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Search Results for " anticancer effect "

24

抑制剂 & 化合物

19

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9805	BAY 2666605	PDE	Metabolism
	BAY 2666605 是一种具有口服活性的 PDE3A 和 PDE3B 抑制剂，IC50 分别为 87 nM 和 50 nM。 BAY 2666605 具有抗癌作用。
T24730	Roslin 2 bromide Roslin-2,Benzylhexamethylenetetramine bromide,Roslin2	FAK; p53	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Roslin 2 bromide (Benzylhexamethylenetetramine bromide) 是一种 p53 再激活剂，可破坏 FAK 和 p53 的结合。 Roslin 2 bromide 具有抗癌作用。
T1801	SR9243	Liver X Receptor	Metabolism
	SR9243 是一种 liver-X-receptor 的反向激动剂，可诱导 LXR-辅阻遏物相互作用。
T36646	Trastuzumab deruxtecan DS-8201a,VRN-101099,DS 8201,T-DXd	Others	Others
	Trastuzumab deruxtecan (T-DXd) 是一种具有抗癌抗肿瘤活性的抗体-活性分子偶联物 (ADC)。Trastuzumab deruxtecan 对 HER2 阳性乳腺癌和胃癌有改善作用。
T72064	TASK-1-IN-1	Potassium Channel	Membrane transporter/Ion channel
	TASK-1-IN-1 是一种有效的选择性的 TASK-1 (Potassium Channel) 抑制剂（IC50 ： 148 nM）。TASK-1-IN-1 对 TASK-3 通道的IC50 为 1750 nM，抑制作用有所降低。TASK-1-IN-1 具有抗癌作用。
T71703L	Isomer-Turosteride Isomer-Turosteride(Isomer-137099-09-3)	Reductase	Endocrinology/Hormones; Metabolism
	Isomer-Turosteride (Isomer-Turosteride(Isomer-137099-09-3)) 是一种新型 5α- 还原酶抑制剂。Isomer-Turosteride 在成年大鼠中的抗前列腺作用与抑制T向 DHT 的转化有关。Isomer-Turosteride引起前列腺 DHT 的降低，与 T 含量的继发性增加无关。Isomer-Turosteride 具有抗癌活性，可抑制肿瘤细胞的生长。
T26285	TPMP-I-2 TPMP-I 2,TPMP-I2
	TPMP-I-2 has an anticancer effect of immunotoxins.
T62124	Anticancer agent 80
	Anticancer agent 80 (Compound 3c) 是一种抗癌剂。Anticancer agent 80 对 T47-D 表现出明显的暗毒性作用 (IC50: 10.14 μM)。
T15262	Vactosertib Hydrochloride TEW-7197 Hydrochloride,EW-7197 Hydrochloride	ALK	Angiogenesis; Tyrosine Kinase/Adaptors
	Vactosertib Hydrochloride is an orally active and ATP-competitive ALK5 inhibitor (IC50: 12.9 nM). It has potently antimetastatic activity and anticancer effect. Vactosertib Hydrochloride also inhibits ALK2 and ALK4 (IC50: 17.3 nM).
T63599	Anticancer agent 54
	Anticancer agent 54 是有效的抗癌剂，其抗癌活性取决于 DNA 嵌入和 ROS 生成。 Anticancer agent 54 能够将细胞周期阻滞在 G0/G1 期，并诱导细胞凋亡 (apoptosis)，具有抗增殖效果。
T63671	Anticancer agent 60
	Anticancer agent 60 对人 HepG2 细胞具有抗增殖效果，其 IC50 值为 4.13 μM。在人 HepG2 异种移植小鼠模型中，Anticancer agent 60 表现出抗肿瘤活性。
T61728	MY-875
	MY-875 is a potent microtubulin polymerization inhibitor that competes at colchicine binding sites, exhibiting an IC50 value of 0.92 μM. It effectively suppresses microtubulin polymerization, exerting its inhibitory effect. Additionally, MY-875 exerts its biological impact by activating the Hippo pathway, inducing apoptosis, and displaying commendable anticancer activity [1].
T78016	Angiopep-2 hydrochloride
	Angiopep-2 hydrochloride为脑肽载体，其与抗肿瘤活性分子结合能够增强后者在脑癌治疗中的效能。
T63932	BCR-ABL-IN-4
	BCR-ABL-IN-4 是 BCR-ABLL 抑制剂，表现出抗癌活性。BCR-ABL-IN-4 对癌细胞生长具有抑制作用，能够作用于 K562 细胞 (IC50: 0.67 nM) 和 BCR-ABL T315I 转染的 Ba/F3 细胞 (IC50: 16 nM)。
T78768	HDAC6-IN-16	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	HDAC6-IN-16（compound 5c）是基于Quinazolin-4(3H)-One的一种HDAC6抑制剂，具备抑制肿瘤细胞集落形成的抗癌活性。该化合物能够引发G2期细胞周期阻滞并诱导细胞凋亡(apoptosis)。
T60731	Mitobronitol
	Mitobronitol (Myelobromol; DBM) 是甘露醇的溴化类似物。Mitobronitol 是被归类为烷化剂的抗癌剂。Mitobronitol 具有骨髓抑制作用，可显著降低加速慢性粒细胞白血病异体骨髓移植的几种并发症的风险。
T62521	A2AAR/HDAC-IN-1
	A2AAR/HDAC-IN-1 (compound 14c) 是一种口服具有活力的、平衡的 A2AAR/HDAC 双抑制剂，作用于 A2AAR (Ki: 163.5 nM)、HDAC1 (IC50: 145.3 nM)。A2AAR/HDAC-IN-1 具有抗癌 (anticancer) 效果。
T63823	K20
	K20 是有效的、选择性的 KRas G12C 抑制剂 (IC50: 1.16 nM)。在 H358 细胞中，K20 具有抗癌作用，其 IC50 值为 0.78 μM。K20 能够抑制 NCI-H358 肿瘤细胞生长 (TGI: 41%)，且没有明显毒性。K20 能够减少 Erk 的磷酸化水平，可导致癌细胞凋亡 (apoptosis)。
T71361	CHS-828 nicotinate
	CHS-828 nicotinate is a CHS-828 salt with Nicotinic acid.. CHS-828 also known as GMX-1778, is a potent and selective NAMPT inhibitor. CHS-828 inhibits cellular synthesis of NAD. CHS 828 kill tumour cells by inhibiting the nuclear factor-kappaB translocation but unlikely through down-regulation of proteasome. CHS 828 has shown promising anticancer activity in experimental tumor models and primary cultures of cancer cells from patients. CHS 828 showed a synergistic effect with melphalan in 67%, ...
T73255	Akt1-IN-1
	Akt1-IN-1 是一种有效的 Akt1抑制剂，对 MIA Paca-2 细胞的 IC50为 18.79 nM。Akt1-IN-1 不具有明显的致畸性、肝毒性和心脏毒性 (有害作用剂量大于 100 µM)。Akt1-IN-1 可用于抗癌研究。
T61961	Pyruvate Carboxylase-IN-2
	Pyruvate Carboxylase-IN-2 是毛兰素的天然类似物。Pyruvate Carboxylase-IN-2 (compound 29) 是有效的丙酮酸羧化酶(pyruvate carboxylase) 抑制剂。在基于细胞裂解物和基于细胞的 PC 活性中，Pyruvate Carboxylase-IN-2的 IC50s 分别为 0.065 和 0.097 μM。Pyruvate Carboxylase-IN-2介导人肝细胞癌 (HCC) 的抗癌作用。
T78608	Anticancer agent 164	Apoptosis	Apoptosis
	CML-IN-1（compound 7）是一种高效抗癌药物，针对人类慢性粒细胞白血病（CML）细胞系K562，能有效诱导凋亡（apoptosis）。该化合物主要通过显著抑制PI3K/Akt信号通路的蛋白磷酸化来发挥作用，同时CML-IN-1（compound 4）也能通过抑制结直肠癌的MEK/ERK信号通路来阻止细胞增殖。
T79322	Antiproliferative agent-30
	Antiproliferative agent-30 (Compound 8g) 抑制微管蛋白组装且可抑制FLT3及Abl1。该化合物展现出对血管的破坏活性，并对多种癌细胞系表现出强效的抗增殖能力，包括HCT-116、K562及MV-4-11细胞（IC50值分别为0.054 nM、0.008 nM、0.144 nM）。此外，Antiproliferative agent-30 亦对携带FLT3-ITD-TKD突变的AML显示出抗癌效果。
T36844	Inostamycin A
	Inostamycin A is a bacterial metabolite that has been found inStreptomycesand has anticancer activity.1It is an inhibitor of CDP-diacylglycerol:inositol 3-phosphatidyltransferase (IC50= 0.02 μg/ml in A431 cell membranes) and is selective for CDP-diacylglycerol:inositol 3-phosphatidyltransferase over phospholipase C (PLC) and phosphatidylinositol kinase at 10 μg/ml.2Inostamycin A decreases viability of YCU-T892, KCC-TC873, KB, HSC-4, and YCU-T891 oral squamous cell carcinoma (OSCC) cells in a con...

化合物

Cat.No: T9805

Target: PDE

Roslin 2 bromide

Cat.No: T24730

Synonym: Roslin-2,Benzylhexamethylenetetramine bromide,Roslin2

Target: FAK, p53

Cat.No: T1801

Target: Liver X Receptor

Trastuzumab deruxtecan

Cat.No: T36646

Synonym: DS-8201a,VRN-101099,DS 8201,T-DXd

Target: Others

Cat.No: T72064

Target: Potassium Channel

Isomer-Turosteride

Cat.No: T71703L

Synonym: Isomer-Turosteride(Isomer-137099-09-3)

Target: Reductase

Cat.No: T26285

Synonym: TPMP-I 2,TPMP-I2

Anticancer agent 80

Cat.No: T62124

Vactosertib Hydrochloride

Cat.No: T15262

Synonym: TEW-7197 Hydrochloride,EW-7197 Hydrochloride

Target: ALK

Anticancer agent 54

Cat.No: T63599

Anticancer agent 60

Cat.No: T63671

Cat.No: T61728

Angiopep-2 hydrochloride

Cat.No: T78016

Cat.No: T63932

Cat.No: T78768

Target: HDAC

Cat.No: T60731

A2AAR/HDAC-IN-1

Cat.No: T62521

Cat.No: T63823

CHS-828 nicotinate

Cat.No: T71361

Cat.No: T73255

Pyruvate Carboxylase-IN-2

Cat.No: T61961

Anticancer agent 164

Cat.No: T78608

Target: Apoptosis

Antiproliferative agent-30

Cat.No: T79322

Cat.No: T36844

Cat. No.	Product Name	Target	Signaling Pathways
TN7060	Methyl oleanonate	PPAR	DNA Damage/DNA Repair; Metabolism
	Methyl oleanonate 是从柃木中分离得到的一种三萜类天然产物，是齐墩果酸衍生物，是一种PPARγ激动剂，具有抗癌作用。
T3S1196	mogroside IV	Others	Others
	Mogroside IV 是一种从罗汉果提取物中分离得到的三萜糖苷。它是非糖类甜味剂，甜度比蔗糖高。它具有抗氧化，抗糖尿病和抗癌作用。
T10390	Asperphenamate	Others; Antifungal	Microbiology/Virology; Others
	Asperphenamate 是 Aspergillus flatiipes 的真菌代谢产物。 T47D 细胞、MDA-MB-231 细胞和 HL-60 细胞的 IC50 分别为 92.3 μM、96.5 μM 和 97.9 μM。 Asperphenamate 具有抗癌作用。
T7441	Cuminaldehyde Cuminic aldehyde,4-异丙基苯甲醛,Cuminal	Endogenous Metabolite	Metabolism
	Cuminaldehyde (Cuminal) 是一种具有抑制 α-突触核蛋白纤颤和细胞毒性作用的天然醛，是一种 Cuminum cyminum 的主要成分。它显示抗癌特性。
T5724	Neogambogic acid neo-gambogic acid,新藤黄酸	Apoptosis; Others; Antibacterial	Apoptosis; Microbiology/Virology; Others
	Neogambogic acid 是藤黄的有效成分，可诱导细胞凋亡并具有抗癌作用。它有效抑制耐甲氧西林的金黄色葡萄球菌。
TN1727	Helichrysetin 4,2',4'-三羟基-6'-甲氧基查耳酮,蜡菊亭	Apoptosis; HIV Protease	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Helichrysetin 是从豆蔻果实中分离出的一种天然产物，是一种 DNA 结合抑制剂，可抑制原位导管癌DCIS 的形成。它抑制细胞生长，可诱导 A549 细胞凋亡。
T5S1285	(+)-(3R,8S)-Falcarindiol Falcarindiol,镰叶芹二醇	Others	Others
	(+)-(3R,8S)-Falcarindiol 是一种从胡萝卜中得到的聚乙炔，有抗炎、抗肿瘤和抗脂质过氧化活性。它具有抗分歧杆菌作用，对Mycobacterium tuberculosisH37Ra 的 MIC 和 IC50值分别为 24 μM 和 6 μM。
T3339	Sophoridine 5-Epidihydrosophocarpine,槐定碱,Dihydro-5-episophocarpine	Apoptosis; Topoisomerase	Apoptosis; DNA Damage/DNA Repair
	Sophoridine (Dihydro-5-episophocarpine) 是一种从豆科植物槐豆斜生植物的叶子中分离出来的喹喔啉生物碱。它是胰腺癌的候选药物，诱导细胞凋亡。
T3S0081	Oxypeucedanin (+-)-Oxypeucedanin,氧化前胡素,Oxypeucadanin	Potassium Channel	Membrane transporter/Ion channel
	Oxypeucedanin ((+-)-Oxypeucedanin) 是呋喃香豆素衍生物，分离自Angelica dahurica。它是选择性开放通道阻滞剂，可抑制hKv1.5通道电流，IC50值为 76 nM。它延长心脏动作电位持续时间，是潜在的抗心律失常试剂。它通过抑制癌细胞迁移来诱导细胞凋亡。
T3398	Icaritin Anhydroicaritin,去水淫羊藿黄素,Cycloicaritin	Apoptosis; JAK; STAT; Autophagy	Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	Icaritin (Anhydroicaritin) 是Epimedium Genusis 的异戊二烯类黄酮衍生物，有效抑制 K562 细胞和原代 CML 细胞的增殖。它可以调节MAPK/ERK/JNK 和JAK2/STAT3/AKT 信号传导，并具有增强成骨的作用。
T3895	Polyphyllin I 重楼皂苷I,重楼皂甙	Apoptosis; Akt; JNK; PDK; mTOR; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
	Polyphyllin I 是从七叶一枝花中提取的生物活性成分，具有很强的抗肿瘤活性。它是 JNK 信号通路的激活剂，也是 PDK1/Akt/mTOR 信号传导的抑制剂。它诱导自噬，G2/M 期阻滞和细胞凋亡。
T3824	Jaceosidin	Apoptosis; BCL; COX; UGT	Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience
	Jaceosidin 是从毛莲蒿中得到的一种黄酮类天然产物，可激活Bax，下调 Mcl-1 和 c-FLIP 的表达，诱导癌细胞凋亡。它能够降低炎性因子水平，激活 NF-κB，抑制COX-2的表达，具有抗癌和抗炎作用。
T2S1865	Octyl gallate Gallic acid octyl ester,n-Octylgallate,Octyl 3,4,5-trihydroxybenzoate,Progallin O,Stabilizer GA-8,没食子酸辛酯	Antioxidant; Influenza Virus; Reactive Oxygen Species; Antibacterial; Antifungal; HSV	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; oxidation-reduction
	Octyl gallate (Octyl 3,4,5-trihydroxybenzoate) 具有抗菌、抗氧化作用，有选择性和敏感性的荧光特性，广泛用作食品添加剂。它对 HSV-1，水泡性口炎病毒和脊髓灰质炎病毒有显著的抗病毒作用。
T1033L	Monensin Elancoban,Rumensin,莫能菌素
	Monensin is an antiprotozoal agent produced by Streptomyces cinnamonensis. It has an inhibitory effect on the Wnt/β-catenin signaling cascade. Monensin is a prospective anticancer drug for the therapy of neoplasia with deregulated Wnt signaling.
TN4695	Odorine	Others	Others
	Odorine has potent anti-carcinogenic effect by inhibiting both the initiation and promotion stages of two-stage skin carcinogenesis. It was found to inhibit the growth of the vinblastine-resistant KB cells by enhancing the anticancer activity of vinblastine.
TMA0424	Martynoside	ROS	Immunology/Inflammation
	Martynoside is a natural selective estrogen receptor modulator, which has antioxidative, anti-muscle fatigue, anticancer and antimetastatic activities. Martynoside has the potential of antagonizing sports anaemia, the mechanism of this effect might be rel
TN5264	Xanthoxyletin	TNF; NOS; ROS; COX; Antifection	Apoptosis; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Xanthoxyletin shows potent antibacterial, fungicidal, and algicidal properties, it also has anticancer, and anti-inflammatory activities. It shows an inhibitory effect on iNOS protein expression at 10 microM, it also can inhibit the synthesis of nitric oxide and the protein expression of tumor necrosis factor-alpha and cyclooxygenase-2. Xanthoxyletin induces S phase arrest and apoptosis in human gastric adenocarcinoma SGC-7901 cells, the effects are associated with the DNA damage, apoptosis thro...
TN5243	Vitexilactone	NADPH-oxidase; HIV Protease; Antifection	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Vitexilactone is a HIV-1 reverse transcriptase inhibitor in virtual screening against Indonesian Herbal Database using AutoDock4 performed on HIV-1 reverse transcriptase. It has trypanocidal activity, the minimum lethal concentration against epimastigotes
TN4223	Homopterocarpin	Antifection	Microbiology/Virology
	Homopterocarpin and Pterocarpus extract offer gastroprotection against indomethacin- induced ulcer by antioxidative mechanism and the modulation of gastric homeostasis, homopterocarpin may be responsible for, or contribute to the antiulcerogenic property

天然产物

Methyl oleanonate

Cat.No: TN7060

Target: PPAR

Cat.No: T3S1196

Target: Others

Cat.No: T10390

Target: Others, Antifungal

Cat.No: T7441

Synonym: Cuminic aldehyde,4-异丙基苯甲醛,Cuminal

Target: Endogenous Metabolite

Neogambogic acid

Cat.No: T5724

Synonym: neo-gambogic acid,新藤黄酸

Target: Apoptosis, Others, Antibacterial

Cat.No: TN1727

Synonym: 4,2',4'-三羟基-6'-甲氧基查耳酮,蜡菊亭

Target: Apoptosis, HIV Protease

(+)-(3R,8S)-Falcarindiol

Cat.No: T5S1285

Synonym: Falcarindiol,镰叶芹二醇

Target: Others

Cat.No: T3339

Synonym: 5-Epidihydrosophocarpine,槐定碱,Dihydro-5-episophocarpine

Target: Apoptosis, Topoisomerase

Cat.No: T3S0081

Synonym: (+-)-Oxypeucedanin,氧化前胡素,Oxypeucadanin

Target: Potassium Channel

Cat.No: T3398

Synonym: Anhydroicaritin,去水淫羊藿黄素,Cycloicaritin

Target: Apoptosis, JAK, STAT, Autophagy

Cat.No: T3895

Synonym: 重楼皂苷I,重楼皂甙

Target: Apoptosis, Akt, JNK, PDK, mTOR, Autophagy

Cat.No: T3824

Target: Apoptosis, BCL, COX, UGT

Cat.No: T2S1865

Synonym: Gallic acid octyl ester,n-Octylgallate,Octyl 3,4,5-trihydroxybenzoate,Progallin O,Stabilizer GA-8,没食子酸辛酯

Target: Antioxidant, Influenza Virus, Reactive Oxygen Species, Antibacterial, Antifungal, HSV

Cat.No: T1033L

Synonym: Elancoban,Rumensin,莫能菌素

Cat.No: TN4695

Target: Others

Cat.No: TMA0424

Target: ROS

Cat.No: TN5264

Target: TNF, NOS, ROS, COX, Antifection

Cat.No: TN5243

Target: NADPH-oxidase, HIV Protease, Antifection

Homopterocarpin

Cat.No: TN4223

Target: Antifection

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