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Search Results for " caspase-8 "

Targets Recommended: Caspase

34

抑制剂 & 化合物

13

天然产物

20

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T7019	Z-IETD-FMK Z-IE(OMe)TD(OMe)-FMK,Caspase-8 Inhibitor	Caspase	Apoptosis; Proteases/Proteasome
	Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) 是一种选择性 caspase 8 抑制剂，具有细胞渗透性。它也是颗粒酶 B 抑制剂。
T10384	Farudodstat ASLAN003	Apoptosis; Dehydrogenase; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Farudodstat (ASLAN003) 是一种具有口服活性的二氢乳清酸脱氢酶 (DHODH) 抑制剂，对人 DHODH 酶的IC50为 35 nM。它通过激活 AP-1 转录因子来抑制蛋白质合成，可以诱导凋亡，并在急性髓样白血病异种移植小鼠中大大延长其生存期。
T2065	Bioymifi DR5 Activator	Apoptosis; TNF	Apoptosis
	Bioymifi (DR5 Activator) 是一种 TRAIL 受体DR5激活剂，与DR5的胞外结构域结合，Kd 为 1.2 μM，它可诱导 DR5 聚集，导致细胞凋亡。
T6761	Ossirene AS101	IL Receptor; Caspase; Interleukin	Apoptosis; Immunology/Inflammation; Proteases/Proteasome
	Ossirene (AS101) 是一种免疫调节抑制剂，是一种新型 IL-1beta 转化酶抑制剂，可用于自身免疫性疾病和某些恶性肿瘤。它通过抑制IL-10消除 STAT3 的磷酸化，有效抑制Caspase-1。
T76571	Caspase-8-IN-1
	Caspase-8-IN-1 是一种有效的caspase-8抑制剂。
T6005	Z-DEVD-FMK Caspase-3 Inhibitor	Caspase	Apoptosis; Proteases/Proteasome
	Z-DEVD-FMK (Caspase-3 Inhibitor) 是一种选择性、不可逆的 Caspase-3 抑制剂，IC50为 18 μM。它也抑制 caspase-6、caspase-7、caspase-8 和 caspase-10。
T30077	Anisperimus LF 150195,LF-150195,LF 15-0195,LF-15-0195,LF15-0195	Caspase	Apoptosis; Proteases/Proteasome
	Anisperimus (LF 15-0195) 是一种免疫抑制剂，通过促进 DISC 水平的 caspase-8 和 caspase-10 激活来增强激活诱导的 T 细胞死亡，通过促进表达 Foxp3 的调节性 CD4 T 细胞的发育来预防中枢神经系统自身免疫。
T10366L	Arg-Gly-Asp-Ser acetate Arg-Gly-Asp-Ser acetate(91037-65-9 free base)	Integrin	Cytoskeletal Signaling
	Arg-Gly-Asp-Ser acetate 是一种整合素结合序列，可直接特异性结合 pro-caspase-8、pro-caspase-9 和 pro-caspase-3，但不结合 pro-caspase-1。它抑制整合素受体功能。
T36333	Z-IETD-AFC
	Z-IETD-AFC 是 caspase-8 和颗粒酶 B 的荧光底物，可用于定量半胱天冬酶-8 或颗粒酶 B 的活性。
T36343	Ac-LETD-AFC
	Ac-LETD-AFC 是一种可被 caspase-8 特异性裂解的荧光底物,可通过荧光检测游离 AFC来量化 Caspase 活性。Ac-LETD-AFC 激发波长为 400 纳米，发射波长为 505 纳米。
T39308	Boc-Asp(OMe)-fluoromethyl ketone Boc-Asp(OMe)-fluoromethyl ketone,Boc-Asp(OMe)-FMK	Caspase	Apoptosis; Proteases/Proteasome
	Boc-Asp(OMe)-fluoromethyl ketone (Boc-Asp(OMe)-FMK) 是广谱的 caspase 抑制剂，可抑制 Fas 介导的吞噬作用和氧化破裂抑制，但对 IL-8 的趋化活性无影响。
T9083	TC11 CLT-003,1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11	BCL; Caspase; CDK	Apoptosis; Cell Cycle/Checkpoint; Proteases/Proteasome
	TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) 是一种有效的肿瘤细胞增殖抑制剂，并通过激活 caspase-3、8 和 9 诱导细胞凋亡。在长时间有丝分裂阻滞期间，它诱导 MCL1降解导致凋亡。它作为苯酞酰亚胺衍生物在结构上与免疫调节药物相关。
TQ0146	Ac-DEVD-CHO	Apoptosis; Caspase	Apoptosis; Proteases/Proteasome
	Ac-DEVD-CHO 是一种特异性 Caspase-3 抑制剂(Ki: 230 pM)。Ac-DEVD-CHO在 SLNT 诱导的细胞凋亡中有抑制作用。
T0282	Q-VD-OPH Quinoline-Val-Asp-Difluorophenoxymethylketone	Caspase; HIV Protease	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Q-VD-OPH (Quinoline-Val-Asp-Difluorophenoxymethylketone) 是一种具有强效抗凋亡特性的泛半胱天冬酶抑制剂。它可抑制 HIV 感染，能透过血脑屏障。
T80093	IETD-CHO TFA	Caspase	Apoptosis; Proteases/Proteasome
	IETD-CHO TFA (Caspase-8-IN-1) 是一种高效的 caspase-8 抑制剂。
T23859	CaspPro C-2,C 2,Casp-Pro,Casp Pro,C2
	CaspPro is a selective activator of caspase 8 that acts by potentiating TRAIL-induced cell death.
T21293	MX1013 MX 1013,MX-1013
	MX1013, a dipeptide pan-caspase inhibitor, inhibits caspase-1, -3, -6, -7, -8, and -9.
T83181	Ac-IETD-AMC
	Ac-IETD-AMC为乙酰基（Ac）修饰的荧光caspase-8/颗粒酶B底物，常用于检测caspase-8活性。
T72435	Z-LE(OMe)TD(OMe)-FMK
	Z-LE(OMe)TD(OMe)-FMK 是一种选择性的 caspase-8抑制剂，可以抑制细胞凋亡。
T73870	Arg-Gly-Asp-Ser TFA
	Arg-Gly-Asp-Ser (TFA) 为整联蛋白结合序列，专门抑制整联蛋白受体(integrin receptor)功能。它能够直接且特异性地与pro-caspase-8、pro-caspase-9和pro-caspase-3结合，而不与pro-caspase-1发生作用。
T80467	Boc-AEVD-CHO	Caspase	Apoptosis; Proteases/Proteasome
	Boc-AEVD-CHO是一种Caspase 8抑制剂，适用于细胞凋亡以及免疫和炎症疾病研究。
T39672	Ac-Ile-Glu-Thr-Asp-pNA
	Ac-Ile-Glu-Thr-Asp-pNA is a caspase-8 substrate that undergoes enzymatic binding and cleavage specifically at the Ile-Glu-Thr-Asp (IETD) peptide sequence. This cleavage results in the release of p-nitroalinide, which can be quantitatively measured using colorimetric detection at 405 nm. This measure serves as an indicator of caspase-8 enzyme activity.
T78586L	Ac-IETD-CHO TFA Ac-IETD-CHO TFA（191338-86-0 Free base )	Apoptosis; Caspase	Apoptosis; Proteases/Proteasome
	Ac-IETD-CHO TFA 是一种 granzyme B 和 caspase-8 抑制剂，通过阻断 caspase3 前体裂解抑制 caspase8 活性。Ac-IETD-CHO TFA 抑制 Fas 介导的细胞凋亡(Apoptosis)。
T41189	AY 254
	AY 254 is a potent PAR2 biased agonist. Selectively activates ERK1/2 signaling (EC50= 2 nM for ERK1/2 phosphorylation versus 80 nM for Ca2+release). Reduces cytoKi ne-induced caspase 3/8 activation, promotes scratch-wound healing, and induces IL-8 secretion, in human colorectal cancer (HT29) cellsin vitro.
T19906	5'-O-Tritylthymidine M-13,M13,M 13,Monotritylthymidine
	5'-O-Tritylthymidine is a blocker of the formation of the FAK/Mdm-2 complex. 5'-O-Tritylthymidine activates p53 and caspase-8. It also leads to increase detachment and apoptosis in breast and colon cancers.
T78586	Ac-IETD-CHO	Apoptosis	Apoptosis
	Ac-IETD-CHO是一种针对granzyme B和caspase 8的有效可逆抑制剂，能够阻止Fas介导的(Apoptosis)、出血和肝衰竭，并且能够抑制细胞毒性T淋巴细胞引发的细胞死亡。
T76300	Edratide
	Edratide (TV 4710)是一种基于人类抗DNA抗体的互补决定区1(CDR1)、表达主要独特型16/6 Id的19个氨基酸组成的合成肽。该合成肽能降低细胞凋亡(apoptosis) (Apoptosis)率，调节caspase-8和caspase-3的活性，并上调Bcl-xL，显示出对系统性红斑狼疮(SLE)的研究潜力。
T35729	Nemadipine-A
	Nemadipine A is an L-type calcium channel blocker that induces morphological and growth defects in wild-type C. elegans and those with hypoexpression of egl-19, which encodes the only L-type calcium channel α1-subunit in the C. elegans genome. It also inhibits L-type calcium channels in chick ciliary neurons. Nemadipine A increases TRAIL-induced cytotoxicity and synergistically enhances caspase-8 and caspase-3 activation in a concentration-dependent manner in H1299 lung adenocarcinoma cells. It ...
T76393	Amyloid 17-42
	Amyloid 17-42 (Aβ(17-42))，作为阿尔茨海默病中弥漫性斑块与唐氏综合症小脑前区的主要淀粉样蛋白成分，源于淀粉样蛋白前体蛋白(APP)经α与γ分泌酶的裂解作用。此外，Amyloid 17-42能通过Fas样/caspase-8途径促使神经细胞发生凋亡。
T37417L	Z-LLE-AMC acetate(348086-66-8 Free base)
	Z-LLE-AMC acetate(348086-66-8 Free base) 是 26S 蛋白酶体或 20S 蛋白水解核心的半胱天冬酶样谷氨酸后肽水解酶的荧光底物。 Z-LLE-AMC acetate 通常用于实验处理后的细胞裂解液中。
T69200	CGP74514A
	CGP74514A is a CDK1 inhibitor with potential anticancer activity. In U937 cells, CGP74514A - induced apoptosis (5 microM) became apparent within 4 hr and approached 100% by 24 hr. The pan- caspase inhibitor Boc-fmk and the caspase-8 inhibitor lETD-fmk opposed CGP74514A -induced caspase-9 activation and PARP degradation, but not cytochrome c or Smac/DIABLO release. CGP74514A -mediated apoptosis was substantially blocked by ectopic expression of full-length Bel- 2, a loop-deleted mutant Bcl-2, and...
T72475	Anticancer agent 58
	Anticancer agent 58 对多种癌细胞具有抑制活性，特别是在 A549 和 T24 细胞中，IC50分别为 0.6 μM 和 0.7 μM。Anticancer agent 58 通过激活 caspase3/8/9活性诱导细胞凋亡 (apoptosis)，也诱导 Ca2+和 ROS 水平升高。Anticancer agent 58 在 T24 异种移植小鼠模型中能显著抑制肿瘤生长。
T78855	Anticancer agent 157	NO Synthase	Immunology/Inflammation
	Anticanceragent 157（compound 15）是一种NO抑制剂，具有抗炎和抗癌特性，IC50值为0.62 μg/mL。它能够与iNOS和caspase 8结合，进而导致核断裂和染色质浓缩，从而诱导细胞凋亡。此外，Anticanceragent 157在不同癌细胞系中展现出显著的抑制活性，对HT29结肠癌细胞的IC50为2.45 μg/mL，对Hep-G2肝癌细胞的IC50为3.25 μg/mL，以及对B16-F10鼠黑色素瘤细胞的IC50为3.84 μg/mL。
T11864	Iptacopan LNP023	Others	Others
	Iptacopan (LNP023) 是一种与factor B 亲和力较高的抑制剂。

化合物

Cat.No: T7019

Synonym: Z-IE(OMe)TD(OMe)-FMK,Caspase-8 Inhibitor

Target: Caspase

Cat.No: T10384

Synonym: ASLAN003

Target: Apoptosis, Dehydrogenase, DNA/RNA Synthesis

Cat.No: T2065

Synonym: DR5 Activator

Target: Apoptosis, TNF

Cat.No: T6761

Synonym: AS101

Target: IL Receptor, Caspase, Interleukin

Caspase-8-IN-1

Cat.No: T76571

Cat.No: T6005

Synonym: Caspase-3 Inhibitor

Target: Caspase

Cat.No: T30077

Synonym: LF 150195,LF-150195,LF 15-0195,LF-15-0195,LF15-0195

Target: Caspase

Arg-Gly-Asp-Ser acetate

Cat.No: T10366L

Synonym: Arg-Gly-Asp-Ser acetate(91037-65-9 free base)

Target: Integrin

Cat.No: T36333

Cat.No: T36343

Boc-Asp(OMe)-fluoromethyl ketone

Cat.No: T39308

Synonym: Boc-Asp(OMe)-fluoromethyl ketone,Boc-Asp(OMe)-FMK

Target: Caspase

Cat.No: T9083

Synonym: CLT-003,1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11

Target: BCL, Caspase, CDK

Cat.No: TQ0146

Target: Apoptosis, Caspase

Cat.No: T0282

Synonym: Quinoline-Val-Asp-Difluorophenoxymethylketone

Target: Caspase, HIV Protease

Cat.No: T80093

Target: Caspase

Cat.No: T23859

Synonym: C-2,C 2,Casp-Pro,Casp Pro,C2

Cat.No: T21293

Synonym: MX 1013,MX-1013

Cat.No: T83181

Z-LE(OMe)TD(OMe)-FMK

Cat.No: T72435

Arg-Gly-Asp-Ser TFA

Cat.No: T73870

Cat.No: T80467

Target: Caspase

Ac-Ile-Glu-Thr-Asp-pNA

Cat.No: T39672

Ac-IETD-CHO TFA

Cat.No: T78586L

Synonym: Ac-IETD-CHO TFA（191338-86-0 Free base )

Target: Apoptosis, Caspase

Cat.No: T41189

5'-O-Tritylthymidine

Cat.No: T19906

Synonym: M-13,M13,M 13,Monotritylthymidine

Cat.No: T78586

Target: Apoptosis

Cat.No: T76300

Cat.No: T35729

Cat.No: T76393

Z-LLE-AMC acetate(348086-66-8 Free base)

Cat.No: T37417L

Cat.No: T69200

Anticancer agent 58

Cat.No: T72475

Anticancer agent 157

Cat.No: T78855

Target: NO Synthase

Cat.No: T11864

Synonym: LNP023

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN2215	Taurochenodeoxycholic acid sodium 牛磺鹅去氧胆酸钠盐,Sodium taurochenodeoxycholate,牛磺鹅去氧胆酸钠	Apoptosis; Endogenous Metabolite	Apoptosis; Metabolism
	Taurochenodeoxycholic acid sodium (Sodium taurochenodeoxycholate) 是动物胆汁酸的主要生物活性物质之一。它可诱导细胞凋亡，具有抗炎和免疫调节作用。
T2163	Dihydrocapsaicin CCRIS1589,二氢辣椒素,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide	Others; TRP/TRPV Channel	Membrane transporter/Ion channel; Others
	Dihydrocapsaicin (CCRIS1589) 是一种天然来源的辣椒素，是TRPV1的选择性激动剂，同时可以增加 p-Akt 水平。它可以增强低温诱导的神经保护。
T9503	PHYTOSPHINGOSINE	Apoptosis	Apoptosis
	Phytosphingosine 是具有抗癌作用的一种磷脂。在癌细胞中，它通过 caspase 8 的激活和 Bax 转位诱导细胞凋亡。
T13815	Penicillic acid	Apoptosis; Caspase; Antibacterial; Antibiotic	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Penicillic acid，一种由多种Aspergillus和Penicillium物种合成的polyketide mycotoxin，通过阻碍caspase-8的自我处理作用，抑制Fas ligand引发的apoptosis。此外，体外研究表明，Penicillic acid在rat alveolar macrophages中显示出cytotoxic特性。
T2959	Ginsenoside Rh2 20(S)-Rh2,20S-Ginsenoside Rh2,人参皂苷Rh2,20(S)-Ginsenoside Rh2,人参皂苷 Rh2	Apoptosis; EGFR; Caspase; Endogenous Metabolite	Angiogenesis; Apoptosis; JAK/STAT signaling; Metabolism; Proteases/Proteasome; Tyrosine Kinase/Adaptors
	Ginsenoside Rh2 (20(S)-Ginsenoside Rh2) 诱导caspase-8和caspase-9活化。它以多途径方式诱导癌细胞凋亡。
T3240	Citronellol dihydrogeraniol,香茅醇,β-香茅醇,(±)-β-Citronellol	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Citronellol ((±)-β-Citronellol) 是一种单萜类化合物，从头状天竺葵中分离到。它可通过上调 TNF-α，RIP1/RIP3 的活性，下调 caspase-3/caspase-8 的活性，以及增加活性氧 (ROS) 的聚集来诱导肿瘤细胞的坏死性凋亡。
T5S1632	Barlerin 8-O-乙酰山栀苷甲酯,8-O-Acetylshanzhiside methyl ester,ND01	VEGFR; TNF; NF-κB; Akt; Caspase	Angiogenesis; Apoptosis; Cytoskeletal Signaling; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Tyrosine Kinase/Adaptors
	Barlerin (8-O-Acetylshanzhiside methyl ester) 是一种环孢菌素葡萄糖苷，从中国西藏民间药用植物中分离得到，能够抑制NF-κB 活性。
T10990	Dehydrocorydaline chloride 盐酸脱氢紫堇碱,13-Methylpalmatine chloride	BCL; PARP; p38 MAPK; Caspase; Parasite; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Proteases/Proteasome
	Dehydrocorydaline chloride (13-Methylpalmatine chloride) 是生物碱。Dehydrocorydaline 调节 Bax，Bcl-2蛋白表达；激活 caspase-7，caspase-8，并使 PARP 失活。它能增强 p38 MAPK 活化，具有抗炎、抗癌等功效。它具有强大的抗疟疾作用，并具低细胞毒性。
T2S2362	Dehydrocorydaline nitrate 去氢延胡索甲素硝酸盐,硝酸脱氢紫堇碱	BCL; Others; PARP; p38 MAPK; Caspase; Parasite; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Others; Proteases/Proteasome
	Dehydrocorydaline nitrate 是生物碱。Dehydrocorydaline 调节 Bax，Bcl-2蛋白表达，激活 caspase-7，caspase-8，并使 PARP 失活。它能增强 p38 MAPK 活化，具有抗炎、抗癌、抗疟疾等功效。
T6S0721	Orientin 荭草苷,Lutexin,Luteolin-8-glucoside	Others	Others
	Orientin (Luteolin-8-glucoside) 是天然存在的生物活性类黄酮，是一种有前景的神经保护剂，具有多种生物特性，如抗炎、抗肿瘤、抗氧化、保护心脏等。它有用于神经性疼痛研究潜力。
T5S2358	Dehydrocorydaline Dehydrocorydalin,脱氢紫堇碱,13-Methylpalmatine	BCL; PARP; p38 MAPK; Caspase; Parasite; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Proteases/Proteasome
	Dehydrocorydaline (13-Methylpalmatine) 是一种生物碱。它调节Bax，Bcl-2蛋白表达，激活caspase-7，caspase-8，并使PARP 失活。它能增强p38 MAPK 活化，具有抗炎、抗癌等功效。它具有强大的抗疟疾作用，并具低细胞毒性。
TMA0918	Neochamaejasmine A	Caspase	Apoptosis; Proteases/Proteasome
	Neochamaejasmin A can inhibit cellular (3)H-thymidine incorporation (IC 50 12.5 microg/mL) and subsequent proliferation of human prostate cancer LNCaP cells, it blocks cell cycle progression at the G1 phase by activating the p21 protein and ultimately pro
T36954	Nemorosone
	Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.1 Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma cells (IC50s = 3.1-6.3 μM), including several drug-resistant clones, but not MRC-5 human embryonic fibroblasts (IC50 = >40 μM).2 It increases DNA fragmentation in LAN-1 cells in a dose-dependent manner, and decreases N-Myc protein levels and phosphorylation of ERK1/2 by MEK1/2. Nem...

天然产物

Taurochenodeoxycholic acid sodium

Cat.No: TN2215

Synonym: 牛磺鹅去氧胆酸钠盐,Sodium taurochenodeoxycholate,牛磺鹅去氧胆酸钠

Target: Apoptosis, Endogenous Metabolite

Dihydrocapsaicin

Cat.No: T2163

Synonym: CCRIS1589,二氢辣椒素,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide

Target: Others, TRP/TRPV Channel

PHYTOSPHINGOSINE

Cat.No: T9503

Target: Apoptosis

Penicillic acid

Cat.No: T13815

Target: Apoptosis, Caspase, Antibacterial, Antibiotic

Ginsenoside Rh2

Cat.No: T2959

Synonym: 20(S)-Rh2,20S-Ginsenoside Rh2,人参皂苷Rh2,20(S)-Ginsenoside Rh2,人参皂苷 Rh2

Target: Apoptosis, EGFR, Caspase, Endogenous Metabolite

Cat.No: T3240

Synonym: dihydrogeraniol,香茅醇,β-香茅醇,(±)-β-Citronellol

Target: Reactive Oxygen Species

Cat.No: T5S1632

Synonym: 8-O-乙酰山栀苷甲酯,8-O-Acetylshanzhiside methyl ester,ND01

Target: VEGFR, TNF, NF-κB, Akt, Caspase

Dehydrocorydaline chloride

Cat.No: T10990

Synonym: 盐酸脱氢紫堇碱,13-Methylpalmatine chloride

Target: BCL, PARP, p38 MAPK, Caspase, Parasite, Autophagy

Dehydrocorydaline nitrate

Cat.No: T2S2362

Synonym: 去氢延胡索甲素硝酸盐,硝酸脱氢紫堇碱

Target: BCL, Others, PARP, p38 MAPK, Caspase, Parasite, Autophagy

Cat.No: T6S0721

Synonym: 荭草苷,Lutexin,Luteolin-8-glucoside

Target: Others

Dehydrocorydaline

Cat.No: T5S2358

Synonym: Dehydrocorydalin,脱氢紫堇碱,13-Methylpalmatine

Target: BCL, PARP, p38 MAPK, Caspase, Parasite, Autophagy

Neochamaejasmine A

Cat.No: TMA0918

Target: Caspase

Cat.No: T36954

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01057	Caspase-8 Protein, Human, Recombinant (His) Caspase-8,CAP4,Apoptotic cysteine protease...	Human	E. coli
	Caspase-8 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 21.9 kDa and the accession number is Q14790.
TMPH-01315	CASR Protein, Human, Recombinant (GST) CAP4,MCH5,Caspase-8,CASP-8,CASP	Human	E. coli
	CASR Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 93.6 kDa and the accession number is P41180.
TMPJ-01256	Caspase-10 Protein, Human, Recombinant (His) CASP10,FAS-Associated Death Domain Protein Interleukin-1B-Co...	Human	E. coli
	Caspase-10 (CASP10) is a 521 amino acid protein member of the Cysteine-Aspartic Acid Protease (Caspase) family. CASP10 contains two DED (Death Effector) domains and is detectable in most tissues. CASP10 cleavage by Granzyme B and autocatalytic activity generate the two active subunits: Caspase-10 subunit p23/17, Caspase-10 subunit p12. Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the execution-phase of cell apoptosis, the initiation and execution. Human ca...
TMPK-00277	TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc) TRAIL R2,TNFRSF10B,TRICK2,KILLER,DR5,TRAIL receptor 2,Fas-li...	Human	HEK293 Cells
	DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
TMPJ-00697	NOL3 Protein, Human, Recombinant (GST) Nop30,Myp,NOP,Apoptosis Repressor With CARD,Nucleolar Protei...	Human	E. coli
	Nucleolar Protein 3 is encoded by NOL3 gene; multiple transcript variants encoding different isoforms have been found for this gene. So far, Nucleolar protein 3 has show to have two Isoforms. Isoform 1 may be involved in RNA splicing.Isoform 2 may inhibit apoptosis.It has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53.
TMPJ-00215	Fas/CD95 Protein, Mouse, Recombinant (hFc) CD95,Apoptosis-mediating surface antigen FAS,TNFRSF6,Fas,Tum...	Mouse	HEK293 Cells
	Mouse Apoptosis-mediating surface antigen FAS (Fas) belongs to the death receptor subfamily of the TNF receptor superfamily and is designated TNFRSF6. Mouse Fas contains 1 death domain and 3 TNFR-Cys repeats. It detected in various tissues including thymus, liver, lung, heart, and adult ovary. As a receptor for TNFSF6/FASLG, The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which...
TMPH-02521	PYCARD Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3. Involved ...
TMPY-04123	CEACAM1 Protein, Human, Recombinant (His & hFc) CEACAM‑1,carcinoembryonic antigen-related cell adhesion mole...	Human	HEK293 Cells
	CEACAM1 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 71.4 kDa and the accession number is P13688-8.
TMPK-00276	TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (His & Avi) ZTNFR9,DR5TRICK2B,DR5,TRAIL receptor 2,TRICKB,TNFRSF10B,TRIC...	Human	HEK293 Cells
	DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
TMPY-02831	Caspase-7 Protein, Human, Recombinant (His) ICE-LAP3,LICE2,MCH3,CASP-7,caspase 7, apoptosis-rel...	Human	E. coli
	Caspase 7, also known as caspase-7 and MCH3, belongs to the cysteine-aspartic acid protease (caspase) family. Caspases play a role in the signal transduction pathways of apoptosis, necrosis and inflammation. There are two major classes of caspases: initiators and effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with, upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector caspases (-3,-6,-7) are r...
TMPJ-00696	NOL3 Protein, Human, Recombinant Apoptosis Repressor With CARD,Nucleolar Protein of 30 kDa,Nu...	Human	E. coli
	Nucleolar protein 3 is encoded by NOL3 gene. Multiple transcript variants encoding different isoforms have been found for this gene. So far, Nucleolar protein 3 has show to have two Isoforms. Isoform 1 may be involved in RNA splicing. Isoform 2 functions as an apoptosis repressor that blocks multiple modes of cell death. It inhibits extrinsic apoptotic pathways through two different ways. Firstly, it by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex ...
TMPY-02213	RAIDD Protein, Human, Recombinant (His) RAIDD,MRT34,CASP2 and RIPK1 domain containing adaptor with d...	Human	E. coli
	Death domain-containing protein CRADD, also known as Caspase and RIP adapter with death domain, RIP-associated protein with a death domain, CRADD and RAIDD, is a protein which is constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney. CRADD / RAIDD contains oneCARD domain and onedeath domain. CRADD / RAIDD contains a death domain involved in the binding of RIP protein. The CARD domain mediates the ...
TMPY-01176	cIAP1 Protein, Human, Recombinant (Avi) Hiap-2,API1,HIAP2,RNF48,baculoviral IAP repeat cont...	Human	E. coli
	The cellular inhibitor of apoptosis protein-1 (cIAP1) is a member of the Inhibitor of Apoptosis family proteins are (IAP) whose members are characterized by a novel domain of about 70 amino acids termed baculoviral IAP repeats (BIRs). The BIR domains of cIAP1 and cIAP2 bind to caspases, the key effector proteases of apoptosis. The IAP protein family which can enhance cell survival are crucial regulators of programmed cell death. Both cIAP1 and cIAP2 are the E3 ubiquitin protein isopeptide ligase...
TMPH-01705	Mucin-1/MUC1 Protein, Human, Recombinant (His)	Human	E. coli
	Mucin-1/MUC1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.2 kDa and the accession number is P15941-8.
TMPJ-00808	CD45RA Protein, Human, Recombinant (His) PTPRC,CD45R,CD45,LCA,protein tyrosine phosphatase, receptor ...	Human	HEK293 Cells
	CD45RA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 100-135 KDa and the accession number is P08575-8.
TMPY-00717	CEACAM1 Protein, Human, Recombinant (His) CEACAM‑1,BGP1,BGP,carcinoembryonic antigen-related cell adhe...	Human	HEK293 Cells
	CEACAM1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44.8 kDa and the accession number is P13688-8.
TMPJ-00828	Tau-F Protein, Human, Recombinant Neurofibrillary tangle protein,Paired helical filament-tau,M...	Human	E. coli
	Tau proteins are proteins which contain four Tau/MAP repeats. They promote microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. The tau proteins are the product of alternative splicing from a single gene that in humans is designated MAPT. When tau proteins are def...
TMPY-00668	APP/Protease nexin-II Protein, Human, Recombinant (hFc) CTFγ,amyloid beta (A4) precursor protein,AAA,ABPP,CVAP,APPI,...	Human	HEK293 Cells
	APP/Protease nexin-II Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 101 kDa and the accession number is P05067-8.
TMPJ-01330	CD299 Protein, Human, Recombinant (His & Flag) DC-SIGNR,L-SIGN,CD299,CD209L,LSIGN,C-type lectin domain fami...	Human	HEK293 Cells
	CD299 is also known as DC-SIGNR and CLEC4M, is a type II integral membrane protein. DC-SIGNR exists as a homotetramer, and the tandem repeat domain, also called neck domain, mediates oligermerization. Multiple human DC-SIGN/CD209 splice forms exist, generating both membrane-bound and soluble forms. DC-SIGNR is ragarded as a pathogen-recognition receptor involved in peripheral immune surveillance in liver, and probably mediate the endocytosis of pathogens which are subsequently degraded in lysoso...
TMPY-06707	Mucin-1/MUC1 Protein, Human, Recombinant (aa 1-173, His) ADMCKD,PEMT,KL-6,ADMCKD1,H23AG,mucin 1, cell surface associa...	Human	HEK293 Cells
	Mucin-1/MUC1 Protein, Human, Recombinant (aa 1-173, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.49 kDa and the accession number is P15941-8.

重组蛋白

Caspase-8 Protein, Human, Recombinant (His)

Cat.No: TMPH-01057

Species: Human

Expression System: E. coli

CASR Protein, Human, Recombinant (GST)

Cat.No: TMPH-01315

Species: Human

Expression System: E. coli

Caspase-10 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01256

Species: Human

Expression System: E. coli

TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00277

Species: Human

Expression System: HEK293 Cells

NOL3 Protein, Human, Recombinant (GST)

Cat.No: TMPJ-00697

Species: Human

Expression System: E. coli

Fas/CD95 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00215

Species: Mouse

Expression System: HEK293 Cells

PYCARD Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02521

Species: Mouse

Expression System: E. coli

CEACAM1 Protein, Human, Recombinant (His & hFc)

Cat.No: TMPY-04123

Species: Human

Expression System: HEK293 Cells

TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00276

Species: Human

Expression System: HEK293 Cells

Caspase-7 Protein, Human, Recombinant (His)

Cat.No: TMPY-02831

Species: Human

Expression System: E. coli

NOL3 Protein, Human, Recombinant

Cat.No: TMPJ-00696

Species: Human

Expression System: E. coli

RAIDD Protein, Human, Recombinant (His)

Cat.No: TMPY-02213

Species: Human

Expression System: E. coli

cIAP1 Protein, Human, Recombinant (Avi)

Cat.No: TMPY-01176

Species: Human

Expression System: E. coli

Mucin-1/MUC1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01705

Species: Human

Expression System: E. coli

CD45RA Protein, Human, Recombinant (His)

Cat.No: TMPJ-00808

Species: Human

Expression System: HEK293 Cells

CEACAM1 Protein, Human, Recombinant (His)

Cat.No: TMPY-00717

Species: Human

Expression System: HEK293 Cells

Tau-F Protein, Human, Recombinant

Cat.No: TMPJ-00828

Species: Human

Expression System: E. coli

APP/Protease nexin-II Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00668

Species: Human

Expression System: HEK293 Cells

CD299 Protein, Human, Recombinant (His & Flag)

Cat.No: TMPJ-01330

Species: Human

Expression System: HEK293 Cells

Mucin-1/MUC1 Protein, Human, Recombinant (aa 1-173, His)

Cat.No: TMPY-06707

Species: Human

Expression System: HEK293 Cells

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