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Search Results for " autophagy-in-1 "

83

抑制剂 & 化合物

10

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T62331	Autophagy-IN-1
	Autophagy-IN-1 是一种有效的细胞自噬 (autophagy) /线粒体自噬 (mitophagy) 抑制剂，能够阻断癌细胞内自噬体-溶酶体融合，并同时选择性地提高自噬通量发挥作用。Autophagy-IN-1 能够阻滞细胞周期，并诱导细胞凋亡 (apoptosis)。Autophagy-IN-1 在 HCT116 小鼠异种移植瘤模型中明显抑制肿瘤生长，且毒性低。Autophagy-IN-1 能够用于研究结直肠癌。
T12347	p38-α MAPK-IN-1	p38 MAPK; Autophagy	Autophagy; MAPK
	p38-α MAPK-IN-1 是一种 MAPK14 (p38-α) 抑制剂，在 EFC 置换试验和 HTRF 试验中 IC50 分别为 2300 nM 和 5500 nM。
T14860	CaMKII-IN-1	CaMK; Autophagy	Autophagy; Neuroscience
	CaMKII-IN-1是高效的 CaMKII 选择性抑制剂，IC50为63nM，对 CaMKIV, MLCK, p38a, Akt1,和 PKC 这些靶点几乎无作用。
T7015	Vps34-IN-1 VPS34-IN1	PI3K; Autophagy	Autophagy; PI3K/Akt/mTOR signaling
	Vps34-IN-1 (VPS34-IN1) 是一种有效且高度选择性的 Vps34 抑制剂，可调节自噬，IC50为4nM。
T38977	Autophagy-IN-C1 Autophagy-IN-C1
	Autophagy-IN-C1是一种含有尿素的金鸡纳生物碱衍生物。Autophagy-IN-C1 不仅诱导肝细胞癌（HCC）细胞凋亡，而且阻断自噬。
T23716	AMDE-1 AMDE 1	Autophagy	Autophagy
	AMDE-1 是一种自噬调节剂，以 Atg5 依赖性方式触发自噬。 AMDE-1 将 Atg16 募集到自噬体前位点并导致 LC3 脂化。
T9314	CC214-1	mTOR; Autophagy	Autophagy; PI3K/Akt/mTOR signaling
	CC214-1 是一种 mTOR 抑制剂，具有潜在的抗癌活性，抑制蛋白翻译，可诱导自噬 (autophagy)。 CC214-1 是探索 mTOR 激酶生物学的体外工具化合物，可用于研究骨髓瘤。
T1937	Spautin-1 Spautin 1	Apoptosis; DUB; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	Spautin-1是一种特异性自噬抑制剂，可抑制泛素特异性肽酶 USP10和 USP13，IC50s 约为0.6到0.7 μM。
T8808L	LYN-1604 dihydrochloride LYN-1604 2HCl（2216753-86-3 free base)	Apoptosis; Autophagy	Apoptosis; Autophagy
	LYN-1604 2HCl 是一种有效的 UNC-51 样激酶 1 激活剂，EC50值为 18.94 nM。LYN-1604 可研究三阴性乳腺癌。
T36994	MRT 67307 dihydrochloride	SIK	PI3K/Akt/mTOR signaling
	MRT 67307 dihydrochloride 是 IKKε 和 TBK-1 的双抑制剂，IC50 分别为 160 和 19 nM。MRT 67307 dihydrochloride 也可抑制 ULK1 和 ULK2，IC50 分别为 45 和 38 nM。MRT 67307 dihydrochloride 还抑制细胞自噬 (autophagy)。
TQ0057	AVE 0991	Others	Others
	AVE 0991 是血管紧张素-(1-7) [Ang-(1-7)] 的非肽类似物，是一种具有口服活性的 Mas 激动剂，对 [125I]-Ang-(1-7) 结合到牛主动脉内皮细胞膜有抑制作用，通过增强自噬来抑制星形胶质细胞介导的阿尔茨海默病神经炎症。
T73599	TSPO ligand-1	Autophagy	Autophagy
	TSPO ligand-1 对外周和中枢苯二氮卓受体有亲和力。TSPO ligand-1 是一种线粒体外膜跨膜结构域上与 AUTAC4 结合的蛋白，可诱导线粒体自噬 (autophagy) 促进胞内线粒体更新。TSPO ligand-1 参与胆固醇在胞内的转运，可作为脑损伤和神经变性的生物标志物。
T63399L	mTOR/HDAC-IN-1 HCl mTOR/HDAC-IN-1 HCl（2815286-02-1 Free base)	HDAC; mTOR	Chromatin/Epigenetic; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	mTOR/HDAC-IN-1 HCl 是一种有效的 mTOR 和 HDAC 双重抑制剂，具有潜在的抗炎、抗增殖、自噬和诱导凋亡作用，可用于研究癌症。mTOR/HDAC-IN-1 HCl 是一种有效的 mTOR 和 HDAC 双重抑制剂，具有潜在的抗炎、抗增殖、自噬和凋亡诱导作用，可用于研究癌症。
T40130	Nur77 modulator 1 Nur77 modulator 1	Others	Others
	Nur77 modulator 1 可与Nur77结合，KD 为 3.58 μM。它上调 Nur77 表达，介导Nur77亚细胞定位，诱导Nur77 依赖的内质网应激和自噬，可导致细胞凋亡，Nur77 modulator 1显示出抗肝癌生物活性。
T24167	Inflachromene ICM	Others	Others
	Inflachromene(ICM) 是一种 HMGB1 和 HMGB 表达抑制剂，具有抗炎活性。Inflachromene 通过抑制 HMGB1 易位来减轻小鼠癫痫模型的癫痫发作严重程度，通过 HMGB1/2 调节的 TLR4-NF-κB 通路抑制内膜增生，通过调节 Beclin 1 活性来抑制自噬。Inflachromene 可用于研究癫痫。
T2310L	CHIR-99021 HCl CT99021 HCl,Laduviglusib HCl	GSK-3	PI3K/Akt/mTOR signaling; Stem Cells
	CHIR-99021 HCl (Laduviglusib HCl) 是GSK-3α/β的高效选择性抑制剂，IC50值分别为10 nM和6.7 nM。它对GSK-3表现出显著的选择性，对CDC2、ERK2和其他蛋白激酶的选择性超过500倍。此外，CHIR-99021 HCl 是Wnt/β-catenin信号通路的强大激活剂。此外，它在小鼠和人类胚胎干细胞中都表现出增强自我更新的能力。此外，拉杜维格西单盐酸盐诱导自噬[1][2][3]。
T0097	MRT67307 MRT67307 HCl	IκB/IKK; Autophagy	Autophagy; NF-κB
	MRT67307 是一种IKKε和TBK-1的双抑制剂，IC50分别为 160 和 19 nM。它抑制细胞自噬，也可抑制ULK1和ULK2，IC50分别为 45 和 38 nM。
T61580	Autophagy inducer 3
	Autophagy Inducer 3 is a chemical compound that exhibits autophagy-induced activity, specifically inducing robust autophagic cell death in various cancer cells while sparing normal cells. This compound induces lethal autophagy through the formation of distinct autophagic vacuoles, LC3 puncta formation, and upregulation of signature autophagy markers such as Beclin and Atg family proteins [1].
T13889	SLLN-15	Others	Others
	SLLN-15 是一个具有口服活性的、选择性的、有效的自噬 (autophagy) 增强剂。SLLN-15 可激活三阴乳腺癌细胞的自噬。
T68813	NSC-18725
	NSC-18725 is a novel inhibitor of growth of intracellular Mycobacterium tuberculosis, inducing autophagy in differentiated THP-1 macrophages.
T38861	Tat-beclin 1
	Tat-beclin 1, a peptide derived from the autophagy protein beclin 1, is a powerful inducer of autophagy. It interacts with GAPR-1 (GLIPR2), a negative regulator of autophagy. Tat-beclin 1 effectively reduces the buildup of polyglutamine expansion protein aggregates and inhibits the replication of various pathogens, such as HIV-1, in laboratory experiments. In addition, it has demonstrated the ability to decrease mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV).
T61547	ATG7-IN-2
	ATG7-IN-2 (compound 1) is a highly potent inhibitor of the ATG7 protein, displaying an IC 50 value of 0.089 μM. This compound effectively suppresses the activity of autophagy marker LC3B, thereby regulating the autophagy process [1].
T76058	Tat-beclin 1 TFA
	Tat-beclin 1 TFA是一种来源于自噬蛋白区域(beclin 1)的肽，有效诱导自噬(autophagy)并与GAPR-1 (GLIPR2)发生相互作用，具有显著的自噬负调控作用。该化合物能有效减少体外聚谷氨酰胺扩增蛋白聚集体的积累，并抑制HIV-1等多种病原体的复制。同时，Tat-beclin 1 TFA能显著降低感染基孔肯雅病(CHIKV)或西尼罗河病毒(WNV)小鼠的死亡率。
T74304	C16 PEG-Ceramide
	C16 PEG-Ceramide为一种聚乙二醇化神经酰胺，具备脂质载体传递功能，并能诱导自噬(autophagy)，在癌症研究中有应用。
T74615	NAMPT degrader-1
	NAMPTdegrader-1 (Compound A3) 是一种酰胺磷酸核糖转移酶 (NAMPT) 降解剂，IC50为 0.023 μM。NAMPTdegrader-1 通过 autophagy-lysosomal 途径显著诱导 NAMPT 降解，表现出良好的细胞抗肿瘤能力。
T60749	Autophagy-IN-2
	Autophagy-IN-2 (Compound 7h) 是自噬通量的抑制剂，可诱导癌细胞凋亡，具有研究三阴性乳腺的潜力。
T10607	BRD5631	Autophagy	Autophagy
	BRD5631 是一种自噬 (autophagy) 增强剂，通过与 mTOR 无关的通路来增强自噬。BRD5631 能够影响先前与自噬相关的几种细胞疾病表型，包括蛋白聚集、细胞存活、细菌复制和炎性因子的产生。BRD5631可以作为一种有价值的工具，用于研究自噬在细胞稳态和疾病中的作用。
T73544	MPM-1
	MPM-1 是海洋生物 Eusynstyelamides 模拟物，是一种有效的抗癌剂。MPM-1 可通过诱导坏死样死亡，在体外快速杀死癌细胞。MPM-1具有诱导免疫原性细胞死亡的能力。MPM-1在癌细胞中干扰细胞自噬 (autophagy) 和溶酶体膨胀。
T61871	DC-LC3in-D5
	DC-LC3in-D5 is a chemical compound that functions as an autophagy inhibitor by diminishing the process of LC3B lipidation. It forms a binding association with LC3B, disrupting the LC3B-LBP2 interaction with an IC50 of 200 nM. This compound, DC-LC3in-D5, exhibits potential for application in anti-HCV or combination cancer treatments by effectively inhibiting autophagy [1].
T61659	CC214-2
	CC214-2 is a potent dual inhibitor of mTORC1 and mTORC2, known for its ability to impede autophagy by modulating mammalian target of rapamycin (mTOR) signaling. With this capacity, CC214-2 shows promise in shortening the duration of tuberculosis (TB) [1].
T78909	Antitumor agent-97	Apoptosis	Apoptosis
	Antitumor agent-97（化合物 42）是一种有效抑制MGC 803细胞增殖与自噬（autophagy）并诱导细胞凋亡（apoptosis）的抗癌剂。该化合物还可增强MGC 803细胞中ROS的积累，适用于癌症研究。
T61552	ATG7-IN-3
	ATG7-IN-3 (compound 18) is an effective inhibitor of ATG7, with a potency of 0.048 μM as determined by its IC50 value. It exhibits inhibitory actions on autophagy. Moreover, ATG7-IN-3 effectively hampers the development of endogenous LC3B puncta in the H4 neuroglioma cell line [1].
T61344	VO-OHPic
	VO-OHPic is a reversible, noncompetitive, and selective inhibitor of PTEN with an IC50 of 46 nM. It effectively attenuates apoptosis, adverse cardiac remodeling, and the presence of pro-inflammatory M1 macrophages in models of doxorubicin-induced cardiomyopathy. Additionally, VO-OHPic inhibits autophagy [1] [2] [3].
T79516	BT424	Src	Angiogenesis; Tyrosine Kinase/Adaptors
	BT424是一种特异性HCK抑制剂，能够调节体外巨噬细胞的活化及自噬，并在UUO模型中改善炎症和肾纤维化。
T60794	HDAC10-IN-1
	HDAC10-IN-1 (化合物 13b) 是一种有效且高选择性的HDAC10抑制剂 (IC 50 = 58 nM)，可用于调节侵袭性 FLT3-ITD 阳性急性髓系白血病细胞的自噬。
T61888	mTOR/HDAC6-IN-1
	mTOR/HDAC6-IN-1 是一种有效的组蛋白去乙酰酶 (HDAC6)和哺乳动物雷帕霉素 (mTOR) 的双重抑制剂，对于HDAC6 和 mTOR 的IC50值分别为56 nM 和133.7 nM。mTOR/HDAC6-IN-1 对细胞自噬 (autophagy)、细胞凋亡 (apoptosis)具有明显的诱导作用，对迁移具有抑制作用。mTOR/HDAC6-IN-1 在三阴性乳腺癌 (TNBC) 的研究中具有潜力
T79602	MTP	Autophagy	Autophagy
	MTP作为一种PKM2抑制剂，能够通过激活caspase-3来诱导癌细胞发生凋亡（apoptosis），同时诱导自噬（autophagy）过程并提高ROS的产生量。此外，MTP对JAK2信号传递通路也有抑制作用。该化合物主要用于研究口腔鳞状细胞癌。
T40785	Gefitinib impurity 1
	Gefitinib impurity 1 is a compound derived from Gefitinib, a potent and selective EGFR tyrosine kinase inhibitor (IC 50 = 33 nM). This orally active compound selectively inhibits tumor cell growth stimulated by EGF (IC 50 = 54 nM) and inhibits EGFR autophosphorylation induced by EGF in tumor cells. Additionally, Gefitinib induces autophagy and exhibits antitumor activity.
T60760	HDAC10-IN-2
	HDAC10-IN-2 (化合物 10c) 调节侵袭性 FLT3-ITD 阳性急性髓系白血病细胞的自噬。HDAC10-IN-2是HDAC10的高选择性抑制剂 (IC50 = 20 nM)。
T37085	Luxeptinib
	Luxeptinib (CG-806) is a novel pan-FLT3/pan-BTK inhibitor that is administered orally. It exhibits potent and reversible inhibition of these enzymes, acting through a non-covalent mechanism. Luxeptinib effectively induces cell cycle arrest, apoptosis, or autophagy in acute myeloid leukemia cells [1][2][3][4].
T79653	VISTA-IN-2	Autophagy	Autophagy
	VISTA-IN-2（Compound 1）是一种抑制V结构域Ig抑制因子（VISTA）的化合物，能够诱导通过自噬（Autophagy）机制的VISTA降解。该化合物在克制VISTA介导的免疫抑制方面有效，提升免疫细胞对抗肿瘤的活性，并在CT26小鼠肿瘤模型中激发抗肿瘤免疫响应，进而抑止肿瘤生长。
T18493	NH2-PEG5-C6-Cl	Others	Others
	NH2-PEG5-C6-Cl (K-7) is a PROTAC linker, which refers to the PEG composition. NH2-PEG5-C6-Cl can be used in the synthesis of a series of PROTACs, and it induces degradation of intracellular molecules by autophagy[1].
T35519	Aflatoxin B2-13C17 Aflatoxin B2-13C17
	Aflatoxin B2-13C17(AFB2-13C17) is intended for use as an internal standard for the quantification of AFB2by GC- or LC-MS. AFB2is a mycotoxin that has been found inA. terricola.1It induces hepatic autophagy and apoptosis in broiler chickens when administered at doses of 0.2, 0.4, and 0.8 mg/kg.2AFB2(0.5 and 1 mg/animal) also induces parenchymal cell hyperplasia in rats.3 1.Moubasher, A.H., el-Kady, I.A., and Shoriet, A.Toxigenic Aspergilli isolated from different sources in EgyptAnn. Nutr. Alimen...
T39309	Telaglenastat hydrochloride CB-839 hydrochloride
	Telaglenastat (CB-839) hydrochloride is a first-in-class, reversible, and orally active inhibitor of glutaminase 1 (GLS1). It selectively inhibits the splice variants of GLS1, specifically KGA (kidney-type glutaminase) and GAC (glutaminase C), as compared to GLS2. Telaglenastat hydrochloride has an IC50 of 23 nM for endogenous glutaminase in mouse kidney and 28 nM in the brain. In addition, it induces autophagy and exhibits antitumor activity.
T78404	Pyridinium bisretinoid A2E TFA A2E TFA	Apoptosis	Apoptosis
	Pyridinium bisretinoid A2E TFA作为一种荧光团，能从视网膜色素上皮(RPE)的脂褐素中分离得到，是蓝光诱导的细胞凋亡(apoptosis)诱导剂。该化合物具有光活化特性，可介导自噬(autophagy)和活性氧(reactive oxygen species)的产生，常用于视网膜退行性疾病的研究。
T73550	CUR5g
	CUR5g 是一种有效的自噬 (autophagy) 抑制剂。CUR5g 通过阻断自噬体-溶酶体融合选择性地抑制癌细胞中的自噬体降解。CUR5g 通过依赖 UVRAG 的机制阻止 STX17 募集到自噬体，导致自噬体无法与溶酶体融合。CUR5g 可提高顺铂 (Cisplatin) 在体外和体内对 A549 细胞的抗癌作用。
T72780	HSP90/mTOR-IN-1
	HSP90/mTOR-IN-1 是一种有效的Hsp90和mTOR 抑制剂，IC50分别为 69 nM 和 29 nM。HSP90/mTOR-IN-1 通过过度激活PI3K/AKT/mTOR 通路抑制 SW780 细胞增殖。HSP90/mTOR-IN-1 通过对HSP90和mTOR 的选择性抑制来诱导细胞凋亡 (apoptosis) 和细胞自噬 (autophagy)。HSP90/mTOR-IN-1 在异种移植小鼠体内也表现出良好的抗肿瘤活性。HSP90/mTOR-IN-1 可用于膀胱癌的研究。
T78145	HDAC10-IN-2 hydrochloride	Autophagy	Autophagy
	HDAC10-IN-2 hydrochloride（化合物10c）是一种对HDAC10具有高效性和高选择性的抑制剂，IC50值为20 nM。该化合物能够调控FLT3-ITD阳性急性髓系白血病细胞的自噬过程。
T79371	HDAC-IN-62	Autophagy	Autophagy
	HDAC-IN-62（Compound 5），是一款针对HDAC6/8/11的HDAC抑制剂，IC50分别为0.78、1.0、1.2μM。该化合物通过诱导自噬（Autophagy）来抑制微胶质细胞的激活，进而抑制一氧化氮产生，显示出抗炎和抗抑郁的效果。此外，HDAC-IN-62还能抑制实验小鼠大脑中的微胶质细胞活化。
T36991	Monascuspiloin
	Monascuspiloin is a fungal metabolite that has been found inM. pilosusM93-fermented rice.1It induces endoplasmic reticulum stress and autophagy in PC3 prostate cancer cells. Monascuspiloin (15-45 μM) decreases viability of PC3 cells and has an additive effect on the reduction in viability of PC3 cells induced by irradiation when used at a concentration of 25 μM. It induces intratumor apoptosis and autophagy and reduces tumor growth in a PC3 mouse xenograft model when administered at doses of 40 ...

化合物

Autophagy-IN-1

Cat.No: T62331

p38-α MAPK-IN-1

Cat.No: T12347

Target: p38 MAPK, Autophagy

Cat.No: T14860

Target: CaMK, Autophagy

Cat.No: T7015

Synonym: VPS34-IN1

Target: PI3K, Autophagy

Autophagy-IN-C1

Cat.No: T38977

Synonym: Autophagy-IN-C1

Cat.No: T23716

Synonym: AMDE 1

Target: Autophagy

Cat.No: T9314

Target: mTOR, Autophagy

Cat.No: T1937

Synonym: Spautin 1

Target: Apoptosis, DUB, Autophagy

LYN-1604 dihydrochloride

Cat.No: T8808L

Synonym: LYN-1604 2HCl（2216753-86-3 free base)

Target: Apoptosis, Autophagy

MRT 67307 dihydrochloride

Cat.No: T36994

Target: SIK

Cat.No: TQ0057

Target: Others

Cat.No: T73599

Target: Autophagy

mTOR/HDAC-IN-1 HCl

Cat.No: T63399L

Synonym: mTOR/HDAC-IN-1 HCl（2815286-02-1 Free base)

Target: HDAC, mTOR

Nur77 modulator 1

Cat.No: T40130

Synonym: Nur77 modulator 1

Target: Others

Cat.No: T24167

Synonym: ICM

Target: Others

Cat.No: T2310L

Synonym: CT99021 HCl,Laduviglusib HCl

Target: GSK-3

Cat.No: T0097

Synonym: MRT67307 HCl

Target: IκB/IKK, Autophagy

Autophagy inducer 3

Cat.No: T61580

Cat.No: T13889

Target: Others

Cat.No: T68813

Cat.No: T38861

Cat.No: T61547

Tat-beclin 1 TFA

Cat.No: T76058

C16 PEG-Ceramide

Cat.No: T74304

NAMPT degrader-1

Cat.No: T74615

Autophagy-IN-2

Cat.No: T60749

Cat.No: T10607

Target: Autophagy

Cat.No: T73544

Cat.No: T61871

Cat.No: T61659

Antitumor agent-97

Cat.No: T78909

Target: Apoptosis

Cat.No: T61552

Cat.No: T61344

Cat.No: T79516

Target: Src

Cat.No: T60794

mTOR/HDAC6-IN-1

Cat.No: T61888

Cat.No: T79602

Target: Autophagy

Gefitinib impurity 1

Cat.No: T40785

Cat.No: T60760

Cat.No: T37085

Cat.No: T79653

Target: Autophagy

Cat.No: T18493

Target: Others

Aflatoxin B2-13C17

Cat.No: T35519

Synonym: Aflatoxin B2-13C17

Telaglenastat hydrochloride

Cat.No: T39309

Synonym: CB-839 hydrochloride

Pyridinium bisretinoid A2E TFA

Cat.No: T78404

Synonym: A2E TFA

Target: Apoptosis

Cat.No: T73550

HSP90/mTOR-IN-1

Cat.No: T72780

HDAC10-IN-2 hydrochloride

Cat.No: T78145

Target: Autophagy

Cat.No: T79371

Target: Autophagy

Cat.No: T36991

Cat. No.	Product Name	Target	Signaling Pathways
TN6705	Graveoline 1-甲基-2- [3' ,4' - (亚甲二氧基)苯基] -4-喹诺酮,2-(Benzo[d][1,3]dioxol-5-yl)-1-methylquinolin-4(1H)-one,Foliosine	Autophagy	Autophagy
	Graveoline (2-(Benzo[d][1,3]dioxol-5-yl)-1-methylquinolin-4(1H)-one) 是皮肤黑色素瘤癌细胞的凋亡和自噬诱导剂。
TN6751	1-HEXACOSANOL	NPC1L1; AMPK	Chromatin/Epigenetic; Membrane transporter/Ion channel; PI3K/Akt/mTOR signaling
	1-HEXACOSANOL 激活 AMPK 和肝脏自噬并抑制 SREBP2，导致降胆固醇活性和肝脏脂肪变性的改善。
T4S1962	beta-Asarone β-细辛脑,(Z)-1,2,4-三甲氧基-5-丙烯基苯;顺式细辛脑,Cis-Isoasarone,Cis-Asarone,Cis-Isoelemicin	NF-κB; JNK	MAPK; NF-κB
	beta-Asarone (Cis-Isoelemicin) 是一种石菖蒲中的主要成分，具有免疫抑制、促进安定、中枢神经系统抑制、降温等功能。它可透过血脑屏障，能够预防帕金森病。
T8689	Chloroquine CQ,氯喹	SARS-CoV; TLR; HIV Protease; Antibiotic; Parasite; Autophagy	Autophagy; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Chloroquine 是一种 Toll 样受体抑制剂，可以抑制自噬。Chloroquine 具有抗疟疾和抗炎活性，广泛用于治疗疟疾和类风湿性关节炎。Chloroquine 还具有抗 SARS-CoV-2 (COVID-19) 活性、抗 HIV-1 活性。
T3S1471	Cucurbitacin IIA 葫芦素Iia,Dihydrocucurbitacin Q1,Hemslecin A,Curcurbitacin IIA	Apoptosis; Survivin	Apoptosis
	Cucurbitacin IIA (Dihydrocucurbitacin Q1) 是从园果雪胆中分离得到的一种三萜烯，可诱导细胞凋亡和增强自噬，有助于葫芦素IIA 对炎症相关疾病的抗炎活性。它可降低癌细胞中生存素的表达，降低磷酸化组蛋白 H3 的水平，增加裂解的 PARP 的水平。
TN1567	Delphinidin chloride	Estrogen Receptor/ERR; VEGFR	Angiogenesis; Endocrinology/Hormones; Tyrosine Kinase/Adaptors
	Delphinidin chloride 是一种花青素，是一种可从浆果和红酒中分离得到的天然植物色素，是某些花青素的前体。Delphinidin chloride 诱导血管内皮释放一氧化氮，引起血管松弛。在1 ~ 40 μM 剂量下，对上皮生长因子受体的信号传导和雌激素受体α的表达有抑制作用，与细胞凋亡和自噬有关。Delphinidin chloride 能调节 JAK/STAT3 和 MAPKinase 信号传导。Delphinidin 还能抑制 p300/CBP 的组蛋白乙酰转移酶活性(IC50 在约为30 μM)
TQ0258	Corynoxine B 柯诺辛碱 B,柯诺辛碱B	Autophagy	Autophagy
	Corynoxine B is a Beclin-1-dependent autophagy inducer. It is an natural alkaloid isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese).
T75484	Clionamine B
	Clionamine B, 一种海绵 Cliona celata 分离出来的刺激自噬的氨基类固醇，强烈刺激人乳腺癌 MCF-7 细胞的自噬。
T38441	Manzamine A hydrochloride
	Manzamine A hydrochloride is an orally active beta-carboline alkaloid that exhibits specific inhibitory effects on GSK-3β (IC50 = 10.2 μM) and CDK-5 (IC50 = 1.5 μM). Additionally, it targets vacuolar ATPases, leading to the inhibition of autophagy in pancreatic cancer cells. Manzamine A hydrochloride possesses antimalarial and anticancer properties, and also demonstrates potent activity against HSV-1[4].
T37452	Stephacidin B
	Stephacidin B is a fungal metabolite that has been found inA. ochraceus.1Dimeric stephacidin B is rapidly converted to a monomer, avrainvillamide ,in vitro.2Stephacidin B is cytotoxic to a variety of cancer cells, including testosterone-independent PC3 and -sensitive LNCaP prostate cancer cells (IC50s = 0.37 and 0.06 μM, respectively) and estradiol-independent SK-BR-3 and -sensitive MCF-7 breast cancer cells (IC50s = 0.32 and 0.27 μM, respectively).1It induces apoptosis in HepG2 and Huh7 hepatoc...

天然产物

Cat.No: TN6705

Synonym: 1-甲基-2- [3' ,4' - (亚甲二氧基)苯基] -4-喹诺酮,2-(Benzo[d][1,3]dioxol-5-yl)-1-methylquinolin-4(1H)-one,Foliosine

Target: Autophagy

Cat.No: TN6751

Target: NPC1L1, AMPK

Cat.No: T4S1962

Synonym: β-细辛脑,(Z)-1,2,4-三甲氧基-5-丙烯基苯;顺式细辛脑,Cis-Isoasarone,Cis-Asarone,Cis-Isoelemicin

Target: NF-κB, JNK

Cat.No: T8689

Synonym: CQ,氯喹

Target: SARS-CoV, TLR, HIV Protease, Antibiotic, Parasite, Autophagy

Cucurbitacin IIA

Cat.No: T3S1471

Synonym: 葫芦素Iia,Dihydrocucurbitacin Q1,Hemslecin A,Curcurbitacin IIA

Target: Apoptosis, Survivin

Delphinidin chloride

Cat.No: TN1567

Target: Estrogen Receptor/ERR, VEGFR

Cat.No: TQ0258

Synonym: 柯诺辛碱 B,柯诺辛碱B

Target: Autophagy

Cat.No: T75484

Manzamine A hydrochloride

Cat.No: T38441

Cat.No: T37452

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