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T22231
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Adenosine Dialdehyde (ADOX)
腺苷二醛,Periodate-oxidized adenosine,Adenosine, periodate oxidized,Adenox,Adenosinedialdehyde
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Others |
Others |
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Adenosine Dialdehyde (Periodate-oxidized adenosine) 是嘌呤核苷类似物，是S-腺苷高半胱氨酸水解酶（SAHH）的有效抑制剂（Ki=3.3nM）。Adenosine Dialdehyde 在体内具有较强的抗肿瘤活性。 |
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T36173
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L-Glutathione, oxidized (sodium salt)
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Glutathione can occur in reduced (GSH), oxidized (GSSG), or in mixed disulfide forms and is ubiquitous in multiple biological systems serving as the major thiol-disulfide redox buffer of the cell. GSSG is the oxidized form of GSH . It can be reduced back to GSH through the NADPH-dependent enzyme glutathione reductase. GSSG functions as a hydrogen acceptor in the enzymatic determination of NADP+ and NADPH and can be a proximal donor in S-glutathionylation post translational modifications. The rat... |
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T78639
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Oxidized ATP trisodium salt
oATP trisodium salt
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P2X Receptor |
Membrane transporter/Ion channel;
Neuroscience |
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Oxidized ATP (oATP) trisodium salt 是一种P2 受体广泛抑制剂，其不可逆地阻断P2X7R活化并抑制CRP引发的NLRP3炎性体激活，常用于动脉粥样硬化研究。 |
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T8734
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Choline
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Others |
Others |
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Choline hydroxide 是一种普遍存在的水溶性营养素，通常与 B 族维生素有关。 |
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T20062
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Thiamine disulfide
二硫化硫胺,TDS,Daiomin,Algoneurina
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HIV Protease;
Endogenous Metabolite |
Metabolism;
Microbiology/Virology;
Proteases/Proteasome |
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Thiamine disulfide (Algoneurina) 是一种存在于食物中的维生素，可作为膳食补充剂和药物生产。 它还充当许多中枢代谢酶的辅助因子。 |
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T69111
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2',3'-Dialdehyde ATP
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2',3'-Dialdehyde ATP is a derivative of, and the oxidized form of, ATP. It has been found to be a specific, irreversible inhibitor of component A3 of the methylreductase system which plays a role in processing amino acids. |
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T2069L
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TH287 hydrochloride
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DNA/RNA Synthesis;
MTH1 |
Cell Cycle/Checkpoint;
DNA Damage/DNA Repair |
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TH287 hydrochloride 是一种选择性MTH1抑制剂，IC50值为 0.8 nM。它可用于治疗癌症的研究。 |
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T19294
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Docosahexaenoic Acid methyl ester
二十二六烯酸甲酯,Methyl docosahexaenoate,all cis-DHA methyl ester
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Others |
Others |
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Docosahexaenoic Acid methyl ester (all cis-DHA methyl ester) 是甲基化的二十二碳六烯酸类似物，能够插入膜磷脂中而不被氧化或水解。 |
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T7871
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Calcium D-saccharate tetrahydrate
D-Glucaric acid calcium salt,葡萄糖二酸鈣,Calcium D-saccharate tetrahydrate,D-Saccharic acid calcium salt
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Others |
Others |
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Calcium D-saccharate tetrahydrate (Calcium D-saccharate tetrahydrate) 是一种氧化的非环状己糖。它可以抑制癌细胞的癌变和增殖。 |
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T29099L
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VB 201
CI-201
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TLR |
Immunology/Inflammation |
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VB 201 是一种氧化磷脂小分子，具有抗炎活性，可抑制 CD14 和 Toll 样受体 2 依赖性先天细胞活化并限制动脉粥样硬化，可用于研究动脉粥样硬化。 |
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T83633
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1-N-Methyl-4-mercaptohistidine disulfide
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Others |
Others |
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1-N-Methyl-4-mercaptohistidine disulfide 是一种潜在的杜氏菌叶绿体偶联因子1氧化还原调节剂，是氧化形式的卵硫醇A，抑制光触发的CF1 ATP酶活性。 |
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T19210
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Biotin LC hydrazide
Biotinamidocaproyl hydrazide,Biotin Aminocaproyl Hydrazide,(+)-Biotinamidohexanoic Acid hydrazide,BACH
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Others |
Others |
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Biotin LC hydrazide (BACH) 是一种长链蛋白的修饰试剂。 生物素 LC 酰肼可转化高碘酸盐氧化的糖蛋白，可用于靶向糖蛋白和聚糖。 |
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T75342
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MitoSOX Red
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Reactive Oxygen Species;
Mitochondrial Metabolism;
Autophagy |
Autophagy;
Immunology/Inflammation;
Metabolism;
NF-κB |
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MitoSOX Red 是一种具有特异性和细胞膜渗透性且靶向活细胞线粒体的新型荧光探针。MitoSOX Red 进入线粒体后会被超氧化物氧化，而不会被其他 ROS 或 RNS 生成系统氧化。MitoSOX Red 随后与线粒体内核酸结合，产生强红色荧光。MitoSOX Red 可以作为荧光指示剂，特异性检测超氧化物。超氧化物歧化酶 (Superoxide dismutase，SOD) 能够预防 MitoSOX Red 氧化。 |
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T20094
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Adrenochrome
Adraxone
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Antioxidant |
oxidation-reduction |
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Adrenochrome (Adraxone) 是一种细胞毒性分子，可用于杀死细菌。Adrenochrome 是 Epinephrine 的氧化产物。Adrenochrome 是一种可作用于大鼠心脏的冠状动脉收缩化合物，与心脏毒性有关，可用于确定超氧化物歧化酶的活性。Adrenochrome 与可用于神经系统疾病研究，是拟精神病的潜在药物。 |
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T35941
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DC-Chol hydrochloride
Cholesteryl 3β-N-(dimethylaminoethyl)carbamate hydrochloride,DC-Chol (hydrochloride),DC-Cholesterol hydrochloride,Cholesteryl 3β-N-(dimethylaminoethyl)carbamate
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Beta Amyloid |
Neuroscience |
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DC-Chol hydrochloride(DC-Cholesterol hydrochloride) 在适当的实验条件下能抑制 Aβ40 纤维的形成且以剂量依赖性的方式显著抑制氧化hCT的淀粉样蛋白形成。DC-Chol hydrochloride可诱导改善和平衡的免疫力，能够促进乙型肝炎疫苗的研究。 |
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TP2488
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Palmitoyl Tripeptide-38 Acetate
Palmitoyl Tripeptide-38 Acetate(1447824-23-8 Free base),醋酸棕榈酰三肽 38
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Others |
Others |
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Palmitoyl Tripeptide-38 Acetate (Palmitoyl Tripeptide-38 Acetate (1447824-23-8 Free base)) 由三个氨基酸组成，是一种二氧化脂肽。该肽的灵感来自于胶原蛋白 VI 和层粘连蛋白中天然存在的三肽。它从内部重建需要的皮肤，抚平皱纹并舒缓皮肤，尤其是前额纹、鱼尾纹、前额纹和领口。 |
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T77577
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SLU-PP-332
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Estrogen/progestogen Receptor |
Endocrinology/Hormones |
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SLU-PP-332 是一种泛雌激素受体相关受体 (ERR) 激动剂，其对 ERRα, ERRβ 以及 ERRγ 具有很高的亲和力，EC50 值分别为 98、230 以及 430 nM。SLUPP-332 可增强骨骼肌细胞系的线粒体功能和细胞呼吸，增加 IIa 型氧化骨骼肌纤维并增强了运动耐力。SLU-PP-332 具有研究代谢性疾病以及肌肉功能改善的潜力，可能用于改善代谢紊乱和衰老。 |
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T37875
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Fenbendazole sulfone
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Fenbendazole sulfone is a minor metabolite of the anthelmintic fenbendazole . Fenbendazole undergoes oxidation to form oxfendazole, which is further oxidized to form fenbendazole sulfone. |
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T68217
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Diazoxon
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Diazoxon is the oxidized form of Diazinon -- an organophosphate insecticide. Diazoxon is shown to be a more potent acetylcholinesterase (AChE) inhibitor. |
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T35956
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PAz-PC
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Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic. Many of these substances were isolated and purified from oxLDL and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the sn-2 position. PAz-PC is one of the predominant oxLDL species and may be one of the important structural determinants of oxLDL. |
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T36002
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4-hydroxy Hexenal
4-HHE,4-hydroxy Hexenal
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4-hydroxy Hexenal is a lipid peroxidation product derived from oxidized ω-3 fatty acids such as DHA. [1][2] |
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T38312
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L-Cysteine-glutathione disulfide
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L-Cysteine-glutathione disulfide, a glutathione derivative endogenous to mammalian cells, is comprised of the oxidized form of free glutathione tripeptide linked via a disulfide bond to L-cysteine. It has been shown to protect mice against acetaminophen-induced hepatotoxicity. |
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T33490
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m-PEG12-aldehyde
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m-PEG12-aldehyde is a PEG derivative containing an aldehyde group. Aldehyde is reactive to hydrazide and aminooxy groups which are commonly used in biomolecular probes for labeling and crosslinking carbonyls (oxidized carbohydrates). The hydrophilic PEG s |
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T36066
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NADP+ (sodium salt hydrate)
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NADP+ is the oxidized form of the electron donor nicotinamide adenine dinucleotide phosphate . It serves as a cofactor in various biological reactions. In addition, the balance between these reduced and oxidized forms plays key roles in diverse cellular functions, including cell survival, the maintenance of redox status, and intracellular signaling. For example, binding of NADP+ to β-subunits of Kv channels activates ion transport, whereas NADPH stabilizes channel inactivation. NADP+ is biosynth... |
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T36727
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9(S)-HODE
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9(S)-HODE is produced by the lipoxygenation of linoleic acid in both plants and animals.[1],[2] It has been detected in atherosclerotic plaques, as an esterified component of membrane phospholipids and in oxidized LDL particles.[3] |
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T35580
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POV-PC
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Oxidized low-density lipoprotien (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic. Many of these substances were recently isolated and purified from oxLDL, and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the sn-2 position. 1-(Palmitoyl)-2-(5-oxovaleroyl)-phosphatidylcholine, or POV-PC, is one of the oxLDL species derived from 2-arachidonoyl or eicosapentanoyl phospholipids. POV-PC conf... |
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T36559
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(±)9-HODE
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(±)9-HODE is one of the two racemic monohydroxy fatty acids resulting from the non-enzymatic oxidation of linoleic acid. Approximately equal proportions of both isomers are found in mitochondrial and plasma membranes of rabbit reticulocytes. [1][2] Oxidized LDL contains significant amounts of esterified 9- and 13-HpODEs and HODEs. [3][4] |
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T35843
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9(R)-HODE cholesteryl ester
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9(R)-HODE cholesteryl ester was originally extracted from atherosclerotic lesions. It remains uncertain whether the oxidized fatty acid portion of the molecule results from enzymatic lipoxygenation or from random lipid peroxidation. 9(R)-HODE cholesteryl ester can be used as a standard for analysis of chiral HODE cholesteryl esters. |
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TNU0199
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8-Hydroxyadenosine
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Nucleoside Derivatives - 8-Modified purine nucleosides; Drugs and Inhibitors; Anticancer antibiotics; oxidized nucleic acid adduct; precursor of phosmidosine (P-prodrug) |
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T36172
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KOdiA-PC
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Oxidized low-density lipoprotien (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic. Many of these substances were recently isolated and purified from oxLDL, and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the sn-2 position. 1-(Palmitoyl)-2-(5-keto-6-octene-dioyl) phosphatidylcholine, or KOdiA-PC, is one of the most potent CD36 ligands among the oxLDL species. KOdiA-PC confers CD36 scave... |
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T37301
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PCTR2
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Protein conjugates in tissue regeneration 2 (PCTR2) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid . DHA is oxidized to 16S,17S-epoxy-protectin, which is converted to PCTR1 by glutathione S-transferase and to PCTR2 via γ-glutamyl transpeptidase. PCTR2 is found in resolving mouse exudate and in both M1 and M2 macrophages differentiated from isolated human monocytes. |
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T20014
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Patent Blue V calcium salt
Acid blue 3,L-Blau 3,Food Blue 3,Blue ZN 3,NSC 5010,C.I. 42051
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Acid blue is a dark bluish synthetic triphenylmethane dye. It used as a food coloring. The color of the dye is pH-dependent. The structure is also redox-sensitive, changing from a reduced yellow form to an oxidized red form in solution. It is usable as a |
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T35853
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9(S)-HODE cholesteryl ester
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9(S)-HODE cholesteryl ester was originally extracted from atherosclerotic lesions. It remains uncertain whether the oxidized fatty acid portion of the molecule results from enzymatic lipoxygenation or from random lipid peroxidation. 9(S)-HODE cholesteryl ester can be used as a standard for analysis of chiral HODE cholesteryl esters. |
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T19264
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D-Methionine sulfoxide hydrochloride
D-Methionine sulfoxide hydrochloride (21056-56-4 free base)
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Others |
Others |
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D-methionine sulfoxide hydrochloride is the D-isomer of methionine sulfoxide hydrochloride. Methionine sulfoxide is the oxidation product of methionine. Methionine is a restrictive amino acid in milk or legume proteins and is easily oxidized during storag |
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T36171
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KDdiA-PC
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Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic. Many of these substances were recently isolated and purified from oxLDL, and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the sn-2 position. KDdiA-PC is one of the most potent CD36 ligands among the oxLDL species. KDdiA-PC confers CD-36 scavenger receptor binding affinity to LDL at a frequency of only two... |
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T35976
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6-Formylpterin
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Xanthine oxidase (XO) generates reactive oxygen species, including hydrogen peroxide (H2O2), as it oxidizes specific substrates in the presence of water and oxygen. 6-Formylpterin is an oxidized pterin produced by photolytic breakdown of folic acid. It binds to one of two active sites on XO nearly quantitatively and irreversibly and prevents the metabolism of other substrates at the second site, resulting in hetero-substrate" inhibition at nanomolar concentrations. However |
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T35959
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PGPC
1-Palmitoyl-2-glutaryl phosphatidylcholine
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Others |
Others |
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PGPC (1-Palmitoyl-2-glutaryl phosphatidylcholine) 是一种氧化磷脂，以浓度依赖性方式激活过氧化物酶体增殖物激活受体。 |
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T83422
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1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine
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1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine 是一种由磷酸甘油、胆碱和棕榈酸构成的甘油磷酸胆碱类化合物，通常在体内氧化应激位点累积。该化合物是 B 类清道夫受体 (CD36和SR-BI) 的有效配体，特别是氧化磷脂 oxPC(CD36)。此外，氧化磷脂 (oxPLs) 在肿瘤细胞凋亡中扮演关键角色，并且在恶性胆管狭窄疾病中可能会有所增加。 |
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T35846
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13(R)-HODE cholesteryl ester
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13(R)-HODE cholesteryl ester was originally extracted from atherosclerotic lesions. It remains uncertain whether the oxidized fatty acid portion of the molecule results from enzymatic lipoxygenation or from random lipid peroxidation. 13(R)-HODE cholesteryl ester can be used as a standard for analysis of chiral HODE cholesteryl esters. |
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T36180
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Azelaoyl PAF
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Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which promote the differentiation of monocytes via the nuclear receptor PPARγ. One of these substances was recently isolated and purified from oxLDL, and identified as azelaoyl PAF. Azelaoyl PAF is a potent PPARγ agonist which competes for the thiazolidinedione binding site. Azelaoyl PAF is more potent than 15-deoxy-δ12,14-prostaglandin J2, and equipotent with rosiglitazone as a ligand for this receptor. |
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T36415
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N-Nitroso-N-methyl-4-Aminobutyric Acid
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N-Nitroso-N-methyl-4-aminobutyric acid (NMBA) is a tobacco-specific nitrosamine carcinogen.1It is oxidized to the reactive metabolite methyl-2-oxopropylnitrosamine (MOPN) in isolated rat liver mitochondria.2NMBA induces bladder transitional cell carcinomas in rats when administered in the drinking water at a concentration of 300 mg/L per day.3 |
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T35620
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Ethoxyquin Dimer
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Ethoxyquin dimer is an antioxidant and metabolite of ethoxyquin .1 It prevents oxidation of polyunsaturated fatty acids in fish meal and fish oil. Dietary administration of ethoxyquin dimer (0.1, 0.3, and 0.5% w/w) induces microvesicular steatosis and hepatocyte necrosis, as well as increases liver levels of oxidized glutathione and total lipids in mice.2 |
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T75537
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N-Acetyldopamine dimer-2
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N-Acetyldopamine dimer-2（compound 2）是一种从蝉皮黄色粉末中分离出来的N-acetyldopamine二聚体，具有抗氧化和抗炎作用。它能抑制氧化低密度脂蛋白（LDL）的氧化、ROS的生成、NO的生成以及NF-κB的活性。 |
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T37300
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PCTR1
PCTR1
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Protectin conjugates in tissue regeneration 1 (PCTR1) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid . DHA is oxidized to 16S,17S-epoxy-protectin, which is then converted to PCTR1 by glutathione S-transferase. PCTR1 levels increase during resolution of acute microbial-induced peritonitis in mice. PCTR1 (30 ng, i.p.) administration 12 hours post-infection increases macrophage numbers and activity and shortens the resolution phase of inflammation by 57%. It als... |
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T38123
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5(6)-Carboxy-2′,7′-dichlorofluorescein diacetate
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5(6)-Carboxy-2’,7’-dichlorofluorescein diacetate is an oxidant-sensitive and cell-permeable fluorescent probe.1Base hydrolysis of the ester bonds by intracellular esterases releases the acetate groups and the resulting compound, 5(6)-carboxy-2’,7’,-dichlorofluorescein, is oxidized by reactive oxygen species (ROS) and nitric oxide (NO) and displays excitation/emission maxima of 504 and 530 nm, respectively, which can be quantified as a measure of oxidant production.
1.Hempel, S.L., Buettner, G.R.... |
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T38099
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APF
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APF is an aromatic amino-fluorescein derivative and fluorescent probe for highly reactive radicals. It has low intrinsic fluorescence, however, upon oxidation by hydroxyl radical, hypochlorite ion, and certain peroxidase intermediates, it is converted to the highly fluorescent molecule fluorescein, facilitating the detection of highly reactive biological radicals. APF is not oxidized by nitric oxide (NO), hydrogen peroxide (H2O2), or other oxidants. Fluorescein displays excitation/emission maxim... |
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T36385
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Ansatrienin A
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Ansatrienin A is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis. In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 64 nM), which is a measure of bone resorption, and pp60c-srcM kinase (IC50 = 100 nM). It also inhibits TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1; IC50 = 570 nM). Early in vitro studies showed that ansatrienin A potentiates the chemotherapeutic action of 5-fl... |
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T74771
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Diaporthein B
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Diaporthein B 是氧化程度极高的 pimarane 二萜之一。Diaporthein B 表现出抗结核分枝杆菌的活性，MIC 为 3.1 μg/mL。Diaporthein B 显示对 HCT 116 和 LoVo 结肠癌细胞的 IC50为 1.5-3 μM/L。 |
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T76395
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(Met(O)35)-Amyloid β-Protein (1-42)
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'(Met(O)35)-Amyloid β-Protein (1-42)，Aβ42的一种氧化形态，位于Met35。该化合物可形成与Aβ40具有相似大小和分布特征的寡聚体，适用于阿尔茨海默病（AD）研究。' |
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T80056
|
Glutathione Peroxidase
GSH-Px,EC 1.11.1.9
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Glutathione Peroxidase |
Metabolism |
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Glutathione Peroxidase (GSH-Px; EC 1.11.1.9)，是一种关键的抗氧化酶，能催化GSH与过氧化氢或脂质过氧化物反应，生成GSSG和H2O，从而减缓氧化应激。此酶在生化研究中具有重要应用。 |
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