keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Globomycin is a lipopeptide antibiotic and an inhibitor of signal peptidase II (LspA). It inhibits the processing of the prolipoprotein by binding irreversibly to the peptidase.
产品描述 | Globomycin is a lipopeptide antibiotic and an inhibitor of signal peptidase II (LspA). It inhibits the processing of the prolipoprotein by binding irreversibly to the peptidase. |
体外活性 | Globomycin is capable of inhibiting the growth of S. melliferum. The MICs are 12.5 μM for strain B88 and 6.25 μM for strain BC3. Globomycin can interfere with the processing of bacterial lipoproteins by inhibition of signal peptidase II in gracilicutes (Gram-negative eubacteria) and firmicutes (Gram-positive eubacteria) [1]. In B. diminuta DS010 cells, in the Globomycin-treated cultures, most of the organophosphate hydrolase (OPH) accumulates in the cytoplasmic fraction in an unprocessed form. This is in contrast with the untreated cells where very little precursor was detectable. Moreover, there is substantially less mature OPH detectable in the membrane fraction following Globomycin treatment [2]. |
分子量 | 655.834 |
分子式 | C32H57N5O9 |
CAS No. | 67076-74-8 |
keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Globomycin 67076-74-8 Others Inhibitor inhibitor inhibit