35
20
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T28072L |
MLN-3897 TFA
MLN-3897 TFA(1010731-97-1 Free base) |
CCR | Immunology/Inflammation; Microbiology/Virology |
MLN-3897 TFA 是一种有效的CCR1 拮抗剂,对 125I-MIP-1α 与 THP-1 细胞膜的结合具有抑制作用。 | |||
T16116 |
MLN-4760
|
RAAS | Endocrinology/Hormones |
MLN-4760 是选择性的人ACE2抑制剂,IC50=0.44 nM,对人ACE2的选择性是其他相关蛋白的 5000 多倍,包括人睾丸 ACE (IC50,>100 μM) 和牛 carboxypeptidase A (IC50,27 μM)。 | |||
T35187 |
XR 5944
XR-5944,MLN-944,MLN944,XR5944,MLN 944 |
||
XR 5944 is an effective DNA binder that stabilizes topoisomerase-dependent cleavage and has shown superior efficacy in a variety of mouse and human tumor models. | |||
T6315 |
MLN8054
|
Casein Kinase; PKA; Src; Aurora Kinase | Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Metabolism; Stem Cells; Tyrosine Kinase/Adaptors |
MLN8054是一种有口服活性的高选择性极光激酶抑制剂,IC50值为4 nM。 | |||
T2704 |
MLN0905
PLK1 Inhibitor |
PLK | Cell Cycle/Checkpoint |
MLN0905 (PLK1 Inhibitor) 是一种 PLK1的有效抑制剂,IC50值为 2 nM。 | |||
T77118 |
Plozalizumab
MLN-1202 |
CCR | Immunology/Inflammation; Microbiology/Virology |
Plozalizumab (MLN-1202) 是一种人源化具有选择性和有效性的抗 CCR2 抗体。Plozalizumab 具有抗肿瘤活性。Plozalizumab 可用于研究恶性黑色素瘤。 | |||
T71380 | MLN-0415 | ||
MLN-0415 is an IKK2 inhibitor which decreases NF-κB activation and down-regulates the expression of a number of inflammatory proteins. | |||
T6895 |
TAK-580
MLN2480,BIIB-024 |
Raf | MAPK |
TAK-580 (MLN2480) 是一种可口服的选择性Raf 广谱抑制剂。 | |||
T68427 |
MLN-3897 citrate
|
||
MLN-3897 citrate is a C-C Motif Chemokine Receptor 1 (CCR1) antagonist potentially for the treatment of multiple sclerosis and rheumatoid arthritis. | |||
T28072 |
MLN-3897
AVE9897,AVE 9897,CCR1 antagonist 10,AVE-9897 |
CCR | Immunology/Inflammation; Microbiology/Virology |
MLN-3897 (CCR1 antagonist 10) 是一种具有口服活性的 CCR1 拮抗剂,对于 125I-MIP-1α 与 THP-1 细胞膜的结合,Ki 为 2.3 nM。 MLN-3897 抑制 Akt 信号转导和 MM 细胞存活和增殖。 | |||
TQ0306 |
MLN120B
|
IκB/IKK | NF-κB |
MLN120B 是一种ATP 竞争性的、有效的、具有口服活性的IKKβ抑制剂,IC50=60 nM。它在体内外抑制多发性骨髓瘤细胞生长,也可用于研究类风湿关节炎。 | |||
T2241 |
Alisertib
MLN 8237,4-[[9-氯-7-(2-氟-6-甲氧基苯基)-5H-嘧啶并[5,4-D][2]苯并氮杂卓-2-基]氨基]-2-甲氧基苯甲酸 |
Apoptosis; Aurora Kinase; Autophagy | Apoptosis; Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic |
Alisertib (MLN 8237) 是一种口服活性和选择性的Aurora A 激酶抑制剂,IC50值为 1.2 nM。它通过靶向白血病细胞中的AKT/mTOR/AMPK/p38途径诱导其凋亡和自噬,具有抗肿瘤活性。 | |||
T6332 |
Pevonedistat
MLN4924 |
E1/E2/E3 Enzyme; NEDD8 | Metabolism; Ubiquitination |
Pevonedistat (MLN4924) 是一种 NEDD8 活化酶 (NAE) 抑制剂 (IC50=4.7 nM),具有有效性和选择性。Pevonedistat 可以用于骨髓增生异常综合症 (MDS)的治疗,也具有抗肿瘤活性。 | |||
T2122 |
Ixazomib
艾沙佐米,MLN2238 |
Proteasome; Caspase; Autophagy | Apoptosis; Autophagy; Proteases/Proteasome; Ubiquitination |
Ixazomib (MLN2238) 含硼肽蛋白酶体抑制剂(PI),可抑制 20S 蛋白酶体的糜蛋白酶样蛋白水解 (β5) 位点,IC50为 3.4 nM,Ki 为 0.93 nM。它还抑制半胱天冬酶样 (β1) 和胰蛋白酶样 (β2) 蛋白水解位点,IC50值为 31和3500 nM。 | |||
T2016 |
MLN9708
Ixazomib Citrate |
Proteasome | Proteases/Proteasome; Ubiquitination |
MLN9708 (Ixazomib Citrate) 抑制 20S 蛋白酶体的糜蛋白酶样蛋白水解 (β5) 位点 (Ki50=0.93 nM, IC50=3.4 nM/)。 MLN9708 的生物活性形式是水溶液或血浆中的 MLN2238。 | |||
T80554 |
Myoregulin
MLN peptide |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Myoregulin(MLN peptide)为调节蛋白家族成员,作用于肌肉性能调控,通过影响细胞内钙处理机制实现其功能。它直接与SERCA相互作用,抑制Ca2+进入肌浆网。 | |||
T80555 |
Myoregulin TFA
MLN peptide TFA |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Myoregulin (MLN peptide) TFA,作为调节蛋白家族成员,通过干预细胞内钙处理机制来调控肌肉功能。该化合物直接作用于肌浆网 Ca2+-ATPase (SERCA),抑制其将Ca2+传输至肌浆网。 | |||
T26339 |
XR-11576
MLN-576,MLN 576,MLN576,XR 11576 |
||
XR-11576 is a DNA topoisomerase I and II inhibitor for the treatment of solid tumors. | |||
T8397 |
Ixazomib citrate
枸橼酸艾沙佐米,MLN9708 |
Proteasome; Autophagy | Autophagy; Proteases/Proteasome; Ubiquitination |
Ixazomib citrate (MLN9708) 是 Ixazomib 的前药,是20S 蛋白酶体胰凝乳蛋白酶样蛋白水解β5位点的可逆抑制剂,IC50为3.4 nM 和Ki 为0.93 nM。 | |||
T72913 | (R)-MLN-4760 | ||
(R)-MLN-4760 是 MLN-4760 的活性较低的 R 型异构体,是一种ACE2抑制剂,IC50值为 8.4 μM。 | |||
T38428 |
Alisertib sodium
MLN 8237 sodium |
||
Alisertib sodium (MLN 8237) is a potent and specific inhibitor (IC50 = 1.2 nM) of Aurora A kinase, an enzyme involved in cell division. By binding to Aurora A kinase, Alisertib sodium disrupts the formation of the mitotic spindle and causes abnormal cell division. At the molecular level, it acts on the AKT/mTOR/AMPK/p38 pathway, leading to the induction of apoptosis and autophagy in leukemic cells. This compound exhibits significant antitumor activity. | |||
T3153 |
Serabelisib
TAK-117,INK1117,MLN1117 |
PI3K; mTOR | PI3K/Akt/mTOR signaling |
Serabelisib (INK1117) 是选择性的 p110α 抑制剂,其 IC50=15 nM。 | |||
T68489 |
MLN8054 sodium
|
||
MLN8054 sodium is an Aurora A inhibitor. | |||
T1838 |
Sapanisertib
沙帕色替,TAK-228,MLN0128,INK 128 |
PI3K; mTOR; Autophagy | Autophagy; PI3K/Akt/mTOR signaling |
Sapanisertib (INK 128) 是一种口服有效的 ATP 依赖性的mTOR1/2抑制剂,抑制 mTOR 激酶的IC50值为 1 nM,具有潜在抗肿瘤活性。 | |||
T16974 |
TAK-243
MLN7243 |
Apoptosis; E1/E2/E3 Enzyme; NF-κB | Apoptosis; NF-κB; Ubiquitination |
TAK-243 (MLN7243) 是一种泛素激活酶 UAE 的抑制剂 (IC50=1 nM),具有选择性。TAK-243 可阻断泛素结合,破坏单泛素信号传导以及整体蛋白质泛素化。TAK-243 具有抗肿瘤活性,可以促进细胞凋亡。 | |||
T1667 |
Tandutinib
MLN518,CT53518,NSC726292,坦度替尼 |
Apoptosis; FLT; CSF-1R; PDGFR; Src; c-Kit | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
Tandutinib (CT53518) 是一种选择性 FLT3抑制剂,其 IC50为 0.22 μM。它还抑制c-Kit 和PDGFR,其IC50分别为 0.17 μM 和 0.20 μM。它可穿透血脑屏障,用于急性骨髓性白血病。 | |||
T71378 | Exp9270 | ||
Exp9270 is an Angiotensin II receptor antagonist. | |||
T16117 |
Pevonedistat hydrochloride
MLN4924 hydrochloride |
Others | Others |
Pevonedistat hydrochloride is an effective and selective inhibitor of NEDD8-activating enzyme (IC50: 4.7 nM). | |||
T69982 |
VPC-16606
|
||
VPC-16606 is a potent and selective inhibitor of ERα-dependent cell growth and gene expression. VPC-16606 prevents the interaction between ERα-LBD and SRC-3 fusion proteins in a dose-dependent manner. | |||
T23418 |
Tandutinib (MLN518) HCl
|
Others | Others |
Tandutinib is an effective antagonist for FLT3, platelet-derived growth factor receptor (PDGFR), and c-Kit. Tandutinib potently inhibited the activity of FLT3, PDGFR, and c-Kit (IC50: ~200 nM). | |||
T69889 | JBP485 | ||
JBP485 is an inhibitor of renal transporters OAT1 and OAT3. JBP485 is an antihepatitis agent as a substrate for intestinal PEPT1. | |||
T62660 |
MLN3126
|
||
MLN3126 是一种口服具有活力的强效 CCR9 拮抗剂。 MLN3126 抑制 CCL25 诱导的钙动员 (calcium mobilization) 和小鼠初级胸腺细胞趋化 (chemotaxis) (IC50: 6.3 nM)。 | |||
T39199 |
ML 120B dihydrochloride
ML120B dihydrochloride |
||
MLN120B dihydrochloride (ML120B dihydrochloride) is a highly potent, orally active inhibitor of IKKβ. It competitively binds to ATP and exhibits an impressive IC50 value of 60 nM. This compound effectively suppresses the growth of multiple myeloma cells both in vitro and in vivo. Furthermore, MLN120B dihydrochloride is valuable in the field of rheumatoid arthritis research. | |||
T80556 |
wt hMLN
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
wt hMLN为抑制SR Ca2+泵(SERCA)的微量蛋白,对骨骼肌钙稳态具有关键作用。 | |||
T80770 |
wt hMLN TFA
|
||
wt hMLN (TFA) 是一种微量蛋白,能够抑制SR Ca2+泵 (SERCA);在骨骼肌的钙稳态调节中具有重要功能。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-04207 |
Motilin Protein, Human, Recombinant (His)
MLN,Motilin |
Human | HEK293 Cells |
MLN (Motilin) is a Protein Coding gene. 3 alternatively spliced human isoforms have been reported. This gene encodes a small peptide hormone that is secreted by cells of the small intestine to regulate gastrointestinal contractions and motility. The encoded protein belongs to the motilin family. Proteolytic processing of the secreted protein produces the mature peptide and a byproduct referred to as motilin-associated peptide (MAP). MLN plays an important role in the regulation of Interdigestive... | |||
TMPY-01137 |
HER2/ERBB2 Protein, Human, Recombinant (aa 1-652, His)
erb-b2 receptor tyrosine kinase 2,NEU,ENVW,HERV-7q,HERV7Q,HE... |
Human | HEK293 Cells |
HER2/ERBB2 Protein, Human, Recombinant (aa 1-652, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71 kDa and the accession number is P04626-1. | |||
TMPY-04684 |
HER2/ERBB2 Protein, Human, Recombinant (aa 1-195, His)
HERVWENV,MLN 19,HERV7Q,HERVW,CD340,NGL,erb-b2 recep... |
Human | HEK293 Cells |
HER2/ERBB2 Protein, Human, Recombinant (aa 1-195, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.9 kDa and the accession number is P04626-1. | |||
TMPY-00167 |
HER2/ERBB2 Protein, Human, Recombinant
HER-2/neu,erb-b2 receptor tyrosine kinase 2,HER2,HERV7Q,HERV... |
Human | HEK293 Cells |
HER2/ERBB2 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 70 kDa and the accession number is P04626-1. | |||
TMPY-05239 |
HER2/ERBB2 Protein, Human, Recombinant , Biotinylated
CD340,ENVW,ENV,HER2,HERV7Q,HERVWENV,HERV-7q,HER-2,TKR1,EGFR2... |
Human | HEK293 Cells |
HER2/ERBB2 Protein, Human, Recombinant , Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 70 kDa and the accession number is P04626-1. | |||
TMPY-04698 |
HER2/ERBB2 Protein, Human, Recombinant (aa 489-630, His)
HERV-7q,TKR1,HERV7Q,ENV,HER-2/neu,HERVWENV,NEU,ERVWE1,ENVW,H... |
Human | HEK293 Cells |
HER2/ERBB2 Protein, Human, Recombinant (aa 489-630, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.1 kDa and the accession number is P04626-1. | |||
TMPK-00429 |
HER2/ERBB2 Domain 4 Protein, Human, Recombinant (His & Avi)
HERV7Q,HER-2,HER2,NGL,EGFR2,ENVW,NEU,MLN 19,HERVW,C... |
Human | HEK293 Cells |
HER2/ERBB2 Domain 4 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 18.5 kDa and the accession number is P04626-1. | |||
TMPK-00430 |
HER2/ERBB2 Domain 4 Protein, Human, Recombinant (His & Avi), Biotinylated
MLN19,HERV7Q,HERVW,MLN 19,TKR1,herstatin,E... |
Human | HEK293 Cells |
HER2/ERBB2 Domain 4 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 18.5 kDa and the accession number is P04626-1. | |||
TMPK-00428 |
HER2/ErbB2 Protein, Human, Recombinant (His & Avi)
MLN 19,HER2,HER-2,HERVW,EGFR2,ENV,ERBB2,NEU,HERV7Q,... |
Human | HEK293 Cells |
ErbB2, also called Neu and Her2 (human epidermal growth factor receptor 2), is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for the epidermal growth factor (EGF) family of growth factors.Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. | |||
TMPY-04538 |
HER2/ERBB2 Protein, Human, Recombinant (aa 676-1255, His & GST)
TKR1,HERV-7q,ERVWE1,EGFR2,HERV7Q,HERVW,MLN19,HERVWE... |
Human | Baculovirus Insect Cells |
HER2/ERBB2 Protein, Human, Recombinant (aa 676-1255, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 92 kDa and the accession number is P04626-1. | |||
TMPY-00745 |
HER2/ERBB2 Protein, Human, Recombinant (hFc)
NEU,CD340,HER-2/neu,HERV7Q,TKR1,erb-b2 receptor tyrosine kin... |
Human | HEK293 Cells |
HER2/ERBB2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96.1 kDa and the accession number is P04626-1. | |||
TMPY-05368 |
HER2/ERBB2 Protein, Human, Recombinant (hFc), Biotinylated
HERVW,ERVWE1,MLN 19,HERV-W-ENV,HERVWENV,EGFR2,ENVW,... |
Human | HEK293 Cells |
HER2/ERBB2 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96.1 kDa and the accession number is P04626-1. | |||
TMPY-06612 |
HER2/ERBB2 Protein, Human, Recombinant (mFc)
HER2,MLN 19,erb-b2 receptor tyrosine kinase 2,HERVW... |
Human | HEK293 Cells |
HER2/ERBB2 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 95.75 kDa and the accession number is NP_004439.2. | |||
TMPY-05754 |
HER2/ERBB2 Protein, Human, Recombinant (aa 489-630, His), Amine-Labeled Biotinylated
MLN19,HERV-7q,MLN 19,HER-2,ERVWE1,EGFR2,er... |
Human | HEK293 Cells |
HER2/ERBB2 Protein, Human, Recombinant (aa 489-630, His), Amine-Labeled Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.1 kDa and the accession number is AAA75493.1. | |||
TMPY-05315 |
HER2/ERBB2 Protein, Human, Recombinant (His & Avi), Biotinylated
ERVWE1,HER-2/neu,NEU,HERV-7q,erb-b2 receptor tyrosine kinase... |
Human | HEK293 Cells |
HER2/ERBB2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 72.6 kDa and the accession number is P04626-1. | |||
TMPY-04955 |
HER2/ERBB2 Protein, Human, Recombinant (His), Amine-Labeled Biotinylated
HER2,MLN 19,HERVW,NEU,ERVWE1,EGFR2,HERV-7q,ENV,ENVW... |
Human | HEK293 Cells |
HER2/ERBB2 Protein, Human, Recombinant (His), Amine-Labeled Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71 kDa and the accession number is P04626-1. | |||
TMPJ-00778 |
HER2/ERBB2 Protein, Human, Recombinant (His)
TKR1,Metastatic lymph node gene 19 protein,ERBB2,Proto-oncog... |
Human | HEK293 Cells |
HER2/ERBB2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 90-120 KDa and the accession number is P04626. | |||
TMPY-01331 |
S100A11 Protein, Human, Recombinant
S100C,HEL-S-43,S100 calcium binding protein A11,MLN... |
Human | E. coli |
S100A11 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 24 and 12 kDa and the accession number is P31949. | |||
TMPJ-00777 |
HER2/ERBB2 Protein, Human, Recombinant (aa 23-652, hFc)
TKR1,Proto-oncogene Neu,EGFR2,Tyrosine kinase-type cell surf... |
Human | HEK293 Cells |
HER2/ERBB2 Protein, Human, Recombinant (aa 23-652, hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 120-145 KDa and the accession number is P04626. | |||
TMPJ-00776 |
HER2/ERBB2 Protein, Human, Recombinant (hFc & Avi), Biotinylated
Tyrosine kinase-type cell surface receptor HER2,NGL,EGFR2,TK... |
Human | HEK293 Cells |
HER2/ERBB2 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Fc-Avi tag. The predicted molecular weight is 120-140 KDa and the accession number is P04626. |