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Search Results for " cdk5 "

75

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T37207L	Cdk5 Substrate acetate	CDK	Cell Cycle/Checkpoint
	Cdk5 Substrate acetate 是一种丝氨酸/苏氨酸激酶，主要在神经元组织中具有活性。与 p25 或 p35 一起，Cdk5 磷酸化一系列蛋白质，包括组蛋白 H1 和 tau。它是一种合成肽 (PKTPKKAKKL)，对应于组蛋白 H1 的序列。它被 Cdk5 磷酸化，Km 值为 5 µM。
T37207	Cdk5 Substrate Cdk5 Substrate
	Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase that is predominantly active in neuronal tissues. With p25 or p35, Cdk5 phosphorylates a range of proteins, including histone H1 and tau. Cdk5 substrate is a synthetic peptide (PKTPKKAKKL) corresponding to a sequence of histone H1. It is phosphorylated by Cdk5 with a Km value of 5 μM.
T36742	CDK5 inhibitor 20-223 CDK5 inhibitor 20-223
	CDK5 inhibitor 20-223, a potent inhibitor of CDK2 and CDK5, demonstrates IC50 values of 6.0 nM and 8.8 nM, respectively. It serves as an effective agent against colorectal cancer (CRC)[1].
T40263	CDK5-IN-1 CDK5-IN-1
	CDK5-IN-1 is a highly potent inhibitor of CDK5, displaying an inhibitory activity of less than 10 nM. This potent compound is specifically employed in scientific investigations relating to kidney diseases.
T35555	GSK-3/CDK5/CDK2-IN-1 GSK-3/CDK5/CDK2-IN-1
	GSK-3/CDK5/CDK2-IN-1 is an imidazole derivative compound that inhibits cdk5, cdk2, and GSK-3.it has demonstrated applications in cancer research and the study of neurodegenerative diseases [1].
TP1602	[pThr3]-CDK5 Substrate
	[pThr3]-CDK5 Substrate is an effective Phospho-Thr3CDK5 Substrate.[pThr3]-CDK5 Substrate is phosphorylated by CDK5 with a Km value of 6 µM[1].
TP1660	[pThr3]-CDK5 Substrate (TFA)
	[pThr3]-CDK5 Substrate TFA is an effective Phospho-Thr3CDK5 Substrate. [pThr3]-CDK5 Substrate is phosphorylated by CDK5 with a Km value of 6 µM.
T63184	CDK5-IN-2
	CDK5-IN-2 (compound 15) 是一种高选择性的 CDK5 抑制剂，能够作用于 CDK5/p25 (IC50: 0.2 nM) 和 CDK2/CycA (IC50: 23 nM)。
T76031	[pThr3]-CDK5 Substrate TFA
	[pThr3]-CDK5 Substrate TFA 是 Thr3 磷酸化的CDK5底物。[pThr3]-CDK5 Substrate 来自组蛋白 H1，位于组蛋白 H1 上和CDK5作用的位点。CDK5Substrate 被CDK5磷酸化为 [pThr3]-CDK5 Substrate 的 Km 为 6 μM。
T61362	CDK5-IN-3
	CDK5-IN-3 (compound 11) is a highly potent and selective inhibitor of CDK5, demonstrating significant inhibition with IC50 values of 0.6 nM and 18 nM for CDK5/p25 and CDK2/CycA, respectively. This compound holds promise for further investigation in the context of autosomal dominant polycystic kidney disease (ADPKD) research [1].
T7426	ALSTERPAULLONE	Apoptosis; GSK-3; CDK	Apoptosis; Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells
	Alsterpaullone 是高效的 CDK 抑制剂，是一种 ATP 竞争性的 GSK-3alpha/GSK-3beta 抑制剂，且作用的 IC50值都为 4 nM。它有用于神经退行性和增生性疾病的研究潜力，具有抗肿瘤活性，诱导白血病细胞凋亡。
T7167	Purvalanol B NG 95,(2R)-2-[[6-[(3-氯-4-羧基苯基)氨基]-9-(1-甲基乙基)-9H-嘌呤-2-基]氨基]-3-甲基-1-丁醇	CDK; Parasite	Cell Cycle/Checkpoint; Microbiology/Virology
	Purvalanol B (NG 95) 是选择性可逆的 ATP 竞争性 CDK 抑制剂。它在一系列其他蛋白激酶 (IC50>1000 nM) 中显示出对 CDK 的选择性。它抑制耐氯喹菌株 P. falciparum 的生长。
T8230	PNU112455A hydrochloride PNU 112455A	CDK	Cell Cycle/Checkpoint
	PNU112455A hydrochloride 是 CDK2 和 CDK5 的 ATP 位点竞争性抑制剂，与 CDK2 和 CDK5 的 ATP 位点结合，Km 值为 3.6 和 3.2 μM。
T2440	IC261 SU-5607	Apoptosis; Casein Kinase; CDK	Apoptosis; Cell Cycle/Checkpoint; Metabolism; Stem Cells
	IC261 (SU-5607) 是一种选择性的，ATP 竞争性的CK1抑制剂，可触发有丝分裂检查点控制。对Ckiδ、Ckiε、 Ckiα1 和Cdk5的IC50值分别为 1 μM、1 μM 、16 μM 和4.5mM。
TQ0068	NVP-LCQ195 AT9311,LCQ-195	CDK	Cell Cycle/Checkpoint
	NVP-LCQ195 (LCQ-195) 是CDK 杂环类抑制剂，对CDK1，CDK2，CDK3和CDK5的IC50为1到42 nM 之间。
T2095	Seliciclib Roscovitine,R-roscovitine,CYC202	CDK	Cell Cycle/Checkpoint
	Seliciclib (Roscovitine) 是 Cdk2/cyclin E 的有效抑制剂，IC50为0.1 µM。它还抑制 Cdk7/cyclin H、Cdk5/p35 和 Cdc2/cyclin B，IC50为 0.49、0.16和0.65 µM。
T77341	GSK-3 inhibitor 4	GSK-3; CDK	Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells
	GSK-3 inhibitor 4 是一种具有口服活性和脑渗透性的 GSK-3，CDK2 和 CDK5 三重抑制剂，对 GSK-3β，GSK-3α，CDK2 和 CDK5 具有抑制作用，IC50 值分别为 0.56 nM ，0.45 nM ，0.47 μM，0.68 μM。GSK-3 inhibitor 4 可有效降低 Tau protein 水平。GSK-3 inhibitor 4 可用于研究阿尔茨海默症。
T2247	KenPaullone 9-Bromopaullone,NSC-664704,9-溴-7,12-二氢吲哚并[3,2-D][1]苯并氮杂卓-6(5H)-酮	GSK-3; CDK	Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells
	KenPaullone (9-Bromopaullone) 是一种CDK1/cyclin B 和GSK-3β抑制剂，IC50值分别为 0.4 μM 和 23 nM。它也抑制 CDK2/cyclin A、CDK2/cyclin E 和 CDK5/p25 的活性，IC50值分别为 0.68 μM、7.5 μM 和 0.85 μM。。它通过增强 TGFβ-Smad3 信号通路增加和延长 foxp3 基因的转录来促进 iTreg 细胞分化。
T1917	GSK 3 Inhibitor IX BIO,GSK 3 IX,6-BIO,6-Bromoindirubin-3'-oxime,MLS 2052,6-bromoindirubin-3-oxime	Apoptosis; GSK-3; Tyrosine Kinases; CDK	Apoptosis; Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
	GSK 3 Inhibitor IX (6-BIO) 是一种选择性可逆的，ATP 竞争性的 GSK-3α/β和 CDK1-cyclinB 复合体抑制剂，能够抑制 (GSK-3α/β)/CDK1/CDK5 的活性，IC50值分别为 5 nM/320 nM/83 nM。
T1912	Dinaciclib SCH 727965,PS-095760	Apoptosis; CDK	Apoptosis; Cell Cycle/Checkpoint
	Dinaciclib (SCH 727965) 是一种 CDK 抑制剂，抑制 CDK1、CDK2、CDK5 和 CDK9 (IC50分=3/1/1/4 nM)，具有选择性。Dinaciclib 具有潜在的抗肿瘤活性，可以抑制胸甘 (dThd) DNA 的整合。
T5200	Indirubin-3'-monoxime 靛玉红-3' -单肟,Indirubin-3'-oxime	GSK-3; Lipoxygenase; CDK	Cell Cycle/Checkpoint; Metabolism; PI3K/Akt/mTOR signaling; Stem Cells
	Indirubin-3'-monoxime (Indirubin-3'-oxime) 是一种有效的 GSK3β 抑制剂，IC50值为 22 nM。它对 CDK5/p25、CDK1/cyclin B 和CDk2/cyclin E 也有作用，IC50值分别为 100、180 和 250 nM。
T6358	1-Azakenpaullone 1-氮杂坎帕罗酮,azakenpaullone	GSK-3	PI3K/Akt/mTOR signaling; Stem Cells
	1-Azakenpaullone (azakenpaullone) 是一种 ATP 竞争性的、具有高度选择性的糖原合成酶激酶3 β (GSK-3β)的抑制剂，其 IC50=18 nM。
T21588	Olomoucine	ERK; CDK	Cell Cycle/Checkpoint; MAPK
	Olomoucine 是 Cdk2/cyclin A、Cdc2/CyclinB、CDK2/CyclinE、CDK5/p35 和 ERK1/p44 MAP 激酶的 ATP 竞争性抑制剂，IC50 分别为 7、7、7、3 和 25 µM。 Olomoucine 调节细胞周期并表现出抗黑色素肿瘤活性。
T36964	BML-259 CAY10554	CDK	Cell Cycle/Checkpoint
	BML-259 是 CDK5 和 CDK2 的抑制剂，IC50 分别为 64 和 98 nM。 BML-259 可用于癌症和神经退行性疾病治疗的研究。
T23389	SR1664 SR 1664	PPAR	DNA Damage/DNA Repair; Metabolism
	SR1664 是一种PPARγ拮抗剂，与结合PPARγ，可有效抑制 Cdk5 介导的PPARγ磷酸化，IC50为80 nM，Ki 为 28.67 nM。
T21720	GP-82996 Cdk4/6 Inhibitor IV,CINK4	CDK	Cell Cycle/Checkpoint
	GP-82996 (CINK4) (CINK4) 是 CDK4/6的药理学抑制剂。GP-82996 对 CDK4/cyclin D1、CDK6/cyclin D1 和 Cdk5/p35 的 IC50s 分别为 1.5、5.6 和 25 μM。GP-82996 诱导肿瘤细胞 U2OS 的凋亡，可用于癌症研究。
T6787	BIO-acetoxime BIA,GSK-3 Inhibitor X	Apoptosis; GSK-3; HSV	Apoptosis; Microbiology/Virology; PI3K/Akt/mTOR signaling; Stem Cells
	BIO-acetoxime (GSK-3 Inhibitor X) 是一种 GSK3α/β 抑制剂，IC50值均为 10 nM，具有抗惊厥和抗感染作用。
T2378	RGB-286638 free base	GSK-3; MEK; JAK; CDK	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; JAK/STAT signaling; MAPK; PI3K/Akt/mTOR signaling; Stem Cells
	RGB-286638 free base 是一种新型 CDK 抑制剂，抑制cyclin T1-CDK9、cyclin B1-CDK1、cyclin E-CDK2、cyclin D1-CDK4、cyclin E-CDK3和p35-CDK5活性，IC50分别为 1、2、3、4、5 和 5 nM。它也抑制 GSK-3β、TAK1、Jak2 和 MEK1，IC50值分别为 3、5、50和 54 nM。
T61439	DSS30	Beta Amyloid; BACE; CDK	Cell Cycle/Checkpoint; Neuroscience
	DSS30 是一种 P25/CDK5抑制剂。DSS30通过抑制淀粉样前体蛋白裂解酶1 (BACEl) 磷酸化，减少 β-淀粉样蛋白 (Aβ) 的分泌发挥作用。DSS30 可用于预防和治疗阿尔茨海默病等神经退行性疾病。
T22260	Aminopurvalanol A	CDK	Cell Cycle/Checkpoint
	Aminopurvalanol A 是一种竞争性、选择性和细胞渗透性的Cyclins/Cdk 复合物抑制剂，优先靶向G2/M 期转变进而抑制癌细胞分化。它通过抑制生理获能依赖性肌动蛋白聚合而抑制精子受精能力。
T6940	PHA-767491 hydrochloride CAY10572,PHA-767491,PHA767491 HCl,CAY-10572 hydrochloride	Apoptosis; GSK-3; CDK	Apoptosis; Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells
	PHA-767491 hydrochloride (CAY-10572 hydrochloride) 是一种Cdc7-Dbf4(DDK)/Cdk9的双重抑制剂，IC50值分别为 10 nM 和 34 nM。
T10898	Samuraciclib hydrochloride ICEC0942 hydrochloride,CT7001 hydrochloride	Apoptosis; CDK	Apoptosis; Cell Cycle/Checkpoint
	Samuraciclib hydrochloride (ICEC0942 hydrochloride) 是一种具有选择性，ATP 竞争性和口服活性的CDK7抑制剂，IC50为 41 nM。它以 GI50值为 0.2-0.3 µM 来抑制乳腺癌细胞系的生长，具有抗肿瘤作用。
T2506	AZD-5438 AZD5438	CDK	Cell Cycle/Checkpoint
	AZD-5438 有效抑制 CDK1,CDK2,CDK9，IC50值分别为 16 nM, 6 nM, 20 nM，但它对 GSK3β，CDK5，CDK6 的抑制作用较弱。
T2059	Purvalanol A NG-60	Apoptosis; CDK; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint
	Purvalanol A (NG-60) 是一种CDK 抑制剂，对 cdc2-cyclin B、cdc2-cyclin B、cdk2-cyclin E、cdk4-cyclin D1 和 cdk5-p35 的IC50值分别为 4、70、35、850 和 75 nM。
T14943	CGP60474	VEGFR; CDK; PKC	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	CGP60474 是一种高效的抗内毒素药物，抑制细胞周期蛋白依赖激酶(CDK) ，抑制 CDK1/B、CDK2/E、CDK2/a、CDK4/D、CDK5/p25、CDK7/H 和 CDK9/T 的IC50分别为 26、3、4、216、10、200 和 13 nM。它是选择性和 ATP 竞争性PKC 抑制剂。
T10172	5-Iodo-indirubin-3'-monoxime	GSK-3; CDK	Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells
	5-Iodo-indirubin-3'-monoxime 是一种 GSK-3β、CDK5/P25和CDK1/cyclin B 抑制剂，IC50值分别为 9、20 和 25 nM，与 ATP 竞争性地结合酶的催化位点。
T71486	NS-0011
	NS-0011 is an inhibitor of CDK5 translocation which increases CDK5 accumulation in the nucleus, suppressing both cancer cell proliferation and xenograft tumorigenesis.
T11652	Indirubin-3'-monoxime-5-sulphonic acid	Others	Others
	Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of GSK-3β, CDK5, and CDK1 with IC50s of 80nM,5 nM, and 7 nM, respectively.
T22590	AT7519 TFA AT7519 trifluoroacetate	Others	Others
	AT7519 is a kinase inhibitor (IC50: 0.19, 0.044, 0.51, 0.067, 0.66 and 0.018 μM for CDK1/cyclinB, CDK2/CyclinA, CDK2/Cyclin E, CDk4/CyclinD1, CDK6/Cyclin D3, CDk5/p35).
T21377	Aloisine A
	Aloisine A is a potent and selective CDK/GSK-3 inhibitor. IC50 data of Aloisine A: Cdk1/cyclin B (IC50: 150nM), Cdk2/cyclin A (IC50: 120nM), Cdk2/cyclin E (IC50: 400nM), Cdk5/p25 (IC50: 200nM), Cdk5/p35 (IC50: 160nM), GSK-3α (IC50: 500nM), GSK-3β (IC50: 6
T24734	RP-106 RP 106
	RP-106 is an ATP-competitive inhibitor of CDK5/p25, CDK1/cyclin B, and GSK-3.
T25650	LDN-193665 LDN 193665,LDN193665
	LDN-193665 is a potent inhibitor of tau kinase. It acts by targeting CDK5/p25 and GSK3β.
T61890	(E/Z)-BIO-acetoxime
	(E/Z)-BIO-acetoxime 是有效的，选择性的GSK-3α/β 抑制剂。对于GSK-3α/β，CDK5/p25，CDK2/cyclin A 和CDK1/cyclin B 的IC50分别为10nM，2.4μM, 4.3μM, 63μM。
T62554	PPARγ phosphorylation inhibitor 1
	PPARγ phosphorylation inhibitor 1 (Compound 10) 是一种有效的 PPARγ结合剂 (IC50: 24 nM)，具有抗糖尿病效果。PPARγ phosphorylation inhibitor 1 对 CDK5 介导的 PPARγ Ser273 磷酸化表现出抑制作用 (IC50: 160 nM)，且几乎无 PPARγ 激动作用。
T62694	(S)-GFB-12811
	(S)-GFB-12811 (compound 596) 是一种选择性的、选择性的 CDK5 抑制剂 (IC50<10 nM)。(S)-GFB-12811 能够用于细胞周期进程、神经元发育、肿瘤发生的研究。
T60661	CP681301
	CP681301 是CDK5的有效抑制剂，具有抗增殖活性。CP681301 在果蝇中表现出抗肿瘤活性。CP681301 降低神经胶质瘤干细胞中 CD133、OLIG2、SOX2、KI67、pCDK5 蛋白水平的表达。CP681301 减少小鼠胶质瘤异种移植物的自我更新。
T11653	Indirubin-5-sulfonate	Others	Others
	Indirubin-5-sulfonate shows inhibitory activity against GSK-3β. Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1,
T62695	GFB-12811
	GFB-12811，一种具有高选择性的口服活性CDK5抑制剂，其IC50为2.3 nM。该化合物对其他CDK激酶(CDK1/2/6/7/9)表现出显著的选择性。
T63933	CDK1-IN-3
	CDK1-IN-3 (8g) 是一种选择性的 CDK1 抑制剂，能够作用于 CDK1 (IC50: 36.8 nM)，CDK2 (IC50: 305.17 nM) 和 CDK5 (IC50: 369.37 nM)。CDK1-IN-3 能够影响细胞周期，进而抑制癌细胞的生长，能够用于研究癌症。
T63080	CDK1-IN-4
	CDK1-IN-4 (10d) 是一种选择性的 CDK1 抑制剂，能够作用于 CDK1 (IC50: 44.52 nM)、CDK2 (IC50: 624.93 nM) 和 CDK5 (IC50: 135.22 nM)。CDK1-IN-4 能够影响细胞周期，进而对癌细胞的生长表现出抑制作用。CDK1-IN-4 能够用于研究癌症。

化合物

Cdk5 Substrate acetate

Cat.No: T37207L

Target: CDK

Cdk5 Substrate

Cat.No: T37207

Synonym: Cdk5 Substrate

CDK5 inhibitor 20-223

Cat.No: T36742

Synonym: CDK5 inhibitor 20-223

Cat.No: T40263

Synonym: CDK5-IN-1

GSK-3/CDK5/CDK2-IN-1

Cat.No: T35555

Synonym: GSK-3/CDK5/CDK2-IN-1

[pThr3]-CDK5 Substrate

Cat.No: TP1602

[pThr3]-CDK5 Substrate (TFA)

Cat.No: TP1660

Cat.No: T63184

[pThr3]-CDK5 Substrate TFA

Cat.No: T76031

Cat.No: T61362

Cat.No: T7426

Target: Apoptosis, GSK-3, CDK

Cat.No: T7167

Synonym: NG 95,(2R)-2-[[6-[(3-氯-4-羧基苯基)氨基]-9-(1-甲基乙基)-9H-嘌呤-2-基]氨基]-3-甲基-1-丁醇

Target: CDK, Parasite

PNU112455A hydrochloride

Cat.No: T8230

Synonym: PNU 112455A

Target: CDK

Cat.No: T2440

Synonym: SU-5607

Target: Apoptosis, Casein Kinase, CDK

Cat.No: TQ0068

Synonym: AT9311,LCQ-195

Target: CDK

Cat.No: T2095

Synonym: Roscovitine,R-roscovitine,CYC202

Target: CDK

GSK-3 inhibitor 4

Cat.No: T77341

Target: GSK-3, CDK

Cat.No: T2247

Synonym: 9-Bromopaullone,NSC-664704,9-溴-7,12-二氢吲哚并[3,2-D][1]苯并氮杂卓-6(5H)-酮

Target: GSK-3, CDK

GSK 3 Inhibitor IX

Cat.No: T1917

Synonym: BIO,GSK 3 IX,6-BIO,6-Bromoindirubin-3'-oxime,MLS 2052,6-bromoindirubin-3-oxime

Target: Apoptosis, GSK-3, Tyrosine Kinases, CDK

Cat.No: T1912

Synonym: SCH 727965,PS-095760

Target: Apoptosis, CDK

Indirubin-3'-monoxime

Cat.No: T5200

Synonym: 靛玉红-3' -单肟,Indirubin-3'-oxime

Target: GSK-3, Lipoxygenase, CDK

1-Azakenpaullone

Cat.No: T6358

Synonym: 1-氮杂坎帕罗酮,azakenpaullone

Target: GSK-3

Cat.No: T21588

Target: ERK, CDK

Cat.No: T36964

Synonym: CAY10554

Target: CDK

Cat.No: T23389

Synonym: SR 1664

Target: PPAR

Cat.No: T21720

Synonym: Cdk4/6 Inhibitor IV,CINK4

Target: CDK

Cat.No: T6787

Synonym: BIA,GSK-3 Inhibitor X

Target: Apoptosis, GSK-3, HSV

RGB-286638 free base

Cat.No: T2378

Target: GSK-3, MEK, JAK, CDK

Cat.No: T61439

Target: Beta Amyloid, BACE, CDK

Aminopurvalanol A

Cat.No: T22260

Target: CDK

PHA-767491 hydrochloride

Cat.No: T6940

Synonym: CAY10572,PHA-767491,PHA767491 HCl,CAY-10572 hydrochloride

Target: Apoptosis, GSK-3, CDK

Samuraciclib hydrochloride

Cat.No: T10898

Synonym: ICEC0942 hydrochloride,CT7001 hydrochloride

Target: Apoptosis, CDK

Cat.No: T2506

Synonym: AZD5438

Target: CDK

Cat.No: T2059

Synonym: NG-60

Target: Apoptosis, CDK, Autophagy

Cat.No: T14943

Target: VEGFR, CDK, PKC

5-Iodo-indirubin-3'-monoxime

Cat.No: T10172

Target: GSK-3, CDK

Cat.No: T71486

Indirubin-3'-monoxime-5-sulphonic acid

Cat.No: T11652

Target: Others

Cat.No: T22590

Synonym: AT7519 trifluoroacetate

Target: Others

Cat.No: T21377

Cat.No: T24734

Synonym: RP 106

Cat.No: T25650

Synonym: LDN 193665,LDN193665

(E/Z)-BIO-acetoxime

Cat.No: T61890

PPARγ phosphorylation inhibitor 1

Cat.No: T62554

Cat.No: T62694

Cat.No: T60661

Indirubin-5-sulfonate

Cat.No: T11653

Target: Others

Cat.No: T62695

Cat.No: T63933

Cat.No: T63080

Cat. No.	Product Name	Target	Signaling Pathways
TN3673	Clausine Z	CDK	Cell Cycle/Checkpoint
	Clausine Z exhibits inhibitory activity against cyclin-dependent kinase 5 (CDK5) and shows protective effects on cerebellar granule neurons in vitro.
T38441	Manzamine A hydrochloride
	Manzamine A hydrochloride is an orally active beta-carboline alkaloid that exhibits specific inhibitory effects on GSK-3β (IC50 = 10.2 μM) and CDK-5 (IC50 = 1.5 μM). Additionally, it targets vacuolar ATPases, leading to the inhibition of autophagy in pancreatic cancer cells. Manzamine A hydrochloride possesses antimalarial and anticancer properties, and also demonstrates potent activity against HSV-1[4].

天然产物

Cat.No: TN3673

Target: CDK

Manzamine A hydrochloride

Cat.No: T38441

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