store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Targapremir-210 (TGP-210) 是一种具有选择性和有效性的 miR-210 (miRNA-210) 抑制剂,抑制 pre-miR-210 的加工,可诱导乳腺癌细胞凋亡。
产品描述 | Targapremir-210 (TGP-210) is a selective and potent miRNA-210 (miRNA-210) inhibitor that inhibits pre-miR-210 processing and induces apoptosis in breast cancer cells. |
靶点活性 | miR-210:200 nM |
体外活性 |
Targapremir-210 decreases mature miR-210 levels in MDA-MB-231 cells cultured under hypoxic conditions, with an IC50 of ∼200 nM[1]. Targapremir-210 (200 nM) induces MDA-MB-231 cells apoptosis is selective for the hypoxic environment. Targapremir-210 induces cells apoptosis under hypoxic conditions and does not induce apoptosis in MDA-MB-231 cells cultured in normoxia[1]. |
体内活性 | In vivo, a single intraperitoneal injection of Targapremir-210 (100 μL of 200 nM) impedes the proliferation of MDA-MB-231 triple-negative breast cancer (TNBC) cells. Targapremir-210 successfully reaches the tumor and sustains its presence throughout the entire 21-day period, leading to a reduction in tumor burden in a TNBC mouse model[1]. |
别名 | TGP-210 |
分子量 | 592.69 |
分子式 | C32H36N10O2 |
CAS No. | 1049722-30-6 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (168.72 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.6872 mL | 8.4361 mL | 16.8722 mL | 42.1806 mL |
5 mM | 0.3374 mL | 1.6872 mL | 3.3744 mL | 8.4361 mL | |
10 mM | 0.1687 mL | 0.8436 mL | 1.6872 mL | 4.2181 mL | |
20 mM | 0.0844 mL | 0.4218 mL | 0.8436 mL | 2.109 mL | |
50 mM | 0.0337 mL | 0.1687 mL | 0.3374 mL | 0.8436 mL | |
100 mM | 0.0169 mL | 0.0844 mL | 0.1687 mL | 0.4218 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
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