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111

抑制剂 & 化合物

12

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T38948	MS-PEG4-THP	PROTAC Linker	PROTAC
	MS-PEG4-THP 是PEG 类PROTAC linker，可用于合成 PROTAC 分子。
T40533	THP-PEG10-THP THP-PEG10-THP
	THP-PEG10-THP is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T39237	THP-PEG9-THP THP-PEG9-THP
	THP-PEG9-THP is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T38576	Propargyl-PEG1-THP Propargyl-PEG1-THP
	Propargyl-PEG1-THP is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T40531	THP-PEG10-OH THP-PEG10-OH
	THP-PEG10-OH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T40530	Ms-PEG6-THP Ms-PEG6-THP
	Ms-PEG6-THP is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T39076	Benzyl-PEG8-THP Benzyl-PEG8-THP
	Benzyl-PEG8-THP is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T40780	THP-PEG9-OH THP-PEG9-OH
	THP-PEG9-OH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T40632	MS-PEG12-THP MS-PEG12-THP
	MS-PEG12-THP is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T40779	Benzyl-PEG9-THP Benzyl-PEG9-THP
	Benzyl-PEG9-THP is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T39834	Benzyl-PEG6-THP Benzyl-PEG6-THP
	Benzyl-PEG6-THP is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T40448	MS-PEG3-THP MS-PEG3-THP
	MS-PEG3-THP is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T39835	Benzyl-PEG7-THP Benzyl-PEG7-THP
	Benzyl-PEG7-THP is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T40532	MS-PEG10-THP MS-PEG10-THP
	MS-PEG10-THP is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T38426	Benzyl-PEG4-THP Benzyl-PEG4-THP
	Benzyl-PEG4-THP is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T38705	MS-PEG1-THP MS-PEG1-THP
	MS-PEG1-THP is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T39006	Bromo-PEG2-THP Bromo-PEG2-THP
	Bromo-PEG2-THP is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T39228	Br-PEG4-THP Br-PEG4-THP
	Br-PEG4-THP is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T40444	THP-CH3-ethyl propionate THP-CH3-ethyl propionate
	THP-CH3-ethyl propionate is a PROTAC linker composed of alkyl and ether groups. It finds utility in PROTAC synthesis.
T6628	Pirarubicin 吡柔比星,Theprubicin,THP	Topoisomerase; Antibacterial; Antibiotic; Autophagy	Autophagy; DNA Damage/DNA Repair; Microbiology/Virology
	Pirarubicin (Theprubicin) 是一种蒽环类抗生素，是拓扑异构酶 II 抑制剂，可用于各种癌症的研究。
T9777	THP104c	Mitochondrial Metabolism	Metabolism
	THP104c 是有效的线粒体分裂抑制剂。
T34860	THP-PEG12
	THP-PEG12 is a PEG linker.
T17082	THP-PEG4-OH	Others	Others
	THP-PEG4-OH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18853	Tos-PEG4-THP	Others	Others
	Tos-PEG4-THP is a polyethylene glycol (PEG) derivative utilized as a linker in the synthesis of PROTAC K-Ras Degrader-1, a potential therapeutic compound for targeted degradation of K-Ras protein [1].
T17085	THP-PEG8-OH	Others	Others
	THP-PEG8-OH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17084	THP-PEG6-OH	Others	Others
	THP-PEG6-OH is a polyethylene glycol (PEG)-based PROTAC linker, utilized in the synthesis of PROTACs[1]. It is also a non-cleavable three-unit PEG linker for antibody-drug conjugates (ADCs)[2].
T17087	THP-SS-alcohol	Others	Others
	THP-SS-alcohol is a cleavable linker employed in the synthesis of antibody-drug conjugates (ADCs)[1].
T18845	THP-PEG11-OH	Others	Others
	THP-PEG11-OH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17086	THP-PEG8-Tos	Others	Others
	THP-PEG8-Tos is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17083	THP-PEG5-OH	Others	Others
	THP-PEG5-OH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17081	THP-PEG3-OH	Others	Others
	THP-PEG3-OH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17088	THP-SS-PEG1-Boc	Others	Others
	THP-SS-PEG1-Boc is a cleavable ADC linker comprising a one-unit PEG, commonly employed in the synthesis of antibody-drug conjugates (ADCs)[1].
T17089	THP-SS-PEG1-Tos	Others	Others
	THP-SS-PEG1-Tos is a 1 unit PEG ADC linker that is cleavable. It is employed during the synthesis of antibody-drug conjugates (ADCs)[1].
T18846	THP-PEG4-Pyrrolidine(N-Boc)-CH2OH	Others	Others
	THP-PEG4-Pyrrolidine(N-Boc)-CH2OH is a polyethylene glycol (PEG) based PROteolysis TArgeting Chimera (PROTAC) linker, employed for the synthesis of PROTAC K-Ras Degrader-1, as documented in reference [1].
T18847	THP-PEG4-Pyrrolidine(N-Me)-CH2OH	Others	Others
	THP-PEG4-Pyrrolidine(N-Me)-CH2OH, a PEG-based PROTAC linker, facilitates the synthesis of PROTAC K-Ras Degrader-1[1].
T17058	Tetrahydropyranyldiethyleneglycol THP-PEG2-OH	Others	Others
	Tetrahydropyranyldiethyleneglycol is a polyethylene glycol (PEG)-based PROTAC linker utilized in the synthesis of PROTACs[1].
T67267	THP-PEG1-alcohol
	THP-PEG1-alcohol 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T67267，CAS号为 2162-31-4。
T11492	GSK2983559 free acid	Others; RIP kinase	Apoptosis; NF-κB; Others
	GSK2983559 free acid 是一种有效的特异性受体相互作用蛋白 2 (RIP2) 抑制剂。 GSK2983559 free acid 在阻断人类炎症性肠病外植体样品和体内的许多促炎细胞因子反应方面表现出优异的活性。
T3278	Piribedil EU-4200,Trivastan,ET-495,Trivastal	Dopamine Receptor; Histone Methyltransferase; Adrenergic Receptor	Chromatin/Epigenetic; GPCR/G Protein; Neuroscience
	Piribedil (Trivastan) 是多巴胺 D2受体激动剂，对 hα1A-肾上腺素受体也显示出拮抗作用。
T9552	BAZ1A-IN-1	Epigenetic Reader Domain	Chromatin/Epigenetic
	BAZ1A-IN-1 是BAZ1A（含溴结构域蛋白）抑制剂(Kd:0.52 μM)。它对低表达BAZ1A 的癌细胞表现出弱活性或无活性，但对高表达BAZ1A 的癌细胞系显示出良好的抗生存作用。
T9016	AI-10-47 1H-Benzimidazole, 2-(2-pyridinyl)-6-(trifluoromethoxy)-AI-10-47	Others	Others
	AI-10-47 (1H-Benzimidazole, 2-(2-pyridinyl)-6-(trifluoromethoxy)-AI-10-47) 是 CBFβ-RUNX 结合的小分子抑制剂(IC50:3.2 μM)。
T8531	m-3M3FBS 2,4,6-三甲基-N-[3-(三氟甲基)苯基]苯磺酰胺	Apoptosis; Phospholipase	Apoptosis; Metabolism
	m-3M3FBS 是一种有效的磷脂酶C 激活剂，刺激人中性粒细胞产生超氧物，上调细胞内钙离子浓度，刺激多种细胞产生磷酸肌醇。它诱导单核细胞白血病细胞凋亡。
T28178	NLRP3-IN-9 INF-4E,INF 4E,INF4E	NOD	Immunology/Inflammation; NF-κB
	NLRP3-IN-9 (INF-4E) 是 NLRP3 ATPase 和 caspase-1 的抑制剂。 NLRP3-IN-9 通过不可逆地捕获硫醇亲核体发挥作用，以时间和浓度依赖性方式防止 ATP 和尼日利亚菌素触发的人 THP-1 细胞焦亡。
T60012	HS-243	IRAK; MAPK; CDK	Cell Cycle/Checkpoint; Immunology/Inflammation; MAPK; NF-κB
	HS-243 是 IRAK-4 和 IRAK-1 的抑制剂，IC50 分别为 20 和 24 nM。 HS-243 显示出抗炎和抗癌活性。
T6019	Volasertib BI 6727,伏拉塞替	Apoptosis; PLK	Apoptosis; Cell Cycle/Checkpoint
	Volasertib (BI 6727) 是一种具有口服活性的高效ATP 竞争性Polo 样激酶 1 抑制剂。它抑制 PLK2 和 PLK3，IC50分别为 5 和 56 nM。它是二氢蝶呤酮衍生物，有抗肿瘤活性，可诱导有丝分裂停滞和细胞凋亡。
T10384	Farudodstat ASLAN003	Apoptosis; Dehydrogenase; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Farudodstat (ASLAN003) 是一种具有口服活性的二氢乳清酸脱氢酶 (DHODH) 抑制剂，对人 DHODH 酶的IC50为 35 nM。它通过激活 AP-1 转录因子来抑制蛋白质合成，可以诱导凋亡，并在急性髓样白血病异种移植小鼠中大大延长其生存期。
T7162	R1487 Hydrochloride R1487 (Hydrochloride)	p38 MAPK; Autophagy	Autophagy; MAPK
	R1487 Hydrochloride (R1487(Hydrochloride)) 是一种可口服的高选择性 p38α 抑制剂，对 p38α 和 p38β 的Kd 值分别为 0.2 nM 和 29 nM。
T8506	THPP-1	PDE	Metabolism
	THPP-1 是一种 SGC 推荐的化学探针，是一种口服具有活性的磷酸二酯酶10A 抑制剂，其对人和大鼠的Ki 分别为 1 nM 和 1.3 nM。它的药理学特性良好。
T24880	THPN
	THPN is a Nur77 agonist. It also induces autophagy in melanoma cell lines.
T24648	PK-THPP
	PK-THPP is a channel blocker of TASK-3.

化合物

Cat.No: T38948

Target: PROTAC Linker

THP-PEG10-THP

Cat.No: T40533

Synonym: THP-PEG10-THP

THP-PEG9-THP

Cat.No: T39237

Synonym: THP-PEG9-THP

Propargyl-PEG1-THP

Cat.No: T38576

Synonym: Propargyl-PEG1-THP

Cat.No: T40531

Synonym: THP-PEG10-OH

Cat.No: T40530

Synonym: Ms-PEG6-THP

Benzyl-PEG8-THP

Cat.No: T39076

Synonym: Benzyl-PEG8-THP

Cat.No: T40780

Synonym: THP-PEG9-OH

Cat.No: T40632

Synonym: MS-PEG12-THP

Benzyl-PEG9-THP

Cat.No: T40779

Synonym: Benzyl-PEG9-THP

Benzyl-PEG6-THP

Cat.No: T39834

Synonym: Benzyl-PEG6-THP

Cat.No: T40448

Synonym: MS-PEG3-THP

Benzyl-PEG7-THP

Cat.No: T39835

Synonym: Benzyl-PEG7-THP

Cat.No: T40532

Synonym: MS-PEG10-THP

Benzyl-PEG4-THP

Cat.No: T38426

Synonym: Benzyl-PEG4-THP

Cat.No: T38705

Synonym: MS-PEG1-THP

Bromo-PEG2-THP

Cat.No: T39006

Synonym: Bromo-PEG2-THP

Cat.No: T39228

Synonym: Br-PEG4-THP

THP-CH3-ethyl propionate

Cat.No: T40444

Synonym: THP-CH3-ethyl propionate

Cat.No: T6628

Synonym: 吡柔比星,Theprubicin,THP

Target: Topoisomerase, Antibacterial, Antibiotic, Autophagy

Cat.No: T9777

Target: Mitochondrial Metabolism

Cat.No: T34860

Cat.No: T17082

Target: Others

Cat.No: T18853

Target: Others

Cat.No: T17085

Target: Others

Cat.No: T17084

Target: Others

THP-SS-alcohol

Cat.No: T17087

Target: Others

Cat.No: T18845

Target: Others

Cat.No: T17086

Target: Others

Cat.No: T17083

Target: Others

Cat.No: T17081

Target: Others

THP-SS-PEG1-Boc

Cat.No: T17088

Target: Others

THP-SS-PEG1-Tos

Cat.No: T17089

Target: Others

THP-PEG4-Pyrrolidine(N-Boc)-CH2OH

Cat.No: T18846

Target: Others

THP-PEG4-Pyrrolidine(N-Me)-CH2OH

Cat.No: T18847

Target: Others

Tetrahydropyranyldiethyleneglycol

Cat.No: T17058

Synonym: THP-PEG2-OH

Target: Others

THP-PEG1-alcohol

Cat.No: T67267

GSK2983559 free acid

Cat.No: T11492

Target: Others, RIP kinase

Cat.No: T3278

Synonym: EU-4200,Trivastan,ET-495,Trivastal

Target: Dopamine Receptor, Histone Methyltransferase, Adrenergic Receptor

Cat.No: T9552

Target: Epigenetic Reader Domain

Cat.No: T9016

Synonym: 1H-Benzimidazole, 2-(2-pyridinyl)-6-(trifluoromethoxy)-AI-10-47

Target: Others

Cat.No: T8531

Synonym: 2,4,6-三甲基-N-[3-(三氟甲基)苯基]苯磺酰胺

Target: Apoptosis, Phospholipase

Cat.No: T28178

Synonym: INF-4E,INF 4E,INF4E

Target: NOD

Cat.No: T60012

Target: IRAK, MAPK, CDK

Cat.No: T6019

Synonym: BI 6727,伏拉塞替

Target: Apoptosis, PLK

Cat.No: T10384

Synonym: ASLAN003

Target: Apoptosis, Dehydrogenase, DNA/RNA Synthesis

R1487 Hydrochloride

Cat.No: T7162

Synonym: R1487 (Hydrochloride)

Target: p38 MAPK, Autophagy

Cat.No: T8506

Target: PDE

Cat.No: T24880

Cat.No: T24648

Cat. No.	Product Name	Target	Signaling Pathways
T4038	Ectoine THP(B),L-Ectoine,四氢甲基嘧啶羧酸	Others; Antibacterial	Microbiology/Virology; Others
	Ectoine (L-Ectoine) 是生活在极其恶劣环境中的细菌所产生的氨基酸衍生物，是一种天然的细胞保护剂。它具有良好的安全性，可研究过敏性鼻炎。它用作渗透调节相容性溶质，可增加皮肤表面的水合作用并稳定脂质层，常用于皮肤护理。
T2P2870	Damascenone trans-damascenone,Beta-Damascenone,大马烯酮,大马酮	Others; NF-κB; Endogenous Metabolite	Metabolism; NF-κB; Others
	Damascenone (trans-damascenone) 是一种 E-和 Z-异构体大马士革酮的混合物，源于 Epipremnum pinnatum 的具有抗炎特性的特性化合物。
T9218	Andrograpanin 19-HYDROXY-8(17),13-LABDADIEN-16,15-OLIDE,新穿心莲内酯苷元	p38 MAPK	MAPK
	Andrograpanin (19-HYDROXY-8(17),13-LABDADIEN-16,15-OLIDE) 是来自穿心莲的一种天然产物，具有抗炎和抗感染活性。
T6648	Rotundine Gindarine,L-Tetrahydropalmatine,Caseanine,罗通定,(-)-Tetrahydropalmatine	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Rotundine (Gindarine) 是多巴胺D1、D2和D3受体的拮抗剂，IC50值分别为 166、1.4 和 3.3 μM。它也是5-HT1A 的拮抗剂，IC50值为 370 nM。
TN1879	Lucideric acid A Lucidenic acid A,赤芝酸A	MMP; p38 MAPK; JNK	MAPK; Proteases/Proteasome
	Lucideric acid A (Lucidenic acid A) 是分离自灵芝的天然产物，可抑制 PMA 诱导的MMP-9活性，具有抵抗肝癌细胞侵袭的作用。
T81159	Sibiricine
	Sibiricine（Compound 8），一种从Corydalis crispa药用植物提取的异喹啉类生物碱，对于LPS诱导的THP-1细胞产生的TNF-α显示出显著的抗炎效果。
TN5593	Euphohelioscopin A
	Euphohelioscopin A, an activator of protein kinase C (PKC), it inhibits proliferation and induces differentiation of the myeloid leukemia cell lines THP-1 and HL-60. Euphohelioscopin A has anti-inflammary activity, it exhibits moderate inhibitory activity
T72742	(-)-Pinocembrin (-)-乔松素
	(-)-Pinocembrin 对 H37Ra 结核分枝杆菌展示了抗菌活性，无论是休眠还是活跃期，其 IC50 值分别为1.11 mg/mL 和 1.21 mg/mL。作为一种抗增殖剂，(-)-Pinocembrin 对于 THP-1、A549、Panc-1、HeLa 和 MCF7 细胞系，IC50 值范围为 1.88 至 11.00 mg/mL。
T37751	Streptazolin
	Streptazolin is a fungal metabolite originally isolated from S. viridochromogenes. It increases NF-κB activity when used at concentrations ranging from 60 to 130 μg/ml, at least in part, via PI3K signaling. Streptazolin enhances TNF-α secretion induced by LPS and enhances IL-8 secretion when used alone or in combination with LPS in THP-1 Blue cells.
TN5238	Viscidulin II	IL Receptor; TNF	Apoptosis; Immunology/Inflammation
	Viscidulin II can be potential therapeutic agents against P. acnes-induced skin inflammation, it can significantly suppress P. acnes-induced IL-8 and IL-1β production in THP-1 cells, concomitant intradermal injection of viscidulin II with P. acnes can effectively attenuate P. acnes-induced ear swelling, and decrease the production of IL-6 and tumor necrosis factor-α in ear homogenates.
T37442	Aspergillin PZ
	Aspergillin PZ is a fungal metabolite originally isolated from A. awamori. It induces morphological deformation of P. oryzae conidia when used at a concentration of 89 nM. Aspergillin PZ is active against S. epidermidis (MIC = 20 μM) but not S. aureus, E. coli, or B. cereus (MICs = >20 μM). It is cytotoxic to HL-60 promyelocytic leukemia cells (IC50 = 56.61 μM) but not THP-1 acute monocytic leukemia or PC3 prostate cancer cells (IC50s = >80 μM).
TN3395	Alpinone 3-acetate	IFNAR	Immunology/Inflammation
	Alpinone 3-acetate 具有抗炎作用，可抑制12-O-tetradecanophenol 13-acetate 所致小鼠耳部水肿模型的炎症反应。Alpinone 3-acetate 是Alpinone 衍生物。Alpinone 是一种具有活性的天然化合物，来源于向日葵，具有免疫调节和抗病毒活性。

天然产物

Cat.No: T4038

Synonym: THP(B),L-Ectoine,四氢甲基嘧啶羧酸

Target: Others, Antibacterial

Cat.No: T2P2870

Synonym: trans-damascenone,Beta-Damascenone,大马烯酮,大马酮

Target: Others, NF-κB, Endogenous Metabolite

Cat.No: T9218

Synonym: 19-HYDROXY-8(17),13-LABDADIEN-16,15-OLIDE,新穿心莲内酯苷元

Target: p38 MAPK

Cat.No: T6648

Synonym: Gindarine,L-Tetrahydropalmatine,Caseanine,罗通定,(-)-Tetrahydropalmatine

Target: Dopamine Receptor, 5-HT Receptor

Lucideric acid A

Cat.No: TN1879

Synonym: Lucidenic acid A,赤芝酸A

Target: MMP, p38 MAPK, JNK

Cat.No: T81159

Euphohelioscopin A

Cat.No: TN5593

(-)-Pinocembrin

Cat.No: T72742

Synonym: (-)-乔松素

Cat.No: T37751

Cat.No: TN5238

Target: IL Receptor, TNF

Cat.No: T37442

Alpinone 3-acetate

Cat.No: TN3395

Target: IFNAR

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