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90

抑制剂 & 化合物

33

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8549	HEPES	Others	Others
	HEPES 是两性离子化学缓冲剂，在 pH 值为 6.8 至 8.2 时为有效的缓冲液，广泛应用于细胞培养。它是溶酶体生物发生的有效诱导剂。
T3478	Ro 67-7476	GluR	Neuroscience
	Ro 67-7476 是mGluR1的正变位调节剂，能增强表达 rat mGluR1a 的 HEK293 细胞中谷氨酸诱导的钙释放，EC50为 60.1 nM。它是 P-ERK1/2 激动剂，可以在外源添加谷氨酸的情况下激活 ERK1/2 磷酸化 (EC50=163.3 nM)。
T2431	ID-8 ID8	DYRK	Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors
	ID-8 是 DYRK 抑制剂，长时间培养能够维持胚胎干细胞的自我更新。
T67854	BAS 00489700	Others	Others
	BAS 00489700是一种N-UTR 相互作用抑制剂。BAS 00489700抑制培养细胞中的病毒复制。
T14181	Alizarin Red S sodium ARS sodium,茜素红钠盐	Others	Others
	Alizarin Red S sodium (ARS sodium) 是一种蒽醌类染料，在检测细胞培养中的钙沉积具有广泛的应用。
T38509	MOPS 3-(N-Morpholino)propanesulfonic acid,3-吗啉丙磺酸,3-Morpholinopropanesulfonic acid,4-Morpholinepropanesulfonic acid,Morpholinopropane sulfonic acid	Others	Others
	MOPS（Morpholinopropane sulfonic acid），作为一种广泛应用的生物缓冲剂，有效调节哺乳动物细胞培养基的pH值。
T64679	Calcium chloride	Others	Others
	Calcium chloride 常用于细胞培养研究，如用作 DMEM 培养基中的钙补充剂，也可以用于制备合成盐水溶液。
TP1125	Insulin(cattle) 牛胰岛素,Insulin from bovine pancreas,胰岛素	IGF-1R	Tyrosine Kinase/Adaptors
	Insulin cattle (Insulin from bovine pancreas) 是一种在胰腺 β 细胞中产生的两链多肽激素，在很多哺乳动物细胞培养体系中用作生长因子。
T41195	FFN 206 dihydrochloride
	FFN 206 dihydrochloride 是一种荧光VMAT2底物，可用于检测细胞培养中的VMAT2亚细胞位置，对DAT 没有显示出可检测的抑制作用。
T9916	Alirocumab	Others	Others
	Alirocumab 是 PCSK9的人单克隆抗体。它能够特异性结合肝脏低密度脂蛋白 (LDL) 受体的下调剂 PCSK9，增强肝脏结合 LDL-胆固醇 (LDL-C) 的能力，降低血液中的 LDL-C 水平。它可用于研究高胆固醇血症。
T40112	PROTAC PD-1/PD-L1 degrader-1 PROTAC PD-1/PD-L1 degrader-1	PROTACs	PROTAC
	PROTAC PD-1/PD-L1 degrader-1, a Cereblon E3 ligand-based compound, is a PD-1/PD-L1 PROTAC that effectively inhibits the interaction between PD-1 and PD-L1 with an IC50 value of 39.2 nM. It successfully restores the suppressed immune response in a co-culture model consisting of Hep3B/OS-8/hPD-L1 cells and CD3 T cells. Additionally, this compound moderately decreases PD-L1 protein levels through a lysosome-dependent mechanism.
T67797	DDG-39 1-(2,3-dideoxy-2-fluoropentofuranosyl)cytosine	Antiviral; HBV; HIV Protease	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	DDG-39 (1-(2,3-dideoxy-2-fluoropentofuranosyl)cytosine)具有抗病毒活性，在细胞培养中具有有效的选择性抗 HIV-1 和HBV 活性。平均抗病毒 IC50为0.61μM。
T33519	MTOB α-keto-γ-Methylthiobutyric acid,4-甲硫基-2-氧丁酸钠,KMBA,MTOB salt,4-methylthio 2-oxobutyric acid	Others	Others
	MTOB (α-keto-γ-Methylthiobutyric acid) 是 c 末端结合蛋白 (CtBP) 的底物，可干扰 CtBP 在细胞培养物和小鼠中的致癌活性。它还积极调节 TCF-4 信号传导，导致癌症干细胞 (CSC) 生长和自我更新。
T22839	HEPES Sodium	Others	Others
	HEPES Sodium salt 是一种非挥发性两性离子化学缓冲剂。HEPES 钠盐在细胞培养中有着广泛的应用。HEPES Sodium salt 在 pH 6.8至8.2时有效。HEPES Sodium salt 也诱导溶酶体的生物发生。
T19820	MOPS sodium salt MOPS-Na,3-(N-morpholino)propanesulfonic acid sodium salt,3-吗啉丙磺酸钠盐,Sodium 3-Morpholinopropanesulfonate,4-Morpholinepropanesulfonic acid, sodium salt	Others	Others
	MOPS sodium salt (MOPS-Na) 在生物学中常用作缓冲剂。其中MOPS 缓冲液能使哺乳动物细胞培养基的 pH 值保持稳定。
T6229	Daclatasvir Daklinza,达卡他韦,EBP 883,达拉他韦,BMS-790052	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Daclatasvir (EBP 883) 是一种高度选择性的 HCV NS5A 抑制剂，EC50 为 9-50 pM，适用于细胞培养中的多种 HCV 复制子基因型和 JFH-1 基因型 2a 感染性病毒。
T37173	MPro Inhibitor 11a
	MProinhibitor 11a is an inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (MPro; IC50= 0.053 μM in a TR-FRET assay).1It reduces viral yield in the culture supernatant of SARS-CoV-2-infected Vero E6 cells (EC50= 0.53 μM). MProinhibitor 11a also reduces viral RNA copy numbers in the same model when used at concentrations ranging from 1.85 to 50 μM. 1.Dai, W., Zhang, B., Jiang, X.-M., et al.Structure-based design of antiviral drug candidates targeting the SARS-...
T40545	MES 2-Morpholinoethanesulphonic acid,4-Morpholineethanesulfonic acid	Others	Others
	MES (2-Morpholinoethanesulphonic acid) (2-Morpholinoethanesulphonic acid) 是一种两性离子缓冲液，在 pH 值 5.5-7.7 范围内有效。MES 作为一种 Good's 缓冲液，广泛应用于植物培养基、试剂溶液和生理实验中调节 pH 值。
T10893	CS-722 Free base	Others	Others
	CS-722 Free base是一种合成的中枢作用肌肉松弛剂，它展现出肌肉松弛效果并抑制脊髓反射。可能通过限制钠和钙流动，从而在海马培养物中减少自发的抑制性和兴奋性突触后电流。
T17197	UCL 2077
	UCL 2077 是癫痫相关 KCNQ 通道的亚型选择性阻滞剂，也是一种选择性慢后超极化通道阻滞剂，在培养的海马神经元中 IC50 为 500 nM，对 Ca2+ 通道、动作电位、输入电阻的影响小，以及超极化后的介质。
TP1895L1	KYL acetate(676657-00-4 free base)	Ephrin Receptor	Tyrosine Kinase/Adaptors
	KYL acetate(676657-00-4 free base) 是EphA4受体酪氨酸激酶抑制剂（Kd = 0.8 μM）；抑制 EphA4-EphrinA5 相互作用 (IC50 = 6.34 μM)。防止 AβO 诱导的突触损伤、树突棘丢失并防止海马 CA3-CA1 传输中 LTP 的阻断。在细胞培养基中表现出较长的半衰期（在 PC3 和 C2C12 培养基中分别为 8 和 12 小时）。它有神经保护作用。
T4503	Talniflumate Somalgen,他尼氟酯	Chloride channel; COX; N-Acetylglucosaminyltransferase; Anion Exchanger	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Talniflumate (Somalgen) 是一种钙激活氯离子通道 (hCLCA1/mCLCA3) 阻滞剂，可减少动物模型和细胞培养中的粘蛋白合成和释放。它通过抑制环氧合酶，并抑制 Cl-/HCO3- 交换活性，具有抗炎作用。它还增加了远端肠梗阻综合征囊性纤维化小鼠模型的存活率。
T60013	GA-017	Others	Others
	GA-017是一种有效的选择性 LATS1和 LATS2(大型肿瘤抑制激酶 1/2) 抑制剂，其 IC50值分别为 4.10 和 3.92 nM。GA-017 是细胞增殖的激活剂。GA-017 促进 YAP/TAZ 激活和核转位。GA-017 在 3D 培养条件下促进细胞生长。GA-017 增强小鼠肠道类器官的离体形成。
T7042	1,5-Isoquinolinediol	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	1,5-Isoquinolinediol 是一种多聚（ADP-核糖）合成酶抑制剂，对PARP1的IC50值为 0.39 µM。它用于研究 PARP1 在 DNA 修复和氧化应激诱导的细胞死亡中的作用。
T12610L	3-Hydroxy Midostaurin CGP52421	FLT	Angiogenesis; Tyrosine Kinase/Adaptors
	3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412[1].
T20130	Elastatinal BRN0873543,BRN 0873543,BRN-0873543
	Elastatinal is an elastase inhibitor. It is found in culture filtrates of various species of actinomyces.
T1720L	Amfenac NSC309467,NSC-309467,NSC 309467
	Amfenac promotes apoptosis in ARPE-19 cell culture.
T32749	Liga 20 Liga-20,Liga20
	Liga 20 is a semisynthetic GM1 ganglioside with N-dichloroacetylsphingosine that protecting neurons in culture against glutamate toxicity.
T35320	Zygosporin D Deactylzygosporin A
	Zygosporin D is one of the cytochalasins was isolated from the culture filtrate of the fungus Metarrhizium anisopliae.
T25038	Aldgamycin E
	Aldgamycin E is a neutral macrolide antibiotic agent from culture filtrates of Streptomyces lavendulae. Methanolysis produces methyl algarosides A & B.
T26416	A 33853 A-33853,A33853
	A 33853 is an antibiotic isolated from culture broth of Streptomyces sp.
T27394	Furalazine Furalazinum,Panfuran,Nifuralazinum,NFT
	Furalazine is an antimicrobial agent. Furalazine was more effective in reducing the duration of positive stool culture than chloramphenicol. It may be potentially used in the treatment of cholera.
T31790	FFN200 dihydrochloride FFN200 HCl,FFN200,FFN 200,FFN-200
	FFN200 is a vesicular monoamine transporter 2 (VMAT2) substrate that selectively traces monoamine exocytosis in both neuronal cell culture and brain tissue.
T24366	L 870810 L-870,810,L870810,L 870,810,L870,810,L-870810
	L 870810 is a small-molecule inhibitor of HIV-1 integrase with potent antiviral activity in cell culture and good pharmacokinetic properties.
T28476	Pyrroxamycin LL-F42248-alpha,Dioxapyrrolomycin,AL-R2081
	Pyrroxamycin is a new antibiotic. Pyrroxamycin was isolated from the culture broth of Streptomyces sp. S46506. Pyrroxamycin is active against Gram-positive bacteria and dermatophytes.
T24432	MB21 MB-21,MB 21
	MB21 is a dengue type 2 protease inhibitor that acts by inhibiting each one of the four serotypes of dengue viruses in infected cells in culture.
T31784	Ferric citrate JTT 751
	Ferric citrate as a source of iron used in cell culture applications can provide iron with a less toxic form compared to free iron salts.
T71073	Tan 931
	Tan 931 is a nonsteroidal aromatase inhibitor that was first isolated from the culture filtrate of a soil isolate fungus, No. 8974
T11795	L-4-Oxalysine hydrochloride	Others	Others
	L-4-Oxalysine hydrochloride has shown antitumor activities, is a natural product isolated from the culture media of Streptomyces roseovirdofuscus in China.
T70878	P516-0475
	P516-0475 is a novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO. This compound induces quorum sensing by stabilizing SHP pheromones in culture.
T69782	GS-9822
	GS-9822 is a novel LEDGIN, an inhibitor that targets the binding pocket of LEDGF/p75 which is a cellular cofactor that substantially contributes to HIV integration site selection, displaying a block-and-lock phenotype in cell culture.
T28311	PD 116152 PD116,152,PD 116,152,PD116152,PD-116,152,PD-116152
	PD 116152 is a highly substituted phenazine with antitumor activity isolated from the culture broth of a Streptomyces sp. The antitumor activity versus murine P388 leukemia is T/C 149. PD 116152 is selectively active versus the bacterium Streptococcus pne
T25849	Naftoxate Naftoxatum,Naftoxato
	Naftoxate is an antimicotic. It is effective against both gram-positive and gram-negative bacteria as well as yeasts and other fungi in plant cell culture.
T36751	Dihydroxy Melphalan
	Dihydroxy melphalan is an inactive degradation product of melphalan . It is formed by the hydrolysis of melphalan via the intermediate monohydroxy melphalan in aqueous solutions, including cell culture medium and human plasma.
T36436	Spergualin trihydrochloride
	Spergualin trihydrochloride is a natural product that first identified as an antibiotic from culture filtrates of Bacillus laterosporus BMG162-aF2[1]. Spergualin trihydrochloride derivatives likely acts as Hsp70 modulators[1]. [1]. Srikanth Patury, et al. Pharmacological Targeting of the Hsp70 Chaperone. Curr Top Med Chem. 2009;9(15):1337-51.
T38823	sulfo-DGN462 sodium sulfo-DGN462 sodium
	Sulfo-DGN462 sodium undergoes degradation to DGN462 when subjected to culture medium and plasma. DGN462, a highly effective DNA-alkylating agent, exhibits anti-tumor properties that are particularly active against acute myeloid leukemia (AML).
T71487	WRR-483
	WRR-483, an analogue of K-11777, is a potent and selective cysteine protease inhibitor with trypanocidal activity in cell culture and animal model with comparable efficacy to K11777. WRR-483 demonstrates good potency against cruzain with sensitivity to pH conditions and high efficacy in the cell culture assay. Furthermore, WRR-483 also eradicates parasite infection in a mouse model of acute Chagas' disease. WRR-483 binds covalently to the active site cysteine of the protease in a similar manner...
T65782	HEPBS	Others	Others
	HEPBS 是一种两性离子生物缓冲剂，其 pH 范围在7.6到9.0之间。HEPBS 可用于细胞的培养和其他细胞实验。
T27367	FR 900490 BMY 28700,FR-900490,FR900490
	FR 900490 is an immunoactive substance produced by a fungus Discosia sp. F-11809. In vitro FR-900490 restores the colony forming units in culture (cfu-c) in bone marrow cells, which were suppressed by immunosuppressive factor obtained from the serum of sa
T71930	aPKC-I
	aPKC-I is an inhibitor of atypical protein kinase C (aPKC ) which inhibits both PKCζ and PKCι with high specificity and prevents VEGF-induced endothelial permeability in cell culture and in vivo, thereby blocking ischemia-reperfusion (IR)-induced permeability.

化合物

Cat.No: T8549

Target: Others

Cat.No: T3478

Target: GluR

Cat.No: T2431

Synonym: ID8

Target: DYRK

Cat.No: T67854

Target: Others

Alizarin Red S sodium

Cat.No: T14181

Synonym: ARS sodium,茜素红钠盐

Target: Others

Cat.No: T38509

Synonym: 3-(N-Morpholino)propanesulfonic acid,3-吗啉丙磺酸,3-Morpholinopropanesulfonic acid,4-Morpholinepropanesulfonic acid,Morpholinopropane sulfonic acid

Target: Others

Calcium chloride

Cat.No: T64679

Target: Others

Insulin(cattle)

Cat.No: TP1125

Synonym: 牛胰岛素,Insulin from bovine pancreas,胰岛素

Target: IGF-1R

FFN 206 dihydrochloride

Cat.No: T41195

Cat.No: T9916

Target: Others

PROTAC PD-1/PD-L1 degrader-1

Cat.No: T40112

Synonym: PROTAC PD-1/PD-L1 degrader-1

Target: PROTACs

Cat.No: T67797

Synonym: 1-(2,3-dideoxy-2-fluoropentofuranosyl)cytosine

Target: Antiviral, HBV, HIV Protease

Cat.No: T33519

Synonym: α-keto-γ-Methylthiobutyric acid,4-甲硫基-2-氧丁酸钠,KMBA,MTOB salt,4-methylthio 2-oxobutyric acid

Target: Others

Cat.No: T22839

Target: Others

MOPS sodium salt

Cat.No: T19820

Synonym: MOPS-Na,3-(N-morpholino)propanesulfonic acid sodium salt,3-吗啉丙磺酸钠盐,Sodium 3-Morpholinopropanesulfonate,4-Morpholinepropanesulfonic acid, sodium salt

Target: Others

Cat.No: T6229

Synonym: Daklinza,达卡他韦,EBP 883,达拉他韦,BMS-790052

Target: HCV Protease

MPro Inhibitor 11a

Cat.No: T37173

Cat.No: T40545

Synonym: 2-Morpholinoethanesulphonic acid,4-Morpholineethanesulfonic acid

Target: Others

CS-722 Free base

Cat.No: T10893

Target: Others

Cat.No: T17197

KYL acetate(676657-00-4 free base)

Cat.No: TP1895L1

Target: Ephrin Receptor

Cat.No: T4503

Synonym: Somalgen,他尼氟酯

Target: Chloride channel, COX, N-Acetylglucosaminyltransferase, Anion Exchanger

Cat.No: T60013

Target: Others

1,5-Isoquinolinediol

Cat.No: T7042

Target: PARP

3-Hydroxy Midostaurin

Cat.No: T12610L

Synonym: CGP52421

Target: FLT

Cat.No: T20130

Synonym: BRN0873543,BRN 0873543,BRN-0873543

Cat.No: T1720L

Synonym: NSC309467,NSC-309467,NSC 309467

Cat.No: T32749

Synonym: Liga-20,Liga20

Cat.No: T35320

Synonym: Deactylzygosporin A

Cat.No: T25038

Cat.No: T26416

Synonym: A-33853,A33853

Cat.No: T27394

Synonym: Furalazinum,Panfuran,Nifuralazinum,NFT

FFN200 dihydrochloride

Cat.No: T31790

Synonym: FFN200 HCl,FFN200,FFN 200,FFN-200

Cat.No: T24366

Synonym: L-870,810,L870810,L 870,810,L870,810,L-870810

Cat.No: T28476

Synonym: LL-F42248-alpha,Dioxapyrrolomycin,AL-R2081

Cat.No: T24432

Synonym: MB-21,MB 21

Cat.No: T31784

Synonym: JTT 751

Cat.No: T71073

L-4-Oxalysine hydrochloride

Cat.No: T11795

Target: Others

Cat.No: T70878

Cat.No: T69782

Cat.No: T28311

Synonym: PD116,152,PD 116,152,PD116152,PD-116,152,PD-116152

Cat.No: T25849

Synonym: Naftoxatum,Naftoxato

Dihydroxy Melphalan

Cat.No: T36751

Spergualin trihydrochloride

Cat.No: T36436

sulfo-DGN462 sodium

Cat.No: T38823

Synonym: sulfo-DGN462 sodium

Cat.No: T71487

Cat.No: T65782

Target: Others

Cat.No: T27367

Synonym: BMY 28700,FR-900490,FR900490

Cat.No: T71930

Cat. No.	Product Name	Target	Signaling Pathways
T2A2476	L-Hydroxyproline 羟脯氨酸,trans-4-Hydroxy-L-proline,L-Hydroxyprolin,Trans-4-Hydroxyproline	Endogenous Metabolite	Metabolism
	L-Hydroxyproline (L-Hydroxyprolin) 是羟脯氨酸的异构体之一，是药物生产中有用的手性结构单元。
T4S1521	1,4-Dicaffeoylquinic acid 1,4-二咖啡酰奎宁酸,洋蓟素	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	1,4-Dicaffeoylquinic acid 是一种苯丙素类物质，从苍耳子中获得，可以减少 LPS 诱导的 TNF-α 的生成，具有抗炎活性。
T39007	3,4-Dimethoxybenzamide	Others	Others
	3,4-Dimethoxybenzamide 是分离自Streptoverticillium morookaense 固体培养物的酰胺。它是制备盐酸伊托必利的起始原料。
T4915	β-Glycerophosphate disodium salt hydrate	Phosphatase; Endogenous Metabolite	Metabolism
	β-Glycerophosphate disodium salt hydrate 是一种磷酸酶抑制剂，是内源性代谢产物的一种。
T39887	(S)-3-(4-Hydroxyphenyl)lactic acid (S)-3-(4-羟苯基)乳酸,(S)-3-(4-Hydroxyphenyl)lactic acid,(S)-3-(4-Hydroxyphenyl)-2-hydroxypropionic acid	Others	Others
	(S)-3-(4-Hydroxyphenyl)-2-hydroxypropionic acid ((S)-3-(4-Hydroxyphenyl)lactic acid) 是分离自间肠隐球菌培养基的代谢物，具有高的 DPPH 清除自由基活性和抗氧化活性。
T60789	L-Cystine dihydrochloride
	L-Cystine dihydrochloride 是合成谷胱甘肽 (GSH) 的含硫前体。L-Cystine dihydrochloride 的稳态对谷胱甘肽的功能很重要。L-Cystine dihydrochloride 可用作细胞培养组分。
T20945	2,4-D Hedonal,Macondray,2,4-D acid,Chloroxone,2,4-二氯苯氧乙酸	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	2,4-Dichlorophenoxyacetic acid (Hedonal) 是一种合成生长素，用作植物生长调节剂，也用作植物细胞培养基中的补充剂。它是除草剂中的一种活性成分，用于破坏肌动蛋白细胞骨架，以控制根系伸长和细胞生成。
T20879	Tacrolimus monohydrate FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,他克莫司一水合物,FK 506	Phosphatase; Others; Antibacterial; Antibiotic; Autophagy	Autophagy; Metabolism; Microbiology/Virology; Others
	Tacrolimus monohydrate (LCP-Tacro) 是大环内酯类化合物，它与 FK506 结合蛋白 (FKBP) 结合形成复合物并抑制钙调神经磷酸酶，从而抑制 T 淋巴细胞信号转导和 IL-2 转录。具有强免疫抑制特性。
T3889	Platycodin D	Prostaglandin Receptor; AMPK	Chromatin/Epigenetic; GPCR/G Protein; Immunology/Inflammation; PI3K/Akt/mTOR signaling
	Platycodin D 是从桔梗中分离得到的一种皂苷类天然产物，是AMPKα的激活剂，具有抗肥胖活性。它可刺激 TNF-α 合成或抑制 TNF-α mRNA 的降解。
T4918	DL-Glyceraldehyde Glyceric aldehyde,DL-甘油醛晶体	Reductase	Endocrinology/Hormones; Metabolism
	DL-Glyceraldehyde (Glyceric aldehyde) 是由酶甘油醛脱氢酶的作用产生的，该酶使用 NADP 作为辅因子将甘油转化为甘油醛。它是一种高活性化合物，可以修饰和交联蛋白质。
T36585	Isodeoxycholic Acid isoDCA	Chloride channel; Antibacterial	Membrane transporter/Ion channel; Microbiology/Virology
	Isodeoxycholic Acid 是一种胆汁酸，由肠道细菌通过脱氧胆酸的表聚作用形成。Isodeoxycholic acid 的临界胶束浓度高于二氯苯甲醚，这表明它的去污活性降低了，而且在抑制七种肠道共生细菌生长方面的活性低于二氯苯甲醚。Isodeoxycholic Acid（0.1%）能抑制几种艰难梭菌菌株在牛磺胆酸诱导下的孢子萌发，并能降低艰难梭菌培养上清对 Vero 细胞的细胞毒性。在高脂饮食诱发肥胖的大鼠模型中，血浆中的Isodeoxycholic acid 水平比正常饮食的大鼠低。
T38579	Rutarensin
	Rutarensin is a phenolic compound found in Ruta chalepensis cell culture.
TN6688	Cyclo(Ala-Tyr)
	Cyclo(Val-Tyr) is a product from the culture of Pseudomonas putida.
T20541	Phosphoramidon
	Phosphoramidon is a membrane metallo-endopeptidase & endothelin-converting enzyme inhibitor and thermolysin inhibitor, which is obtained from culture filtrate of Streptomyces tanashiensis.
TN4085	Fupenzic acid	Others	Others
	Fupenzic acid shows a significant decrease in intracellular melanin content in B16-F10 cells, and in culture media melanin.
T20628	Kifunensine
	Kifunensine, a potent and selective inhibitor of class I α-mannosidases, may serve as a key inhibitor of glycoprotein biosynthesis. Its inhibitory effect may lead to high mannose glycoproteins in cell culture.
TN3547	Bullatantriol	Antifection	Microbiology/Virology
	Bullatantriol has a stimulative effect on significantly proliferation and differentiation of culture osteoblasts. It may have weak antibacterial activities.
TN4328	Isosativenediol	Others	Others
	Isosativenediol is a natural product from the culture filtrates of a Bipolaris species pathogenic to Johnson grass.
TN4716	Oplodiol	Influenza Virus	Microbiology/Virology
	Oplodiol exhibits noteworthy anti-plasmodial activity against Plasmodium falciparum strains. Oplodiol has a stimulative effect on significantly proliferation and differentiation of culture osteoblasts; it also shows moderate cytotoxic effects on the human
TN2841	2alpha,9alpha,11-Trihydroxy-6-oxodrim-7-ene	Others	Others
	2alpha,9alpha,11-Trihydroxy-6-oxodrim-7-ene is a natural product from the culture medium of the marine-derived fungus Aspergillus insuetus (OY-207).
T81735	Mycestericin C
	Mycestericin C, 分离自 Mycelia sterilia ATCC 20349 的培养液, 能在小鼠同种异体混合淋巴细胞反应中抑制淋巴细胞的增殖。
T75534	Maniwamycin E
	Maniwamycin E，一种耐热链霉菌培养提取物中分离得到的马尼瓦霉素衍生物，展示了对SARS-CoV-2和H1N1流感病毒的抗病毒活性。
TN2792	2-Oxopomolic acid
	2-Oxopomolic acid shows cytotoxic activity, it shows a significant decrease in intracellular melanin content in B16-F10 cells, and in culture media melanin. 2-Oxopomolic acid shows radical-scavenging activities similar to that of the reference antioxidant
T36295	Echistatin TFA
	Echistatin TFA, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorption in culture. Echistatin is a potent antagonist of αIIbβ3, αvβ3 and α5β1[1][2][3][4]. [1]. J Musial, et al. Inhibition of platelet adhesion to surfaces of extracorporeal circuits by disintegrins. RGD-containing peptides from viper venoms. Circulation. 1990 Jul;82(1):261-73.[2]. ...
T81016	Terrelumamide A
	Terrelumamide A是一种带有lumazine结构的肽类化合物，从海洋真菌Aspergillus terreus的培养物中提取分离得到。该化合物因增强胰岛素敏感性而显示出药理作用，并在DNA序列识别方面具有潜在应用价值。
T81676	NG-012
	NG-012为一种神经生长因子(NGF)增强剂，来源于Penicillium verruculosum F-4542的培养液。该化合物能在大鼠嗜铬细胞瘤细胞系(PC12)中提升NGF引导的神经突生长效应。
T70355	Flutimide
	Flutimide是一种针对流感病毒核酸内切酶的选择性抑制剂，具有3 μM的IC50值，表现出细胞培养中的抗病毒活性，适用于流感等急性传染性呼吸道疾病的研究。
T74196	Inophyllum B
	Inophyllum B ((+)-Inophyllum B) 是一种有效的HIV 逆转录酶 (Reverse Transcriptase) 抑制剂，IC50为 38 nM。Inophyllum B 在体外细胞培养中抑制HIV-1(IC50=1.4 μM)。Inophyllum B 可从非洲大蜗牛Achatina fulica 的丙酮提取物中分离得到。
TN3753	Dalbergioidin	Tyrosinase; ROS; Akt; PI3K; TGF-beta/Smad	Cytoskeletal Signaling; Immunology/Inflammation; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
	Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces bikiniensis that has commonly been used as an indicator organism. Dalbergioidin protects MC3T3-E1 osteoblastic cells against H2O2-induced cell damage through activation of the PI3K/AKT/SMAD1 pathway, suggests that it may be useful in bone metabolism diseases, particularly osteoporosis. Dalbergioidin also ameliorates doxorubicin-induced ...
TN2533	1-Hydroxy-2,3,4,7-tetramethoxyxanthone	5-HT Receptor	GPCR/G Protein; Neuroscience
	1-Hydroxy-2,3,4,7-tetramethoxy-xanthone has vasodilatory action, it can cause vasodilation in the coronary artery pre-contracted with 1uM 5-hydroxytryptamine (5-HT), with the EC 50 value of 6.6±1.4 uM. 1-Hydroxy-2,3,4,7-tetramethoxyxanthone can effectivel
TN2534	1-Hydroxy-2,3,5-trimethoxyxanthone	IκB/IKK; Calcium Channel; NOS; 5-HT Receptor; COX	GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB
	1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independent mechanism by inhibiting Ca(2+) influx through L-type voltage-operated Ca(2+) channels; a minor contribution to the effects of HM-1 may be related to inhibition of the protein kinase C-mediated release of intracellular Ca(2+) stores. HM-1,at the concentration of 1 ug/mL, can effectively inhibit the osteoclast differentiation in a co-c...
T81201	Sartorypyrone B
	Sartorypyrone B为Chevalone C的2β-乙酰氧基衍生物，由海绵源真菌Neosartorya tsunodae(KUFC 9213)的培养物中乙酸乙酯提取得到。该化合物对MCF-7、NCI-H460和A375-C5细胞系展示出较强的生长抑制活性，GI50s值分别为17.8、20.5和25.0 μM，显示其在乳腺癌、非小细胞肺癌和黑色素瘤研究中的应用潜力。
T15637	K-252b	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	K-252b is an indolocarbazole isolated from the actinomycete Nocardiopsis and is a PKC inhibitor. K-252b can be used to inhibit extracellular kinases of cells in culture because it can’t pass through the cell membrane freely.

天然产物

L-Hydroxyproline

Cat.No: T2A2476

Synonym: 羟脯氨酸,trans-4-Hydroxy-L-proline,L-Hydroxyprolin,Trans-4-Hydroxyproline

Target: Endogenous Metabolite

1,4-Dicaffeoylquinic acid

Cat.No: T4S1521

Synonym: 1,4-二咖啡酰奎宁酸,洋蓟素

Target: HIV Protease

3,4-Dimethoxybenzamide

Cat.No: T39007

Target: Others

β-Glycerophosphate disodium salt hydrate

Cat.No: T4915

Target: Phosphatase, Endogenous Metabolite

(S)-3-(4-Hydroxyphenyl)lactic acid

Cat.No: T39887

Synonym: (S)-3-(4-羟苯基)乳酸,(S)-3-(4-Hydroxyphenyl)lactic acid,(S)-3-(4-Hydroxyphenyl)-2-hydroxypropionic acid

Target: Others

L-Cystine dihydrochloride

Cat.No: T60789

Cat.No: T20945

Synonym: Hedonal,Macondray,2,4-D acid,Chloroxone,2,4-二氯苯氧乙酸

Target: DNA/RNA Synthesis

Tacrolimus monohydrate

Cat.No: T20879

Synonym: FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,他克莫司一水合物,FK 506

Target: Phosphatase, Others, Antibacterial, Antibiotic, Autophagy

Cat.No: T3889

Target: Prostaglandin Receptor, AMPK

DL-Glyceraldehyde

Cat.No: T4918

Synonym: Glyceric aldehyde,DL-甘油醛晶体

Target: Reductase

Isodeoxycholic Acid

Cat.No: T36585

Synonym: isoDCA

Target: Chloride channel, Antibacterial

Cat.No: T38579

Cat.No: TN6688

Cat.No: T20541

Cat.No: TN4085

Target: Others

Cat.No: T20628

Cat.No: TN3547

Target: Antifection

Isosativenediol

Cat.No: TN4328

Target: Others

Cat.No: TN4716

Target: Influenza Virus

2alpha,9alpha,11-Trihydroxy-6-oxodrim-7-ene

Cat.No: TN2841

Target: Others

Cat.No: T81735

Cat.No: T75534

2-Oxopomolic acid

Cat.No: TN2792

Cat.No: T36295

Terrelumamide A

Cat.No: T81016

Cat.No: T81676

Cat.No: T70355

Cat.No: T74196

Cat.No: TN3753

Target: Tyrosinase, ROS, Akt, PI3K, TGF-beta/Smad

1-Hydroxy-2,3,4,7-tetramethoxyxanthone

Cat.No: TN2533

Target: 5-HT Receptor

1-Hydroxy-2,3,5-trimethoxyxanthone

Cat.No: TN2534

Target: IκB/IKK, Calcium Channel, NOS, 5-HT Receptor, COX

Sartorypyrone B

Cat.No: T81201

Cat.No: T15637

Target: PKC

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