52
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62
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T15372 |
GB1107
(2R,3R,4S,5R,6R)-2-(3,4-dichlorophenyl)sulfanyl-6-(hydroxymethyl)-4-[4-(3,4,5-trifluorophenyl)triazol-1-yl]oxane-3,5-diol |
Galectin | Immunology/Inflammation |
GB1107 是一种有效的选择性 Galectin-3 抑制剂,Kd 为 37 nM。 | |||
T77575 |
P-gb-IN-1
|
P-gp | Membrane transporter/Ion channel; Neuroscience |
P-gb-IN-1 是一种有效的 P-糖蛋白 (P-gp) 抑制剂,通过抑制 P-gp 外流展现出逆转活性。P-gb-IN-1 通过与残基 Asn 721 和 Met 986 形成氢键相互作用从而显示出对 P-gp 的抑制作用。P-gb-IN-1 在 MCF-7/ADR 细胞中显示出低毒性。 | |||
T11369 |
GB-110
|
Others | Others |
GB-110 selectively induces PAR2-mediated intracellular Ca2+ release in HT29 cells with an EC50 of 0.28 μM. GB-110 is a potent, orally active, and nonpeptidic protease activated receptor 2 (PAR2) agonist. | |||
T11369L |
GB-110 hydrochloride (1252806-70-4 free base)
GB-110 hydrochloride |
Others | Others |
GB-110 hydrochloride selectively induces PAR2-mediated intracellular Ca2+ release in HT29 cells with an EC50 of 0.28 μM. GB-110 hydrochloride is a potent, orally active, and nonpeptidic protease activated receptor 2 (PAR2) agonist. | |||
T11370 |
GB-88
|
Others | Others |
GB-88 is an selective , oral non-peptide antagonist of PAR2, inhibits PAR2 activated Ca2+ release with an IC50 of 2 μM. | |||
T27406 |
GB83
GB-83,GB 83 |
||
GB83 is a selective human protease activated receptor 2 (PAR2) antagonist. | |||
T8900 |
Seralutinib
GB002 |
PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Seralutinib (GB002) 是可吸入的PDGFRα 和 PDGFRβ激酶抑制剂,可用于研究肺动脉高压。 | |||
T80596 |
Coprelotamab
GB-221 |
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Coprelotamab (GB-221) 为针对EGFR2的IgG-κ类单克隆抗体。该化合物通常在CHO DG44 (中国仓鼠卵巢) 细胞中表达。 | |||
T80266 |
GB-6
|
Bombesin Receptor | GPCR/G Protein |
GB-6是一种短线性肽,专门针对胃泌素释放肽受体(GRPR)。该受体在胰腺癌细胞中高表达。由于GB-6具有肿瘤选择性和肿瘤特异性积累的特点,其结合近红外(NIR)荧光染料或99mTc标记后可作为提供高对比度的成像探针。此外,GB-6在体内具有良好稳定性,并在SW1990皮下异种移植模型中显示出5.2和6.3的高肿瘤/胰腺及肿瘤/肠道荧光信号比。因此,GB-6能迅速定位肿瘤并准确描绘其边界,展示出其在临床应用中的巨大潜力。 | |||
T71624 | GB1874 | ||
GB1874 inhibitor of the Wnt pathway that targets the β-cat-TCF4 PPI. GB1874 also affected the proliferation and stemness of Wnt-addicted colorectal cancer (CRC) cells in vitro. Encouragingly, GB1874 inhibited the growth of CRC tumor xenografts in vivo, thus demonstrating its potential for further development into therapeutics against Wnt-associated cancer indications. | |||
T73854 | GB-110 hydrochloride | ||
GB-110 hydrochloride 是一种有效的,具有口服活性的,非肽类的 protease activated receptor2 (PAR2)激动剂。GB-110 hydrochloride 选择性诱导 PAR2介导的 HT29 细胞内 Ca2+释放,EC50值为 0.28 μM。 | |||
T7776 |
ADH-503
GB1275 |
Complement System | Immunology/Inflammation |
ADH-503 (GB1275) 是一种可口服的变构CD11b 激动剂,可以导致与肿瘤相关的巨噬细胞重新极化,可减轻骨髓细胞的免疫抑制,并增强树突状细胞的反应。 | |||
TP1534 |
HSV-gB2 (498-505)
HSV-gB2 498-505 |
||
This is the immunodominant epitope gB-8p from herpes simplex virus (HSV) glycoprotein B (gB), amino acids 498 to 505. | |||
T16071 |
MGB-BP-3
|
Others | Others |
MGB-BP-3 is an antibiotic that demonstrates efficacy against a broad spectrum of multi-resistant Gram-positive pathogens. | |||
T1871 |
GBR 12935 dihydrochloride
GBR12935,GBR-12935,GBR 12935 |
Dopamine Receptor | GPCR/G Protein; Neuroscience |
GBR 12935 dihydrochloride (GBR 12935) 是一种多巴胺再吸收抑制剂。 | |||
T15373 |
Gboxin
|
ATPase; Mitochondrial Metabolism | Membrane transporter/Ion channel; Metabolism |
Gboxin 是一种氧化磷酸化抑制剂,可靶向抑制胶质母细胞瘤生长,还抑制 F0F1 ATP 合成,具有抗肿瘤活性。 | |||
T28167 |
NGB 2904
NGB2904 HCl,NGB-2904,NGB2904 |
Others; Dopamine Receptor; 5-HT Receptor | GPCR/G Protein; Neuroscience; Others |
NGB 2904 是一种具有口服活性的、选择性的多巴胺(DA) D3受体拮抗剂,可用于具可卡因成瘾。 | |||
T5335 |
S-Gboxin
|
Others | Others |
S-Gboxin 是 Gboxin 的功能类似物,能够抑制小鼠和人胶质母细胞瘤的生长(IC50:470 nM)。它具有抗肿瘤作用。 | |||
T22094 |
JGB1741
ILS-JGB-1741 |
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
JGB1741 (ILS-JGB-1741) 是一种有效的选择性 SIRT1 抑制剂,IC50 为 15 μM。 JGB1741 调节 Bax/Bcl2 比率、细胞色素 c 释放和 PARP 裂解并增加乙酰化 p53 水平,导致 p53 介导的细胞凋亡。 JGB1741可用于乳腺癌研究。 | |||
T2378 |
RGB-286638 free base
|
GSK-3; MEK; JAK; CDK | Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; JAK/STAT signaling; MAPK; PI3K/Akt/mTOR signaling; Stem Cells |
RGB-286638 free base 是一种新型 CDK 抑制剂,抑制cyclin T1-CDK9、cyclin B1-CDK1、cyclin E-CDK2、cyclin D1-CDK4、cyclin E-CDK3和p35-CDK5活性,IC50分别为 1、2、3、4、5 和 5 nM。它也抑制 GSK-3β、TAK1、Jak2 和 MEK1,IC50值分别为 3、5、50和 54 nM。 | |||
T19337 |
GBR 12783 dihydrochloride
GBR12783 2HCl |
Others | Others |
GBR 12783 dihydrochloride (GBR12783 2HCl) 是一种特异性,有效且选择性的多巴胺摄取抑制剂,可抑制大鼠和小鼠纹状体突触小体对 [3H] 多巴胺 ([3H]dopamine) 的摄取,IC50值分别为 1.8 nM 和 1.2 nM。GBR 12783 dihydrochloride 还可改善大鼠记忆力并增加海马通路乙酰胆碱的释放。 | |||
T16754 |
RIPGBM
|
Apoptosis | Apoptosis |
RIPGBM 是一种选择性诱导多形性胶质母细胞瘤癌症的细胞凋亡诱导剂 ,EC50≤500 nM。 | |||
T10531 |
BGB-102
JNJ-26483327 |
EGFR; VEGFR; FLT; Src | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
BGB-102 (JNJ-26483327) 是一种针对FLT3 和 YES1 的激酶抑制剂和 针对 EGFR 和 VEGFR3 的拮抗剂,可用于研究黄斑变性和与遗传病与畸形相关的疾病。 | |||
T78056 |
HMGB1-IN-1
|
||
HMGB1-IN-1(化合物6)在RAW264.7细胞中具有显著的NO抑制活性,其IC50为15.9 ± 0.6 μM。该化合物能够抑制HMGB1/NF-κB/NLRP3信号通路,并且在肾损伤模型中展现出优异的抗炎及抗脓毒症效果。 | |||
T79139 |
GBD-9
|
PROTACs | PROTAC |
GBD-9,一种双机制降解剂,有效通过E3 连接酶cereblon(CRBN)招募来降解BTK与GSPT1。作为PROTAC分子,GBD-9诱导BTK降解,同时亦作为分子胶(molecular glue)针对GSPT1。该化合物能有效抑制癌细胞生长。 | |||
T71227 | LGB-321 HCl | ||
LGB-321 is a potent and selective ATP-competitive small molecule inhibitor of PIM kinases (Pan-PIM kinase inhibitor). LGB321 is unique relative to previously described PIM inhibitors, in that it is active in PIM2 dependent cell lines. , a kinase that has proven difficult to inhibit in the cellular context. Consistent with its activity on all three PIM kinases, LGB321 inhibits proliferation of a number of cell lines derived from diverse hematological malignancies, including MM, AML, CML and B-Cel... | |||
T81285 | RGB-1 | ||
RGB-1为多环芳烃类化合物,作为RNA G-四链体 (RNA G-quadruplexes) 的稳定剂,能够抑制RNA翻译,并在乳腺癌细胞中下调NRAS原癌基因的表达。 | |||
T23786 |
BGB659
BGB 659,BGB-659 |
||
BGB659 is effective inhibitor of RAF. | |||
T68727 |
GBR-13119
|
||
GBR-13119 is a dopamine uptake inhibitor. | |||
T11371 |
GBR 12783
|
Others | Others |
GBR 12783 can improve memory performance and increase hippocampal acetylcholine release in rats. GBR 12783 is a specific, potent and selective dopamine uptake inhibitor that inhibits the [3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively. | |||
T1871L |
GBR 12935
GBR-12935 free base,GBR12935,GBR-12935 |
||
GBR-12935 is a piperazine derivative. It is an effective and selective dopamine reuptake inhibitor. GBR-12935 is now widely used in animal research into Parkinson's disease and the dopamine pathways in the brain. | |||
T68709 |
GBR-13098 dimethanesulfonate
|
||
GBR-13098 dimethanesulfonate is an inhibitor of dopamine uptake. | |||
T31917 |
GBR-12879
GBR 12879,J389.022H,GBR12879 |
||
GBR-12879 is a bioactive chemical. | |||
T30809 |
C-Gboxin
C Gboxin |
||
C-Gboxin is a functional Gboxin analogue that is suitable for live-cell ultraviolet crosslink conjugation and click chemistry. | |||
T71501 | GBS-149 | ||
GBS-149 is a novel non-toxic and mammalian-specific LINE-1 inhibitor. | |||
T41074 |
MB-VC-MGBA
|
||
MB-VC-MGBA is a potent antitumor drug-linker conjugate for antibody-drug conjugates (ADC), utilizing the minor-groove-binding DNA-alkylating agent (MGBA), connected through the ADC linker MB-VC. | |||
T70025 |
NGB-2849
|
||
NGB-2849 is a selective dopamine D3 receptor antagonist. | |||
T78075 |
GBT1118
|
Others | Others |
GBT1118是一种有效的口服血红蛋白氧亲和力变构调节剂,可增强对严重缺氧的耐受性。 | |||
T68710 |
GBR-13069 dimethanesulfonate
|
||
GBR-13069 dimethanesulfonate is a dopamine reuptake inhibitor. | |||
T70914 |
GBR-12935 maleate
|
||
GBR-12935 is a potent and selective dopamine reuptake inhibitor. It was originally developed in its 3H radiolabelled form for the purpose of mapping the distribution of dopaminergic neurons in the brain by selective labelling of dopamine transporter proteins. This has led to potential clinical uses in the diagnosis of Parkinson's disease, although selective radioligands such as Ioflupane (¹²³I) are now available for this application. GBR-12935 is now widely used in animal research into Parkin... | |||
T28532 |
RGB-286147
|
||
RGB-286147 is a potent, selective, ATP-competitive Cdks inhibitor. | |||
T22799 |
GBR 13069 dihydrochloride
|
Others | Others |
GBR 13069 dihydrochloride is a dopamine uptake inhibitor. | |||
T72658 | cRIPGBM chloride | ||
cRIPGBM chloride是一种口服有效的促凋亡衍生物,针对多形性胶质母细胞瘤(GBM)中的癌症干细胞(CSC)。该化合物通过靶向受体相互作用蛋白激酶2(RIPK2),诱导caspase 1依赖的细胞凋亡,抑制RIPK2/TAK1的活性,增加RIPK2/caspase 1复合物的形成,表现出强大的体内抗肿瘤效果。 | |||
T82189 |
HMGB1-IN-2
|
||
HMGB1-IN-2 (compound 15) 是一种针对高度保守的核蛋白 HMGB1 的抑制剂,其在 RAW264.7 细胞中展现出 NO 抑制活性,IC50 为 20.2 μM。 HMGB1-IN-2 (30 μM) 能够减少 IL-1β、TNF-α、caspase-1 p20 的表达,并抑制 NF-κB p65 的磷酸化作用,显示出抗凋亡特性。在脓毒症急性肾损伤模型的小鼠中,HMGB1-IN-2(15 mg/kg;腹腔注射)可有效减轻肾脏伤害。此外,HMGB1-IN-2 对 Huh7 细胞和 A549 细胞的 IC50 分别为 77.0 μM 和 82.0 μM。 | |||
T33034 |
Lyngbyatoxin B
|
||
Lyngbyatoxin B is an irritant form Lyngbya majuscula. | |||
T73196 |
RGB-286638
|
||
RGB-286638 是一种有效的 CDK 抑制剂,抑制cyclin T1-CDK9,cyclin B1-CDK1,cyclin E-CDK2,cyclin D1-CDK4,cyclin E-CDK3和p35-CDK5活性,IC50分别为 1,2,3,4,5 和 5 nM;同时可抑制GSK-3β,TAK1,Jak2和MEK1,IC50值分别为 3,5,50,和 54 nM。 | |||
T73381 | BGB-8035 | ||
BGB-8035 是一种口服有效,高选择性BTK 抑制剂,对 BTK、TEC、EGFR 的IC50分别为 1.1 nM、99 nM、621 nM。BGB-8035 具有抗肿瘤和抗关节炎活性。BGB-8035 具有用于 B 细胞恶性肿瘤和自身免疫性疾病研究的潜力。 | |||
T23065 |
NGB 2904 hydrochloride
NGB 2904 |
Others | Others |
dopamine D3 receptor antagonist | |||
T19250 |
cRIPGBM
|
TNF | Apoptosis |
cRIPGBM 是RIPGBM 的促凋亡衍生物。cRIPGBM 通过与受体相互作用蛋白激酶2(RIPK2)结合,从而选择性诱导 GBM 肿瘤干细胞凋亡,对 GBM-1 细胞的EC50值为 68 nM。 | |||
T34663 |
S-MGB-234 TFA
SMGB-234,SMGB 234,S-MGB-234,S-MGB234,SMGB234,S-MGB 234 |
||
S-MGB-234 is a novel Minor Groove Binder that cures animal African trypanosomiasis in an in vivo mouse model. S-MGB-234 has significant potential as novel therapeutic agents for animal African trypanosomiasis. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0783 |
Mianserin hydrochloride
Mianserin HCl,Org GB 94,盐酸米安色林,ORG GB-94 HCl |
Dopamine Receptor; 5-HT Receptor; Opioid Receptor; Adrenergic Receptor; Histamine Receptor | Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Mianserin hydrochloride (Org GB 94) 是一种有抗抑郁活性的 H1 受体反向激动剂。 | |||
TN5477 |
GB-2a
|
||
GB 2a shows antioxidant and anti-inflammatory effects, it can prevent the carrageenan-induced paw oedema. GB 2a biflavonoid can promote inhibition on tyrosinase activity and reduced melanin biosynthesis in B16F10 cells, which suggests great potential for | |||
TN4118 |
GB 1b
|
Others | Others |
GB 1b 是一种从藤黄 Garcinia travancorica 叶中分离出来的天然产物。 | |||
TN4117 | GB 1a | Antioxidant; Tyrosinase | oxidation-reduction; Proteases/Proteasome |
GB 1a 是一种从藤黄 Garcinia travancorica 叶中分离出来的天然产物。 | |||
T33033 |
Lyngbyatoxin A
|
||
Lyngbyatoxin A is an indole alkaloid from blue-green alga Lyngbya majuscula Gomont; responsible for dermatitis known as "swimmers' itch" in Hawaii. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-00811 |
Human cytomegalovirus (HCMV) Glycoprotein B/gB Protein
Human cytωlovirus (HCMV) Glycoprotein B/gB |
CMV | HEK293 Cells |
Human cytomegalovirus (HCMV) Glycoprotein B/gB Protein is expressed in HEK293 mammalian cells. The predicted molecular weight is 92 kDa and the accession number is P13201. | |||
TMPY-01201 |
Human cytomegalovirus (HCMV) Glycoprotein B/gB Protein (His)
Human cytωlovirus (HCMV) Glycoprotein B/gB |
CMV | HEK293 Cells |
Human cytomegalovirus (HCMV) Glycoprotein B/gB Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 93.2 kDa and the accession number is P13201. | |||
TMPY-02105 |
SCF Protein, Mouse, Recombinant (His)
Gb,Kitlg,SF,Clo,Mgf,SLF,Sl,KIT ligand,SCF,Con |
Mouse | Baculovirus Insect Cells |
SCF Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 19.7 kDa and the accession number is P20826-1. | |||
TMPY-00054 |
Macaca fascicularis Cytomegalovirus (CyCMV) (strain OT-1) glycoprotein B/gB Protein (hFc)
Macaca fascicularis Cytωlovirus (CyCMV) (strain OT-1) glycop... |
CyCMV | HEK293 Cells |
Macaca fascicularis Cytomegalovirus (CyCMV) (strain OT-1) glycoprotein B/gB Protein (hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 102.5 kDa and the accession number is E7DB34. | |||
TMPY-00810 |
Human cytomegalovirus (HCMV) Glycoprotein B/gB Protein (hFc)
Human cytωlovirus (HCMV) Glycoprotein B/gB |
CMV | HEK293 Cells |
Human cytomegalovirus (HCMV) Glycoprotein B/gB Protein (hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 118 kDa and the accession number is P13201. | |||
TMPY-00812 |
Human cytomegalovirus (HCMV) Glycoprotein B/gB Protein (aa 1-700, hFc)
Human cytωlovirus (HCMV) Glycoprotein B/gB |
CMV | HEK293 Cells |
Human cytomegalovirus (HCMV) Glycoprotein B/gB Protein (aa 1-700, hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 104 kDa and the accession number is P13201. | |||
TMPY-05135 |
SCF Protein, Mouse, Recombinant (His), Biotinylated
Con,SLF,SF,Mgf,Gb,Clo,KIT ligand,Sl,Kitlg,SCF |
Mouse | Baculovirus Insect Cells |
SCF Protein, Mouse, Recombinant (His), Biotinylated is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 19.7 kDa and the accession number is P20826-1. | |||
TMPY-06816 |
HSV 2 (strain 333) Glycoprotein B/gB Protein (His)
|
HSV2 | Baculovirus Insect Cells |
HSV 2 (strain 333) Glycoprotein B/gB Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 73.88 kDa and the accession number is P06763. | |||
TMPY-06855 |
Varicella-zoster virus (VZV) (strain Oka vaccine) Glycoprotein B/gB Protein
|
VZV | CHO Cells |
Varicella-zoster virus (VZV) is a highly fusogenic virus, but the degree of fusion is dependent on the cell substrate in which the virus is propagated. Varicella-zoster virus (VZV) is classified as an alphaherpesvirus based on its growth characteristics and its ability to become latent in the nervous system of the host. Like all known herpesviruses, VZV encodes a homolog of glycoprotein B (gB). Glycoprotein B (gB) is the most conserved entry glycoprotein among herpesviruses with an amino acid se... | |||
TMPH-03610 |
Suid herpesvirus 1 (SuHV-1) Glycoprotein B/gB Protein (His)
|
SuHV-1 | E. coli |
Suid herpesvirus 1 (SuHV-1) Glycoprotein B/gB Protein (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 11.8 kDa and the accession number is P08355. | |||
TMPH-03406 |
Rhesus cytomegalovirus (RhCMV) (strain 68-1) Glycoprotein B/gB Protein (His & Myc)
|
RhCMV | E. coli |
Rhesus cytomegalovirus (RhCMV) (strain 68-1) Glycoprotein B/gB Protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 18.0 kDa and the accession number is P89053. | |||
TMPH-02086 |
SRSF3 Protein, Human, Recombinant (GB1 & His)
|
Human | E. coli |
SRSF3 Protein, Human, Recombinant (GB1 & His) is expressed in E. coli. | |||
TMPY-01848 |
HMGB1 Protein, Human, Recombinant (aa 1-215, His)
SBP-1,high mobility group box 1,HMG-1,HMG3,HMG1 |
Human | HEK293 Cells |
HMGB1 Protein, Human, Recombinant (aa 1-215, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.3 kDa and the accession number is A0A024RDR0. | |||
TMPY-00476 |
ITGB1 Protein, Human, Recombinant (His)
VLAB,integrin, beta 1 (fibronectin receptor, beta polypeptid... |
Human | HEK293 Cells |
ITGB1 (Integrin Subunit Beta 1) is a Protein Coding gene. This gene encodes a beta subunit, which is a type 1 transmembrane protein of the integrin beta chain family. ITGB1 is a heterodimeric cell-surface receptor involved in cell functions such as proliferation, migration, invasion, and survival. ITGB1 has been recognized to play a major role in tumor growth, invasion, and metastasis. Using luciferase assays, the researcher identified ITGB1 as a direct target of miR-134. ITGB1 is a direct targe... | |||
TMPY-02590 |
HMGB1 Protein, Mouse, Recombinant (hFc)
HMG-1,SBP-1,high mobility group box 1,p30,Hmg1,DEF,amphoteri... |
Mouse | HEK293 Cells |
HMGB1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 53.3 kDa and the accession number is P63158. | |||
TMPH-01537 |
ITGB7 Protein, Human, Recombinant (His)
|
Human | E. coli |
ITGB7 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 82.5 kDa and the accession number is P26010. | |||
TMPH-02771 |
GBA Protein, Mouse, Recombinant (His & SUMO)
|
Mouse | E. coli |
GBA Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPK-00839 |
ITGB6 Protein, Human, Recombinant (His)
β6,Integrin β-6,β 6,beta 6,Integrin β 6,Integrin beta-6,Inte... |
Human | HEK293 Cells |
ITGB6 is known to be one of the major receptor components involved in host tropism of foot-and-mouth disease (FMD) virus in cattle. A competitive PCR technique called ARMS PCR was adapted to identify a single-nucleotide polymorphism (SNP), G29A, db SNP Id: rs109075046, in the 5' untranslated region (5'UTR) of the bovine ITGB6 gene. ITGB6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 75.4 kDa and the accession number is ... | |||
TMPH-01637 |
Mammaglobin-A/SCGB2A2 Protein, Human, Recombinant (GST)
|
Human | E. coli |
Mammaglobin-A/SCGB2A2 Protein, Human, Recombinant (GST) is expressed in E. coli. | |||
TMPY-02549 |
GBP1 Protein, Human, Recombinant (His)
guanylate binding protein 1,GBP1 |
Human | HEK293 Cells |
Guanylate-binding protein 1 (GBP-1) is a member of the GBP family whose members are GTPases induced in response to interferon-λ (IFN-λ), with seven highly homologous members in humans, termed HuGBP-1 to HuGBP-7. GBP-1 expression is induced by type1 and type2 interferons, including IFN-λ and also by interleukin-1β (IL-1β), IL-1α, and tumor necrosis factor-α (TNF-α). GBP-1 is key to the protective immunity against microbial and viral pathogens. GBP-1 was only secreted from endothelial cells. Secre... | |||
TMPY-01579 |
GBA3 Protein, Human, Recombinant (His)
glucosidase, beta, acid 3 (gene/pseudogene),GBA3,MG... |
Human | Baculovirus Insect Cells |
Cytosolic beta-glucosidase, also known as Cytosolic beta-glucosidase-like protein 1, GBA3, CBG and CBGL1 is a cytoplasm protein which belongs to theglycosyl hydrolase 1 family and Klotho subfamily. GBA3 / CBGL1 is a glycosidase probably involved in the intestinal absorption and metabolism of dietary flavonoid glycosides. GBA3 / CBGL1 is present in small intestine (at protein level). GBA3 / CBGL1 is expressed in liver, small intestine, colon, spleen and kidney. GBA3 / CBGL1 is down-regulated in r... | |||
TMPY-04102 |
SCGB3A1 Protein, Human, Recombinant (mFc)
PnSP-2,secretoglobin, family 3A, member 1,LU105,UGRP2,HIN1,H... |
Human | HEK293 Cells |
SCGB3A1 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 34.6 kDa and the accession number is Q96QR1. | |||
TMPY-03427 |
HMGB1 Protein, Human, Recombinant (aa 57-158, His)
SBP-1,HMG3,high mobility group box 1,HMG1,HMG-1 |
Human | E. coli |
HMGB1 Protein, Human, Recombinant (aa 57-158, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 13.6 kDa and the accession number is P09429. | |||
TMPH-01538 |
ITGBL1 Protein, Human, Recombinant (His & Myc)
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Human | E. coli |
ITGBL1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli. | |||
TMPJ-00049 |
CGB Protein, Human, Recombinant (His)
Chorionic gonadotrophin chain β,CG-β,Chorionic gonadotrophin... |
Human | HEK293 Cells |
Choriogonadotropin subunit beta is also known as CG-beta, Chorionic gonadotrophin chain beta. It is a protein that in humans is encoded by the CGB gene. It belongs to the glycoprotein hormones subunit beta family. Choriogonadotropin subunit beta can stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. | |||
TMPH-03554 |
HlgB Protein, S. aureus, Recombinant (E. coli, His)
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Staphylococcus aureus | E. coli |
Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity. HlgB Protein, S. aureus, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 38.1 kDa and the accession number is P0A075. | |||
TMPJ-00786 |
ITGB1 Protein, Human, Recombinant (aa 21-728, His)
Integrin Beta-1,VLA-4 Subunit β,Fibronectin Receptor Subunit... |
Human | HEK293 Cells |
Integrin β-1 (ITGB1) belongs to the integrin β chain family. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. ITGB1 is an integrin unit associated with very late antigen receptors, which contains one VWFA domain. It is known to conjoin with α-3 subunit to create α3β1 complex that reacts to such molecules as netrin-1 and ree... | |||
TMPJ-00918 |
HMGB2 Protein, Human, Recombinant (His)
High Mobility Group Protein B2,HMG2,High Mobility Group Prot... |
Human | HEK293 Cells |
High Mobility Group Protein B2 (HMGB2) belongs to the non-histone chromosomal high-mobility group protein family. Members of this family are chromatin-associated and widely spread in the nucleus of higher eukaryotic cells. HMGB2 contains 2 HMG box DNA-binding domains. It is associated with chromatin and has the ability to bend DNA, preferentially single-stranded DNA. It is shown that HMGB2 is able to efficiently bend DNA and form DNA circles. In addition, HMGB2 is involved in the final ligation ... | |||
TMPH-03342 |
GBA2 Protein, Rat, Recombinant (His)
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Rat | E. coli |
GBA2 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 42.6 kDa and the accession number is Q5M868. | |||
TMPH-01624 |
GBA Protein, Human, Recombinant
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Human | E. coli |
Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction tha... | |||
TMPY-00025 |
Mammaglobin B/SCGB2A1 Protein, Human, Recombinant (hFc)
UGB3,MGB2,LPNC,LPHC,LIPHC,secretoglobin fa... |
Human | HEK293 Cells |
SCGB2A1 represented a novel, prognostic factor for CRC, and that expression of SCGB2A1 correlated with chemoresistance, radioresistance and cancer cell stemness. SCGB2A1 is a top differentially expressed gene in all major histological types of ovarian cancers and may represent a novel and attractive target for the immunotherapy of patients harbouring recurrent disease resistant to chemotherapy. | |||
TMPY-03122 |
GBP2 Protein, Human, Recombinant (His)
guanylate binding protein 2,GBP2 |
Human | HEK293 Cells |
GBP-2 belongs to the guanylate-binding protein (GBP) family. GBPs are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP). As GTPases induced by IFN-gamma (Interferon-inducible GTPase), they are key to the protective immunity against microbial and viral pathogens. GBP-2 is a GTPase that converts GTP to GDP and GMP. It binds GTP, GDP and GMP. GBP-2 hydrolyzes GTP very efficiently. GDP rather than GMP is the major reaction product. GBP-2 is induced by interf... | |||
TMPH-01623 |
GBA Protein, Human, Recombinant (His & Myc & SUMO)
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Human | E. coli |
Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction tha... | |||
TMPH-02891 |
SCGB3A2 Protein, Mouse, Recombinant (GST & His)
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Mouse | E. coli |
SCGB3A2 Protein, Mouse, Recombinant (GST & His) is expressed in E. coli expression system with N-6xHis-GST tag. The predicted molecular weight is 43.2 kDa and the accession number is Q920H1. | |||
TMPH-01403 |
PYGB Protein, Human, Recombinant (GST)
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Human | E. coli |
PYGB Protein, Human, Recombinant (GST) is expressed in E. coli. | |||
TMPH-01536 |
ITGB4 Protein, Human, Recombinant (His & Myc)
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Human | E. coli |
Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling. | |||
TMPH-02707 |
HMGB1 Protein, Mouse, Recombinant (His)
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Mouse | E. coli |
HMGB1 Protein, Mouse, Recombinant (His) is expressed in E. coli. | |||
TMPH-02890 |
SCGB1C1 Protein, Mouse, Recombinant (His & SUMO)
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Mouse | E. coli |
SCGB1C1 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPY-03982 |
CGB5 Protein, Human, Recombinant (His)
chorionic gonadotropin beta subunit 5,HCG,chorionic gonadotr... |
Human | HEK293 Cells |
The human CGB5 gene encodes chorionic gonadotropin (hCG)beta 5, which is aberrantly expressed in trophoblastic neoplasm and in some non-trophoblastic neoplasms. Fucntional studies observed that it involved tumor initiation, growth, and metastatic outgrowth. Carriage of particular variants in the promoter of the CGB5 gene seems to protect against RM. CGB5 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17 kDa and the accessi... | |||
TMPH-02397 |
MIP Protein, Legionella longbeachae, Recombinant (His & Myc)
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Legionella longbeachae | E. coli |
Essential virulence factor associated with macrophage infectivity. Exhibits PPIase activity. | |||
TMPJ-00668 |
HMGB3 Protein, Human, Recombinant (His)
HMG4,High Mobility Group Protein 2a,HMG-2a,High Mobility Gro... |
Human | HEK293 Cells |
High Mobility Group Protein B3 (HMGB3) belongs to the HMGB family. Members of the HMG box subfamily are thought to be have an important role in DNA replication, nucleosome assembly and transcription. HMGB3 binds preferentiallly single-stranded DNA and unwinds double stranded DNA. HMGB3 consists of 200 amino acids and is localized to the cell nucleus. It contains two HMG box DNA-binding domain. HMGB3 binds preferentially single-stranded DNA and unwinds double stranded DNA. | |||
TMPY-05099 |
GBA/glucocerebrosidase Protein, Human, Recombinant (His)
glucosidase, β, acid,GLUC,GCB,GBA1,glucosidase, bet... |
Human | HEK293 Cells |
Mutations in the GBA gene, encoding the lysosomal hydrolase glucocerebrosidase (GCase), are the most common known genetic risk factor for Parkinson's disease (PD) and dementia with Lewy bodies (DLB). ASAH1 (acid ceramidase 1) and GBA2 (glucocerebrosidase 2) enzymes that mediate glucosylsphingosine production and metabolism are attractive therapeutic targets for treating mutant GBA-associated PD. | |||
TMPH-02772 |
GBA Protein, Mouse, Recombinant (His)
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Mouse | P. pastoris (Yeast) |
GBA Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 57.5 kDa and the accession number is P17439. | |||
TMPY-00822 |
HMGB1 Protein, Human, Recombinant (hFc)
HMG1,SBP-1,high mobility group box 1,HMG3,HMG-1 |
Human | HEK293 Cells |
HMGB1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.5 kDa and the accession number is A0A024RDR0. | |||
TMPH-03555 |
HlgB Protein, S. aureus, Recombinant (His)
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Staphylococcus aureus | P. pastoris (Yeast) |
Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity. HlgB Protein, S. aureus, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 36.1 kDa and the accession number is P0A075. | |||
TMPH-03313 |
HMGB1 Protein, Rat, Recombinant (His)
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Rat | E. coli |
HMGB1 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 30.8 kDa and the accession number is P63159. | |||
TMPH-00829 |
Fibrinogen beta chain/FGB Protein, Horse, Recombinant
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Horse | E. coli |
Fibrinogen beta chain/FGB Protein, Horse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 53.2 kDa and the accession number is F6PH38. | |||
TMPY-01122 |
CGB5 Protein, Human, Recombinant (mFc)
HCG,hCGB,chorionic gonadotropin beta subunit 5,chor... |
Human | HEK293 Cells |
The human CGB5 gene encodes chorionic gonadotropin (hCG)beta 5, which is aberrantly expressed in trophoblastic neoplasm and in some non-trophoblastic neoplasms. Fucntional studies observed that it involved tumor initiation, growth, and metastatic outgrowth. Carriage of particular variants in the promoter of the CGB5 gene seems to protect against RM. CGB5 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 41.9 kDa and the acces... | |||
TMPK-01247 |
ITGB6 Protein, Mouse, Recombinant (His)
ITGB6,Integrin β-6,Integrin beta-6 |
Mouse | HEK293 Cells |
ITGB6 is known to be one of the major receptor components involved in host tropism of foot-and-mouth disease (FMD) virus in cattle. A competitive PCR technique called ARMS PCR was adapted to identify a single-nucleotide polymorphism (SNP), G29A, db SNP Id: rs109075046, in the 5' untranslated region (5'UTR) of the bovine ITGB6 gene. ITGB6 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 75.7 kDa and the accession number is ... | |||
TMPH-03206 |
ITGB8 Protein, Rabbit, Recombinant (His & Myc)
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Rabbit | E. coli |
Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligands. Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs). Required during vasculogenesis. ITGB8 Protein, Rabbit, Recombinant (His & Myc) is expressed in E. coli ... | |||
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