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Search Results for " f-3 "

Targets Recommended: Others

70

抑制剂 & 化合物

16

天然产物

85

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T15266	F16 (E)-4-(3-indolylvinyl)-N-methylpyridinium iodide	Others	Others
	F16 ((E)-4-(3-indolylvinyl)-N-methylpyridinium iodide)抑制neu-overeigning 细胞的生长和乳腺上皮的增殖。
T12961	Sofosbuvir impurity F 索非布韦杂质 F,Sofosbuvir 3',5'-Bis-(S)-phosphate	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Sofosbuvir impurity F (Sofosbuvir 3',5'-Bis-(S)-phosphate) 既是 Sofosbuvir 的非对映异构体，也是 Sofosbuvir 的杂质，Sofosbuvir 是 HCV RNA 复制的抑制剂。
T17877	VH032-cyclopropane-F VHL ligand 3,E3 ligase Ligand 19,Phenolic VH101	Others; Ligand for E3 Ligase	Others; PROTAC
	VH032-cyclopropane-F (Phenolic VH101) 是基于 VH032 的 VHL 配体。它能够利用 linker 与靶蛋白配体连接，得到 PROTAC 分子，如 PROTAC 1。PROTAC 1 是 SMARCA2 和 SMARCA4 的部分降解剂。
T39793	Fmoc-Tyr(3-F,tBu)-OH
	Fmoc-Tyr(3-F, tBu)-OH is a cyclic peptide compound possessing high membrane permeability and exhibiting specific binding affinity towards a target molecule.
T5821	BC-1215	Others; Ligand for E3 Ligase	Others; PROTAC
	BC-1215 是一种 F-box protein 3 抑制剂。它能够稳定 TRAF1-TRAF6 来抑制 Fbxo3-TRAF 激活途径。它与 ApaG 相互作用，阻碍来自人 PBMC 广谱 TH1 细胞因子的分泌。
T28769	SH-053-S-CH3-2'F
	SH-053-S-CH3-2'F is a potent and selective agonist of GABAA receptors.
T19840	GSK-F1 PI4KA inhibitor-F1	PI4K	PI3K/Akt/mTOR signaling
	GSK-F1 (PI4KA inhibitor-F1) 是一种新型强效 PI4KA 抑制剂。
T80851	VSTx-3 Kappa-TRTX-Gr4a,κ-Theraphotoxin-Gr4a,Voltage sensor toxin 3,Peptide F
	VSTx-3是KV通道阻断剂，同时也是TTX敏感钠通道尤其是NaV1.8通道的有效阻断剂。具体而言，其对hNaV1.3通道的IC50为0.19 μM，对hNaV1.7通道的IC50为0.43 μM，对hNaV1.8通道的IC50为0.77 μM。
T19688	Lodenosine FddA,3'-dideoxyarabinosyladenine,Fddl,2'-F-dd-ara-A,2'-Fluoro-2',DDG-1
	Lodenosine is an inhibitor of RNA-directed DNA polymerase, and potentially for the treatment of HIV.
TNU1377	3’-F-3’-dG(iBu)-2’-phosphoramidite
	3'-F-3'-dG(iBu)-2'-phosphoramidite is a Nucleoside Phosphoramidite.
TNU1246	3’-F-3’-dA(Bz)-2’-phosphoramidite
	3'-F-3'-dA(Bz)-2'-phosphoramidite is a Nucleoside Phosphoramidite; Nucleoside Derivative - Fluoro-modified nucleoside.
T126402	3-O-Methyltagitinin F
	3-O-Methyltagitinin F 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T126402。
T65479	Boc-Phe(3-F)-OH
	Boc-Phe(3-F)-OH 是一种氨基酸衍生物，在生命科学相关研究中具有广泛的应用。
T65692	Boc-D-Phe(3-F)-OH
	Boc-D-Phe(3-F)-OH 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65692，CAS号为 114873-11-9。
T65834	Fmoc-D-Phe(3-F)-OH
	Fmoc-D-Phe(3-F)-OH 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65834，CAS号为 198545-72-1。
T67306	H-D-Phe(3-F)-OH
	H-D-Phe(3-F)-OH 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T67306，CAS号为 110117-84-5。
T64556	Ir[p-F(t-Bu)-ppy]3
	Ir[p-F(t-Bu)-ppy]3 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64556。
T67591	5-Acetyl-3-chloro-10,11-dihydro-5H-dibenz[b,f]azepine
	5-Acetyl-3-chloro-10,11-dihydro-5H-dibenz[b,f]azepine 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T67591，CAS号为 25961-11-9。
T65901	3-Chloro-6,11-dihydro-6-methyl-5,5,11-trioxodibenzo[c,f][1,2]thiazepine
	3-Chloro-6,11-dihydro-6-methyl-5,5,11-trioxodibenzo[c,f][1,2]thiazepine 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65901，CAS号为 26638-53-9。
T66942	Ethyl 8-hydroxy-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate
	Ethyl 8-hydroxy-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66942，CAS号为 131666-45-0。
T23371	SMER3 SMER 3	Others; Ligand for E3 Ligase	Others; PROTAC
	SMER3 是选择性的 Skp1-Cullin-F-box (SCF)Met30泛素连接酶抑制剂。SMER 3 通过抑制 SCFMet30来增强 Rapamycin 的生长抑制作用。
T4603	PEO-IAA 2-(1H-Indol-3-yl)-4-oxo-4-phenyl-butyric acid	Others	Others
	PEO-IAA (2-(1H-Indol-3-yl)-4-oxo-4-phenyl-butyric acid) 是一种生长素拮抗剂，是一种吲哚-3-乙酸拮抗剂，能够与转运抑制剂响应蛋白 1/生长素信号 F-box 蛋白 (TIR1/AFBs) 结合。
T13401	Ziresovir AK0529,RO-0529	RSV	Microbiology/Virology
	Ziresovir (RO-0529) 是一种呼吸道合胞病毒融合蛋白 (RSV F) 抑制剂，抑制 RSV 活性，可用于研究合胞病毒感。
T31040	CP-18 F-18 CP18 F-18,CP 18 F-18,(18F)-CP18
	CP-18 F-18 is a DEVD (the caspase 3 substrate recognition motif) that is an imaging tracer for caspase-3 activity in apoptotic cells.
T73606	Bleomycin B4
	Bleomycin B4 (Phleomycin F)，一种具有抗肿瘤活性的抗生素，常用于癌症研究。
T125283	Ilicicolin F
	Ilicicolin F 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125283，CAS号为 22738-98-3。
T81053	T3SS-IN-3
	T3SS-IN-3为III型分泌系统（T3SS）抑制剂，能显著抑制hrpY基因转录，而不影响细菌生长。
T72451	SARS-CoV-2 Mpro-IN-6
	SARS-CoV-2 Mpro-IN-6为共价、不可逆及选择性抑制剂，主要针对SARS-CoV-2 Mpro，IC50值为0.18 μM。该化合物对人组织蛋白酶B、F、K、L以及半胱天冬酶3无抑制作用。
T67601	(4aR,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-Dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid
	(4aR,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-Dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T67601，CAS号为 103335-55-3。
T73964	Hydroxychloroquine Impurity F
	Hydroxychloroquine Impurity F为Hydroxychloroquine的一种杂质，后者为合成抗疟疾剂，能抑制Toll样受体7/9（TLR7/9）信号传导，并有效抑制SARS-CoV-2感染。
T74974	SQ-3
	SQ-3为一种喹啉类似物，对α-syn聚合体（Ki=39.3 nM）显示中等选择性，其选择性高于对β-淀粉样蛋白（Aβ）聚合体（Ki=230 nM）。[18F]SQ3展现出作为α-syn成像探针的先导化合物的基本属性。
T73301	ATR-IN-20
	ATR-IN-20是一种高效的ATR(ATM/ATR)抑制剂, IC50值仅为3 nM。该化合物还能抑制mTOR(IC50值为18 nM)，并展示出对PI3Kα(100 nM)、ATM(100 nM)和DNA-PK(662 nM)的良好选择性。ATR-IN-20具备优秀的药代动力学属性(F=30%)，同时显示了其抗癌潜力。
T35659	3'-Dephosphocoenzyme A
	3'-Dephosphocoenzyme A is an intermediate in the biosynthesis of coenzyme A from pantothenic acid .1 It is phosphorylated by CoA synthase in humans to form CoA. 3'-Dephosphocoenzyme A can be used as a transcription initiator in the synthesis of CoA-RNA by in vitro transcription.2,3 References1. Leonardi, R., Zhang, Y.M., Rock, C.O., et al. Coenzyme A: Back in action. Prog. Lipid Res. 44(2-3), 125-153 (2005).2. Huang, F. Efficient incorporation of CoA, NAD and FAD into RNA by in vitro transcripti...
T35485	6-Prenylindole
	6-Prenylindole is a bacterial metabolite that has been found in Streptomyces and has antifungal and antimalarial properties.1 It is active against A. brassicicola strain TP-F0423 and F. oxysporum f. sp. tulipae TU-4-2 (15 and 30 μg/disc in the paper disc assay), and also drug-resistant P. falciparum strain K1 (IC50 = 21 μg/ml).2 \|1. Sasaki, T., Igarashi, Y., Ogawa, M., et al. Identification of 6-prenylindole as an antifungal metabolite of Streptomyces sp. TP-A0595 and synthesis and bioactivity o...
T36737	3-hydroxy Myristic Acid methyl ester
	3-hydroxy Myristic acid methyl ester is a hydroxylated fatty acid methyl ester that has been found in E. camaldulensis and E. torelliana extracts. [1] It is active against M. tuberculosis (MIC = 49.5 μg/ml) and is non-cytotoxic to Vero cells (IC50 = >100 μM). 3-hydroxy Myristic acid methyl ester is also a volatile compound that contributes to the aroma of red wild strawberries (F. pentaphylla) but is not present in cultivated strawberries (Fragaria x ananassa).[2] Reference：[1]. Lawal, T.O., Ade...
T27595	Imarikiren HCl TAK-272 hydrochloride,TAK-272 HCl. Imarikiren HCl \|,TAK272,TAK 272,TAK-272
	Imarikiren is a potent, selective and orally active direct renin inhibitor. TAK-272 shows potent inhibitory activity against human renin (IC50 = 2.1 nM) in hPRA assay and excellent selectivity against other aspartic proteases, such as cathepsin D (IC50 >
T19689	Raluridine FddClUrd,935U-83,FCU,DRG-0215,BW-935U-83
	Raluridine is a RNA-directed DNA polymerase inhibitor potentially for the treatment of HIV infection. 935U83 inhibited virus growth with an average 50% inhibitory concentration (IC50: 1.8 microM) corresponding IC50s were 0.10 microM for FLT (3'-deoxy-3'-f
T36204	Methylatropine (nitrate)
	Methylatropine is an antagonist of muscarinic acetylcholine receptors (IC50= <0.1 nM in a radioligand binding assay using isolated porcine brain membranes) and a derivative of atropine .1,2It reduces acetylcholine-induced decreases in blood pressure in rats when administered intravenously with an ED50value of 5.5 μg/kg.2Methylatropine reduces salivation, induces mydriasis, and increases heart rate in dogs.3 1.Schmeller, T., Sporer, F., Sauerwein, M., et al.Binding of tropane alkaloids to nicotin...
T37105	2',3'-O-Isopropylideneguanosine
	2',3'-O-Isopropylideneguanosine is an alkylated guanosine building block.1,2It has been used in the synthesis of ordered honeycomb microporous films and mRNA cap analogs. 1.Gao, Y.-F., Huang, Y.-J., Xu, S.-Y., et al.Ordered honeycomb microporous films from self-assembly of alkylated guanosine derivativesLangmuir27(6)2958-2964(2011) 2.Kore, A.R., Shanmugasundaram, M., and Vlassov, A.V.Synthesis and application of a new 2',3'-isopropylidene guanosine substituted cap analogBioorg. Med. Chem. Lett.1...
T38353	Pyrenocine A
	Pyrenocine A is a fungal metabolite that has been found inP. terrestrisand has diverse biological activities.1It inhibits the asexual spore germination of the plant pathogenic fungiF. oxysporum,F. solani,M. hiemalis, andR. stolonifer(EC50s = 14, 20, 20, and 25 μg/ml, respectively). Pyrenocine A is active againstB. subtilis,S. aureus, andE. coli(IC50s = 30, 45, and 200 μg/ml, respectively). It inhibits onion seedling elongation (EC50= 4 μg/ml). Pyrenocine A is also a phytotoxin that inhibits lett...
T35452	β-Defensin-3 (human) (trifluoroacetate salt)
	β-Defensin-3 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. It inhibits the growth of the periodontopathogenic and cariogenic bacteria F. nucleatum, S. mutans, S. sobrinus, S. salivarius, and L. casei (MICs = 12.5-100 mg/l). It also inhibits the growth of S. aureus, S. pyogenes, P. aeruginosa, E. coli, and C. albicans. β-Defensin-3 stimulates gene expression and production of IL-6, IL-10, CXC...
T35515	3-Acetyldeoxy Nivalenol-13C17 3-Acetyldeoxy Nivalenol-13C17
	3-Acetyldeoxy nivalenol-13C17is intended for use as an internal standard for the quantification of 3-acetyldeoxy nivalenol by GC- or LC-MS. 3-Acetyldeoxy nivalenol is a mycotoxin that has been found inF. graminearum.1In vivo, 3-acetyldeoxy nivalenol (40 mg/kg) induces duodenal and splenic cell necrosis, as well as lethality (LD50= 70 mg/kg) in mice.2 1.Jiao, F., Kawakami, A., and Nakajima, T.Effects of different carbon sources on trichothecene production and Tri gene expression by Fusarium grami...
T36137	Biotin (S)-sulfoxide
	Biotin (S)-sulfoxide is an inactive metabolite of the coenzyme biotin .1,2It has also been found inE. coliand is reduced by the biotin sulfoxide reduction system as a source of biotin.3 1.Denkel, L.A., Rhen, M., and Bange, F.-C.Biotin sulfoxide reductase contributes to oxidative stress tolerance and virulence in Salmonella enterica serovar TyphimuriumMicrobiology (Reading)159(Pt 7)1447-1458(2013) 2.Carling, R.S., and Turner, C.Methods for assessment of biotin (Vitamin B7)Laboratory assessment of...
T38143	Elaidamide
	Elaidamide is a fatty acid amide that has been found in the cerebrospinal fluid of sleep-deprived cats.1 It inhibits rat microsomal epoxide hydrolase (mEH; Ki = 70 nM).2 Elaidamide also inhibits porcine pancreatic and human synovial phospholipase A2 (PLA2).3 In vivo, elaidamide (10 mg/animal) induces physiological sleep in rats.1References1. Cravatt, B.F., Prospero-Garcia, O., Siuzdak, G., et al. Chemical characterization of a family of brain lipids that induce sleep. Science 268(5216), 1506-150...
T35698	Octanoic Acid-13C
	Octanoic acid-13C is intended for use as an internal standard for the quantification of octanoic acid by GC- or LC-MS. Octanoic acid is a medium-chain saturated fatty acid. It has been found in Teleme cheeses made from goat, ovine, or bovine milk.1 Octanoic acid is active against the bacteria S. mutans, S. gordonii, F. nucleatum, and P. gingivalis (IC80s = <125, <125, 1,403, and 2,294 μM, respectively).2 Levels of octanoic acid are increased in the plasma of patients with medium-chain acyl-CoA d...
T37845	Taurocholic Acid 3-sulfate (sodium salt)
	Taurocholic acid 3-sulfate (TCA3S) is a metabolite of the conjugated bile acid taurocholic acid .1Plasma levels of TCA3S are elevated in wild-type andSortilin 1(Sort1) knockout mice at 6 hours following bile duct ligation (BDL) and are further elevated inSort1knockout mice at 24 hours post-BDL.2 1.Lefebvre, P., Cariou, B., Lien, F., et al.Role of bile acids and bile acid receptors in metabolic regulationPhysiol. Rev.89(1)147-191(2009) 2.Li, J., Woolbright, B.L., Zhao, W., et al.Sortilin 1 loss-o...
T37943	17-phenyl trinor Prostaglandin F2α isopropyl ester 17-phenyl trinor Prostaglandin F2α isopropyl ester
	17-phenyl trinor PGF2α N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name Bimatoprost. The N-ethyl amide prostaglandin prodrugs are converted to the active free acid more slowly than the analogous prostaglandin ester prodrugs such as latanoprost. This product is the isopropyl ester of the free acid prostaglandin which corresponds to Bimatoprost. The free acid, 17-phenyl trinor PGF2α, is a potent FP r...
T35893	rac-1,2-bis-Palmitoyl-3-chloropropanediol
	rac-1,2-bis-Palmitoyl-3-chloropropanediol is a 3-monochloropropane-1,2-diol (3-MCPD) ester.1It has been found as a contaminant in edible olive oils, with the lowest and highest concentrations in extra virgin and olive pomace oils, respectively.rac-1,2-bis-Palmitoyl-3-chloropropanediol has also been found in cottonseed and palm oils, as well as in shortening.2It induces renal tubular necrosis and a decrease in spermatids, but no gross pathological changes, in mice.3 1.Hung, W.-C., Peng, G.-J., Ts...
T36498	CAY10762 CAY10762
	CAY10762 is an inhibitor of monoacylglycerol lipase (MAGL; IC50= 34.1 nM).1It reduces hydrogen peroxide-induced lactate dehydrogenase (LDH) release from Neuro2a cells when used at a concentration of 1 μM. CAY10762 (10 mg/kg) increases levels of 2-arachidonoyl glycerol in mouse brain. 1.Castelli, R., Scalvini, L., Vacondio, F., et al.Benzisothiazolinone derivatives as potent allosteric monoacylglycerol lipase inhibitors that functionally mimic sulfenylation of regulatory cysteinesJ. Med. Chem.63(...
T38357	1,3,6,8-Pyrenetetrasulfonic Acid (sodium salt hydrate)
	1,3,6,8-Pyrenetetrasulfonic acid is an intermediate in the synthesis of the color additive pyranine.1It has been used to stabilize intermolecular interactions for the crystallization ofL. mexicanapyruvate kinase.2 1.Jitian, S., White, S.R., Yang, H.-H.W., et al.Conventional high-performance liquid chromatography versus derivative spectrophotometry for the determination of 1,3,6-pyrenetrisulfonic acid trisodium salt and 1,3,6,8-pyrenetetrasulfonic acid tetrasodium salt in the color additive D&C G...

化合物

Cat.No: T15266

Synonym: (E)-4-(3-indolylvinyl)-N-methylpyridinium iodide

Target: Others

Sofosbuvir impurity F

Cat.No: T12961

Synonym: 索非布韦杂质 F,Sofosbuvir 3',5'-Bis-(S)-phosphate

Target: HCV Protease

VH032-cyclopropane-F

Cat.No: T17877

Synonym: VHL ligand 3,E3 ligase Ligand 19,Phenolic VH101

Target: Others, Ligand for E3 Ligase

Fmoc-Tyr(3-F,tBu)-OH

Cat.No: T39793

Cat.No: T5821

Target: Others, Ligand for E3 Ligase

SH-053-S-CH3-2'F

Cat.No: T28769

Cat.No: T19840

Synonym: PI4KA inhibitor-F1

Target: PI4K

Cat.No: T80851

Synonym: Kappa-TRTX-Gr4a,κ-Theraphotoxin-Gr4a,Voltage sensor toxin 3,Peptide F

Cat.No: T19688

Synonym: FddA,3'-dideoxyarabinosyladenine,Fddl,2'-F-dd-ara-A,2'-Fluoro-2',DDG-1

3’-F-3’-dG(iBu)-2’-phosphoramidite

Cat.No: TNU1377

3’-F-3’-dA(Bz)-2’-phosphoramidite

Cat.No: TNU1246

3-O-Methyltagitinin F

Cat.No: T126402

Boc-Phe(3-F)-OH

Cat.No: T65479

Boc-D-Phe(3-F)-OH

Cat.No: T65692

Fmoc-D-Phe(3-F)-OH

Cat.No: T65834

H-D-Phe(3-F)-OH

Cat.No: T67306

Ir[p-F(t-Bu)-ppy]3

Cat.No: T64556

5-Acetyl-3-chloro-10,11-dihydro-5H-dibenz[b,f]azepine

Cat.No: T67591

3-Chloro-6,11-dihydro-6-methyl-5,5,11-trioxodibenzo[c,f][1,2]thiazepine

Cat.No: T65901

Ethyl 8-hydroxy-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate

Cat.No: T66942

Cat.No: T23371

Synonym: SMER 3

Target: Others, Ligand for E3 Ligase

Cat.No: T4603

Synonym: 2-(1H-Indol-3-yl)-4-oxo-4-phenyl-butyric acid

Target: Others

Cat.No: T13401

Synonym: AK0529,RO-0529

Target: RSV

Cat.No: T31040

Synonym: CP18 F-18,CP 18 F-18,(18F)-CP18

Cat.No: T73606

Cat.No: T125283

Cat.No: T81053

SARS-CoV-2 Mpro-IN-6

Cat.No: T72451

(4aR,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-Dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid

Cat.No: T67601

Hydroxychloroquine Impurity F

Cat.No: T73964

Cat.No: T74974

Cat.No: T73301

3'-Dephosphocoenzyme A

Cat.No: T35659

Cat.No: T35485

3-hydroxy Myristic Acid methyl ester

Cat.No: T36737

Cat.No: T27595

Synonym: TAK-272 hydrochloride,TAK-272 HCl. Imarikiren HCl |,TAK272,TAK 272,TAK-272

Cat.No: T19689

Synonym: FddClUrd,935U-83,FCU,DRG-0215,BW-935U-83

Methylatropine (nitrate)

Cat.No: T36204

2',3'-O-Isopropylideneguanosine

Cat.No: T37105

Cat.No: T38353

β-Defensin-3 (human) (trifluoroacetate salt)

Cat.No: T35452

3-Acetyldeoxy Nivalenol-13C17

Cat.No: T35515

Synonym: 3-Acetyldeoxy Nivalenol-13C17

Biotin (S)-sulfoxide

Cat.No: T36137

Cat.No: T38143

Octanoic Acid-13C

Cat.No: T35698

Taurocholic Acid 3-sulfate (sodium salt)

Cat.No: T37845

17-phenyl trinor Prostaglandin F2α isopropyl ester

Cat.No: T37943

Synonym: 17-phenyl trinor Prostaglandin F2α isopropyl ester

rac-1,2-bis-Palmitoyl-3-chloropropanediol

Cat.No: T35893

Cat.No: T36498

Synonym: CAY10762

1,3,6,8-Pyrenetetrasulfonic Acid (sodium salt hydrate)

Cat.No: T38357

Cat. No.	Product Name	Target	Signaling Pathways
T3829	Ginsenoside F3 人参皂苷F3	Others; IFNAR; Interleukin	Immunology/Inflammation; Others
	Ginsenoside F3 是一种皂苷，提取自Panax ginseng 叶片。它能够调节1 型 (IL-2, IFN-γ) 及 2 型细胞因子(IL-4 and IL-10) 的产生和表达，有免疫增强的作用。
T4S0498	Glaucocalyxin A 蓝萼甲素,Wangzaozin B,Leukamenin F	Apoptosis; Akt; Caspase; PI3K	Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Glaucocalyxin A (Leukamenin F) 是来自日本黑纹病菌的一种对映型月桂基二萜，具有抗肿瘤作用。它通过调节PI3K/Akt 信号通路抑制 GLI1 的核易位，诱导骨肉瘤凋亡。
T3826	Polygalasaponin F 异牡荆苷,瓜子金皂苷己	NF-κB; TLR; Akt; PI3K	Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR signaling
	Polygalasaponin F 是从瓜子金中提取的齐墩果烷型三萜皂苷，可通过调节TLR4-PI3K/AKT-NF-kB 信号通路减少神经炎症细胞因子的分泌，能降低炎性细胞因子肿瘤坏死因子 α 的释放。
T3208	Brevianamide F Cyclo-L-tryptophyl-L-proline,cyclo-(L-Trp-L-Pro),Cyclo(L-Pro-L-Trp)	BCRP; PI3K; Antibacterial	Membrane transporter/Ion channel; Microbiology/Virology; PI3K/Akt/mTOR signaling
	Brevianamide F (Cyclo(L-Pro-L-Trp)) 是一种从Colletotrichum gloeosporioides 中分离得到的真菌毒素，属于天然存在的 2,5-二酮哌嗪类，具有抗菌活性。它具有PI3Kα抑制活性，IC50值为 4.8 µM。
T12949	Sodium formononetin-3'-sulfonate Sul-F	Others	Others
	Sodium formononetin-3'-sulfonate is a water-sol. derivate of formononetin.
TN6448	3-Acetyl-ginsenoside F1
	3-Acetyl-ginsenoside F1 可用于生命科学领域的相关研究，其产品编号为 TN6448。
TN2119	Pulsatilla saponin H 白头翁属皂苷H,白头翁皂苷 H,3-O-Β-D-葡萄糖( 1→4)-[ A -L-鼠李糖(1→2)]- A-L-阿拉伯糖常春藤配基- 28-O-鼠李糖(1→4)葡萄糖(1→6)葡萄糖苷	Others	Others
	Pulsatilla saponin H 是一种从 Pulsatilla koreana 的根中分离出来的天然产物。
T36857	Estrone sulfate sodium 雌酮3-硫酸钠,Estrone 3-sulfate (sodium salt),17β-Estrone 3-sulfate	Endogenous Metabolite	Metabolism
	Estrone sulfate sodium (17β-Estrone 3-sulfate) 是一种主要的循环血浆雌激素，无生物活性，通过类固醇硫酸酯酶(STS) 转化为生物活性雌激素雌酮。
PDK0014	3-Methylxanthine	Endogenous Metabolite	Metabolism
	3-Methylxanthine 是一种黄嘌呤衍生物和环磷酸鸟苷（GMP）抑制剂，在豚鼠分离的气管肌肉中测得其IC50值为 920 μM。
TN5008	Shizukanolide F	Others	Others
	Shizukanolide F是一种天然产物，属于金粟兰科金粟兰属，其产品编号为 TN5008，CAS号为 120061-96-3。Shizukanolide F可用作对照参考。
TN5998	Elatoside F Tarasaponin VII,Caraganoside A
	Elatoside F 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5998，CAS号为 144118-18-3。
TN4411	Lappaol F	CDK; P-gp; JNK	Cell Cycle/Checkpoint; MAPK; Membrane transporter/Ion channel; Neuroscience
	1. Lappaol F has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. <br/> 2. Lappaol F has potential chemosensitizing activity, it may be candidates for developing novel adju
T75540	Ipomoeassin F
	Ipomoeassin F 是一种高效且具有选择性的内质网(ER)蛋白转位抑制剂，它通过作用于ER膜上的Sec61复合物（Sec61α）的成孔亚基来实现其功能。此化合物能特异性抑制SARS-CoV-2蛋白在ER膜上的转位，同时阻碍分泌蛋白和I型跨膜蛋白（TMP）的ER转运，但对III型TMP的转运不产生影响。
T37219	N-Palmitoyl Glycine
	The acyl amides are a family of endogenous lipids that act as potent modulators of pain and inflammation. The best characterized members of this family are the arachidonoyl amides, which includes N-arachidonoyl ethanolamide (AEA; anandamide). N-palmitoyl glycine (PalGly) contains an 18-carbon saturated fatty acid that is amide-linked to glycine and is structurally similar to the phospholipid-derived N-acyl ethanolamines. Endogenously produced in rat skin and spinal cord, PalGly is present in 100...
T36000	3-Hydroxyterphenyllin
	3-Hydroxyterphenyllin is a p-terphenyl fungal metabolite originally isolated from A. candidus that has diverse biological activities, including antioxidant, antiproliferative, antibacterial, and antiviral properties.1,2,3,4 It has a 96% scavenging effect on 2,2-diphenyl-1-picrylhydrazyl radicals when used at a concentration of 100 μg/ml.2 3-Hydroxyterphenyllin inhibits the growth of HeLa cervical, A549 lung, and HepG2 liver cancer cells (IC50s = 23, 36, and 32 μM, respectively), as well as methi...
T36954	Nemorosone
	Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.1 Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma cells (IC50s = 3.1-6.3 μM), including several drug-resistant clones, but not MRC-5 human embryonic fibroblasts (IC50 = >40 μM).2 It increases DNA fragmentation in LAN-1 cells in a dose-dependent manner, and decreases N-Myc protein levels and phosphorylation of ERK1/2 by MEK1/2. Nem...

天然产物

Cat.No: T3829

Synonym: 人参皂苷F3

Target: Others, IFNAR, Interleukin

Glaucocalyxin A

Cat.No: T4S0498

Synonym: 蓝萼甲素,Wangzaozin B,Leukamenin F

Target: Apoptosis, Akt, Caspase, PI3K

Polygalasaponin F

Cat.No: T3826

Synonym: 异牡荆苷,瓜子金皂苷己

Target: NF-κB, TLR, Akt, PI3K

Cat.No: T3208

Synonym: Cyclo-L-tryptophyl-L-proline,cyclo-(L-Trp-L-Pro),Cyclo(L-Pro-L-Trp)

Target: BCRP, PI3K, Antibacterial

Sodium formononetin-3'-sulfonate

Cat.No: T12949

Synonym: Sul-F

Target: Others

3-Acetyl-ginsenoside F1

Cat.No: TN6448

Pulsatilla saponin H

Cat.No: TN2119

Synonym: 白头翁属皂苷H,白头翁皂苷 H,3-O-Β-D-葡萄糖( 1→4)-[ A -L-鼠李糖(1→2)]- A-L-阿拉伯糖常春藤配基- 28-O-鼠李糖(1→4)葡萄糖(1→6)葡萄糖苷

Target: Others

Estrone sulfate sodium

Cat.No: T36857

Synonym: 雌酮3-硫酸钠,Estrone 3-sulfate (sodium salt),17β-Estrone 3-sulfate

Target: Endogenous Metabolite

3-Methylxanthine

Cat.No: PDK0014

Target: Endogenous Metabolite

Shizukanolide F

Cat.No: TN5008

Target: Others

Cat.No: TN5998

Synonym: Tarasaponin VII,Caraganoside A

Cat.No: TN4411

Target: CDK, P-gp, JNK

Cat.No: T75540

N-Palmitoyl Glycine

Cat.No: T37219

3-Hydroxyterphenyllin

Cat.No: T36000

Cat.No: T36954

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03295	Transferrin Protein, Mouse, Recombinant (His) transferrin,F3,Cf3	Mouse	HEK293
	Transferrin is a glycoprotein with an approximate molecular weight of 76.5 kDa. This glycoprotein is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of Transferrin is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as g...
TMPY-00720	Contactin 1 Protein, Human, Recombinant (His) contactin 1,F3,GP135,MYPCN	Human	HEK293
	Contactins are a subgroup of molecules belonging to the immunoglobulin superfamily that are expressed exclusively in the nervous system. The subgroup consists of six members: Contactin-1, Contactin-2 (TAG-1), Contactin-3 (BIG-1), BIG-2, Contactin-5 (NB-2) and NB-3. Since their identification in the late 1980s, Contactin-1 and Contactin-2 have been studied extensively. Axonal expression and the neurite extension activity of Contactin-1 and Contactin-2 attracted researchers to study the function o...
TMPY-03294	Transferrin Protein, Mouse, Recombinant (hFc) transferrin,Cf3,Cf-3...	Mouse	HEK293
	Transferrin is a glycoprotein with an approximate molecular weight of 76.5 kDa. This glycoprotein is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of Transferrin is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as g...
TMPY-00156	Cyclophilin F Protein, Human, Recombinant (His) peptidylprolyl isomerase F,CYP3,Cyp-D,CyP-...	Human	HEK293
	Cyclophilin F Protein, Human, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 20.3 kDa. Accession number: A0A024QZS4
TMPH-01309	EIF3F Protein, Human, Recombinant (His) eIF3 p47,eIF-3-epsilon,E...	Human	E. coli
	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly an...
TMPY-04320	CD300F/CD300LF Protein, Human, Recombinant (hFc) CLM1,NKIR,CD300 molecule-like family membe...	Human	HEK293
	CD300F/CD300LF Protein, Human, Recombinant (hFc) is expressed in HEK293 with hFc tag. The predicted molecular weight is 42.1 kDa. Accession number: Q8TDQ1-1
TMPY-05312	CD300F/CD300LF Protein, Human, Recombinant (His) CLM-1,IREM-1,CD300 molecule-like family me...	Human	HEK293
	CD300F/CD300LF Protein, Human, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 16.9 kDa. Accession number: Q8TDQ1-1
TMPK-00993	Coagulation Factor III/Tissue Factor Protein, Canine, Recombinant (His) Thromboplastin,CD142,TF,FLJ17960,TF	Canine	HEK293
	Tissue factor (also named Coagulation Factor III) is a cell surface glycoprotein responsible for initiating the extrinsic pathway of coagulation.Tissue factor is the primary cellular initiator of blood coagulation via interaction with coagulation factor VII. Aberrant expression of tissue factor is responsible for thrombosis during septic shock, atherosclerosis and cancer.
TMPY-05212	CD300F/CD300LF Protein, Mouse, Recombinant (mFc) RP23-342L24.3,CLIM1,IgSF...	Mouse	HEK293
	CD300F/CD300LF Protein, Mouse, Recombinant (mFc) is expressed in HEK293 with mFc tag. The predicted molecular weight is 45.3 kDa. Accession number: A0A1C9ZQ14
TMPY-06947	Asp f 3 Protein, Aspergillus Fumigatus, Recombinant	Aspergillus Fumigatus	E. coli
	Asp f 3 Protein, Aspergillus Fumigatus, Recombinant is expressed in E. coli. The predicted molecular weight is 19.41 kDa.
TMPH-03249	ATP5F1B Protein, Rat, Recombinant (His & Myc) ATPMB,ATPSB,ATP synthase subunit beta, mitochondrial,ATP syn...	Rat	E. coli
	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain ...
TMPH-02530	ATP5B Protein, Mouse, Recombinant (His & Myc & SUMO) ATP synthase F1 subunit beta,Atp5b,Atp5f1b...	Mouse	E. coli
	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain ...
TMPY-04935	CD47 Protein, Human, Recombinant (aa 1-139, His) MER6,CD47 molecule,IAP,OA3	Human	HEK293
	CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. It is very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the b...
TMPY-03763	Neuropilin-2 Protein, Human, Recombinant (hFc) Neuropilin-2,NPN2,neuropilin 2,PRO2714,VEGF165R2,NP...	Human	HEK293
	Neuropilin-2 (NRP-2) which is related to NRP-1, is a type I? transmembrane glycoprotein and has the structure characteristic with five main extracellular domains: two complement binding (CUB) domains, two coagulation factor V/VIII homology domains, and a MAM (meprin, tyrosine phosphatase domain) region. NRP-2 is a receptor capable of binding two disparate ligands, classⅢ semaphorins (SEMA) and vascular endothelial growth factors (VEGF), and thus regulates two diverse systems by activating cellul...
TMPY-00132	Mesothelin Protein, Human, Recombinant MPF,SMRP,Mesothelin	Human	HEK293
	The megakaryocyte potentiating factor belongs to the mesothelin family. This family is comprised of several mammalian pre-pro-megakaryocyte potentiating factor precursor (MPF) or mesothelin proteins. Mesothelin is a glycosylphosphatidylinositol-linked glycoprotein highly expressed in mesothelial cells, mesotheliomas, and ovarian cancer, but the biological function of the protein is not known. Megakaryocyte potentiating factor is highly expressed in mesotheliomas, ovarian cancers, and some squamo...
TMPY-06986	FGF-8b Protein, Human, Recombinant NEWENTRY,fibroblast growth factor 8 (andro...	Human	E. coli
	In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. Retinoic acid (RA) directly represses Fgf8 through a RARE-mediated mechanism that promotes repressive chromatin, thus providing valuable insight into the mechanism of RA-FGF antagonism during progenitor cell differentiation. Fgf8 encodes a key signaling fac...
TMPJ-01254	Siglec-F Protein, Mouse, Recombinant (His) sialic acid binding Ig like lectin 8,SAF2,SIGLEC-8,...	Mouse	Human Cells
	Siglec 5 to 11 share a high degree of sequence similarity with CD33/Siglec-3 both in their extracellular and intracellular regions. They are collectively referred to as CD33-related Siglecs. One remarkable feature of the CD33-related Siglecs is their differential expression pattern within the hematopoietic system. This fact, together with the presence of two conserved immunoreceptor tyrosine-based inhibition motifs (ITIMs) in their cytoplasmic tails, suggests that CD33-related Siglecs are involv...
TMPH-01226	CRMP1 Protein, Human, Recombinant ULIP3,Collapsin response mediator protein 1,CRMP1,D...	Human	E. coli
	Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance. During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone. Involved in invasive growth and cell migration. May participate in cytokinesis.
TMPY-01180	CD86 Protein, Human, Recombinant (His) CD86 antigen,B70,B7.2,B7-2,CD28LG2,LAB72	Human	HEK293
	CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominantly as a monomer on cell surfaces and interacts with two co-stimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus induces the signal pathways which regulate T cell activation and tolerance, cytokine production, and the generation of CTL. It is indicated that contacts between B ...
TMPY-05748	CD45 Protein, Human, Recombinant (aa 26-577, His) L-CA,T200,LCA,B220,protein tyrosine phosphatase, receptor ty...	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins d...
TMPY-04142	RANK/TNFRSF11A Protein, Human, Recombinant (hFc) OPTB7,OFE,OSTS,LOH18CR1,FEO,TRANCER,tumor ...	Human	HEK293
	TNFRSF11A is a member of the TNF-receptor superfamily. In mouse, it is also known as CD265. TNFRSF11A contains 4 TNFR-Cys repeats and is widely expressed with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. It is an essential mediator for osteoclast and lymph node development. TNFRSF11A and its ligand are important regulators of the interaction between T cells and dendritic cells. It can interact with various TRAF family proteins, through which this recep...
TMPJ-01099	IL-15RA Protein, Human, Recombinant (hFc, Human Cells) interleukin-15 receptor subunit α,IL15RA,interleukin-15 rece...	Human	Human Cells
	Interleukin 15 Receptor alpha (IL-15Rα) is a transmembrane glycoprotein that plays a pleiotropic role in immune development and function, including the positive maintenance of lymphocyte homeostasis. IL-15Rα chain can bind soluble IL-15 and “transpresent” cytokine to the cells, allowing them to respond to IL-15. Soluble IL-15Rα can function as a specific high-affinity IL-15 antagonist. The soluble IL-15/IL-15Rα complexes exhibit a strong agonistic activity which is mediated through membrane-boun...
TMPY-00892	Neuropilin-2 Protein, Human, Recombinant (His) NP2,PRO2714,VEGF165R2,neuropilin 2,NPN2,Neuropilin-...	Human	HEK293
	Neuropilin-2 (NRP-2) which is related to NRP-1, is a type I? transmembrane glycoprotein and has the structure characteristic with five main extracellular domains: two complement binding (CUB) domains, two coagulation factor V/VIII homology domains, and a MAM (meprin, tyrosine phosphatase domain) region. NRP-2 is a receptor capable of binding two disparate ligands, classⅢ semaphorins (SEMA) and vascular endothelial growth factors (VEGF), and thus regulates two diverse systems by activating cellul...
TMPY-01020	Periostin/OSF-2 Protein, Human, Recombinant (His) PN,OSF-2,OSF2,periostin,periostin, osteobl...	Human	HEK293
	Periostin ( POSTN ), also known as OSF2 (osteoblast specific factor 2), is a heterofunctional secreted extracellular matrix (ECM) protein comprised of four fasciclin domains that promotes cellular adhesion and movement, as well as collagen fibrillogenesis. Postn is expressed in unique growth centers during embryonic development where it facilitates epithelial-mesenchymal transition (EMT) of select cell populations undergoing reorganization. In the adult, Postn expression is specifically induced ...
TMPY-01897	PRSS3 Protein, Human, Recombinant (His) PRSS4,TRY4,TRY3,RP11-176F3.3<...	Human	HEK293
	Trypsin-3, also known as Trypsin III, brain trypsinogen, Serine protease 3 and PRSS3, is a secreted protein that belongs to the peptidase S1 family. Trypsin-3 / PRSS3 is expressed is in pancreas and brain. It contains one peptidase S1 domain. Trypsin-3 / PRSS3 can degrade intrapancreatic trypsin inhibitors that protect against CP. Genetic variants that cause higher mesotrypsin activity might increase the risk for chronic pancreatitis (CP). A sustained imbalance of pancreatic proteases and their ...
TMPY-05191	CD47 Protein, Human, Recombinant, Biotinylated CD47 molecule,MER6,OA3,IAP	Human	HEK293
	CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. It is very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the b...
TMPY-04683	CD47 Protein, Human, Recombinant MER6,CD47 molecule,OA3,IAP	Human	HEK293
	CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. It is very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the b...
TMPY-00072	GITR/TNFRSF18 Protein, Human, Recombinant (His) AITR,GITR-D,tumor necrosis factor receptor super	Human	HEK293
	GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases...
TMPH-01328	FBXL2 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degrada...
TMPY-04298	CDCP1 Protein, Human, Recombinant (His) TRASK,CD318,CUB domain containing protein 1,SIMA1	Human	HEK293
	CDCP1 contains three extracellular CUB domains. It is a putative stem cell marker that is highly expressed in some human cancer cells and both, typical and atypical (cancerous) colons. It interacts with CDH2/N-cadherin, CDH3/P-cadherin, SDC1/syndecan-1, SDC4/syndecan-4 and the serine protease ST14/MT-SP1. It also interacts with SRC and PRKCG/protein kinase C gamma. CDCP1 is taken as a key regulator of EGF/EGFR-induced cell migration. It has been shown that signaling via EGF/EGFR induces migratio...
TMPY-00480	NCAM1 Protein, Human, Recombinant (His) neural cell adhesion molecule 1,CD56,MSK39,NCAM	Human	HEK293
	NCAM1 (Neural Cell Adhesion Molecule 1, also known as CD56) is a Protein Coding gene. 3 alternatively spliced human isoforms have been reported. NCAM1 is a neural adhesion protein (NCAM) that belongs to the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. NCAM1 is involved in neuron-neuron adhesion, neurite fasciculation, the outgrowth of neurites, etc. It has also been shown to be...
TMPY-00357	HNT/NTM Protein, Human, Recombinant (His) HNT,NTRI,IGLON2,neurotrimin	Human	HEK293
	NTM (Neurotrimin) is a Protein Coding gene. 4 alternatively spliced human isoforms have been reported. This gene encodes a member of the IgLON (LAMP, OBCAM, Ntm) family of immunoglobulin (Ig) domain-containing glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules. IgLONs have been associated with psychiatric disorders, intelligence, body weight, heart disease, and tumors. The encoded protein may promote neurite outgrowth and adhesion via a homophilic mechanism. Neurotrimin is a mem...
TMPJ-00331	IFNAR1 Protein, Rhesus macaque, Recombinant (His) IFN-al,CRF2-1,IFN-alpha/beta rece...	Rhesus macaque	Human Cells
	Interferon‑alpha/beta receptor 1 (IFN‑ alpha / beta R1), also known as IFNAR1, are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. It interacts with STAT1 and STAT2, the interaction requires its phosphory...
TMPY-02243	IGSF3 Protein, Human, Recombinant (His) LCDD,immunoglobulin superfamily, member 3,...	Human	HEK293
	Immunoglobulin superfamily member 3 (IGSF3), also known as Glu-Trp-Ile EWI motif-containing protein 3, IgSF3 and EWI-3 and IGSF3, is a single-pass type I membrane protein that belongs to the EWI subfamily of the Ig superfamily of molecules. IGSF3 has an overall structural similarity and strong sequence similarity to V7, a human leukocyte surface protein. IGSF3 contains eight Ig-like C2-type (immunoglobulin-like) domains. IGSF3 is expressed in a wide range of tissues with high expression in the p...
TMPJ-00120	NKp80/KLRF1 Protein, Human, Recombinant (His) Lectin-like receptor F1,C-type lectin domain f<...	Human	Human Cells
	Killer cell lectin-like receptor subfamily F member 1 (KLRF1) is known as NKp80. Human NKp80, a member of the C-type lectin family of proteins (1 - 3), is 231 aa in length with a 38 amino acid (aa) cytoplasmic region, a 21 aa transmembrane region, and a 172 aa extracellular domain (ECD). The protein strongly expressed in peripheral blood leukocytes and spleen, with weaker expression in lymph node and adult liver, and no expression detected in bone marrow, thymus, and fetal liver. Its' function i...
TMPH-01671	Human metapneumovirus (strain CAN97-83) Fusion glycoprotein F0 (His & SUMO)	HMPV	E. coli
	Inactive precursor that is cleaved to give rise to the mature F1 and F2 fusion glycoproteins.; Class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and plasma cell membrane fusion, the coiled coil regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The forma...
TMPH-00341	Canine distemper virus (strain Onderstepoort) Fusion glycoprotein F0 (His & SUMO) F,Fusion glycoprotein F0	CDV	E. coli
	Class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and plasma cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and pl...
TMPH-02452	Measles virus (MeV) (strain Leningrad-16) Fusion glycoprotein F0 (Avi & His)	MeV	in vitro E. coli expression system
	Class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and plasma cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and pl...
TMPH-03764	YAP1 Protein, Human, Recombinant (His) YAP1-2gamma,YAP2L,YAP65	Human	Yeast
	Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1,...
TMPH-00698	OmpA Protein, E. coli, Recombinant (His)	E. coli	in vitro E. coli expression system
	With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm (Probable). Plays a role in resistance to environmental stress, and a role in outer membrane functionality and cell shape. Non-covalently binds peptidoglycan (Probable). Acts as a porin with low permeability that allows slow penetration of small solutes. A very abundant protein, there can be up to 210,000 OmpA molecules per cell. Reconstitution in unilamellar lipid vesicles shows only abou...
TMPH-01857	PIK3CG Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic response...
TMPH-03114	ITGB1 Protein, Pig, Recombinant (His & Myc)	Sus scrofa (Pig)	E. coli
	Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibr...
TMPH-03741	BoNT/F Protein, Clostridium botulinum, Recombinant (His) Bontoxilysin-F,BoNT/F,botF,Botuli...	Clostridium botulinum	E. coli
	Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release from the presynaptic membranes of nerve terminals of the eukaryotic host skeletal and autonomic nervous system, with frequent heart or respiratory failure. Precursor of botulinum neurotoxin F which may have 2 coreceptors; complex polysialylated gangliosides found on neural tissue and specific membrane-anchored proteins found in synaptic vesicles. Receptor proteins are exposed on host presynaptic cell ...
TMPY-03149	CDCP1 Protein, Human, Recombinant (mFc) TRASK,SIMA135,CD318,CUB domain containing ...	Human	HEK293
	CDCP1 contains three extracellular CUB domains. It is a putative stem cell marker that is highly expressed in some human cancer cells and both, typical and atypical (cancerous) colons. It interacts with CDH2/N-cadherin, CDH3/P-cadherin, SDC1/syndecan-1, SDC4/syndecan-4 and the serine protease ST14/MT-SP1. It also interacts with SRC and PRKCG/protein kinase C gamma. CDCP1 is taken as a key regulator of EGF/EGFR-induced cell migration. It has been shown that signaling via EGF/EGFR induces migratio...
TMPK-00447	CD45 Protein, Human, Recombinant (aa 26-577, hFc) CD45,CD45R,LCA,PTPRC,L-CA,T200,B220,GP180,LY5,EC 3....	Human	HEK293
	PTPRC (also known as CD45),T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) complex. CD45 ativates Lck by opposing the negative regulatory kinase Csk. Paradoxically, CD45 has also been implicated in suppressing TCR signaling by dephosphorylating the same signaling motifs within the TCR complex upon which Lck acts.
TMPY-03621	EphB2 Protein, Mouse, Recombinant (hFc) Tyro5,Erk,Qek5,ETECK,Hek5,Drt,EPH receptor B2,Nuk,Prkm5,Sek<...	Mouse	HEK293
	Ephrin type-B receptor 2, also known as EphB2, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. EphB2 receptor tyrosine kinase phosphorylates syndecan-2 and that this phosphorylation event is crucial for syndecan-2 clustering and spine formation. The Eph family of receptor tyrosine kinases (comp...
TMPY-01268	SMYD3 Protein, Human, Recombinant (GST) SET and MYND domain containing 3,ZMYND1,KMT3	Human	Baculovirus-Insect Cells
	SET and MYND domain-containing protein 3, also known as Zinc finger MYND domain-containing protein 1, SMYD3, and ZMYND, is a member of the histone-lysine methyltransferase family. SMYD3 contains one MYND-type zinc finger and one SET domain. SMYD3 is a histone H3 lysine-4-specific methyltransferase. It is expressed in skeletal muscles and testis. It is overexpressed in a majority of colorectal carcinoma (CRC) and hepatocellular carcinoma (HCC). SMYD3 plays an important role in transcriptional reg...
TMPY-04386	EphB2 Protein, Human, Recombinant (aa 570-987, His & GST) PCBC,CAPB,Hek5,EK5,EPHT3,EPH receptor B2,Tyro5,DRT,...	Human	Baculovirus-Insect Cells
	Ephrin type-B receptor 2, also known as EphB2, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. EphB2 receptor tyrosine kinase phosphorylates syndecan-2 and that this phosphorylation event is crucial for syndecan-2 clustering and spine formation. The Eph family of receptor tyrosine kinases (comp...
TMPJ-01288	KLF6 Protein, Human, Recombinant CPBP,GC-Rich Sites-Binding Factor GBF,Supp...	Human	E. coli
	Krueppel-Like Factor 6 (KLF6) belongs to the krueppel C2H2-type zinc-finger protein family. KLF6 contains three C2H2-type zinc fingers and localizes in the nucleus. KLF6 expression is highest in the placenta followed by spleen, thymus, prostate, testis, small intestinem and colon. However, it is weakly expressed in the pancreas, lung, liver, heart, and skeletal muscle. KLF6 functions as a transcriptional activator and could play a role in B-cell growth and development. Defects in KLF6 will resul...
TMPK-00400	FGFR2 beta (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated Fibroblast growth factor receptor 2,KG...	Human	HEK293
	Four distinct genes encoding closely related FGF receptors, FGF R1 - 4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid-box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain. Multiple forms of FGF R1 - 3 are generated by alternative splicing of the mRNAs. A frequent splicing event involving FGF R1 and 2 results in receptors...
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重组蛋白

Transferrin Protein, Mouse, Recombinant (His)

Cat.No: TMPY-03295

Species: Mouse

Expression System: HEK293

Contactin 1 Protein, Human, Recombinant (His)

Cat.No: TMPY-00720

Species: Human

Expression System: HEK293

Transferrin Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-03294

Species: Mouse

Expression System: HEK293

Cyclophilin F Protein, Human, Recombinant (His)

Cat.No: TMPY-00156

Species: Human

Expression System: HEK293

EIF3F Protein, Human, Recombinant (His)

Cat.No: TMPH-01309

Species: Human

Expression System: E. coli

CD300F/CD300LF Protein, Human, Recombinant (hFc)

Cat.No: TMPY-04320

Species: Human

Expression System: HEK293

CD300F/CD300LF Protein, Human, Recombinant (His)

Cat.No: TMPY-05312

Species: Human

Expression System: HEK293

Coagulation Factor III/Tissue Factor Protein, Canine, Recombinant (His)

Cat.No: TMPK-00993

Species: Canine

Expression System: HEK293

CD300F/CD300LF Protein, Mouse, Recombinant (mFc)

Cat.No: TMPY-05212

Species: Mouse

Expression System: HEK293

Asp f 3 Protein, Aspergillus Fumigatus, Recombinant

Cat.No: TMPY-06947

Species: Aspergillus Fumigatus

Expression System: E. coli

ATP5F1B Protein, Rat, Recombinant (His & Myc)

Cat.No: TMPH-03249

Species: Rat

Expression System: E. coli

ATP5B Protein, Mouse, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-02530

Species: Mouse

Expression System: E. coli

CD47 Protein, Human, Recombinant (aa 1-139, His)

Cat.No: TMPY-04935

Species: Human

Expression System: HEK293

Neuropilin-2 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-03763

Species: Human

Expression System: HEK293

Mesothelin Protein, Human, Recombinant

Cat.No: TMPY-00132

Species: Human

Expression System: HEK293

FGF-8b Protein, Human, Recombinant

Cat.No: TMPY-06986

Species: Human

Expression System: E. coli

Siglec-F Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01254

Species: Mouse

Expression System: Human Cells

CRMP1 Protein, Human, Recombinant

Cat.No: TMPH-01226

Species: Human

Expression System: E. coli

CD86 Protein, Human, Recombinant (His)

Cat.No: TMPY-01180

Species: Human

Expression System: HEK293

CD45 Protein, Human, Recombinant (aa 26-577, His)

Cat.No: TMPY-05748

Species: Human

Expression System: HEK293

RANK/TNFRSF11A Protein, Human, Recombinant (hFc)

Cat.No: TMPY-04142

Species: Human

Expression System: HEK293

IL-15RA Protein, Human, Recombinant (hFc, Human Cells)

Cat.No: TMPJ-01099

Species: Human

Expression System: Human Cells

Neuropilin-2 Protein, Human, Recombinant (His)

Cat.No: TMPY-00892

Species: Human

Expression System: HEK293

Periostin/OSF-2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01020

Species: Human

Expression System: HEK293

PRSS3 Protein, Human, Recombinant (His)

Cat.No: TMPY-01897

Species: Human

Expression System: HEK293

CD47 Protein, Human, Recombinant, Biotinylated

Cat.No: TMPY-05191

Species: Human

Expression System: HEK293

CD47 Protein, Human, Recombinant

Cat.No: TMPY-04683

Species: Human

Expression System: HEK293

GITR/TNFRSF18 Protein, Human, Recombinant (His)

Cat.No: TMPY-00072

Species: Human

Expression System: HEK293

FBXL2 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01328

Species: Human

Expression System: E. coli

CDCP1 Protein, Human, Recombinant (His)

Cat.No: TMPY-04298

Species: Human

Expression System: HEK293

NCAM1 Protein, Human, Recombinant (His)

Cat.No: TMPY-00480

Species: Human

Expression System: HEK293

HNT/NTM Protein, Human, Recombinant (His)

Cat.No: TMPY-00357

Species: Human

Expression System: HEK293

IFNAR1 Protein, Rhesus macaque, Recombinant (His)

Cat.No: TMPJ-00331

Species: Rhesus macaque

Expression System: Human Cells

IGSF3 Protein, Human, Recombinant (His)

Cat.No: TMPY-02243

Species: Human

Expression System: HEK293

NKp80/KLRF1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00120

Species: Human

Expression System: Human Cells

Human metapneumovirus (strain CAN97-83) Fusion glycoprotein F0 (His & SUMO)

Cat.No: TMPH-01671

Species: HMPV

Expression System: E. coli

Canine distemper virus (strain Onderstepoort) Fusion glycoprotein F0 (His & SUMO)

Cat.No: TMPH-00341

Species: CDV

Expression System: E. coli

Measles virus (MeV) (strain Leningrad-16) Fusion glycoprotein F0 (Avi & His)

Cat.No: TMPH-02452

Species: MeV

Expression System: in vitro E. coli expression system

YAP1 Protein, Human, Recombinant (His)

Cat.No: TMPH-03764

Species: Human

Expression System: Yeast

OmpA Protein, E. coli, Recombinant (His)

Cat.No: TMPH-00698

Species: E. coli

Expression System: in vitro E. coli expression system

PIK3CG Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01857

Species: Human

Expression System: E. coli

ITGB1 Protein, Pig, Recombinant (His & Myc)

Cat.No: TMPH-03114

Species: Sus scrofa (Pig)

Expression System: E. coli

BoNT/F Protein, Clostridium botulinum, Recombinant (His)

Cat.No: TMPH-03741

Species: Clostridium botulinum

Expression System: E. coli

CDCP1 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-03149

Species: Human

Expression System: HEK293

CD45 Protein, Human, Recombinant (aa 26-577, hFc)

Cat.No: TMPK-00447

Species: Human

Expression System: HEK293

EphB2 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-03621

Species: Mouse

Expression System: HEK293

SMYD3 Protein, Human, Recombinant (GST)

Cat.No: TMPY-01268

Species: Human

Expression System: Baculovirus-Insect Cells

EphB2 Protein, Human, Recombinant (aa 570-987, His & GST)

Cat.No: TMPY-04386

Species: Human

Expression System: Baculovirus-Insect Cells

KLF6 Protein, Human, Recombinant

Cat.No: TMPJ-01288

Species: Human

Expression System: E. coli

FGFR2 beta (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00400

Species: Human

Expression System: HEK293

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