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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13799 |
NQO1 substrate
|
NADPH | Metabolism |
NQO1 substrate 是一种高效的 NQO1 底物,具有潜在的抗肿瘤活性,可用于研究白血病。 | |||
T16342 |
KL1333
NQO1 activator 1 |
NADPH; Mitochondrial Metabolism | Metabolism |
KL1333 (NQO1 activator 1) 是口服NAD+调节剂,与 NAD(P)H: 醌氧化还原酶 1 作为底物反应。它改善线粒体脑肌病、乳酸酸中毒和中风样发作成纤维细胞的能量代谢和线粒体功能障碍。它对顺铂诱导的小鼠耳蜗培养耳毒性的保护作用。 | |||
T6798 |
Tretazicar
5-Aziridino-2,4-dinitrobenzamide,CB1954,NSC 115829 |
DNA Alkylator/Crosslinker; DNA Alkylation | DNA Damage/DNA Repair |
Tretazicar (NSC-115829) 是一种抗肿瘤前药,由 NAD(P)H 醌氧化还原酶 2 激活。它在酶促活化后生成细胞毒性双功能烷基剂,可以形成 DNA-DNA 链间交联。 | |||
T0153 |
Oltipraz
吡噻硫酮,NSC 347901,RP 35972 |
HIF/HIF Prolyl-Hydroxylase; HIV Protease; Reverse Transcriptase; Nrf2; HIF | Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; Microbiology/Virology; Proteases/Proteasome |
Oltipraz (RP 35972) 是一种 Nrf2的强效激活剂。它时间依赖性地抑制 HIF-1α激活,IC50为 10 μM,浓度 ≥ 10 μM 时完全消除 HIF-1α诱导。 | |||
T38901 |
Isobutyl-deoxynyboquinone
IB-DNQ,Isobutyl-deoxynyboquinone |
||
Isobutyl-deoxynyboquinone (IB-DNQ) is a selective substrate for NAD(P)H: quinone oxidoreductase (NQO1) and is utilized in anticancer research. | |||
T64057 |
Nampt-IN-8
|
||
Nampt-IN-8 是一种 NAMPT 抑制剂 (IC50: 0.183 μM),也是较好的 NQO1 底物。Nampt-IN-8 能够诱导活性氧 (ROS) 产生,并促使细胞凋亡 (apoptosis) 。 | |||
T61186 |
Antitumor agent-57
|
||
Antitumor agent-57 (Compound 3o) is a potent NQO1-directed antitumor compound. It effectively inhibits tumor cell growth, induces ROS generation, and promotes cell apoptosis [1]. | |||
T36358 |
Diminutol
|
||
Diminutol is a cell-permeable purine derivative that inhibits the NADP-dependent oxidoreductase, NQO1 (Ki = 1.72 μM), to destabilize microtubules and disrupt mitosis. At 50 μM, it directly affects tubulin polymerization in Xenopus egg extracts without interfering with the activity of Cdk1, DNA replication, or actin polymerization. | |||
T81984 |
Keap1-Nrf2-IN-10
|
||
Keap1-Nrf2-IN-10(compound 15)作为NQO1诱导剂展现出高效性。该化合物能够在γ辐照小鼠中抑制氧化应激,具体机制是通过降低肝脏MDA、ROS及NQO1水平。此外,Keap1-Nrf2-IN-10能显著提升受γ射线照射小鼠的生存率。 | |||
T83001 |
Antitumor agent-67
|
||
Antitumor agent-67 (compound 3) 是一种高选择性抗肿瘤化合物,针对癌细胞具备显著选择性毒性,且对正常细胞损害低。该化合物经 NQO1 激活后,有效地释放鬼臼毒素(Podophyllotoxin),以消灭肿瘤细胞。在 HepG2 异种移植肿瘤模型中,Antitumor agent-67 展现出强效的肿瘤抑制能力而无显著毒副作用。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5S1805 |
5,7-Dihydroxychromone
5,7-Dihydroxy-4H-Chromen-4-One,5,7-二羟基色酮,5,7-二羟基色原酮 |
Others; Virus Protease; PARP; Caspase; Nrf2 | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology; Others; Proteases/Proteasome |
5,7-Dihydroxychromone (5,7-Dihydroxy-4H-Chromen-4-One) 是一种Cudrania tricuspidata 的提取物,通过激活 Nrf2/ARE 信号对 6-OHDA 诱导的氧化应激和细胞凋亡发挥神经保护作用。它抑制 6-OHDA 诱导的 SH-SY5Y 细胞中活化的caspase-3,caspase-9以及切割的PARP 表达。 | |||
TN2272 |
Tigloylgomisin H
|
Nrf2 | Immunology/Inflammation |
Tigloylgomisin H 是分离自S. chinensis 果实中的木酚素。Tigloylgomisin H 能诱导小鼠肝癌细胞 Hepa1c1c7 中醌还原酶活性。Tigloylgomisin H 是单功能诱导剂,通过 Nrf2-ARE 途径特异性上调 II 期解毒酶 NQO1。Tigloylgomisin H 是潜在的肝癌预防剂。 | |||
T6S2099 |
Geraniin
|
Antioxidant; TNF | Apoptosis; oxidation-reduction |
Geraniin 是一种肿瘤坏死因子α释放抑制剂,其IC50值为 43 μM,具有抗肿瘤、抗炎和抗高血糖活性。 | |||
T0809 |
Dicoumarol
Dicumarol,双羟香豆素,双香豆素 |
Dehydrogenase; NADPH; PDK | Metabolism; PI3K/Akt/mTOR signaling |
Dicoumarol (Dicumarol) 是一种 NAD(P)H: 醌氧化还原酶 1 和PDK1的抑制剂,它们的IC50值分别为 0.37 和 19.42 μM。 | |||
T82305 |
Glucoarabin
|
||
Glucoarabin是一种硫代葡萄糖苷,具备生物活性。在Hepa1c1c7细胞内,Glucoarabin的水解产物能够上调NQO1,而对细胞色素P450 (CYP) 1A1的活性无显著作用。 | |||
TN3806 |
Dehydroglyasperin C
|
ERK; IκB/IKK; p38 MAPK; TNF; NF-κB; Akt; COX; PI3K; NADPH; DNA/RNA Synthesis; Nrf2; JNK; Autophagy | Apoptosis; Autophagy; Cell Cycle/Checkpoint; Cytoskeletal Signaling; DNA Damage/DNA Repair; Immunology/Inflammation; MAPK; Metabolism; Neuroscience; NF-κB; PI3K/Akt/mTOR signaling |
Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemopreventive, and neuroprotective activities, it has protective effects against chronic diseases | |||
TN1543 |
Cynaropicrin
|
IL Receptor; Others; TNF | Apoptosis; Immunology/Inflammation; Others |
Cynaropicrin is a potent activator of the AhR-Nrf2-Nqo1 pathway, and could therefore be applied to prevention of UVB-induced photo aging; it may be a potential anticancer agent against some leukocyte cancer cells such as lymphoma or leukemia, through pro- |