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Search Results for " cell permeability "

74

抑制剂 & 化合物

9

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T10760	Ceramides Mixture 神经酰胺混合物,神经酰胺	Telomerase	DNA Damage/DNA Repair
	Ceramides Mixture 是表皮渗透屏障的主要脂质成分，参与生长抑制，细胞周期停滞和端粒酶活性的调节。它是一种内源性神经酰胺，由含羟基和非羟基脂肪酸的神经酰胺组成。
T8490	Butoconazole 1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole,布康唑	Antifungal	Microbiology/Virology
	Butoconazole (1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole) 是一种咪唑类抗真菌药物，可治疗白色念珠菌引起的阴道感染。它可通过抑制类固醇起抗菌作用。
T2670	ML167 NCGC00188654,CID44968231	DYRK; CDK	Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors
	ML167 (CID44968231) 是一种高选择性的 Cdc2 样激酶 4 抑制剂，IC50为 136 nM。
T2456	Tivozanib 替沃扎尼,AV-951,KRN951	VEGFR; PDGFR; Ephrin Receptor	Angiogenesis; Tyrosine Kinase/Adaptors
	Tivozanib (KRN951) 是一种选择性的 VEGFR 1/2/3抑制剂，它们的 IC50值分别为0.21 nM、0.16 nM、0.24 nM。
T18988L	FITC-Dextran (MW 4000) 荧光素异硫氰酸酯-葡聚糖,FITC-Dextran (60842-46-8 MW 4000)	Others	Others
	FITC-Dextran (MW 4000) 是一种标记物，由与 4 kDa 葡聚糖偶联的异硫氰酸荧光素组成，广泛用于微循环和细胞通透性研究。
T7486	Imeglimin hydrochloride EMD 387008 hydrochloride,(6R)-1,6-二氢-N2,N2,6-三甲基-1,3,5-三嗪-2,4-二胺盐酸盐	Reactive Oxygen Species; Mitochondrial Metabolism	Immunology/Inflammation; Metabolism; NF-κB
	Imeglimin hydrochloride (EMD 387008 hydrochloride) 是一种口服降糖剂。Imeglimin 可改善胰岛素敏感性，能够抑制活性氧的产生、增加线粒体 DNA、改善线粒体功能。
T1497	Liranaftate Piritetrate,利拉萘酯,M-732	Antifungal	Microbiology/Virology
	Liranaftate (Piritetrate) 是一种具有抗真菌活性的硫代氨基甲酸酯和角鲨烯环氧酶抑制剂，可研究皮肤癣菌。
T2213	Terconazole Gyno-Terazol,Terazol 3,Terazol 7,Triaconazole,特康唑,曲康唑,R42470	Antifection; Antifungal	Microbiology/Virology
	Terconazole (Terazol 7) 是一种广谱抗真菌药物，用于研究阴道酵母菌感染。
T15458	H2DCFDA 2',7'-二氯荧光素二乙酸酯,2',7'-Dichlorodihydrofluorescein diacetate,DCFH-DA	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	H2DCFDA (DCFH-DA) 属于绿色荧光染料，是一种检测细胞内活性氧 (ROS) 的探针 (Ex/Em=488/525 nm)，具有细胞膜渗透性。
T9646	Stafib-2	STAT	JAK/STAT signaling; Stem Cells
	Stafib-2 是一种转录因子 STAT5b 抑制剂，具有有效性和选择性。Stafib-2 对STAT5b 和 STAT5a 有抑制作用， IC50 值分别为 82 nM 和 1.7 μM。Stafib-2 的细胞通透性较差。
T6802	CFSE 5(6)-CFDA N-succinmidyl ester,Carboxyfluorescein succinimidyl ester,CFDA-SE,5(6)-羧基二乙酸荧光素琥珀酰亚胺酯,5(6)-Carboxyfluorescein diacetate succinimidyl ester	Others	Others
	CFSE (CFDA-SE) 属于荧光染料，具有细胞膜渗透性。CFSE 可在活细胞内与胞内蛋白进行不可逆的结合，用于检测细胞增殖，标记的细胞呈绿色荧光，激发波长为 488 nm，发射波长为 518 nm。
T1438	Butoconazole nitrate RS 35887,硝酸布康唑	Estrogen/progestogen Receptor; Antifungal	Endocrinology/Hormones; Microbiology/Virology
	Butoconazole nitrate (RS 35887) 是一种咪唑类抗真菌药物，可治疗由白色念珠菌引起的阴道感染。它可通过抑制类固醇合成起到抗菌作用。
T8851	I3MT-3 HMPSNE	Hippo pathway	Stem Cells
	I3MT-3 (HMPSNE) 是一种有效的、具有细胞膜渗透性的、选择性的 3-巯基丙酮酸硫转移酶 (3MST)的抑制剂，IC50值为2.7 μM，对其他硫化氢/磺胺制硫酶没有活性。它靶向位于 3MST 活性位点的过硫半胱氨酸残基。
T6961	PX-478 PX-478 2HCl	HIF/HIF Prolyl-Hydroxylase; HIF; Autophagy	Angiogenesis; Autophagy; Chromatin/Epigenetic; Metabolism
	PX-478 是一种 HIF-1α 抑制剂，具有选择性、口服活性和血脑屏障渗透性。PX-478 具有抗肿瘤活性，还可以保护糖尿病中的胰腺 β 细胞功能，用于 2 型糖尿病的研究。
T1290	Oxiconazole nitrate 硝酸奥昔康唑,Ro 13-8996	Others; Antibiotic; Antifection; Antifungal	Microbiology/Virology; Others
	Oxiconazole nitrate (Ro 13-8996) 是广谱抗真菌药物，抑制T. tonsurans 和T.rubrum 的生长，MIC90值分别为 0.25 和 0.5 μg/mL。
T6686	Sulconazole mononitrate Exelderm,Sulconazole Nitrate,RS 44872,硝酸硫康唑	Antibacterial; Antibiotic; Antifungal	Microbiology/Virology
	Sulconazole mononitrate (Exelderm) 是一种咪唑类广谱杀菌剂。它可研究皮肤真菌病，花斑糠疹病，皮肤念珠菌病。
T3934	Isavuconazonium sulfate	Antifungal	Microbiology/Virology
	Isavuconazonium sulfate 是一种口服活性抗真菌药，是活性三唑类抗真菌药物 Isavuconazole 的前药，可用于侵袭性曲霉菌病和毛霉菌病。
T7057	Methylstat	Histone Demethylase; Others	Chromatin/Epigenetic; Others
	Methylstat 是一种含有 Jumonji C 结构域的组蛋白去甲基化酶 (JMJD) 抑制剂的甲酯前药，具有良好的细胞渗透性。在体外试验中，methylstat 的游离酸可抑制 JMJD2A、JMJD2C、JMJD2E、PHF8 和 JMJD3，IC50 值分别约为 4.3、3.4、5.9、10 和 43 µM。 Methylstat 抑制 JMJD2C 敏感的食管癌细胞系 KYSE150 的生长，GI50 为 5.1 µM，而 methylstat 的游离酸在高达 100 µM 时不抑制细胞生长。 Methylstat 以浓度依赖性方式在多个位点诱导组蛋白高甲基化（KYSE150 细胞中 H3K4me3 和 H3K9me3 的 EC50 = 10.3 和 8.6 µM，MCF-7 细胞中的 EC50 分别为 6.7 和 6.3 µM）。
T63505	Tivozanib hydrochloride hydrate
	Tivozanib hydrochloride hydrate 是选择性的、有效的、口服具有活力的 VEGFR 酪氨酸激酶抑制剂，能够作用于 VEGFR-1 (IC50: 0.21 nM)、VEGFR-2 (IC50: 0.16 nM)、VEGFR-3 (IC50: 0.24 nM)。Tivozanib hydrochloride hydrate 能够抑制肿瘤组织中的血管生成和血管通透性，并具有抗肿瘤作用，对转移性肾细胞癌 (RCC) 具有研究潜力。
T6529	Halobetasol propionate 卤贝他索丙酸酯,Halobetasol Propionate,Ulobetasol propionate,BMY-30056,卤倍他索丙酸酯,CGP-14458	Phospholipase	Metabolism
	Halobetasol propionate (BMY-30056) 是一种在皮肤外使用的合成类固醇，具有抗炎，止痒和收缩血管的活性。
T3979	Emedastine LY188695,依美斯汀,Emadine	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Emedastine (LY188695) 是一种可口服的，选择性和高亲和力的组胺 H1受体拮抗剂，Ki 值为 1.3 nM。它是苯并咪唑衍生物，可用于过敏性鼻炎、过敏性皮肤疾病和过敏性结膜炎的研究。
T30307	BCN-E-BCN
	BCN-e-BCN is a new cell permeability probe for protein sulfonic acid identification.
T61446	BioA-IN-13
	BioA-IN-13 is a highly effective inhibitor of the Mycobacterium tuberculosis BioA enzyme, displaying potent cell permeability and whole-cell activity [1].
T70091	IACS-4759
	IACS-4759 is a novel potent and selective MTH1 inhibitor with excellent cell permeability and good metabolic stability in microsomes.
T71930	aPKC-I
	aPKC-I is an inhibitor of atypical protein kinase C (aPKC ) which inhibits both PKCζ and PKCι with high specificity and prevents VEGF-induced endothelial permeability in cell culture and in vivo, thereby blocking ischemia-reperfusion (IR)-induced permeability.
T21365	Butenafine KP363,KP 363,Mentax,KP-363,Butop
	Butenafine hydrochloride is a hydrochloride of butenafine, which inhibits squalene epoxidase to inhibit the synthesis of ergosterol, leading to the increased permeability of the cell membranes, allowing their contents to leak out.
T30491	BMS 183920 BMS-183920,BMS183920
	BMS-183920 is a diacid, potent angiotensin II receptor antagonist that improves Caco-2 cell permeability and in vivo oral absorption. The relative degree of hydrolysis (biological activation) and prodrug metabolism determines whether substantial improveme
T27790	Labradimil RMP-7,ALK-01-040,Receptor-mediated permeabiliser-7,DRG0182,DRG 0182,DRG-0182
	Labradimil is a bradykinin B2 receptor agonist. Labradimil increases the permeability of human brain microvascular endothelial cell monolayers. Labradimil enhances delivery of hydrophilic chemotherapeutics and increases survival in rats with metastatic tu
T24994	MreB Perturbing Compound A22 hydrochloride A22 hydrochloride,MreB Perturbing Compound A22
	A22 is an inhibitor of MreB, an actin-like bacterial protein, and has been proved to be an antibiotic adjuvant. A22 inhibition of MreB disrupts the bacterial actin cytoskeleton, which can cause an increase in cell permeability and altered transport.
T61765	Microtubule inhibitor 5
	Microtubule inhibitor 5 (compound 17f) is a highly potent cytotoxic agent that inhibits microtubule function. It exhibits a substantial cytotoxic effect on NCI-H460 cells, with an IC50 value of 154.5 nM. Moreover, this compound demonstrates excellent cell permeability [1].
T11033	DI-591	Others	Others
	DI-591 is an effective, high-affinity and cell-permeability inhibitor for DCN1-UBC12 interaction. DI-591 binds to DCN1 and DCN2 with Ki values of 12 and nM and 10.4 nM, respectively, and has no obvious binding to DCN3, DCN4 and DCN5 proteins.
T61715	RmlA-IN-1
	RmlA-IN-1 (Compound 8a) is a highly potent inhibitor of glucose-1-phosphate thymidylyltransferase (RmlA), with an IC50 value of 0.073 μM. It significantly modulates the biosynthesis of monosaccharide l-Rhamnose and impacts the permeability of the bacterial cell wall [1].
TP1610	Secretin, canine
	Secretin is an endocrine hormone that stimulates the secretion of bicarbonate-rich pancreatic fluids. Canine secretin can regulates gastric chief cell function and paracellular permeability in canine gastric monolayers by a Src kinase-dependent pathway.
T79463	Antitumor agent-110	Apoptosis	Apoptosis
	Antitumor agent-110 (compound 13) 是一种抗癌咪唑四嗪，具备良好的渗透性，能够阻滞细胞周期于G2/M期并诱导apoptosis。
T78976	Antibacterial agent 141
	Antibacterialagent 141（Compound B14）针对四种植物病原体Xoo、Xac、Psa与Cmm展现出了抗菌效果，其EC50值为1.28 μM。该化合物能够抑制细胞膜形成并改变细胞透性。
T74391	OARV-771
	OARV-771 是一种基于 VHL 的 BET 降解剂 (PROTAC)，具有改善的细胞通透性。OARV-771 显示 Brd4、Brd2 和 Brd3的 DC50分别为 6、1 和 4 nM。
T62471	SGC agonist 1
	SGC agonist 1 是一种有效的可溶性鸟苷酸环化酶 (SGC) 激动剂。SGC agonist 1 能够提高溶解度并具有高细胞通透性。SGC agonist 1 具有潜力进行心血管疾病的研究。
T73490	MU1700
	MU1700 是一种具有口服活性的、强效的 ALK1/2抑制剂，IC50分别为 13 nM 和 6 nM，其具有细胞膜通透性以及高脑渗透性。
T83069	Antifungal agent 75
	Antifungalagent 75 (compound 6r) 是针对白色念珠菌有效的抗真菌剂。该化合物通过显著抑制生物膜形成、增加细胞膜通透性、降低麦角甾醇水平并破坏膜结构，从而破坏细胞结构完整性，发挥其抗真菌活性。
T79298	Antifungal agent 61
	Antifungalagent 61 (Compound 38)是一种有效的抗真菌剂，其对V. mali的EC50值为0.50 mg/L。该化合物通过诱导细胞畸变和收缩、减少线粒体数量、增厚细胞壁和提高细胞膜透性来实现其抑制作用。
T63779	RmlA-IN-2
	RmlA-IN-2 是 1-磷酸葡萄糖胸苷转移酶 (RmlA) 的有效抑制剂 (IC50: 0.303 μM)。RmlA-IN-2 能够影响单糖 l-鼠李糖生物合成途径，并影响细菌细胞壁通透性。
T72752	MNK inhibitor 9
	MNK inhibitor9 是一种有效的选择性的 MNK1/2抑制剂，IC50值分别为 0.003 µM 和 0.003 µM。MNK inhibitor9 具有良好的细胞渗透性。MNK inhibitor9 可用于肿瘤相关研究。
T79411	hCAXII-IN-7	Carbonic Anhydrase	Metabolism
	hCAXII-IN-7 (compound 6e)为hCA XII抑制剂，且具备脑屏障通透性。此化合物能够诱导786-0、SF-539和HS 578 T细胞系的凋亡。
T74281	FAK PROTAC B5
	FAKPROTACB5 (Compound B5) 是FAKPROTAC 降解剂，IC50值为14.9 nM。FAKPROTACB5 具有很强的FAK 降解活性，抗增殖活性，血浆稳定性。FAKPROTACB5 抑制细胞迁移与侵袭。
T80215	BMAP-28	Antibiotic	Microbiology/Virology
	BMAP-28为一种抗生肽兼具线粒体透性转换孔(inducing agent)功能，能够触发线粒体的透性转换孔(opening)，进而诱导细胞凋亡。该化合物在微生物感染及癌症研究领域具有潜在应用价值。
T72137	Mitochondrial respiration-IN-3
	Mitochondrial respiration-IN-3 是 Dalfopristin 的氟衍生物。Mitochondrial respiration-IN-3 具有细胞膜渗透性。Mitochondrial respiration-IN-3 可以抑制胶质母细胞瘤干细胞的线粒体翻译 (mitochondrial translation)。Mitochondrial respiration-IN-3 可用于癌症的研究
T76543	NoxaBH3
	NoxaBH3，一种基于半胱氨酸的交联肽，具备提高的细胞渗透性及较高对Mcl-1的抑制效能。该化合物通过与CXCR4的内源性配体结合，形成泛素-NoxaBH3偶联物，进而被导向癌细胞。
T82089	ICMT-IN-53
	ICMT-IN-53 (compound 12)是ICMT抑制剂，IC50值为0.96 μM，展现出PAMPA渗透性及抗增殖效果。该化合物在抑制MDA-MB-231与PC3细胞增殖方面的IC50s分别为5.14 μM与5.88 μM。
T78777	Vem-L-Cy5	Raf	MAPK
	Vem-L-Cy5 (化合物3)是一款改造自Vemurafenib的BRAF抑制剂, 其结构通过近红外荧光团Cy5进行修饰。该化合物针对BRAFV600E具有特异性，并能有效阻断MEK的磷酸化作用。Vem-L-Cy5展现了良好的细胞内渗透能力，并能抑制多种癌细胞系的生长。
T74779	JNJ-28583113
	JNJ-28583113 是一种具有脑透性的 TRPM2拮抗剂。JNJ-28583113 抑制 TRPM2 阻断 GSK3α和β亚基的磷酸化。JNJ-28583113 保护细胞免受氧化应激诱导的细胞死亡。JNJ-28583113 还抑制小胶质细胞响应促炎刺激而释放细胞因子。

化合物

Ceramides Mixture

Cat.No: T10760

Synonym: 神经酰胺混合物,神经酰胺

Target: Telomerase

Cat.No: T8490

Synonym: 1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole,布康唑

Target: Antifungal

Cat.No: T2670

Synonym: NCGC00188654,CID44968231

Target: DYRK, CDK

Cat.No: T2456

Synonym: 替沃扎尼,AV-951,KRN951

Target: VEGFR, PDGFR, Ephrin Receptor

FITC-Dextran (MW 4000)

Cat.No: T18988L

Synonym: 荧光素异硫氰酸酯-葡聚糖,FITC-Dextran (60842-46-8 MW 4000)

Target: Others

Imeglimin hydrochloride

Cat.No: T7486

Synonym: EMD 387008 hydrochloride,(6R)-1,6-二氢-N2,N2,6-三甲基-1,3,5-三嗪-2,4-二胺盐酸盐

Target: Reactive Oxygen Species, Mitochondrial Metabolism

Cat.No: T1497

Synonym: Piritetrate,利拉萘酯,M-732

Target: Antifungal

Cat.No: T2213

Synonym: Gyno-Terazol,Terazol 3,Terazol 7,Triaconazole,特康唑,曲康唑,R42470

Target: Antifection, Antifungal

Cat.No: T15458

Synonym: 2',7'-二氯荧光素二乙酸酯,2',7'-Dichlorodihydrofluorescein diacetate,DCFH-DA

Target: Reactive Oxygen Species

Cat.No: T9646

Target: STAT

Cat.No: T6802

Synonym: 5(6)-CFDA N-succinmidyl ester,Carboxyfluorescein succinimidyl ester,CFDA-SE,5(6)-羧基二乙酸荧光素琥珀酰亚胺酯,5(6)-Carboxyfluorescein diacetate succinimidyl ester

Target: Others

Butoconazole nitrate

Cat.No: T1438

Synonym: RS 35887,硝酸布康唑

Target: Estrogen/progestogen Receptor, Antifungal

Cat.No: T8851

Synonym: HMPSNE

Target: Hippo pathway

Cat.No: T6961

Synonym: PX-478 2HCl

Target: HIF/HIF Prolyl-Hydroxylase, HIF, Autophagy

Oxiconazole nitrate

Cat.No: T1290

Synonym: 硝酸奥昔康唑,Ro 13-8996

Target: Others, Antibiotic, Antifection, Antifungal

Sulconazole mononitrate

Cat.No: T6686

Synonym: Exelderm,Sulconazole Nitrate,RS 44872,硝酸硫康唑

Target: Antibacterial, Antibiotic, Antifungal

Isavuconazonium sulfate

Cat.No: T3934

Target: Antifungal

Cat.No: T7057

Target: Histone Demethylase, Others

Tivozanib hydrochloride hydrate

Cat.No: T63505

Halobetasol propionate

Cat.No: T6529

Synonym: 卤贝他索丙酸酯,Halobetasol Propionate,Ulobetasol propionate,BMY-30056,卤倍他索丙酸酯,CGP-14458

Target: Phospholipase

Cat.No: T3979

Synonym: LY188695,依美斯汀,Emadine

Target: Histamine Receptor

Cat.No: T30307

Cat.No: T61446

Cat.No: T70091

Cat.No: T71930

Cat.No: T21365

Synonym: KP363,KP 363,Mentax,KP-363,Butop

Cat.No: T30491

Synonym: BMS-183920,BMS183920

Cat.No: T27790

Synonym: RMP-7,ALK-01-040,Receptor-mediated permeabiliser-7,DRG0182,DRG 0182,DRG-0182

MreB Perturbing Compound A22 hydrochloride

Cat.No: T24994

Synonym: A22 hydrochloride,MreB Perturbing Compound A22

Microtubule inhibitor 5

Cat.No: T61765

Cat.No: T11033

Target: Others

Cat.No: T61715

Secretin, canine

Cat.No: TP1610

Antitumor agent-110

Cat.No: T79463

Target: Apoptosis

Antibacterial agent 141

Cat.No: T78976

Cat.No: T74391

Cat.No: T62471

Cat.No: T73490

Antifungal agent 75

Cat.No: T83069

Antifungal agent 61

Cat.No: T79298

Cat.No: T63779

MNK inhibitor 9

Cat.No: T72752

Cat.No: T79411

Target: Carbonic Anhydrase

Cat.No: T74281

Cat.No: T80215

Target: Antibiotic

Mitochondrial respiration-IN-3

Cat.No: T72137

Cat.No: T76543

Cat.No: T82089

Cat.No: T78777

Target: Raf

Cat.No: T74779

Cat. No.	Product Name	Target	Signaling Pathways
T2721	Digitonin	Others	Others
	Digitonin 属于糖苷类天然产物，是一种去垢剂。Digitonin 具有抗肿瘤活性，可以与胆固醇分子结合从而增加细胞膜的通透性，对多种细胞的细胞膜具有裂解活性。
TF0083	POPE
	POPE 是从大肠杆菌中发现的化合物，是细胞膜的一部分，可用来研究改变细胞膜通透性。
TN1990	Norathyriol 芒果苷元	Akt; DNA/RNA Synthesis; AMPK; PPAR	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling
	Norathyriol 是来自芒果的芒果苷代谢物，具有抗氧化、抗癌、抗菌和抗炎活性。它以非竞争性方式抑制 α-葡萄糖苷酶，IC50为 3.12 μM。它还抑制PPARα、PPARβ和PPARγ，IC50分别为 92.8、102.4 和 153.5 µM。
T0146	Tioconazole UK-20349,Vagistat,噻康唑	Antibiotic; Antifection; Antifungal	Microbiology/Virology
	Tioconazole (Vagistat) 是一种广谱性的抗真菌咪唑衍生物。它抑制几种皮肤真菌和几种酵母菌的 MIC50分别小于 3.12 mg/L 和 9 mg/L。
T8641	Vancomycin	Antibacterial; Antibiotic; Autophagy	Autophagy; Microbiology/Virology
	Vancomycin 是一种糖肽类抗生素，可以通过改变细胞膜的渗透性并选择性地抑制核糖核酸的合成以发挥抗菌活性。Vancomycin 可以用于治疗所有抗生素均无效的严重感染。
TN2160	Roemerine (-)-Roemerine	Antibiotic	Microbiology/Virology
	Roemerine ((-)-Roemerine) 是一种来自塞内加尔番荔枝的卟啉生物碱，具有抗真菌和抗癌活性，通过抑制 Bmr 来防止小檗碱外排。Roemerine 以浓度依赖性方式增加细胞膜通透性，可用于研究真菌感染和前列腺癌。
TN6198	Mahanine
	Mahanine has effects on the activation of the apoptotic pathway in human leukemia U937 cells, causes the mitochondrial membranes to lose their permeability, resulting in caspase-3 activation and apoptosis. Mahanine can reverse an epigenetically silenced g
TN2945	3-Hydroxybakuchiol	ATPase; Caspase	Apoptosis; Membrane transporter/Ion channel; Proteases/Proteasome
	3-Hydroxybakuchiol exerts cytotoxic and anti-proliferative effects on the TA3/Ha mouse mammary adenocarcinoma cell line and induces a decrease in the mitochondrial transmembrane potential, the activation of caspase-3, the opening of the mitochondrial perm
T37810	6',7'-Epoxybergamottin
	6'7'-Epoxybergamottin is a furanocoumarin found in grapefruit. It is a potent inhibitor of the cytochrome P450 (CYP) isoform CYP3A4 with an IC50 value of 0.30 ppm in a cell-free assay, 0.33 μM in HL7 human liver cells, and 0.22 μM in S9 human intestine cells. It has been studied in the context of drug interactions with grapefruit constituents. It is found in grapefruit juice at concentrations of 0.1-7.4 μM and inhibits the transport of talinolol , a permeability glycoprotein (P-gp/ABCB1) transpo...

天然产物

Cat.No: T2721

Target: Others

Cat.No: TF0083

Cat.No: TN1990

Synonym: 芒果苷元

Target: Akt, DNA/RNA Synthesis, AMPK, PPAR

Cat.No: T0146

Synonym: UK-20349,Vagistat,噻康唑

Target: Antibiotic, Antifection, Antifungal

Cat.No: T8641

Target: Antibacterial, Antibiotic, Autophagy

Cat.No: TN2160

Synonym: (-)-Roemerine

Target: Antibiotic

Cat.No: TN6198

3-Hydroxybakuchiol

Cat.No: TN2945

Target: ATPase, Caspase

6',7'-Epoxybergamottin

Cat.No: T37810

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