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Search Results for " yes "

Targets Recommended: Others YAP

23

抑制剂 & 化合物

4

天然产物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T9053	Lats-IN-1	Others; YAP	Others; Stem Cells
	Lats-IN-1 是一种 ATP 竞争性的、高效的Lats1和Lats2激酶抑制剂，能促进有丝分裂后哺乳动物组织的 Yap 依赖性增殖。
T9954	K-975	Others	Others
	K-975是一种高选择性的具有口服活性的TEAD 抑制剂，可有效抑制TEAD 和YAP1/TAZ 之间的蛋白质-蛋白质相互作用。
T3112	Verteporfin 维替泊芬,BPD-MA,CL 318952	Apoptosis; YAP; VDA; Autophagy	Angiogenesis; Apoptosis; Autophagy; Stem Cells
	Verteporfin (BPD-MA) 是一种 YAP 抑制，抑制 YAP-TEAD 相互作用。Verteporfin 也是一种光敏剂，用于光动力疗法。Verteporfin 还可以诱导细胞凋亡，抑制自噬。
T8421	TED-347	YAP	Stem Cells
	TED-347 是不可逆的、共价的 YAP-TEAD 蛋白质-蛋白质相互作用变构抑制剂，对 TEAD4•Yap1 蛋白质-蛋白质相互作用的 EC50为 5.9 μM。它与 TEAD4 中央口袋内的 Cys-367 特异性共价结合(Ki:10.3 μM)。它可以抑制 TEAD 的转录活性，并且具有抗肿瘤作用。
T3050	ML-7 hydrochloride ML-7 HCl,ML-7盐酸盐	Serine/threonin kinase; Myosin; YAP; PKA; PKC	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism; Stem Cells; Tyrosine Kinase/Adaptors
	ML-7 hydrochloride (ML-7 HCl) 是一种可渗透细胞的、可逆的、有效的、ATP 竞争性的肌球蛋白轻链激酶(MLCK) 特异性抑制剂，IC50为300 nM。它还抑制平滑肌肌球蛋白轻链激酶、PKA 和 PKC。
T1477	AICAR NSC105823,AICA Riboside,Acadesine,阿卡地新,AICAR (Acadesine)	Mitophagy; YAP; AMPK; Autophagy	Autophagy; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling; Stem Cells
	AICAR (NSC105823) 是一种腺苷类似物，是一种 AMP 激活的蛋白激酶激活剂，可用于治疗急性淋巴细胞白血病和糖尿病。
T22372	MYF-01-37 1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one	Others; YAP	Others; Stem Cells
	MYF-01-37 (1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one) 是共价TEAD 抑制剂，靶向 Cys380，能够可逆地抑制 YAP/TEAD 相互作用。
T131631	17-hydroxyestr-4-en-3-one
	17-hydroxyestr-4-en-3-one 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T131631。
T31738	Eyeseryl Ac-beta-ala-his-ser-his-oh
	Eyeseryl, also known as Acetyl Tetrapeptide-5, humectant or hydroscopic moisturizer which helps reduce eye puffiness, improve skin elasticity as well as overall smoothness.
T10036	10β,17β-dihydroxyestra-1,4-dien-3-one DHED	Others	Others
	10β,17β-dihydroxyestra-1,4-dien-3-one is a brain-targeting bioprecursor prodrug of the main human estrogen, 17β-estradiol. It alleviates hot flushes in rat models of thermoregulatory dysfunction of the brain.
T36039	16α-Hydroxyestrone
	The naturally-occurring estrogens are estrone , estradiol , and estriol . 16α-hydroxy Estrone (16α-OHE1) is a hydroxylated metabolite of E1 as well as an interconversion product with E2. E1 is 16α-hydroxylated by cytochrome P450 (CYP) isoforms, including CYP1A1, CYP3A5, CYP3A4, and CYP3A7, with CYP3A5 being breast-specific. 16α-OHE1 is sulphatized or glucuronidated before excretion. It is increased in rheumatoid arthritis and decreased by physical activity. Unlike the parent estrogens and other ...
T6028	PF 477736 PF 00477736,PF-477736,PF-736,PF-00477736,PF477736	c-Fms; VEGFR; FGFR; FLT; c-RET; Chk; CDK; Src; Aurora Kinase	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors
	PF 477736 (PF-736,PF-00477736) 是一种特异性、有效且具有 ATP 竞争性的 Chk1 抑制剂，Ki 值为0.49 nM。它也是Chk2抑制剂，Ki 值为 47 nM。它还抑制VEGFR2、Fms、Yes、Aurora-A、FGFR3、Flt3和Ret。
T6997	SU6656	FAK; Akt; Src	Angiogenesis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	SU6656 是Src 家族激酶抑制剂，抑制 Src，Yes，Lyn，Fyn 的IC50分别为 280，20，130，170 nM。它还能抑制p-AKT。它可抑制FAK Y576/577、 Y925、Y861位点的磷酸化。
T3063	PD173955 PD-173955,PD 173955	Apoptosis; Bcr-Abl; Src	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	PD173955是一种Src 激酶家族选择性抑制剂，对Src、Yes 和Abl 激酶IC50值约为22nM，对 FGFRα 的效力较低，对InsR 和PKC 无活性。
T6078	Saracatinib AZD0530,塞卡替尼	EGFR; Src; BTK; Autophagy	Angiogenesis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Saracatinib (AZD0530) 是一种有效的 Src 抑制剂，抑制 c-Src、Lck、c-YES、Lyn、Fyn、Fgr 和 Blk 的 IC50值在 2.7 到 11 nM 之间，对其他酪氨酸激酶具有选择性。
T50101	Perilipin-1/5 Inhibitor 1	Others	Others
	1-[4-(2,3-dihydro-1,4-benzodioxine-6-sulfonyl)piperazin-1-yl]-2-(6-methyl-1-benzofuran-3-yl)ethan-1-one 是一种有机结构单元。
T13157	TG 100801 TG100801,TG 100572	VEGFR; Src	Angiogenesis; Tyrosine Kinase/Adaptors
	TG 100801 是 VEGFr2 和 Src 家族（Src 和 YES）激酶的双重抑制剂，是治疗年龄相关性黄斑变性（AMD）的候选化合物。
T69760	TT-10 TAZ-K	YAP	Stem Cells
	TT-10 (TAZ-K) 作为YES相关蛋白(YAP)-转录增强因子结构域(TEAD)活性的激活剂，适用于心肌细胞丢失伴随心脏病研究。
T6093	AZD-7762 AZD7762	Chk	Cell Cycle/Checkpoint
	AZD-7762 是一种有效的 ATP 竞争性的细胞周期检测点激酶抑制剂，抑制 Chk1的 IC50为 5 nM。
T13156	TG 100572	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	TG 100572 is a inhibitor of multi-targeted kinase which inhibits receptor tyrosine kinases and Src kinases(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes, respectively).
T13156L	TG 100572 Hydrochloride	VEGFR; FGFR; PDGFR; Src	Angiogenesis; Tyrosine Kinase/Adaptors
	TG 100572 Hydrochloride 是一种多靶点激酶抑制剂，能够抑制受体酪氨酸激酶和Src 激酶。
T13157L	TG 100801 Hydrochloride	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	TG 100801 Hydrochloride is a prodrug to treat age-related macular degeneration. TG 100572 is a inhibitor of multi-targeted kinase(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src,
T83938	TAT-PDHPS1
	TAT-PDHPS1是一种针对Yes-associated protein (YAP) 信号的肽抑制剂。它由内源性肽PDHPS1和能穿透细胞的肽序列TAT组成。PDHPS1与蛋白磷酸酶2磷酸酶激活因子(PTPA)结合, 激活蛋白磷酸酶2A (PP2A)。该激活促进YAP的磷酸化和抑制YAP靶向基因的表达。TAT-PDHPS1能够抑制体外卵巢癌细胞的增殖和小鼠皮下异种移植肿瘤模型中的卵巢肿瘤生长。

化合物

Cat.No: T9053

Target: Others, YAP

Cat.No: T9954

Target: Others

Cat.No: T3112

Synonym: 维替泊芬,BPD-MA,CL 318952

Target: Apoptosis, YAP, VDA, Autophagy

Cat.No: T8421

Target: YAP

ML-7 hydrochloride

Cat.No: T3050

Synonym: ML-7 HCl,ML-7盐酸盐

Target: Serine/threonin kinase, Myosin, YAP, PKA, PKC

Cat.No: T1477

Synonym: NSC105823,AICA Riboside,Acadesine,阿卡地新,AICAR (Acadesine)

Target: Mitophagy, YAP, AMPK, Autophagy

Cat.No: T22372

Synonym: 1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one

Target: Others, YAP

17-hydroxyestr-4-en-3-one

Cat.No: T131631

Cat.No: T31738

Synonym: Ac-beta-ala-his-ser-his-oh

10β,17β-dihydroxyestra-1,4-dien-3-one

Cat.No: T10036

Synonym: DHED

Target: Others

16α-Hydroxyestrone

Cat.No: T36039

Cat.No: T6028

Synonym: PF 00477736,PF-477736,PF-736,PF-00477736,PF477736

Target: c-Fms, VEGFR, FGFR, FLT, c-RET, Chk, CDK, Src, Aurora Kinase

Cat.No: T6997

Target: FAK, Akt, Src

Cat.No: T3063

Synonym: PD-173955,PD 173955

Target: Apoptosis, Bcr-Abl, Src

Cat.No: T6078

Synonym: AZD0530,塞卡替尼

Target: EGFR, Src, BTK, Autophagy

Perilipin-1/5 Inhibitor 1

Cat.No: T50101

Target: Others

Cat.No: T13157

Synonym: TG100801,TG 100572

Target: VEGFR, Src

Cat.No: T69760

Synonym: TAZ-K

Target: YAP

Cat.No: T6093

Synonym: AZD7762

Target: Chk

Cat.No: T13156

Target: VEGFR

TG 100572 Hydrochloride

Cat.No: T13156L

Target: VEGFR, FGFR, PDGFR, Src

TG 100801 Hydrochloride

Cat.No: T13157L

Target: VEGFR

Cat.No: T83938

Cat. No.	Product Name	Target	Signaling Pathways
T13481	2-Methoxyestrone	Endogenous Metabolite	Metabolism
	2-Methoxyestrone 是甲氧基苯二酚雌激素，也是雌酮代谢物，其 pKa=10.81。
T2220	2-Methoxyestradiol 2-甲氧雌二醇,二甲氧基雌二醇,NSC-659853,2-MeOE2,2-ME2	Apoptosis; Reactive Oxygen Species; Microtubule Associated; Endogenous Metabolite; HIF; Autophagy	Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; NF-κB
	2-Methoxyestradiol (2-ME2) 是一种口服生物可利用的雌二醇代谢物，具有抗肿瘤活性。它通过减少内皮细胞增殖和诱导内皮细胞凋亡来抑制血管生成，也可破坏微管的稳定。它可诱导半胱天冬酶活化，导致细胞周期停滞在 G2 期、DNA 断裂和细胞凋亡。
T9454	4-Hydroxyestrone	Estrogen Receptor/ERR; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	4-Hydroxyestrone 是一种内源性雌激素代谢物，可强烈保护神经元细胞免受氧化损伤。
T9455	4-hydroxyestrone-4-methyl ether 4-Methoxy Estrone,4-甲氧基雌酮	Estrogen Receptor/ERR; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	4-hydroxyestrone-4-methyl ether (4-Methoxy Estrone) 是由COMT 催化的4-OHE1的甲基化反应。

天然产物

2-Methoxyestrone

Cat.No: T13481

Target: Endogenous Metabolite

2-Methoxyestradiol

Cat.No: T2220

Synonym: 2-甲氧雌二醇,二甲氧基雌二醇,NSC-659853,2-MeOE2,2-ME2

Target: Apoptosis, Reactive Oxygen Species, Microtubule Associated, Endogenous Metabolite, HIF, Autophagy

4-Hydroxyestrone

Cat.No: T9454

Target: Estrogen Receptor/ERR, Endogenous Metabolite

4-hydroxyestrone-4-methyl ether

Cat.No: T9455

Synonym: 4-Methoxy Estrone,4-甲氧基雌酮

Target: Estrogen Receptor/ERR, Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04411	YES1 Protein, Human, Recombinant (His & GST) HsT441,c-yes,YES proto-oncogene 1, Src fam...	Human	Baculovirus Insect Cells
	Proto-oncogene tyrosine-protein kinase Yes, also known as Proto-oncogene c-Yes, p61-Yes and YES1, is a cytoplasm protein that belongs to the protein kinase superfamily, Tyr protein kinase family and SRC subfamily. YES1 / c-Yes contains one protein kinase domain, one SH2 domain and one SH3 domain. It is thought that the subcellular distribution of Src-family tyrosine kinases, including c-Yes binding to the cellular membrane, is membranous and/or cytoplasmic. YES1 / c-Yes protein tyrosine kinase i...
TMPJ-01272	WBP1 Protein, Human, Recombinant (His) WBP1,WBP-1,WW Domain-Binding Protein 1	Human	E. coli
	WW Domain-Binding Protein 1 (WBP1) is widely expressed in many tissues, but it is lowly expressed in the lung, placenta, kidney, and liver. WBP1 contains two WW-binding motifs: WW-binding 1 and WW-binding 2 that are involved in mediating protein-protein interactions through the binding of polyproline ligands. The WW-binding domain is composed of 38 to 40 semi-conserved amino acids shared by proteins with diverse functions including structural, regulatory, and signaling proteins. In addition, WBP...

重组蛋白

YES1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04411

Species: Human

Expression System: Baculovirus Insect Cells

WBP1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01272

Species: Human

Expression System: E. coli

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