95
26
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1909 |
L-701324
7-氯-4-羟基-3-(3-苯氧基)苯基-2(1H)-喹啉,L701324 |
NMDAR; iGluR | Membrane transporter/Ion channel; Neuroscience |
L-701324 是一种 NMDA 受体,对甘氨酸位点具有高亲和力和选择性,用作口服活性和长效抗惊厥药。 | |||
T4118 |
SB 271046 hydrochloride
SB 271046A |
5-HT Receptor | GPCR/G Protein; Neuroscience |
SB 271046 hydrochloride (SB 271046A) 是高效、选择性和具有口服活性的5-HT6受体拮抗剂,对大鼠、猪和人的pKi 分别为 9.02、8.55 和 8.81。它增加额叶皮层中的细胞外天冬氨酸和谷氨酸并表现出抗惊厥活性,EC50为 0.16 μM。它对 5-HT6 受体、结合位点和离子通道的选择性超过 200 倍。 | |||
TP2058L |
Catestatin acetate
Catestatin acetate(142211-96-9 free base) |
Endogenous Metabolite; AChR | Metabolism; Neuroscience |
Catestatin acetate 是 nAChR 的非竞争性拮抗剂,可抑制儿茶酚胺的释放。 Catestatin acetate 调节心脏功能和血压。 | |||
T38565 |
Testosterone glucuronide
|
Others | Others |
Testosterone glucuronide 是睾酮的主要尿液代谢物,是一种潜在的尿液生物标记物。 | |||
T9170 |
Testosterone decanoate
|
Others | Others |
Testosterone decanoate 是天然存在的雄激素睾酮酯,具有长效男性抗生育活性。 | |||
T9035 |
Testosterone undecanoate
|
Others; Androgen Receptor | Endocrinology/Hormones; Others |
Testosterone undecanoate 是一种睾酮酯,是睾酮的代谢产物,睾酮是很有前途的男性激素避孕雄激素。 | |||
TP2058 |
Catestatin
|
||
Non-competitive nicotinic cholinergic antagonist; selectively inhibits nicotinic-stimulated catecholamine secretion from chromaffin cells and noradrenergic neurons (IC50 ~ 200 nM). Blocks nicotinic-induced cationic signaling (IC50 ~ 200 - 250 nM) and inhi | |||
T81012 |
Testololactone
|
||
Testololactone,一种芳香酶抑制剂,常用于乳腺癌研究。 | |||
T28952 |
Testosterone glucoside
|
||
Testosterone glucoside is an androgen receptor agonist. | |||
T70409 |
6alpha-Fluorotestosterone
|
||
6alpha-Fluorotestosterone is a synthetic nonaromatizable androgen analog of testosterone. It binds to and activates specific nuclear receptors inhibits and is equipotent to testosterone. | |||
T34303 |
Retrotestosterone
Lumitestosterone |
||
Retrotestosterone, a biochemical, can affect testosterone. | |||
T75878 |
Catestatin TFA
|
||
Catestatin TFA,一个含有21个氨基酸残基、阳离子性疏水性肽,作为内源性肽,调节心脏功能及血压。它通过烟碱型乙酰胆碱受体(nAChRs)以非竞争性方式抑制儿茶酚胺释放,功能为烟碱类拮抗剂。 | |||
T34814 |
Testosterone, amidinohydrazone
V-2052,V2052,V 2052 |
||
Testosterone, amidinohydrazone is a biochemical. | |||
T13921 |
Testosterone tridecanoate
|
Others | Others |
Testosterone tridecanoate is a prodrug of testosterone. Testosterone is an anabolic steroid and primary male sex hormone. | |||
T34104 |
Polybutester
XM 72,XM72,XM-72 |
||
Polybutester is a biochemical. | |||
T34813 |
Testosterone ketolaurate
Testosterone 3-oxododecanoate,Testosteroni ketolauras,十二酮酸睾酮 |
||
Testosterone ketolaurate is an androgen and anabolic steroid and a testosterone ester. | |||
T64512 | Deoxyribonucleic Acid Sodium (Salmon testes) | ||
Deoxyribonucleic Acid Sodium (Salmon testes) is a natural DNA used in studies of DNA binding agents that modulate DNA structure and function. | |||
T40653 | Testosterone phenylacetate | ||
Testosterone phenylacetate, an analogue of Testosterone, is an androgen. | |||
T38572 |
Testosterone buciclate
|
||
Testosterone buciclate, a long-acting androgen ester, shows promise as a research agent for male hypogonadism. | |||
T4582 |
xanthanol
NSC 4038,占吨氢醇 |
Others | Others |
Xanthanol(NSC 4038) 用于测试血液中的尿素水平。 | |||
T5474 |
D159687
D 159687 |
PDE | Metabolism |
D159687 是一种PDE4D 选择性抑制剂。 | |||
T3956 |
Sodium ionophore III
ETH2120 |
Sodium Channel | Membrane transporter/Ion channel |
Sodium ionophore III (ETH2120) 是一种Na+载体,适用于测定血液、血浆、血清中的钠活性。 | |||
T14529 |
Bentiromide
|
Others | Others |
Bentiromide 是一种可被胰腺分泌的胰凝乳蛋白酶分解的多肽。Bentiromide 通过胰凝乳蛋白酶功能的体外试验确认胰腺外分泌功能。 | |||
T18929 |
Bromobimane
Monobromobimane |
Autophagy | Autophagy |
Bromobimane (Monobromobimane) 是一种非荧光物质,但与硫醇反应反应时生成荧光产物。Bromobimane 可被当作一种探针使用,常在临床医学上检验血液中硫化物的含量。 | |||
T14996 |
Congo Red
刚果红,Direct Red 28 |
Others | Others |
Congo Red (Direct Red 28) 是偶氮染料指示剂,在 pH 3.0的环境下呈紫罗兰色,在 pH5.0的环境下呈红色,常用于组织切片中淀粉样蛋白的测定。 | |||
T0734 |
Antipyrine
安替比林,Phenazone,Phenazon |
COX | Immunology/Inflammation; Neuroscience |
Antipyrine (Phenazone) 是一种退烧剂和止痛剂。它可用作氧化药物代谢的探针药物,常用于评估人类的肝氧化能力。 | |||
T0293 |
Metyrapone
美替拉酮,甲吡酮,NSC-25265,Su-4885 |
Others; P450; Dehydrogenase; Autophagy | Autophagy; Metabolism; Others |
Metyrapone (NSC-25265) 是 STEROID 11-BETA-MONOOXYGENASE 酶抑制剂。 它被用作库欣综合征诊断中下丘脑-垂体反馈机制的测试。 | |||
T37825 |
CAY10434
|
P450 | Metabolism |
CAY10434是一种有作用的 CYP4A 羟化酶 (CYP4A hydroxylase) 抑制剂,在人肾微粒体测试中的 IC50值为8.8 nM。CAY 10434 在改善血管紧张素 II 的收缩过程中 Emax 为 6764 mg。 | |||
T67810 |
Tampramine
|
Norepinephrine | Neuroscience |
Tampramine 是一种选择性去甲肾上腺素再摄取抑制剂,对肾上腺素能、组胺能和毒蕈碱受体显示出较低的亲和力。Tampramine 是治疗强迫游泳测试(FST)抑郁症的候选化合物。 | |||
T3312 |
AM-2394
AM2394 |
Glucokinase | Metabolism |
AM-2394 是新型的 glucokinase 激活剂 (GKA)。它能够激活葡萄糖激酶 (GK),EC50=60 nM。 | |||
T67811 |
Tefludazine
|
||
Tefludazine 一种具有苯茚酮结构的新型神经抑制剂, 是一种具有良好口服活性且与多巴胺和5-羟色胺受体有拮抗作用的化合物。Tefludazine 在小鼠、大鼠和狗的体外和体内测试模型中表现出强大的多巴胺(DA)拮抗活性。Tefludazine 是一种用来治疗精神类疾病的潜在化合物。 | |||
T37816 |
SB 243213
|
||
SB 243213 is an orally active, selective and high-affinity 5-HT2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 shows greater than a 100-fold selectivity over a wide range of neurotransmitter receptors, enzymes and ion channels. SB 243213 has improved anxiolytic profile and has the potential for schizophrenia and motor disorders[1]. SB 243213 shows little affinity (pKi<6) for cloned human 5-HT1A, 5-HT1B, 5-HT1E, 5- HT1F and 5-HT7 receptors. It shows... | |||
T68123 |
Oxodipine
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Oxodipine 是一种二氢吡啶型钙拮抗剂 ,抑制了KCl 诱导的兔主动脉收缩,降低了效力较低的大鼠心室试纸收缩的心脏力量。在大鼠培养的新生儿心室肌细胞中,Oxodipine 降低了L 型Ca 电流(I),IC 为0.24μM,对T 型Ca 电流(I)的IC 为0.41μM。Oxodipine 会使小鼠便秘和狗牙龈增生。 | |||
T38192 |
Unifiram
|
Others | Others |
Unifiram 是一种认知增强剂。 Unifiram 诱导大鼠海马 CA1 区场兴奋性突触后电位 (fEPSP) 幅度的持久增加 (EC50= 27 nM) 并增加大鼠大脑皮层中乙酰胆碱 (ACh) 的释放。 | |||
T37190 |
L-Allylglycine
|
Dehydrogenase; GABA Receptor | Membrane transporter/Ion channel; Metabolism; Neuroscience |
L-Allylglycine 是 GABA 合成酶(谷氨酸脱羧酶)的有效抑制剂。 | |||
T30911 |
Chromozym U
|
||
Chromozym U can be used as a chromogenic substrate test for urokinase in Shigella. | |||
T29358 |
2-Nitrobenzaldehyde
|
||
2-Nitrobenzaldehyde can be used for fluorescent immunochromatographic strip test | |||
T20408 |
Dimethylglyoxime
AI314925,AI3 14925,AI3-14925 |
||
Dimethylglyoxime is a compound that is used in the nickel spot test. | |||
T38209 | Hodgkinsine | ||
Hodgkinsine is a pyrrolidinoindoline alkaloid that has been found inP. colorataand has analgesic activity.1It increases latency to paw licking in the hot plate test and latency to tail withdrawal in the tail-flick test in mice when administered at a dose of 5 mg/kg. 1.Amador, T.A., Verotta, L., Nunes, D.S., et al.Antinociceptive profile of hodgkinsinePlanta Med.66(8)770-772(2000) | |||
TNU0657 |
MEGA-8
|
||
Bio-reagent, fine chemical, carbohydrate; for test strip and diagnostic | |||
T0293L |
Metyrapone Tartrate
SU 4885,Metopirone tartrate,SU-4885,SU4885 |
||
Metyrapone Tartrate is an inhibitor of the STEROID 11-beta-monooxygenase enzyme which is used as a test for feedback hypothalamic-pituitary mechanism in the diagnosis of Cushing SYNDROME. | |||
T27744 |
KRM-II-81
KRM-II81,KRM-II 81 |
||
KRM-II-81 is a γ-Aminobutyric Acid Type A (GABAA) Receptor Ligand. KRM-II-81 exhibits improved anxiolytic-like effects in a mouse marble burying assay and a rat Vogel conflict test. | |||
T70292 |
DDPM-2571 HCl
|
||
DDPM-2571 is a highly potent and in vivo active inhibitor of GABA transporter subtype 1 with anticonvulsant, anxiolytic, antidepressant and antinociceptive properties. DDPM-2571 was quickly distributed into the brain and was highly effective in the prevention of chemically-induced seizures (pentylenetetrazole and pilocarpine models) and 6-Hz convulsions. It demonstrated significant anxiolytic-like and antidepressant-like properties. DDPM-2571 had antinociceptive properties, both in the hot plate... | |||
T4305 |
8-OH-Dpat
8-Hydroxy-DPAT |
5-HT Receptor | GPCR/G Protein; Neuroscience |
8-OH-Dpat (8-Hydroxy-DPAT) 是选择性5-HT 激动剂,对 5-HT1A 的pIC50值为 8.19,对 5-HT7 的Ki 值为 466 nM,对 5-HT1B (pIC50, 5.42) 和 5-HT (pIC50<5) 的作用很弱。 | |||
TNU0270 | 5-Iodo-2’,3’-dideoxyuridine | ||
Nucleoside Derivatives - 2’,3’-Dideoxy nucleosides; Halo-nucleosides; 5-Modified pyrimidine nucleosides; Drugs and Inhibitors; 气管炎病毒检定tracheitis virus test。治疗单纯疱诊性病毒角膜炎herpes simplex keratitis drug | |||
T71251 |
DS-1558
|
||
DS-1558 is a potent and orally available GPR40 agonist.DS-1558 was found to have potent glucose lowering effects during an oral glucose tolerance test in ZDF rats. DS-1558 significantly and dose-dependently improved hyperglycemia and increased insulin secretion during the oral glucose tolerance test in Zucker fatty rats, the model of insulin resistance and glucose intolerance. DS-1558 not only increased the glucose-stimulated insulin secretion by GLP-1 but also potentiated the maximum insulinog... | |||
T68463 |
BI-4834
|
||
BI-4834 is a potent and selective Polo-like kinase 1 (PLK1) inhibitor. BI-4834 is also analogue (or Me-Too) of BI-2536. In vitro test shows that BI 4834 inhibits PLK1 with IC50=7.6 nm, but with higher selectivity over the related enzyme PLK3 (IC50 198.4 nm) as BI-2536. | |||
T38210 |
Hodgkinsine B
|
||
Hodgkinsine B is an alkaloid and isomer of hodgkinsine that has analgesic activity.1It increases the latency to tail withdrawal in the tail-flick test in mice when administered at a dose of 10 mg/kg. 1.Kodanko, J.J., Hiebert, S., Peterson, E.A., et al.Synthesis of all low-energy stereoisomers of the tris(pyrrolidinoindoline) alkaloid hodgkinsine and preliminary assessment of their antinociceptive activityJ. Org. Chem.72(21)7909-7914(2007) | |||
T27363 |
FR 64822
FR-64822,FR64822 |
||
FR64822(N-(4-pyridylcarbamoyl)amino 1,2,3,6,-tetrahydropyridine), a novel non-opioid antinociceptive compound, displays antinociceptive activities in a variety of assays with mice and rats. It has a strong antinociceptive activity in the acetic acid writh | |||
T37788 |
Resorufin benzyl ether
|
||
Resorufin benzyl ether is a fluorometric probe that acts as a substrate for cytochrome P450 (CYP)3A4. It is typically used near its apparent Km value of 30 μM to screen the inhibition/activation potential of test compounds, to predict potential drug-drug interactions, or to monitor other CYP450 activities. Upon enzyme cleavage, resorufin benzyl ether generates a red fluorescent product (ex. 571 nm/em. 585 nm). |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TC0025 |
Testosterone acetate
NSC523836,NSC-523836,NSC 523836,醋酸睾酮 |
Others | Others |
Testosterone acetate (NSC-523836) 是一种 Testosterone 前药,是一种天然存在的雄激素睾酮酯。它可用于阳痿、虚弱、疲劳和性腺机能减退的研究。 | |||
T3130 |
Testosterone phenylpropionate
Testosterone hydrocinnamate,苯丙酸睾酮,Retandrol,Testosterone 17-phenylpropionate |
Others | Others |
Testosterone phenylpropionate (Testosterone 17-phenylpropionate) 是一种长效雄激素。d3-Testosterone phenylpropionate 可用作内标物。 | |||
T0419 |
Testosterone propionate
|
Others; Androgen Receptor; Transferase | Endocrinology/Hormones; Metabolism; Others |
Testosterone Propionate is a short acting oil-based injectable formulation of testosterone. Testosterone inhibits gonadotropin secretion from the pituitary gland and ablates estrogen production in the ovaries, thereby decreasing endogenous estrogen levels. | |||
TC0026 | Testosterone benzoate | Others | Others |
Testosterone benzoate 是一种合成的注射合成代谢雄激素类固醇 (AAS) 和一种雄激素酯。 | |||
T7727 |
Se-Methylselenocysteine
Se MSC,SeMCys,MSeC,L-硒甲基硒代半胱氨酸,Se-MSC,SeMSC |
BCL; IAP; Caspase | Apoptosis; Proteases/Proteasome |
Se-Methylselenocysteine (Se-MSC) 是具有口服活性的甲基硒前体,具有强大的抗氧化活性和抗癌活性。Se-Methylselenocysteine 可诱导细胞凋亡。 | |||
T4916 |
D-Glucaric acid potassium
D-Saccharic acid potassium salt,Glucosaccharic acid,D-葡萄糖二酸单钾盐,Glucaric Acid |
Others; Endogenous Metabolite | Metabolism; Others |
D-Glucaric acid potassium (D-Saccharic acid potassium salt) 是内源性代谢产物的一种。 | |||
T4744 |
5-HYDROXYINDOLE-3-ACETIC ACID
5-羟基吲哚-3-乙酸,5-HIAA |
Others; Endogenous Metabolite | Metabolism; Others |
5-Hydroxyindole-3-acetic acid (5-HIAA) 是 甲氧基肾上腺素或5-羟色胺的主要代谢产物,被用作神经内分泌肿瘤的生物标志物。它是血清素的分解产物,能够从尿液中排出。 | |||
T5S0581 |
Sec-O-Glucosylhamaudol
亥茅酚苷,Hamaudol 3-glucoside |
Others; Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience; Others |
Sec-O-Glucosylhamaudol (Hamaudol 3-glucoside) 是从滨海前胡中分离得到的一种天然产物,能够降低 μ 阿片受体的蛋白水平,可用于缓解疼痛的研究。它通过调节脂多糖刺激的 RAW264.7 细胞系中的 p38 丝裂原活化蛋白激酶具有抗炎作用。 | |||
T5S1889 |
Yunaconitine
Guayewuanine B,滇乌头碱 |
Others | Others |
Yunaconitine (Guayewuanine B) 是一种乌头类生物碱,具有剧毒。 | |||
T4956 |
Tetrahydroxystilbene-2-O-β-D-glucoside
tetrahydroxyl diphenylethylene-2-o-gluco,何首乌苷,EH-201 |
Others | Others |
Tetrahydroxystilbene-2-O-β-D-glucoside (EH-201) 是一种低分子量的促红细胞生成素诱导剂。 | |||
T4918 |
DL-Glyceraldehyde
Glyceric aldehyde,DL-甘油醛晶体 |
Reductase | Endocrinology/Hormones; Metabolism |
DL-Glyceraldehyde (Glyceric aldehyde) 是由酶甘油醛脱氢酶的作用产生的,该酶使用 NADP 作为辅因子将甘油转化为甘油醛。它是一种高活性化合物,可以修饰和交联蛋白质。 | |||
T4825 |
D-(+)-Xylose
D(+)-Xylose,木糖,(+)-Xylose,Wood sugar |
Endogenous Metabolite | Metabolism |
D-(+)-Xylose (Wood sugar) 是一种是一种戊醛糖,其化学式为C5H10O5,甜度为蔗糖的40%。木糖也存在于结缔组织的粘多糖中,有时也存在于尿液中。 | |||
T35749 |
Thymohydroquinone
Thymoquinol |
Antioxidant; Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction |
Thymohydroquinone (Thymoquinol) 是中药材百里香、牛至和其他唇形科植物中含有的单萜酚类化合物。 Thymohydroquinone 抑制癌细胞生长、减少氧化应激和调节炎症反应,在无细胞实验中清除2,2-二苯基-1-picrylhydrazyl 自由基(IC50 = 2.4 μg/ml),在浓度为1.6至6.4 μg/ml 的氧自由基吸收能力(ORAC)实验中,它的Trolox 当量值为2.6胸腺对苯二酚对A2780、OVCAR-8和CIS-A2780卵巢癌细胞(IC50分别为3.1、8.9和9.8 μM)和人卵巢永生化上皮细胞(IC50 = 14 μM)的生长有抑制作用,体外对恶性疟原虫也有抑制作用(IC50 = 15.9 μM)。 | |||
TN6038 |
1,2-Methylenedioxy-3,10,11-trimethoxynoraporphine
|
||
1,2-Methylenedioxy-3,10,11-trimethoxyaporphine exerts moderate vessel-relaxing activities with the IC 50 value from 16.50 to 32.81 microM at the test concentrations. | |||
T16160 |
Musk tibetene
Musk tibetine |
Others | Others |
Musk tibetine reveals no genotoxicity in the micronucleus test with human lymphocytes and human hepatoma cell lines. Musk tibetene is a nitro musk compound with carcinogenic activity. | |||
TN2760 | 2-Hydroxy-1,8-cineole | Antifection | Microbiology/Virology |
1. 2-endo-Hydroxy-1,8-cineole shows antimicrobial and bactericidal activities against against test bacteria (Staphylococcus aureus, Escherichia coli, and Pseudomonas fluorescens) .<BR/> | |||
TN3392 | Alpha-Toxicarol | Others | Others |
Alpha-Toxicarol exhibits a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. | |||
TN4219 |
Homobaldrinal
|
Others | Others |
Homobaldrinal has low toxic activity. It has genotoxic activity in the Salmonella/microsome test and the SOS-chromotest. | |||
TN4406 |
Lamiide
|
||
Lamiide has anti-inflammatory activity in carrageenin-induced paw edema test. It shows lipid peroxidation inhibition on rat-brain phospholipid peroxidation. | |||
TN3608 |
Catalpin
|
Others | Others |
Catalpin exhibited mutagenic activity towards Salmonella typhimurium strain TA100 in the presence and absence of rat liver homogenate (S9) mix in Ames' test. | |||
TN2047 | Pendulone | Antifection | Microbiology/Virology |
Pendulone could be a valuable chemopreventive agent, it shows strong inhibition on the effect of the cell cycle induced by TPA and shows potent anti-tumor-promoting activity for an in vivo two-stage carcinogenesis test. | |||
TN4380 | Karavilagenin D | Others | Others |
Karavilagenin D exhibits inhibitory effects on skin-tumor promotion in an in vivo two-stage mouse skin carcinogenesis test based on 7,12-dimethylbenz[a]anthracene (DMBA) as initiator, and with TPA as a promoter. It exhibits inhibition effect against human | |||
TN4241 | Hyptadienic acid | ||
Hyptadienic acid exhibits moderate cytotoxicity against HepG2 cells.It also shows a marked anti-inflammatory effect, it also exhibits strong antitumor-promoting activity in an in vivo two-stage carcinogenesis test of mouse tumor by using 7,12-dimethylbenz | |||
TN5880 |
Mesuol
|
||
Mesuol has antioxidant activity, it shows very high scavenging activity against DPPH radical; it also has immunomodulatory activity, can potentiate percentage neutrophil adhesion in neutrophil adhesion test in rats and phagocytosis in carbon clearance assay. Mesuol can suppress HIV-1 replication in Jurkat T cells, it inhibits TNFα-induced HIV-1-LTR transcriptional activity by targeting the nuclear factor-κB (NF-κB) pathway. | |||
T82248 |
Gymnoside I
|
||
Gymnoside I(化合物1)是糖苷氧基苄基2-异丁基苹果酸,其在小鼠被动皮肤过敏反应(PCA)实验中展现出抗过敏效能。该化合物有望在哮喘、神经衰弱和慢性肝炎治疗研究中应用。 | |||
TN4140 |
Glochidiol
|
Others | Others |
Glochidiol exhibits strong inhibitory effects against all three human tumor cell lines (MCF-7, NCI-H-460 and SF-268), it exerts its antiproliferative activity through the involvement of apoptosis. It exhibits a strong inhibitory effect on mouse skin tumor |