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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T23438 |
TC LPA5 4
|
LPA Receptor | GPCR/G Protein |
TC LPA5 4是LPA5受体的拮抗剂。 | |||
T15785 |
LPA1 receptor antagonist 1
LPA1 R antagonist 1 |
LPA Receptor | GPCR/G Protein |
LPA1 receptor antagonist 1(LPA1 R antagonist 1) 是一种具有选择性和高效性的溶血磷脂酸 (LPA1) 受体拮抗剂( IC50 : 25 nM),可用于研究特发性肺纤维化。 | |||
T83879 |
1-Arachidoyl Lysophosphatidic Acid sodium
1-Arachidoyl LPA,LPA(20:0),1-Eicosanoyl-Lysophosphatidic Acid |
||
1-花生四烯酰基溶血磷脂酸(1-arachidoyl LPA)是溶血磷脂酸受体1(LPA1)的激动剂,并且是一种含有花生四烯酸的甘油磷脂,花生四烯酸位于sn-1位置。它能在主要表达LPA1而非LPA2-LPA6的人类肺成纤维细胞中诱导钙离子动员(EC50 = 3.6 µM)。在无细胞试验中,1-Arachidoyl LPA(2.5 µM)还能结合到过氧化物酶体增殖物激活受体γ(PPARγ)的配体结合域。人类尿液中也发现了该化合物。 | |||
T77789 |
Oleoyl-L-alpha-lysophosphatidic acid sodium salt
LPA sodium salt |
||
Oleoyl-L-alpha-lysophosphatidic acid sodium salt为必需的细胞膜生物合成代谢物,可通过与G蛋白偶联受体(GPCR)(即LPA受体)相互作用来介导信号传导,是LPA1和LPA2受体的内源性激动剂。 | |||
T31101 |
CRT0273750
CRT 0273750,CRT-0273750 |
PDE | Metabolism |
CRT0273750 是一种 ATX 抑制剂的先导化合物,可调节血浆中 LPA 水平,用于 ATX/LPA 依赖性癌症模型。 | |||
T36907 |
1-Oleoyl Lysophosphatidic Acid
Oleoyl-sn-3-Glycerophosphate,1-Oleoyl LPA,1-Oleoyl Lysophosphatidic Acid |
||
1-Oleoyl lysophosphatidic acid is a species of lysophosphatidic acid (LPA) containing oleic acid at the sn-1 position. Phosphatidic acid is produced either directly through the action of phospholipase D (PLD) or through a two step process involving liberation of diacylglycerol (DAG) by phospholipase C (PLC) followed by phosphorylation of DAG by diglycerol kinase.[1] Hydrolysis of the fatty acid at the sn-2 position by phospholipase A2 (PLA2) yields bioactive LPA. LPA binds to one of five differe... | |||
T22834 |
H2L 5765834
|
LPA Receptor; LPL Receptor | GPCR/G Protein |
H2L 5765834 是溶血磷脂酸受体 LPA1、LPA3和 LPA5拮抗剂,IC50值分别为 94、752 和 463 nM。 | |||
T11533 |
Z-HA155
CS-963 |
PDE | Metabolism |
Z-HA155 (CS-963) 是一种高效的 ATX 选择性抑制剂,其 IC50=5.7 nM。 | |||
T21654 |
1-Oleoyl lysophosphatidic acid sodium
1-Oleoyl lysophosphatidic acid sodium salt |
LPA Receptor | GPCR/G Protein |
1-Oleoyl lysophosphatidic acid sodium (1-Oleoyl lysophosphatidic acid sodium salt) salt 是 LPA1 和 LPA2 的内源性激动剂,可通过诱导 DNA 合成促进有丝分裂,参与正常和病理性情绪反应,如焦虑和抑郁。 | |||
T83772 |
1-Linoleoyl Lysophosphatidic Acid sodium
1-Linoleoyl-2-hydroxy-sn-glycero-3-PA,LPA(18:2),PA(18:2(9Z,12Z)/0:0),1-Octadecadienoyl-2-hydroxy-sn-glycero-3-phosphate,18:2 Lyso PA,1-Octadecadienoyl-2-hydroxy-sn-glycero-3-PA,PA(18:2/0:0),1-Linoleoyl-2-hydroxy-sn-glycero-3-phosphate,1-Linoleoyl LPA |
||
1-Linoleoyl LPA(1-亚油酰LPA)是LPA2受体的激动剂,属于一种含有亚油酸的甘油磷脂,在sn-1位置含亚油酸。它是小鼠和人体血浆中最丰富的LPA。1-Linoleoyl LPA在表达LPA2受体的Sf9细胞中选择性地增加细胞内钙水平(EC50约为10 nM),相较于表达LPA1和LPA3受体的Sf9细胞(EC50分别约为200和80 nM)。携带NCTC克隆2472肿瘤的小鼠中,1-linoleoyl LPA的血清水平增加。与患有初发进行性多发性硬化症的患者相比,复发缓解型多发性硬化症患者的血浆1-Linoleoyl LPA水平降低,且与神经功能缺损严重程度负相关。 | |||
T15786 |
LPA2 antagonist 1
|
Hydroxylase | Metabolism |
LPA2 antagonist 1 is an LPA2 antagonist (IC50: 17 nM). | |||
T11875 |
LPA2 antagonist 2
|
LPA Receptor | GPCR/G Protein |
LPA2 antagonist 2 is >480-fold more selective than LPA3 (IC50 of 13.85 μM).LPA2 antagonist 2 is a selective LPA2 antagonist with an IC50 of 28.3 nM and a Ki of 21.1 nM. | |||
T63231 | LPA5 antagonist 1 | ||
LPA5 antagonist 1 是选择性的、强效的 lysophosphatidic acid receptor 5(LPA5) 拮抗剂,IC50 值为32 nM。LPA5 antagonist 1 具有高脑渗透性和抗痛活性,能够用于研究炎症性和神经性疼痛。 | |||
T63172 | LPA5 antagonist 2 | ||
LPA5 antagonist 2 (compound 65) 是一种高水溶性的 LPA5 拮抗剂,可明显减轻痛觉。LPA5 antagonist 2 能够用于研究炎症性和神经性疼痛。 | |||
T1606 |
Fasudil
HA-1077,AT877,法舒地尔 |
ROCK; Serine/threonin kinase; Calcium Channel; PKA; PKC; Autophagy | Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Membrane transporter/Ion channel; Metabolism; Stem Cells; Tyrosine Kinase/Adaptors |
Fasudil (HA-1077) 是一种非特异性 RhoA/ROCK 抑制剂,也是 Ca2+通道拮抗剂和血管扩张剂。它对蛋白激酶有抑制作用,ROCK1 的 Ki 值为 0.33 μM,ROCK2 和 PKA、PKC、PKG 的 IC50值分别 0.158 μM 和 4.58 μM、12.30 μM、1.650 μM。 | |||
T3060 |
Fasudil hydrochloride
Fasudil (HA-1077) HCl,盐酸法舒地尔,HA-1077,Fasudil HCl,HA-1077 hydrochloride,AT-877 |
ROCK; Serine/threonin kinase; Calcium Channel; HIV Protease; PKA; PKC; Autophagy | Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Proteases/Proteasome; Stem Cells; Tyrosine Kinase/Adaptors |
Fasudil hydrochloride (HA-1077) 是一种非特异性RhoA/ROCK 抑制剂,也抑制蛋白激酶,对 ROCK1、PKA、PKC 和 MLCK 的 Ki 值分别为 0.33 μM、1.0 μM、9.3 μM 和 55 μM。 | |||
TP2056L |
Acetyl-Calpastatin (184-210)(human) acetate
Acetyl-Calpastatin (184-210) (human) acetate(123714-50-1 Free base ) |
Cysteine Protease | Proteases/Proteasome |
Acetyl-Calpastatin (184-210)(human) acetate 是一种有效,选择性和可逆的钙蛋白酶 (calpain) 抑制剂,对 μ-钙蛋白酶和组织蛋白酶 L 的 Ki 值分别为 0.2 nM 和 6 μM。 | |||
T4628 |
Seladelpar
MBX 8025 |
PPAR | DNA Damage/DNA Repair; Metabolism |
Seladelpar (MBX 8025) 是一种有效的,具有口服活性的, 特异性PPAR-δ激动剂,EC50为 2 nM。 | |||
T5670 |
Isobutylparaben
|
Others; Antibacterial | Microbiology/Virology; Others |
Isobutylparaben 是组成型雄烷受体激活剂,是一种广谱抗菌剂,用于个人护理产品和化妆品中。 | |||
T39516 |
Bocidelpar
|
PPAR | DNA Damage/DNA Repair; Metabolism |
Bocidelpar 是一种有效的过氧化物酶体增殖物激活受体 delta 调节剂,可改善杜兴肌营养不良肌肉细胞中的线粒体生物合成和功能。 | |||
T12527L |
Mavodelpar free acid hydrochloride
Mavodelpar free acid hydrochloride(942594-93-6 Free base),Pparδ agonist HCl,HPP593 free acid HCl,REN001 free acid HCl |
PPAR | DNA Damage/DNA Repair; Metabolism |
Mavodelpar free acid hydrochloride (Pparδ agonist HCl) 是一种有效的 PPARδ激动剂。 | |||
T5686 |
Isopropylparaben
|
Others | Others |
Isopropylparaben 是一种防腐剂和防腐杀虫剂。 | |||
T4165 |
Delpazolid
LCB01-0371 |
Antibacterial; Antibiotic | Microbiology/Virology |
Delpazolid (LCB01-0371) 是一种恶唑烷酮类新型抗生素,能抑制MSSA 和MRSA 的生长,对它们的MIC90值都为 2 μg/mL。 | |||
T3334 |
Velpatasvir
GS-5816,维帕他韦 |
HCV Protease; SARS-CoV | Microbiology/Virology; Proteases/Proteasome |
Velpatasvir (GS-5816) 是一种的 HCV NS5A 抑制剂。它也是 SARS-CoV 3CLpro 的抑制剂,IC50为 2.16 μM。 | |||
T25076 |
Amelparib
JPI289,JPI-289,JPI 289 |
||
Amelparib (JPI-289) is an inhibitor of the poly-ADP-ribose polymerase. | |||
T126544 | 3-O-Acetylpadmatin | ||
3-O-Acetylpadmatin 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T126544,CAS号为 100595-93-5。 | |||
T80531 |
Ac-AAVALLPAVLLALLAP-DEVD-CHO
DEVD-CHO-CPP 32 |
Caspase | Apoptosis; Proteases/Proteasome |
DEVD-CHO-CPP 32(Ac-AAVALLPAVLLALLAP-DEVD-CHO)是一种高效且可逆的caspase-3抑制剂。 | |||
T75794 |
Acetyl-Calpastatin(184-210)(human) TFA
|
||
Acetyl-Calpastatin(184-210)(human) TFA 是一种有效,选择性和可逆的钙蛋白酶 (calpain) 抑制剂,对 μ-钙蛋白酶和组织蛋白酶 L 的Ki 值分别为 0.2 nM 和 6 μM。 | |||
TP2380 |
Elpamotide
|
||
Elpamotide is a vaccine consisting of a VEGFR2-169 peptide. | |||
TP2056 |
Acetyl-Calpastatin(184-210)(human)
Acetyl-Calpastatin (184-210) (human) |
||
Selective calpain inhibitor. Strongly inhibits calpain I (Ki = 0.2 nM) and II but does not inhibit papain, trypsin and cathepsin L (Ki = 6 μM). Increases secretion of amyoid β-protein (Aβ) 42, Aβ40 and Aβ42 ratio. | |||
T80537 |
Ac-AAVALLPAVLLALLAP-LEHD-CHO
|
Caspase | Apoptosis; Proteases/Proteasome |
Ac-AAVALLPAVLLALLAP-LEHD-CHO 是半胱天冬酶4、5和9的抑制剂,能够对Neocarzinostatin处理的MCF-7细胞展现保护效果。 | |||
T21949 |
Calpain Inhibitor XII
|
||
(Rac)-Calpain Inhibitor XII是一种可逆的,选择性抑制钙蛋白酶I(calpain I; μ-calpain)的化合物,具有19 nM的Ki值。其对钙蛋白酶II(calpain II; m-calpain; Ki=120 nM)和组织蛋白酶B(cathepsin B; Ki=750 nM)显示出较低的抑制亲和力。(Rac)-Calpain Inhibitor XII用于研究钙蛋白酶在多种生理过程中的角色,如嗜中性粒细胞趋化性、神经元信号传导和心脏对损伤的响应。 | |||
T38931 |
Calpain Inhibitor-1
|
||
Calpain Inhibitor-1 (compound 36) is a highly potent and selective inhibitor of Calpain 1 (Cal1), which is a cysteine protease. It exhibits an IC50 value of 100 nM and a Ki value of 2.89 μM. | |||
T26182 |
Seladelpar lysine
MBX-8025 lysine dihydrate,MBX-8025 Lysine,MBX 8025 Lysine MBX8025 Lysine |
||
Seladelpar lysine, a selective PPAR-δ agonist, is used for the therapy of Homozygous Familial Hypercholesterolemia (HoFH). | |||
T71638 | Isomolpan hydrochloride | ||
Isomolpan hydrochloride is a dopamine receptor D2 agonist. | |||
T12876 |
Seladelpar sodium salt
RWJ-800025 sodium salt,MBX-8025 sodium salt |
Others | Others |
Seladelpar sodium salt (MBX-8025) 是一种具有口服活性、有效且特异性的PPARδ激动剂,EC50值为 2 nM。它对 PPARδ 的选择性分别是对 PPARα 和 PPARγ 的 750 和 2500 多倍。 | |||
T80241 |
Calpastatin subdomain B
|
Proteasome | Proteases/Proteasome; Ubiquitination |
Calpastatin subdomain B为具有生物活性的肽,其作用为抑制钙蛋白酶活性。 | |||
T80551 |
Calpain inhibitor V
Mu-Val-HPh-FMK |
Antibiotic | Microbiology/Virology |
Calpain inhibitor V (Mu-Val-HPh-FMK) 为具抗衣原体活性的细胞渗透性不可逆钙蛋白酶抑制剂。 | |||
T63391 |
Calpain Inhibitor-2
|
||
Calpain Inhibitor-2 是具有亲脂性的钙蛋白酶抑制剂,与黑色素瘤细胞系(A-375和B-16F1)和PC-3前列腺癌细胞相比,他们在体外具有中等到良好的抗增殖效果。Calpain Inhibitor-2 中的化合物3,在基质胶细胞侵袭测定中以2μM 浓度能够抑制了80%的DU-145细胞侵袭。 | |||
T33793 |
Olpadronic acid
Me2 APD,Me2-APD,Me2APD |
||
Olpadronic acid is a biochemical. | |||
T75158 | Olpasiran | ||
Olpasiran 是一种siRNA,可减少肝脏中脂蛋白 lipoprotein(a) 的合成。 | |||
T125997 | 17-Methylparsonsianidine | ||
17-Methylparsonsianidine 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T125997。 | |||
T77140 | Ralpancizumab | ||
Ralpancizumab 是一种 PCSK9选择性抑制剂,在出血性中风中有潜在应用。 | |||
T20590 |
Zilpaterol hydrochloride
|
||
Zilpaterol hydrochloride is a agonist of β-adrenergic receptor (AR). It is used to increase the feeding efficiency and the size of cattle. | |||
T72439 |
Calpain Inhibitor XI
|
||
Calpain Inhibitor XI,一种可逆的calpain-1共价抑制剂,适用于神经退行性疾病的研究。 | |||
T15336 |
Fonadelpar
NPS-005,SJP-0035 |
PPAR | DNA Damage/DNA Repair; Metabolism |
Fonadelpar is an agonist of PPARδ. It also is used in the research of neuroparalytic keratopathy. | |||
T124098 | 12a-Hydroxydalpanol | ||
12a-Hydroxydalpanol 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T124098,CAS号为 85042-77-9。 | |||
T39577 |
Fostroxacitabine bralpamide
MIV-818 |
||
Fostroxacitabine bralpamide (MIV-818) is an orally active Troxacitabine-based nucleotide prodrug. Fostroxacitabine bralpamide has anticancer effects. | |||
T77157 | Dilpacimab | ||
Dilpacimab (ABT165) 是一种有效的双可变结构域免疫球蛋白,靶向 delta 样配体 4 (DLL4) 和VEGF 通路。Dilpacimab 可用于癌症研究。 | |||
T73088 |
Mavodelpar
HPP593,REN001,REN001 ; HPP593 |
||
Mavodelpar (REN001) 是一种选择性的 PPARδ激动剂。Mavodelpar 抑制肾小球损伤和肾纤维化。Mavodelpar 可用于原发性线粒体肌病 (PMM) 和长链脂肪酸氧化障碍 (LC-FAOD) 的研究。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0834 |
Ethylparaben
Ethyl 4-hydroxybenzoate,Ethyl parahydroxybenzoate,羟苯乙酯,尼泊金乙酯 |
Antibacterial; Antifungal | Microbiology/Virology |
Ethylparaben (Ethyl parahydroxybenzoate) 是一种标准化的化学过敏原。 对羟基苯甲酸乙酯的生理作用是通过增加组胺释放和细胞介导免疫来实现的。 | |||
T3S2105 |
N-Benzylpalmitamide
Macamide 1,玛卡酰胺 B,N-苄基十六烷酰胺,N-Benzylhexadecanamide |
Others; FAAH; Autophagy | Autophagy; Metabolism; Neuroscience; Others |
N-Benzylpalmitamide (Macamide 1) 是从玛卡中得到的一种生物碱,可以时间依赖性方式抑制脂肪酸酰胺水解酶,有治疗疼痛、炎症和中枢神经系统退行性疾病的研究潜力。 | |||
T5557 |
Propylparaben
羟苯丙酯,Propyl 4-hydroxybenzoate,尼泊金丙酯,Propyl parahydroxybenzoate |
Apoptosis; Endogenous Metabolite; Antibacterial | Apoptosis; Metabolism; Microbiology/Virology |
Propylparaben (Propyl parahydroxybenzoate) 是一种由植物和细菌产生的抗菌防腐剂。它普遍用于化妆品,药品和食品中。它通过改变细胞周期,细胞凋亡和类固醇生成途径来破坏卵泡的生长和类固醇生成功能。它还可降低大鼠的精子数量和活动能力。 | |||
T6S1652 |
Benzoylpaeoniflorin
|
COX | Immunology/Inflammation; Neuroscience |
Benzoylpaeoniflorin 是一种从白芍中提取的天然化合物,可以降低细胞凋亡,对冠心病具有潜在的研究价值。 | |||
TN1067 |
Galloylpaeoniflorin
6'-O-Galloyl paeoniflorin,没食子酰芍药苷 |
NF-κB; Androgen Receptor; ROS | Endocrinology/Hormones; Immunology/Inflammation; NF-κB |
Galloylpaeoniflorin (6'-O-Galloyl paeoniflorin) 是 NF-κB 抑制剂,同时也是 DNA 裂解抑制剂。 | |||
T0927 |
Butylparaben
Butyl 4-hydroxybenzoate,Butyl parahydroxybenzoate,尼泊金丁酯,对羟基苯甲酸丁酯 |
Endogenous Metabolite; Antibacterial; Antibiotic | Metabolism; Microbiology/Virology |
Butylparaben (Butyl 4-hydroxybenzoate) 是一种标准化的化学过敏原,可增加组胺释放和细胞介导的免疫。 | |||
TN4688 | O-Methylpallidine | Others | Others |
O-Methylpallidine是一种天然产物,属于番荔枝科索木属,其产品编号为 TN4688,CAS号为 27510-33-4。O-Methylpallidine可用作对照参考。 | |||
T82594 | Debenzoylpaeoniflorgenin | ||
Debenzoylpaeoniflorgenin是从Paeonia lactiflora中分离得到的天然化合物,该植物是Guizhitang的一个组成成份。 | |||
TN2416 |
8-Debenzoylpaeoniflorin
|
Others | Others |
8-Debenzoylpaeoniflorin is a natural product from plants | |||
T40442 |
Propylparaben sodium
Propyl4-hydroxybenzoatesodium,羟苯丙酯钠,Propylparahydroxybenzoatesodium |
||
Propylparaben sodium (propyl parahydroxybenzoate) is a naturally occurring antimicrobial preservative found in plants and bacteria. Widely utilized in cosmetics, pharmaceuticals, and foods, this compound impairs antral follicle growth and steroidogenic function by modifying the cell-cycle, apoptosis, and steroidogenesis pathways. Additionally, propylparaben sodium reduces sperm count and motility in rats. | |||
TN5857 |
Debenzoylgalloylpaeoniflorin
|
||
Debenzoylgalloylpaeoniflorin 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5857,CAS号为 262350-51-6。 | |||
T83310 |
4-O-Methyldebenzoylpaeoniflorin
|
||
4-O-Methyldebenzoylpaeoniflorin为自Paeonia albiflora提取的自然化合物。 | |||
TN3607 | Catalpalactone | cAMP | GPCR/G Protein |
Catalpalactone exhibits high antitermitic, and cytotoxic activities, it exhibits potent inhibitory effects on lipopolysaccharide-induced NO synthesis in RAW 264.7 cells , with IC50 values of 9.80 microM. Catalpalactone can inhibit dopamine biosynthesis by | |||
TN5855 |
2'-O-Benzoylpaeoniflorin
|
||
2'-O-Benzoylpaeoniflorin 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5855,CAS号为 1456598-64-3。 |