首页工具

登录

搜索结果

Search Results for " increases apoptosis "

60

抑制剂 & 化合物

11

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T23861	CAY10526 CAY-10526,BTH,CAY 10526	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	CAY10526 (BTH) 是 mPGES-1 的选择性抑制剂，可抑制 NF-κB 信号通路。
T11209	EOAI3402143	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	EOAI3402143 是一种去泛素化酶抑制剂，以剂量依赖性抑制 Usp9x/Usp24和 Usp5，增加肿瘤细胞凋亡。
T22094	JGB1741 ILS-JGB-1741	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	JGB1741 (ILS-JGB-1741) 是一种有效的选择性 SIRT1 抑制剂，IC50 为 15 μM。 JGB1741 调节 Bax/Bcl2 比率、细胞色素 c 释放和 PARP 裂解并增加乙酰化 p53 水平，导致 p53 介导的细胞凋亡。 JGB1741可用于乳腺癌研究。
T15469	Hematein Hydroxybrasilein	Wnt/beta-catenin; Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Stem Cells
	Hematein 抑制Akt/PKB Ser129磷酸化，Wnt/TCF 途径，并增加癌症细胞的凋亡。Hematein 是苏木精的氧化产物，也是变构酪蛋白激酶II 抑制剂（IC50:0.74μM）。
T83653	SACLAC	Apoptosis; Caspase	Apoptosis; Proteases/Proteasome
	SACLAC 是一种半胱天冬酶活化抑制剂，具有抗肿瘤活性，可降低AML细胞活力，抑制AML细胞增殖，增加AML细胞死亡，并诱导AML细胞凋亡，可用于研究急性髓系白血病和癌症。
T63992	KS100
	KS100 是 ALDH 的有效抑制剂，能够作用于 ALDH1A1 (IC50: 334 nM)、ALDH2 (IC50: 2137 nM) 和 ALDH3A1 (IC50: 360 nM)。KS100 能够明显提高 ROS 活性、脂质过氧化和有毒醛的积累，且具有低毒性的抗增殖和抗癌活性。KS100 能够将细胞周期阻滞在 G2/M 期，并诱导细胞凋亡 (apoptosis)。
T14021	20-HETE 20-hydroxy Arachidonic Acid	Others	Others
	20-HETE (20-hydroxy Arachidonic Acid) is a CYP450 metabolite and a potent vasoconstrictor and it is an endogenous inhibitor of the large-conductance Ca2+-activated K+ channel in renal arterioles. 20-HETE increases NADPH oxidase, ROS, and NF-κB activity, a
T68170	xl-281
	XL-281是一种有效的,选择性的,口服活性的野生型和突变型 RAF 激酶抑制剂,在多种异种移植模型中具有抗肿瘤活性；通过调节肿瘤和替代组织中的 RAF 途径证明生物活性,细胞增殖减少,细胞凋亡增加。
T38034	MAO-IN-M30 dihydrochloride M 30 dihydrochloride	Monoamine Oxidase	Neuroscience
	MAO-IN-M30 dihydrochloride (M 30 dihydrochloride) 是一种口服活性，可通过血脑屏障的，脑选择性不可逆 MAO-A (IC50=37 nM) 和 MAO-B (IC50=57 nM) 抑制剂。MAO-IN-M30 dihydrochloride 是有效的铁螯合剂、自由基清除剂。MAO-IN-M30 dihydrochloride 对 Dexamethasone 诱导的脑细胞凋亡具有神经保护作用。MAO-IN-M30 dihydrochloride 在 MPTP 和 lactacystin 帕金森病模型中也显示出神经恢复活性。
T38294	4-Deoxypyridoxine hydrochloride	S1P Receptor	GPCR/G Protein
	4-Deoxypyridoxine hydrochloride 通过抑制 S1P 裂解酶 (SPL) 活性来抑制细胞内 S1P 的降解，与 S1P 一样，减少化学诱导的胰岛素瘤细胞系的细胞凋亡。
T35689	MTP 131 acetate	Others	Others
	MTP 131 acetate 是一种小的线粒体靶向四肽。
T35610	2,5-dimethyl Celecoxib	Apoptosis; Wnt/beta-catenin; Prostaglandin Receptor	Apoptosis; Cytoskeletal Signaling; GPCR/G Protein; Immunology/Inflammation; Stem Cells
	2,5-dimethyl Celecoxib 是塞来昔布衍生物和微粒体前列腺素 E 合酶 1 (mPGES-1) 的靶向抑制剂，mPGES-1 是炎症介质 PGE2 合成途径中的关键酶。
T36083	DS-7423	PI3K; mTOR	PI3K/Akt/mTOR signaling
	DS-7423 是PI3K 和mTOR 的有效抑制剂，抑制PI3Kα 和 mTOR 的IC50分别为15.6 nM 和 34.9 nM。DS-7423表现出抗癌活性。
T28027	Methotrexate monohydrate Methotrexate hydrate
	Methotrexate monohydrate is a DHhF reductase inhibitor. Methotrexate monohydrate increases T cell apoptosis, decreases T cell activation and suppresses cytokine production.
T32419	KRAS4b-PDEδ stabilizer C19
	KRAS4b-PDEδ stabilizer C19 is a stabilizer of the KRAS4b-PDEδ complex which decreases the proliferation of colorectal cancer cells, and increases apoptosis via decreased activation of oncogenic KRAS4b signaling.
T71830	DT204
	DT204 is a SCFSkp2 inhibitor which blocks Skp2 binding to Cullin-1 and Commd1, thereby synergistically enhancing BTZ-induced apoptosis and stabilization. DT204 also increases p27 levels.
T36944	Ara-G	Nucleoside Antimetabolite/Analog	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Ara-G 是一种脱氧鸟苷 (GdR) 类似物和核苷类似物，可被 T 淋巴谱系细胞迅速转化为其相应的阿拉伯糖基鸟嘌呤核苷酸三磷酸 (araGTP)，从而抑制 DNA 合成和对 T 淋巴母细胞的选择性体外毒性细胞系以及来自 T 细胞急性淋巴细胞白血病 (ALL) 患者的新鲜分离的白血病细胞。
T63917	Anticancer agent 67
	Anticancer agent 67 是环丙沙星类似物，是一种抗癌剂，在 MCF-7 细胞中能够诱导细胞凋亡 (apoptosis) 并增加亚 G1 细胞群。
T69429	Y27632 HCl hydrate
	Y27632 is a selective ROCK inhibitor, which inhibits ET-1-induced increases in natriuretic peptide production, cell size, protein synthesis, and myofibrillar organization. Y27632 prevents dimethylnitrosamine-induced hepatic fibrosis in rats, increases apoptosis and disrupts the actin cortical mat in embryonic avian corneal epithelium, affects initial heart myofibrillogenesis in cultured chick blastoderm, promotes the proliferation and cell cycle progression of cultured astrocyte from spinal cord...
T63477	PI3Kα-IN-8
	PI3Kα-IN-8 是 PI3Kα 的选择性抑制剂 (IC50: 0.012 μM)。PI3Kα-IN-8 能够提高细胞内活性氧（reactive oxygen species）水平，降低线粒体膜电位，诱导细胞凋亡（apoptosis）。
TP2296	TLQP-21	Others	Others
	TLQP 21 is a VGF-derived peptide. TLQP 21 can protect cerebellar granule cells (CGCs) from serum and potassium deprivation-induced apoptosis and increases energy expenditure and prevents early phase diet-induced diabetes.
T36610	(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine
	(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine (CSTMP) is a stilbene derivative with antioxidant and anticancer activities. It stimulates proliferation of hydrogen peroxide-damaged ECV-304 cells (EC50 = 24.9 nM). CSTMP reduces hydrogen peroxide-induced release of lactate dehydrogenase (LDH) in and increases viability of human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner via inhibition of apoptosis. It reverses hydrogen peroxide-induced release of malondialdehyde ...
T36507	Tetrachlorohydroquinone
	Tetrachlorohydroquinone (TCHQ) is a metabolite of the organochlorine biocide pentachlorophenol. It is cytotoxic to RTL-W1 rainbow trout liver cells (EC50 = 1.55 μM in a neutral red assay). TCHQ increases production of reactive oxygen species (ROS), inhibits apoptosis, and induces loss of the mitochondrial membrane potential and necrosis in splenocytes. In vivo, TCHQ induces glutathione (GSH) depletion in mouse liver.
T62073	PI3Kα-IN-6
	PI3Kα-IN-6 (Compound 5b) 是一种 PI3Kα 抑制剂，表现出抗癌作用，对正常的细胞不具有毒性。PI3Kα-IN-6 能够提高 ROS 的产生，降低线粒体膜电位，诱导细胞凋亡 (apoptosis)。
T36073	S-Acetyl-L-glutathione
	S-Acetyl-L-glutathione is a derivative of glutathione .1 It increases intracellular GSH levels in primary fibroblasts derived from patients with glutathione synthetase deficiency when used at a concentration of 50 μM. S-Acetyl-L-glutathione (5 mM) induces apoptosis in Daudi, Raji, and Jurkat lymphoma cells.2 It inhibits the replication of herpes simplex virus 1 (HSV-1) in human foreskin fibroblasts when used at concentrations of 5 and 10 mM.3 S-Acetyl-L-glutathione (6.25 μg/g per day) increases ...
T79482	Anticancer agent 137	PI3K	PI3K/Akt/mTOR signaling
	Anticanceragent 137 (8q) 是一种高效的 PI3k 抑制剂，展现出广谱的抗肿瘤活性。它能够诱导 G2/M 阶段的细胞周期阻滞与细胞凋亡（apoptosis），并促进 PARP、caspase 3 和 caspase 7 的裂解。该化合物主要用于癌症相关的生物医学研究。
T75823	GLP-2(rat) TFA
	GLP-2(rat) TFA为肠道生长因子，能刺激细胞增殖、抑制凋亡，且在大肠小肠切除术(MSBR)后，可提升残留小肠粘膜的品质与功能。
T63452	Benidipine
	Benidipine 是一种有效的、口服具有活力的钙通道拮抗剂。Benidipine 能够提高内皮细胞型一氧化氮合酶的活性，改善高血压大鼠冠状动脉循环。Benidipine 能够抗缺血/再灌注心肌细胞的凋亡。
T64022	Antitumor agent-37
	Antitumor agent-37 表现出有效的抗增殖和抗转移效果。Antitumor agent-37 能够诱导严重的 DNA 损伤，进而导致 γ-H2AX 和 p53 的高表达。Antitumor agent-37 可利用线粒体凋亡通路 Bcl-2/Bax/caspase3，诱导肿瘤细胞凋亡 (apoptosis)。Antitumor agent-37 可以抑制 PD-L1 的表达，提高肿瘤组织中 CD3+ 和 CD8+ T 浸润细胞，明显改善免疫反应。
T15670	KT5823	Apoptosis; PKA	Apoptosis; Tyrosine Kinase/Adaptors
	KT5823 是一种具有选择性和有效性的 cGMP 依赖性蛋白激酶 (PKG) 抑制剂，对 PKA 和 PKG 有抑制作用。KT5823 在甲状腺细胞中通过调节碘化钠交感蛋白的表达和活性来增加甲状腺刺激激素诱导的 (Na+/I- symporter) NIS 表达和碘离子摄取。 KT5823 诱导细胞凋亡。
T36221	2-chloro Palmitic Acid
	2-chloro Palmitic acid is a monochlorinated form of palmitic acid . It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate . 2-chloro Palmitic acid (10 μM) induces neutrophil extracellular trap (NET) formation (NETosis) in human neutrophils, increasing DNA release from neutrophils, colocalization of MPO with extracellular DNA (ecDNA), and trapping of E. coli. It increases COX-2 protein levels in human coronary artery endot...
T36321	C6 Urea Ceramide
	C6 urea ceramide is an inhibitor of neutral ceramidase.1 It increases total ceramide levels in wild-type mouse embryonic fibroblasts (MEFs) and in HT-29 colon cancer cells but not in MEFs lacking neutral ceramidase. It inhibits proliferation of, and induces apoptosis and autophagy in HT-29, but not non-cancerous RIE-1, cells when used at concentrations of 5 and 10 μM. C6 urea ceramide decreases total β-catenin, increases phosphorylated β-catenin, and induces colocalization of β-catenin with the ...
T76252L	WLSEAGPVVTVRALRGTGSW TFA
	WLSEAGPVVTVTVRALGTGSW TFA 为心肌细胞特异性肽。该化合物通过表达外泌体，提高心肌细胞的特定摄取能力，降低心肌细胞凋亡率，并在体内心肌内注射后提升心脏潴留能力。
T36099	Jacaric Acid
	Jacaric acid is a conjugated polyunsaturated fatty acid first isolated from seeds of Jacaranda plants. Structurally, it is an 18-carbon ω-6 triene isomer of γ-linolenic acid . Jacaric acid induces cell cycle arrest and apoptosis in a variety of cancer cell lines (GI50 = 1-5 μM). It increases the production of reactive oxygen species, and cytotoxicity is abolished by the antioxidant α-tocopherol, suggesting that apoptosis results from oxidative stress. Jacaric acid is metabolized in vivo to conju...
T63179	BTK-IN-9
	BTK-IN-9 是一种 BTK 的可逆抑制剂，在套细胞淋巴瘤细胞中显示出较强的抗增殖作用。BTK-IN-9 能够特异性地扰乱线粒体膜电位，提高 Z138 细胞中的活性氧水平，并诱导 Z138 细胞凋亡。
T36098	Isovaleryl-L-carnitine (chloride)
	Isovaleryl-L-carnitine is a naturally occurring acylcarnitine that is formed via metabolic conversion of L-leucine. It increases survival and decreases apoptosis in hepatocyte growth factor-deprived murine C2.8 hepatocytes when used at a concentration of 1 mM. Isovaleryl-L-carnitine inhibits amino acid deprivation-induced proteolysis and autophagy in isolated perfused rat liver when used at concentrations of 77 and 100 μM, respectively. Increased levels of isovaleryl carnitine are associated wit...
T62111	Antioxidant agent-5
	Antioxidant agent-5 (compound D-6) 是一种有效的抗氧化剂。Antioxidant agent-5 能够抑制 oxLDL 诱导的 ROS 水平升高和 NF-κB 核转位。Antioxidant agent-5 对 oxLDL (氧化型低密度脂蛋白)诱导的 VECs 细胞凋亡 (apoptosis) 及 ICAM-1 和 VCAM-1 的表达表现出抑制作用。Antioxidant agent-5 可以激活 Nrf2/HO-1 抗氧化通路，对 oxLDL 诱导的内皮损伤表现出保护活性。
T63879	microRNA-21-IN-1
	microRNA-21-IN-1（compound 7A）是一种高效microRNA抑制剂，对Hela和HCT-116细胞显示出抗增殖活性，IC50值分别为5.5 μM和2.8 μM，并能促进Hela细胞凋亡(apoptosis)。该化合物通过上调microRNA-21下游功能靶点（PTEN、EGR1、SLIT2）的表达，有助于抗癌研究。
T63494	Antitumor agent-60
	Antitumor agent-60 是有效的抗肿瘤药物，靶向RAS-RAF 信号通路，可与CRAF 结合 (Kd: 721.3 nM)。Antitumor agent-60 能增加癌细胞中p53和ROS 水平，使细胞核呈椭圆形和不规则形态。Antitumor agent-60 够将细胞的细胞周期阻滞在 G2/M 期，并诱导细胞凋亡 (apoptosis)。在 A549 肿瘤移植模型中，Antitumor agent-60 具有一定的抑制肿瘤生长能力。
T38389	Prostaglandin D2 Ethanolamide Prostaglandin D2 Ethanolamide
	Prostaglandin D2 ethanolamide (PGD2-EA) is a bioactive lipid produced by the sequential metabolism of anandamide (arachidonoyl ethanolamide) by cyclooxygenase (COX) enzymes, in particular by COX-2, and PGD synthase. The biosynthesis of PGD2-EA from anandamide can also be increased when anandamide metabolism is diminished by deletion of fatty acid amide hydrolase. PGD2-EA is inactive against recombinant prostanoid receptors, including the D prostanoid receptor. It increases the frequency of minia...
T71285	Metaxalone-d6
	Metaxalone-d6 is intended for use as an internal standard for the quantification of metaxalone by GC-or LC-MS. Metaxalone is a skeletal muscle relaxant. It inhibits the proliferation of, and induces apoptosis in, RAW 264.7 cells in vitro when used at concentrations ranging from 1 to 100 µM. Metaxalone also reduces LPS-induced increases in COX-1, COX-2, and NF-kB levels and inhibits LPS-induced production of TNF-α, IL-6, and prostaglandin E2 in RAW 264.7 cells. Formulations containing metaxalone ...
T35622	FKGK 18
	FKGK 18 is an inhibitor of group VIA (GVIA) calcium-independent phospholipase A2 (iPLA2). It inhibits GVIA iPLA2 by 99.9% at 0.091 mole fraction in a mixed micelle activity assay and is selective for GVIA iPLA2 over GIVA cPLA2 and GV sPLA2 where it shows 80.8 and 36.8% inhibition, respectively. FKGK 18 inhibits iPLA2β activity in cytosolic extracts from INS-1 cells overexpressing iPLA2β (IC50 = ~50 nM) as well as iPLA2γ activity in mouse heart membrane fractions (IC50s = ~1-3 μM). It inhibits gl...
T79274	PRMT5-IN-31	Histone Methyltransferase	Chromatin/Epigenetic
	PRMT5-IN-31（Compound 3m）作为一种高选择性PRMT5抑制剂，其IC50为0.31 μM。它能够通过占据PRMT5的底物位点以及与氨基酸残基形成必要相互作用来上调hnRNP E1蛋白水平。此外，PRMT5-IN-31能有效抑制A549细胞增殖，其机制涉及诱导apoptosis和阻碍细胞迁移。该化合物在人肝微粒体中表现出较高的代谢稳定性，半衰期为132.4分钟。
T60453	TrxR-IN-3
	TrxR-IN-3 (Compound 2c) 是TrxR 的有效抑制剂。TrxR-IN-3 对五种人类癌细胞系表现出强大的抗增殖活性，特别是对乳腺肿瘤细胞。TrxR-IN-3 增加 ROS 水平并通过调节乳腺癌细胞中细胞凋亡相关蛋白的表达导致明显的细胞凋亡。TrxR-IN-3 还通过促进 LC3-II 和 Beclin-1 的表达并减少 LC3-I 和 p62 蛋白的表达，来触发自噬体和自溶酶体的形成。
T37469	Sitamaquine tosylate
	Sitamaquine is an antileishmanial agent.1It is active againstL. donovani,L. infantum,L. mexicana,L. braziliensis, andL. tropica(EC50s = 9.5-19.8 μM). It inhibits mitochondrial complex II, also known as succinate dehydrogenase (SDH), in a cell-free assay when used at concentrations ranging from 10 to 200 μM.2Sitamaquine (100 μM) increases intracellular levels of reactive oxygen species (ROS) and decreases intracellular ATP levels, as well as induces phosphatidylserine externalization, chromatin f...
T36194	CAY10726 CAY10726
	CAY10726 is an arylurea fatty acid. It decreases ATP production by 28% in MDA-MB-231 breast cancer cells when used at a concentration of 10 μM. CAY10726 decreases proliferation and initiates apoptosis in MDA-MB-231 cells via depletion of the phospholipid cardiolipin and its precursor phosphatidylglycerol from the mitochondrial membrane. In vivo, CAY10726 (2.5-40 mg/kg) reduces tumor volume and increases tumor cell apoptosis in a mouse MDA-MB-231 breast cancer xenograft model in a dose-dependent ...
T35552	Ganglioside GD3 Mixture (sodium salt)
	Ganglioside GD3 is synthesized by the addition of two sialic acid residues to lactosylceramide and can serve as a precursor to the formation of more complex gangliosides by the action of glycosyl- and sialyltransferases. It induces apoptosis in HuT-78 cutaneous T cell lymphoma cells in a concentration-dependent manner and disrupts the mitochondrial membrane potential when used at a concentration of 200 μM. Expression of ganglioside GD3 in GD3-negative SK-MEL-28-N1 malignant melanoma cells increa...
T35778	Ochratoxin A-13C20 Ochratoxin A-13C20
	Ochratoxin A-13C20is intended for use as an internal standard for the quantification of ochratoxin A by GC- or LC-MS. Ochratoxin A is a mycotoxin that has been found inAspergillusandPenicillium.1It increases lipid peroxide levels and the number of apoptotic cells, as well as reduces superoxide dismutase activity in rat kidney when administered at a dose of 120 μg/kg.2Topical application of ochratoxin A (80 μg/mouse) induces DNA damage, cell cycle arrest at the G0/G1phase, and apoptosis in mouse ...
T36882	CAY10773
	CAY10773 is a derivative of the ferroptosis inducer sorafenib .1It selectively inhibits proliferation of BEL-7402, MGC803, and T24 bladder cancer cells (IC50s = 5.77, 5.21 and 3.97 μM, respectively) over non-cancerous HCV-29 cells (IC50= 23.19 μM). CAY10773 induces apoptosis in T24 cells when used at concentrations ranging from 2 to 6 μM but induces ferroptosis at concentrations greater than or equal to 6 μM with 10 hour or longer incubation times. It increases the production of reactive oxygen ...
T35762	MC1742
	MC1742 is an inhibitor of class I histone deacetylases (HDACs; IC50s = 0.1, 0.11, 0.02, and 0.61 μM for HDAC1, -2, -3, and -8, respectively) and class IIb HDACs (IC50s = 7 and 40 nM for HDAC6 and HDAC10, respectively).1 It is selective for class I and class IIb over class IIa HDACs (IC50s = >50 μM for HDAC4, -5, -7, and -9). MC1742 reduces proliferation of HOS, MG-63, RD, A204, SK-ES-1, and A673 sarcoma cancer stem cells (CSCs). It increases levels of acetylated histone H3 and acetylated tubulin...

化合物

Cat.No: T23861

Synonym: CAY-10526,BTH,CAY 10526

Target: Prostaglandin Receptor

Cat.No: T11209

Target: DUB

Cat.No: T22094

Synonym: ILS-JGB-1741

Target: Sirtuin

Cat.No: T15469

Synonym: Hydroxybrasilein

Target: Wnt/beta-catenin, Akt

Cat.No: T83653

Target: Apoptosis, Caspase

Cat.No: T63992

Cat.No: T14021

Synonym: 20-hydroxy Arachidonic Acid

Target: Others

Cat.No: T68170

MAO-IN-M30 dihydrochloride

Cat.No: T38034

Synonym: M 30 dihydrochloride

Target: Monoamine Oxidase

4-Deoxypyridoxine hydrochloride

Cat.No: T38294

Target: S1P Receptor

MTP 131 acetate

Cat.No: T35689

Target: Others

2,5-dimethyl Celecoxib

Cat.No: T35610

Target: Apoptosis, Wnt/beta-catenin, Prostaglandin Receptor

Cat.No: T36083

Target: PI3K, mTOR

Methotrexate monohydrate

Cat.No: T28027

Synonym: Methotrexate hydrate

KRAS4b-PDEδ stabilizer C19

Cat.No: T32419

Cat.No: T71830

Cat.No: T36944

Target: Nucleoside Antimetabolite/Analog

Anticancer agent 67

Cat.No: T63917

Y27632 HCl hydrate

Cat.No: T69429

Cat.No: T63477

Cat.No: TP2296

Target: Others

(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine

Cat.No: T36610

Tetrachlorohydroquinone

Cat.No: T36507

Cat.No: T62073

S-Acetyl-L-glutathione

Cat.No: T36073

Anticancer agent 137

Cat.No: T79482

Target: PI3K

Cat.No: T75823

Cat.No: T63452

Antitumor agent-37

Cat.No: T64022

Cat.No: T15670

Target: Apoptosis, PKA

2-chloro Palmitic Acid

Cat.No: T36221

C6 Urea Ceramide

Cat.No: T36321

WLSEAGPVVTVRALRGTGSW TFA

Cat.No: T76252L

Cat.No: T36099

Cat.No: T63179

Isovaleryl-L-carnitine (chloride)

Cat.No: T36098

Antioxidant agent-5

Cat.No: T62111

microRNA-21-IN-1

Cat.No: T63879

Antitumor agent-60

Cat.No: T63494

Prostaglandin D2 Ethanolamide

Cat.No: T38389

Synonym: Prostaglandin D2 Ethanolamide

Cat.No: T71285

Cat.No: T35622

Cat.No: T79274

Target: Histone Methyltransferase

Cat.No: T60453

Sitamaquine tosylate

Cat.No: T37469

Cat.No: T36194

Synonym: CAY10726

Ganglioside GD3 Mixture (sodium salt)

Cat.No: T35552

Ochratoxin A-13C20

Cat.No: T35778

Synonym: Ochratoxin A-13C20

Cat.No: T36882

Cat.No: T35762

Cat. No.	Product Name	Target	Signaling Pathways
T5654	Musk ketone	Others	Others
	Musk ketone 可诱导癌细胞生长抑制和凋亡。它增加谷胱甘肽 S-转移酶的活性，因此可能被证明是有用的癌症化学保护剂。
T0983	Penicillamine 青霉胺,d-penicillamin,Dimethyl Cysteine,D-青霉胺,Artamine,D-(-)-Penicillamine	Antibiotic	Microbiology/Virology
	Penicillamine (Artamine) 是一种 penicillin 的代谢降解产物，是一种螯合剂，可作用于威尔逊氏病。
T6S1780	Protosappanin B 原苏木素B,Q-100961,FT-0689654	Apoptosis	Apoptosis
	Protosappanin B (Q-100961) 是从苏木中提取的一种多酚类天然产物，具有抗肿瘤作用。它通过激活 MDM2 依赖性泛素化过程诱导 p53 蛋白降解。它显著提高细胞活力，抑制细胞凋亡并上调生长相关蛋白 43 的表达。
T3410	Momordin Ic 地肤子皂苷Ic,地肤子皂苷 Ic,Momordin 1c	Apoptosis; MAPK; PI3K	Apoptosis; MAPK; PI3K/Akt/mTOR signaling
	Momordin Ic (Momordin 1c) 是山茱萸的主要皂苷成分，通过氧化应激调控线粒体功能障碍诱导细胞凋亡，具有抗癌活性。
T4S1943	Kirenol 奇壬醇,奇任醇,Kirel	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	Kirenol (Kirel) 是分离自 Siegesbeckia orientalis 中的，具有抗氧化、抗炎、抗过敏、抗关节炎活性，可用于缓解疼痛的研究。
T5S1805	5,7-Dihydroxychromone 5,7-Dihydroxy-4H-Chromen-4-One,5,7-二羟基色酮,5,7-二羟基色原酮	Others; Virus Protease; PARP; Caspase; Nrf2	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology; Others; Proteases/Proteasome
	5,7-Dihydroxychromone (5,7-Dihydroxy-4H-Chromen-4-One) 是一种Cudrania tricuspidata 的提取物，通过激活 Nrf2/ARE 信号对 6-OHDA 诱导的氧化应激和细胞凋亡发挥神经保护作用。它抑制 6-OHDA 诱导的 SH-SY5Y 细胞中活化的caspase-3，caspase-9以及切割的PARP 表达。
T5S0053	Coptisine 黄连碱,Coptisin	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Coptisine (Coptisin) 是一种从黄连中分离到的生物碱，是非竞争性的IDO 抑制剂，Ki=为 5.8 μM，IC50=6.3 μM。
T75602	Albanol B
	Albanol B 是一种芳基苯并呋喃衍生物，可从桑葚中分离得到。Albanol B 具有抗阿尔茨海默病、抗菌和抗氧化活性。Albanol B 抑制癌细胞增殖，下调 CDK1表达。Albanol B 还会诱导细胞周期停滞在 G2/M 期，诱导细胞凋亡 (apoptosis)。Albanol B 诱导线粒体 ROS 产生并增加 AKT 和 ERK1/2的磷酸化水平。
TN1694	Gliotoxin	Apoptosis; NF-κB; Wnt/beta-catenin; COX; PKA; Antibacterial; Antifection	Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; Microbiology/Virology; Neuroscience; NF-κB; Stem Cells; Tyrosine Kinase/Adaptors
	Gliotoxin 是一种次生代谢产物，由A. fumigatus 分泌，可以抑制巨噬细胞的吞噬作用和其他免疫细胞的免疫功能。它通过阻止 IκB 降解来抑制诱导型NF-κB 活性，从而诱导宿主细胞凋亡。它可以激活PKA 并增加细胞内 cAMP 浓度，调节肌动蛋白细胞骨架重排以促进A. fumigatus 内化到肺上皮细胞。
T36954	Nemorosone
	Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.1 Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma cells (IC50s = 3.1-6.3 μM), including several drug-resistant clones, but not MRC-5 human embryonic fibroblasts (IC50 = >40 μM).2 It increases DNA fragmentation in LAN-1 cells in a dose-dependent manner, and decreases N-Myc protein levels and phosphorylation of ERK1/2 by MEK1/2. Nem...
T36489	Malformin A
	Malformin A is a cyclopentapeptide fungal metabolite that has been found in A. niger and has diverse biological activities. It is a plant growth regulator that induces malformations in plant structure. Malformin A inhibits replication of tobacco mosaic virus (TMV) in local lesion and leaf-disc assays (IC50s = 19.7 and 45.4 μg/ml, respectively). It is cytotoxic to NCI-H460, MIA PaCa-2, MCF-7, SF-268, and WI-38 cancer cells (IC50s = 70, 50, 100, 70, and 100 nM, respectively), inhibits proliferati...

天然产物

Cat.No: T5654

Target: Others

Cat.No: T0983

Synonym: 青霉胺,d-penicillamin,Dimethyl Cysteine,D-青霉胺,Artamine,D-(-)-Penicillamine

Target: Antibiotic

Protosappanin B

Cat.No: T6S1780

Synonym: 原苏木素B,Q-100961,FT-0689654

Target: Apoptosis

Cat.No: T3410

Synonym: 地肤子皂苷Ic,地肤子皂苷 Ic,Momordin 1c

Target: Apoptosis, MAPK, PI3K

Cat.No: T4S1943

Synonym: 奇壬醇,奇任醇,Kirel

Target: Wnt/beta-catenin

5,7-Dihydroxychromone

Cat.No: T5S1805

Synonym: 5,7-Dihydroxy-4H-Chromen-4-One,5,7-二羟基色酮,5,7-二羟基色原酮

Target: Others, Virus Protease, PARP, Caspase, Nrf2

Cat.No: T5S0053

Synonym: 黄连碱,Coptisin

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T75602

Cat.No: TN1694

Target: Apoptosis, NF-κB, Wnt/beta-catenin, COX, PKA, Antibacterial, Antifection

Cat.No: T36954

Cat.No: T36489

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼