Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TPPB 是可渗透细胞的苯并内酰胺衍生蛋白的激酶 C 激活剂,Ki 值为11.9 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,660 | 现货 | ||
5 mg | ¥ 5,490 | 现货 | ||
10 mg | ¥ 8,160 | 现货 | ||
25 mg | ¥ 11,900 | 现货 | ||
50 mg | 特惠询价 | 待询 | ||
1 mL * 10 mM (in DMSO) | ¥ 6,690 | 现货 |
产品描述 | TPPB is a kinase C activator of cell-permeable benzolactam-derived protein (Ki: 11.9 nM). |
靶点活性 | PKC:11.9 nM (ki) |
体外活性 | TPPB inhibits the activation of caspase-3 induced by Aβ25-35. TPPB could increase the phosphorylation of Akt, PKC, MARCKS, and MAPK, which are inhibited by Aβ25-35 treatment. TPPB at a concentration of 1 μM could antagonize Aβ25-35 induced cell damage. By the use of a cell line derived from an Alzheimer’s disease patient, significant enhancement of sAPPα secretion is achieved at 1 μM concentration for TPPB. TPPB has a role against Aβ25-35-induced neurotoxicity in PC12 cells [1][2]. |
体内活性 | TPPB is evaluated for the induction of hyperplasia displays a modest response at 300 μg after topical application to the shaved backs of outbred Sencar mice and [1]. |
分子量 | 501.54 |
分子式 | C27H30F3N3O3 |
CAS No. | 497259-23-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (249.23 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.9939 mL | 9.9693 mL | 19.9386 mL | 49.8465 mL |
5 mM | 0.3988 mL | 1.9939 mL | 3.9877 mL | 9.9693 mL | |
10 mM | 0.1994 mL | 0.9969 mL | 1.9939 mL | 4.9846 mL | |
20 mM | 0.0997 mL | 0.4985 mL | 0.9969 mL | 2.4923 mL | |
50 mM | 0.0399 mL | 0.1994 mL | 0.3988 mL | 0.9969 mL | |
100 mM | 0.0199 mL | 0.0997 mL | 0.1994 mL | 0.4985 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
TPPB 497259-23-1 Chromatin/Epigenetic Cytoskeletal Signaling PKC Protein kinase C inhibit Inhibitor inhibitor