50
11
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T60006 |
Aromatase inhibitor 23
|
Others | Others |
Aromatase inhibitor 23 是一种针对 RAD51 重组酶家族中蛋白质-蛋白质相互作用的抑制剂。 | |||
T60022 |
Aromatase-IN-2
|
Others | Others |
Aromatase-IN-2 具有抗炎、抗肿瘤和平喘作用。 | |||
T61444 | Nonsteroidal aromatase inhibitor 1 | ||
Nonsteroidal aromatase inhibitor 1 (Compound 13h) effectively inhibits the enzyme CYP19A1 with an IC50 value of 0.09 nM. Due to its potent inhibitory activity, Nonsteroidal aromatase inhibitor 1 holds promise for research in the field of breast cancer [1]. | |||
T7197 |
Fadrozole
|
Aromatase | Endocrinology/Hormones |
Fadrozole 是一种有效的、非甾体类的、选择性的芳香化酶抑制剂(IC50:6.4 nM)。 | |||
T61463 | Monoamine oxidase/Aromatase-IN-1 | ||
Monoamine oxidase/Aromatase-IN-1 (compound 2q) is a potent dual inhibitor of monoamine oxidase (MAO) and aromatase, with IC50 values of 39 nM and 31 nM for MAO-B and aromatase, respectively. It holds significant potential for research in neurological disorders and breast cancer [1]. | |||
T11991 |
Mefentrifluconazole
|
P450; Antifungal | Metabolism; Microbiology/Virology |
Mefentrifluconazole 是一种有效的、选择性的和具有口服活性的真菌 CYP51 (Kd= 0.5 nM) 抑制剂,但对人芳香酶的抑制活性较低,IC50值为0.92 μM。它是一种新型唑类衍生物,用作农用广谱抗真菌剂。 | |||
T0393 |
Anastrozole
阿那曲唑,ZD1033 |
Aromatase | Endocrinology/Hormones |
Anastrozole (ZD1033) 是芳香酶的选择性抑制剂,能够抑制胎盘芳香化酶(IC50:15 nM)。 | |||
T7556 |
Fadrozole hydrochloride
CGS 16949A,盐酸法倔唑 |
Aromatase | Endocrinology/Hormones |
Fadrozole hydrochloride (CGS 16949A) 是一种选择性的、有效,和非甾体类的芳香化酶抑制剂(IC50:6.4 nM)。 | |||
T1103 |
Aminoglutethimide
DL-Aminoglutethimide,氨鲁米特,BA-16038,NSC-330915 |
Aromatase | Endocrinology/Hormones |
Aminoglutethimide (BA-16038) 是一种芳香酶抑制剂,IC50=10 μM,用于治疗晚期 BREAST Y。 | |||
T20625 |
Prochloraz
咪鲜胺,Sporgon,Prelude |
Estrogen Receptor/ERR; AhR; Androgen Receptor; Antifungal | Endocrinology/Hormones; Immunology/Inflammation; Metabolism; Microbiology/Virology |
Prochloraz (Prelude) 是咪唑类抗真菌剂。Prochloraz 抑制羊毛甾醇的细胞色素 P450 依赖性 14α-脱甲基作用,由此抑制麦角固醇的生物合成,从而导致真菌细胞膜破裂和细胞死亡。它也是雌激素受体和 雄激素受体的拮抗剂,IC50分别为25 μM 和4 μM, 并激活芳烃受体,EC50为1μM。 | |||
T1587 |
Exemestane
EXE,依西美坦,FCE 24304,PNU155971 |
Aromatase | Endocrinology/Hormones |
Exemestane (EXE) 是一种选择性的、具有口服活性的、不可逆的甾体芳香酶抑制剂,能够作用于人胎盘芳香酶 (IC50:30 nM) 和大鼠卵巢芳香酶 (IC50:40 nM),可用于研究激素依赖性乳腺癌。 | |||
T4281 |
Endoxifen
(E/Z)-N-desmethyl-4-hydroxy Tamoxifen,N-去甲基-4-羟基-,(E/Z)-Endoxifen |
Estrogen Receptor/ERR; Aromatase; Estrogen/progestogen Receptor; Parasite; Drug Metabolite | Endocrinology/Hormones; Metabolism; Microbiology/Virology |
Endoxifen ((E/Z)-Endoxifen) 是 Tamoxifen 的关键活性代谢物,能抑制芳香酶的活性,与雌激素受体有较高的亲和力和特异性。它有潜力研究乳腺癌。 | |||
T71708 |
Minamestane
|
Aromatase | Endocrinology/Hormones |
Minamestane 是一种新型不可逆芳香化酶抑制剂。Minamestane 引起人胎盘芳香化酶的时间依赖性抑制,半衰期为4分钟,K 为59nM。Minamestane 具有抗肿瘤活性。 | |||
T27320 |
Finrozole
MPV 2213ad,MPV-2213ad,MPV 2213,MPV-2213,MPV2213ad |
Aromatase | Endocrinology/Hormones |
Finrozole (MPV 2213ad) 是一种新型选择性芳香化酶抑制剂,对于乳房发育是部分可逆的。 | |||
T23549 |
YM 511
|
P450; Aromatase | Endocrinology/Hormones; Metabolism |
YM 511 是一种高度特异性的非甾体芳香酶 (aromatase) 抑制剂。YM 511 竞争性抑制大鼠卵巢和人胎盘微粒体中的芳香酶活性 (IC50 分别为 0.4 和 0.12 nM)。YM 511 轻微抑制其他类固醇激素的产生。YM 511 具有用于抑制雌激素依赖性作用研究,不会影响其他类固醇激素的血清水平的潜力。 | |||
T2280 |
Endoxifen (Z-isomer)
Z-因多昔芬,Endoxifen Z-isomer,4-[(1E)-1-{4-[2-(甲基氨基)乙氧基]苯基}-2-苯基-1-丁烯-1-基]苯酚 |
Estrogen Receptor/ERR; EGFR; Potassium Channel; Estrogen/progestogen Receptor; HER | Angiogenesis; Endocrinology/Hormones; JAK/STAT signaling; Membrane transporter/Ion channel; Tyrosine Kinase/Adaptors |
Endoxifen Z-isomer (EDX)是 Tamoxifen 重要的代谢产物,在表达 ERα的乳腺癌细胞中发挥抗雌激素作用。它以浓度依赖的方式抑制 hERG, IC50值为1.6μM。 | |||
T72310 |
Antibacterial agent 132
|
Antifungal | Microbiology/Virology |
Antibacterial agent 132 对 C. parapsilosis (ATCC 22019) 和 C. krusei (ATCC 6258) 实验中显示出抗菌作用,MIC90 值分别为 <0.06 μg/mL 和 62.50 μg/mL。Antibacterial agent 132 对芳香化酶 (aromatase enzyme)具有抑制作用,IC50 为 0.047μM。 | |||
T27918 |
LY 43578
LY-43578,LY43578 |
P450; Aromatase | Endocrinology/Hormones; Metabolism |
LY 43578 是一种具有口服活性的芳香酶 (aromatase) 抑制剂。LY 43578 对大鼠肝微粒体 P-450依赖的 p-nitroanisole 的 O -去甲基化和 ethylmorphine 的 N -去甲基化有抑制作用,IC50 分别为 0.3 和 5 μΜ。LY 43578 可用于研究神经系统疾病和心血管疾病。 | |||
T26322 |
Vorozole
R83839,R 83839,R-83839,(+)-Vorozole,R83842 |
P450; Aromatase | Endocrinology/Hormones; Metabolism |
Vorozole (R83842) 是一种具有口服活性、有效性和选择性的非甾体芳香酶抑制剂。Vorozole 在体内表现出抗肿瘤活性,可用于研究乳腺癌。 | |||
T26322L |
(-)-Vorozole
(-)-Vorozole(Isomer-129731-10-8) |
P450; Aromatase | Endocrinology/Hormones; Metabolism |
(-)-Vorozole 是一种具有口服活性的非甾体芳香酶抑制剂,具有有效性和选择性。(-)-Vorozole在体内实验中表现出抗肿瘤活性。(-)-Vorozole 可用于研究乳腺癌。 | |||
T6827L |
Endoxifen hydrochloride
|
||
Endoxifen hydrochloride,Tamoxifen的主要活性代谢产物,具备较高的对雌激素受体(estrogen receptor)的亲和力和特异性,并能抑制芳香酶活性。它在乳腺癌研究中表现出潜在应用价值。 | |||
T11847L |
Liarozole
R75251 dihydrochloride,利阿唑 |
P450; Retinoid Receptor | Metabolism |
Liarozole (R75251 dihydrochloride) 是一种咪唑衍生物,是一种具有口服活性的维甲酸 (RA) 代谢阻断剂(RAMBA),具有抗肿瘤作用。它能够抑制维甲酸依赖的细胞色素P450(CYP26) 4- 羟基化 (IC50=7 μM),导致组织维甲酸水平增加。 | |||
T70558 |
Org 33201
|
||
Org 33201 is a potent aromatase inhibitor. | |||
T27868 |
LY 113174
LY-113174,LY113174 |
||
LY 113174, a novel nonsteroidal aromatase inhibitor, may prove useful in the treatment of estrogen-dependent diseases. | |||
T71897 |
Vatalanib succinate
|
||
Vatalanib succinate is a VEGFR, PDGFR-β, c-Kit, c-Fms, and aromatase inhibitor. | |||
T27369 |
FR 901537
FR901537,FR-901537 |
||
FR 901537 is a new aromatase inhibitor with antitumor effects. | |||
T70404 |
MPV-2213AD
|
||
MPV-2213AD is an aromatase inhibitor. | |||
T20683 |
Letrozole related compound B
Letrozole specified impurity A |
||
Letrozole related compound B is an impurity of aromatase inhibitor. | |||
T71410 | Cgs 18320B | ||
Cgs 18320B is a non-steroidal aromatase inhibitor | |||
T7197L |
Fadrozole HCl hydrate
Fadrozole,CGS-16949A,Fadrozole hydrochloride hemihydrate,CGS16949A,CGS 16949A |
||
Fadrozole is a selective inhibitor of aromatase. It also effective in the treatment of estrogen-dependent diseases including breast cancer. | |||
T27922 |
LY 56110
LY56110,LY-56110 |
||
LY 56110 is a novel nonsteroidal aromatase inhibitor. | |||
T25716 |
Liarozole fumarate
Liazal,R85246,R-85246,R 85246 |
||
Liarozole fumarate is used as a retinoic acid metabolism blocking agent (RAMBA) and an aromatase inhibitor. | |||
T12319 |
Org30958
|
Aromatase | Endocrinology/Hormones |
Org30958 is a potent inhibitor of aromatase in vivo. | |||
T30837 |
Cgp 47645
Leflutrozole,Cgp-47645,Cgp47645 |
||
CGP 47645 (Leflurozole) is an oral active non-steroidal aromatase inhibitor and antitumor agent with anti-tumor and endocrine effects. | |||
T30834 |
Cgp 45688
Cgp45688,Cgp-45688 |
||
CGP 45688 is an oral active non-steroidal aromatase inhibitor with anti-tumor and endocrine effects on rat breast tumors. | |||
T61787 |
SYN20028567
|
||
SYN20028567, an aromatase (CYP19) inhibitor, exhibits an IC50 value of 9.4 nM. It has potential applications in breast cancer research [1]. | |||
T81012 |
Testololactone
|
||
Testololactone,一种芳香酶抑制剂,常用于乳腺癌研究。 | |||
T71073 |
Tan 931
|
||
Tan 931 is a nonsteroidal aromatase inhibitor that was first isolated from the culture filtrate of a soil isolate fungus, No. 8974 | |||
T6060L |
Anabasine HCl
BB-NC-0036,CCG-38440,H-8174,AR-1H7273,ZX-BK000320,ST-24041653 |
||
Anabasine HCl is used as a clinical biomarker for tobacco smoke exposure and as an insecticide. It is also a depolarizing NMJ blocker, aromatase inhibitor, nAChr antagonist, and teratogen found in species of Nicotiana. | |||
T38424 |
(R)-Fadrozole
FAD286,(R)-CGS 16949A free base,(R)-Fadrozole |
||
(R)-Fadrozole ((R)-CGS 16949A; FAD286) is a potent nonsteroidal inhibitor. (R)-Fadrozole also inhibits human placental aromatase (pIC 50 = 6.17) and aldosterone biosynthesis. (R)-Fadrozole reverses cardiac fibrosis in spontaneously hypertensive heart failure rats.. | |||
T71010 |
Norendoxifen
|
||
Norendoxifen, also known as 4-hydroxy-N, N-didesmethyltamoxifen, is a nonsteroidal aromatase inhibitor of the triphenylethylene group that was never marketed. It is an active metabolite of the selective estrogen receptor modulator tamoxifen. | |||
T80057 |
Cytochrome P450 reductase
|
||
Cytochrome P450reductase,一种NADPH-细胞色素还原酶,发挥作用于促进芳香酶构象,以最适合底物结合。 | |||
T61919 | Anticancer agent 78 | ||
Anticancer agent 78 具有抗芳香酶活性(IC50= 0.9 μM)。Anticancer agent 78 是一种有效的抗癌剂,显示细胞毒性。Anticancer agent 78 在乳腺癌中有研究潜力。 | |||
T35676 |
17β-hydroxy Exemestane
|
||
17β-hydroxy Exemestane is the primary active metabolite of exemestane . It is formed by metabolism of exemestane by the cytochrome P450 (CYP) isoforms CYP1A and CYP4A11. 17β-hydroxy Exemestane is an aromatase inhibitor (IC50 = 69 nM using human placental microsomes) and an androgen receptor (AR) agonist (IC50 = 39.6 nM) that is selective for AR over estrogen receptor α (ERα; IC50 = 21.2 μM). It stimulates growth of AR- and ERα-positive MCF-7 (EC50 = 2.7 μM) and T47D breast cancer cells (EC50s = ... | |||
T11847 |
Liarozole dihydrochloride
R75251 dihydrochloride |
Others | Others |
Liarozole dihydrochloride is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 17 ,20-lyase).Liarozole dihydrochloride is an imidazole derivative; it is being investigated as a non-hormonal agent in prostate cancer and in the treatment of various other cancers and skin disorders. | |||
T37560 |
Nidulin
|
||
Nidulin is a depsidone originally isolated from A. nidulans. It is active against the bacteria M. tuberculosis and M. ranoe, as well as the fungi T. tonsurans and M. audouini. It also inhibits the growth of methicillin-resistant S. aureus (MRSA; MIC = 4 μg/ml) and has larvicidal activity toward Artemia (LC50 = 2.8 μg/ml). Nidulin is cytotoxic to MOLT-3 cells (IC50 = 21.2 μM) but not HuCCA-1, HepG2, or A549 cells (IC50s = >112.7 μM). It inhibits aromatase with an IC50 value of 11.2 μM. | |||
T25716L |
Liarozole HCl
R75251,Liarozole hydrochloride,R 75251,R-75251 |
||
Liarozole HCl is a benzimidazole derivative with antineoplastic activity. As a retinoic acid metabolism blocking agent, liarozole inhibits CYP450-dependent all-trans-retinoic acid (ATRA)-4-hydroxylase, leading to an increase in endogenous ATRA production, | |||
T83907 |
10-Chloroestra-1,4-diene-3,17-dione
10-chloro-1,4-Estradiene |
||
10-Chloroestra-1,4-diene-3,17-dione 是一个对雌性激素受体α (ERα) 具有激动作用的类固醇。它能增加在S. cerevisiae 中报告基因的表达(对人类受体的EC50 = 0.36 nM)。同时,它也是一种芳香化酶抑制剂(IC50 = 2.4 µM)。 | |||
T78590 |
Dibenzylfluorescein
DBF |
||
Dibenzylfluorescein(DBF)是一款荧光探针,作为细胞色素P450(CYP)亚型,包括CYP3A4、CYP2C8、CYP2C9、CYP2C19和CYP19的特异性底物,常在Km值0.87-1.9 µM(Ex=485nm,Em=535nm)范围内应用。该探针主要用于监测药物或疾病导致的CYP催化活性变化。 | |||
T71578 | Endoxifen mesylate | ||
Endoxifen, also known as N-desmethyl-4-hydroxytamoxifen, is a chemical that is under development for estrogen receptor-positive breast cancer. It is also being evaluated as an antipsychotic for treatment of mania and other psychotic disorders. Endoxifen is a nonsteroidal selective estrogen receptor modulator (SERM) of the triphenylethylene group. It is an active metabolite of tamoxifen and has been found to be effective in patients that have failed previous hormonal therapies (tamoxifen, aromat... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7999 |
7-Hydroxyflavanone
|
Anti-infection | Microbiology/Virology |
7-Hydroxyflavanone 对肺炎链球菌临床分离株显示出抗菌活性。 | |||
T1590 |
Letrozole
CGS 20267,来曲唑 |
Aromatase; Autophagy | Autophagy; Endocrinology/Hormones |
Letrozole (CGS 20267) 是一种可口服的,选择性可逆的非甾体类芳香化酶抑制剂,IC50值为 11.5 nM。它选择性抑制雌激素的生物合成,可研究乳腺癌。 | |||
T6917 |
Oleuropein
洋橄榄苦甙,橄榄苦苷 |
Apoptosis; Aromatase; ROS; PPAR | Apoptosis; DNA Damage/DNA Repair; Endocrinology/Hormones; Immunology/Inflammation; Metabolism |
Oleuropein 在橄榄叶和油中发现的天然产物,通过 p53 依赖性途径以及 Bax 和 Bcl2基因的调控来诱导乳腺癌细胞凋亡,还抑制芳香化酶。它可通过直接抑制 PPARγ转录活性来发挥抗氧化,抗炎和抗动脉粥样硬化作用。 | |||
T2O2744 |
alpha-Naphthoflavone
苯并黄素;α-萘黄酮;7,8-苯并黄酮,7,8-benzoflavone,α-萘黄酮 |
Aromatase | Endocrinology/Hormones |
alpha-Naphthoflavone (7,8-benzoflavone) 是合成的黄酮类化合物,是一种竞争性芳香酶抑制剂,其IC50=0.5 μM,Ki=0.2 μM。 | |||
TN3987 |
Eriodictyol chalcone
|
Anti-infection; Aromatase | Endocrinology/Hormones; Microbiology/Virology |
Eriodictyol chalcone 具有抗芳香化酶和抗 17β-HSD 的活性。它对恶性疟原虫的生长具有抗疟原虫作用。 | |||
T0530 |
Flavanone
2-Phenyl-4-chromanone,4-Flavanone,2,3-Dihydroflavone,黄烷酮,2-Phenylchroman-4-one |
Others; Aromatase | Endocrinology/Hormones; Others |
Flavanone (2-Phenylchroman-4-one) 是天然的黄酮类化合物,对人类雌激素合成酶芳香化酶具有抑制作用。 | |||
T3390 |
Obacunone
|
Apoptosis; Aromatase; p38 MAPK | Apoptosis; Endocrinology/Hormones; MAPK |
Obacunone 是从沼泽白葡萄柚种子中分离得到的,通过诱导凋亡发挥抗癌作用。它在雄激素依赖性人前列腺 Y 细胞中具有细胞毒性。它对鼠伤寒沙门氏菌具有抗毒作用,可作为开发鼠伤寒沙门氏菌抗毒策略的先导化合物。 | |||
T3899 |
Calceolarioside B
Desrhamnosyl isoacteoside,木通苯乙醇苷 B,Nuomioside A,木通苯乙醇苷B |
Aromatase | Endocrinology/Hormones |
Calceolarioside B (Desrhamnosyl isoacteoside) 是一种分离自Stauntonia hexaphylla 叶片中的天然产物。它抑制 DPPH 自由基清除活性(IC50:94.60 μM)。它显著抑制大鼠晶状体醛糖还原酶(RLAR)活性(C50:23.99 μM。 | |||
TN1674 |
Garcinone D
伽升沃 D |
Reactive Oxygen Species; Nrf2; STAT | Immunology/Inflammation; JAK/STAT signaling; Metabolism; NF-κB; Stem Cells |
Garcinone D 是来自山竹的一种呫吨酮,可促进 C17.2 神经干细胞的增殖。它以浓度和时间依赖的方式增加磷酸化信号转导和转录激活因子 3 (p-STAT3)、Cyclin D1 和核因子红细胞 2 相关因子 (Nrf2)、以及血红素加氧酶-1 (HO-1) 的蛋白质水平。 | |||
TN4605 | Myriceric acid B | HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Myriceric acid B is a potent HIV-1 entry inhibitor targeting gp41 and can serve as a lead compound for developing novel anti-HIV-1 drug. Myriceric acid B scavenges DPPH free radicals with IC50 value of 21.8 uM, it inhibits aromatase activity with IC50 val | |||
TN4307 | Isolimonexic acid | BCL; Caspase; COX; p53 | Apoptosis; Immunology/Inflammation; Neuroscience; Proteases/Proteasome |
Isolimonexic acid exhibits cytotoxicity on MCF-7 cell lines, it also inhibits Panc-28 cancer cell growth. |