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Cat. No. | Product Name | ||
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L6750 | 活血化瘀中药单体库 | 580 compounds | |
580种来源于常见活血化瘀中药的单体化合物,是药物开发、药理研究等领域的有效工具。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T39632 |
PB succiniMidyl ester
PB succiniMidyl ester,Ocean Blue, SE |
||
PB succiniMidyl ester (Ocean Blue, SE) is a fluorophore with the λ excitation/emission of ~405/455 nm. | |||
T9159 |
PBT-1033
PB 1033,PBT1033,PBT-2,PBT 2,PBT2 |
Others | Others |
PBT-1033 (PBT-2) 是一种潜在的神经保护剂,用于治疗阿尔茨海默病和亨廷顿病。 | |||
T1764 |
Adezmapimod
PB 203580,4-(4-氟苯基)-2-(4-甲基亚磺酰基苯基)-5-(4-吡啶基)-1H-咪唑,RWJ 64809,SB203580 |
Mitophagy; p38 MAPK; Autophagy | Autophagy; MAPK |
Adezmapimod (SB 203580) 是一种 p38 MAPK 抑制剂 (IC50=0.3-0.5 μM),具有选择性和 ATP 竞争性。Adezmapimod 具有自噬和线粒体自噬的激活活性。Adezmapimod 显示出比 PKB、LCK 和 GSK-3β 高 100 倍以上的选择性。 | |||
T35888 |
PB1
|
||
PB1 is a highly-effective intracellular disulfide reducing agent with notable attributes such as excellent cell permeability, the capacity to generate a substantial intracellular concentration gradient, and remarkable stability. It serves as a borane-protected TCEP (tris(2-carboxyethyl)phosphine) analogue. PB1 demonstrates the potential to enhance the survival of retinal ganglion cells following axotomy in vitro at concentrations in the nanomolar and picomolar range. Consequently, PB1 has proven... | |||
T31799 |
Flavopereirine
PB 100,PB-100,PB100 |
||
Flavopereirine is a beta-carboline alkaloid. | |||
T35889 |
PB2
|
||
PB2, a tris(2-carboxyethyl)phosphine (TCEP) analogue, enhances the survival of retinal ganglion cells (RGCs) following axotomy in vitro. Even at nanomolar and picomolar concentrations, PB2 demonstrates pronounced efficacy in promoting RGC survival. Notably, PB2 exhibits superior permeability compared to TCEP. Serving as a potent reducing agent, PB2 provides robust neuroprotection for RGCs[1]. | |||
T39176 |
PB28
|
||
PB28 is a cyclohexylpiperazine derivative that functions as a potent and highly selective agonist of the sigma 2 (σ2) receptor, exhibiting a Ki (binding affinity) of 0.68 nM. At the same time, PB28 acts as an antagonist of the sigma 1 (σ1) receptor, with a Ki of 0.38 nM. PB28 demonstrates a lower affinity for other receptors. It effectively inhibits electrically evoked twitch in both the guinea pig bladder (EC50 value of 2.62 μM) and ileum (EC50 value of 3.96 μM). Moreover, PB28 exhibits the abi... | |||
T6949 |
PLX7904
PB04 |
Raf | MAPK |
PLX7904 (PB04) 是一种有效且选择性的悖论破坏剂 RAF 抑制剂,可抑制突变 BRAF 黑色素瘤细胞中 ERK1/2 的激活。在表达突变体 RAS 的细胞中,对 BRAFV600E 的IC50值约为 5 nM。 | |||
T23122 |
PB28 dihydrochloride
PB 28 dihydrochloride |
Others | Others |
σ2 receptor agonist | |||
T27970 |
Mabuterol free base
Mabuterol,PB 868Cl |
Others | Others |
Mabuterol is a selective agonist of β2 adrenoreceptor with no beta 1-stimulation. Mabuterol inhibited the positive inotropic effect of isoprenaline at 10(-7) g/ml and decreased the maximum driving frequency at 3 X 10(-6) g/ml. Mabuterol was 3 times more p | |||
T78552 |
PB118
|
||
PB118是一种新型组蛋白去乙酰化酶 6(HDAC6)抑制剂,具备穿越血脑屏障的能力,可用于AD治疗。PB118 对 HDAC6 的 IC50 为 5.6 nM。 | |||
T82898 |
Bentracimab
PB 2452,MEDI 2452 |
||
Bentracimab (PB 2452) 是高度亲和性的中和单克隆抗体,专门结合于Ticagrelor及其主要活性代谢产物。该抗体能迅速逆转Ticagrelor的抗血小板功能。 | |||
T71803 |
Mabuterol hydrochloride
|
||
Mabuterol hydrochloride is a selective β2 adrenoreceptor agonist. Mabuterol has a specific effect on beta 2-adrenoceptors with no beta 1-stimulation. | |||
T16948 |
Suclofenide
PB385,Neosulfalepsine,琥氯非尼 |
Others | Others |
Suclofenide 是一种苯磺酰胺衍生物,可作为抗惊厥和抗癫痫剂。在临床前模型中,它对小鼠电击和戊四唑诱导的惊厥表现出强大的抗惊厥活性。亚致死毒性表现为嗜睡、肌阵挛抽搐和腹泻。 | |||
T77884 |
PB038
|
||
PB038为一种ADC药物,由可降解的PEG linker及毒素分子依喜替康(Exatecan)构成的偶联物。 | |||
T81536 |
PB089
|
||
PB089是一种ADC(抗体药物偶联物),由Exatecan毒素分子与一种可降解的PEG linker偶联而成。 | |||
T78969 | PB131 | HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
PB131为选择性HDAC6抑制剂,能穿透血脑屏障且显示出高结合亲和性(IC50: 1.8 nM)。该化合物展现出显著的抗炎活性,适用于炎症特别是神经炎症的研究领域。 | |||
T15014 |
CTPB
|
Histone Acetyltransferase | Chromatin/Epigenetic |
CTPB 是一种有效的 p300 组蛋白乙酰转移酶 (HAT) 活化剂,可用于制备毛发生长促进剂和/或脱发治疗剂。 | |||
T22513 |
4-PPBP maleate
|
Sigma receptor; NMDAR | GPCR/G Protein; Neuroscience |
4-PPBP maleate 是一种有效的 σ1 受体(配体)激动剂。4-PPBP maleate 在Xenopus oocytes 表达的情况下可被认为是一种具有选择性、非竞争性的 NR1a/2B NMDA 受体 拮抗剂。4-PPBP maleate 具有神经保护特性。 | |||
TP1844L |
Small Cardioactive Peptide B SCPB acetate
Small Cardioactive Peptide B SCPB acetate(84746-43-0 free base) |
Others | Others |
Small Cardioactive Peptide B SCPB acetate (Small Cardioactive Peptide B SCPB acetate (84746-43-0 free base)) 是一种神经活性肽,可刺激心脏和鳃组织颗粒部分的腺苷酸环化酶活性,EC50 分别为 0.1 和 1.0 μM。 | |||
T2071 |
MCOPPB triHydrochloride
MCOPPB trihydrochlride,MCOPPB 3HCl |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
MCOPPB triHydrochloride (MCOPPB 3HCl) 是一种伤害感受肽受体激动剂,pKi 为10.07。 | |||
T22641 |
CDPPB
|
GluR | Neuroscience |
CDPPB 是选择性和脑渗透性的代谢型谷氨酸受体亚型5 (mGluR5) 阳性变构的调节剂,在表达人类 mGluR5 的中国仓鼠卵巢细胞中的 EC50值为 27 nM。它为开发抗精神病药提供了一种可能性。 | |||
T17148 |
TPPB
|
PKC | Chromatin/Epigenetic; Cytoskeletal Signaling |
TPPB 是可渗透细胞的苯并内酰胺衍生蛋白的激酶 C 激活剂,Ki 值为11.9 nM。 | |||
T12580 |
PTUPB
|
COX; Epoxide Hydrolase | Immunology/Inflammation; Metabolism; Neuroscience |
PTUPB 是强效的sEH(IC50:0.9 μM)和COX-2(IC50:1.26 μM)的双向抑制剂。 | |||
T70604 |
ClpB-IN-1
|
Antibacterial | Microbiology/Virology |
ClpB-IN-1 是一种潜在的抗菌剂。ClpB-IN-1 是一种有效的 ClpB 抑制剂。 | |||
T60155 |
PBRM1-BD2-IN-7
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
PBRM1-BD2-IN-7 是一种选择性和细胞活性的 PBRM1 溴化域抑制剂。PBRM1-BD2-IN-7 对 PBRM1-BD2 具有抑制活性,IC50 值为 0.29 μM。PBRM1-BD2-IN-7 可用于癌症的研究。 | |||
T60158 |
PBRM1-BD2-IN-3
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
PBRM1-BD2-IN-3 (compound 12) 是一种有效的 PBRM1-BD2 抑制剂,IC50 为 1.1 μM。PBRM1-BD2 Inhibitor 可用于抗癌研究。 | |||
T11092 |
DPBQ
ZINC1620467,2,3-Diphenylbenzo[g]quinoxaline-5,10-dione |
p53 | Apoptosis |
DPBQ (ZINC1620467) 是一种 p53 的激活剂。DPBQ 以多倍体特异性方式激活并诱导凋亡 (apoptosis),但不会抑制拓扑异构酶或结合 DNA。 | |||
T7638 |
NPPB
|
Chloride channel | Membrane transporter/Ion channel |
NPPB 是外向整流氯化物通道阻断剂,IC50 为 80 nM。 | |||
T1288 |
TTNPB
AGN191183,Arotinoid acid,Ro 13-7410,AGN-191183,Ro 13-7410 |
Apoptosis; Retinoid Receptor; Autophagy | Apoptosis; Autophagy; Metabolism |
TTNPB (Ro 13-7410,AGN-191183) 是一种RAR 激动剂。在使用人RARs 进行竞争性结合实验中,作用于RARα,RARβ和RARγ,IC50分别为 5.1 nM,4.5 nM 和 9.3 nM。 | |||
T60157 |
PBRM1-BD2-IN-8
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
PBRM1-BD2-IN-8 (compound 34) 是一种强效的 PBRM1 Bromodomain 抑制剂 (PBRM1-BD2 Kd=4.4 μM, PBRM1-BD2 IC50=0.16 μM; PBRM1-BD5 Kd=25 μM),其具有抗癌活性。 | |||
T16436 |
PBOX 6
PBOX-6 |
Apoptosis | Apoptosis |
PBOX 6 是一种 pyrrolo-1,5-benzoxazepine (PBOX) 化合物,具有抗癌抗肿瘤活性,可在体外抑制乳腺癌细胞的生长,在白血病细胞中通过 c-Jun NH2 末端激酶依赖性磷酸化、 Bcl-2 和 Bcl-XL 的失活发生选择性诱导细胞凋亡。 | |||
T60159 |
PBRM1-BD2-IN-5
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
PBRM1-BD2-IN-5 是一种有效的 PBRM1 Bromodomain 抑制剂,对 PBRM1-BD2 和 PBRM1-BD5 的 Kd 分别为 1.5 μM 和 3.9 μM,对 PBRM1-BD2 的 IC50 为 0.26 μM。PBRM1-BD2-IN-5 减少细胞裂解物中 PBAF 复合体全长 PBRM1 与乙酰化组蛋白肽的结合。PBRM1-BD2-IN-5 可用于抗癌研究。 | |||
T1760 |
TBPB
|
AChR | Neuroscience |
TBPB 是变构 M1 mAChR 激动剂,EC50值为289nM,可在大鼠中调节淀粉样蛋白加工并产生抗精神病样活性。 | |||
T13718 |
H-Arg(Pbf)-OMe hydrochloride
|
Others | Others |
H-Arg(Pbf)-OMe hydrochloride 是一种精氨酸类似物。 | |||
T12249 |
NPB
Alpha-NPB |
Others | Others |
NPB (Alpha-NPB) 是一种特异且有效的抑制 BAD Ser99 磷酸化的抑制剂, IC50为 0.41 μM。 | |||
T24836 |
ß-pBrPh-Glc
Beta-pBrPh-Glc,ßpBrPhGlc,p-Bromophenyl-beta-D-glucopyranoside,p-Bromophenyl-ß-D-glucopyranoside |
Antioxidant | oxidation-reduction |
ß-pBrPh-Glc (ßpBrPhGlc) 是冰块再结晶的抑制剂,控制细胞外冰的生长,对细胞内冰的再结晶有抑制作用。ß-pBrPh-Glc 可被当作低温保存剂 ,可能具有抗氧化活性。 | |||
T7905 |
PBD-150
|
Beta Amyloid | Neuroscience |
PBD-150 是一种人谷氨酰胺酰基环化酶 Y115E-Y117E 变体的抑制剂,其 Ki=490 nM。 | |||
T16435 |
PBIT
|
Histone Demethylase; Histone Methyltransferase | Chromatin/Epigenetic |
PBIT 是一种特异性 Jumonji/AT 富集互作结构域 1 抑制剂,抑制JARID1A 和JARID1C,IC50分别为 6 和 4.9 μM。它抑制JARID1B(KDM5B 或PLU1) 组蛋白去甲基化酶,IC50值约为 3 μM。 | |||
T60156 |
PBRM1-BD2-IN-2
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
PBRM1-BD2-IN-2 是一种选择性和细胞活性的 PBRM1 溴化域抑制剂。PBRM1-BD2-IN-2 对 PBRM1-BD2 具有结合亲和力和抑制活性, Kd 和 IC50 值分别为 9.3 μM 和 1.0 μM。PBRM1-BD2-IN-2 可用于癌症的研究。 | |||
T8794 |
4-MMPB
15-Lipoxygenase Inhibitor 1 |
Apoptosis; Others; Lipoxygenase | Apoptosis; Metabolism; Others |
4-MMPB (15-Lipoxygenase Inhibitor 1) 是一种选择性15-脂氧合酶抑制剂,其 IC50值为 18 μM,具有前列腺癌的研究潜力。它对大豆 15-脂氧合酶和人 15-脂氧合酶-1 的 IC50 分别为 19.5 μM 和 19.1 μM。 | |||
T33803 | OPB-111077 | ||
OPB-111077 is an inhibitor of one or more signal transducers and activators of transcription (STAT) proteins. | |||
T18700 |
SPB
|
Others | Others |
SPB is a potent anti-inflammatory drug-linker conjugate for Antibody-Drug Conjugates (ADC), utilizing Xanthotoxol connected through the ADC linker. | |||
T75811 |
PBP10 TFA
|
||
PBP10是一种细胞通透性和选择性的gelsolin衍生的肽抑制剂,针对甲酰基肽受体2(FPR2)具有较高选择性,相较于FPR1更为优选。该化合物为N端偶联罗丹明的10个氨基酸肽,对革兰氏阳性及革兰氏阴性菌均展现出杀菌活性,同时能够抑制微生物诱导的炎症反应。 | |||
T73195 |
EAPB 02303
|
||
EAPB 02303 是一种微管破坏剂和抑制剂。EAPB 02303 诱导有丝分裂停止和纺锤体组装损伤。因此,EAPB 02303 诱导细胞凋亡 (apoptosis) 并表现出抗肿瘤活性。EAPB 02303 在较低浓度下也表现出与紫杉醇 的强协同作用。 | |||
T19943 |
SMPB Crosslinker
SMPB Cross linker,SMPB Cross-linker |
||
SMPB crosslinker is a heterobifunctional protein crosslinking reagent that is reactive toward sulfhydryl and amino groups. The SMPB protein crosslinker is an extended chain length analog of MBS crosslinker. SMPB crosslinker's spacer arm is non-cleavable. | |||
T26025 |
R(+)-6-Bromo-APB HBr
R(+) 6 Bromo APB hydrobromide,R(+)-6-Bromo-APB hydrobromide,R(+) 6 Bromo APB HBr |
||
R(+)-6-Bromo-APB HBr is used as a D1 Dopamine receptor agonist. | |||
T61364 |
LmCPB-IN-1
|
||
LmCPB-IN-1 (compound 35) is a highly effective and reversible covalent inhibitor of Leishmania mexicana cysteine protease B (LmCPB). It exhibits a strong binding affinity with a pK i value of 9.7 [1]. | |||
T69447 |
APBC
|
||
APBC is a novel PD-L1 inhibitor, effectively interrupting the PD-1/PD-L1 interaction by directly binding to PD-L1, presenting the KD and IC50 values at low-micromolar level, displaying superior antitumor efficacy in hPD-L1 knock-in B16F10-bearing mouse model without the induction of observable liver toxicity. | |||
T71174 |
PBT434 HBr
|
||
PBT434 is a novel, brain-penetrant, small molecule inhibitor of α-synuclein aggregation. In transgenic animal models of Parkinson disease (A53T) and MSA (PLP-α-Syn), PBT434 reduced α-synuclein aggregation, preserved neurons and improved motor function. Glial cell inclusions were also reduced in a murine MSA model. PBT434 is thought to act by redistributing reactive iron across membranes, thereby blocking intracellular protein aggregation and oxidative stress. The affinity of PBT434 for iron is g... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T26366 |
Dehydroepiandrosterone sulfate
PB 005,PB005,Prasterone sulfate,DHEA sulfate,DHEAS,PB-005 |
Others | Others |
Dehydroepiandrosterone sulfate (PB-005) 影响神经元的迁移、树突的分枝和新突触的形成。 | |||
T2S0633 |
Raspberry ketone
Oxyphenalon,Rasketone,Aloenin,4-(4-Hydroxyphenyl)-2-butanone,p-Hydroxybenzyl acetone,Frambinone,覆盆子酮 |
PPAR | DNA Damage/DNA Repair; Metabolism |
Raspberry ketone (p-Hydroxybenzyl acetone) 是覆盆子中主要的芳香族天然产物,主要用作化妆品的香料和食品增味剂,也可作 PPAR-α激动剂。 | |||
T8244 |
Raspberry ketone glucoside
覆盆子酮葡糖苷,树莓苷,覆盆子酮葡萄糖甙 |
Others | Others |
Raspberry ketone glucoside 是一种山莓果实中的天然产物。它能够抑制黑色素的合成。 | |||
TN1365 |
Albaspidin AP
|
Fatty Acid Synthase | Metabolism |
Albaspidin-AP, -PP, -PB inhibit Fatty acid synthase (FAS) with IC50 values ranging from 23.1+/-1.4 to 71.7+/-3.9 microM, they could be considered to be a promising class of FAS inhibitors, and FAS is emerging as a potential therapeutic target to treat can |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00860 |
HTN3 Protein, Human, Recombinant
HTN3,Histidine-rich protein 3,Histatin-3,Basic histidine-ric... |
Human | E. coli |
HTN3 belongs to the histatin/statherin family. Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. Post-translational proteolytic processing results in many histatins: e.g., histatins 4-6 are derived from histatin 3 by proteolysis. Histatins 1 and 3 are primary products of HIS1and HIS2 alleles, respectively. Histatins are be... | |||
TMPY-04230 |
HAI-2/SPINT2 Protein, Human, Recombinant (His)
PB,DIAR3,HAI2,Kop,HAI-2,serine peptidase inhibitor,... |
Human | HEK293 Cells |
HAI-2/SPINT2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.6 kDa and the accession number is O43291-1. | |||
TMPY-00474 |
HAI-2/SPINT2 Protein, Human, Recombinant (hFc)
PB,serine peptidase inhibitor, Kunitz type, 2,Kop,H... |
Human | HEK293 Cells |
HAI-2/SPINT2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.9 kDa and the accession number is O43291-1. | |||
TMPJ-01470 |
SCF Protein, Human, Recombinant
Mast Cell Growth Factor,c-Kit ligand,KITLG,MGF,Stem Cell Fac... |
Human | E. coli |
Stem Cell Factor (SCF) is a hematopoietic growth factor that exerts its activity at the early stages of hematopoiesis. SCF stimulates the proliferation of myeloid, erythroid, and lymphoid progenitors in bone marrow cultures and has been shown to act synergistically with colony stimulating factors. | |||
TMPH-01186 |
CYP2C9 Protein, Human, Recombinant (His & Myc)
CYP2C10,Cytochrome P450 2C9,S-mephenytoin 4-hydroxylase,(R)-... |
Human | E. coli |
CYP2C9 Protein, Human, Recombinant (His & Myc) is expressed in E. coli. | |||
TMPH-00964 |
ATP5PB Protein, Human, Recombinant (His & Myc)
ATP synthase proton-transporting mitochondrial F(0) complex ... |
Human | E. coli |
ATP5PB Protein, Human, Recombinant (His & Myc) is expressed in E. coli. | |||
TMPJ-01462 |
IL-15RA & IL-15 Protein, Human, Recombinant - PBS Lyophilized (hFc)
IL15,IL15RA&IL15,IL-15,Interleukin-15,IL-15 Receptor α & IL-... |
Human | HEK293 Cells |
IL15RA is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells.IL-15 is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 ... | |||
TMPY-05033 |
5T4/TPBG Protein, Human, Recombinant (aa 60-345, His)
5T4AG,trophoblast glycoprotein,WAIF1,M6P1,5T4 |
Human | HEK293 Cells |
Trophoblast glycoprotein (TPBG), also known as 5T4, is the therapeutic target of several anticancer agents currently in clinical development, largely due to its high expression in tumors and low expression in normal adult tissues. 5T4/TPBG Protein, Human, Recombinant (aa 60-345, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 33.1 kDa and the accession number is Q13641. | |||
TMPH-02992 |
FbpB Protein, Mycobacterium kansasii, Recombinant (His & Myc & SUMO)
|
Mycobacterium kansasii | E. coli |
FbpB Protein, Mycobacterium kansasii, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 50.6 kDa and the accession number is P21160. | |||
TMPH-00648 |
LapB Protein, E. coli, Recombinant (His)
|
E. coli | E. coli |
Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane. | |||
TMPH-03643 |
TmpB Protein, Treponema phagedenis, Recombinant (His & Myc)
|
Treponema phagedenis | E. coli |
Tmp may serve as a porin or transport protein for large molecules. TmpB Protein, Treponema phagedenis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 47.4 kDa and the accession number is P29720. | |||
TMPY-06810 |
SFTPB Protein, Human, Recombinant (His)
SFTP3,SMDP1,PSP-B,SFTB3,SP-B |
Human | CHO Cells |
Pulmonary surfactant-associated protein B, also known as SFTPB and SP-B, contains one saposin A-type domain and three saposin B-type domains. SP-B is produced primarily by alveolar type II cells (AEC2) but also by nonciliated respiratory epithelial cells lining distal portions of the respiratory tract. Its secretion promotes alveolar homeostasis, stabilizing lipid layers and lowering surface tension at the air-liquid interface in the peripheral air spaces. Alveolar SP-B influences surfactant for... | |||
TMPY-05553 |
CENPB Protein, Human, Recombinant (His)
|
Human | Baculovirus Insect Cells |
CENPB Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 67.5 kDa and the accession number is P07199. | |||
TMPY-06214 |
5T4/TPBG Protein, Mouse, Recombinant (hFc)
trophoblast glycoprotein,AW495680,5T4,WAIF1 |
Mouse | HEK293 Cells |
Trophoblast glycoprotein (TPBG), also known as 5T4, is the therapeutic target of several anticancer agents currently in clinical development, largely due to its high expression in tumors and low expression in normal adult tissues. 5T4/TPBG Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 62.5 kDa and the accession number is Q9Z0L0. | |||
TMPY-06191 |
5T4/TPBG Protein, Mouse, Recombinant (His)
trophoblast glycoprotein,WAIF1,5T4,AW495680 |
Mouse | HEK293 Cells |
Trophoblast glycoprotein (TPBG), also known as 5T4, is the therapeutic target of several anticancer agents currently in clinical development, largely due to its high expression in tumors and low expression in normal adult tissues. 5T4/TPBG Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.2 kDa and the accession number is Q9Z0L0. | |||
TMPH-00170 |
PBP 4 Protein, Bacillus subtilis, Recombinant (His & SUMO)
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Bacillus subtilis | E. coli |
Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) (Probable). Has a partially redundant function with PBP-2A (pbpA) during spore outgrowth. PBP 4 Protein, Bacillus subtilis, Recombinant (His & SUMO) is expressed in E. coli expression system with N... | |||
TMPJ-00932 |
PBLD Protein, Human, Recombinant (His)
MAWBP,MAWD-Binding Protein,PBLD,MAWDBP,Unknown Prot... |
Human | E. coli |
Phenazine Biosynthesis-Like Domain-Containing protein (PBLD) belongs to the phenazine biosynthesis-like protein (PhzF) family, which is expressed in most tissues. PBLD takes part in the MAPK signaling pathway, and is involved in multiple basic cellular functions. The expression of PBLD can be increased in several disease processes, including insulin resistance, folate deficiency and hypotension. | |||
TMPH-01490 |
HLA-DPB1 Protein, Human, Recombinant (His)
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Human | E. coli |
HLA-DPB1 Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPH-03718 |
YopB Protein, Yersinia enterocolitica, Recombinant (His)
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Yersinia enterocolitica | E. coli |
Plays a role in virulence. | |||
TMPY-04547 |
PBK/TOPK Protein, Human, Recombinant (His)
HEL164,Nori-3,CT84,TOPK,PDZ binding kinase,SPK |
Human | Baculovirus Insect Cells |
PDZ binding kinase (PBK), also known as TOPK (T-LAK cell-originated protein kinase), is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family, and has all the characteristic protein kinase subdomains and a C-terminal PDZ-binding T/SXV motif. PBK is expressed in the testis restrictedly expressed in outer cell layer of seminiferous tubules, as well as placenta. PBK may be enrolled in the activation of lymphoid cells and support testicular fun... | |||
TMPJ-01374 |
UPB1 Protein, Human, Recombinant (His)
β-Ureidopropionase,Beta-Alanine Synthase,β-Alanine Synthase,... |
Human | E. coli |
β-Ureidopropionase is a cytoplasmic protein which belongs to the CN hydrolase family of BUP subfamily. β-Ureidopropionase binds one zinc ion per subunit, catalyzes the last step in the pyrimidine degradation pathway. β-Ureidopropionase can convert N-carbamyl-beta-aminoisobutyric acid and N-carbamyl-beta-alanine to beta-aminoisobutyric acid and beta-alanine, ammonia and carbon dioxide, respectively. The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidi... | |||
TMPH-03509 |
Simian immunodeficiency virus (SIV) (isolate PBj14/BCL-3) Vpx Protein (His & SUMO)
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SIV | E. coli |
Simian immunodeficiency virus (SIV) (isolate PBj14/BCL-3) Vpx Protein (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 28.9 kDa and the accession number is P19508. | |||
TMPH-01979 |
SFTPB Protein, Human, Recombinant
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Human | P. pastoris (Yeast) |
Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter. SFTPB Protein, Human, Recombinant is expressed in yeast. The predicted molecular weight is 8.7 kDa and the accession number is P07988. | |||
TMPJ-01375 |
HSPB7 Protein, Human, Recombinant (His)
Pregnancy specific β-1-glycoprotein 2,PSG2,PSBG2,pregnancy-s... |
Human | E. coli |
HSPB7 Protein, Human, Recombinant (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 20-25 KDa and the accession number is Q9UBY9. | |||
TMPJ-00269 |
5T4/TPBG Protein, Human, Recombinant (mFc)
TPBG,5T4 Protein,M6P1 Protein,5T4AG Protein,WAIF1 P... |
Human | HEK293 Cells |
5T4/TPBG Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 80-110 KDa and the accession number is Q13641. | |||
TMPJ-00722 |
APBA3 Protein, Human, Recombinant (His)
Neuronal Munc18-1-Interacting Protein 3,Neuron-Specific X11L... |
Human | E. coli |
Amyloid β A4 Precursor Protein-Binding Family A Member 3 (APBA3) is an adapter protein that belongs to the X11 family. APBA3 contains 2 PDZ (DHR) domains and 1 PID domain and interacts with the Alzheimer's disease amyloid precursor protein.. APBA3 is believed to be involved in signal transduction processes. Unlike X11-α and -β which are generally neuronal proteins, APBA3 is widely expressed in all tissues examined with lower levels in brain and testis. It binds to the cytoplasmic domain of amylo... | |||
TMPH-02380 |
RPB5 Protein, Kluyveromyces marxianus, Recombinant (His)
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Kluyveromyces marxianus | E. coli |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol... | |||
TMPJ-01411 |
HSPB11 Protein, Human, Recombinant (His)
PP25,Placental Protein 25,Heat Shock Protein β-11,Heat Shock... |
Human | E. coli |
Heat Shock Protein β-11 (HSPB11) is a stress-responsive protein that is required to deal with proteotoxic stresses. HSPB11 is composed of an IFT complex B composed of IFT88, IFT57, TRAF3IP1, IFT52, IFT27, HSPB11 and IFT20 and is detected in placenta. HSPB11 has beeb shown to form oligomeric complexes and prevent the aggregation of in vitro denaturated aldolase and glyceraldehyde-3-phosphate dehydrogenase in accordance with the chaperone model of HSPB1 and HSPB5. HSPB11 overexpression protected a... | |||
TMPH-00407 |
PBP1a Protein, Clostridium botulinum, Recombinant (His & SUMO)
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Clostridium botulinum | E. coli |
PBP1a Protein, Clostridium botulinum, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPH-00505 |
RPB1 Protein, Drosophila melanogaster, Recombinant (His)
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Fruit fly | P. pastoris (Yeast) |
RPB1 Protein, Drosophila melanogaster, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 33.6 kDa and the accession number is P04052. | |||
TMPK-00270 |
TPBG/5T4 Protein, Human, Recombinant (His & Avi), FITC-Labeled
WAIF1,TPBG,5T4AG,5T4,M6P1 |
Human | HEK293 Cells |
The oncofetal tumor-associated antigen 5T4 (TBGP) has been linked with CSC properties in several different malignancies. 5T4 has functional attributes that are relevant to the spread of tumors including through EMT, CXCR4/CXCL12, Wnt, and Hippo pathways which may all contribute through the mobilization of CSCs. TPBG/5T4 Protein, Human, Recombinant (His & Avi), FITC-Labeled is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 38.2 kDa and the accession numb... | |||
TMPH-03392 |
5T4/TPBG Protein, Rat, Recombinant (His & SUMO)
Wnt-activated inhibitory factor 1,Trophoblast glycoprotein,T... |
Rat | E. coli |
May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. 5T4/TPBG Protein, Rat, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 51.8 kDa and the accession number is Q5PQV5. | |||
TMPJ-00649 |
CPB2 Protein, Human, Recombinant (His)
CPB2,CPU,TAFI,pCPB,Carboxypeptidase B2,Pla... |
Human | HEK293 Cells |
Carboxypeptidase B2 (CPB2) is a secreted enzyme that belongs to the peptidase M14 family. CPB2 is synthesized by the liver and circulates in the plasma as a plasminogen-bound zymogen by the liver and circulates in the plasma as a plasminogen-bound zymogen. CPB2 cleaves C-terminal arginine or lysine residues from biologically active peptides, such as kinins or anaphylatoxins, in the circulation regulating their activities. CPB2 also down-regulates fibrinolysis by removing C-terminal lysine residu... | |||
TMPH-03044 |
PBP1a Protein, MenB, Recombinant (His & SUMO)
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MenB | E. coli |
Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits). | |||
TMPY-04559 |
CDC42BPB Protein, Human, Recombinant (His & GST)
CDC42 binding protein kinase beta (DMPK-like),MRCKB,CDC42 bi... |
Human | Baculovirus Insect Cells |
CDC42BPB is a member of the serine / threonine protein kinase family that contains a Cdc42 / Rsc-binding p21 binding domain similar to that of PAK kinase. The kinase domain of this protein is related to the myotonic dystrophy kinase related ROK and this kinase may have functions in downstream regulating of Cdc42 in cytoskeletal recognization. It has been reported that the CDC42BPB protein take part in regulating numerous cellular functions by binding to members of a serine / threonine protein ki... | |||
TMPH-00928 |
APBA2 Protein, Human, Recombinant (E. coli, His & Myc)
Neuronal Munc18-1-interacting protein 2 (Mint-2),Amyloid-bet... |
Human | E. coli |
APBA2 Protein, Human, Recombinant (E. coli, His & Myc) is expressed in E. coli. | |||
TMPY-06317 |
5T4/TPBG Protein, Human, Recombinant (aa 1-355, His)
trophoblast glycoprotein,WAIF1,5T4AG,M6P1,5T4 |
Human | HEK293 Cells |
Trophoblast glycoprotein (TPBG), also known as 5T4, is the therapeutic target of several anticancer agents currently in clinical development, largely due to its high expression in tumors and low expression in normal adult tissues. 5T4/TPBG Protein, Human, Recombinant (aa 1-355, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.15 kDa and the accession number is NP_006661.1. | |||
TMPH-00681 |
ssPB Protein, E. coli O157:H7, Recombinant (His)
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E. coli | E. coli |
Seems to act in concert with SspA in the regulation of several proteins during exponential and stationary-phase growth. The exact function of SspB is not yet known. | |||
TMPH-00171 |
PBP 4A Protein, Bacillus subtilis, Recombinant (His & SUMO)
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Bacillus subtilis | E. coli |
Probably involved in peptidoglycan modification during cortex synthesis. PBP 4A Protein, Bacillus subtilis, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 67.4 kDa and the accession number is P32959. | |||
TMPK-00693 |
HSP27/HSPB1 Protein, Human, Recombinant (His)
Hsp27,SRP27,HMN2B,HSP 27,HSPB1,CMT2F,HSP28 |
Human | E. coli |
Heat shock protein beta-1 (HSPB1, also known as HSP27) is a small heat shock protein involved in many cellular processes and reportedly protects cells against oxidative stress. This protein is expressed only in insulin-dependent tissues (heart, skeletal muscle, and fat tissue), and expression of HspB7 is regulated by many different factors. HspB7 has an unusual N-terminal sequence, a conservative α-crystallin domain, and very short C-terminal domain lacking conservative IPV tripeptide involved i... | |||
TMPK-00271 |
TPBG/5T4 Protein, Human, Recombinant (His & Avi)
M6P1,WAIF1,5T4,TPBG,5T4AG |
Human | HEK293 Cells |
The oncofetal tumor-associated antigen 5T4 (TBGP) has been linked with CSC properties in several different malignancies. 5T4 has functional attributes that are relevant to the spread of tumors including through EMT, CXCR4/CXCL12, Wnt, and Hippo pathways which may all contribute through the mobilization of CSCs. TPBG/5T4 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 38.2 kDa and the accession number is Q13641-1... | |||
TMPJ-00875 |
NPPB Protein, Human, Recombinant (His)
NPPB,γ-Brain Natriuretic Peptide,Gamma-Brain Natriu... |
Human | E. coli |
Human Natriuretic peptides B acts as a cardiac hormone; it is associated with many biological actions, such as diuresis, natriuresis, vasorelaxation, which inhibits the secretion of rennin and aldosterone. It acts as a paracrine antifibrotic factor in the heart. Natriuretic peptides B can help restore the body balance of salt and water, improves the heart function. Natriuretic peptides B binds and stimulates the cGMP production of the NPR1 receptor and binds the clearance receptor NPR3. | |||
TMPJ-01153 |
5T4/TPBG Protein, Cynomolgus, Recombinant (His)
TPBG,5T4,M6P1,WAIF1,5T4AG |
Cynomolgus | HEK293 Cells |
5T4/TPBG Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 55-80 KDa and the accession number is Q4R8Y9. | |||
TMPH-00994 |
EPB41L5 Protein, Human, Recombinant (His)
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Human | Baculovirus Insect Cells |
Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells. EPB41L5 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with N-10xHis tag. The predicted molecular weight is 84.3 kDa and the accession number is Q9HCM4. | |||
TMPH-02436 |
5T4/TPBG Protein, Cynomolgus, Recombinant (E. coli, His & Myc)
TPBG,Trophoblast glycoprotein,Wnt-activated inhibit... |
Cynomolgus | E. coli |
May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. 5T4/TPBG Protein, Cynomolgus, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 41.9 kDa and the accession number is Q4R8Y9. | |||
TMPJ-00268 |
5T4/TPBG Protein, Human, Recombinant (Avi & His), Biotinylated
5T4,M6P1,WAIF1,5T4AG,TPBG |
Human | HEK293 Cells |
5T4/TPBG Protein, Human, Recombinant (Avi & His), Biotinylated is expressed in HEK293 mammalian cells with C-Avi-6xHis tag. The predicted molecular weight is 60-90 KDa and the accession number is Q13641. | |||
TMPJ-01382 |
HSPB8 Protein, Human, Recombinant (His)
Small stress protein-like protein HSP22,CRYAC,E2IG1,Alpha-cr... |
Human | E. coli |
Heat shock protein beta-8 (HSPB8) belongs to the small heat shock protein (HSP20) family. This protein can be inducted by 17-beta-estradiol, and is predominantly expressed in skeletal muscle and heat, mainly located in the cytoplasm and nucleus. HSPB8 usually exists in monomer, it can interact with HSPB1 and DNAJB6. HSPB8 displays temperature-dependent chaperone activity,appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have bee... | |||
TMPH-03471 |
HupB Protein, Salmonella typhi, Recombinant (His & Myc & SUMO)
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Salmonella typhi | E. coli |
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. HupB Protein, Salmonella typhi, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 29.2 kDa and the accession number is P0A1R9. | |||
TMPH-00701 |
PBP1b Protein, E. coli, Recombinant (His & Myc)
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E. coli | E. coli |
Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits). PBP1b Protein, E. coli, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 38.6 kDa and the accession number is P02919... | |||
TMPH-03587 |
GspB Protein, S. gordonii, Recombinant (GST)
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Streptococcus gordonii | E. coli |
Plays a role in virulence and host-pathogen interactions. Mediates binding to human platelets via interaction with the human cell surface glycoprotein GP1BA. Plays a positive role in biofilm formation, possibly by self-association via the basic region (BR). GspB Protein, S. gordonii, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 68.5 kDa and the accession number is Q939N5. | |||
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