89
31
1
55
Cat. No. | Product Name | ||
---|---|---|---|
L7700 | 神经再生化合物库 | 524 compounds | |
524 种神经再生相关化合物的独特集合,可用于高通量筛选和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12218 |
NFAT Transcription Factor Regulator-1
|
IL Receptor | Immunology/Inflammation |
NFAT Transcription Factor Regulator-1 是 IL-2 合成 的抑制剂,IC50 值为182 nM。 | |||
TP1761L |
Handle region peptide, rat acetate
Handle region peptide, rat acetate(749227-53-0 free base) |
Others | Others |
Handle region peptide, rat acetate(749227-53-0 free base) 是一种肾素原受体拮抗剂,可抑制糖尿病肾病的进展并具有抗炎作用。 | |||
T1792L |
Regorafenib monohydrate
|
Raf; VEGFR; c-RET; PDGFR; c-Kit; Autophagy | Angiogenesis; Apoptosis; Autophagy; MAPK; Tyrosine Kinase/Adaptors |
Regorafenib monohydrate 是一种新型口服多激酶抑制剂,对VEGFR1/2/3、PDGFRβ、Kit、RET 和Raf-1的IC50分别为 13、4.2、46、22、7、1.5 和 2.5 nM。 | |||
T1792 |
Regorafenib
BAY 73-4506,瑞戈非尼,Fluoro-Sorafenib,瑞格非尼 |
Raf; VEGFR; c-RET; PDGFR; c-Kit; Autophagy | Angiogenesis; Apoptosis; Autophagy; MAPK; Tyrosine Kinase/Adaptors |
Regorafenib (BAY 73-4506) 是一种多靶点受体酪氨酸激酶抑制剂,抑制 RET、C-RAF、VEGFR2、c-Kit、VEGFR1 和 PDGFRβ (IC50=1.5/2.5/4.2/7/13/22 nM),具有口服活性。Regorafenib 具有抗肿瘤和抗血管生成活性。 | |||
T11339 |
Furegrelate sodium
U-63557A |
PPAR | DNA Damage/DNA Repair; Metabolism |
Furegrelate sodium (U-63557A) 是口服有效的、血栓素合酶选择性抑制剂,抑制人血小板微粒体血栓素 A2 (TxA2) 合酶的 IC50为 15 nM。它正在开发作为抗血小板药物。 | |||
T1831 |
StemRegenin 1
SR1 |
AhR; Aryl Hydrocarbon Receptor | Immunology/Inflammation; Metabolism |
StemRegenin 1 (SR1) 是一种芳香烃受体拮抗剂,IC50为 127 nM。 | |||
T8402 |
Regorafenib Hydrochloride
瑞戈非尼盐酸盐,BAY73-4506 hydrochloride |
Raf; VEGFR; c-RET; PDGFR; Autophagy | Angiogenesis; Apoptosis; Autophagy; MAPK; Tyrosine Kinase/Adaptors |
Regorafenib Hydrochloride (BAY73-4506 hydrochloride) 是一种新型口服多激酶抑制剂,可抑制血管生成、基质和致癌受体酪氨酸激酶,具有强大的临床前抗肿瘤活性。它靶向作用于 VEGFR1/2/3、PDGFRβ、Kit、RET 和 Raf-1,IC50值分别为 13/4.2/46、22、7、1.5 和 2.5 nM。 | |||
T21818 |
Pregnenolone Carbonitrile
Pregnenolone 16α-carbonitrile ,5-Pregnen-3β-ol-20-one-16α-carbonitrile |
P450 | Metabolism |
Pregnenolone Carbonitrile (5-Pregnen-3β-ol-20-one-16α-carbonitrile) 是一种啮齿动物-PXR 的激活剂,可诱导 CYP3A 的表达。 | |||
T34383L |
2H-Naphth[2′,1′:4,5]indeno[1,2-d][1,3]dioxole, pregn-4-ene-3,20-dione deriv
|
Others | Others |
2H-Naphth[2′,1′:4,5]indeno[1,2-d][1,3]dioxole, pregn-4-ene-3,20-dione deriv在Sprague Dawley大鼠上进行测试时显示出高局部抗炎效力和高肺选择性。 | |||
T3223 |
16beta-Methyl-16alpha,17alpha-epoxypregnenolone
|
Others | Others |
16beta-Methyl-16alpha,17alpha-epoxypregnenolone 用作药物中间体。 | |||
T60000 |
STING (WT/R232) activity regulator 126
|
STING | Immunology/Inflammation |
STING (WT/R232) activity regulator 126 是一种具有抗菌和抗病毒作用的 STING 调节剂。 | |||
T62899 |
Tau-aggregation and neuroinflammation-IN-1
|
Microtubule Associated; NO Synthase | Cytoskeletal Signaling; Immunology/Inflammation |
Tau-aggregation and neuroinflammation-IN-1 是一种有效的 Tau 蛋白聚集体抑制剂, 对 AcPHF6 和全长 tau 蛋白聚集体显示出显著的抑制活性。Tau-aggregation and neuroinflammation-IN-1具有抗炎活性且可减少 NO 释放。Tau-aggregation and neuroinflammation-IN-1 对 LSP 刺激的 BV2 细胞具有低细胞毒性。Tau-aggregation and neuroinflammation-IN-1 可逆转冈田酸诱导的大鼠记忆障碍。 | |||
T34280 |
Regrelor disodium
INS-50589,INS50589,Regrelor sodium,Regrelor,INS 50589 |
P2Y Receptor | GPCR/G Protein; Neuroscience |
Regrelor disodium (INS 50589) 是一种 p2y12 受体拮抗剂,可预防血栓形成,可有效抑制血管平滑肌细胞收缩,抑制细胞增殖,减少炎症。 | |||
T11339L |
Furegrelate
|
PPAR | DNA Damage/DNA Repair; Metabolism |
FUREGRELATE 是一种血栓素 A2 (TxA2) 合酶抑制剂,可减缓新生仔猪肺动脉高压的发展。 | |||
T3222 |
16,17-Epoxypregnenol
16alpha,17alpha-Epoxypregnenolone,16,17-环氧孕烯醇酮 |
Others | Others |
16,17-Epoxypregnenol 用作药物中间体。 | |||
T3219 |
16,17-Epoxypregnenolone acetate
16alpha,17alpha-Epoxypregnenolone acetate,16,17-环氧孕烯醇酮醋酸酯 |
Others | Others |
16,17-Epoxypregnenolone acetate (16alpha,17alpha-Epoxypregnenolone acetate) 可由洋葱伯克霍尔德菌 SE-1 生产。 | |||
T3225 |
16,17-Epoxy-21-acetoxypregnenolone
|
Others | Others |
16,17-Epoxy-21-acetoxypregnenolone 用作药物中间体。 | |||
T10157 |
Regorafénib N-oxyde (M2)
瑞戈非尼杂质 13 |
Raf; VEGFR; c-RET; PDGFR; c-Kit; Drug Metabolite | Angiogenesis; Apoptosis; MAPK; Metabolism; Tyrosine Kinase/Adaptors |
Regorafénib N-oxyde M2 是 Regorafenib 的活性代谢物。Regorafenib 是多靶点抑制剂,包括VEGFR1/2/3,PDGFRβ,Kit,RET 和 Raf-1 , IC50分别是 13/4.2/46,22,7,1.5 和 2.5 nM。 | |||
T2671 |
Regadenoson
CVT-3146,瑞加德松,Lexiscan |
Adenosine Receptor | GPCR/G Protein; Neuroscience |
Regadenoson (CVT-3146) 是一种腺苷衍生物和选择性 A2A 腺苷受体激动剂,具有冠状动脉舒张活性,对大鼠和猪腺苷 A2A 受体的Ki 分别为 290 和 1120 nM。它是血管扩张剂,可增加啮齿动物血脑屏障的通透性。 | |||
T131419 | 3,14,20-trihydroxypregn-5-en-15-one | ||
3,14,20-trihydroxypregn-5-en-15-one 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T131419。 | |||
T64090 | Regorafenib mesylate | ||
Regorafenib (BAY 73-4506) mesylate 是一种口服具有活力的多靶点受体酪氨酸激酶 (tyrosine kinase) 抑制剂,能够抑制VEGFR1/2/3 (IC50=13/4.2/46 nM),PDGFRβ (IC50: 22 nM),Kit (IC50: 7 nM),RET (IC50: 1.5 nM) 和 Raf-1 (IC50: 2.5 nM)。Regorafenib mesylate 具有强大的抗肿瘤和抗血管生成作用。 | |||
T76851 | Regdanvimab | ||
Regdanvimab (CT-P59),一种靶向SARS-CoV-2刺突蛋白受体结合域的人单克隆抗体,通过阻断与ACE2的相互作用来防止病毒进入,适用于COVID-19研究。 | |||
T76528 |
Hepatitis b virus pre-s region (120-145)
|
||
Hepatitis b virus pre-s region (120-145) 是一种 preS2 肽,可抑制单链 Fv 片段 (scFv) 或IgG 与 r-HBsAg 的结合。 | |||
T80555 |
Myoregulin TFA
MLN peptide TFA |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Myoregulin (MLN peptide) TFA,作为调节蛋白家族成员,通过干预细胞内钙处理机制来调控肌肉功能。该化合物直接作用于肌浆网 Ca2+-ATPase (SERCA),抑制其将Ca2+传输至肌浆网。 | |||
T76237 |
Utreglutide
|
||
Utreglutide 是一种有效的胰高血糖素样肽 1(GLP-1)受体激动剂。 | |||
T68702 |
Photoregulin3
|
||
Photoregulin3 is a inhibitor of rod photoreceptor gene expression, potentially though Nr2e3 modulation. | |||
T131440 |
21-(acetyloxy)pregna-5,17-dien-3-yl acetate
|
||
21-(acetyloxy)pregna-5,17-dien-3-yl acetate 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T131440。 | |||
T124669 |
Spongipregnoloside A
|
||
T131412 |
20-oxopregna-5,14-dien-3-yl acetate
|
||
20-oxopregna-5,14-dien-3-yl acetate 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T131412。 | |||
T131420 |
pregn-2-en-20-yl acetate
|
||
pregn-2-en-20-yl acetate 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T131420。 | |||
T23400 |
StemRegenin 1 (hydrochloride)
StemRegenin 1 (hydrochloride) (1227633-49-9 free base) |
Others | Others |
StemRegenin 1 is an aryl hydrocarbon receptor signaling antagonist (IC50: 127 nM in CD34+ cells). | |||
T34128 |
Pregabalin arenacarbil
|
||
Pregabalin arenacarbil is a gabamimetic. | |||
T22865 |
immunoglobulin light chain variable region fragment [Homo sapiens]
|
Others | Others |
Immunoglobulin light chain variable region fragment [Homo sapiens] is a fragment (Phe-Thr-Leu-Lys-Ile-Ser-Arg) on the variable region of the human immunoglobulin light chain. | |||
T28511 |
Reglitazar
JTT-501,JTT501,PNU-182716,PNU182716,PNU-716 |
||
Reglitazar is a PPARɑ agonist and PPARγ agonist. Reglitazar rapidly stimulates glucose disposal rates by enhancing insulin signal transduction in skeletal muscle. Reglitazar improves insulin resistance in genetic and non-genetic insulin-resistant models. | |||
T131415 | 3-hydroxypregna-5,17-dien-21-al | ||
3-hydroxypregna-5,17-dien-21-al 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T131415。 | |||
T83859 |
5α-Pregnane-3α,20α-diol
Allopregnanediol |
||
5α-Pregnane-3α,20α-diol是孕酮的一种活性代谢物。它通过5α-pregnane-20α-ol-3-one和5α-pregnane-3α-ol-20-one中间体从孕酮形成。5α-Pregnane-3α,20α-diol(10 µM)可提高洗涤后的孤立人类血小板中的细胞内钙水平。 | |||
T81600 |
Oregon-BAPTA Green 1AM
Oregon Green 488 BAPTA 1AM |
||
Oregon-BAPTA Green 1AM(Oregon Green 488 BAPTA 1AM)是一种荧光Ca2+指示剂,由绿色荧光探针OG 488和可透过细胞膜的Ca2+螯合剂BAPTA AM组成。 | |||
T78376 |
Rimtoregtide
|
||
Rimtoregtide为一多肽化合物,能显著下调急性胰腺炎致血液淀粉酶与脂肪酶水平升高。该化合物在胰腺炎及急性胰腺炎研究中具备潜力。 | |||
TP1761 |
Handle region peptide, rat
|
||
Handle region peptide, rat, functions as a prorenin receptor antagonist, effectively inhibiting the development of diabetic nephropathy while also exhibiting anti-inflammatory properties specifically within the eye. | |||
TP2259 |
immunoglobulin light chain variable region fragment [Homo sapiens]/[Mus musculus]
|
Others | Others |
Immunoglobulin light chain variable region fragment [Homo sapiens]/[Mus musculus] is a fragment on the variable region of the human and mouse immunoglobulin light chain. Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule | |||
T78291 |
Tregalizumab
BT-061 |
||
Tregalizumab为人源化抗CD4单克隆抗体(IgG1型),体外能选择性激活调节性T细胞(Tregs)功能。适用于研究自身免疫性疾病(因Treg功能不足)及过敏反应。 | |||
T35665 |
Pregnanetriol
|
||
Pregnanetriol is a metabolite of 17α-hydroxyprogesterone .1,2It is formed from 17α-hydroxyprogesterone by reduction of the C-20 ketone.2Urinary levels of pregnanetriol are elevated in patients with 21-hydroxylase deficiency and congenital adrenal hyperplasia.3,4 1.Kamrath, C., Hartmann, M.F., Boettcher, C., et al.Diagnosis of 21-hydroxylase deficiency by urinary metabolite ratios using gas chromatography-mass spectrometry analysis: Reference values for neonates and infantsJ. Steroid Biochem. Mol... | |||
T31837 |
FOLFIRI Regimen
FOLFIRI |
||
FOLFIRI Regimen is a chemotherapy regimen consisting of leucovorin calcium (calcium folinate), 5-fluorouracil, and irinotecan used during the treatment of advanced-stage and metastatic colorectal cancer. | |||
T22856 |
IgG light chain variable region [Homo sapiens]/IgM/kappa antibody [Mus musculus]
|
Others | Others |
IgG has four forms, provides the majority of antibody-based immunity against invading pathogens. The only antibody capable of crossing the placenta to give passive immunity to the fetus. Eliminates pathogens in the early stages of B cell-mediated (humoral | |||
T12698 |
Regorafenib-d3
Regorafenib D3,BAY 73-4506 D3 |
Others | Others |
Regorafenib D3 is a deuterium labeled Regorafenib. Regorafenib is a multi-targeted receptor inhibitor of tyrosine kinase. | |||
T131429 |
3,20-dihydroxypregnan-6-one
|
||
3,20-dihydroxypregnan-6-one 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T131429。 | |||
T131405 |
3-(tetrahydro-2H-pyran-2-yloxy)pregnan-21-al
|
||
3-(tetrahydro-2H-pyran-2-yloxy)pregnan-21-al 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T131405。 | |||
T131617 | 17-hydroxypregn-4-ene-3,6-dione | ||
17-hydroxypregn-4-ene-3,6-dione 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T131617。 | |||
T129460 | Preglabridin | ||
Preglabridin 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T129460。 | |||
T19684 |
Pregnanolone
SKF 6455,Kabi-2213,Kabi 2213,Eltanolone,Kabi2213,SKF6455 |
||
Pregnanolone is a cell membrane modulator potentially for the treatment of pain. Pregnanolone is an endogenous neurosteroid that is biosynthesized from progesterone. It is a positive allosteric modulator of the GABAA receptor, as well as a negative allost |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12536 |
Pregnenolone monosulfate
3β-Hydroxy-5-pregnen-20-one monosulfate |
NMDAR | Neuroscience |
Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) 是一种强效神经类固醇,可正向调节 NMDA 记录,可用于研究神经分裂和抑郁症。 | |||
TN2139 |
Regaloside B
鸦胆子苦醇,王百合苷 B |
NOS; COX; NO Synthase | Immunology/Inflammation; Neuroscience |
Regaloside B 是从麝香百合中分离出来的一种苯丙烷,可抑制iNOS 和COX-2的表达,具有抗炎活性。 | |||
T0851 |
Pregnenolone
3β-Hydroxy-5-pregnen-20-one,Arthenolone,孕烯醇酮 |
Cannabinoid Receptor; Endogenous Metabolite; TRP/TRPV Channel; AChR; Autophagy | Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Pregnenolone (Arthenolone) 是一种由胆固醇合成的内源性类固醇激素,用于治疗阿尔茨海默病。它是大麻素 CB1受体的信号传导特异性抑制剂,抑制由 CB1受体介导的四氢大麻酚 的作用。它也是 TRPM3通道激活剂,也可弱激活 TRPM1通道。 | |||
TN7117 |
regaloside I
|
Others | Others |
Regaloside I 是百合中的单体成分,可能是保护人类皮肤成纤维细胞免受 UVA 诱导的形态变化的主要成分。 | |||
TN6490 |
Regaloside C
|
Others | Others |
Regaloside C 是一种从百合属的中分离出来的甘油葡糖苷,具有抗炎作用。 | |||
T5556 |
5a-Pregnane-3,20-dione
|
Endogenous Metabolite | Metabolism |
5a-Pregnane-3,20-dione 是内源性的孕酮代谢物。 | |||
T1688 |
Pregnanediol
5Beta-Pregnane-3Alpha,20alpha-Diol,孕甾二醇,Pregnandiol,孕二醇 |
Estrogen/progestogen Receptor; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
Pregnanediol (5Beta-Pregnane-3Alpha,20alpha-Diol) 是一种黄体酮的主要代谢物 (metabolite),能够通过尿液排出。它提供了一种间接测定体内孕激素水平的方法。 | |||
TC0019 |
Pregnenolone acetate
孕烯醇酮醋酸酯,3β-Hydroxy-5-pregnen-20-one acetate |
Cannabinoid Receptor; Endogenous Metabolite | GPCR/G Protein; Metabolism |
Pregnenolone acetate 是一种强大的神经类固醇,是各种类固醇激素(包括类固醇酮)的主要前体。它作为大麻素 CB1 受体的信号特异性抑制剂,抑制由 CB1 受体介导的四氢大麻酚 (THC) 的作用。它可以保护大脑免受大麻中毒。 | |||
TN6489 |
Regaloside A
|
Others | Others |
Regaloside A 是一种从百合中提取出的苯丙烷,在 160 ppm 时显示出 DPPH 自由基清除活性。Regaloside A 具有抗炎活性和抗抑郁活性。 | |||
TN7038 |
Regaloside H
|
Others | Others |
Regaloside H 是一种糖异生抑制剂,是一种苯丙酸甘油糖苷。它能够抑制大鼠肝癌细胞中葡萄糖的产生。 | |||
T13518 |
5α-Pregnane-3β,6α-diol-20-one
|
Others | Others |
5α-Pregnane-3β,6α-diol-20-one 是促进有丝分裂的 progesterone 代谢物,可于血清不足时雄性激素反应的前列腺素癌细胞中产生。 | |||
T7931 |
16a,17a-Epoxy-4-Pregnen-3,20-Dione
|
Others | Others |
16a,17a-Epoxy-4-Pregnen-3,20-Dione 是一种合成孕激素,是黄体酮激素的代谢产物,它通过与黄体酮受体结合发挥作用,已被用于研究孕激素对生殖器官的影响,激素对细胞生长和发育的影响,以及激素对免疫系统的影响。 | |||
T7646 |
Alloepipregnanolone
|
Endogenous Metabolite | Metabolism |
Alloepipregnanolone 是具有促进安定和睡眠的孕酮,可干扰乙醇抗焦虑作用的快速耐受。 | |||
T10048 |
17a-Hydroxypregnenolone
|
Endogenous Metabolite | Metabolism |
17a-Hydroxypregnenolone 是一种孕烷类固醇, 是形成脱氢表雄酮的激素原。 | |||
T13489 | 21-Hydroxypregnenolone | Others | Others |
21-Hydroxypregnenolone is an essential intermediate in corticosterone synthesis. | |||
TN5295 |
Dregeoside A11
|
||
Dregeoside A11 is a natural product from Dregea volubilis. | |||
T81303 |
Regaloside E
|
||
Regaloside E为自Lilium longiflorum Thunb. 提取的天然化合物。 | |||
T26055 |
Regelin
Regelin C |
||
Regelin is an antitumor ursene-type triterpenoid isolated from Tripterygium regelii. | |||
TN4821 |
Pregomisin
|
PAFR | GPCR/G Protein |
Pregomisin shows platelet-activating factor (PAF) antagonistic activity and the IC 50 value is 4.8x10(-5) M. | |||
T16574 |
Pregnenolone monosulfate sodium salt
3β-Hydroxy-5-pregnen-20-one monosulfate sodium salt |
Others | Others |
Pregnenolone monosulfate sodium salt is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium salt can protect the brain from cannabis intoxication. Pregnenolone monosulfate sodi | |||
TN5310 |
Pregn-5-ene-3β,17α,20S-triol
(3β,17α,20S)-Pregn-5-ene-3,17,20-triol |
||
Pregn-5-ene-3β,17α,20S-triol 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5310,CAS号为 903-67-3。 | |||
TN4903 | Regiolone | Caspase | Apoptosis; Proteases/Proteasome |
Regiolone demonstrates phytotoxicity. Regiolone also has anti-proliferative and apoptotic activities, it can induce apoptosis in MCF-7 cells through the caspase-3 independent pathway. | |||
TN2140 |
Regaloside D
王百合苷,王百合苷D |
Others | Others |
Regaloside D 是一种分离于 Lilium Longiflorum 的苯丙素。 | |||
TN5715 |
Oregonin
|
||
Oregonin 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5715,CAS号为 55303-93-0。 | |||
TN3804 | Dehydroformouregine | Others | Others |
Dehydroformouregine是一种天然产物,属于胡椒科胡椒属,其产品编号为 TN3804,CAS号为 107633-69-2。Dehydroformouregine可用作对照参考。 | |||
TN3892 |
Dregeoside Aa1
|
Others | Others |
Dregeoside Aa1 is a natural product from Dregea volubilis. | |||
TN3893 |
Dregeoside Da1
|
Others | Others |
Dregeoside Da1 is a natural product from Dregea volubilis. | |||
T81302 |
Regaloside K
|
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Regaloside K (Compd 1) 是从Easter Lily (Lilium longiflorum Thunb.) 提取的天然化合物。 | |||
T38592 | Regaloside F | ||
Regaloside F is a phenolic glycerol glucoside that can be found in Lily bulbs. | |||
TN2141 | Regelidine | Others | Others |
Regelidine 是一种天然产物,分离自雷公藤茎中。 | |||
TN5293 | Dregeoside Ga1 | ||
Dregeoside Ga1 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5293,CAS号为 98665-66-8。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-03673 |
REG3B Protein, Mouse, Recombinant (His)
Pap,HIP,REG-III,PAP1 |
Mouse | HEK293 Cells |
Expression of REG3B was sufficient to inhibit cytokine-induced activation of STAT3 in IECs. The human REG3beta protein, the functional counterpart of mouse REG3B, inhibited STAT3 activity in human 293T cells, and its expression level in colorectal tumors correlated inversely with pSTAT3 level and survival times of patients. REG3B negatively regulates cytokine-induced activation of STAT3 in colon epithelial cells. This pathway might be targeted in patients with colitis to reduce carcinogenesis. | |||
TMPY-03693 |
REG4 Protein, Human, Recombinant (hFc)
regenerating islet-derived family, member 4,GISP, |
Human | HEK293 Cells |
REG4 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 59.7 kDa and the accession number is Q9BYZ8-1. | |||
TMPY-03092 |
REG1A Protein, Rat, Recombinant (hFc)
Reg,REG1A,regenerating family mem... |
Rat | HEK293 Cells |
REG1A Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 35.8 kDa and the accession number is P10758. | |||
TMPY-01406 |
REG3G Protein, Human, Recombinant (His)
UNQ429,PAP-1B,LPPM429,REG-III,regenerating... |
Human | HEK293 Cells |
Regenerating gene (Reg), first isolated from a regenerating islet cDNA library, encodes a secretory protein with a growth stimulating effect on pancreatic beta cells. Reg and Reg-related genes which were expressed in various organs have been revealed to constitute a multigene family, the Reg family, which consists of four subtypes (types I, II, III, IV) based on the primary structures of the encoded proteins of the genes, which are associated with tissue repair and have been directly implicated ... | |||
TMPJ-00057 |
REG3G Protein, Human, Recombinant (hFc)
PAP-1B,REG3G,Regenerating islet-derived pr... |
Human | HEK293 Cells |
Pancreatitis-associated protein IB, Regenerating islet-derived protein III-gamma, is a secreted protein which contains 1 C-type lectin domain. It is expressed almost exclusively in the pancreas and also expressed in testis, but not found in small intestine. This protein might be a stress protein involved in the control of bacterial proliferation. | |||
TMPY-01336 |
REG3A Protein, Human, Recombinant (His)
HIP/PAP,INGAP,REG3,PAP1,PAP-H,regenerating... |
Human | HEK293 Cells |
REG3A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18 kDa and the accession number is Q06141-1. | |||
TMPY-01335 |
REG1A Protein, Human, Recombinant (His)
regenerating family member 1 alpha,P19,MGC12447, |
Human | HEK293 Cells |
REG1A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.7 kDa and the accession number is P05451. | |||
TMPY-05474 |
REG1A Protein, Human, Recombinant (His), Biotinylated
PSPS,R EG,PSPS1,MGC12447,ICRF,REG1A,regene... |
Human | HEK293 Cells |
REG1A Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.7 kDa and the accession number is P05451. | |||
TMPY-03716 |
REG2 Protein, Mouse, Recombinant (hFc)
RegII,REG2,regenerating islet-der... |
Mouse | HEK293 Cells |
REG2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.6 kDa and the accession number is Q08731. | |||
TMPY-04119 |
REG2 Protein, Mouse, Recombinant (His)
RegII,regenerating islet-derived 2,REG... |
Mouse | HEK293 Cells |
REG2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18.3 kDa and the accession number is Q08731. | |||
TMPY-03614 |
PSME3 Protein, Human, Recombinant (His)
PA28G,PA28-gamma,HEL-S-283,REG-GAMMA,proteasome (pr... |
Human | E. coli |
PSME3, also known as PA28-gamma, is a subunit of proteasome. The 26S proteasome multicatalytic proteinase complex has a highly ordered structure composed of 2 complexes, a 2S core and a 19S regulator. The 2S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 1 non-ATPase su... | |||
TMPY-02938 |
REG4 Protein, Rat, Recombinant (His)
regenerating islet-derived family, member 4 |
Rat | HEK293 Cells |
REG4 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.3 kDa and the accession number is Q68AX7. | |||
TMPY-03736 |
REG1B Protein, Rhesus, Recombinant (hFc)
regenerating islet-derived 1 beta,regenera... |
Rhesus | HEK293 Cells |
REG1B Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.2 kDa and the accession number is F6SR93. | |||
TMPY-03639 |
REG1A Protein, Cynomolgus, Recombinant (His)
regenerating family member 1 alpha,REG1A,<... |
Cynomolgus | HEK293 Cells |
REG1A Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 7.10 kDa and the accession number is G8F4F8. | |||
TMPY-03132 |
REG4 Protein, Rat, Recombinant (hFc)
regenerating islet-derived family, member 4 |
Rat | HEK293 Cells |
REG4 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.9 kDa and the accession number is Q68AX7. | |||
TMPY-03133 |
REG3A Protein, Rat, Recombinant (hFc)
Pap2,REG3A,regenerating family member 3 al... |
Rat | HEK293 Cells |
REG3A Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.4 kDa and the accession number is BAA04904.1. | |||
TMPY-01805 |
REG4 Protein, Mouse, Recombinant (His)
RELP,GISP,2010002L15Rik,regenerating islet-derived ... |
Mouse | HEK293 Cells |
REG4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.5 kDa and the accession number is Q9D8G5. | |||
TMPY-03134 |
REG3A Protein, Rat, Recombinant (His)
regenerating family member 3 α,Pap2,regene... |
Rat | HEK293 Cells |
REG3A Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.9 kDa and the accession number is BAA04904.1. | |||
TMPY-01090 |
REG3A Protein, Mouse, Recombinant (His)
regenerating family member 3 α,Rega3a,... |
Mouse | HEK293 Cells |
REG3A Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18 kDa and the accession number is O09037. | |||
TMPH-02019 |
REG3A Protein, Human, Recombinant (GST)
|
Human | E. coli |
Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway. REG3A Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 43.6 kDa and the accession number is Q06141. | |||
TMPY-03684 |
REG1A Protein, Cynomolgus, Recombinant (hFc)
regenerating family member 1 α,regeneratin... |
Cynomolgus | HEK293 Cells |
REG1A Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 38.3 kDa and the accession number is G8F4F8. | |||
TMPY-01847 |
REG3D Protein, Mouse, Recombinant (His)
Reg3d,regenerating islet-derived 3 delta,I... |
Mouse | HEK293 Cells |
Regenerating islet-derived 3 delta (REG3D) is a member of the secreted Reg superfamily and contains one typical C-type lectin domain. Regenerating gene (Reg), first isolated from a regenerating islet cDNA library, encodes a secretory protein with a growth stimulating effect on pancreatic beta cells. Reg and Reg-related genes which were expressed in various organs have been revealed to constitute a multigene family, the Reg family, which consists of four subtypes (types I, II, III, IV) based on t... | |||
TMPH-02879 |
REG3G Protein, Mouse, Recombinant (His)
|
Mouse | P. pastoris (Yeast) |
Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regula... | |||
TMPY-03478 |
REG1B Protein, Rhesus, Recombinant (His)
regenerating islet-derived 1 beta,regenera... |
Rhesus | HEK293 Cells |
REG1B Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.7 kDa and the accession number is F6SR93. | |||
TMPY-01394 |
REG1B Protein, Human, Recombinant (His)
regenerating islet-derived 1 beta,PSPS2,REG |
Human | HEK293 Cells |
REG1B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.7 kDa and the accession number is P48304. | |||
TMPH-03365 |
REG3A Protein, Rat, Recombinant (E.coli, His)
|
Rat | E. coli |
Bactericidal C-type lectin. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway. REG3A Protein, Rat, Recombinant (E.coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 20.5 kDa and the accession number is P35231. | |||
TMPH-02763 |
Lithostathine-1/Reg1 Protein, Mouse, Recombinant (His & SUMO)
|
Mouse | E. coli |
Lithostathine-1/Reg1 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPH-01923 |
Pro-neuregulin-1 Protein, Human, Recombinant (GST & His)
|
Human | E. coli |
Pro-neuregulin-1 Protein, Human, Recombinant (GST & His) is expressed in E. coli. | |||
TMPH-00296 |
Pregnancy-associated protein bPAP Protein, Bovine, Recombinant (His & Myc)
|
Bovine | E. coli |
Pregnancy-associated protein bPAP Protein, Bovine, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 17.3 kDa and the accession number is P84291. | |||
TMPY-05813 |
Neuregulin-1/NRG1 Protein, Human, Recombinant , Biotinylated
HGL,NRG1-IT2,MST131,NDF,SMDF,neuregulin 1,HRG,GGF,G... |
Human | HEK293 Cells |
Neuregulin-1/NRG1 Protein, Human, Recombinant , Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 26.8 kDa and the accession number is Q02297. | |||
TMPY-00031 |
Neuregulin-1/NRG1 Protein, Human, Recombinant (His)
HRG1,GGF2,HRG,NDF,MSTP131,HRGA,GGF,neuregulin 1,HGL... |
Human | HEK293 Cells |
Neuregulin-1/NRG1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.3 kDa and the accession number is Q02297-12. | |||
TMPH-02214 |
Tomoregulin-1 Protein, Human, Recombinant (His)
|
Human | HEK293 Cells |
May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation. | |||
TMPY-00323 |
Hepatitis C virus (HCV-1a) NS3 protease/helicase immunodominant region Protein (aa 1356-1459, GST)
NS3 |
HCV | E. coli |
HCV NS3 displays three enzymatic activities: serine protease, NTPase, and RNA helicase. HCV NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A, and NS5A-NS5B. HCV NS3 RNA helicase binds to RNA and unwinds dsRNA in the 3' to 5' direction, and likely RNA stable secondary structure in the template strand (By similarity). Cleaves and inhibits the host antiviral protein MAVS. NS3/NS4A complex also prevents phosphorylation of human IRF3, t... | |||
TMPH-00037 |
Leukotoxin Protein, Aggregatibacter actinomycetemcomitans, Recombinant (His)
|
Aggregatibacter actinomycetemcomitans | P. pastoris (Yeast) |
Virulence factor that plays an important role in immune evasion. Lyses human lymphocytes and monocytes. Binds to the LFA-1 integrin on the surface of the host cell and to cholesterol-containing membranes, which probably results in large LtxA-LFA-1 clusters in lipid rafts. Shows also beta-hemolytic activity on certain types of growth media. Leukotoxin Protein, Aggregatibacter actinomycetemcomitans, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 38.3 kD... | |||
TMPH-01829 |
Human Papilloma Virus type 11 (HPV 11) Regulatory Protein E1 (His)
|
HPV 11 | E. coli |
Human Papilloma Virus type 11 (HPV 11) Regulatory Protein E1 (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.1 kDa and the accession number is P04014. | |||
TMPJ-00859 |
AREG Protein, Human, Recombinant
AR,CRDGF,Amphiregulin,Colorectum Cell-Derived Growt... |
Human | E. coli |
Amphiregulin (AREG) is a single-pass membrane protein with 252 amino acids. AREG belongs to the amphiregulin family, which contains 1 EGF-like domain. AREG is expressed in a variety of tissues including ovary, placenta, lung, kidney, stomach, colon, and breast. It is related to Epidermal Growth Factor (EGF) and Transforming Growth Factor Alpha (TGF-alpha). As an EGF-related growth factor, AREG interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits... | |||
TMPY-03902 |
Neuregulin-1/NRG1 Protein, Canine, Recombinant (mFc)
neuregulin 1 |
Canine | HEK293 Cells |
Neuregulin-1/NRG1 Protein, Canine, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 34 kDa and the accession number is XP_858147.1. | |||
TMPY-02169 |
Epiregulin Protein, Human, Recombinant (hFc)
ER,epiregulin |
Human | HEK293 Cells |
Epiregulin Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 33.8 kDa and the accession number is O14944. | |||
TMPH-01828 |
Human Papilloma Virus type 11 (HPV 11) Regulatory Protein E2 (His & Myc)
|
HPV 11 | E. coli |
Human Papilloma Virus type 11 (HPV 11) Regulatory Protein E2 (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 49.2 kDa and the accession number is P04015. | |||
TMPY-04202 |
Tomoregulin-1 Protein, Mouse, Recombinant (hFc)
M7365,transmembrane protein with EGF-like and two follistati... |
Mouse | HEK293 Cells |
TMEFF1 is a novel transmembrane protein, containing two follisatin domains and an epidermal growth factor-like region. The ectopic expression of TMEFF1 in brain cancer cells resulted in their growth inhibition. That TMEFF1 may behave as a tumor suppressor gene in brain cancers. TMEFF1 and TMEFF2 are putative transmembrane proteins comprised of one epidermal growth factor (EGF)-like domain and two follistatin-like domains. Both TMEFF1 and TMEFF2 are predominantly expressed in the brain. Tomoregul... | |||
TMPK-00820 |
AREG Protein, Human, Recombinant (hFc)
SDGF,AR,MGC13647,AREGB,CRDGF,Amphiregulin,... |
Human | HEK293 Cells |
Amphiregulin (AREG) is a member of the epidermal growth factor (EGF) family and is expressed in a plethora of cancers. Tumour growth and metastasis were decreased by AREG silencing in an orthotopic model of pancreatic cancer. AREG may play a critical role in cell migration, invasion, and EMT by activating the EGFR/ERK/NF‑κB signalling pathway in pancreatic cancer cells. | |||
TMPY-03943 |
Neuregulin-1/NRG1 Protein, Canine, Recombinant (hFc)
neuregulin 1 |
Canine | HEK293 Cells |
Neuregulin-1/NRG1 Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.8 kDa and the accession number is XP_858147.1. | |||
TMPH-02213 |
Tomoregulin-1 Protein, Human, Recombinant (E. coli, His)
|
Human | E. coli |
May inhibit NODAL and BMP signaling during neural patterning. May be a tumor suppressor in brain cancers. | |||
TMPY-03559 |
CREG1 Protein, Mouse, Recombinant (hFc)
cellular repressor of E1A-stimulated genes 1,Creg,A... |
Mouse | HEK293 Cells |
CREG1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48.5 kDa and the accession number is O88668. | |||
TMPY-00112 |
Tomoregulin-1 Protein, Human, Recombinant (hFc)
TR-1,C9orf2,transmembrane protein with EGF-like and two foll... |
Human | HEK293 Cells |
TMEFF1 is a novel transmembrane protein, containing two follisatin domains and an epidermal growth factor-like region. The ectopic expression of TMEFF1 in brain cancer cells resulted in their growth inhibition. That TMEFF1 may behave as a tumor suppressor gene in brain cancers. TMEFF1 and TMEFF2 are putative transmembrane proteins comprised of one epidermal growth factor (EGF)-like domain and two follistatin-like domains. Both TMEFF1 and TMEFF2 are predominantly expressed in the brain. Tomoregul... | |||
TMPY-04237 |
Neuregulin-1/NRG1 Protein, Canine, Recombinant (aa 176-240, His)
neuregulin 1 |
Canine | HEK293 Cells |
Neuregulin-1/NRG1 Protein, Canine, Recombinant (aa 176-240, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 9.7 kDa. | |||
TMPK-00870 |
AREG Protein, Mouse, Recombinant (hFc)
AR,MGC13647,CRDGF,AREG,Amphiregulin,SDGF,A... |
Mouse | HEK293 Cells |
Amphiregulin (AREG) is a ligand of the epidermal growth factor receptor (EGFR), a widely expressed transmembrane tyrosine kinase. AREG is synthesized as a membrane-anchored precursor protein that can engage in juxtacrine signaling on adjacent cells. Alternatively, after proteolytic processing by cell membrane proteases, mainly TACE/ADAM17, AREG is secreted and behaves as an autocrine or paracrine factor. | |||
TMPH-01924 |
Pro-neuregulin-3 Protein, Human, Recombinant (His & SUMO)
|
Human | E. coli |
Pro-neuregulin-3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPY-00479 |
Neuregulin-1/NRG1 Protein, Human, Recombinant (hFc)
ARIA,neuregulin 1,GGF2,MSTP131,GGF,MST131,HGL,NDF,S... |
Human | HEK293 Cells |
Neuregulin-1/NRG1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 35.5 kDa and the accession number is Q02297-12. | |||
TMPY-02166 |
Epiregulin Protein, Mouse, Recombinant (hFc)
epiregulin,EPR |
Mouse | HEK293 Cells |
Epiregulin Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 33.8 kDa and the accession number is Q61521. | |||
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