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84

抑制剂 & 化合物

22

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T40549	PPA
	PPA serves as an ADC linker (US20060073528A1), facilitating the production of antibody-drug conjugates.
T19525	PPA-904	Others	Others
	PPA-904 is a specific phenothiazine photosensitizer,and used in photodynamic therapy.
T19525L	PPA-904 FA PPA-904 FA（30189-85-6 Free base）	Antibiotic	Microbiology/Virology
	PPA-904 FA 是一种阳离子光敏剂，具有广谱的抗菌活性，可用于光动力研究 (PDT) 研究，可用于研究慢性腿部溃疡和糖尿病足溃疡。
T40224	2',3'-cGAMP-C2-PPA 2',3'-cGAMP-C2-PPA
	2',3'-cGAMP-C2-PPA (45) is a cyclic di-nucleotide that acts as a STING agonist (US20210015941A1). It is a drug-linker conjugate for antibody-drug conjugates (ADC) used in the targeted treatment of cancer.
TP1960	(D)-PPA 1
	PD-1/PD-L1 interaction inhibitor. Binds to PD-L1 (Kd = 0.51 μM). Inhibits interaction at 1 mg/mL in flow cytometry. Inhibits tumor growth and prolongs survival time of mice in vivo.
T78222	(D)-PPA 1 TFA	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	(D)-PPA 1 TFA为一种抗水解D肽拮抗剂，同时也是有效的PD-1/PD-L1抑制剂。该化合物与PD-1结合亲和力达0.51 μM，且在体内外实验中表现有效。
T8672	2,2-BIS(2-HYDROXY-5-BIPHENYLYL)PROPANE BisOPP-A,双酚0PPA	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	2,2-BIS(2-HYDROXY-5-BIPHENYLYL)PROPANE 是针对促甲状腺激素受体（人）。
T78339	Human IgG4 (S228P) kappa, Isotype Control
	HumanIgG4(S228P) kappa, Isotype Control为人-鼠嵌合型单克隆抗体，作为humanIgG4(S228P)κ抗体的同型对照使用。
T13784	MTPPA M 5011	Others	Others
	MTPPA (M 5011) 是一种具有抗炎症和疼痛作用的化合物。
T16564	PPADS tetrasodium	P2X Receptor; Na+/Ca2+ Exchanger	Membrane transporter/Ion channel; Neuroscience
	PPADS tetrasodiuma 是一种有效的 P2X 受体拮抗剂，也是是豚鼠气道平滑肌 Na/Ca²⁺ 交换逆模式的抑制剂，对谷氨酸/NMDA毒性有神经保护作用。PPADS tetrasodiuma 抑制 P2X1、P2X-2、P2X-3 和 P2X-5。
T78337	Mouse IgG2a kappa, Isotype Control
	Mouse IgG2a kappa, Isotype Control 是鼠源IIgG2a kappa 抗体的同型抗体。
T20968	CyPPA	Potassium Channel; Dopamine Receptor	GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	CyPPA 是hSK2和hSK3的阳性调节剂，其EC50值分别为 5.6 μM 和14 μM。它对 hSK1 和 hIK 通道无活性。
T12529	Pparδ agonist 2	PPAR	DNA Damage/DNA Repair; Metabolism
	Pparδ agonist 2 is an agonist of PPARδ.
T62581	PPARγ agonist 6
	PPARγ agonist 6 (Compound 12) 是一种选择性 PPARγ 的有效激动剂。PPARγ agonist 6 具有潜力进行癌症疾病的研究。
T61743	PPARγ agonist 2
	PPARγ agonist 2 is a highly effective compound that acts as a partial agonist for PPARγ. It exhibits significant potential for utilization in metabolic disease research [1].
T60535	PPARα/γ agonist 1
	PPARα/γ agonist 1 是一种有效的双重 PPARα/γ部分激动剂，是用于研究血脂异常和糖尿病的有前途的化合物。PPARα/γ agonist 1 对 PPARα 和 PPARγ 的EC50值分别为 28 nM 和 69 nM。
T62554	PPARγ phosphorylation inhibitor 1
	PPARγ phosphorylation inhibitor 1 (Compound 10) 是一种有效的 PPARγ结合剂 (IC50: 24 nM)，具有抗糖尿病效果。PPARγ phosphorylation inhibitor 1 对 CDK5 介导的 PPARγ Ser273 磷酸化表现出抑制作用 (IC50: 160 nM)，且几乎无 PPARγ 激动作用。
T74464	m7GpppApG
	m7GpppApG 是一个三核苷酸，mRNA 5' 帽子的类似物，可以用于体外 RNA 合成。
T75009	PPARγ/GR modulator 1
	PPARγ/GR modulator 1 是一种口服活性的 PPARγ和糖皮质激素受体 (GR) 的双动激动剂，Ki 值分别为 3.3 和 33.6 μM。PPARγ/GR modulator 1 可用于研究代谢疾病，例如糖尿病。
T79182	PPARγ agonist 8	PPAR	DNA Damage/DNA Repair; Metabolism
	PPARγ agonist8，作为PPARγ的激动剂，能够诱导过氧化物酶体增殖反应元件(PPRE)-萤光素酶活性，其EC50值为0.2 μM。
T25976	Ppack HCl Ppack dihydrochloride,Fprmecl, dihydrochloride
	Ppack HCl is a peptide derivative that irreversibly and specifically suppresses thrombin-mediated platelet activation by binding with high affinity to the active site of thrombin (Ki: 0.24 nM). It has been utilized as an anticoagulant (100 μM) and to stud
T22497	2-MPPA	Others	Others
	glutamate carboxypeptidase II (GCP II) inhibitor
T126375	4-O-Methylepisappanol
	4-O-Methylepisappanol 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T126375。
T62205	Pparδ agonist 7
	Pparδ agonist 7 是一种 Pparδ 的有效激动剂。其中过氧化物酶体增殖物激活受体 (PPAR) 属于核内受体转录因子超家族，在体内代谢稳态、炎症、细胞生长和分化的调节中发挥着关键作用。Pparδ agonist 7 对非酒精性脂肪肝 (NAFLD) 表现出研究潜力。
T74472	m7GpppAmpG ammonium
	m7GpppAmpG ammonium 是一种三核苷酸 5′ 端帽类似物，对 RNA 的加帽率为 90%。
T78336	Mouse IgG1 kappa, Isotype Control
	MouseIgG1kappa Isotype Control 为 mouse IgG1κ 抗体的同型对照鼠源单克隆抗体。
T82159	Human IgG1 (K214R) kappa, Isotype Control
	HumanIgG1(K214R) kappa, Isotype Control为HumanIgG1(K214R)κ 抗体的人源化同型对照，属于人-鼠嵌合型抗体。
T23177	PPACK Dihydrochloride (71142-71-7 free base) PPACK Dihydrochloride	Others	Others
	PPACK Dihydrochloride is the dihydrochloride form of its active component PPACK (D-Phenylalanyl-L-prolyl-L-arginine chloromethyl ketone), a potent, selective, and irreversible inhibitor of thrombin that inhibits human α-thrombin with inhibition constant (
T81760	Mouse IgG1 (D265A) kappa, Isotype Control
	MouseIgG1(D265A) kappa, Isotype Control 为鼠源IgG1 κ类同型对照单克隆抗体，适用作为mouse IgG1(D265A)κ抗体的实验对照。
T63514	PPARγ agonist 1
	PPARγ agonist 1 是 PPARγ 的有效激动剂，能够高效的激活 hPPARγ ，并不引起完全激动，进而能够避免不良反应。PPARγ agonist 1 对代谢紊乱相关心血管疾病表现出研究潜力。
T126471	3'-Deoxy-4-O-methylepisappanol
	3'-Deoxy-4-O-methylepisappanol 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T126471。
T10505	PPARα-MO-1	PPAR	DNA Damage/DNA Repair; Metabolism
	PPARα-MO-1 is a potent modulator of PPARα.
T78612	APPA	Apoptosis	Apoptosis
	APPA为一种醛糖还原酶抑制剂，能够抑制大鼠多元醇途径，有效预防细胞凋亡及链脲佐菌素引发的糖尿病症状，显示出对糖尿病肾病(DN)研究的应用潜力。
T78244	Human IgG4 kappa, Isotype Control
	HumanIgG4kappa Isotype Control为人源化单克隆抗体，用作human IgG4κ抗体的同型对照。
T22727	DIPPA hydrochloride	Others	Others
	κ receptor antagonist
T23178	PPAHV	Others	Others
	vanilloid TRPV1 (VR1) receptor agonist
T126481	Sappanone B
	Sappanone B 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T126481。
T61465	PPARγ agonist 3
	PPARγ agonist 3, also known as Compound 18a, is a potent and selective agonist of PPARγ. This compound does not exhibit cytotoxicity towards both non-resistant and resistant cells. Notably, PPARγ agonist 3 demonstrates antitumor efficacy exclusively when co-administered with Imatinib [1].
T82161	Human IgG1 (D265A) kappa, Isotype Control
	HumanIgG1(D265A) kappa, Isotype Control是一种人鼠嵌合型抗体，用作HumanIgG1(D265A)κ抗体的同型对照。
T81756	Mouse IgG3 kappa, Isotype Control
	MouseIgG3kappa, Isotype Control为鼠源单克隆抗体，充当mouse IgG3κ抗体的同型对照。
T126391	Sappanol
	Sappanol 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T126391。
T20505	PPACK D-Phe-pro-arg CH2Cl
	PPACK is a synthetic peptide derivative. It also irreversibly and specifically inhibits thrombin-mediated platelet activation by binding with high affinity to the active site of thrombin (Ki = 0.24 nM).
T62646	Pparδ agonist 5
	Pparδ agonist 5 是一种选择性的、口服具有活力的 PPARδ 激动剂，其 EC50 为 0.335 μM，选择性好于 GW0742。Pparδ agonist 5 对体内骨密度和微结构的改善具有促进作用。
T73863	PPACK II
	PPACK II 是一种不可逆的特异性腺体和血浆激肽释放酶 (kallikreins) 抑制剂。
T78806	PPARδ agonist 9	PPAR	DNA Damage/DNA Repair; Metabolism
	PPARδ agonist9 (compound 21) 作为PPARδ激动剂，展现出EC50为3.6 nM的活性。在体内实验中，PPARδ agonist9能有效降低小鼠血清中MCP-1水平，并在LDLr-KO模型中显著抑制动脉粥样硬化的发展，其抑制率达50-60%。
T78341	Human IgG1 (F405L) kappa, Isotype Control
	HumanIgG1(F405L) kappa, Isotype Control为人-鼠嵌合型单克隆抗体，作为HumanIgG1(F405L)κ抗体的同型对照使用。
T78340	Human IgG1 (N297A) kappa, Isotype Control
	HumanIgG1(N297A) kappa, Isotype Control为具有人-鼠嵌合结构的抗体，作为HumanIgG1(N297A)κ 抗体的同型对照物。
T12528	Pparδ agonist 1	Others	Others
	Pparδ agonist 1 is an agonist of PPAR-δ(EC50 of 5.06 nM).
T10506	PPAR agonist 1	PPAR	DNA Damage/DNA Repair; Metabolism
	PPAR agonist 1 is an agonist of PPAR α/γ, used for reducing blood glucose, lipid levels, reducing body weight, and lowering cholesterol.
T25977	Ppack trifluoroacetate Ppack trifluoroacetate salt
	Ppack trifluoroacetate is a peptide derivative that irreversibly and specifically suppresses thrombin-mediated platelet activation by binding with high affinity to the active site of thrombin (Ki: 0.24 nM). It has been utilized as an anticoagulant (100 μM

化合物

Cat.No: T40549

Cat.No: T19525

Target: Others

Cat.No: T19525L

Synonym: PPA-904 FA（30189-85-6 Free base）

Target: Antibiotic

2',3'-cGAMP-C2-PPA

Cat.No: T40224

Synonym: 2',3'-cGAMP-C2-PPA

Cat.No: TP1960

(D)-PPA 1 TFA

Cat.No: T78222

Target: PD-1/PD-L1

2,2-BIS(2-HYDROXY-5-BIPHENYLYL)PROPANE

Cat.No: T8672

Synonym: BisOPP-A,双酚0PPA

Target: Thyroid hormone receptor(THR)

Human IgG4 (S228P) kappa, Isotype Control

Cat.No: T78339

Cat.No: T13784

Synonym: M 5011

Target: Others

PPADS tetrasodium

Cat.No: T16564

Target: P2X Receptor, Na+/Ca2+ Exchanger

Mouse IgG2a kappa, Isotype Control

Cat.No: T78337

Cat.No: T20968

Target: Potassium Channel, Dopamine Receptor

Pparδ agonist 2

Cat.No: T12529

Target: PPAR

PPARγ agonist 6

Cat.No: T62581

PPARγ agonist 2

Cat.No: T61743

PPARα/γ agonist 1

Cat.No: T60535

PPARγ phosphorylation inhibitor 1

Cat.No: T62554

Cat.No: T74464

PPARγ/GR modulator 1

Cat.No: T75009

PPARγ agonist 8

Cat.No: T79182

Target: PPAR

Cat.No: T25976

Synonym: Ppack dihydrochloride,Fprmecl, dihydrochloride

Cat.No: T22497

Target: Others

4-O-Methylepisappanol

Cat.No: T126375

Pparδ agonist 7

Cat.No: T62205

m7GpppAmpG ammonium

Cat.No: T74472

Mouse IgG1 kappa, Isotype Control

Cat.No: T78336

Human IgG1 (K214R) kappa, Isotype Control

Cat.No: T82159

PPACK Dihydrochloride (71142-71-7 free base)

Cat.No: T23177

Synonym: PPACK Dihydrochloride

Target: Others

Mouse IgG1 (D265A) kappa, Isotype Control

Cat.No: T81760

PPARγ agonist 1

Cat.No: T63514

3'-Deoxy-4-O-methylepisappanol

Cat.No: T126471

Cat.No: T10505

Target: PPAR

Cat.No: T78612

Target: Apoptosis

Human IgG4 kappa, Isotype Control

Cat.No: T78244

DIPPA hydrochloride

Cat.No: T22727

Target: Others

Cat.No: T23178

Target: Others

Cat.No: T126481

PPARγ agonist 3

Cat.No: T61465

Human IgG1 (D265A) kappa, Isotype Control

Cat.No: T82161

Mouse IgG3 kappa, Isotype Control

Cat.No: T81756

Cat.No: T126391

Cat.No: T20505

Synonym: D-Phe-pro-arg CH2Cl

Pparδ agonist 5

Cat.No: T62646

Cat.No: T73863

PPARδ agonist 9

Cat.No: T78806

Target: PPAR

Human IgG1 (F405L) kappa, Isotype Control

Cat.No: T78341

Human IgG1 (N297A) kappa, Isotype Control

Cat.No: T78340

Pparδ agonist 1

Cat.No: T12528

Target: Others

PPAR agonist 1

Cat.No: T10506

Target: PPAR

Ppack trifluoroacetate

Cat.No: T25977

Synonym: Ppack trifluoroacetate salt

Cat. No.	Product Name	Target	Signaling Pathways
T19535	Pyropheophorbide-a Ppa,焦脱镁叶绿酸-ALPHA	Others	Others
	Pyropheophorbide-a (Ppa) 是一种可用于肿瘤光动力疗法 (PDT) 的光敏剂。
T13589	Caesappanin C	Others	Others
	Caesappanin C 是一种联苯二聚体，提取自印度尼西亚 Caesalpinia sappan L. 的心材中，具有刺激骨形成和再生的潜力。它在体外显示出对原代成骨细胞的强增殖刺激活性。
T6560	Lappaconitine hydrobromide 氢溴酸高乌甲素,Lappaconite HBr,Allapinine	Others	Others
	Lappaconitine hydrobromide (Allapinine) 是天然生物碱类化合物，具有抗心律失常作用。
T2806	Lappaconitine 高乌甲素,(+)-Lappaconitine	P2X Receptor; Sodium Channel	Membrane transporter/Ion channel; Neuroscience
	Lappaconitine ((+)-Lappaconitine) 是从高乌头中分离得到的一种天然产物，可用于缓解疼痛的研究。
TMA1570	Sappanone A	NF-κB; Nrf2	Immunology/Inflammation; NF-κB
	Sappanone A 是一种高异黄烷酮，通过调节 Nrf2 和 NF-κB 表现出抗炎作用。Sappanone A 可以减轻卵清蛋白引起的哮喘中的过敏性气道炎症。
T6S1780	Protosappanin B 原苏木素B,Q-100961,FT-0689654	Apoptosis	Apoptosis
	Protosappanin B (Q-100961) 是从苏木中提取的一种多酚类天然产物，具有抗肿瘤作用。它通过激活 MDM2 依赖性泛素化过程诱导 p53 蛋白降解。它显著提高细胞活力，抑制细胞凋亡并上调生长相关蛋白 43 的表达。
T32570	Lappaconine 20-ethyl-1,14,16-trimethoxyaconitane-4,6,8-triol,O(sup 1)-Methyllappaconidine	Others	Others
	Lappaconine (20-ethyl-1,14,16-trimethoxyaconitane-4,6,8-triol) 衍生自去甲二萜生物碱。
TJS1779	Protosappanin A 原苏木素A,PTA	NADPH-oxidase; IL Receptor; IκB/IKK; TNF; NF-κB; TLR; ROS; COX; HIV Protease; JAK; NO Synthase; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome; Stem Cells
	Protosappanin A (PTA) 是从苏木中分离得到的免疫抑制成分和主要联苯化合物，通过下调 JAK2和 STAT3的磷酸化，抑制 JAK2/STAT3依赖的炎症通路。
TN5670	Protosappanin A dimethyl acetal
	Protosappanin A dimethyl acetal shows significant xanthine oxidase inhibitory activity in a concentration-dependent manner.
TN1072	Lappaol A	P-gp; JNK	MAPK; Membrane transporter/Ion channel; Neuroscience
	Lappaol A has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol A also has potential chemosensitizing activity, it may be candidates for developing novel adjuvant an
TN1246	3-Deoxysappanone B	Others	Others
	3-Deoxysappanone B has vasorelaxation effects, it can mediate endothelium- independent vasodilator action in rat thoracic aortic rings.
TN4411	Lappaol F	CDK; P-gp; JNK	Cell Cycle/Checkpoint; MAPK; Membrane transporter/Ion channel; Neuroscience
	1. Lappaol F has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. <br/> 2. Lappaol F has potential chemosensitizing activity, it may be candidates for developing novel adju
TN6462	Isolappaol C
	Isolappaol C 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6462，CAS号为 929905-15-7。
TN5673	10-O-Methylprotosappanin B
	10-O-Methylprotosappanin B是一种天然产物，属于豆科云实属，其产品编号为 TN5673，CAS号为 111830-77-4。10-O-Methylprotosappanin B可用作对照参考。
TMA2576	Episappanol	IL Receptor; TNF	Apoptosis; Immunology/Inflammation
	Episappanol has anti-inflammatory activity , it can significantly inhibit the secretion of the pro-inflammatory cytokines interleukin (IL-6) and tumor necrosis factor-alpha (TNF-α).
TN6461	Isolappaol A
	Isolappaol A 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6461，CAS号为 131400-96-9。
TN2923	3'-Deoxy-4-O-methylsappanol	Tyrosinase	Proteases/Proteasome
	3'-Deoxy-4-O-methylsappanol shows moderate cytotoxicities against cultured human melanoma HMV-II cells with the IC50 value of 872.0 uM ± 2.4.
TN2180	Sappanchalcone 苏木查耳酮	IL Receptor; BCL; TNF	Apoptosis; Immunology/Inflammation
	Sappanchalcone shows xanthine oxidase inhibitory activity, is a xanthine oxidase inhibitor.
TN1245	3-Deoxysappanchalcone	Others; Akt; mTOR	Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling
	3-Deoxysappanchalcone is an effective HO-1 inducer at the translational level.
TN3063	4-O-Methylsappanol	Antifection	Microbiology/Virology
	4-O-Methylsappanol shows activity against this fungus against Beauveria bassiana.
TN6463	Lappaol B
	Lappaol B 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6463，CAS号为 62359-60-8。
TN4410	Lappaol C	P-gp; JNK	MAPK; Membrane transporter/Ion channel; Neuroscience
	Lappaol C has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol C also has potential chemosensitizing activity, it may be candidates for developing novel adjuvant an

天然产物

Pyropheophorbide-a

Cat.No: T19535

Synonym: Ppa,焦脱镁叶绿酸-ALPHA

Target: Others

Cat.No: T13589

Target: Others

Lappaconitine hydrobromide

Cat.No: T6560

Synonym: 氢溴酸高乌甲素,Lappaconite HBr,Allapinine

Target: Others

Cat.No: T2806

Synonym: 高乌甲素,(+)-Lappaconitine

Target: P2X Receptor, Sodium Channel

Cat.No: TMA1570

Target: NF-κB, Nrf2

Protosappanin B

Cat.No: T6S1780

Synonym: 原苏木素B,Q-100961,FT-0689654

Target: Apoptosis

Cat.No: T32570

Synonym: 20-ethyl-1,14,16-trimethoxyaconitane-4,6,8-triol,O(sup 1)-Methyllappaconidine

Target: Others

Protosappanin A

Cat.No: TJS1779

Synonym: 原苏木素A,PTA

Target: NADPH-oxidase, IL Receptor, IκB/IKK, TNF, NF-κB, TLR, ROS, COX, HIV Protease, JAK, NO Synthase, STAT

Protosappanin A dimethyl acetal

Cat.No: TN5670

Cat.No: TN1072

Target: P-gp, JNK

3-Deoxysappanone B

Cat.No: TN1246

Target: Others

Cat.No: TN4411

Target: CDK, P-gp, JNK

Cat.No: TN6462

10-O-Methylprotosappanin B

Cat.No: TN5673

Cat.No: TMA2576

Target: IL Receptor, TNF

Cat.No: TN6461

3'-Deoxy-4-O-methylsappanol

Cat.No: TN2923

Target: Tyrosinase

Cat.No: TN2180

Synonym: 苏木查耳酮

Target: IL Receptor, BCL, TNF

3-Deoxysappanchalcone

Cat.No: TN1245

Target: Others, Akt, mTOR

4-O-Methylsappanol

Cat.No: TN3063

Target: Antifection

Cat.No: TN6463

Cat.No: TN4410

Target: P-gp, JNK

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