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Search Results for " insulin secretion "

99

抑制剂 & 化合物

15

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8348	Phentolamine	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Phentolamine 是一种 alpha-1 和 alpha-2 选择性肾上腺素能受体拮抗剂。
T7127	DC260126	Apoptosis; GPR	Apoptosis; Endocrinology/Hormones; GPCR/G Protein
	DC260126 是一种 GPR40 (FFAR1)拮抗剂，对棕榈酸酯诱导的内质网应激和凋亡有保护作用。它剂量依赖性地抑制亚油酸、油酸、棕榈油酸和月桂酸刺激的 GPR40 介导的 Ca2+升高，IC50分别 6.28、5.96、7.07和4.58 μM。
T21623	AS1269574 AS 1269574	GPR; TRP/TRPV Channel	Endocrinology/Hormones; GPCR/G Protein; Membrane transporter/Ion channel
	AS1269574 是口服有效的GPR119激动剂，在表达人 GPR119 的 HEK293 细胞中EC50为 2.5 μM。它激活 TRPA1 阳离子通道，刺激胰高血糖素样肽-1分泌。它仅在高糖条件下特异性诱导胰腺 β 细胞分泌葡萄糖依赖性胰岛素。它在 2 型糖尿病的研究中具有价值。
T40187	GNF2133	DYRK	Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors
	GNF2133 是一种有效的特异性 DYRK1A 抑制剂，IC50 为 6.2 nM。 GNF2133 可用于关于 1 型糖尿病的研究。
T3171	GSK137647A GSK 137647	GPR	Endocrinology/Hormones; GPCR/G Protein
	GSK137647A (GSK 137647) 是一种选择性FFA4激动剂，作用于人类和大小鼠FFA4的pEC50分别为6.3、6.1和6.2。
T15247	ESI-05 NSC 116966	cAMP	GPCR/G Protein
	ESI-05 (NSC-116966) 是特异性的 cAMP 直接激活交换蛋白 2 (EPAC2) 拮抗剂(IC50:0.4 µM)，能够抑制 cAMP 诱导的 EPAC2 的活化，并 EAPC2 介导的 Rap1 的活化。
TP1376	GLP-1(7-37) acetate(106612-94-6 free base) GLP-1(7-37) acetate	Others; Glucagon Receptor	GPCR/G Protein; Others
	GLP-1(7-37) acetate 是肠道胰岛素激素，能够促进葡萄糖诱导的胰岛素分泌。
TP1382L	HAEGTFTSDVS acetate HAEGTFTSDVS acetate(864915-61-7 free base)	Glucagon Receptor	GPCR/G Protein
	HAEGTFTSDVS acetate 是 GLP-1 的一个 N 末端 1-11 残基，GLP-1 可刺激胰腺 β 细胞分泌胰岛素。
TP2017L	GIP (1-39) acetate GIP (1-39) acetate(725474-97-5 Free base)	Others	Others
	GIP (1-39) acetate 是一种从猪肠道中纯化的胃抑制肽 (GIP)，可刺激胰岛素分泌。
TP1863L	Glucagon (19-29), human acetate	Glucagon Receptor	GPCR/G Protein
	Glucagon (19-29), human acetate 是一种从胰高血糖素加工而来的 COOH 末端片段，是一种有效的胰岛素分泌抑制剂。
TP2018L	GIP (human) acetate GIP (human) acetate(100040-31-1 Free base)	IGF-1R	Tyrosine Kinase/Adaptors
	GIP (human) acetate 是葡萄糖依赖性胰岛素分泌的刺激剂和胃酸分泌的弱抑制剂。 GIP (human) acetate 在脂质代谢和肥胖的发展中起着至关重要的作用。
T31976	Glymidine sodium	Others	Others
	Glymidine sodium 是口服有活性的抗糖尿病药物，也是肝脂肪分解的抑制剂。它通过抑制葡萄糖的形成，也对由于内源性脂质动员抑制而导致的丙酮酸氧化升高具有抑制作用。
T1088	Repaglinide AG-EE 388 ZW,AG-EE 623ZW,瑞格列奈	Potassium Channel; PPAR	DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism
	Repaglinide (AG-EE 623ZW) 是一种能够用于2 型糖尿病的胰岛素促分泌剂。
T1781	GW9508 GW 9508	GPR; Potassium Channel	Endocrinology/Hormones; GPCR/G Protein; Membrane transporter/Ion channel
	GW 9508 是一种选择性 G 蛋白偶联受体FFA1(GPR40) 和GPR120激动剂。它是一种葡萄糖敏感性胰岛素促分泌剂和 ATP 敏感性钾通道开放剂，具有抗炎和抗动脉粥样硬化活性。
T6587	Mitiglinide Calcium KAD-1229,米格列奈钙,S21403,米格列奈	ATPase; Potassium Channel	Membrane transporter/Ion channel
	Mitiglinide Calcium (KAD-1229) 是一种 ATP 敏感的 K+通道拮抗剂，具有促胰岛素的作用。Mitiglinide Calcium 对 Kir6.2/SUR1 复合物 (胰腺-细胞 KATP 通道) 具有高度特异性。Mitiglinide Calcium 在 2 型糖尿病的研究中具有价值。
T37588L	GIP (1-30) amide, porcine acetate	IGF-1R	Tyrosine Kinase/Adaptors
	GIP (1-30) amide, porcine acetate 是完全葡萄糖依赖性促胰岛素多肽 (GIP) 受体的激动剂。它可弱抑制胃酸分泌，强烈刺激胰岛素。
T6646	Rosiglitazone hydrochloride 盐酸罗格列酮,BRL-49653 HCl,Rosiglitazone HCl	Ferroptosis; TRP/TRPV Channel; PPAR; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism
	Rosiglitazone hydrochloride (BRL-49653 HCl) 是一种降血糖药物，通过与脂肪细胞中的 PPAR 受体结合来刺激胰岛素分泌。它对 PPARγ1、PPARγ2 和 PPARγ 的EC50值分别为 30 nM、100 nM 和 60 nM。它也是TRPC5的激活剂和TRPM3的抑制剂。
T17177	TUG-424 TUG424	Others	Others
	TUG-424 是一种有效且选择性的游离脂肪酸受体 1 (FFA1/GPR40) 激动剂，EC50 为 32 nM。TUG-424 在 100 nM 处显著增加葡萄糖刺激的胰岛素分泌。TUG-424 可能有助于探索 FFA1 在糖尿病或肥胖等代谢性疾病中的作用。
T13867	RH01386	Others	Others
	RH01386是可以预防 ER 应激诱导的β细胞功能障碍和死亡、抑制促凋亡基因表达的小分子。它恢复内质网应激受损的葡萄糖刺激的胰岛素分泌反应。对2型糖尿病具有潜在的研究价值。
T1674	Nateglinide 那格列奈,A4166,Senaglinide	Potassium Channel; Proteasome; PPAR	DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Proteases/Proteasome; Ubiquitination
	Nateglinide (Senaglinide) 是 D-苯丙氨酸的一种衍生物，是口服有效的、短效促胰岛素释放化合物，也是 DPP IV 抑制剂。 Nateglinide 抑制胰岛 β 细胞中 ATP 敏感的 K+通道。Nateglinide 在 2 型糖尿病中具有研究价值。
T78097L	Mazdutide acetate（2259884-03-0 free base） Mazdutide acetate（2259884-03-0 free base）,OXM-3 acetate,LY-3305677 acetate,IBI-362 acetate	Glucagon Receptor	GPCR/G Protein
	Mazdutide acetate 是一种高效的胰高血糖素样肽 (GLP-1R) 与胰高血糖素受体 (GCGR) 的共激动剂，是一种胃泌酸调节素类似物。Mazdutide acetate可刺激小鼠胰岛的胰岛素分泌，可用于研究肥胖和 2 型糖尿病 (T2D) 。
T1530	Mitiglinide calcium hydrate KAD-1229 calcium hydrate,米格列奈钙,Mitiglinide calcium,S-21403 calcium hydrate	Potassium Channel	Membrane transporter/Ion channel
	Mitiglinide calcium hydrate (S-21403 calcium hydrate) 是一种 ATP 敏感的 K+通道 (KATPchannel) 拮抗剂，属于促胰岛素化合物。它对 Kir6.2/SUR1 复合物 (胰腺-细胞 KATP 通道) 具有高度特异性，在 2 型糖尿病中有研究价值。
T15368L	Galantide acetate Galantide acetate(138579-66-5 Free base)	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	Galantide acetate 是一种特殊的甘丙肽受体 (galanin receptor) 拮抗剂，是一种由甘丙肽和 P 物质片段组成的肽段，在大鼠下丘脑可识别两类甘丙肽结合位点 (KD 分别小于 0.1 nM 和 ~6 nM)。Galantide 剂量依赖性 (IC50=1.0 nM) 拮抗甘丙肽介导的葡萄糖诱导的小鼠胰岛胰岛素分泌抑制。Galantide acetate 似乎与单一的 SP 受体群结合 (KD~40 nM)。
T34470	S 9871 RX-801080,RX 801080,S9871,RX801080,S-9871
	S 9871, also known as RX 801080, is an imidazoline derivative reported to antagonize imidazoline-stimulated insulin secretion.
TP1141	GLP-1(7-36), amide acetate GLP-1(7-36) Acetate,Human GLP-1-(7-36)-amide Acetate
	GLP-1(7-36) Acetate is a major intestinal hormone that stimulates glucose-induced insulin secretion from β cells.
T25739	Linogliride McN-3935,McN3935,McN 3935,Linogliridum,Linoglirida
	Linogliride 是一种基于胍的胰岛素分泌抑制剂，也是 pirogliride 的结构类似物，具有降血糖活性。它可以阻断胰腺β细胞膜上对 ATP 敏感的钾通道，从而刺激胰岛素分泌并改善葡萄糖耐受性。
TP2258	HNGF6A	Others	Others
	increases glucose stimulated insulin secretion and glucose metabolism
T70373	AS2575959
	AS2575959 is a novel GPR40 agonist, exhibiting glucose metabolism improvement and synergistic effect with sitagliptin on insulin and incretin secretion.
T70113	ATM-1001
	ATM-1001 is an inhibitor of the cancer-associated tropomyosin 3.1 (Tpm3.1), suppressing glucose-stimulated insulin secretion (GSIS) from the pancreatic islets.
T37892	GLP-1(7-36), amide TFA
	GLP-1(7-36), amide TFA is a prominent intestinal hormone known to stimulate glucose-induced insulin secretion from β cells[1].
TP1584	GIP (1-30) amide,human GIP (1-30) amide (Human)
	GIP (1-30) amide (Human) is an insulin-dependent glucose-dependent polypeptide.The sugar-dependent insulin polypeptide (GIP) is an insulin secreting hormone, which can stimulate the secretion of insulin and reduce the occurrence of postpranal-glycemic dis
TP2209	Xenin-8	Others	Others
	neurotensin-like peptide that modulate pancreatic insulin and glucagon secretion/effects
T24620	PF-06372222 PF-0637222,PF0637222,PF 0637222
	PF-06372222 is a small-molecule negative allosteric modulator of the glucagon receptor (GCGR). PF-06372222 is also an antagonist for glucagon-like peptide-1 receptor GLP-1R, which inhibits glucagon secretion and glucose-dependent insulin secretion.
T40518	C-Peptide 2, rat
	C-Peptide 2, rat, a 31-amino-acid peptide, serves as a constituent in proinsulin. It possesses the ability to hinder glucose-triggered insulin secretion.
T27938	LY2922083 LY 2922083,LY-2922083
	LY2922083 is a Potent and Selective GPR40 agonist. LY2922083 demonstrates potent, efficacious and durable dose dependent reductions in glucose levels along with significant increases in insulin and GLP-1 secretion.
T25739L	Linogliride fumarate McN 3935,McN-3935,McN3935
	Linogliride fumarate 是Linogliride 的富马酸盐。Linogliride 是一种基于胍的胰岛素分泌抑制剂，也是pirogliride 的结构类似物，具有降血糖活性。它可以阻断胰腺β细胞膜上对ATP 敏感的钾通道，从而刺激胰岛素分泌并改善葡萄糖耐受性。
T62836	Hit 1
	Hit 1 是一种胰岛素降解酶 (IDE) 的激活剂 (EC50: 5.5 μM)，能够降低刺激葡萄糖的胰岛素分泌。
T69477	F81-1144b
	F81-1144b is a matrix metalloproteinase inhibitor which reduces secretion of very low density lipoprotein-triacylglycerol, thereby lowering TAG levels in serum and the liver. F81-1144b also lowers VLDL-TAG secretion, de novo FA synthesis in the liver, and serum levels of insulin and glucose.
T71251	DS-1558
	DS-1558 is a potent and orally available GPR40 agonist.DS-1558 was found to have potent glucose lowering effects during an oral glucose tolerance test in ZDF rats. DS-1558 significantly and dose-dependently improved hyperglycemia and increased insulin secretion during the oral glucose tolerance test in Zucker fatty rats, the model of insulin resistance and glucose intolerance. DS-1558 not only increased the glucose-stimulated insulin secretion by GLP-1 but also potentiated the maximum insulinog...
TP1241	Adrenocorticotropic Hormone (ACTH) (18-39), human ACTH (18-39), human
	Adrenocorticotropic Hormone (ACTH) (18-39) is known as the Corticotropin-like Intermediate Lobe Peptide. It stimulates insulin secretion as well as amylase and protein secretion in a dose-dependent manner similar to those of secretin and carbamylcholine.
T71020	PF-04671536
	PF-04671536 is a highly potent and selective inhibitor of phosphodiesterase 8B (PDE8B) phosphodiesterase 8A (PDE8A). In primary human pancreatic islets, PF-04671536 increases insulin secretion in a glucose-dependent manner.
T40697	Glucocorticoids receptor agonist 2
	Glucocorticoid receptor agonist 2 is a highly effective anti-inflammatory compound, derived from arylpyrazole, that actively binds to and activates the glucocorticoid receptor. This compound exhibits potent anti-inflammatory properties without disrupting insulin secretion.
T40808	Glucocorticoids receptor agonist 1
	Glucocorticoids receptor agonist 1 (GRA-1) is a highly effective arylpyrazole-based compound that acts as an agonist for the glucocorticoid receptor. GRA-1 exhibits strong anti-inflammatory properties while maintaining insulin secretion function.
TP1630	A-71915 TFA (132956-87-7 free base) A-71915 TFA
	A-71915 (TFA) is a selective inhibitor of ANP receptor (atrial natriuretic peptide-receptor), induces apoptosis and decreases insulin secretion in RINm5F pancreatic β-cells.
TP2017	GIP (1-39)
	Endogenous truncated form of the incretin hormone GIP. More potent at stimulating glucose-dependent insulin secretion from rat pancreatic β-cells than GIP.
T69380	Cinnamic acid, hydrazide
	Cinnamic acid, hydrazide is an unsaturated carboxylic acid and precursor to aspartame via enzyme-catalysed amination to phenylalanine. Cinnamic acid may be useful in prevention or treatment of Diabetes through various mechanism of actions including stimulation of insulin secretion, improvement of pancreatic β-cell functionality, inhibition of hepatic gluconeogenesis, enhanced glucose uptake, increased insulin signaling pathway, delay of carbohydrate digestion and glucose absorption, and inhibiti...
T76041	GIP (1-30) amide,human acetate
	GIP (1-30) amide, human acetate 为葡萄糖依赖性促胰岛素多肽（GIP）的片段，作为一种肠降血糖素激素，它能在10^-9至10^-6M的剂量范围内，依赖剂量地促进胰岛素的分泌，并有效减缓餐后血糖波动。
T83694	Gastric Inhibitory Peptide (1-42) (porcine) TFA GIP (1-42),Glucose-dependent Insulinotropic Polypeptide (1-42)
	胃抑制肽(GIP) (1-42)是一种内源性的42氨基酸肽类肠促素激素，能诱导胰岛素分泌。该激素在肠道神经内分泌K细胞和颌下腺中表达，并在餐后释放到循环中。GIP (1-42)抑制由组胺、五肽和胰岛素引起的胃酸和胃蛋白酶分泌，增加葡萄糖诱导的胰岛素释放，并在大鼠中刺激胃排空。
T14215	AMG 837 sodium salt	Others	Others
	AMG 837 sodium salt is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. IC50 value: 13 nM (EC50) [1] Target: GPR40 agonist AMG 837 displayed the expected t
TP1566	GIP (1-30) amide (Human) (TFA)
	GIP (1-30) amide (Human) TFA is a glucose-dependent insulinotropic polypeptide fragment. Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone that stimulates insulin secretion and reduces postprandial glycaemic excursions.

化合物

Cat.No: T8348

Target: Adrenergic Receptor

Cat.No: T7127

Target: Apoptosis, GPR

Cat.No: T21623

Synonym: AS 1269574

Target: GPR, TRP/TRPV Channel

Cat.No: T40187

Target: DYRK

Cat.No: T3171

Synonym: GSK 137647

Target: GPR

Cat.No: T15247

Synonym: NSC 116966

Target: cAMP

GLP-1(7-37) acetate(106612-94-6 free base)

Cat.No: TP1376

Synonym: GLP-1(7-37) acetate

Target: Others, Glucagon Receptor

HAEGTFTSDVS acetate

Cat.No: TP1382L

Synonym: HAEGTFTSDVS acetate(864915-61-7 free base)

Target: Glucagon Receptor

GIP (1-39) acetate

Cat.No: TP2017L

Synonym: GIP (1-39) acetate(725474-97-5 Free base)

Target: Others

Glucagon (19-29), human acetate

Cat.No: TP1863L

Target: Glucagon Receptor

GIP (human) acetate

Cat.No: TP2018L

Synonym: GIP (human) acetate(100040-31-1 Free base)

Target: IGF-1R

Glymidine sodium

Cat.No: T31976

Target: Others

Cat.No: T1088

Synonym: AG-EE 388 ZW,AG-EE 623ZW,瑞格列奈

Target: Potassium Channel, PPAR

Cat.No: T1781

Synonym: GW 9508

Target: GPR, Potassium Channel

Mitiglinide Calcium

Cat.No: T6587

Synonym: KAD-1229,米格列奈钙,S21403,米格列奈

Target: ATPase, Potassium Channel

GIP (1-30) amide, porcine acetate

Cat.No: T37588L

Target: IGF-1R

Rosiglitazone hydrochloride

Cat.No: T6646

Synonym: 盐酸罗格列酮,BRL-49653 HCl,Rosiglitazone HCl

Target: Ferroptosis, TRP/TRPV Channel, PPAR, Autophagy

Cat.No: T17177

Synonym: TUG424

Target: Others

Cat.No: T13867

Target: Others

Cat.No: T1674

Synonym: 那格列奈,A4166,Senaglinide

Target: Potassium Channel, Proteasome, PPAR

Mazdutide acetate（2259884-03-0 free base）

Cat.No: T78097L

Synonym: Mazdutide acetate（2259884-03-0 free base）,OXM-3 acetate,LY-3305677 acetate,IBI-362 acetate

Target: Glucagon Receptor

Mitiglinide calcium hydrate

Cat.No: T1530

Synonym: KAD-1229 calcium hydrate,米格列奈钙,Mitiglinide calcium,S-21403 calcium hydrate

Target: Potassium Channel

Galantide acetate

Cat.No: T15368L

Synonym: Galantide acetate(138579-66-5 Free base)

Target: Neuropeptide Y Receptor

Cat.No: T34470

Synonym: RX-801080,RX 801080,S9871,RX801080,S-9871

GLP-1(7-36), amide acetate

Cat.No: TP1141

Synonym: GLP-1(7-36) Acetate,Human GLP-1-(7-36)-amide Acetate

Cat.No: T25739

Synonym: McN-3935,McN3935,McN 3935,Linogliridum,Linoglirida

Cat.No: TP2258

Target: Others

Cat.No: T70373

Cat.No: T70113

GLP-1(7-36), amide TFA

Cat.No: T37892

GIP (1-30) amide,human

Cat.No: TP1584

Synonym: GIP (1-30) amide (Human)

Cat.No: TP2209

Target: Others

Cat.No: T24620

Synonym: PF-0637222,PF0637222,PF 0637222

C-Peptide 2, rat

Cat.No: T40518

Cat.No: T27938

Synonym: LY 2922083,LY-2922083

Linogliride fumarate

Cat.No: T25739L

Synonym: McN 3935,McN-3935,McN3935

Cat.No: T62836

Cat.No: T69477

Cat.No: T71251

Adrenocorticotropic Hormone (ACTH) (18-39), human

Cat.No: TP1241

Synonym: ACTH (18-39), human

Cat.No: T71020

Glucocorticoids receptor agonist 2

Cat.No: T40697

Glucocorticoids receptor agonist 1

Cat.No: T40808

A-71915 TFA (132956-87-7 free base)

Cat.No: TP1630

Synonym: A-71915 TFA

Cat.No: TP2017

Cinnamic acid, hydrazide

Cat.No: T69380

GIP (1-30) amide,human acetate

Cat.No: T76041

Gastric Inhibitory Peptide (1-42) (porcine) TFA

Cat.No: T83694

Synonym: GIP (1-42),Glucose-dependent Insulinotropic Polypeptide (1-42)

AMG 837 sodium salt

Cat.No: T14215

Target: Others

GIP (1-30) amide (Human) (TFA)

Cat.No: TP1566

Cat. No.	Product Name	Target	Signaling Pathways
T1286	Vincamine Angiopac,Oxybral,Devincan,Novicet,Equipur,长春胺,Perval	GPR; Others	Endocrinology/Hormones; GPCR/G Protein; Others
	Vincamine (Perval) 是从长春花中提取的单萜类吲哚生物碱，可作为外周血管扩张剂，对脑微血管循环有选择性的血管调节作用。它可改善体内葡萄糖稳态，对 2 型糖尿病具有研究潜力。它是GPR40激动剂，通过改善 β 细胞功能障碍和促进葡萄糖刺激型胰岛素分泌发挥 β 细胞保护作用。
T2755	Rhoifolin 野漆树苷,Apigenin-7-O-rhamnoglucoside,Apigenin 7-O-neohesperidoside,Rhoifoloside	Others; p38 MAPK; NF-κB; transporter; IGF-1R; Autophagy	Autophagy; MAPK; Metabolism; NF-κB; Others; Tyrosine Kinase/Adaptors
	Rhoifolin (Apigenin 7-O-neohesperidoside) 是从琯溪蜜柚叶子分离的一种黄酮糖苷。它通过 RANKL 诱导的NF-κB 和MAPK 途径改善钛颗粒刺激的骨溶解并减少破骨细胞生成。它通过增强脂联素分泌，胰岛素受体-β的酪氨酸磷酸化和GLUT4易位有助于治疗糖尿病并发症。
T4S0295	Apigenin 7-glucoside 波斯菊,Cosmetin,Cosmosiin,Cosmosioside,Apigenin-7-O-β-D-glucopyranoside,芹甙元-7-葡萄糖苷,Thalictiin,Apigetrin	Reactive Oxygen Species; HIV Protease	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
	Apigenin 7-glucoside (Cosmosiin) 是一种 ROS 清除剂，具有抗增殖、抗氧化作用。
T2P2919	(2S,3R,4S)-4-Hydroxyisoleucine (4S)-4-Hydroxy-L-isoleucine,(4S)4-羟基异亮氨酸,Hydroxyisoleucine	PI3K	PI3K/Akt/mTOR signaling
	(2S,3R,4S)-4-Hydroxyisoleucine (Hydroxyisoleucine) 是分离自胡芦巴中的一种可口服的有效成分，具有抗糖尿病、抗糖尿病肾病的作用。
T2740	trans-Cinnamic acid Isocinnamic acid,反式肉桂酸,Cinnamic acid,trans-3-Phenylacrylic acid,Phenylacrylic acid,Cinnamylic acid,3-Phenylacrylic acid,肉桂酸,Myricitrine	Endogenous Metabolite; Antibacterial	Metabolism; Microbiology/Virology
	trans-Cinnamic acid (Myricitrine) 通过改善体内葡萄糖耐量和体外刺激胰岛素分泌而发挥抗糖尿病活性。它是一种杀菌剂，对鱼的病原菌温和气单胞菌的 MIC 值为 250 μg/mL。
T3863	Chikusetsusaponin IVa 竹节参皂苷IVa,Calenduloside F,竹节人参皂苷 IVA	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Chikusetsusaponin IVa (Calenduloside F) 是一种三萜皂苷中主要的活性成分，是一种蛋白激酶的激活剂，对血栓及一些代谢性疾病具有抵抗作用。
TWS1563	Incensole	Others	Others
	Incensole 是一种 14-membered 二萜类化合物，分离自烯属植物的香精油和乳香树脂中。它能够激活脑中离子通道，并可以缓解焦虑或抑郁，从而显示出抗炎和抗抑郁的特性。
TN2215	Taurochenodeoxycholic acid sodium 牛磺鹅去氧胆酸钠盐,Sodium taurochenodeoxycholate,牛磺鹅去氧胆酸钠	Apoptosis; Endogenous Metabolite	Apoptosis; Metabolism
	Taurochenodeoxycholic acid sodium (Sodium taurochenodeoxycholate) 是动物胆汁酸的主要生物活性物质之一。它可诱导细胞凋亡，具有抗炎和免疫调节作用。
TWO2727	Propane-1,2,3-triyl tripalmitate Palmitic Triglyceride,Tripalmitin,Tripalmitoylglycerol,Glycerol Tripalmitate,三棕榈酸甘油酯	Others; Endogenous Metabolite	Metabolism; Others
	Propane-1,2,3-triyl tripalmitate (Glycerol Tripalmitate) 是内源性代谢产物的一种。
TN4577	Momordicoside X	Others	Others
	Momordicoside X displays moderate insulin secretion activity.
TN4576	Momordicine II	Others	Others
	Momordicine II may have antidiabetic activity, it significantly stimulated insulin secretion. It also can deter oviposition by L. trifolii significantly.
T40977	Cinnamtannin A2 肉桂鞣质A2
	Cinnamtannin A2, a tetrameric procyanidin, enhances GLP-1 and insulin secretion in mice while also upregulating the expression of corticotrophin releasing hormone. Additionally, Cinnamtannin A2 exhibits antioxidant, anti-diabetic, and nephroprotective effects.
TN4997	Serpentine	IGF-1R	Tyrosine Kinase/Adaptors
	Serpentine 是一种玫瑰花根中的生物碱，可用作胰岛素增敏剂，以协助胰岛素降低血糖。Serpentine 可激活 AMPK 磷酸化，从而刺激C2C12细胞对葡萄糖的摄取。Serpentine 可增加了肌肉组织中GSK-3β mRNA的表达，从而增强葡萄糖摄取。Serpentine 显著增加胰高血糖素分泌和肝糖异生。在高脂肪饮食/链脲佐菌素（HFD/STZ）诱导的糖尿病小鼠中，Serpentine 显著延长了胰岛素的降血糖时间，显著降低了外源性胰岛素的使用，抑制了内源性胰岛素的分泌。
T20232	Kazinol B	Akt; NO Synthase; AMPK	Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; PI3K/Akt/mTOR signaling
	Kazinol B 是一氧化氮（NO）产生的抑制剂，是一种具有二甲基吡喃环的异戊烯化黄烷。Kazinol B 通过激活胰岛素-Akt 信号途径和AMPK，增强葡萄糖摄取，从而改善胰岛素敏感性。Kazinol B 刺激脂肪素的基因表达和分泌，可用于研究糖尿病。
TN1938	Mogroside VI 罗汉果甜苷 VI,罗汉果甜苷VI	Antifection	Microbiology/Virology
	Lo Han Kuo extract is a high intensive sweetening agent with desirable health benefits, such as prevention of dental caries through specific antibacterial properties, no-calorie levels related to obesity, and a low glycemic index to help manage blood suga

天然产物

Cat.No: T1286

Synonym: Angiopac,Oxybral,Devincan,Novicet,Equipur,长春胺,Perval

Target: GPR, Others

Cat.No: T2755

Synonym: 野漆树苷,Apigenin-7-O-rhamnoglucoside,Apigenin 7-O-neohesperidoside,Rhoifoloside

Target: Others, p38 MAPK, NF-κB, transporter, IGF-1R, Autophagy

Apigenin 7-glucoside

Cat.No: T4S0295

Synonym: 波斯菊,Cosmetin,Cosmosiin,Cosmosioside,Apigenin-7-O-β-D-glucopyranoside,芹甙元-7-葡萄糖苷,Thalictiin,Apigetrin

Target: Reactive Oxygen Species, HIV Protease

(2S,3R,4S)-4-Hydroxyisoleucine

Cat.No: T2P2919

Synonym: (4S)-4-Hydroxy-L-isoleucine,(4S)4-羟基异亮氨酸,Hydroxyisoleucine

Target: PI3K

trans-Cinnamic acid

Cat.No: T2740

Synonym: Isocinnamic acid,反式肉桂酸,Cinnamic acid,trans-3-Phenylacrylic acid,Phenylacrylic acid,Cinnamylic acid,3-Phenylacrylic acid,肉桂酸,Myricitrine

Target: Endogenous Metabolite, Antibacterial

Chikusetsusaponin IVa

Cat.No: T3863

Synonym: 竹节参皂苷IVa,Calenduloside F,竹节人参皂苷 IVA

Target: AMPK

Cat.No: TWS1563

Target: Others

Taurochenodeoxycholic acid sodium

Cat.No: TN2215

Synonym: 牛磺鹅去氧胆酸钠盐,Sodium taurochenodeoxycholate,牛磺鹅去氧胆酸钠

Target: Apoptosis, Endogenous Metabolite

Propane-1,2,3-triyl tripalmitate

Cat.No: TWO2727

Synonym: Palmitic Triglyceride,Tripalmitin,Tripalmitoylglycerol,Glycerol Tripalmitate,三棕榈酸甘油酯

Target: Others, Endogenous Metabolite

Momordicoside X

Cat.No: TN4577

Target: Others

Cat.No: TN4576

Target: Others

Cinnamtannin A2

Cat.No: T40977

Synonym: 肉桂鞣质A2

Cat.No: TN4997

Target: IGF-1R

Cat.No: T20232

Target: Akt, NO Synthase, AMPK

Cat.No: TN1938

Synonym: 罗汉果甜苷 VI,罗汉果甜苷VI

Target: Antifection

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