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32
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T19066 |
Thioflavine S
硫磺素,Thioflavin S,Direct Yellow 7 |
Others | Others |
Thioflavine S (Direct Yellow 7) 是荧光组织化学标记物,可用于老年斑块致密核心的标记。 | |||
T68171L |
Zabicipril HCl
Zabicipril HCl(83059-56-7 Free base),S 9650,S 10211 |
Angiotensin-converting Enzyme (ACE) | Metabolism |
Zabicipril HCl(S 9650) 是一种有效的血管紧张素转换酶抑制剂。 | |||
T63166L |
(S, R)-LSN 3318839
(S, R)-LSN 3318839(Isomer-2764704-18-7) |
Glucagon Receptor | GPCR/G Protein |
T15190L |
(S,R,S)-AHPC-PEG4-NH2
VHL Ligand-Linker Conjugates 4,E3 ligase Ligand-Linker Conjugates 7 Free Base,VH032-PEG4-NH2 |
Others; Ligand for E3 Ligase | Others; PROTAC |
(S,R,S)-AHPC-PEG4-NH2 (VHL Ligand-Linker Conjugates 4) 是一种合成的 E3 连接酶配体-接头偶联物,包含基于 (S,R,S)-AHPC 的 VHL 配体和 4 单元 PEG 接头。 | |||
T16834 |
S26131
N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide |
MT Receptor | Neuroscience |
S26131 (N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide) 是一种选择性的褪黑激素配体 MT1 和 MT2 拮抗剂,对 MT1 和 MT2 的 Ki 值分别为 0.5 和 112 nM。 | |||
T36999 |
7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
|
||
Novel oxylipins, referred to as docosanoids, have been derived from C22polyunsaturated fatty acids 7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic acid (7(S),17(S)-hydroxy DPA) is a DPA-derived analog of the 17(S)-dihydroxy series of docosanoids known as protectins. Protectin D1, a DHA-derived dihydroxy fatty acid, exhibits potent anti-inflammatory activities.1,2,3Potentially, 7(S),17(S)-hydroxy DPA demonstrates similar properties; however, its biological activity has yet to b... | |||
T13876 |
(S,R,S)-AHPC-propargyl
VHL ligand 7,VH032-propargyl |
Others | Others |
(S,R,S)-AHPC-propargyl is a VHL ligand which is used in "click reaction" for PROTACs. | |||
T19848 |
Cyclosporin B
7-L-Alanine-cyclosporin A,Antibiotic S 7481F2 |
||
Cyclosporin B is an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. Cyclosporin B displays antiviral properties, inhibiting the entry of hepatitis B into hepatocytes. Cyclosporin B also | |||
T37606 |
Resolvin D5
7(S),17(S)-diHDHA |
||
Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid . [1] In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.[2] Resolvin D5 (RvD5) is a DHA-derived resolvin generated by a double dioxygenation mechanism.[3] RvD5 has been identified in media from ionophore-stimulated trout brain cells, in human synovial fluid from patients with rheumatoid arthritis, and in... | |||
T18671 |
(S,R,S)-AHPC-Me-C7 ester
|
Others | Others |
(S,R,S)-AHPC-Me-C7 ester is a E3 ligase ligand-linker conjugate used to synthesise BCL-XL PROTAC degraders[1]. | |||
T22526 |
BML-111
5(S),6(R)-7-trihydroxymethyl Heptanoate |
Others | Others |
inhibits leukotriene B4 (LTB4)-induced polymorphonuclear neutrophils (PMN) chemotaxis | |||
T39838 |
(S,R,S)-AHPC-C7-amine
VH032-C7-amine,(S,R,S)-AHPC-C7-amine |
||
(S,R,S)-AHPC-C7-amine, also known as VH032-C7-amine, is a chemically synthesized conjugate that functions as an E3 ligase ligand-linker. This compound combines the VH032-based VHL ligand with a specific linker designed for the degradation of estrogen-related receptor α (ERRα) PROTAC. | |||
T17910 |
(S,R,S)-AHPC-PEG2-C4-Cl
E3 ligase Ligand-Linker Conjugates 10,VHL Ligand-Linker Conjugates 7,VH032-PEG2-C4-Cl |
Others | Others |
(S,R,S)-AHPC-PEG2-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-PEG2-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1]. | |||
T15190 |
(S,R,S)-AHPC-PEG4-NH2 hydrochloride
E3 ligase Ligand-Linker Conjugates 7,VH032-PEG4-NH2 hydrochloride,VHL Ligand-Linker Conjugates 4 hydrochloride |
Others | Others |
(S, R, S)-AHPC-PEG4-NH2 hydrochloride is a chemically synthesized conjugate consisting of an E3 ligase ligand-linker, incorporating the VHL ligand based on (S, R, S)-AHPC, and a 4-unit PEG linker, which are specifically designed for use in PROTAC technology. | |||
T24606 |
PDE7 inhibitor S14
PDE7 inhibitor-S14,S14 |
||
PDE7 inhibitor S14 is a cell-permeable PDE7 inhibitor that acts by targeting the cyclic adenosine monophosphate (cAMP)/cAMP-response element-binding protein (CREB) pathway. | |||
T60186 |
(S)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-2-(pyrimidin-5-yl)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide
|
Discoidin Domain Receptor (DDR) | Tyrosine Kinase/Adaptors |
MitoBloCK-6 是一种有效的 Erv1/ALR 抑制剂,IC50 分别为 900 nM 和 700 nM。MitoBloCK-6 还抑制 Erv2 (IC50=1.4 μM)。MitoBloCK-6 可通过细胞色素 c 的释放诱导 hESCs 细胞凋亡。 | |||
T66391 |
(S)-N4-(3-Chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
|
||
(S)-N4-(3-Chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66391,CAS号为 314771-76-1。 | |||
T67218 |
(S)-N,N-Dimethyl-1,2,4,5,6,7-hexahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-12-amine
|
||
(S)-N,N-Dimethyl-1,2,4,5,6,7-hexahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-12-amine 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T67218,CAS号为 443965-10-4。 | |||
T66550 |
(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine
|
||
(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66550,CAS号为 314771-88-5。 | |||
T65424 | (S)-(-)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido-[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid | ||
(S)-(-)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido-[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T65424,CAS号为 100986-89-8。 | |||
T65672 | (S)-Ethyl 9,10-difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate | ||
(S)-Ethyl 9,10-difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T65672,CAS号为 106939-34-8。 | |||
T64794 | (11aR)-N,N-Bis((S)-1-phenylethyl)-4,5,6,7-tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-12-amine | ||
(11aR)-N,N-Bis((S)-1-phenylethyl)-4,5,6,7-tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-12-amine 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T64794。 | |||
T67324 | (1'R,3a'R,8a'S,9'S,9a'S)-1'-Methyl-3'-oxo-N,N-diphenyl-3',3a',5',7',8',8a',9',9a'-octahydro-1'H-spiro[[1,3]dioxolane-2,6'-naphtho[2,3-c]furan]-9'-carboxamide | ||
(1'R,3a'R,8a'S,9'S,9a'S)-1'-Methyl-3'-oxo-N,N-diphenyl-3',3a',5',7',8',8a',9',9a'-octahydro-1'H-spiro[[1,3]dioxolane-2,6'-naphtho[2,3-c]furan]-9'-carboxamide 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T67324,CAS号为 900160-98-7。 | |||
T60358 |
sEH inhibitor-7
|
Epoxide Hydrolase | Metabolism |
sEH inhibitor-7是一种可溶性环氧化物水解酶(sEH)抑制剂,对人和小鼠的 sEH 有抑制作用,IC 50 s 分别为 6.2 μM 和0.15 μM 。sEH inhibitor-7与抗炎活性分子有关。 | |||
T64377 |
AGI-41998 tautomers
|
Others | Others |
AGI-41998 tautomers 是pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-bromophenyl)-6-(4-methoxyphenyl)-2-[(2,2,2-trifluoroethyl)amino]-. pyrido[4,3-d]pyrimidin-7(6H)-one 的互变异构体。pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-bromophenyl)-6-(4-methoxyphenyl)-2-[(2,2,2-trifluoroethyl)amino]-. pyrido[4,3-d]pyrimidin-7(6H)-one 是S-adenosylmethionine synthase isoform type-2抑制剂, IC50= 0.022μM。 | |||
Fr13587 |
7-Chloro-4-(piperazin-1-yl)quinoline
|
||
7-Chloro-4-(piperazin-1-yl)quinolone 结构是药物化学中的重要支架,它单独或与其他活性药效团混合显示出多种药理特性。7-Chloro-4-(piperazin-1-yl)quinolone 是有效的sirtuin 抑制剂,并且抑制 5-羟色胺的摄取,IC50值为 50 μM。7-Chloro-4-(piperazin-1-yl)quinolone 对恶性疟原虫 D10 和 K1 菌株表现出抗疟疾活性,IC50分别为 1.18 μM 和 0.97 μM。 | |||
T35610 |
2,5-dimethyl Celecoxib
|
Apoptosis; Wnt/beta-catenin; Prostaglandin Receptor | Apoptosis; Cytoskeletal Signaling; GPCR/G Protein; Immunology/Inflammation; Stem Cells |
2,5-dimethyl Celecoxib 是塞来昔布衍生物和微粒体前列腺素 E 合酶 1 (mPGES-1) 的靶向抑制剂,mPGES-1 是炎症介质 PGE2 合成途径中的关键酶。 | |||
T36141 |
Boscalid
|
Mitochondrial Metabolism | Metabolism |
Boscalid 是一种广谱羧酰胺类杀菌剂,通过与线粒体复合物 II/琥珀酸脱氢酶的泛醌位点结合来抑制真菌呼吸。 | |||
T37001 |
7-epi Maresin 1
|
||
7-epi Maresin 1 is the inactive 7(S) epimer of Maresin 1 , which contains a 7(R) hydroxyl group. It can be used as an experimental negative control. | |||
T66357 |
(S)-2-((S)-2-Cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoic acid
|
||
(S)-2-((S)-2-Cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoic acid 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66357,CAS号为 402958-96-7。 | |||
T65786 |
(S)-3-Amino-4-hydroxybutanoic acid
|
||
(S)-3-Amino-4-hydroxybutanoic acid 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T65786,CAS号为 16504-57-7。 | |||
T65972 |
(S)-1-(tert-Butoxycarbonyl)-2-methylpyrrolidine-2-carboxylic acid
|
||
(S)-1-(tert-Butoxycarbonyl)-2-methylpyrrolidine-2-carboxylic acid 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T65972,CAS号为 103336-06-7。 | |||
T83874 |
S-72
|
||
S-72是一种微管聚合抑制剂,以1, 3, 10 µM的浓度在无细胞测定中抑制微管聚合,并在MCF-7和耐紫杉醇的MCF-7/T乳腺癌细胞中降低细胞活性(IC50分别为15.64和26.32 nM)。50 nM浓度的S-72能抑制MCF-7和MCF-7/T细胞的迁移和侵袭,并减少划痕实验中的伤口闭合百分比。100 nM的S-72在MCF-7/T细胞中诱导G2/M期的细胞周期阻滞以及凋亡,并在同一浓度下抑制这些细胞中干扰素基因激活剂(STING)的激活。以每天15 mg/kg的剂量,S-72抑制了耐紫杉醇的MCF-7/T和MX-1/T小鼠异种移植模型中的肿瘤生长。 | |||
T123887 |
N-?-Glutamyl-S-(allylthio)cysteine
|
||
N-?-Glutamyl-S-(allylthio)cysteine 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T123887,CAS号为 94504-37-7。 | |||
T66493 |
(S)-2-((Carboxymethyl)amino)propanoic acid
|
||
(S)-2-((Carboxymethyl)amino)propanoic acid 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66493,CAS号为 56857-47-7。 | |||
T66081 |
(S)-1-tert-Butyl 5-methyl 2-aminopentanedioate hydrochloride
|
||
(S)-1-tert-Butyl 5-methyl 2-aminopentanedioate hydrochloride 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66081,CAS号为 34582-33-7。 | |||
T60410 |
ART-IN-1
|
||
ART-IN-1 (compound 7) 是一种 PARP 的选择性抑制剂,对 PARP2, TNKS2, PARP10, PARP14, PARP15 的 IC50值分别为 19, 22, 2.4, >100, 1.1 μM。 | |||
T65614 |
(S)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-(tert-butoxy)-5-oxopentanoic acid
|
||
(S)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-(tert-butoxy)-5-oxopentanoic acid 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T65614,CAS号为 84793-07-7。 | |||
T38324 |
Coumarin Boronic Acid
|
||
Coumarin boronic acid (CBA) is a fluorescent probe that can be used to detect peroxynitrite , hypochlorous acid, and hydrogen peroxide.It reacts with peroxynitrite at an exponentially faster rate (k = 1.1 μM/s) than hydrogen peroxide (k =1.5 M/s) and moderately faster rate than hypochlorous acid. Peroxynitrite oxidizes CBA into the fluorescent product 7-hydroxycoumarin (COH), which displays excitation/emission maxima of 332/470 nm, respectively. | |||
T65813 |
(S)-3-Amino-4-methoxy-4-oxobutanoic acid
|
||
(S)-3-Amino-4-methoxy-4-oxobutanoic acid 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T65813,CAS号为 17812-32-7。 | |||
T65024 |
(S)-2-(2-((tert-Butoxycarbonyl)amino)propanamido)acetic acid
|
||
(S)-2-(2-((tert-Butoxycarbonyl)amino)propanamido)acetic acid 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T65024,CAS号为 28782-78-7。 | |||
T67027 |
(S)-2-((tert-Butoxycarbonyl)amino)pent-4-enoic acid
|
||
(S)-2-((tert-Butoxycarbonyl)amino)pent-4-enoic acid 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T67027,CAS号为 90600-20-7。 | |||
T66527 |
(S)-2-Amino-2-cyclopropylacetic acid
|
||
(S)-2-Amino-2-cyclopropylacetic acid 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66527,CAS号为 49606-99-7。 | |||
T65844 |
(S)-2-((tert-Butoxycarbonyl)amino)-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanoic acid
|
||
(S)-2-((tert-Butoxycarbonyl)amino)-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanoic acid 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T65844,CAS号为 200124-22-7。 | |||
T36606 |
(±)7-HDHA
|
||
(±)7-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. Enzymatic transformation of DHA by RBL-1 cells and human neutrophils also produces 7-HDHA. However, the enzymatic product is most likely the S-isomer. (±)7-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid. | |||
T64609 | 2-Ethylbutyl ((S)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate | ||
2-Ethylbutyl ((S)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T64609,CAS号为 1911578-98-7。 | |||
T66717 |
(S)-Methyl 2-((tert-butoxycarbonyl)amino)-3-iodopropanoate
|
||
(S)-Methyl 2-((tert-butoxycarbonyl)amino)-3-iodopropanoate 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66717,CAS号为 170848-34-7。 | |||
T66476 |
(S)-2-((tert-Butoxycarbonyl)amino)-3-(4-carbamoyl-2,6-dimethylphenyl)propanoic acid
|
||
(S)-2-((tert-Butoxycarbonyl)amino)-3-(4-carbamoyl-2,6-dimethylphenyl)propanoic acid 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66476,CAS号为 623950-02-7。 | |||
T78051 |
Necrocide 1
|
Others | Others |
Necrocide 1(化合物(S)-38)是一款有效的抗癌药物,具备显著的抗增殖效果,针对MCF-7和PC3细胞株的IC50值分别为0.48 nM及2 nM。 | |||
T67239 |
Tetrakis[(S)-(+)-(1-adamantyl)-(N-phthalimido)acetato]dirhodium(II)
|
||
Tetrakis[(S)-(+)-(1-adamantyl)-(N-phthalimido)acetato]dirhodium(II) 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T67239,CAS号为 909389-99-7。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6491 |
(-)-(S)-Equol
(−)-Equol,Equol,4',7-Dihydroxyisoflavan,4',7-Isoflavandiol,雌马酚 |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
(-)-(S)-Equol (4',7-Dihydroxyisoflavan) 是雌激素受体β的高亲和力配体。 | |||
T12796 |
S-Dihydrodaidzein
S-二氢大豆苷元,(3S)-7-hydroxy-3-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one |
Others | Others |
S-Dihydrodaidzein ((3S)-7-hydroxy-3-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one) 是一种 dihydrodaidzein 的 (S) 型对映体。其中 dihydrodaidzein 是一种可食用性植物雌激素。 | |||
T2S1682 |
Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside
Pinocembrin 7-O-(3''-galloyl-4'',6''-(S)-hexahydroxydiphenoyl)-beta-D-glucose,pinocembrin-7-o-3-o-galloyl-4-6-hexahydroxydiphenoyl-beta-d-glucoside |
Amylase | Metabolism |
Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside 可抑制 α-淀粉酶活性,IC50值为0.03 umol/ml。 | |||
T83521 |
(S)-7-O-Methylpeucedanol 3′-O-β-D-glucopyranoside
|
||
(S)-7-O-Methylpeucedanol 3'-O-β-D-glucopyranoside 为一种香豆素糖苷[sup][1]。 | |||
TN6837 |
Syringopicroside
2-(4-hydroxyphenyl)ethyl (1S,4aS,7R)-7-methyl-6-oxo-1-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1H,4aH,5H,6H,7H,7aH-cyclopenta[c]pyran-4-carboxylate |
Others | Others |
Syringopicroside (2-(4-hydroxyphenyl)ethyl (1S,4aS,7R)-7-methyl-6-oxo-1-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1H,4aH,5H,6H,7H,7aH-cyclopenta[c]pyran-4-carboxylate) 是一种来自 Syringa oblata Lindl (S. oblata) 的具有抗菌活性的天然药物。 | |||
T5S0994 |
N-Methylcytisine
N-甲基野靛碱,Caulophylline |
Others; AChR | Neuroscience; Others |
N-Methylcytisine (Caulophylline) 是苦参中的一种三环喹啉类生物碱,具有降血糖、缓解疼痛和抗炎活性。它是中枢神经系统中乙酰胆碱烟碱受体的选择性配体,对鱿鱼视神经节中的烟碱乙酰胆碱受体具有很高的亲和力,Kd 为 50 nM。 | |||
T0486L |
Irinotecan Hydrochloride
盐酸伊立替康,伊立替康盐酸盐,Camptothecin 11 hydrochloride,CPT-11 hydrochloride |
Topoisomerase; Autophagy | Autophagy; DNA Damage/DNA Repair |
Irinotecan Hydrochloride (CPT-11 hydrochloride) 是喜树碱半合成衍生物的盐酸盐,是一种拓扑异构酶 I 抑制剂,可研究结肠癌和直肠癌。 | |||
T6S0221 |
Eriocitrin
eriodictyol 7-rutinoside,圣草次甙,Eriodictyol-7-O-Rutinoside,Eriodictioside,圣草次甙;圣草次苷,Eriodictyol glycoside |
Apoptosis; Carbonic Anhydrase | Apoptosis; Metabolism |
Eriocitrin (Eriodictyol-7-O-Rutinoside) 是从柠檬中分离出来的一种黄酮类天然产物,是强效的抗氧化剂。它通过激活线粒体涉及的内在信号传导途径来触发细胞凋亡。它通过上调 p53、cyclin A、cyclin D3 和 CDK6 使 S 期细胞周期停滞,从而抑制肝癌细胞的增殖。 | |||
TN6669 |
S-(5'-Adenosyl)-L-methionine chloride
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S-(5'-Adenosyl)-L-methionine chloride是一种天然产物,其产品编号为 TN6669,CAS号为 24346-00-7。S-(5'-Adenosyl)-L-methionine chloride可用作对照参考。 | |||
TN4264 |
Isoapetalic acid
胡桐,海棠木 |
HIV Protease; Antifection | Microbiology/Virology; Proteases/Proteasome |
Isoapetalic acid and apetalic acid exhibit cytotoxic activities towards both cancer cell lines(human breast cancer (MCF-7) and human lung carcinoma (A-549) cell lines) and both Gram-positive bacteria(two Gram-positive bacteria, S. aureus and B. subtilis a | |||
TN5930 |
Ocotillone
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Ocotillone has potent antibacterial activity against Gram-negative bacteria, P. aeruginosa and S. typhimurium, that are without hemolytic activity, whereas it has weak antimicrobial activity against Gram-positive bacteria and fungi. Ocotillone shows only | |||
T35754 |
Aszonapyrone A
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Aszonapyrone A is a meroditerpene fungal metabolite that has been found in Neosartorya and has diverse biological activities.1,2,3 It inhibits the growth of MCF-7, NCI H460, and A375-C5 cancer cells (GI50s = 13.6, 11.6, and 10.2 μM, respectively).1 Aszonapyrone A is active against multidrug-resistant isolates of S. aureus, E. faecalis, and E. faecium (MICs = 8, 16, and 16 μg/ml, respectively) and inhibits S. aureus biofilm formation.2 It is also active against P. falciparum in vitro (IC50 = 1.34... | |||
T35752 |
Xanthoquinodin A1
Xanthoquinodin A1 |
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Xanthoquinodin A1 is a fungal metabolite that has been found inHumicolaand has diverse biological activities.1,2It inhibitsE. tenellaschizont formation in BHK-21 cells with a minimum effective concentration (MEC) value of 0.02 μg/ml.1Xanthoquinodin A1 is active againstB. subtilis,M. luteus,S. aureus,A. laidlawii, andB. fragilisin a disc assay when used at a concentration of 1 mg/ml. It is also active againstB. cereus(MIC = 0.44 μM).2Xanthoquinodin A1 is cytotoxic to KB, MCF-7, and NCI H187 cance... | |||
T35758 | Butyrolactone V | ||
Butyrolactone V is a fungal metabolite that has been found in A. terreus and has antiprotozoal, antioxidant, and anticancer activities.1,2,3 It is active against the P. falciparum strain K1 (IC50 = 7.9 μg/ml) and L. amazonensis promastigotes (IC50 = 23.7 μM).2,1 Butyrolactone V (227 and 454.1 μM) is also active against adult S. mansoni worms.1 It scavenges 2,2-diphenyl-1-picrylhydrazyl and ABTS radicals with IC50 values of 20.7 and 3.7 μM, respectively, in cell-free assays.3 Butyrolactone V also... | |||
T37452 |
Stephacidin B
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Stephacidin B is a fungal metabolite that has been found inA. ochraceus.1Dimeric stephacidin B is rapidly converted to a monomer, avrainvillamide ,in vitro.2Stephacidin B is cytotoxic to a variety of cancer cells, including testosterone-independent PC3 and -sensitive LNCaP prostate cancer cells (IC50s = 0.37 and 0.06 μM, respectively) and estradiol-independent SK-BR-3 and -sensitive MCF-7 breast cancer cells (IC50s = 0.32 and 0.27 μM, respectively).1It induces apoptosis in HepG2 and Huh7 hepatoc... | |||
T36448 |
(E)-Ajoene
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(E)-Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities.1,2,3,4It is active against Gram-positive and Gram-negative bacteria (MICs = 10-250 and 150->500 μg/ml, respectively) and fungi (MICs = 15-50 μg/ml).1(E)-Ajoene inhibits proliferation of a variety of cancer cells, including MDA-MB-231 breast, HeLa cervical, and WHCO1 esophageal cancer cells (IC50s = 18.6, 61, and 39.2 μM, respectively).2It also inhibits human glutathione reductase andT. cruzitrypanoth... |
Cat. No. | Product Name | Species | Expression System |
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TMPY-04951 |
CD27/TNFRSF7 Protein, Human, Recombinant (His), Biotinylated
S152.LPFS2,T14,S152. LPFS |
Human | Baculovirus Insect Cells |
CD27/TNFRSF7 Protein, Human, Recombinant (His), Biotinylated is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 20.77 kDa and the accession number is P26842. | |||
TMPY-03401 |
CD27/TNFRSF7 Protein, Human, Recombinant (His)
S152. LPFS2,CD27 molecule,S |
Human | Baculovirus Insect Cells |
CD27/TNFRSF7 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 20.77 kDa and the accession number is P26842. | |||
TMPY-05271 |
CD20 Protein, Human, Recombinant (TrxA), Biotinylated
MS4A2,CD20,LEU-16,CVID5,membrane-spanning ... |
Human | E. coli |
CD20 Protein, Human, Recombinant (TrxA), Biotinylated is expressed in E. coli expression system with TrxA tag. The predicted molecular weight is 23.9 kDa and the accession number is A0A024R507. | |||
TMPY-02043 |
PARK7/DJ-1 Protein, Human, Recombinant (His)
DJ1,HEL-S-67p,DJ-1,parkinson prot... |
Human | E. coli |
Parkinson's disease locus DJ-1 (PARK7) is a differentially expressed transcript. DJ-1 plays a physiologic role in protection of erythroid cells from oxidant damage, a function unmasked in the context of oxidative stress. PARK7 belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress... | |||
TMPY-05759 |
Annexin V/ANXA5 Protein, Human, Recombinant, Biotinylated
RPRGL3,ANX5,HEL-S-7,annexin A5,PP4,ENX2 |
Human | E. coli |
Annexin V/ANXA5 Protein, Human, Recombinant, Biotinylated is expressed in E. coli expression system. The predicted molecular weight is 35.9 kDa and the accession number is P08758. | |||
TMPY-02540 |
Annexin V/ANXA5 Protein, Human, Recombinant
RPRGL3,HEL-S-7,PP4,annexin A5,ENX2,ANX5 |
Human | E. coli |
Annexin V/ANXA5 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 35.9 kDa and the accession number is P08758. | |||
TMPK-00152 |
CD27/TNFRSF7 Protein, Cynomolgus, Recombinant (His)
CD27 antigen,S152. LPFS2,S |
Cynomolgus | HEK293 Cells |
CD27, also known as TNFRSF7, is an approximately 55 kDa transmembrane protein in the TNF receptor superfamily. It functions as a co‑stimulatory molecule that supports lymphocyte activation and survival. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. | |||
TMPH-01185 |
CYP2C19 Protein, Human, Recombinant (His & Myc)
Cytochrome P450 2C19,(R)-limonene 6-monooxygenase,(... |
Human | E. coli |
CYP2C19 Protein, Human, Recombinant (His & Myc) is expressed in E. coli. | |||
TMPK-00749 |
PGLYRP1 Protein, Mouse, Recombinant (hFc)
PGRPSMGC126896,TNFSF3L,PGLYRP1,TAG7 |
Mouse | HEK293 Cells |
Innate immunity protein Tag7 (PGRP-S, PGLYRP1) can interact with the TNFα receptor, TNFR1, and block the transduction of apoptotic signals through this receptor. A complex formed between the Tag7 protein and the major heat shock protein Hsp70 can activate TNFR1 receptor and induce tumor cell death via either apoptotic or necroptotic pathway. PGLYRP1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 45.7 kDa and the accessio... | |||
TMPK-00745 |
PGLYRP1 Protein, Human, Recombinant (hFc)
PGLYRP1,TAG7,PGLYRP,PGRP-SMGC126894,PGRP,T... |
Human | HEK293 Cells |
Innate immunity protein Tag7 (PGRP-S, PGLYRP1) can interact with the TNFα receptor, TNFR1, and block the transduction of apoptotic signals through this receptor. A complex formed between the Tag7 protein and the major heat shock protein Hsp70 can activate TNFR1 receptor and induce tumor cell death via either apoptotic or necroptotic pathway. PGLYRP1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 46.2 kDa and the accessio... | |||
TMPY-05415 |
CD27/TNFRSF7 Protein, Human, Recombinant (hFc & Avi), Biotinylated
S152,CD27 molecule,TNFRSF7 |
Human | HEK293 Cells |
CD27/TNFRSF7 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 47.8 kDa and the accession number is P26842. | |||
TMPY-03070 |
CD27/TNFRSF7 Protein, Human, Recombinant (rFc)
T14,S152. LPFS2,S152,Tp55,TNFR |
Human | HEK293 Cells |
CD27/TNFRSF7 Protein, Human, Recombinant (rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 44.4 kDa and the accession number is P26842. | |||
TMPY-05445 |
CD27/TNFRSF7 Protein, Human, Recombinant (hFc)
CD27 molecule,T14,S152.LPFS2,Tp55... |
Human | HEK293 Cells |
CD27/TNFRSF7 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.1 kDa and the accession number is P26842. | |||
TMPH-01186 |
CYP2C9 Protein, Human, Recombinant (His & Myc)
CYP2C10,Cytochrome P450 2C9,S-mephenytoin 4-hydroxy... |
Human | E. coli |
CYP2C9 Protein, Human, Recombinant (His & Myc) is expressed in E. coli. | |||
TMPY-04615 |
CD20 Protein, Human, Recombinant (TrxA)
MS4A2,CD20,CVID5,S7,Bp35,membrane... |
Human | E. coli |
CD20 Protein, Human, Recombinant (TrxA) is expressed in E. coli expression system with TrxA tag. The predicted molecular weight is 23.9 kDa and the accession number is A0A024R507. | |||
TMPY-02819 |
CD20 Protein, Human, Recombinant (aa 213-297, His)
Bp35,MS4A2,LEU-16,CVID5,MS4A1,membrane- |
Human | HEK293 Cells |
CD20 Protein, Human, Recombinant (aa 213-297, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 12.1 kDa and the accession number is A0A024R507. | |||
TMPK-00183 |
CD20 Protein, Human, Recombinant (His & Avi)
MS4A2,Ly-44,LEU-16,MS4A1,Bp35,CD20 recepto... |
Human | E. coli |
B-lymphocyte antigen CD20 or CD20 is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R , CD117) and progressively increasing in concentration until maturity.CD20 is the target of the monoclonal antibodies rituximab, ocrelizumab, obinutuzumab, ofatumumab, ibritumomab tiuxetan, tositumomab, and ublituximab, which are all active agents in the treatment of all B cell lymphomas, leukemias, and B cell-mediated autoimmune diseases. CD20... | |||
TMPY-06036 |
FGFR1 Protein, Human, Recombinant (alpha (IIIb), His)
FGFR-1,FLG,CD331,HH2,FLT2,KAL2,FGFBR,HBGFR,CEK,HRTFDS |
Human | HEK293 Cells |
FGFR1 Protein, Human, Recombinant (alpha (IIIb), His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40.5 kDa and the accession number is P11362-7. | |||
TMPH-03434 |
BIO3 Protein, S. cerevisiae, Recombinant (His & Myc)
Diaminopelargonic acid synthase,BIO3,7... |
Saccharomyces cerevisiae | E. coli |
Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor. BIO3 Protein, S. cerevisiae, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 58.7 kDa and the accession number is P50277. | |||
TMPH-03603 |
KcsA Protein, S. coelicolor, Recombinant (His)
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Streptomyces coelicolor | E. coli |
Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel. KcsA Protein, S. coelicolor, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 23.7 kDa and the accession number is P0A333. | |||
TMPH-00573 |
DAPA aminotransferase Protein, E. coli, Recombinant (His & Myc)
DAPA AT,bioA,7,8-diaminononanoate syntha |
E. coli | E. coli |
Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor. Complements a bioU deletion in Synechocystis PCC 6803. | |||
TMPH-01240 |
MCM2 Protein, Human, Recombinant (His)
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Human | E. coli |
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active ... | |||
TMPY-03338 |
GSTZ1 Protein, Human, Recombinant (His)
MAI,GSTZ1-1,glutathione S-transfe... |
Human | E. coli |
GSTZ1 (Glutathione S-Transferase Zeta 1) is a Protein Coding gene. 3 alternatively spliced human isoforms have been reported. GSTZ1 gene is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. GSTZ1 is a bifunctional protein that has minimal glutathione-conjugating activity with ethacrynic acid ... | |||
TMPH-00188 |
BioAB Protein, Bacteroides fragilis, Recombinant (His & Myc)
Adenosylmethionine-8-amino-7-oxononanoate ... |
Bacteroides fragilis | E. coli |
Catalyzes two activities which are involved in the biotine biosynthesis: the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism, and the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). BioAB Protein, Bacteroides fragilis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The p... | |||
TMPY-02921 |
CDK2AP2 Protein, Human, Recombinant (His)
DOC-1R,p14,cyclin-dependent kinase 2 as |
Human | E. coli |
CDK2AP2 belongs to the CDK2AP family. Members of this family of proteins are cell-growth suppressors, associating with and influencing the biological activities of important cell cycle regulators in the S phase including monomeric non-phosphorylated cyclin-dependent kinase 2 (CDK2) and DNA polymerase alpha/primase. CDK2AP2 contains 5 distinct gt-ag introns. Transcription produces 7 different mRNAs, 6 alternatively spliced variants and 1 unspliced form. There are 2 non overlapping alternative las... | |||
TMPK-00828 |
Mucin-1/MUC1 Isoform Y Protein, Human, Recombinant (hFc)
PEMT,Episialin,Mucin1,PUM,KL-6,MUC-1,Mucin-1,H23AG,... |
Human | HEK293 Cells |
MUC1, the transmembrane glycoprotein Mucin 1, is usually found to be overexpressed in a variety of epithelial cancers playing an important role in disease progression. MUC1 isoforms such as MUC1/Y, which lacks the entire variable number of tandem repeat region, are involved in oncogenic processes by enhancing tumour initiation. MUC1/Y is therefore considered a promising target for the identification and treatment of epithelial cancers. | |||
TMPK-00392 |
FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi)
CD331,FGFR-1,FLT-2,BFGFR,N-sam,FGFR1 β (IIIc),bFGF-... |
Human | HEK293 Cells |
Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death. Overexpression of FGFR1 is observed in numerous tumors and thus constitutes an attractive molecular target for selective cancer treatment. FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 25.23 kDa and the accession numb... | |||
TMPK-00394 |
FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated
FGFR1 β (IIIc),N-sam,FLT-2,BFGFR,bFGF-R-1,CD331,FGF... |
Human | HEK293 Cells |
Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death. Overexpression of FGFR1 is observed in numerous tumors and thus constitutes an attractive molecular target for selective cancer treatment. FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 25.23 kDa and the ... | |||
TMPK-01371 |
IGFBP-7 Protein, Human, Recombinant (hFc)
RAMSVPS,TAF,IGFBPRP1,AGM,IBP7,MAC... |
Human | HEK293 Cells |
IGFBP-7, also known as Mac25/Angiomodulin (AGM), GFBP-rp1, tumor-derived adhesion factor (TAF) and prostacyclin-stimulating factor (PSF), is a secreted protein that contains three protein domain modules. Human IGFBP-rp1 cDNA encodes 282 amino acid (aa) residue precursor protein with a putative 26 aa signal peptide. IGFBP-7 binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. IGFBP-7 Protein, Human, Recombinant (hFc) is expres... | |||
TMPK-00395 |
FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated
FGF R1a,FGFR1 α,FGFR1 alpha,FGFR1 α (IIIc) |
Human | HEK293 Cells |
FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 42 kDa and the accession number is P11362-7. | |||
TMPK-00393 |
FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi)
FGFR1 α,FGFR1 alpha,FGF R1a,FGFR1 α (IIIc) |
Human | HEK293 Cells |
FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 42 kDa and the accession number is P11362-7. | |||
TMPY-06035 |
FGFR1 Protein, Human, Recombinant (alpha (IIIb), hFc)
KAL2,OGD,N-SAM,CEK,FLT2,HH2,FLG,CD331,BFGFR,HBGFR,F... |
Human | HEK293 Cells |
FGFR1 Protein, Human, Recombinant (alpha (IIIb), hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65.7 kDa and the accession number is P11362-7. |