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Search Results for " 240 "

82

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T29067	Upacicalcet PLS-240,SK-1403,AJT-240	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Upacicalcet (AJT-240) 是一种静脉内拟钙剂，是一种可用于人血液透析的 SHPT，通过直接作用于甲状旁腺细胞膜钙敏感受体来抑制过量的甲状旁腺激素 (PTH) 分泌，从而降低血液中的 PTH 水平。 3 Upacicalcet 是钙敏感受体的正变构调节剂，可预防大鼠腺嘌呤诱导的继发性甲状旁腺功能亢进模型中的血管钙化和骨骼疾病。
T3535	ML240	p97	Ubiquitination
	ML240 是一种选择性的 ATP 竞争性 p97 抑制剂，IC50值为 100 nM。
T67842	ERG240 EGR240	Others	Others
	ERG240 是支链氨基酸转氨酶 1 (BCAT1) 抑制剂。ERG240 有潜力用于癌症、类风湿性关节炎和骨病相关研究。
T29236	ZTZ240 ZTZ 240,ZTZ-240
	ZTZ240, a KCNQ2 K+ channel activator, offers a new target to treat hyperexcitability disorders.
T30666	C.I. Food Blue 1-aluminum lake EINECS 240-589-3,Indigotine-aluminum lake,Acid Blue 74-aluminum lake,Pigment Blue 63
	C.I. Food Blue 1-aluminum lake is a type of colorant.
T40495	Elastase from porcine pancreas 弹性蛋白酶,EC 3.2.1.35	Others	Others
	Elastase from porcine pancreas 由 240 个氨基酸残基组成，是一种丝氨酸蛋白酶，可以水解蛋白质和多肽。它可诱发仓鼠气肿。
T5048	SSR240612	Bradykinin Receptor	GPCR/G Protein
	SSR240612 是口服有活性的非肽类缓激肽 B1 (bradykinin B1) 受体特异性拮抗剂。
T14501	BAY-2402234	Dehydrogenase; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	BAY-2402234 是一种选择性二氢乳清酸脱氢酶的抑制剂，可研究骨髓恶性肿瘤。
T2081	LY2409881 trihydrochloride LY2409881	Apoptosis; IκB/IKK	Apoptosis; NF-κB
	LY2409881 trihydrochloride 是一种新型 IKK2 特异性抑制剂，IC50为 30 nM。
T61122	ZINC12409120 R-4584	ERK	MAPK
	ZINC12409120 (R-4584) 是一种具有选择性的 ERK 抑制剂。ZINC12409120 对ERK具有抑制作用，IC50 为 5.0 μM。ZINC12409120 通过干扰 FGF23:α-Klotho 的相互作用而抑制 ERK 活性。
T2248	AS-605240 5-(6-喹噁啉yl亚甲基)-2,4-噻唑烷二酮,AS 605240	PI3K; Autophagy	Autophagy; PI3K/Akt/mTOR signaling
	AS-605240 是一种有效且特异性的 PI3Kγ 抑制剂，IC50值为 8 nM，Ki 值为 7.8 nM。
TP1127L1	Nemifitide acetate(173240-15-8 free base) INN 00835 acetate	5-HT Receptor	GPCR/G Protein; Neuroscience
	Nemifitide acetate(173240-15-8 free base) (INN 00835 acetate) 是一种合成的五肽抗抑郁药，具有快速起效的潜力。它是黑色素细胞抑制因子 (MIF) 的肽类似物。
TQ0139	VU 0240551 N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide,VU0240551-2-D4	Potassium Channel; Calcium Channel; HER	Angiogenesis; JAK/STAT signaling; Membrane transporter/Ion channel; Metabolism; Tyrosine Kinase/Adaptors
	VU 0240551 是神经元 K-Cl 协同转运蛋白 KCC2 抑制剂的特异性拮抗剂，IC50 为 560 nM。 VU 0240551 抑制 L 型钙通道和 hERG。
T13248	UK-240455	NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	UK-240455是一种有效的且具有选择性的 N-甲基 D-天冬氨酸 (NMDA) 甘氨酸受体拮抗剂，具有神经保护作用和改善帕金森病模型的运动的功能，是治疗帕金森病的潜在候选化合物。
T61702	SRI-37240
	SRI-37240 is a powerful inhibitor of premature termination codons (PTCs). It effectively suppresses CFTR nonsense mutations and induces changes in cellular translation termination at PTCs in HEK293T cells. Additionally, when combined with G418, SRI-37240 restores CFTR function in primary bronchial epithelial cells [1].
T16889	SJ572403 SJ403	Others	Others
	SJ572403 是一种无序蛋白 p27 的抑制剂，对于 p27-KID 的 D2 亚结构域内的特定区域的 Kd 为 2.2 mM。 SJ572403 可用于研究具有内在无序蛋白质的疾病。
T32490	L-161240 L-161,240	Antibacterial	Microbiology/Virology
	L-161240 是一种与脂质A生物合成有关的抗菌剂，在DEACET测定IC50值为 30 nM，并且对野生型大肠杆菌的MIC值为1-3μg/ mL。
T15802	LY2183240	FAAH; Autophagy	Autophagy; Metabolism; Neuroscience
	LY2183240 是大麻素摄取阻滞剂。它是内源性大麻素降解酶脂肪酸酰胺水解酶的有效共价抑制剂。它抑制脂肪酸酰胺水解酶 (FAAH) 活性，IC50 为12.4 nM。它也抑制其他几种脑丝氨酸水解酶，对 MAG 脂肪酶、bh6 和 KIAA1363 的 IC50分别为 5.3、0.09 和 8.2 nM。
T29124	VU0240382 VU-0240382,VU 0240382
	VU0240382 is a selective positive allosteric modulators of metabotropic glutamate receptor subtype 5.
T16678	PSN632408	Others	Others
	PSN632408 is an optimized agonist of GPR119 receptors that display similar potency to OEA at both recombinant mouse and human GPR119 receptors (EC50: 5.6 and 7.9 uM, respectively).
T28005	MDL-100240
	MDL-100240 is a dual inhibitor of angiotensin-converting enzyme (ACE) and neprilysin with a balanced activity. MDL 100240 shows an impressive effectiveness both in preventing and in regressing hypertension-induced vascular remodeling and cardiac hypertrop
T25885	NSC12404 CID 224134,CID224134,CID-224134,NSC 12404,NSC-12404
	NSC-12404 is a selective non-lipid LPA2/3 agonist.
T19429	MK-6240	Others	Others
	MK-6240 is a tau positron emission tomography (PET) tracer for neurofibrillary tangles (NFTs). MK-6240 exhibits high specificity and selectivity for binding to NFTs.
T30091	AP-22408 UNII-3U3L5QR4KV,AC1L9I7C,AP22408,CC1
	AP-22408 is an inhibitor of SRC tyrosine kinase.
T25234	CH5447240 CH 5447240,CH-5447240
	CH5447240 is an effective Human Parathyroid Hormone Receptor 1 (hPTHR1) Agonist for the treatment of Hypoparathyroidism. CH5447240 showed a potent in vitro hPTHR1 agonist effect (EC20: 3.0 nM; EC50: 12 nM). It showed 55% oral bioavailability and a signifi
T13342L	WIN site inhibitor 1 TFA (2407457-36-5 free base) WIN site inhibitor 1 TFA	Others	Others
	WIN site inhibitor 1 TFA is a WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5) inhibitor (Kd: 0.1 nM).
T28243	Ono 6240 Ono-6240,Ono6240
	Ono 6240 is an antagonist of platelet-activating factor. Ono 6240 prevents airway eosinophilia by inhibiting production of IL-2 and IL-5.
T34539	SB 414240 SB-414240,SB414240
	SB 414240 is a bioactive chemical.
T26096	RJR-2403 oxalate RJR 2403 oxalate,Rivanicline oxalate,TC-2403,Metanicotine
	RJR-2403 oxalate is a highly selective agonist of α4β2 subtype nicotinic receptor.
T30662	C.I. 74240 NSC 324570,NSC-324570,NSC324570
	C.I. 74240 is a copper-containing dye used as a gelling agent for lubricants, for staining of bacteria and for the dyeing of histiocytes and fibroblasts in vivo.
T41101	LY2409881 LY2409881
	LY2409881 is a selective IκB kinase β ( IKK2 ) inhibitor with an IC 50 of 30 nM.
T34475	S24014 S-24014,S 24014
	S24014 is a bioactive chemical.
T22896	L-655,240	Others	Others
	L-655,240 is a thromboxane A2/prostaglandin endoperoxide receptor antagonist.
T36246	SJF 8240
	c-MET degrader. Comprises MET inhibitor foretinib (GSK 1363089; Cat. No. 6056) joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Degrades c-MET within 6 hours in vitro. Inhibits agonist-driven AKT phosphorylation and GTL16 cell proliferation (IC50 = 66.7 nM). Also degrades exon-14-deleted c-MET in Hs746T cells.
T27668	JNJ-2408068 R170591,R 170591,HE066500,R-170591,HE-066500,HE 066500
	JNJ-2408068 is an inhibitor of respiratory syncytial virus (RSV). JNJ-2408068 exhibited potent antiviral activity with EC50 of 2.1 nM. A similar inhibitory effect was observed in a RSV-mediated cell fusion assay (EC50= 0.9 nM). JNJ-2408068 interferes with
T23755	AS1468240 AS 1468240,AS-1468240
	AS1468240 is a factor Xa inhibitor. It has significant oral anticoagulant activity.
T23235	RJR-2403 hemioxalate	Others	Others
	RJR-2403 hemioxalate is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM). RJR-2403 hemioxalate > 1,000 fold selectivity than α7 receptors(Ki= 36000 nM).
T29724	AGN 192240 AGN-192240,AGN192240
	AGN 192240 is a biochemical.
T11545L	hDDAH-1-IN-2 sulfate (2408834-77-3 free base) hDDAH-1-IN-2 sulfate	Others	Others
	hDDAH-1-IN-2 sulfate is an orally active human dimethylarginine dimethylaminohydrolase-1 (hDDAH-1) inhibitor.
T30857	CGS 24012 CGS24012,CGS-24012
	CGS 24012 is a bioactive chemical.
T28530	RG-102240 RG102240,RG 102240
	RG-102240 acts as a transcription inducer for use in induceable gene expression systems.
T37558	Necrostatin-5 Nec-5	RIP kinase; Necroptosis	Apoptosis; NF-κB
	Necrostatin-5 (Nec-5)是一种RIP1激酶的选择性抑制剂，也是一种细胞坏死抑制剂，可防止TNF-α处理的fadd 缺陷Jurkat 细胞死亡，EC50值为240 nM。
T9075	BDP-13176	Others	Others
	BDP-13176 是fascin 1抑制剂，Kd=90 nM，IC50=240 nM。它具有成为抗转移剂的潜力。
T21938	AS-041164	PI3K	PI3K/Akt/mTOR signaling
	AS-041164 是选择性的，具有口服活性的PI3Kγ亚型抑制剂，IC50=70 nM。它对 PI3Kα (IC50:240 μM)，PI3Kβ (IC50:1.45 μM) 和 PI3Kδ (IC50:1.70 μM) 的活性较低。它具有抗炎活性。
T40236	ART812 ART812	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	ART812 is an orally active inhibitor of DNA polymerase Polθ, possessing an IC50 value of 7.6 nM. Additionally, ART812 exhibits a cell-based microhomology-mediated end joining (MMEJ) IC50 value of 240 nM.
T6726	VU0361737 ML-128,VU 0361737	GluR	Neuroscience
	VU0361737 (ML-128) 是一种高效选择性的，中枢神经系统渗透性的代谢型谷氨酸受体 4(mGluR4)正变构调节剂，对人类和大鼠 mGluR4作用的EC50值分别为 240 和 110 nM。它具有神经保护作用，有用于帕金森氏病的研究潜力。
T6644	Rolipram SB 95952,ZK 62711,咯利普兰,(R,S)-Rolipram	HIV Protease; Antibacterial; PDE	Metabolism; Microbiology/Virology; Proteases/Proteasome
	Rolipram (SB 95952) 是一种磷酸二酯酶 PDE4的选择性抑制剂，抑制 PDE4A，PDE4B 和 PDE4D 的 IC50分别为 3 nM，130 nM 和 240 nM。
T7648	HA-100	Myosin; PKA; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	HA-100 是蛋白激酶和ROCK 抑制剂，抑制PKG，PKA，PKC 和MLC 激酶的IC50值分别为 4、8、12 和 240 μM。
T6036	Brivanib BMS-540215,布立尼布	EGFR; VEGFR; FGFR; Autophagy	Angiogenesis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Brivanib (BMS-540215) 是一种针对 VEGFR2 的 ATP 竞争性抑制剂，IC50 为 25 nM。它对 VEGFR-1 和 FGFR-1 具有中等效力，对 VEGFR2 的选择性是对 PDGFR-β 的 240 倍。
T6787	BIO-acetoxime BIA,GSK-3 Inhibitor X	Apoptosis; GSK-3; HSV	Apoptosis; Microbiology/Virology; PI3K/Akt/mTOR signaling; Stem Cells
	BIO-acetoxime (GSK-3 Inhibitor X) 是一种 GSK3α/β 抑制剂，IC50值均为 10 nM，具有抗惊厥和抗感染作用。

化合物

Cat.No: T29067

Synonym: PLS-240,SK-1403,AJT-240

Target: Calcium Channel

Cat.No: T3535

Target: p97

Cat.No: T67842

Synonym: EGR240

Target: Others

Cat.No: T29236

Synonym: ZTZ 240,ZTZ-240

C.I. Food Blue 1-aluminum lake

Cat.No: T30666

Synonym: EINECS 240-589-3,Indigotine-aluminum lake,Acid Blue 74-aluminum lake,Pigment Blue 63

Elastase from porcine pancreas

Cat.No: T40495

Synonym: 弹性蛋白酶,EC 3.2.1.35

Target: Others

Cat.No: T5048

Target: Bradykinin Receptor

Cat.No: T14501

Target: Dehydrogenase, DNA/RNA Synthesis

LY2409881 trihydrochloride

Cat.No: T2081

Synonym: LY2409881

Target: Apoptosis, IκB/IKK

Cat.No: T61122

Synonym: R-4584

Target: ERK

Cat.No: T2248

Synonym: 5-(6-喹噁啉yl亚甲基)-2,4-噻唑烷二酮,AS 605240

Target: PI3K, Autophagy

Nemifitide acetate(173240-15-8 free base)

Cat.No: TP1127L1

Synonym: INN 00835 acetate

Target: 5-HT Receptor

Cat.No: TQ0139

Synonym: N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide,VU0240551-2-D4

Target: Potassium Channel, Calcium Channel, HER

Cat.No: T13248

Target: NMDAR, iGluR

Cat.No: T61702

Cat.No: T16889

Synonym: SJ403

Target: Others

Cat.No: T32490

Synonym: L-161,240

Target: Antibacterial

Cat.No: T15802

Target: FAAH, Autophagy

Cat.No: T29124

Synonym: VU-0240382,VU 0240382

Cat.No: T16678

Target: Others

Cat.No: T28005

Cat.No: T25885

Synonym: CID 224134,CID224134,CID-224134,NSC 12404,NSC-12404

Cat.No: T19429

Target: Others

Cat.No: T30091

Synonym: UNII-3U3L5QR4KV,AC1L9I7C,AP22408,CC1

Cat.No: T25234

Synonym: CH 5447240,CH-5447240

WIN site inhibitor 1 TFA (2407457-36-5 free base)

Cat.No: T13342L

Synonym: WIN site inhibitor 1 TFA

Target: Others

Cat.No: T28243

Synonym: Ono-6240,Ono6240

Cat.No: T34539

Synonym: SB-414240,SB414240

RJR-2403 oxalate

Cat.No: T26096

Synonym: RJR 2403 oxalate,Rivanicline oxalate,TC-2403,Metanicotine

Cat.No: T30662

Synonym: NSC 324570,NSC-324570,NSC324570

Cat.No: T41101

Synonym: LY2409881

Cat.No: T34475

Synonym: S-24014,S 24014

Cat.No: T22896

Target: Others

Cat.No: T36246

Cat.No: T27668

Synonym: R170591,R 170591,HE066500,R-170591,HE-066500,HE 066500

Cat.No: T23755

Synonym: AS 1468240,AS-1468240

RJR-2403 hemioxalate

Cat.No: T23235

Target: Others

Cat.No: T29724

Synonym: AGN-192240,AGN192240

hDDAH-1-IN-2 sulfate (2408834-77-3 free base)

Cat.No: T11545L

Synonym: hDDAH-1-IN-2 sulfate

Target: Others

Cat.No: T30857

Synonym: CGS24012,CGS-24012

Cat.No: T28530

Synonym: RG102240,RG 102240

Cat.No: T37558

Synonym: Nec-5

Target: RIP kinase, Necroptosis

Cat.No: T9075

Target: Others

Cat.No: T21938

Target: PI3K

Cat.No: T40236

Synonym: ART812

Target: DNA/RNA Synthesis

Cat.No: T6726

Synonym: ML-128,VU 0361737

Target: GluR

Cat.No: T6644

Synonym: SB 95952,ZK 62711,咯利普兰,(R,S)-Rolipram

Target: HIV Protease, Antibacterial, PDE

Cat.No: T7648

Target: Myosin, PKA, PKC

Cat.No: T6036

Synonym: BMS-540215,布立尼布

Target: EGFR, VEGFR, FGFR, Autophagy

Cat.No: T6787

Synonym: BIA,GSK-3 Inhibitor X

Target: Apoptosis, GSK-3, HSV

Cat. No.	Product Name	Target	Signaling Pathways
T4760	KSD 2405 3-羟基苯甲醇,3-Hydroxybenzyl alcohol	Others; Endogenous Metabolite	Metabolism; Others
	KSD 2405 (3-Hydroxybenzyl alcohol) 是内源性代谢产物的一种。
TN6414	Plantanone B
	Plantanone C exhibited moderate antioxidant activity against DPPH radical scavenging activity,with an IC50 value of 240. 2 μmol·L~(-1).
T38015	Herquline A
	Herquline A is an alkaloid fungal metabolite originally isolated from P. herquei. It inhibits cell death induced by influenza A strain A/PR/8/34 in MDCK cells with an IC50 value of 10 μg/ml and inhibits viral replication in a plaque assay in a concentration-dependent manner. Herquline A also inhibits platelet aggregation induced by ADP and platelet-activating factor (PAF) in vitro (IC50s = 180 and 240 μM, respectively).

天然产物

Cat.No: T4760

Synonym: 3-羟基苯甲醇,3-Hydroxybenzyl alcohol

Target: Others, Endogenous Metabolite

Cat.No: TN6414

Cat.No: T38015

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