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74

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T40293	GPS491	Antiviral; HIV Protease	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	GPS491 具有抗病毒活性，通过改变 RNA 加工来抑制 HIV-1、腺病毒和冠状病毒复制。
T21230	Butyl decanoate Butyl caprate,AI3-33573,Decanoic acid, butyl ester
	Butyl decanoate could substitute hazardous compounds used in tissue processing and dewaxing, along with other compounds without impairing the diagnostic value of the tissue sections. It is also used as an internal standard to calculate the acid concentrat
T77700	2-Butyl-1,2-benzisothiazolin-3-one 2-butylbenzo[d]isothiazol-3(2H)-one	Antifungal	Microbiology/Virology
	2-Butyl-1,2-benzisothiazolin-3-one 是一种可口服的抗菌剂，具有抗菌活性，常见于制药专业和食品加工。
T6274	RO4929097 RG-4733	Beta Amyloid; Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	RO4929097 (RG-4733) 是 γ secretase 抑制剂，IC50=4 nM，能够抑制细胞内 Aβ40 (EC50:14 nM) 的产生和 Notch (EC50:5 nM) 活性。
T8828	CP 424174	IL Receptor	Immunology/Inflammation
	CP 424174 是一种具有可逆性的 IL-1β抑制剂(IC50:210 nM)，也能够间接性抑制 NLRP3。
T16991	Targapremir-210 TGP-210	Apoptosis	Apoptosis
	Targapremir-210 (TGP-210) 是一种具有选择性和有效性的 miR-210 (miRNA-210) 抑制剂，抑制 pre-miR-210 的加工，可诱导乳腺癌细胞凋亡。
T14935	Elexacaftor VX-445	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	Elexacaftor (VX-445) 是一种囊性纤维化跨膜电导调节因子 (CFTR) 校正剂。它促进CFTR 的加工和转运，增加细胞表面CFTR 的数量。
T22438	Tetramethylthiuram monosulfide 一硫化四甲基秋兰姆,TMTM	Others	Others
	Tetramethylthiuram monosulfide 被广泛用作橡胶加工技术中的催化剂，它具有中等毒性，并在菌株 TA 100 和 TA 1535（鼠伤寒沙门氏菌 LT 2）中引起点突变。
T2522	Peramivir Trihydrate RWJ-270201,帕拉米韦三水合物,S-021812,BCX-1812,RWJ 270201 trihydrate,BCX 1812 trihydrate	Influenza Virus	Microbiology/Virology
	Peramivir Trihydrate (RWJ-270201) 是一种高效、选择性和口服有效的流感病毒神经氨酸酶(NA)抑制剂，对 9 个亚型 NA 抑制作用的IC50值为 0.9-4.3 nM。它是一种环戊烷衍生物，具有抗甲型和乙型流感病毒的活性。
T2702	IWP-2 IWP2	Casein Kinase; Wnt/beta-catenin; Porcupine	Cytoskeletal Signaling; Metabolism; Stem Cells
	IWP-2 是一种 Wnt 加工和分泌抑制剂，IC50为 27 nM。它还是一种具有 ATP 竞争能力的CK1δ抑制剂，对于M82FCK1δ的IC50为 40 nM。在无细胞试验中，它可选择性阻断 Porcn 介导的 Wnt 棕榈酰化。
TP1828	N-Acetyl-Ser-Asp-Lys-Pro	RAAS	Endocrinology/Hormones
	N-Acetyl-Ser-Asp-Lys-Pro 通过酶促处理胸腺素 β4 在骨髓细胞中形成。它抑制多能造血干细胞进入细胞周期的 S 期，并防止小鼠中的 Ara-C 致死性。
T6271	Tipifarnib 替吡法尼,R115777,Zarnestra,IND 58359	Transferase	Metabolism
	Tipifarnib (IND 58359) 能够抑制法尼基转移酶 (FTase)，IC50=0.86 nM，具有潜在抗肿瘤特性。
TP1597L	Secretoneurin, rat acetate Secretoneurin, rat acetate(149146-12-3 Free base)	Others	Others
	Secretoneurin, rat acetate 是一种 33 个氨基酸的多肽，由分泌粒蛋白 II (SgII) 的蛋白水解加工产生。它在体内和体外诱导大鼠纹状体中的多巴胺释放，它对单核细胞和嗜酸性粒细胞有很强的趋化作用，但对粒细胞没有。
T3701	MCC950 CP-456773	NOD	Immunology/Inflammation; NF-κB
	MCC950 (CP-456773) 是NLRP3的选择性抑制剂，能够作用于BMDMs(IC50:7.5 nM) 和 HMDMs(IC50:8.1 nM)。
TP1786L	Amyloid β-Protein 10-20 acetate Amyloid β-Protein 10-20 acetate(152286-31-2 free base)	Beta Amyloid	Neuroscience
	Amyloid β-Protein 10-20 acetate (Amyloid β-Protein 10-20 acetate (152286-31-2 free base)) 是 Amyloid-β 肽的片段，可能用于神经系统疾病的研究。Amyloid β 蛋白片段含有 α-分泌酶加工位点（Lys16-Leu17 键）。它还包含负责与小胶质细胞结合的 HHQK 结构域（残基 13-16）。
T3226	Paritaprevir ABT-450,Veruprevir,帕利瑞韦	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Paritaprevir (ABT-450) 是一种口服生物可利用的合成酰基磺酰胺抑制剂，可抑制丙型肝炎病毒 (HCV) 蛋白酶复合物，由非结构蛋白 3 和 4A (NS3/NS4A) 组成，对 HCV 基因型 1 具有潜在活性。给药后，paritaprevir 可逆地结合 HCV NS3/NS4A 蛋白酶的活性中心和结合位点，并阻止 NS3/NS4A 蛋白酶介导的多蛋白成熟。这会破坏病毒蛋白的加工和病毒复制复合物的形成，从而抑制病毒在 HCV 基因型 1 感染的宿主细胞中的复制。 NS3 是一种丝氨酸蛋白酶，对于 HCV 多蛋白内多个位点的蛋白水解切割至关重要，并且在 HCV 核糖核酸 (RNA) 复制过程中起关键作用。 NS4A 是 NS3 的激活因子。 HCV 是属于黄病毒科的一种小的、有包膜的单链 RNA 病毒，感染与肝细胞癌 (HCC) 的发展有关。
T11397	GGTI298	Others	Others
	GGTI298 is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor, strongly inhibiting the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras, with IC50 values of 3 and > 20 μM in vivo, respectively.
T13085	Targaprimir-96	Others	Others
	Targaprimir-96 is a potent microRNA-96 (miR-96) processing inhibitor.
T41178	SSM 3 trifluoroacetate
	SSM 3 trifluoroacetate is a potent furin inhibitor (EC50= 54 nM). Blocks furin-dependent cell surface processing of anthrax protective antigen-83in vitro.
T26446	A 77003 A-77003,Abbott 77003,A77003
	A 77003 is a HIV-1 protease inhibitor. A77003 impairs HIV-1 protease-mediated Gag processing.
TQ0030	Tomeglovir 托美洛韦,BAY 38-4766	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Tomeglovir is a potent anti-CMV agent, inhibiting the processing of viral DNA-concatemers (IC50s: 0.34/0.039 μM for HCMV and MCMV).
T24210	JNJ-40418677
	JNJ-40418677 is a γ-secretase modulator that selectively blocks γ-site cleavage of the APP without affecting the processing of Notch.
T68268	OSL-95II
	OSL-95II is an inhibitor of the glycan-processing enzyme endoplasmic-reticular glucosidase.
T24756	SAMT-247 SAMT 247
	SAMT-247 is an HIV inhibitor that acts by modifying the nucleocapsid NCp7 region of Gag in infected cells and blocking Gag processing and reducing infectivity.
T39324	2,3-Dimethyl-2,3-diphenylbutane
	2,3-Dimethyl-2,3-diphenylbutane is a byproduct of the decomposition of Dicumylperoxide (DCP). It serves as an initiator for Diallyl orthophthalate (DAOP), a reactive plasticizer that is used to enhance the processing of polyphenylene oxide (PPO) in manufacturing.
T13085L	Targaprimir-96 TFA (1655508-14-7 free base) Targaprimir-96 TFA	Others	Others
	Targaprimir-96 TFA is a potent microRNA-96 (miR-96) processing inhibitor.
T39526	Decanoyl-RVKR-CMK TFA DecRVKRcmk TFA,Decanoyl-RVKR-CMK TFA
	Decanoyl-RVKR-CMK (DecRVKRcmk) TFA effectively hinders the processing of over-expressed gp160 and suppresses HIV-1 replication.
T68339	SSM3 TFA
	SSM3 TFA is a potent furin inhibitor, blocking furin-dependent cell surface processing of anthrax protective antigen-83 in vitro..
T69716	Solimastat
	Solimastat is a novel oral, broad-spectrum matrix metalloproteinase inhibitor (MMPI), being >10-fold more active than marimastat in inhibiting the processing of cell-bound TNF-alpha.
T35433	α-hydroxy Farnesyl Phosphonic Acid
	α-hydroxy Farnesyl phosphonic acid is a nonhydrolyzable analog of farnesyl pyrophosphate which acts as a competitive inhibitor of farnesyl transferase (FTase). At concentrations greater than 1 μM, α-hydroxy farnesyl phosphonic acid inhibits the processing of Ras in Ha-ras-transformed NIH3T3 cells.
T69640	MI-1851
	MI-1851 is a potent peptidomimetic inhibitor. MI-1851could prevent proteolytic processing of the S protein from SARSCoV-2 by endogenous furin in HEK293 cells.
T15353	FTI-2153	Others	Others
	FTI-2153 is a potent and highly selective farnesyltransferase (FTase) inhibitor (IC50: 1.4 nM). FTI-2153 is >3000-fold more potent at blocking H-Ras (IC50, 10 nM) than Rap1A processing.
TP1597	Secretoneurin, rat
	Secretoneurin, rat, a 33-amino acid polypeptide, is generated by proteolytic processing of secretogranin II (SgII).
TP2038	Decanoyl-RVKR-CMK
	Subtilisin/Kex2p-like proprotein convertase inhibitor; blocks activity of all seven convertases (PC1, PC2, PC4, PACE4, PC5, PC7 and furin). Abolishes proET-1 processing in endothelial cells; inhibits regulated secretion of the neuronal polypeptide VGF in
TP1306	GLP-1(7-37)
	GLP-1 (7-37) is a truncated, bioactive form of GLP-1 that is the product of proglucagon processing in intestinal endocrine L cells.
TP2107	TAPI 0
	ADAM-17 (TACE) and MMP inhibitor; attenuates TNF-α processing. Acts in concert with GM6001 to inhibit Chlamydia trachomatis growth.
T69111	2',3'-Dialdehyde ATP
	2',3'-Dialdehyde ATP is a derivative of, and the oxidized form of, ATP. It has been found to be a specific, irreversible inhibitor of component A3 of the methylreductase system which plays a role in processing amino acids.
TP1258	Somatostatin-28 (1-12) 1-12-Somatostatin-28,Somatostatin-28 1-12
	Somatostatin-28 (1-12) is a somatostatin fragment which is monitored in brain tissue to track processing of somatostatin.
T35080	VU0456940 VU-0456940,VU 0456940
	VU0456940 is a potent M1 PAM with excellent selectivity (hM1 EC50 = 340 nM, 14-fold leftward shift of the ACh CRC; hM2–hM5 inactive). VU0456940 potentiated the excitation of a subthreshold concentration of CCh in MSNs. VU0456940 shifted APP processing and
T72013	Epigenetic Multiple Ligand
	Epigenetic Multiple Ligand is a cell-permeable inhibitor of substrate processing by several chromatin-associated enzymes, including SIRT1/2, H3/SET7, H3/p300/CBP, H4/RmtA, PABP1/CARM1, and H4/PRMT1. It acts by inducing either apoptosis or granulocytic differentiation.
TP2144	Globomycin	Others	Others
	Globomycin is a lipopeptide antibiotic and an inhibitor of signal peptidase II (LspA). It inhibits the processing of the prolipoprotein by binding irreversibly to the peptidase.
TP1147	Glucagon-like peptide 1 (1-37), human TFA HuGLP-1 TFA
	Glucagon-like peptide 1 (1-37), human (TFA) is a highly potent agonist of the GLP-1 receptor, it is a kind of pancreatic hormone synthesized by post-translational processing of proglucagon.
TP1341	Polymyxin B nonapeptide
	Polymyxin B nonapeptide, a cationic cyclic peptide derived by enzymatic processing from the naturally occurring peptide polymyxin B, is able to increase the permeability of the outer membrane of Gram-negative bacteria toward hydrophobic antibiotics probab
T38116	Fmoc-Ala-Glu-Asn-Lys-NH2 Fmoc-Ala-Glu-Asn-Lys-NH2
	Fmoc-Ala-Glu-Asn-Lys-NH2 is a peptide inhibitor that selectively targets asparagine endopeptidase (AEP) and inhibits the cleavage of amyloid precursor protein (APP). AEP, a pH-controlled cysteine proteinase, plays a crucial role in the proteolytic processing of APP, and its activity is enhanced during the aging process [1].
T41212	FTI 277
	FTI 277 is a prodrug form of FTI 276 that inhibits farnesyltransferase (FTase) (IC50 = 0.5 nM). Inhibits H-Ras and K-Ras processing in whole cells (IC50 values are 0.1 and 10μM respectively) and disrupts constitutive H-Ras-specific activation of MAPK. Causes significant antiproliferative effects in human malignant glioma cells and many other tumor cell lines.
TP2243	Dynorphin (2-17), amide, porcine	Others	Others
	Dynorphins are a class of opioid peptides that arise from the precursor protein prodynorphin. When prodynorphin is cleaved during processing by proprotein convertase 2 (PC2), multiple active peptides are released: dynorphin A, dynorphin B, and α/β-neo-end
T76665	Z-LEED-FMK
	Z-LEED-FMK 是 caspase-13和 caspase-4抑制剂。Z-LEED-FMK 还能抑制S. typhimurium 感染的巨噬细胞中caspase-1的加工。
TP1148	Glucagon-like peptide 1 (1-37), human HuGLP-1
	Glucagon-like peptide 1 (1-37), human is a highly potent agonist of the GLP-1 receptor.Pancreatic hormone synthesized by post-translational processing of proglucagon. Unlike truncated forms of GLP-1, it has no effect on food intake in rats and does not en
TP1786	β-Amyloid (10-20) Amyloid β-Protein 10-20
	Amyloid β-Protein (10-20) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.Amyloid β protein fragment containing the α-secretase processing site (Lys16-Leu17 bond). It also contains the HHQK domain (residues 13-16) re
TP1581	C-Type Natriuretic Peptide (1-53), human
	CNP, a member of the natriuretic peptide family, was first identified in porcine brain and later found in other mammals as well as non-mammals. Processing of the CNP precursor gives rise to CNP-22 and its N-terminally elongated form, CNP-53. The CNPs shar

化合物

Cat.No: T40293

Target: Antiviral, HIV Protease

Butyl decanoate

Cat.No: T21230

Synonym: Butyl caprate,AI3-33573,Decanoic acid, butyl ester

2-Butyl-1,2-benzisothiazolin-3-one

Cat.No: T77700

Synonym: 2-butylbenzo[d]isothiazol-3(2H)-one

Target: Antifungal

Cat.No: T6274

Synonym: RG-4733

Target: Beta Amyloid, Gamma-secretase

Cat.No: T8828

Target: IL Receptor

Targapremir-210

Cat.No: T16991

Synonym: TGP-210

Target: Apoptosis

Cat.No: T14935

Synonym: VX-445

Target: CFTR, Autophagy

Tetramethylthiuram monosulfide

Cat.No: T22438

Synonym: 一硫化四甲基秋兰姆,TMTM

Target: Others

Peramivir Trihydrate

Cat.No: T2522

Synonym: RWJ-270201,帕拉米韦三水合物,S-021812,BCX-1812,RWJ 270201 trihydrate,BCX 1812 trihydrate

Target: Influenza Virus

Cat.No: T2702

Synonym: IWP2

Target: Casein Kinase, Wnt/beta-catenin, Porcupine

N-Acetyl-Ser-Asp-Lys-Pro

Cat.No: TP1828

Target: RAAS

Cat.No: T6271

Synonym: 替吡法尼,R115777,Zarnestra,IND 58359

Target: Transferase

Secretoneurin, rat acetate

Cat.No: TP1597L

Synonym: Secretoneurin, rat acetate(149146-12-3 Free base)

Target: Others

Cat.No: T3701

Synonym: CP-456773

Target: NOD

Amyloid β-Protein 10-20 acetate

Cat.No: TP1786L

Synonym: Amyloid β-Protein 10-20 acetate(152286-31-2 free base)

Target: Beta Amyloid

Cat.No: T3226

Synonym: ABT-450,Veruprevir,帕利瑞韦

Target: HCV Protease

Cat.No: T11397

Target: Others

Cat.No: T13085

Target: Others

SSM 3 trifluoroacetate

Cat.No: T41178

Cat.No: T26446

Synonym: A-77003,Abbott 77003,A77003

Cat.No: TQ0030

Synonym: 托美洛韦,BAY 38-4766

Target: HCV Protease

Cat.No: T24210

Cat.No: T68268

Cat.No: T24756

Synonym: SAMT 247

2,3-Dimethyl-2,3-diphenylbutane

Cat.No: T39324

Targaprimir-96 TFA (1655508-14-7 free base)

Cat.No: T13085L

Synonym: Targaprimir-96 TFA

Target: Others

Decanoyl-RVKR-CMK TFA

Cat.No: T39526

Synonym: DecRVKRcmk TFA,Decanoyl-RVKR-CMK TFA

Cat.No: T68339

Cat.No: T69716

α-hydroxy Farnesyl Phosphonic Acid

Cat.No: T35433

Cat.No: T69640

Cat.No: T15353

Target: Others

Secretoneurin, rat

Cat.No: TP1597

Decanoyl-RVKR-CMK

Cat.No: TP2038

Cat.No: TP1306

Cat.No: TP2107

2',3'-Dialdehyde ATP

Cat.No: T69111

Somatostatin-28 (1-12)

Cat.No: TP1258

Synonym: 1-12-Somatostatin-28,Somatostatin-28 1-12

Cat.No: T35080

Synonym: VU-0456940,VU 0456940

Epigenetic Multiple Ligand

Cat.No: T72013

Cat.No: TP2144

Target: Others

Glucagon-like peptide 1 (1-37), human TFA

Cat.No: TP1147

Synonym: HuGLP-1 TFA

Polymyxin B nonapeptide

Cat.No: TP1341

Fmoc-Ala-Glu-Asn-Lys-NH2

Cat.No: T38116

Synonym: Fmoc-Ala-Glu-Asn-Lys-NH2

Cat.No: T41212

Dynorphin (2-17), amide, porcine

Cat.No: TP2243

Target: Others

Cat.No: T76665

Glucagon-like peptide 1 (1-37), human

Cat.No: TP1148

Synonym: HuGLP-1

β-Amyloid (10-20)

Cat.No: TP1786

Synonym: Amyloid β-Protein 10-20

C-Type Natriuretic Peptide (1-53), human

Cat.No: TP1581

Cat. No.	Product Name	Target	Signaling Pathways
T16674	Pseudouridine	Endogenous Metabolite	Metabolism
	Pseudouridine 是非编码 RNA 中丰富的修饰核苷，通过稳定 RNA 结构增强核糖体 RNA 和的转移 RNA 功能。
TMS2181	trans-Zeatin (E)-Zeatin,玉米素	ERK; MEK; Endogenous Metabolite	MAPK; Metabolism
	trans-Zeatin ((E)-Zeatin) 是植物细胞分裂素，可抑制紫外线诱导的MEK/ERK 的活化，在细胞生长、分化和分裂中起着重要的作用。
T13815	Penicillic acid	Apoptosis; Caspase; Antibacterial; Antibiotic	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Penicillic acid，一种由多种Aspergillus和Penicillium物种合成的polyketide mycotoxin，通过阻碍caspase-8的自我处理作用，抑制Fas ligand引发的apoptosis。此外，体外研究表明，Penicillic acid在rat alveolar macrophages中显示出cytotoxic特性。
TN4171	Grossamide	NO Synthase	Immunology/Inflammation
	Grossamide (GSE) 是一种来自虎杖的木脂酰胺。Grossamide 具有抗炎症活性，可通过上调精氨酸酶和下调诱导型一氧化氮合酶来抑制精氨酸产生一氧化氮(NO)，抑制NO对OXPHOS的抑制作用。
T4S1499	Ginsenoside Rk1 人参皂苷RK1,人参皂苷	Apoptosis; Others; NF-κB; PI3K; JAK	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; NF-κB; Others; PI3K/Akt/mTOR signaling; Stem Cells
	Ginsenoside Rk1 是人参的高温加工提取物，抑制Jak2/Stat3信号通路和NF-κB 的激活。它具有抗肿瘤、抗血小板聚集活性、抗炎、抗胰岛素抵抗、肾保护和抗菌作用，可使认知功能增强，脂质积聚减少和预防骨质疏松症，还诱导细胞凋亡。
T72581	SARS-CoV MPro-IN-2
	SARS-CoVMPro-IN-2 是一种有效的SARS-CoV-2 Mpro 抑制剂，IC50sub>值为 72.07 nM。病毒的主要蛋白酶 Mpro 作为加工病毒多蛋白的主要酶，有助于 SARS-CoV-2 在宿主细胞中的复制和转录，并已被定性为药物发现的有吸引力的靶点。SARS-CoVMPro-IN-2 具有研究 COVID-19 的潜力。

天然产物

Cat.No: T16674

Target: Endogenous Metabolite

Cat.No: TMS2181

Synonym: (E)-Zeatin,玉米素

Target: ERK, MEK, Endogenous Metabolite

Penicillic acid

Cat.No: T13815

Target: Apoptosis, Caspase, Antibacterial, Antibiotic

Cat.No: TN4171

Target: NO Synthase

Ginsenoside Rk1

Cat.No: T4S1499

Synonym: 人参皂苷RK1,人参皂苷

Target: Apoptosis, Others, NF-κB, PI3K, JAK

SARS-CoV MPro-IN-2

Cat.No: T72581

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