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79

抑制剂 & 化合物

13

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T19235	CHAPS	Others	Others
	CHAPS 是一种两性离子洗涤剂，是一种 Cholic acid 的衍生物，可溶解膜蛋白。它用于稳定各种蛋白质-DNA 复合物，并可以保留溶液中蛋白质的生化活性。
T31479	Diisopropyl xanthogen disulfide NSC1339,NSC 1339,Isopropylxanthic disulfide,二硫化二异丙基黄原酸酯,NSC-1339	Others	Others
	Diisopropyl xanthogen disulfide (NSC-1339) 可用于合成与钼辅因子相关的金属络合物的前配体。
T36411	9-Ethylguanine	Others	Others
	9-Ethylguanine 是一种模型核碱基，常用于研究 DNA 与有机金属配合物的相互作用。
T22402	Potassium thioacetate	Others	Others
	Potassium thioacetate 它已被用于合成聚合物、杂环、纳米颗粒、过渡金属配体、生物活性化合物和大分子包合物。
T7086	Tris(benzyltriazolylmethyl)amine 三[(1-苄基-1H-1,2,3-三唑-4-基)甲基]胺,TBTA	Others	Others
	Tris(benzyltriazolylmethyl)amine (TBTA) 是一种能作为生化工具的配体，可用于标记蛋白质和酶。
T20346	Salicylaldoxime	Others	Others
	Salicylaldoxime 是一种螯合剂，有时用于分析含有过渡金属离子的样品，它通常与过渡金属离子形成色彩鲜艳的配位络合物。
T0664	Nicotinic acid hydrazide	Others	Others
	Nicotinic acid hydrazide（NAH）是烟酸的酰肼衍生物，一种杂环有机物，是过氧化物酶抑制剂，可以形成具有较强生物活性的固态金属配合物。
T16348	NS5806 NS-5806	Potassium Channel	Membrane transporter/Ion channel
	NS5806 是钾电流的激活剂，可增加 KV4.3/KChIP2峰值电流幅度，EC50值为 5.3 μM。它会在包含 KChIP2 的通道复合体中降低 KV4.2 和 KV4.3 电流衰减。
T3317	SZL P1-41	Apoptosis; Others; E1/E2/E3 Enzyme	Apoptosis; Others; Ubiquitination
	SZL P1-41 是 Skp2 抑制剂，可以阻止 Skp2-Skp1 复合物的组装。它选择性地抑制 Skp2 SCF E3 连接酶活性，还在体内外抑制 Skp2 介导的 p27 和 Akt 泛素化。它通过触发细胞衰老和抑制糖酵解来抑制 Y 细胞和 Y 干细胞的存活，有抗肿瘤作用。
T22922	Lenalidomide hemihydrate	TNF; Ligand for E3 Ligase; Molecular Glues	Apoptosis; PROTAC
	Lenalidomide hemihydrate 是 Thalidomide 的衍生物，也是具有口服活性免疫调节剂，以分子胶的方式作用。它是泛素 E3 连接酶 cereblon 的配体，通过 CRBN-CRL4 泛素连接酶对两种淋巴转录因子 IKZF1 和 IKZF3 进行选择性泛素化和降解。
T14778	BRD6989	IL Receptor; CDK; Interleukin	Cell Cycle/Checkpoint; Immunology/Inflammation
	BRD6989 是天然产物皮质抑素 A 的类似物，可抑制CDK8并上调IL-10，抑制重组 CDK8 或 CDK19 复合物的激酶活性。它选择性结合 CDK8 复合物，IC50约为 200 nM。
T3940	CID5721353 BCL6 inhibitor	Apoptosis; BCL	Apoptosis
	CID5721353 (BCL6 inhibitor) 是一种 B 细胞淋巴瘤 6 抑制剂，IC50为 212 μM，Ki 值为 147 μM。它可在体内外破坏 BCL6/辅助阻遏物复合物，并显示与 BTB 沟内的关键位点结合。
T9679	N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)pyrazine-2-carboxamide	Antibacterial	Microbiology/Virology
	N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)pyrazine-2-carboxamide 对细菌 DNA 解旋酶、核酸酶或解旋酶-核酸酶复合物具有抑制作用，例如例如，一种或多种选自 RecBCD 和AddAB 酶家族的酶。
T2410	Nedaplatin 奈达铂,NSC 375101D	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Nedaplatin (NSC-375101D) 是顺铂的衍生物，是肿瘤集落形成单位的 DNA 损伤剂，IC50为94 μM。
T61111	UCB-5307	TNF	Apoptosis
	UCB-5307 是一种小分子化合物，可在体外抑制 TNFR1 信号转导和下游功能。人 TNFα 的 KD 为 9 nM。 TNF 直接通过缓慢的结合动力学结合，KD = 6 nM。 UCB-5307 可以通过预制的 hTNF/hTNFR1 复合物。
T8796	CAN508	CDK	Cell Cycle/Checkpoint
	CAN508 是一种有效的 ATP 竞争性 CDK9/cyclin T1 抑制剂，IC50 为 0.35 μM。它还是 Cdk2-cyclin E 对 ATP 的竞争性抑制剂，Ki 和 IC50 值分别为 13.3 和 20 µM。它对 CDK9/cyclin T 的选择性是其他 CDK/cyclin 复合物的 38 倍，有抗肿瘤活性。
T38651	Lauryl maltose neopentyl glycol LMNG
	Lauryl maltose neopentyl glycol (LMNG) 是一种能溶解和稳定膜蛋白的洗涤剂。Lauryl maltose neopentyl glycol 能从膜上提取完整的膜蛋白，从而改善G 蛋白偶联受体和呼吸系统复合物等膜蛋白的稳定性。Lauryl maltose neopentyl glycol 具有增溶作用。
T68002	Naroparcil	Thrombin	Proteases/Proteasome
	Naroparcil 是一种可口服的硫代苷类化合物，是一种 4-甲基伞形 β-D-木糖苷类似物，在静脉血栓形成（颈静脉）的Wessler淤滞模型中显示出抗血栓形成作用。Naroparcil 增强了凝血酶/肝素辅因子II复合物的形成，诱导了处理兔血浆中硫酸皮肤素样物质的出现，但减少了与（125I）-人α-凝血酶孵育的血浆中的凝血酶/抗凝血酶III复合物的形成。
T24654	PPT
	PPT is a modulator of water-heme interactions of CYP2C9d and CYP125A1 in low-spin P450 complexes.
T31035	CP 85339 CP-85339,CP85339,CP-85,339
	CP 85339 is an aspartic acid protease inhibitor for X-ray analysis of peptide-renin complexes.
T21070	Manganese carbonyl Dimanganese decacarbonyl,Decacarbonyldimanganese
	Manganese carbonyl is used in organometallic reactions to prepare polynuclear selenium manganese carbonyl cluster complexes.
T30763	CB 3731 CB3731,CB-3731
	CB 3731 is used in fluorine-19 nuclear magnetic resonance studies of binary and ternary complexes of thymidylate synthase.
T10605	BRD-K98645985	Others	Others
	BRD-K98645985 is a BAF transcriptional repression inhibitor (EC50: ~2.37 µM). It binds ARID1A-specific BAF complexes, potently reverses HIV-1 latency and prevents nucleosomal positioning.
T70862	AMPK Activator SC4
	SC4 is a potent, direct AMPK activator. SC4 preferentially activates α2 complexes and stimulates skeletal muscle glucose uptake.
T26004	Pyrithione sodium SQ-3277,SQ3277,SQ 3277
	Pyrithione sodium is isolated from cephalosporin molecule; some metal complexes of this have fumarate reductase inhibitory activity and may be useful against trypanosomes.
T39366	Corixetan
	Corixetan is a potent thorium chelator that effectively forms stable complexes with Th-227 in vivo.
T12209	Netropsin dihydrochloride	Others	Others
	Netropsin dihydrochloride is a small-molecule MGB (minor-groove binder), inhibits the catalytic activity of isolated topoisomerase and interferes with the stabilization of the cleavable complexes of topoisomerase II and I in nuclei.
T34053	Phthalocyanine
	Phthalocyanine is an intensely blue-green-coloured aromatic macrocyclic compound that is widely used in dyeing. Phthalocyanine can be used as an agent for Photodynamic Therapy and Imaging. Phthalocyanines form coordination complexes with most elements of
T23874	CESTRIN
	CESTRIN is a cellulose synthase trafficking probe that acts by inhibiting cellulose deposition and interferes with the trafficking of cellulose synthase complexes and their associated proteins KORRIGAN1 and POM2/CSI1.
T69456	Melagatran monohydrate
	Melagatran monohydrate is a thrombin inhibitor. Melagatran prevents tissue factor expression in human platelet-monocyte heterotypic complexes. Melagatran reduces advanced atherosclerotic lesion size and may promote plaque stability in apolipoprotein E-deficient mice.
T18619	Bis-PEG1-C-PEG1-CH2COOH PROTAC Linker 26	Others	Others
	Bis-PEG1-C-PEG1-CH2COOH (PROTAC Linker 26) is a PEG-based linker suitable for the synthesis of PROTACs, compound complexes that selectively degrade target proteins[1].
TP1589	EGFRvIII peptide (PEPvIII) EGFRvIII peptide PEPvIII
	PEPvIII, a peptide sequence from EGFRvIII, was designed to represent a target of glioma and is presented by MHC I/II complexes.
T14656	Bis-propargyl-PEG3	Others	Others
	Bis-propargyl-PEG3 is a PEG-based PROTAC linker utilized for the synthesis of PROTACs. It is also employed in the synthesis of antiplasmodial zinc-dipicolylamine (ZnDPA) complexes[1] [2].
T71813	Cardanol diene
	Cardanol diene is a phenol found in cashew nut shell liquid that inhibits tyrosinase with an IC50 value of 52.5 μM in vitro. Cardanol diene is also used to synthesize cardanol-metal complexes that inhibit uropathogenic E. coli biofilm formation.
T74246	Transfectam
	Transfectam为一种阳离子脂质，能与DNA形成复合物，从而高效地将基因转入多种真核细胞。
T71385	Aroplatin
	Aroplatin is a synthetic liposomal formulation of bis-neodecanoate diaminocyclohexane platinum (NDDP), a third-generation platinum complex analogue of cisplatin, with potential antineoplastic activity. After displacement of the 2 long-chain aliphatic leaving groups (neodecanoic acid), platinum diaminocyclohexane (DACH) complexes become highly reactive and alkylate macromolecules, forming both inter- and intra-strand DNA crosslinks and inhibiting DNA synthesis, which results in tumor cell cytotox...
T36700	CKD 602
	Topoisomerase I inhibitor. Forms stable DNA-topoisomerase complexes during DNA replication and induces cell cycle arrest in the G2/M phase. Inhibits growth of a range of cancer cell lines in vitro, as well as of ovarian and leukemia tumors in vivo.
T27687	JNJ525 JNJ 525,JNJ-525
	JNJ525 is an inhibitor of TNFα. JNJ525 inhibits protein function via an aggregation-based mechanism. JNJ525 prevents the formation of TNFα complexes with TNFR1 and TNFR2, the apparent IC50 values for the inhibition of complex formation are 1.2 ± 0.2 μM an
T37555	Cardanol triene
	Cardanol triene is a phenol found in cashew nut shell liquid that reversibly inhibits tyrosinase with an IC50 value of 40.5 μM in vitro. A mixture of cardanol mono-, di-, and triene is used to synthesize cardanol-metal complexes that inhibit uropathogenic E. coli biofilm formation.
T69771	MS-177
	MS177 is an effective and fast-acting EZH2 degrader. MS177 is a PROTAC that consists of a CRBN ligand, linker, and a potent enzymatic EZH2 inhibitor C24 (C24 IC50): 12 nM). MS177 effectively depletes both canonical EZH2–PRC2 and noncanonical EZH2–cMyc complexes. MS177 induces leukaemia cell growth inhibition, apoptosis and cell cycle progression arrest.
T77168	Sevirumab
	Sevirumab (MSL-109) 是一种人抗巨细胞病毒 (CMV)IgG1中和单克隆抗体。Sevirumab 识别CMVgH 复合物，抑制CMV 复制，EC50为 0.3 μg/mL。
T82574	DFAME
	DFAME为一种帶有红色荧光的基团（Ex=508 nm，Em=641 nm）。它能与二聚体荧光RNA适体Beetroot及Corn结合，分别形成Beetroot-DFAME复合体（Kd=460 nM）和Corn-DFAME复合体（Kd=3600 nM）。这两种复合体可应用于细胞内RNA组装体的形成，利用RNA结构的自组装特性研究RNA纳米结构。
T79680	PSEN1-IN-2
	PSEN1-IN-2（Compound 13K）为一种针对PSEN1的抑制剂，对PSEN1-APH1A与PSEN1-APH1B复合体展现出高效抑制活性，其IC50值分别为6.9 nM及2.4 nM。本化合物适用于阿尔茨海默病的科学研究领域。
T79196	4-Thiouridine 5′-triphosphate tetralithium 4-Thio-UTP tetralithium	P2Y Receptor	GPCR/G Protein; Neuroscience
	4-Thiouridine 5’-triphosphate (4-Thio-UTP) tetralithium 作为P2Y2和P2Y4受体的高效激动剂，其对hP2Y2的EC50为35 nM，对hP2Y4的EC50为350 nM。该化合物广泛应用于交联实验以及转录复合物标记研究。
T79679	PSEN1-IN-1
	PSEN1-IN-1（化合物(+)‑13b）为选择性PSEN1抑制剂，针对PSEN1-APH1A及PSEN1-APH1B复合物显示出高效抑制活性，IC50 值分别达到19 nM与5.5 nM。该化合物适用于阿尔茨海默病的研究领域。
T34807	Terephthalamidine terephthalimidamide
	Terephthalamidine is a derivative of the phthalanilide compounds. Terephthalamidine belongs to a family of compounds which appear to reversibly bind to the minor groove of the DNA double helix but not intercalate DNA. This agent also has been suggested to
T70956	JNJ-pan-AR
	JNJ-pan-AR, a meylated analogue of JNJ-63576253, is a novel pan-AR antagonist with potent activity against wild-type and clinically relevant AR mutations including F877L. JNJ63576253, also known as TRC253, is a potent and orally active androgen receptor antagonist. TRC253 specifically binds to both wild-type and certain mutant forms of AR, thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot translocate to the nucleus.
T63126	Cas9-IN-2
	Cas9-IN-2 是一种 Cas9 的有效抑制剂，其 IC50 值为 246 μM。Cas9-IN-2 能够结合 apo-Cas9，进而防止 Cas9:gRNA 复合物的形成。Cas9-IN-2 能够用于调节和控制 Cas9 的活性。
T29033	U-7524 2-Aminooxyacetic acid,U 7524,Aminooxyacetic acid,U7524,AOAA
	U-7524, also known as AOAA and Aminooxyacetic acid, is an inhibitor of 4-aminobutyrate aminotransferase (GABA-T). AOAA is also a general inhibitor of pyridoxal phosphate (PLP)-dependent enzymes (this includes GABA-T). It functions as an inhibitor by attac
T70296	JJO-1
	JJO-1 is a bi-quinoline that allosterically activates all AMPK αβγ isoforms in vitro except complexes containing the γ3 subunit. JJO-1 does not directly activate the autoinhibited α subunit kinase domain and differs among other known direct activators of AMPK in that allosteric activation occurs only at low ATP concentrations, and is not influenced by either mutation of the γ subunit adenylate-nucleotide binding sites or deletion of the β subunit carbohydrate-binding module.

化合物

Cat.No: T19235

Target: Others

Diisopropyl xanthogen disulfide

Cat.No: T31479

Synonym: NSC1339,NSC 1339,Isopropylxanthic disulfide,二硫化二异丙基黄原酸酯,NSC-1339

Target: Others

Cat.No: T36411

Target: Others

Potassium thioacetate

Cat.No: T22402

Target: Others

Tris(benzyltriazolylmethyl)amine

Cat.No: T7086

Synonym: 三[(1-苄基-1H-1,2,3-三唑-4-基)甲基]胺,TBTA

Target: Others

Salicylaldoxime

Cat.No: T20346

Target: Others

Nicotinic acid hydrazide

Cat.No: T0664

Target: Others

Cat.No: T16348

Synonym: NS-5806

Target: Potassium Channel

Cat.No: T3317

Target: Apoptosis, Others, E1/E2/E3 Enzyme

Lenalidomide hemihydrate

Cat.No: T22922

Target: TNF, Ligand for E3 Ligase, Molecular Glues

Cat.No: T14778

Target: IL Receptor, CDK, Interleukin

Cat.No: T3940

Synonym: BCL6 inhibitor

Target: Apoptosis, BCL

N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)pyrazine-2-carboxamide

Cat.No: T9679

Target: Antibacterial

Cat.No: T2410

Synonym: 奈达铂,NSC 375101D

Target: DNA/RNA Synthesis

Cat.No: T61111

Target: TNF

Cat.No: T8796

Target: CDK

Lauryl maltose neopentyl glycol

Cat.No: T38651

Synonym: LMNG

Cat.No: T68002

Target: Thrombin

Cat.No: T24654

Cat.No: T31035

Synonym: CP-85339,CP85339,CP-85,339

Manganese carbonyl

Cat.No: T21070

Synonym: Dimanganese decacarbonyl,Decacarbonyldimanganese

Cat.No: T30763

Synonym: CB3731,CB-3731

Cat.No: T10605

Target: Others

AMPK Activator SC4

Cat.No: T70862

Pyrithione sodium

Cat.No: T26004

Synonym: SQ-3277,SQ3277,SQ 3277

Cat.No: T39366

Netropsin dihydrochloride

Cat.No: T12209

Target: Others

Cat.No: T34053

Cat.No: T23874

Melagatran monohydrate

Cat.No: T69456

Bis-PEG1-C-PEG1-CH2COOH

Cat.No: T18619

Synonym: PROTAC Linker 26

Target: Others

EGFRvIII peptide (PEPvIII)

Cat.No: TP1589

Synonym: EGFRvIII peptide PEPvIII

Bis-propargyl-PEG3

Cat.No: T14656

Target: Others

Cat.No: T71813

Cat.No: T74246

Cat.No: T71385

Cat.No: T36700

Cat.No: T27687

Synonym: JNJ 525,JNJ-525

Cardanol triene

Cat.No: T37555

Cat.No: T69771

Cat.No: T77168

Cat.No: T82574

Cat.No: T79680

4-Thiouridine 5′-triphosphate tetralithium

Cat.No: T79196

Synonym: 4-Thio-UTP tetralithium

Target: P2Y Receptor

Cat.No: T79679

Terephthalamidine

Cat.No: T34807

Synonym: terephthalimidamide

Cat.No: T70956

Cat.No: T63126

Cat.No: T29033

Synonym: 2-Aminooxyacetic acid,U 7524,Aminooxyacetic acid,U7524,AOAA

Cat.No: T70296

Cat. No.	Product Name	Target	Signaling Pathways
TN1243	3-Aminocoumarin 3-Amino-2-benzopyrone,3-aminochromen-2-one,Coumarin amine	Others	Others
	3-Aminocoumarin (3-aminochromen-2-one) 是金属配合物的关键中间体。
TN1081	Hirsuteine	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Hirsuteine 是提取自钩藤属植物中的吲哚生物碱。它可阻断离子渗透通过烟碱受体通道复合物，非竞争性地拮抗烟碱介导的多巴胺释放。
T7929	L-Aspartic Acid 4-Benzyl Ester	Others	Others
	L-Aspartic Acid 4-Benzyl Ester 是一种螯合剂，与金属离子形成稳定的络合物，已用于研究金属离子对酶活性的影响，以及研究金属离子在基因表达调控中的作用等。
T2930	α-Lipoic Acid Lipoic acid,Alphalipoic acid,硫辛酸	NF-κB; HIV Protease; Mitochondrial Metabolism; Endogenous Metabolite	Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
	α-Lipoic Acid (Alphalipoic acid) 抑制 NF-κB 依赖性 HIV-1 LTR 活化。 α-硫辛酸诱导内质网 (ER) 应激介导的肝癌细胞凋亡。α-硫辛酸是一种抗氧化剂，是线粒体酶复合物的重要辅助因子。
T7998	1,7-Diaminoheptane	Others	Others
	1,7-Diaminoheptane 是一种脂族胺家族的化合物。它可用于合成肽、拟肽和其他化合物，也被用作酶反应中的底物，金属配合物中的配体，以及有机合成中的试剂。
T16223	N-Dodecyl-β-D-maltoside 十二烷基-β-D-麦芽糖苷,Lauryl Maltoside	Others	Others
	N-Dodecyl-β-D-maltoside (Lauryl Maltoside) 是一种芘 (Py) 的衍生物。它可用作烷基吡喃麦芽糖苷清洁剂，尤其是在转运蛋白和呼吸复合物中。它已用于诸如 RNA 聚合酶的纯化和稳定化，以及蛋白质-脂质相互作用的检测的应用中。
TN4883	Quinine sulfate dihydrate 奎宁树	Others	Others
	Quinine sulfate dihydrate 在钾通道阻滞剂中起主要作用。它也被用作抗疟疾、抗胆碱能、抗高血压和降糖药。它抑制线粒体atp 调节的钾通道。它也被用来研究生物结晶血红素，血红素，在疟疾寄生虫的代谢和研究血红素(FP)复合物的毒性。
T7963	2,4-Dihydroxypyridine	Others	Others
	2,4-Dihydroxypyridine 是一种吡啶衍生物，作为螯合剂与金属离子结合并形成络合物。它被用作测定各种离子浓度的试剂，如钙、镁和磷酸盐；也用于测量酶催化反应的速率；还用于蛋白质、碳水化合物和其他生物分子的检测和定量。
T1331	Riboflavin phosphate sodium Riboflavin 5'-phosphate sodium,核黄素磷酸钠(维生素B2),Vitamin B2 Phosphate Sodium Salt,Flavin mononucleotide,FMN,核黄素磷酸钠,FMN-Na,riboflavin-5'-phosphate	Endogenous Metabolite	Metabolism
	Riboflavin phosphate sodium (FMN) 是 riboflavin 的磷酸钠盐形式，riboflavin 是一种水溶性和必需的微量营养素，是自然产生的维生素B复合物的主要生长促进因子。Riboflavin phosphate sodium 转化为2种辅酶，黄素单核苷酸(FMN)和黄素腺嘌呤二核苷酸(FAD)，这两种辅酶通过帮助脂肪、碳水化合物和蛋白质的代谢来产生能量，并且是红细胞形成和呼吸、抗体产生以及调节人体生长和繁殖所必需的。
T68731	Myxothiazol
	Myxothiazol is an inhibitor of mitochondrial respiratory chain complexes III. Myxothiazol induces transcription of the p53-responsive SESN2 gene that plays an important role in stress response and homeostatic regulation.
T72429	α-Lipoic Acid sodium Thioctic acid sodium,DL-α-Lipoic acid sodium,Thioctic acid sodium ; (±)-α-Lipoic acid sodium ; DL-α-Lipoic acid sodium,(±)-α-Lipoic acid sodium
	α-Lipoic Acid (Thioctic acid) sodium 是一种抗氧化剂，是线粒体酶复合物的重要辅助因子。α-Lipoic Acid sodium 可抑制NF-κB 依赖性的HIV-1LTR 活化。α-Lipoic Acid sodium 诱导内质网应激 (ERS) 介导的肝癌细胞凋亡 (apoptosis)。α-Lipoic Acid sodium 可与CPUL1 合成自组装的纳米聚合体 CPUL1-LA NA，其抗肿瘤效果优于 CPUL1。
TN2775	2-Methoxystypandrone	MMP; BCL; IκB/IKK; GSK-3; TNF; NOS; NF-κB; Wnt/beta-catenin; COX; JAK; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
	2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-ÎºB signaling to limit the inflammation and oxidative stress for preservation of BBB integrity. 2-Methoxystypandrone concomitant
T35667	Napyradiomycin A1 Napyradiomycin A1
	Napyradiomycin A1is a fungal metabolite originally isolated fromC. rubraand has diverse biological activities.1,2It is active againstS. aureus,M. luteus,B. anthracis,C. bovis, andM. smegmatis(MICs = 1.56-12.5 μg/ml).1Napyradiomycin A1is an estrogen receptor antagonist (IC50= 4.2 μM in rat uterine homogenates).2It also inhibits mitochondrial NADH:ubiquinone oxidoreductase (complex I) and succinate:ubiquinone oxidoreductase (complex II) activities in bovine heart homogenates (IC50s = 20 and 9.7 μM...

天然产物

3-Aminocoumarin

Cat.No: TN1243

Synonym: 3-Amino-2-benzopyrone,3-aminochromen-2-one,Coumarin amine

Target: Others

Cat.No: TN1081

Target: Dopamine Receptor

L-Aspartic Acid 4-Benzyl Ester

Cat.No: T7929

Target: Others

Cat.No: T2930

Synonym: Lipoic acid,Alphalipoic acid,硫辛酸

Target: NF-κB, HIV Protease, Mitochondrial Metabolism, Endogenous Metabolite

1,7-Diaminoheptane

Cat.No: T7998

Target: Others

N-Dodecyl-β-D-maltoside

Cat.No: T16223

Synonym: 十二烷基-β-D-麦芽糖苷,Lauryl Maltoside

Target: Others

Quinine sulfate dihydrate

Cat.No: TN4883

Synonym: 奎宁树

Target: Others

2,4-Dihydroxypyridine

Cat.No: T7963

Target: Others

Riboflavin phosphate sodium

Cat.No: T1331

Synonym: Riboflavin 5'-phosphate sodium,核黄素磷酸钠(维生素B2),Vitamin B2 Phosphate Sodium Salt,Flavin mononucleotide,FMN,核黄素磷酸钠,FMN-Na,riboflavin-5'-phosphate

Target: Endogenous Metabolite

Cat.No: T68731

α-Lipoic Acid sodium

Cat.No: T72429

Synonym: Thioctic acid sodium,DL-α-Lipoic acid sodium,Thioctic acid sodium ; (±)-α-Lipoic acid sodium ; DL-α-Lipoic acid sodium,(±)-α-Lipoic acid sodium

2-Methoxystypandrone

Cat.No: TN2775

Target: MMP, BCL, IκB/IKK, GSK-3, TNF, NOS, NF-κB, Wnt/beta-catenin, COX, JAK, STAT

Napyradiomycin A1

Cat.No: T35667

Synonym: Napyradiomycin A1

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