61
9
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8132 |
Iron sucrose
Iron saccharate,蔗糖铁,Sucroferric oxyhydroxide |
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
Iron sucrose (Sucroferric oxyhydroxide) 是一种静脉注射铁制剂,也是一种促氧化剂,可用于研究缺铁性贫血。 | |||
TD0098 |
Direct Red 80
Sirius Red,天狼猩红,Sirius Red F 3BA,C.I. direct red 80 |
Others | Others |
Direct Red 80 (Sirius Red) 是一种聚偶氮染料,在降解时不会释放联苯胺,比许多传统的直接染料更安全,主要用于胶原蛋白和淀粉样蛋白的染色方法。 | |||
T20622 |
Fomesafen
氟磺胺草醚,PP021,PP-021,PP 021 |
Others | Others |
Fomesafen (PP-021) 是原卟啉原 IX 氧化酶的选择性抑制剂。Fomesafen (PP-021) 用作除草剂,具有低毒性和高选择性的优点。 | |||
T39529 |
AT-121 hydrochloride
|
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
AT-121 hydrochloride 是一种 nociception 和 mu 阿片受体 (mu opioid receptor)的双重激动剂,Ki 值分别为 3.67 和 16.49 nM。AT-121 hydrochloride 是一种安全、无成瘾性且科缓解疼痛的化合物,具有抗伤害和止痛活性。 | |||
T35862 |
Cucurbit[8]uril
|
Others | Others |
Cucurbit[8]uril is a highly effective and safe supramolecular compound that promotes protein heterodimerization. It selectively induces the heterodimerization of methylviologen and naphthalene functionalized proteins, demonstrating its specificity and versatility. Additionally, Cucurbit[8]uril shows exceptional oral activity and low toxicity, making it a promising candidate for various pharmaceutical and biotechnological applications. | |||
T10570 |
Fostemsavir Tris
BMS-663068 Tris |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Fostemsavir Tris (BMS-663068 Tris) 是一种 HIV-1附着抑制剂。 | |||
T14932 |
Ceruletide
Cerulein,Caerulein,雨蛙素,FI-6934 |
cholecystokinin | GPCR/G Protein |
Ceruletide (Caerulein) 是一种十肽,是一种安全有效的胆囊收缩剂,是一种胆囊收缩素受体激动剂,对胆囊肌肉和胆管有直接的痉挛性作用。 | |||
T2322 |
Fimasartan
非马沙坦,BR-A-657,Kanarb |
Apoptosis; RAAS | Apoptosis; Endocrinology/Hormones |
Fimasartan (BR-A-657) 是血管紧张素受体 AT1 非肽类拮抗剂,用于研究高血压和心力衰竭。 | |||
T22415 |
Resorantel
|
Parasite | Microbiology/Virology |
Resorantel 是一种驱虫剂,用于研究牛和羊的寄生虫病,也被用于研究G. aegypticus。 | |||
T10385 |
ASP-4058
|
S1P Receptor; LPL Receptor | GPCR/G Protein |
ASP-4058 是一种鞘氨醇磷酸受体 1 和 5 (S1P1 and S1P5) 的二代激动剂,具有选择性、安全性和口服活性。ASP-4058能改善小鼠实验性自身免疫性脑脊髓炎。 | |||
T60522 |
Letosteine
Viscotiol |
Others | Others |
Letosteine (Viscotiol) 是具有口服活性、有效且安全的祛痰剂, 可用于研究急性或慢性呼吸道疾病,如支气管肺炎。Letosteine 能够溶解支气管粘液并减轻呼吸道炎症症状,从而实现恢复肺部气体交换和自然防御机制。 | |||
T66491 |
4-(1-Phenylethyl)resorcinol
4-(1-Phenylethyl)benzene-1,3-diol,Phenylethyl resorcinol |
Others | Others |
4-(1-Phenylethyl)resorcinol (4-(1-Phenylethyl)benzene-1,3-diol) 是一种亮肤剂,属于化妆品添加。它的作用是抑制黑色素的产生,减少黑斑、色素沉着和肤色不均的出现,提亮肤色减少皮肤暗沉。4-(1-Phenylethyl)resorcinol 在化妆品行业一般认为是安全的,在多个国家和地区广泛使用。 | |||
T14932L1 |
Ceruletide Ammonium Salt
Caerulein Ammonium Salt,Ceruletide Ammonium Salt(17650-98-5 Free base),FI-6934 Ammonium Salt,Cerulein Ammonium Salt |
cholecystokinin | GPCR/G Protein |
Ceruletide Ammonium Salt 是一种十肽,起源于热带青蛙的皮肤,是一种有效的胆囊收缩素受体 (cholecystokinin receptor) 激动剂,也是一种安全有效的胆囊收缩剂,对胆囊肌肉和胆管有直接的痉挛性作用。Ceruletide Ammonium Salt 具有镇静活性,可用于研究慢性精神分裂症。 | |||
T4615 |
Balsalazide sodium hydrate
巴柳氮钠水合物,Balsalazide disodium dihydrate,巴柳氮钠,Balsalazide disodium salt dihydrate,Balsalazide disodium |
STAT; Interleukin | Immunology/Inflammation; JAK/STAT signaling; Stem Cells |
Balsalazide sodium hydrate (Balsalazide disodium) 可通过调节IL-6/STAT3通路起抑癌作用,可用于治疗炎症性肠病。 | |||
T37610 |
AT-121
|
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
AT-121 是一种双重μ-阿片和神经肽受体部分激动剂(Kis 分别为 16.49 和 3.67 nM)。它能刺激[35S]GTPγS 与表达μ-阿片受体或神经肽受体的细胞膜结合(EC50s 分别为 19.6 和 34.7 nM)。AT-121(0.003-0.03 mg/kg)能以剂量依赖的方式降低辣椒素诱导的热异感,但不会增加恒河猴的搔抓活动。在恒河猴药物自我给药试验中,AT-121 每次注射剂量为 0.3 至 10 μg/kg,它缺乏强化作用(一种潜在的滥用标志),不能减少食物颗粒的强化作用。AT-121(0.01 或 0.03 毫克/千克)不会诱发恒河猴的超痛觉,超痛觉是产生耐受性的标志。AT-121 是一种安全、无成瘾性的缓解疼痛药,具有抗伤害和止痛作用。 | |||
T61268 |
Vutiglabridin
HSG4112 |
Phosphatase | Metabolism |
Vutiglabridin (HSG4112) 是一种新型且安全的PON2调节剂,是一个外消旋化合物。Vutiglabridin 是Glabridin 的优化结构类似物,比Glabridin 在减重效果和化学稳定性方面更加优越。Vutiglabridin 通过靶向线粒体对氧磷酶-2改善mptp 诱导的帕金森病小鼠的神经变性。Vutiglabridin 是一种治疗肥胖的临床2期药物,在PD 模型中对对线粒体PON2具有治疗作用。Vutiglabridin 渗透到大脑,结合PON2,恢复1-甲基-4-苯基吡啶(MPP*)诱导的SH-SY5Y 神经母细胞瘤细胞线粒体功能障碍。Vutiglabridin 在小鼠实验中 显著减轻了1-甲基-4苯基-1,2,3,6-四氢吡啶(MPTP)诱导的PD 模型小鼠的运动障碍和多巴胺能神经元损伤。 | |||
T25506 |
Homotyrosine, (+)-
alpha-Homotyrosine, (+)-,L-Homotyrosine |
||
Homotyrosine, (+)- is an amino acid used as a very stable, selective, and renally safe sodium channel blocker. | |||
T70473 |
Parapenzolate Free Base
|
||
Parapenzolate Free Base is a safe and effective anticholinergic drug possessing antisecretory and antimotility properties and prolonged duration of action. Clinical investigation has shown that after an oral dose of the drug there was inhibition of both basal and histamine-stimulated acid outputs. | |||
T19851 |
Azintamide
Azinthiamide,Oragalin,Bilipurum,Colerin,BRN 0885011 |
||
Azintamide is a choleretic. It has shown effective and safe for dyspepsia symptoms when Domperidone therapy is not satisfactory. | |||
T33673 |
Niludipine
Niludipina,BAY-a 7168,Bay a 7168,Niludipinum |
||
Nirudipine is a double (2-propoxyethyl) analogist of nifedipine and a calcium channel blocker, which is also a safe anti-angina Ca2+ antagonist with a broad range of efficacy for all types of angina. At the same time, Niludipine is a highly effective drug | |||
T24995 |
Abediterol napadisylate
LAS100977 napadisylate |
||
Abediterol napadisylate is a novel long-acting β2-agonist in persistent asthma that is efficacy, safe, and tolerable. | |||
T11214 |
EPI-589
|
Others | Others |
EPI-589, a quinone derivative and oxidoreductase enzyme inhibitor, is considered safe and well tolerated, showing promise for the treatment of amyotrophic lateral sclerosis (ALS). | |||
T72016 |
ST101036
|
||
MC activators have recently been described as safe and effective vaccine adjuvants. ST101036 exhibited high degranulation potency in both human and mouse MCs. | |||
T20046 |
D & C Red no. 27
D &,Solvent Red 48,C Red no. 27,D and C Red No. 27,Japan Red 218,Phloxine BBN Supra |
||
D&C Red No. 27 Aluminum Lake is a drug and cosmetic synthetic dye. The FDA lists it as a safe additive for drugs and cosmetics as per FDA standards. | |||
T25375 |
Enprostil
RS-84135,RS 84135,Gardrin,RS84135 |
||
Enprostil is a synthetic PGE2 analog that has an inhibitory effect on gastric acid secretion, a mucoprotective effect, and a postprandial lowering effect on gastrin. It has efficient and safe in the therapy of gastroduodenal ulcers. | |||
T72146 |
Loxoprofenol-SRS tromethamine
HR1405–01 |
||
Loxoprofenol-SRS tromethamine (HR1405-01) 为Loxoprofen的活性代谢物,为一种可静脉注射的安全非甾体抗炎药(NSAID),展现出良好的抗炎及镇痛效果。 | |||
T14115 |
Acoziborole
SCYX-7158,AN5568 |
Others | Others |
Acoziborole (SCYX-7158) 是一种安全的、有效的、结构新颖的抗原虫剂,是一种 benzoxaborole 的衍生物,可用于人类非洲锥虫病 (HAT) 的研究。Acoziborole 对 T. b. brucei S427 菌株的MIC 值为 0.6 µg/mL。 | |||
T7772 |
Fast Green FCF
C.I. 42053,固绿 FCF,Food green 3,FD&C Green No. 3 |
Others | Others |
Fast Green FCF (FD&C Green No. 3) 是海绿色三芳基甲烷食用染料,最大吸收在625nm 处,将在电泳过程中的蛋白质染色,。 | |||
T12419L | PF-04634817 | CCR | Immunology/Inflammation; Microbiology/Virology |
PF-0463481 is safe and well-tolerated and has the potential for the study of diabetic nephropathy. PF-0463481 is an effective and orally active dual CCR2/CCR5 antagonist. It also has comparable human and rodent CCR2 potency (rat IC50=20.8 nM). PF-0463481 | |||
T28894 |
SZV558
SZV 558,SZV-558 |
||
SZV558 is a potent inhibitor of both human and rodent MAO-B. SZV558 is safe in high doses with no hERG and mutagenic activities and demonstrated neuroprotection in an in vivo chronic model of PD. | |||
T25543 |
Isoaminile citrate
|
||
Isoaminile citrate 是一种安全有效的中枢镇咳药。在动物实验中,它与 codeine 一样有效,但没有任何呼吸抑制作用。 | |||
T78305 |
Briquilimab
JSP-191 |
||
Briquilimab (JSP-191) 是针对 CD117 (c-Kit) 的无毒人源化单克隆抗体,用于消耗造血干细胞 (HSC)。它被应用于重度联合免疫缺陷 (SCID) 治疗中,以清空宿主骨髓生态位,为供体造血干细胞移植及免疫重建创造条件。 | |||
T70268 |
3A-MPLA
|
||
Monophosphoryl lipid A (MPLA) is a natural agonist for the toll-like receptor-4 (TLR4). It is useful as an adjuvant in immunization. MPLA is a safe prophylactic agent and has immunotherapeutic applications. It induces tumor necrosis factor and interleukin (IL)-1β, however not as efficient as lipopolysaccharide (LPS). MPLA improves immune response during bacterial sepsis infection. | |||
T79141 |
Mosnodenvir
JNJ-1802 |
Virus Protease | Microbiology/Virology |
Mosnodenvir(JNJ-1802)是一种泛血清型登革热抗病毒药物,表现出较高的耐药性屏障,同时安全性和耐受性均优良。它通过阻断NS3-NS4B相互作用来抑制病毒复制复合体。在小鼠模型中,Mosnodenvir展示了从皮摩尔到低纳摩尔量级的体外抗病毒效能。 | |||
T63912 | PDE4-IN-12 | ||
PDE4-IN-12 是强效的、安全性良好的 PDE4 泛型抑制剂,能够作用于 PDE4 (IC50: 3.5 nM, SI: 2.71) 和 PDE7 (IC50: 15 nM, SI: 4.27)。PDE4-IN-12 能够用于研究炎症性肠病 (IBDs)。 | |||
T62571 | Clomifene hydrochloride | ||
Clomifene hydrochloride 可以诱导排卵,能够用于不孕症。hydrochloride 是一种简单的、相对安全的、易于给药且耐受性良好的、口服具有活力的化合物。 | |||
T14932L |
Ceruletide Ammonium acetate
FI-6934 Ammonium acetate,Caerulein Ammonium acetate,Ceruletide Ammonium acetate (17650-98-5 free base) |
cholecystokinin | GPCR/G Protein |
Ceruletide Ammonium acetate (FI-6934 Ammonium acetate) 是一种胆囊收缩素 (CCK) 受体激动剂。它是一种安全有效的胆囊动力剂和小肠和胰腺外分泌兴奋剂。 | |||
T60792 | NMDA receptor antagonist-3 | ||
NMDA receptor antagonist-3 是NMDA 受体的拮抗剂。NMDA receptor antagonist-3 在 SH-SY5Y 和人脂肪间充质干细胞中具有显著的回收率(40.0 %,100 μM)和安全的毒理学特性。 | |||
T69133 | Etozolin HCl | ||
Etozolin HCl is a safe and effective diuretic agent in the treatment of acute cardiac failure. In isolated rings of guinea-pig aorta not responding to acetylcholine, the diuretic dexetozoline did not influence basal vascular tone but inhibited noradrenaline- and histamine-induced contractions. Dexetozoline has a very high bioavailability after oral administration and is fairly lipohilic. The half-life of etozolin is 2.5 h. Dexetozoline accumulates in cirrhosis. | |||
T74739 | Oleoyl-D-lysine | ||
Oleoyl-D-lysine是一种脂质基选择性GlyT2 (甘氨酸转运体-2) 抑制剂,具有逆转小鼠神经性疼痛及抗慢性神经性疼痛嗜睡作用,安全有效,不引发呼吸抑制。 | |||
T70000 |
Ebopiprant HCl
|
||
Ebopiprant, also known as OBE-022, is an Oral and Selective Prostaglandin F 2α Receptor Antagonist as an Effective and Safe Modality for the Treatment of Preterm Labor. OBE022 exhibits potent tocolytic effects on human tissues ex vivo and animal models in vivo without causing the adverse fetal side effects seen with indomethacin. | |||
T69709 | GST-HG131 | ||
GST-HG131 是一种特异性的乙肝病毒 (HBV) 表面抗原抑制剂,属于二氢苯并吡哆醛 (DBP) 类化合物。GST-HG131 抑制 HBsAg 和 HBeAg 的特异性和效力很强 (EC50=28.2 nM, 16.0 nM)。GST-HG131 还具有良好的动物安全性。 | |||
T61811 |
GPVI antagonist 3
|
||
GPVI antagonist 3 (Compound 2) is a potential antagonist that shows promising antiplatelet activity by selectively inhibiting the interaction between the Glycoprotein VI (GPVI) receptor and its ligands. It demonstrates potent inhibitory effects, with IC50 values of 1.01 μM for collagen, 1.92 μM for CRP, 7.24 μM for convulxin, and 51.74 μM for thrombin. GPVI is a major collagen receptor on platelets, making it an ideal target for safe and effective antithrombotic treatment. Therefore, GPVI antago... | |||
T63267 |
P-gp/BCRP-IN-1
|
||
P-gp/BCRP-IN-1 (compound 19) 是一种潜在的、相对安全的、口服有效的外排转运蛋白(P-gp 和 BCRP) 抑制剂。P-gp/BCRP-IN-1 通过抑制 P-gp 和BCRP 的外排功能产生耐药性逆转,P-gp/BCRP-IN-1可克服紫杉醇的耐药性,提高紫杉醇的口服生物利用度。 | |||
T63141 |
ASP-4058 hydrochloride
|
||
ASP-4058 hydrochloride 是一种选择性的、口服具有活力的的鞘氨醇磷酸受体 1 和 5 (S1P1and S1P5) 的二代激动剂。ASP-4058 hydrochloride 安全性良好,能够改善小鼠实验性自身免疫性脑脊髓炎。 | |||
T72563 |
HIV-1 inhibitor-49
|
||
HIV-1inhibitor-49 是一种口服有效的 HIV-1抑制剂,是一种 HEPT 类似物。HIV-1inhibitor-49 具有良好的药代动力学特征和有效的非核苷类逆转录酶 (Reverse Transcriptase ; IC50=30 nM) 抑制活性。HIV-1inhibitor-49 具有潜在的安全性,对小鼠无急性毒性。 | |||
T79022 |
BACE1-IN-13
|
Beta-Secretase | Neuroscience |
BACE1-IN-13 (Compound 36)为一种BACE1抑制剂,展现出口服活性,IC50为2.9 nM。该化合物在hAβ42细胞中显示出强效 (IC50=1.3 nM),证实了其心血管安全性,并在小鼠与狗的动物模型中有效降低Aβ42水平。 | |||
T62589 |
TRPC5-IN-4
|
||
TRPC5-IN-4 是一种有效且安全的TRPC 抑制剂,对TRPC5和TRPC4的IC50分别为 14.07 nM 和 65 nM。TRPC5-IN-4 对肝、肾细胞成分无损伤。TRPC5-IN-4 可用于慢性肾脏病的研究 (CKD)。 | |||
T62172 | Dual AChE-MAO B-IN-1 | ||
Dual AChE-MAO B-IN-1 (compound 15) 是一种安全的、代谢稳定的神经保护剂。Dual AChE-MAO B-IN-1 是一种强效的、口服具有活力的中枢神经系统渗透的人 AChE(IC50=550 nM) 和 MAO-B (IC50=8.2 nM)抑制剂,对 AChE 和 MAO-B 的 IC50 值分别为 550 nM、8.2 nM。 | |||
TD0004 |
Celfinder nucleic acid gel stain *10,000× concentrate in DMSO*
|
||
Celfinder is a new kind of nucleic acid dye, which has the advantages of safety and sensitivity, and can be used as a dye for various kinds of nucleic acid electrophoresis.Unlike EB, which is highly carcinogenic, Celfinder is a flower-like dye with low to |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T19137 |
4'-Methylacetophenone
|
Others | Others |
4′-methylacetophenone 是一种香料,普遍存在于食品中的挥发性化合物和某些天然复合物中。 | |||
T3237 |
Lecithin
Phospholutein,卵磷脂,L-α-磷脂酰胆碱,L-α-Phosphatidylcholine,Phosphatidylcholines |
Others; Endogenous Metabolite | Metabolism; Others |
Lecithin (L-α-Phosphatidylcholine) 被认为是安全的常规磷脂源。磷脂能够改变动物细胞膜的脂肪酸组成和微观结构。 | |||
T4S0675 |
Polygalasaponin V
瓜子金皂苷V,瓜子金皂苷 V |
Others | Others |
Polygalasaponin V 是一种三萜皂苷,分离自Polygala japonica 的地上部分。其中Polygala japonica 是民间的药用植物,在中国南方用作祛痰、抗菌、抗炎、抗抑郁药。 | |||
T4960 |
VASICINE
|
Anti-infection; AChR | Microbiology/Virology; Neuroscience |
Vasicine 是一种分离自Justicia adhatoda 中的喹唑啉类生物碱。它具有抗结核作用。 | |||
T3823 |
D-Pinitol
Pinitol,Inzitol,D-(+)-Pinitol,D-松醇,Methylinositol,3-O-Methyl-D-chiro-inositol |
Others; Influenza Virus | Microbiology/Virology; Others |
D-Pinitol (Methylinositol) 是一种存在于几种植物中,如松科和豆科植物的天然产物,具有抗病毒、杀幼虫、降血糖活性和心血管系统保护作用。 | |||
T3729 |
Ethyl gallate
Nipagallin A,Phyllemblin,gallic acid ethyl ester,没食子酸乙酯 |
MMP; NF-κB; Akt; Antibacterial | Cytoskeletal Signaling; Microbiology/Virology; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Ethyl gallate (gallic acid ethyl ester) 是一种非类黄酮酚过氧化氢清除剂。 | |||
T4439 |
sn-Glycero-3-phosphocholine
Choline Alfoscerate,甘磷酸胆碱,Glycerophosphocholine,Glycerophosphorylcholine,Alpha-GPC,Choline glycerophosphate,L-α-GPC |
Endogenous Metabolite; AChE | Metabolism; Neuroscience |
sn-Glycero-3-phosphocholine (Choline glycerophosphate) 是脑磷脂生物合成的前体,能够提高胆碱在神经组织中的生物利用度。它对认知功能有显著影响,同时具有良好的耐受性和安全性,因此能够用于阿尔茨海默病和痴呆症的研究。 | |||
TN4840 |
Psoromic acid
|
Others | Others |
Psoromic acid is a selective and covalent rab-prenylation inhibitor targeting autoinhibited RabGGTase, it shows antibacterial activities against Streptococcus gordonii and Porphyromonas gingivalis, and it is an effective and safe natural drug plausible fo | |||
TN1681 |
Gentianine
|
Others; TNF; transporter; PPAR | Apoptosis; DNA Damage/DNA Repair; Metabolism; Others |
Gentianine 是一种有效的 Swertiamarin 衍生物,具有抗糖尿病、抗精神病、抗炎、降血压、利尿等作用,具有被开发成一种安全的降压药物的潜力。 |