene hydrochloride

Cat.No: T0074L

Synonym: NSC 78193,Minithixen,泰尔登盐酸盐,Truxal hydrochloride,盐酸氯普噻吨,NSC 56379,NSC 169899,Minithixen hydrochloride

Target: Dopamine Receptor, 5-HT Receptor, Antibacterial, AChR, Histamine Receptor

Cat.No: T15773

Synonym: Gamanil,洛非帕明,Amplit,Leo 640,Lopramine

Target: 5-HT Receptor, Norepinephrine

Cat.No: T1568

Synonym: 阿莫沙平,CL-67772

Target: GlyT

Cat.No: T68070

Target: Norepinephrine

Cat.No: T34214

Synonym: QA-241,QA241

Cat.No: T28557

Synonym: Ro-14-9578,Ro 149578

Cat.No: T71643

Cat.No: T25248

Synonym: Ro 112465,Ro-112465,Ro112465

Cat.No: T33675

Cat.No: T25047

Synonym: alpha-allyl-phenethylamine

Cat.No: T23628

Synonym: AD2646

1,N6-Ethenoadenosine

Cat.No: TNU0289

Cat.No: T32805

Synonym: LK-157,LK157

(Z)-10-Hydroxynortriptyline

Cat.No: T13377

Synonym: (Z)-10-Hydroxy Nortriptyline

Target: IL Receptor

Cat.No: T12202

Target: TNF

Nordoxepin hydrochloride

Cat.No: T37307

Dimetacrine tartrate

Cat.No: T15132L

Synonym: Linostil,Istonil,Istonyl,Miroistonil,MO 709

Cat.No: T82804

Synonym: Butriptylene

Cat.No: T20017

Synonym: Melitracene

Cat.No: T69620

Pirandamine Free Base

Cat.No: T69265

Cat.No: T13338

Target: BCL

Cat.No: T69579

Cat.No: T71355

Imipramine N-oxide

Cat.No: T74205

6-(β-D-5-O-(4,4’-Dimethoxytrityl)-2-deoxyribofuranosyl)-3,4-dihydro-8H-pyrimido[4,5-c][1,2]oxazin-7-one

Cat.No: TNU1296

Dexnafenodone Free Base

Cat.No: T68327

Cat.No: T17101

Synonym: 硫平酸,RS 40974

Target: Others

MTHFD2-IN-4 sodium

Cat.No: T74838

3-hydroxy Desloratidine

Cat.No: T36119

Levomepromazine Maleate

Cat.No: T71773

1,N6-Etheno-9-(b-D-xylofuranosyl)adenosine

Cat.No: TNU0291

Cat. No.	Product Name	Target	Signaling Pathways
T11685	Isolongifolene 异长叶烯,(-)-Isolongifolene	Apoptosis; Others	Apoptosis; Others
	Isolongifolene ((-)-Isolongifolene) 是一种从调料九里香中分离的三环倍半萜烯，具有抗氧化，抗炎，抗癌和神经保护的特性。它通过调节 PI3K/AKT/GSK-3β 信号通路来减轻鱼藤酮诱导的氧化应激，线粒体功能障碍和细胞凋亡。
T0832	Vancomycin hydrochloride 盐酸万古霉素,Vancomycin HCl	Cell wall; Antibacterial; Antibiotic; Autophagy	Autophagy; Immunology/Inflammation; Microbiology/Virology
	Vancomycin hydrochloride (Vancomycin HCl) 是Vancomycin 的盐酸盐，是一种支链三环糖基化肽，对大多数生物体具有杀菌活性，对肠球菌具有抑菌作用。
T1045	Trimipramine maleate Surmontil maleate,马来酸三甲丙咪嗪,三甲丙咪嗪马来酸盐	Dopamine Receptor; 5-HT Receptor; Antibacterial; Adrenergic Receptor; Norepinephrine; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Trimipramine maleate (Surmontil maleate) 是一种 5-HT 受体拮抗剂，对 5-HT1C、5-HT2和 5-HT1A 受体的 pKi 值分别为 6.39、8.10和 4.66。
T2179	Triptolide PG490,NSC 163062,雷公藤甲素	Apoptosis; Mdm2; HSP; NF-κB	Apoptosis; Cytoskeletal Signaling; Metabolism; NF-κB
	Triptolide (PG490) 属于三环二萜类天然产物，是一种 NF-κB 活化的抑制剂。Triptolide 具有免疫抑制、抗风湿、抗炎、抗增殖和抗肿瘤活性。
T0185	Escitalopram Seroplex,依他普仑,S-(+)-Citalopram,艾司西酞普兰,(S)-Citalopram	Dopamine Receptor; 5-HT Receptor; Serotonin Transporter; Adrenergic Receptor; AChR; Norepinephrine; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Escitalopram (Seroplex) 是一种外消旋 Citalopram 的 S-对映体，是一种选择性 5-羟色胺再摄取抑制剂，Ki=0.89 nM，比 R(-)-enantiomer 结合亲和力高 30 倍。它对多巴胺转运体和去甲肾上腺素转运体均有选择性，是一种研究抑郁症的抗抑郁药。
T5693	Pyrroloquinoline quinone disodium salt 吡咯喹啉醌二钠盐,Methoxatin disodium salt	Others; Endogenous Metabolite	Metabolism; Others
	Pyrroloquinoline quinone disodium salt (Methoxatin disodium salt) 一种阴离子型氧化还原循环原醌，作为氧化还原辅助因子。它是从嗜甲基细菌的培养物中分离的，也存在于哺乳动物的组织。它是哺乳动物的必需营养素，对免疫功能很重要。
T80688	β-Patchoulene
	β-Patchoulene, 一种三环倍半萜类化合物，源自广藿香油，主要应用于炎症性疾病治疗。
T11834	Leelamine hydrochloride	Others	Others
	Leelamine hydrochloride, a tricyclic diterpene extracted from pine tree bark, inhibits the transcriptional activity of the androgen receptor, known to regulate fatty acid synthesis [2,3]. This compound acts as a cannabinoid receptor type 1 (CB1) agonist and suppresses SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells, irrespective of androgen receptor status.
T40859	5-Hydroxy-8-methoxypsoralen 5-Hydroxyxanthotoxin,5-Hydroxy-8-methoxypsoralen
	5-Hydroxy-8-methoxypsoralen (5-Hydroxyxanthotoxin) is a metabolite derived from Xanthotoxin, which acts as a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450). It is employed as an agent for the treatment of psoriasis, eczema, vitiligo, and certain cutaneous Lymphomas, in combination with phototherapy involving exposure to sunlight.
T73844	Nortriptyline
	Nortriptyline (Desmethylamitriptyline) 是三环类抗抑郁药，是 Amitriptyline 的主要活性代谢产物，用于缓解抑郁症症状。Nortriptyline 是有效自噬 (autophagy) 抑制剂。
T81095	Stenophyllol B
	Stenophyllol B (compound 4) 是一种具有双环及桥联三环骨架的三聚芪类化合物。该化合物最初在龙脑香科植物中被鉴定，随后在Hopea、Neobalanocarpus、Shorea、Stemonoporus以及Vateri等属的多种物种中发现。
T35770	Cylindrospermopsin
	Cylindrospermopsin, a tricyclic uracil derivative, is a cyanobacterial toxin that was first discovered in an algal bloom contaminating a local drinking supply on Palm Island in Queensland, Australia after an outbreak of a mysterious disease. Cylindrospermopsin targets protein and glutathione synthesis in hepatocytes (IC50s = 1.3 and 2.4 &#181M, respectively), leading to cell death. [1] It has been shown to inhibit the activity of the uridine monophosphate synthase complex with a Ki value of 10 &...

天然产物

Cat.No: T11685

Synonym: 异长叶烯,(-)-Isolongifolene

Target: Apoptosis, Others

Vancomycin hydrochloride

Cat.No: T0832

Synonym: 盐酸万古霉素,Vancomycin HCl

Target: Cell wall, Antibacterial, Antibiotic, Autophagy

Trimipramine maleate

Cat.No: T1045

Synonym: Surmontil maleate,马来酸三甲丙咪嗪,三甲丙咪嗪马来酸盐

Target: Dopamine Receptor, 5-HT Receptor, Antibacterial, Adrenergic Receptor, Norepinephrine, Histamine Receptor

Cat.No: T2179

Synonym: PG490,NSC 163062,雷公藤甲素

Target: Apoptosis, Mdm2, HSP, NF-κB

Cat.No: T0185

Synonym: Seroplex,依他普仑,S-(+)-Citalopram,艾司西酞普兰,(S)-Citalopram

Target: Dopamine Receptor, 5-HT Receptor, Serotonin Transporter, Adrenergic Receptor, AChR, Norepinephrine, Histamine Receptor

Pyrroloquinoline quinone disodium salt

Cat.No: T5693

Synonym: 吡咯喹啉醌二钠盐,Methoxatin disodium salt

Target: Others, Endogenous Metabolite

Cat.No: T80688

Leelamine hydrochloride

Cat.No: T11834

Target: Others

5-Hydroxy-8-methoxypsoralen

Cat.No: T40859

Synonym: 5-Hydroxyxanthotoxin,5-Hydroxy-8-methoxypsoralen

Cat.No: T73844

Cat.No: T81095

Cylindrospermopsin

Cat.No: T35770

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