store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Rosiglitazone hydrochloride (BRL-49653 HCl) 是一种降血糖药物,通过与脂肪细胞中的 PPAR 受体结合来刺激胰岛素分泌。它对 PPARγ1、PPARγ2 和 PPARγ 的EC50值分别为 30 nM、100 nM 和 60 nM。它也是TRPC5的激活剂和TRPM3的抑制剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 158 | 现货 | ||
10 mg | ¥ 218 | 现货 | ||
25 mg | ¥ 343 | 现货 | ||
50 mg | ¥ 496 | 现货 | ||
100 mg | ¥ 719 | 现货 | ||
200 mg | ¥ 1,050 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 196 | 现货 |
产品描述 | Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells. |
靶点活性 | PPARγ2:100 nM (EC50), PPARγ1:30 nM (EC50) |
体外活性 | Bafetinib blocks WT Bcr-Abl autophosphorylation and its downstream kinase activity with IC50 of 11 nM and 22 nM in K562 and 293T cells, respectively. Bafetinib suppresses the growth of the Bcr-Abl-positive cell lines including K562, KU812, and BaF3/wt cells potently without effects on the proliferation of the Bcr-Abl-negative U937 cell line. Moreover, Bafetinib exhibits a dose-dependent antiproliferative effect against Bcr-Abl point mutant cell lines, such as BaF3/E255K cells. [1] In Bcr-Abl+ leukemia cell lines, Bafetinib induces both caspase-mediated and caspase-independent cell death by blocking the phosphorylation of Bcr-Abl. [2] |
别名 | 盐酸罗格列酮, BRL-49653 HCl, Rosiglitazone HCl |
分子量 | 393.89 |
分子式 | C18H19N3O3S·HCl |
CAS No. | 302543-62-0 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 73 mg/mL (185.3 mM)
DMSO: 73 mg/mL (185.3 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
Ethanol / DMSO | 1 mM | 2.5388 mL | 12.6939 mL | 25.3878 mL | 63.4695 mL |
5 mM | 0.5078 mL | 2.5388 mL | 5.0776 mL | 12.6939 mL | |
10 mM | 0.2539 mL | 1.2694 mL | 2.5388 mL | 6.3469 mL | |
20 mM | 0.1269 mL | 0.6347 mL | 1.2694 mL | 3.1735 mL | |
50 mM | 0.0508 mL | 0.2539 mL | 0.5078 mL | 1.2694 mL | |
100 mM | 0.0254 mL | 0.1269 mL | 0.2539 mL | 0.6347 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
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