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Search Results for " plasmodium "

103

抑制剂 & 化合物

37

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T12438	PfDHODH-IN-1	Dehydrogenase; Parasite	Metabolism; Microbiology/Virology
	PfDHODH-IN-1 是 Leflunomide 活性代谢物的类似物，具有抗疟疾活性。它是恶性疟原虫二氢乳清酸脱氢酶抑制剂。
T12909	SID 26681509	Cysteine Protease; Parasite	Microbiology/Virology; Proteases/Proteasome
	SID 26681509 是可逆的，竞争性的人组织蛋白酶 L 选择性抑制剂，IC50为 56 nM。它抑制Plasmodium falciparum 的体外繁殖，IC50为15.4 μM，抑制Leishmania major，IC5012.5 μM。
T8767	PfDHODH-IN-2	Dehydrogenase; Parasite	Metabolism; Microbiology/Virology
	PfDHODH-IN-2 是一种二氢噻吩酮衍生物，是一种有效的恶性疟原虫二氢乳清酸脱氢酶抑制剂，其IC50值为 1.11 µM。它具有抗疟作用，可研究疟疾。
T1491	Atovaquone Atavaquone,阿托伐醌	Others; P450; Dehydrogenase; Antibiotic; Parasite	Metabolism; Microbiology/Virology; Others
	Atovaquone (Atavaquone) 是具有口服活性的选择性寄生虫线粒体细胞色素bc1复合物的抑制剂。它抑制人类和P. falciparum 细胞色素bc1活性，IC50值分别为 460 nM 和 2.0 nM。它有抗疟作用，有潜力用于疟疾、弓形体病、肺孢子虫肺炎和巴贝斯虫病的相关研究。
T5421	KDU691	Parasite; PI4K	Microbiology/Virology; PI3K/Akt/mTOR signaling
	KDU691 是一种咪唑吡嗪类药物，对血阶段的裂殖体、配子体和肝期具有较强的抗寄生虫活性，它是 PI4K 抑制剂，选择性抑制双氢青蒿素预处理的恶性疟原虫。
T16269	Nanaomycin A	DNA Methyltransferase; Dehydrogenase; Parasite	Chromatin/Epigenetic; Metabolism; Microbiology/Virology
	Nanaomycin A 是一种醌类抗生素，可重新激活人类癌细胞中沉默的肿瘤抑制基因。 Nanaomycin A 是 DNMT3B 的特异性抑制剂 (IC50 = 500 nM)。
T13246	UCT943	Parasite; PI4K	Microbiology/Virology; PI3K/Akt/mTOR signaling
	UCT943是恶性疟原虫PI4K 的抑制剂（IC50 = 23 nM）。
T10378	Artelinic acid	Others	Others
	Artelinic acid, a derivative of Artemisinin, is an antimalarial drug for the treatment of multidrug-resistant strains of Plasmodium falciparum.
T40417	Ethylhydrocupreine hydrochloride Optochin hydrochloride,乙氢去甲奎宁盐酸盐；奥普托欣盐酸盐	Antibacterial; Parasite	Microbiology/Virology
	Ethylhydrocupreine hydrochloride (Optochin hydrochloride) 是奎宁的一种衍生物，具有抗菌作用，可抑制肺炎链球菌的活性。Ethylhydrocupreine hydrochloride 具有抗疟活性，对 Plasmodium falciparum 的IC50为 25.75 nM。Ethylhydrocupreine hydrochloride 是Gallus gallus2 受体 (ggTas2r1，ggTas2r2和ggTas2r7) 激动剂。
T10356	AQ-13 dihydrochloride	Parasite	Microbiology/Virology
	AQ-13 dihydrochloride 是一种氨基喹啉类抗疟药，对耐药型菌株 Plasmodium falciparum 有抑制作用。
T67694	ZY-19489	Parasite	Microbiology/Virology
	ZY-19489是一种具有抗疟作用的化合物，是一种潜在的单剂量根治性恶性疟原虫和间日疟原虫疟疾的药物，已获得美国 FDA 的孤儿药认定。
T14766	BPH-715	Others; Parasite	Microbiology/Virology; Others
	BPH-715 抑制恶性疟原虫的肝脏阶段生长，对 HepG2 细胞中的恶性疟原虫外红细胞的形成的 IC50 为 10 μM。
T3266	Lumefantrine Benflumetol,dl-Benflumelol,苯芴醇	Others; Parasite; Autophagy	Autophagy; Microbiology/Virology; Others
	Lumefantrine (dl-Benflumelol) 是一种抗疟药，用于治疗急性单纯性疟疾。与Artemether 联用，可提高疗效。
T4220	BQR-695 BQR695,NVP-BQR695	PI3K; Parasite; PI4K	Microbiology/Virology; PI3K/Akt/mTOR signaling
	BQR-695 (NVP-BQR695) 是一种磷脂酰肌醇 4-激酶抑制剂，对于人类和疟原虫 PI4KIIIβ 的 IC50值分别为 80 和 3.5 nM。
T11027	DHODH-IN-4	Dehydrogenase	Metabolism
	DHODH-IN-4 是人和 Plasmodium falciparum 二氢乳清酸脱氢酶 (DHODH) 的抑制剂，其对 PfDHODH 和 HsDHODH 的IC50 值分别为 4 μM 和 0.18 μM。DHODH-IN-4 (compound 17) 具有抗疟疾活性。
T21022	Deacylketoconazole Deacyl ketoconazole,脱乙酰酮康唑	Antifungal	Microbiology/Virology
	Deacylketoconazole (Deacyl ketoconazole) 是一种酮康唑衍生物，也是一种抗真菌剂。脱酰基酮康唑对恶性疟原虫的活性是酮康唑的 15 至 50 倍。
T10903	CWHM-1552	Parasite	Microbiology/Virology
	CWHM-1552 是一种有效的恶性疟原虫抑制剂。对于 3D7 和 Dd2 菌株，IC50 分别为 51 nM 和 53 nM。
T27400L	Ganaplacide phosphate Ganaplacide phosphate (1261113-96-5 Free base)	Others	Others
	Ganaplacide phosphate 对疟原虫症状性无性血期感染具有多阶段抗疟活性，并且能够在动物模型中预防传播和阻断感染。
T16125	MMV390048	Parasite; PI4K	Microbiology/Virology; PI3K/Akt/mTOR signaling
	MMV390048 是一种抗疟药，是一种新型化学疟原虫 PI4K 抑制剂。它与疟原虫 PI4K 的 ATP 结合位点结合，不与除人类 PIP4K2C 外的其他恶性疟原虫和人类激酶结合。
T79535	Antimalarial agent 30	Parasite	Microbiology/Virology
	Antimalarial agent 30 具有抗伯氏疟原虫肝期寄生虫活性和抗疟活性，可用于研究疟感染。
T5420	Cycloguanil hydrochloride Chloroguanide Triazine,环氯胍盐酸盐	Parasite; Drug Metabolite	Metabolism; Microbiology/Virology
	Cycloguanil hydrochloride (Chloroguanide Triazine) 是抗疟化合物氯胍的活性代谢物。它作为二氢叶酸还原酶的抑制剂，对于疟原虫和人类形式的 Kis 值分别为 0.3 和 1.5 nM。
T15276	Ferroquine SSR97193,Ferrochloroquine	Others	Others
	Ferroquine (Ferrochloroquine) 是 Chloroquine 的二茂铁基类似物，具有抗疟疾活性。Ferroquine 具有杀疟原虫作用，机制是通过诱导氧化应激和随后的膜破坏。
T9858	5-(3-bromo-4,5-dihydroisoxazol-5-yl)-3-(4-(tert-butyl)phenyl)-1,2,4-oxadiazole	Parasite	Microbiology/Virology
	Antileishmanial agent-2 是一种基于 3-Br-isoxazoline 的疟原虫抑制剂恶性疟原虫（D10 和 W2 菌株）和利什曼原虫属。 (L. infantum 和 L.tropica) 前鞭毛体，IC50 为 0.035、0.058、3.5 和 7.5 μM。
T17257L	WR99210 hydrochloride(47326-86-3 free base) WR99210 hydrochloride(47326-86-3 free base),6,6-Dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,6-dihydro-1,3,5-triazine-2,4-diamine	Others	Others
	WR99210 hydrochloride 是恶性疟原虫二氢叶酸还原酶 (pfDHFR) 的有效抑制剂，pfDHFR 是主要的疟疾药物靶点。它对野生型、双突变体和四突变体二氢叶酸还原酶具有亚纳摩尔效力。
T11558	Hexyl gallate 没食子酸己酯,Gallic acid hexyl ester,Hexyl 3,4,5-trihydroxybenzoate	Antibacterial	Microbiology/Virology
	Hexyl gallate (Gallic acid hexyl ester) 是没食子酸的烷基酯衍生物，对恶性疟原虫具有很强的抗疟活性，IC50为 0.11 mM。它具有抗菌活性，通过抑制 RhlR 抑制鼠李糖脂和绿脓杆菌素的产生。
T74696	SpdSyn binder-1	Parasite	Microbiology/Virology
	SpdSyn binder-1 是一种弱结合剂，结合在恶性疟原虫亚精胺合酶的活性位点，对疟疾有部分抑制作用，可用于研究疟疾。
T11030	DHODH-IN-8	Dehydrogenase	Metabolism
	DHODH-IN-8 是一种人和恶性疟原虫二氢乳清酸脱氢酶的抑制剂，IC50 分别为 0.13 μM 和 47.4 μM，Ki 分别为 0.016 μM 和 5.6 μM。DHODH-IN-8 具有抗疟疾能力。
T28824	SNX0723 SNX 0723,SNX- 0723	HSP	Cytoskeletal Signaling; Metabolism
	SNX0723 是一种 Hsp90 抑制剂，具有抗疟原虫活性。SNX0723 对 HsHsp90 和 PfHsp90 具有高结合亲和力，Ki 分别为 4.4 和 47 nM。SNX0723 抑制肝期伯氏疟原虫 ANKA 寄生虫，EC50 为 3.3 μM。
T4382	Proguanil hydrochloride Paludrine hydrochloride,盐酸氯胍,Chlorguanide hydrochloride,Chloroquanil	Others; Dehydrogenase; DNA/RNA Synthesis; Antifolate; Parasite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; Others
	Proguanil hydrochloride (Chloroquanil) 是一种双胍类抗疟疾剂，在体内代谢形成环胍。它还是一种二氢叶酸还原酶抑制剂。
T5493	Pyronaridine	Others	Others
	Pyronaridine 是一种具有口服活性的、含甘露醇的抗疟疾化合物，通过干扰红细胞内疟疾寄生虫(疟原虫)的复制而起作用。Pyronaridine 常与其他药联用来治疗疟疾，对对 P. falciparum 和 Echinococcus granulosus 具有抗感染活性。
T0049	Azlocillin sodium salt Sodium azlocillin,Azlocillin sodium,阿洛西林钠	Antibacterial; Antibiotic; Parasite	Microbiology/Virology
	Azlocillin sodium salt 是一种半合成青霉素，是内酰胺类广谱抗生素。它具有抗假单胞杆菌的活性，并对抗寄生虫Plasmodium falciparum 有效。
T0850	Primaquine diphosphate Primaquine phosphate,磷酸伯氨喹,Primaquine bisphosphate,磷酸伯安喹	Antibiotic; Parasite	Microbiology/Virology
	Primaquine diphosphate 是一种合成的 8-氨基喹啉衍生物，具有抗疟特性。它是一种能破坏间日疟原虫和卵形疟原虫肝脏晚期和潜在组织形态的化合物。
T30612	Bulaquine
	Bulaquine is a derivative of 8-aminoquinoline and has effective activity against the liver stage of plasmodium falciparum and the dormant bodies of Plasmodium vivax and Plasmodium ovale.
T33457	MMV007839 MMV-007839,MMV 007839
	MMV007839 is a potent Plasmodium lactate transporter PfFNT.
T25448	Genz-669178
	Genz-669178 is a wild-type inhibitor of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH).
T20910	Dibemethine Dibemetina,DBMA,AI3-26795,Dibemethinum
	Dibemethine is active against chloroquinone-resistant Plasmodium falciparum by the inhibition of P. falciparum chloroquine-resistance transporter (PfCRT).
T23935	D44 D 44,D-44
	D44 is a Plasmodium FKBPs inhibitor.
T71061	DSM267
	DSM267 is a novel Plasmodium falciparum Dihydroorotate Dehydrogenase (PfDHODH) Inhibitor.
T11331L	FTI 276	Others	Others
	FTI-276 is an inhibitor of protein farnesyltransferase (PFT) (IC50s: 0.9 and 0.5 nM for Plasmodium falciparum and human).
T40291	DSM705 DSM705
	DSM705 is a pyrrole-based inhibitor of Dihydroorotate Dehydrogenase (DHODH). It demonstrates high potency in the nanomolar range against Plasmodium DHODH and Plasmodium parasites, while not interfering with mammalian DHODHs. DSM705 shows significant efficacy as an antimalarial compound.
T40087	DSM502
	DSM502, a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor, demonstrates potent nanomolar activity against Plasmodium DHODH and Plasmodium parasites, while not inhibiting mammalian DHODHs.
T120656	N004-0015
	Plasmodium falciparum, EC50: 7.21 nM
T68421	MMV019662
	MMV019662 is a novel inhibitor of Plasmodium falciparum.
T24490	MMV666693 MMV-666693,MMV 666693
	MMV666693 is a selective allosteric Plasmodium Kinesin-5 inhibitor.
T25815	Mirincamycin HCl U24,729A,U-24,729A,U-24729 A,U 24729 A,U 24,729A,Mirincamycin hydrochloride
	Mirincamycin HCl is a close analog of the drug clindamycin used for the treatment of Plasmodium falciparum blood stages.
T23625	ACT-451840 ACT451840
	ACT-451840 is a drug of antimalarial activity. It has effective activity against sensitive and resistant Plasmodium falciparum strains.
T11331	FTI 276 TFA	Others	Others
	FTI 276 TFA is effective against plasmodium falciparum and humans.It is a protein-based nikyltransferase (PFT) inhibitor with an IC50s of 0.9 nM and 0.5 nM, respectively.
T25524	IDI-3783
	IDI-3783 is a mutant-selective inhibitor of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH).
T10902	CWHM-1008	Others	Others
	CWHM-1008 is an effective oral antimalarial drug. The EC50 values of the drug-sensitive Plasmodium falciparum 3D7 and drug-resistant Dd2 strains are 46 and 21 nM, respectively.
T61651	Quinoprazine
	Quinoprazine, a powerful inhibitor of Vaccinia virus DNA synthesis (IC50 = 10 μM), exhibits notable antimalarial activity against Plasmodium berghei. Additionally, it demonstrates significant antiprion potency, effectively reducing levels of PrPSc [1]-[5].

化合物

Cat.No: T12438

Target: Dehydrogenase, Parasite

Cat.No: T12909

Target: Cysteine Protease, Parasite

Cat.No: T8767

Target: Dehydrogenase, Parasite

Cat.No: T1491

Synonym: Atavaquone,阿托伐醌

Target: Others, P450, Dehydrogenase, Antibiotic, Parasite

Cat.No: T5421

Target: Parasite, PI4K

Cat.No: T16269

Target: DNA Methyltransferase, Dehydrogenase, Parasite

Cat.No: T13246

Target: Parasite, PI4K

Cat.No: T10378

Target: Others

Ethylhydrocupreine hydrochloride

Cat.No: T40417

Synonym: Optochin hydrochloride,乙氢去甲奎宁盐酸盐；奥普托欣盐酸盐

Target: Antibacterial, Parasite

AQ-13 dihydrochloride

Cat.No: T10356

Target: Parasite

Cat.No: T67694

Target: Parasite

Cat.No: T14766

Target: Others, Parasite

Cat.No: T3266

Synonym: Benflumetol,dl-Benflumelol,苯芴醇

Target: Others, Parasite, Autophagy

Cat.No: T4220

Synonym: BQR695,NVP-BQR695

Target: PI3K, Parasite, PI4K

Cat.No: T11027

Target: Dehydrogenase

Deacylketoconazole

Cat.No: T21022

Synonym: Deacyl ketoconazole,脱乙酰酮康唑

Target: Antifungal

Cat.No: T10903

Target: Parasite

Ganaplacide phosphate

Cat.No: T27400L

Synonym: Ganaplacide phosphate (1261113-96-5 Free base)

Target: Others

Cat.No: T16125

Target: Parasite, PI4K

Antimalarial agent 30

Cat.No: T79535

Target: Parasite

Cycloguanil hydrochloride

Cat.No: T5420

Synonym: Chloroguanide Triazine,环氯胍盐酸盐

Target: Parasite, Drug Metabolite

Cat.No: T15276

Synonym: SSR97193,Ferrochloroquine

Target: Others

5-(3-bromo-4,5-dihydroisoxazol-5-yl)-3-(4-(tert-butyl)phenyl)-1,2,4-oxadiazole

Cat.No: T9858

Target: Parasite

WR99210 hydrochloride(47326-86-3 free base)

Cat.No: T17257L

Synonym: WR99210 hydrochloride(47326-86-3 free base),6,6-Dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,6-dihydro-1,3,5-triazine-2,4-diamine

Target: Others

Cat.No: T11558

Synonym: 没食子酸己酯,Gallic acid hexyl ester,Hexyl 3,4,5-trihydroxybenzoate

Target: Antibacterial

SpdSyn binder-1

Cat.No: T74696

Target: Parasite

Cat.No: T11030

Target: Dehydrogenase

Cat.No: T28824

Synonym: SNX 0723,SNX- 0723

Target: HSP

Proguanil hydrochloride

Cat.No: T4382

Synonym: Paludrine hydrochloride,盐酸氯胍,Chlorguanide hydrochloride,Chloroquanil

Target: Others, Dehydrogenase, DNA/RNA Synthesis, Antifolate, Parasite

Cat.No: T5493

Target: Others

Azlocillin sodium salt

Cat.No: T0049

Synonym: Sodium azlocillin,Azlocillin sodium,阿洛西林钠

Target: Antibacterial, Antibiotic, Parasite

Primaquine diphosphate

Cat.No: T0850

Synonym: Primaquine phosphate,磷酸伯氨喹,Primaquine bisphosphate,磷酸伯安喹

Target: Antibiotic, Parasite

Cat.No: T30612

Cat.No: T33457

Synonym: MMV-007839,MMV 007839

Cat.No: T25448

Cat.No: T20910

Synonym: Dibemetina,DBMA,AI3-26795,Dibemethinum

Cat.No: T23935

Synonym: D 44,D-44

Cat.No: T71061

Cat.No: T11331L

Target: Others

Cat.No: T40291

Synonym: DSM705

Cat.No: T40087

Cat.No: T120656

Cat.No: T68421

Cat.No: T24490

Synonym: MMV-666693,MMV 666693

Mirincamycin HCl

Cat.No: T25815

Synonym: U24,729A,U-24,729A,U-24729 A,U 24729 A,U 24,729A,Mirincamycin hydrochloride

Cat.No: T23625

Synonym: ACT451840

Cat.No: T11331

Target: Others

Cat.No: T25524

Cat.No: T10902

Target: Others

Cat.No: T61651

Cat. No.	Product Name	Target	Signaling Pathways
T6S0084	Tuberostemonine 对叶百部碱,Tuberstemonine	Parasite	Microbiology/Virology
	Tuberostemonine (Tuberstemonine) 是一种生物碱，可作为抗疟疾剂，有较高的肠道通透性。
TN7103	13,21-Dihydroeurycomanone Pasakbumin C	Anti-infection; Parasite	Microbiology/Virology
	13,21-Dihydroeurycomanone (Pasakbumin C) 是从 Eurycoma longifolia 根部分离得到的一种天然产物，有抗寄生虫活性。
TN2027	Oxysanguinarine 8-Oxosanguinarine,氧化血根碱,Hydroxysanguinarine	Parasite	Microbiology/Virology
	Oxysanguinarine (Hydroxysanguinarine) 是一种来自Meconopsis simplicifolia 的小檗生物碱，具有抗疟和抗血小板聚集活性，对登革热病毒具有潜在的抑制作用。
T3682	(-)-Catechin gallate (-)-Catechin 3-O-gallate,儿茶素没食子酸酯,几茶素没食子酸酯,(-)-Catechin 3-gallate	Others; COX	Immunology/Inflammation; Neuroscience; Others
	(-)-Catechin gallate ((-)-Catechin 3-O-gallate) 是绿茶儿茶素中的微量组分，可抑制COX-1和COX-2活性。它抑制人 Beta-secretase，对氯喹敏感的恶性疟原虫 NF54 和耐氯喹的恶性疟原虫 K1 具有抗疟原虫活性。
TN1190	14,15 β-Dihydroxyklaineanone 14,15beta-Dihydroxyklaineanone	Parasite	Microbiology/Virology
	14,15 β-Dihydroxyklaineanone（14,15beta-Dihydroxyklaineanone）从 Eurycoma longifolia 中分离得到的苦味素类化合物，具有抗肿瘤促进、抗血吸虫和杀疟原虫活性。
TN3790	Dehydroabietinol Pomiferin A,Dehydroabietyl alcohol	Antifection	Microbiology/Virology
	Dehydroabietinol (Pomiferin A) 在体外抑制红细胞中的氯喹敏感及氯喹抵抗型疟原虫，IC50为26-27 μM.
T0392	Artemisinin Qinghaosu,Artemisinine,Qinghaosu,NSC 369397,青蒿素,Artemisinine	HCV Protease; Ferroptosis; Akt; Parasite	Apoptosis; Cytoskeletal Signaling; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Artemisinin (Qinghaosu) 是一种倍半萜烯内酯，是从青蒿植物的地上部分分离的一种抗疟疾药物。它有神经保护和抗癌作用。
T3327	Artemotil SM-227,β-Arteether,Beta-Arteether,蒿乙醚,Arteether,(+)-Arteether	CXCR; CCR; Parasite	Autophagy; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology
	Artemotil (SM-227) 是一种新型的速效抗疟药，可研究耐Plasmodium falciparum 的恶性疟原虫疟疾，IC50值为 1.61 nM。
TN1019	Beta-mangostin β-Mangostin,beta-倒捻子素	Apoptosis; Antibacterial; Parasite	Apoptosis; Microbiology/Virology
	Beta-mangostin (β-Mangostin) 是存在 Cratoxylum arborescens 中的一种氧杂蒽酮类天然产物，有抗癌和抗菌活性，对结核分枝杆菌的 MIC 值为 6.25 μg/mL。它在体外有抗疟活性，对恶性疟原虫的 IC50值为 3.00 μg/mL。
T35749	Thymohydroquinone Thymoquinol	Antioxidant; Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
	Thymohydroquinone (Thymoquinol) 是中药材百里香、牛至和其他唇形科植物中含有的单萜酚类化合物。 Thymohydroquinone 抑制癌细胞生长、减少氧化应激和调节炎症反应，在无细胞实验中清除2,2-二苯基-1-picrylhydrazyl 自由基(IC50 = 2.4 μg/ml)，在浓度为1.6至6.4 μg/ml 的氧自由基吸收能力(ORAC)实验中，它的Trolox 当量值为2.6胸腺对苯二酚对A2780、OVCAR-8和CIS-A2780卵巢癌细胞(IC50分别为3.1、8.9和9.8 μM)和人卵巢永生化上皮细胞(IC50 = 14 μM)的生长有抑制作用，体外对恶性疟原虫也有抑制作用(IC50 = 15.9 μM)。
TN3466	Atherosperminine	cAMP; Calcium Channel; AChR; Parasite	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience
	Atherosperminine 是一种天然生物碱，在体外表现出抗疟原虫活性，IC50为 5.80 μM。它具有DPPH 自由基清除活性，其IC50值为 29.56 µg/mL。它对气管有非特异性的弛缓作用。它是一种良好的还原剂，具有螯合金属的能力。
T11681	Isochondrodendrine Isochondrodendrin	Others	Others
	Isochondodendrine has strong antiplasmodial activity against Plasmodium falciparum. Isochondrodendrine is a class of bisbenzylisoquinoline alkaloid isolated from Isolona ghesquiereina.
TN4314	Isonardoperoxide	Antifection	Microbiology/Virology
	Isonardoperoxide shows strong antimalarial activity against Plasmodium falciparum malaria (6.0 × 10-7 M).
TN3583	Canophyllal	Antifection	Microbiology/Virology
	Canophyllal shows antiplasmodial activity against the W2 strain of Plasmodium falciparum which is resistant to chloroquine and other antimalarial drugs.
TN2485	1,2-Dihydrotanshinone 1,2-Dihydrotanshinquinone	Antifection	Microbiology/Virology
	1,2 Dihydrotanshinquinone is active against both Trypanosoma brucei rhodesiense and Plasmodium falciparum.
TN1930	Methylenetanshinquinone	Antifection	Microbiology/Virology
	Methylenetanshinquinone shows antiplasmodial and antitrypanosomal activity, it is active against both Trypanosoma brucei rhodesiense and Plasmodium falciparum.
TN4666	Norcaesalpinin E	Antifection	Microbiology/Virology
	Norcaesalpinin E shows antimalarial activity against the malaria parasite Plasmodium falciparum FCR-3/A2 clone in vitro, with an IC50 value of 0.090 microM.
TN4717	Oplopanone	Antifection	Microbiology/Virology
	Oplopanone exhibits noteworthy anti-plasmodial activity against Plasmodium falciparum strain.
T11509	Guanfu base H Atisinium chloride	Others	Others
	Guanfu base H is a diterpenoid alkaloid isolated from Aconitum coreanum. It has antiplasmodial activity against the malarial Plasmodium falciparum strains TM4/8.2 (wild type) and K1CB1 (IC50s: 4 μM and 3.6 μM).
TN3563	Caesalmin B	Antifection	Microbiology/Virology
	Caesalmin B shows significant dose-dependent inhibitory effects on Plasmodium falciparum FCR-3/A2 growth in vitro.
TN5657	Goniotriol
	Goniotriol shows antimycobacterial activity against Mycobacterium tuberculosis (MIC =100 microg/mL). It exhibits antiplasmodial activity against Plasmodium falciparum (IC50=2.6 microg/mL). Goniotriol shows cytotoxicity against cancer cells, KB, BC1, NCI-H
T79984	Chaparrinone	Parasite	Microbiology/Virology
	Chaparrinone为苦木素类化合物，源自Eurycoma Harmandiana根部提取。该物质对Plasmodium falciparum和P-388细胞展示出抗疟及细胞毒效应，IC50值分别为0.037 μg/mL和0.34 μg/mL。
T75568	Z-Antiepilepsirine
	Z-Antiepilepsirine 是一种酰胺生物碱，存在于 Piper capense L.f 中。Z-Antiepilepsirine 显示抗疟原虫活性，对 PlasmodiumfalciparumW2 菌株的 IC50值为 27 µM。
TN2747	2-Acetoxy-3-deacetoxycaesaldekarin E	Antifection	Microbiology/Virology
	2-Acetoxy-3-deacetoxycaesaldekarin E shows significant dose-dependent inhibitory effects on Plasmodium falciparum FCR-3/A2 growth in vitro.
TN1442	Betulinic acid methyl ester	Antifection	Microbiology/Virology
	Betulinic acid methyl ester showed antiplasmodial activity against chloroquine-resistant Plasmodium falciparum parasites in vitro.It also inhibited B16 2F2 cell proliferation by induction of apoptosis.
TN4202	(-)-Heraclenol	Antifection	Microbiology/Virology
	(-)-Heraclenol shows in vitro anti-plasmodial activity against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum.(-)-Heraclenol has moderate antibacterial and antifungal activities.
TN2738	2,6-Dimethoxy-1-acetonylquinol	Antifection	Microbiology/Virology
	2,6-Dimethoxy-1-acetonylquinol shows varying degrees of in vitro antimalarial activity against Plasmodium falciparum. It is devoid of significant cytotoxicity to the human oral epidermoid KB cancer cell line.
TN4716	Oplodiol	Influenza Virus	Microbiology/Virology
	Oplodiol exhibits noteworthy anti-plasmodial activity against Plasmodium falciparum strains. Oplodiol has a stimulative effect on significantly proliferation and differentiation of culture osteoblasts; it also shows moderate cytotoxic effects on the human
TN3124	5-Hydroxysophoranone	Antibacterial; Parasite; Antifection	Microbiology/Virology
	5-Hydroxysophoranone 从 Erythrina subumbrans 茎中提取，对恶性疟原虫具有高抗疟原虫活性 (IC50 = 2.5 μg/mL)。
T1235L	Lincomycin U 10149,U10149,U-10149
	Lincomycin is a lincosamide antibiotic that comes from the actinomycete Streptomyces lincolnensis. Although similar in structure, antibacterial spectrum, and mechanism of action to macrolides, lincomycin is also effective against other organisms including
T11802	L-Canaline	Others	Others
	L-Canaline, a nonprotein amino acid found in many leguminous plants, exhibits potent anticancer and antiproliferative effects. It effectively inhibits the growth of the malaria parasite Plasmodium falciparum with an IC50 of 297 nM. Additionally, L-Canaline acts as a cytotoxic metabolite produced from L-canavanine through arginase catalysis and serves as a potent and irreversible inhibitor of ornithine aminotransferase.
T75450	P-orlandin
	P-orlandin，一种真菌代谢产物，具有阻止FREP1与其配子体或[卵动细胞]结合的功能。该化合物能有效抑制蚊子体内的恶性疟原虫感染。
T75447	Asperaculane B
	Asperaculane B，一种真菌代谢产物，以IC50 7.89 µM抗恶性疟原虫传播，同时以IC50 3 µM抑制无性恶性疟原虫的发育，对人类细胞无毒。
TN4113	Garcinone E	Antifection	Microbiology/Virology
	Garcinone E is active constituents in the anticomplement assay used. Garcinone E exhibits potent activity in vitro against Plasmodium falciparum chloroquine-resistant strain W2, with IC50 values below 3 µM. It has potent cytotoxic effect on all hepatocellular carcinomas cell lines as well as on the other gastric and lung cancer cell lines included in the screen, may be potentially useful for the treatment of certain types of cancer.
TN5474	Bonducellin
	Bonducellin has anti-inflammatory activities, it can significantly and dose-dependently inhibit the inflammatory mediators; nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12. Bonducellin shows weak antimalarial ac
TN4449	Longistylin C	Antifection	Microbiology/Virology
	Longistylin A and longistylin C show some cytotoxic effects, with IC(50) values of 0.7-14.7 microM against the range of cancer cell lines. Longistylin A and longistylin C, and betulinic acid show a moderately high in vitro activity against the chloroquine
TN4683	Nyasol	ERK; IL Receptor; IκB/IKK; NOS; NF-κB; Akt; Antifection	Cytoskeletal Signaling; Immunology/Inflammation; MAPK; Microbiology/Virology; NF-κB; PI3K/Akt/mTOR signaling
	Nyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells. Nyasol shows anti-inflammatory properties by inhibiting iNOS expression; it also has antifungal activity, it is significantly

天然产物

Tuberostemonine

Cat.No: T6S0084

Synonym: 对叶百部碱,Tuberstemonine

Target: Parasite

13,21-Dihydroeurycomanone

Cat.No: TN7103

Synonym: Pasakbumin C

Target: Anti-infection, Parasite

Oxysanguinarine

Cat.No: TN2027

Synonym: 8-Oxosanguinarine,氧化血根碱,Hydroxysanguinarine

Target: Parasite

(-)-Catechin gallate

Cat.No: T3682

Synonym: (-)-Catechin 3-O-gallate,儿茶素没食子酸酯,几茶素没食子酸酯,(-)-Catechin 3-gallate

Target: Others, COX

14,15 β-Dihydroxyklaineanone

Cat.No: TN1190

Synonym: 14,15beta-Dihydroxyklaineanone

Target: Parasite

Dehydroabietinol

Cat.No: TN3790

Synonym: Pomiferin A,Dehydroabietyl alcohol

Target: Antifection

Cat.No: T0392

Synonym: Qinghaosu,Artemisinine,Qinghaosu,NSC 369397,青蒿素,Artemisinine

Target: HCV Protease, Ferroptosis, Akt, Parasite

Cat.No: T3327

Synonym: SM-227,β-Arteether,Beta-Arteether,蒿乙醚,Arteether,(+)-Arteether

Target: CXCR, CCR, Parasite

Cat.No: TN1019

Synonym: β-Mangostin,beta-倒捻子素

Target: Apoptosis, Antibacterial, Parasite

Thymohydroquinone

Cat.No: T35749

Synonym: Thymoquinol

Target: Antioxidant, Reactive Oxygen Species

Atherosperminine

Cat.No: TN3466

Target: cAMP, Calcium Channel, AChR, Parasite

Isochondrodendrine

Cat.No: T11681

Synonym: Isochondrodendrin

Target: Others

Isonardoperoxide

Cat.No: TN4314

Target: Antifection

Cat.No: TN3583

Target: Antifection

1,2-Dihydrotanshinone

Cat.No: TN2485

Synonym: 1,2-Dihydrotanshinquinone

Target: Antifection

Methylenetanshinquinone

Cat.No: TN1930

Target: Antifection

Norcaesalpinin E

Cat.No: TN4666

Target: Antifection

Cat.No: TN4717

Target: Antifection

Cat.No: T11509

Synonym: Atisinium chloride

Target: Others

Cat.No: TN3563

Target: Antifection

Cat.No: TN5657

Cat.No: T79984

Target: Parasite

Z-Antiepilepsirine

Cat.No: T75568

2-Acetoxy-3-deacetoxycaesaldekarin E

Cat.No: TN2747

Target: Antifection

Betulinic acid methyl ester

Cat.No: TN1442

Target: Antifection

Cat.No: TN4202

Target: Antifection

2,6-Dimethoxy-1-acetonylquinol

Cat.No: TN2738

Target: Antifection

Cat.No: TN4716

Target: Influenza Virus

5-Hydroxysophoranone

Cat.No: TN3124

Target: Antibacterial, Parasite, Antifection

Cat.No: T1235L

Synonym: U 10149,U10149,U-10149

Cat.No: T11802

Target: Others

Cat.No: T75450

Cat.No: T75447

Cat.No: TN4113

Target: Antifection

Cat.No: TN5474

Cat.No: TN4449

Target: Antifection

Cat.No: TN4683

Target: ERK, IL Receptor, IκB/IKK, NOS, NF-κB, Akt, Antifection

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