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23
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T81593 |
Osteoblast-Adhesive Peptide
|
||
Osteoblast-Adhesive Peptide是一种促进成骨细胞黏附的多肽,用于生物材料的化学修饰,具有牙科和骨科领域的潜在应用价值。 | |||
T39508 |
KY-02327
|
Others | Others |
KY-02327 是 KY-02061的一种类似物,具有代谢稳定性。KY-02327是Dishevelled (Dvl)-CXXC5相互作用抑制剂。KY-02327激活Wnt/β-catenin 途径,从而促进成骨细胞分化。 | |||
T7844 |
4-IPP
4-Iodo-6-phenylpyrimidine |
Others | Others |
4-IPP (4-Iodo-6-phenylpyrimidine) 是一种巨噬细胞迁移抑制因子 (MIF) 的特异性自杀底物,也是 MIF 的不可逆抑制剂。 | |||
T16159 |
Muramyl dipeptide
MDP |
NOD | Immunology/Inflammation; NF-κB |
Muramyl dipeptide (MDP) 是合成的免疫反应肽,由 N-乙酰壁酸与 L-Ala-D-isoGln 的短氨基酸链相连。它通过MAPK 途径上调 Runx2 基因表达,直接促进成骨细胞分化,通过降低 RANKL/OPG 比值间接抑制破骨细胞分化。它是通过Runx2诱导骨形成的诱导因子,也是NLRP1激动剂。 | |||
T8550 |
NDMC101
|
Others; NF-κB; Proteasome | NF-κB; Others; Proteases/Proteasome; Ubiquitination |
NDMC101 是有效的破骨细胞形成抑制剂,通过下调 NFATc1 调控基因表达抑制破骨细胞分化。它与 DPP4底物相似,通过抑制DPP4抑制早期 T 细胞激活。它能够用于骨疾病的研究,如类风湿关节炎、滑膜炎等。 | |||
T1810 |
Purmorphamine
Shh Signaling Antagonist VI |
Hedgehog/Smoothened; Smo; Autophagy | Autophagy; GPCR/G Protein; Stem Cells |
Purmorphamine (Shh Signaling Antagonist VI) 是平滑受体激动剂,EC50为 1 μM。它阻止 BODIPY-cyclopamine 与 Smo 结合。它也是成骨细胞分化的诱导剂。 | |||
T11048L |
DIPQUO hydrochloride
DIPQUO hydrochloride(1269365-82-3 Free base) |
Phosphorylase | Metabolism |
DIPQUO hydrochloride 是一种骨标记碱性磷酸酶 (ALP) 激活剂,在 C2C12 细胞中作用的 EC50 值为 6.27 μM。DIPQUO hydrochloride 通过激活 p38 MAPK-β 促进小鼠和人类的成骨细胞分化。 | |||
T22767 |
ER 50891
|
Retinoid Receptor | Metabolism |
ER-50891是一种强效的视黄酸受体α(RARα)拮抗剂。ER-50891能减少全价视黄酸的抑制作用并恢复骨形态生成蛋白2诱导的成骨细胞分化。 | |||
T60554 |
Schnurri-3 inhibitor-1
|
Others | Others |
Schnurri-3 inhibitor-1 是有效的 schnurri-3 抑制剂,schnurri-3是成人骨形成的重要调节因子。在成骨细胞系 Shn3FFL 中,Schnurri-3 inhibitor-1 通过 EF1alpha 启动子抑制 Shn3 蛋白表达 (AC50= 2.09 μM)。Schnurri-3 inhibitor-1 可用于骨质疏松症相关的研究。 | |||
TP1345 |
Kisspeptin-10, human (TFA)(374675-21-5,FREE)
|
GPR; Kisspeptin | Endocrinology/Hormones; GPCR/G Protein |
Kisspeptin-10, human (TFA)(374675-21-5,FREE) 是一种有效的血管收缩剂和血管生成抑制剂。 Kisspeptin-10,人类 TFA 通过其受体 GPR54 充当肿瘤转移抑制因子。 Kisspeptin-10-GPR54系统在胚胎肾发育中发挥重要作用。 Kisspeptin-10/GPR54 信号通过 NFATc4 介导的 BMP2 表达诱导成骨细胞分化 | |||
T27999 |
MDK-4624
AMPKα1 activator C13,C13, Compound 13 |
||
MDK-4624 is a AMPKα1 activator. MDK-4624 inhibits Helicobacter pylori-induced oxidative stresses and gastric epithelial cell apoptosis. MDK-4624 attenuates dexamethasone-induced osteoblast cell death. MDK-4624 potently inhibits melanoma cell proliferation | |||
T72008 |
E09241
|
||
E09241 is a novel OPG/RANKL upregulator, increasing OPG expression without affecting RANKL expression, promoting osteoblast differentiation while inhibiting osteoclast differentiation, regulating OPG expression through canonical Wnt/β-catenin signaling. | |||
T71904 |
Chlormadinone (free base)
|
||
Chlormadinone (free base) is a synthetic steroid hormone and antagonist at androgen and estrogen receptors used to treat BPH and polycystic ovary syndrome. It also promotes osteoblast differentiation and Ca deposition in bone marrow stem cells. | |||
T62436 | KY-02327 acetate | ||
KY-02327 acetate 是一种有效的 Dishevelled (Dvl)-CXXC5相互作用抑制剂,是一种代谢稳定的 KY-02061 类似物。KY-02327 acetate 能够激活 Wnt/β-catenin 途径,进而促进成骨细胞分化。 | |||
T69656 | E197 | ||
E197 is a DOCK5 inhibitor. E197 can inhibit both mouse and human osteoclast activity. In particular, E197 prevented pathological bone loss in mice. Most interestingly, treatment with E197 did not affect osteoclast and osteoblast numbers and hence did not impair bone formation. E197 could represent a lead molecule to develop new antiosteoporotic drugs targeting the mechanism of osteoclast adhesion onto the bone. | |||
T36080 |
Rivenprost
ONO-4819 |
||
Prostaglandin E2 activates four distinct G protein-coupled receptors, EP1-4. Rivenprost is a potent and selective agonist for the EP4 receptor (Ki = 0.7, 56, 620, and >10,000 nM for EP4, EP3, EP2, and EP1, respectively). It has been used to promote EP4-mediated bone formation, prevent bone loss related to osteoporosis, drive osteoblast differentiation, and stabilize bone implants.[1][2][3][4][5] Rivenprost has also been used to support wound healing.[6] | |||
T71284 |
Glimepiride urethane
|
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Glimepiride urethane is a third generation sulfonylurea compound, which increases the release of insulin from pancreatic beta cells. In addition, glimepiride increases the activity of intracellular insulin receptors. Glimepiride increases osteoblast proliferation and differentiation, which is thought to be related to its ability to activate the PI3K and Akt pathway. Furthermore, Glimepiride enhances intrinsic peroxisome proliferator-activated receptor γ activity. Glimepiride also increases prote... | |||
T75745 |
Kisspeptin-10, human TFA
|
||
Kisspeptin-10, human TFA为一种有效的血管收缩剂及血管生成抑制剂,通过其受体GPR54抑制肿瘤转移。Kisspeptin-10-GPR54系统对胚胎肾脏发展具有关键影响,而Kisspeptin-10/GPR54信号则通过NFATc4介导的BMP2表达促进成骨细胞分化。 | |||
T35604 |
Osteocalcin (1-49) (human) (trifluoroacetate salt)
|
||
Osteocalcin (1-49) is a non-collagenous peptide that is secreted by osteoblasts and odontoblasts and comprises 1-2% of the total protein in bone. Secretion of osteocalcin (1-49) is stimulated by 1,25-dihydroxy vitamin D and plasma levels increase in diseases that induce dysregulated bone turnover such as osteoporosis, Paget's disease, and primary hyperparathyroidism. Osteocalcin (1-49) is positively correlated with insulin sensitivity and negatively correlated with high blood glucose levels in w... | |||
T83848 |
VnP-16 TFA
|
||
VnP-16是一种合成肽段,对应vitronectin的氨基酸270-281,vitronectin是一种具有细胞附着、迁移和扩散等多功能作用的糖蛋白。该肽段在9.1 µg/cm2浓度下应用于细胞板时,能促进人类成骨细胞的附着和扩散,此效应可通过β1整合素的siRNA敲除被逆转。VnP-16诱导人类皮肤来源的间充质前体细胞和MC3T3-E1小鼠颅骨成骨前体细胞的成骨作用。在体内,VnP-16减少IL-1α诱导的骨质流失并减少小鼠颅骨中破骨细胞的数量。它还在卵巢切除引起的骨质疏失小鼠模型中增加骨矿物质密度并减少松质骨流失。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2771 |
Orcinol glucoside
Sakakin,苔黑酚葡萄糖苷 |
Antioxidant | oxidation-reduction |
Orcinol glucoside (Sakakin) 是一种提取自莪术中的活性成分,具有抗抑郁活性。它能诱导 MSC 转化为成骨细胞,并通过 Wnt/β-catenin 信号通路阻断脂肪形成。 | |||
TN5888 |
Toddaculin
|
Others | Others |
Toddaculin 是一种天然香豆素,抑制过度的破骨细胞活性并增强成骨细胞分化和矿化。它可诱导白血病细胞分化和凋亡,具有抗炎活性。 | |||
T13768 |
(+)-Medicarpin
|
Estrogen/progestogen Receptor | Endocrinology/Hormones |
(+)-Medicarpin, a pterocarpan, is an isoflavonoid compound derived from multiple medicinal plant species such as Sophora japonica, Zollernia paraensis, Platymiscium yucatamun, Machaerium aristulatum, and Platymiscium floribundum. It exhibits potent inhibition of osteoclastogenesis and facilitates bone healing and increased bone mass through osteoblast differentiation, which is mediated by the estrogen receptor (ER) β. | |||
T3488 |
Tectorigenin
4',5,7-Trihydroxy-6-methoxyisoflavone,Tectorigenine,鸢尾黄酮,鸢尾黄素 |
Apoptosis | Apoptosis |
Tectorigenin (4',5,7-Trihydroxy-6-methoxyisoflavone) 是一种从葛根汤干燥的花中分离出来的植物异黄酮。 | |||
TN5086 |
Syringetin
|
Others | Others |
Syringetin 是一种存在于葡萄和葡萄酒中的类黄酮衍生物,可促进 B16F10 细胞的黑色素生成,抑制人肺腺癌中成骨细胞介导的破骨细胞生成。 | |||
T3925 |
Astragaloside I
黄芪皂苷I,Cyclosieversioside B,Astrasieversianin IV |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
Astragaloside I (Cyclosieversioside B) 是从黄芪中分离得到天然产物。它可通过 Wnt/β-catenin 信号通路刺激成骨细胞分化,可用于成骨活性研究。 | |||
T2848 |
Osthole
Osthol,NSC 31868,蛇床子素,Ostol |
Apoptosis; HBV; Parasite; Histamine Receptor | Apoptosis; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience |
Osthole (Osthol) 是一种天然抗组胺药替代试剂,可刺激成骨细胞增殖和分化。它可抑制组胺 H1受体活性,还可抑制细胞培养物中 HBV 的分泌。 | |||
T6S1559 |
Aurantio-obtusin
|
Others | Others |
Aurantio-obtusin 是从决明子中分离出的蒽醌类化合物,具有抗炎、抗凝血、抗氧化、抗高血压的活性。它能抑制 IgE 介导的肥大细胞和过敏模型中的过敏反应,具有研究过敏相关疾病的潜力。在大鼠中,它通过内皮细胞 PI3K/AKT/ eNOS 依赖信号通路放松全身动脉,是潜在的新型血管扩张剂。 | |||
TN1918 |
Medicarpin
美迪紫檀素 |
Apoptosis; BCL; ROS; JNK | Apoptosis; Immunology/Inflammation; MAPK |
Medicarpin 是从紫花苜蓿中分离出的一种类黄酮。它通过调节 P-gp 介导的药物外流,诱导白血病 P388 细胞凋亡并克服多药耐药性。 | |||
T4915 |
β-Glycerophosphate disodium salt hydrate
|
Phosphatase; Endogenous Metabolite | Metabolism |
β-Glycerophosphate disodium salt hydrate 是一种磷酸酶抑制剂,是内源性代谢产物的一种。 | |||
T10109 |
3-Carene
Delta-3-Carene |
COX; Antifungal | Immunology/Inflammation; Microbiology/Virology; Neuroscience |
3-Carene(Delta-3-Carene) 是西部落叶松和花旗松中提取的双环单萜烯,可做为植物杀菌剂。3-Carene 对痛觉刺激引起的炎症浸润和 COX-2 过表达有抑制作用。3-Carene 具有抗伤害作用,能促进成骨细胞分化的早期标志物碱性磷酸酶的活性和表达。 | |||
T4S1943 |
Kirenol
奇壬醇,奇任醇,Kirel |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
Kirenol (Kirel) 是分离自 Siegesbeckia orientalis 中的,具有抗氧化、抗炎、抗过敏、抗关节炎活性,可用于缓解疼痛的研究。 | |||
TN6926 |
Paeonoside
|
Others | Others |
Paeonoside 发现与P. suffruticosa 中,具有生物活性,可以促进成骨细胞分化过程中的伤口愈合和迁移。Paeonoside 具有一定的抗糖尿病活性,可防止脓毒症和败血症引起的死亡。Paeonoside 对 MC3T3-E1细胞的前成骨细胞没有细胞毒性作用,以剂量依赖性的方式显著恢复伤口区域并促进细胞迁移和促进碱性磷酸酶(ALP)染色及其活性。 | |||
T3S2312 |
Poncirin
枸橘苷,Isosakuranetin-7-neohesperidoside |
Apoptosis; Others | Apoptosis; Others |
Poncirin (Isosakuranetin-7-neohesperidoside) 是从三叶草中分离出来的一种天然产物,具有抗炎活性。 它防止脂肪生成,增强间充质干细胞中的成骨细胞分化,增加骨矿物质密度,改善小梁微结构,可能反映 GIO 小鼠的骨形成增加和骨吸收减少。 | |||
TMA0132 | Dihydrophaseic acid | Others | Others |
Dihydrophaseic acid 3'-O-b-D-glucopyranoside (D3G) can increase the proliferation and differentiation of osteoblast cells and enhance bone formation, suggests that D3G may be a good candidate for the treatment of osteoporosis. | |||
TN1265 |
3'-O-Methylorobol
3'-O-METHYLOROBOL,3'-O-甲基香豌豆苷元 |
Others | Others |
3'-O-Methylorobol exhibits moderate antioxidant activity in the 2,2-diphenyl-1-picrylhydrazyl free radical scavenging assay, it also exerts potential analgesic properties. 3'-O-Methylorobol can increase osteoblast differentiation. | |||
TN3552 |
Byzantionoside B
|
Others | Others |
Byzantionoside B shows stimulatory activity on human osteoblast cells, it may have the potential to stimulate bone formation and regeneration. | |||
TN4594 | Murraol | Antifection | Microbiology/Virology |
Murraol shows the significant proliferative activities on osteoblast-like UMR106 cells lines at the concentration of 1 × 10-10 mol/L. It and auraptenol show 63 ug/mL MIC value against Klebsiella pneumoniae ATCC 4352 and Bacillus subtilis ATCC 9372. | |||
TN2830 | 26-Nor-8-oxo-alpha-onocerin | Others | Others |
26-Nor-8-oxo-alpha-onocerin can promote the osteoblast proliferation rate, the effect is time-dependent,concentration-dependent and differentiation state-dependent. | |||
T14368 |
Azadirachtin B
|
Others | Others |
Azadirachtin B, a limonoid derived from the seed kernels of Azadirachta indica, exhibits a broad spectrum of biochemical activities, including insecticidal, nematocidal, anticancer, anti-inflammatory, antiviral, and osteogenic effects. It is effective against the Epstein-Barr virus early antigen (EBV-EA), enhances alkaline phosphatase (ALP) activity, and promotes osteoblast differentiation[1][2][3]. | |||
TN4394 |
Kobophenol A
|
MMP; BCL; p38 MAPK; NF-κB; ROS; DNA/RNA Synthesis; CDK; JNK | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; MAPK; NF-κB; Proteases/Proteasome |
Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell death. Kobophenol A inhibits AChE activity in a dose-dependent manner, and the IC50 value is | |||
T81987 |
Kanzonol D
|
||
Kanzonol D为一种存在于Glycyrrhiza glabra的毛状根培养物中的类黄酮化合物。 | |||
TN1778 |
Isoformononetin
异刺芒柄花素,黄豆苷元杂质 |
IL Receptor; Antifection | Immunology/Inflammation; Microbiology/Virology |
Isoformononetin shows fungitoxic activity against Cladosporium sphaerospermum; it also has immunomodulatory activity, it inhibits the differentiation of Th17 cells and B-cell lymphopoesis to promote osteogenesis in estrogen-deficient bone loss conditions. |