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107

抑制剂 & 化合物

21

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T6793	BRD7552	Others	Others
	BRD7552 是PDX1转录因子诱导剂，它能够上调人类原代胰岛和导管细胞中 PDX1 的表达，诱导 PDX1 启动子的表观遗传变化与转录激活一致，提高胰岛素表达。其中 PDX1 是参与胰腺发育和β细胞功能的关键转录因子。
T19853	Dimethoxycurcumin Veratrylcurcuminoid,二甲氧基姜黄素	Others	Others
	Dimethoxycurcumin (Veratrylcurcuminoid) 是 curcumin 衍生物，拥有抗氧化及抗炎作用。
T14994	Coelenterazine h 腔肠素-H,2-Deoxycoelenterazine,CLZN-h	Others	Others
	Coelenterazine h (CLZN-h) 是一种 Coelenterazine 的衍生物。它对 Ca2+比它的天然复合物更敏感，是一种能够测量 Ca2+浓度的微小变化的有效工具。
T14057	6-CFDA 6-羧基荧光素二醋酸,6-Carboxyfluorescein diacetate	Others	Others
	6-CFDA (6-Carboxyfluorescein diacetate) 是可用于流式细胞术和荧光显微镜的荧光探针，也可以用于活体多光子显微镜研究动物肝胆代谢。
T68165	Trapencaine
	Trapencaine 是一种新合成的氨基甲酸型局部麻醉剂，诱导的肥大细胞膜上钠通道的构象变化。
T9325	2-(2-Aminothiazole-4-yl)-2-methoxyiminoa	Others	Others
	2-(2-Aminothiazole-4-yl)-2-methoxyiminoa 是一种蛋白质酪氨酸磷酸酶的抑制剂，蛋白质酪氨酸磷酸酶可以导致细胞信号通路的变化，从而影响细胞的行为。
T2011	RKI1313 RKI 1313,RKI-1313	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	RKI1313 (RKI-1313) 是一种选择性抑制剂，可抑制 ROCK 依赖性信号传导、细胞骨架变化、不依赖锚定的集落形成、迁移和侵袭。
T77556	2-(4-Hydroxyphenylazo)benzoicacid
	2-(4-Hydroxyphenylazo)benzoicacid 是一种分光光度法探针，可显示与蛋白质结合时的吸收光谱变化，可与牛血清蛋白结合。
T4683	Alovudine 3'-Deoxy-3'-fluorothymidine,3'-脱氧-3-氟胸苷	Antiviral	Immunology/Inflammation
	Alovudine (3'-Deoxy-3'-fluorothymidine) 是一种 DNA 合成的标志物。与18F-Fluorodeoxyglucose (FDG) 相比，它不易受炎症变化的影响，在胰腺癌中，它是更好的生物标志物。
T5104	BTSA1	Apoptosis; BCL	Apoptosis
	BTSA1 是一种有口服活性的 BAX 激活剂，IC50为 250 nM，EC50为 144 nM。它以高亲和力和特异性与 N 末端激活位点结合，并诱导 BAX 发生构象变化，从而导致BAX 介导的细胞凋亡。
T22229	Acid Yellow 36 Metanil Yellow,酸性黄36	Others	Others
	Acid Yellow 36 (Metanil Yellow) 是一种偶氮染料和 pH 指示剂，当 pH 值从 1.2 到 2.3 时，发生由红色到黄色的颜色转变。它是 P-450 特异性同工酶和胞浆酶的双功能诱导剂，可用于皮革、造纸和纺织工业。
T6760	APS-2-79 hydrochloride APS-2-79 HCl,APS-2-79	MEK; MAPK	MAPK
	APS-2-79 hydrochloride (APS-2-79 HCl) 是一种 KSR 依赖性的MEK 拮抗剂，可与 ATPbiotin 竞争性地结合到 KSR2-MEK1 复合物内的KSR2。它与 KSR 结合可将 KSR 处于非活性状态，使其无法再结合 RAF 和激活 MEK，从而阻断 Ras-MAPK 信号通路。
T24076	FzM1 FzM 1,FzM-1	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	FzM1 是卷曲蛋白受体 FZD4 的负变构调节剂 (NAM)。 FzM1减少 WNT5A 依赖的 WNT 反应元件 (WRE) 活性 (log EC50inh=-6.2)。 FzM1 与位于 FZD4 细胞内环 3 (ICL3) 的变构结合位点结合并改变受体的构象，从而抑制 WNT/β-连环蛋白级联反应。
T33613	NCGC00135472 NCGC 00135472,DRV1 (GPR32) agonist C2A,C2A,NCGC-00135472	Others	Others
	NCGC00135472 (DRV1 (GPR32) agonist C2A)是具有促分解功能的人Resolvin D1受体激动剂,可在β阻滞素和 cAMP 测定中激活人溶解蛋白 D1 受体 DRV1/GPR32 受体，EC50 分别为 0.37 uM 和 0.05 uM。NCGC00135472在过表达重组DRV1的细胞中引起快速阻抗变化，刺激血清处理的酶聚糖的吞噬作用。
T63971	Canocapavir ZM-H1505R	HBV	Microbiology/Virology
	Canocapavir (ZM-H1505R)是一种新型可口服的 HBV 衣壳蛋白调节剂，具有抗病毒活性，可诱导 HBV 核心蛋白连接子区域的构象变化，可用于治疗乙型肝炎病毒。
T22694	CRANAD 2	Others	Others
	CRANAD 2 是一种特异性近红外 (NIR) 荧光探针，可用于检测 Aβ 斑块。它可透过血脑屏障，且对 Aβ 聚集体有高亲和性，其 Kd=38 nM。
T3126	Bethanechol chloride (±)-Bethanechol,Urecholine,Myocholine,氯贝胆碱,Carbamyl-β-methylcholine chloride	AChR	Neuroscience
	Bethanechol chloride (Carbamyl-β-methylcholine chloride) 是一种拟副交感神经剂，是毒蕈碱型受体 (mAChR) 激动剂，通过直接刺激副交感神经系统的 mAChR 发挥作用。
T4364	Aftin-4 Aftin 4,Aftin4	Beta Amyloid; Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	Aftin-4 是一种 β-淀粉样蛋白42(Aβ42) 的诱导剂。
T36008	Nebentan potassium
	Nebentan potassium (YM598) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist through the modification of Bosentan . Nebentan potassium inhibits [125I] endothelin-1 binding to cloned human endothelin ETA and ETB receptor, with Ki of 0.697 nM and 569 nM, respectively[1]. YM598 can ameliorate the progression of cor pulmonale and myocardial infarction in vivo[2]. Nebentan potassium inhibits the specific binding of [125I] endothelin-1 to endothelin ETA and ETB re...
T32681	Leukotriene F-4 sulfone Ltf4 sulfone
	Leukotriene F-4 sulfone induces vascular permeability changes.
T19476	NHC-triphosphate	Others	Others
	NHC-triphosphate is a weak alternative substrate for the viral polymerase and changes the mobility of the product in polyacrylamide electrophoresis gels.
T68327	Dexnafenodone Free Base
	Dexnafenodone Free Base is a potent inhibitor of noradrenaline, and to a lesser degree of serotonin reuptake, induced changes in the pattern of sleep which are comparable to those of non‐sedating tricyclic antidepressants.
T26395	6-Benzylthioinosine 6-BT,6Benzylthioinosine,6-Bn-thioinosine
	6-Benzylthioinosine, a broad-spectrum metabolic inhibitor, inhibits glucose uptake, decreases glycolysis and ATP concentration with minimal changes in ROS and mitochondrial respiration.
T23697	AL-8417 J1.090.276B,AL8417,(2R)-AL-5898
	AL-8417 is an enzyme inhibitor. It acting as an antioxidant, anti-inflammatory, and cytostatic agent. It also has the ability to suppress vitrectomy-induced posterior lens fiber changes.
T18973	Di-8-ANEPPS	Others	Others
	Di-8-ANEPPS, a voltage-sensitive dye, demonstrates shifts in both its fluorescence excitation and emission spectra in response to changes in membrane potential (Vm).
T69017	Ibotenic acid hydrate
	Ibotenic acid hydrate is a neurotoxic isoxazole (similar to Kainic acid and Muscimol) found in Amanita mushrooms. It causes motor depression, ataxia, and changes in mood, perceptions and feelings, and is a potent excitatory amino acid agonist.
T33417	MK 410 MK-410,MK410
	MK 410 is an indomethacin analogue and anti-inflammatory agent that induces changes in the immune system by inhibiting plasma neutral protease activity.
T12934	SMAP-2 DT-1154	Phosphatase	Metabolism
	SMAP-2 is an orally bioavailable activator of phosphatase 2A (PP2A) which binds to the PP2A Aα scaffold subunit to drive conformational changes in PP2A. It inhibits the growth of KRAS-mutant lung cancers .
T31088	CPX-351 Cytarabine/daunonubicin,Vyxeos,CPX 351,Daunonubicin/cytarabine
	CPX-351 is a Liposomal-encapsulated combination of daunorubicin and cytarabine for the treatment of newly diagnosed tAML or AML with myelodysplasia-related changes (AML-MRCs).
T18884	3,3'-Dihexyloxacarbocyanine iodide DiOC6(3) iodide	Others	Others
	3,3'-Dihexyloxacarbocyanine iodide is a carbocyanine dye. It is used to monitor changes in mitochondrial membrane potential.
TP1311	RGD peptide (GRGDNP) (TFA) (114681-65-1 free base) RGD peptide (GRGDNP) (TFA)
	RGD peptide (GRGDNP) (TFA) promote apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing.
T13746	KMG-301AM	Others	Others
	KMG-301AM, the acetoxy methyl esterified form of KMG-301, facilitates the acquisition of time-course and pseudo-colored images depicting the changes in mitochondrial fluorescence when stained with KMG-301.
T68898	Dequalinium Bromide
	Dequalinium Bromide is a HIV-1 fusion inhibitor, targeting the membrane-proximal external region of Env spikes, specifically inhibiting the HIV-1 envelope-mediated membrane fusion by blocking CD4-induced conformational changes.
TP1105	α-Factor Mating Pheromone, yeast (TFA) α-Factor Mating Pheromone, yeast (TFA)(59401-28-4,FREE),Mating Factor α (TFA)
	The alpha factor pheromone arrests yeast in the G1 phase of their cell cycle. Alpha Factor Mating Pheromone induces the expression of mating genes, changes in nuclear architecture, and polarzes growth toward the mating partner.
T68600	Enoximone sulfoxide
	Enoximone sulfoxide is a selective phosphodiesterase III (PDE3) inhibitor with vasodilating and positive inotropic activity that does not cause changes in myocardial oxygen consumption. Enoximone prevents the degradation of cAMP by PDE, which prolongs signal transduction and its subsequent effects. It is used in patients with congestive heart failure.
T36081	Trehalose 6-phosphate (potassium salt hydrate)
	Trehalose is a natural non-reducing disaccharide found in plants, invertebrates, fungi, and bacteria.1,2In addition to roles as an energy source and stress protectant, trehalose can function as a signaling molecule.3,4Trehalose 6-phosphate is an intermediate in the biosynthesis of trehalose. It is generated from UDP-glucose and glucose 6-phosphate by trehalose 6-phosphate synthase (TPS or otsA).5In plants, changes in trehalose 6-phosphate levels positively correlate with diurnal changes in sucro...
T29453	5-Formylcytosine
	5-formylcytosine (5FC) is a rare base found in mammalian DNA. It participates in active DNA demethylation, changes DNA double helix structure, and reduces the transcription rate and substrate specificity of RNA polymerase II.
T80322	Mastoparan B
	Mastoparan B，源自黄蜂Vespa的抗菌肽，可引起红细胞形态由常规盘形转变为锯齿状。
T69769	BDP8900
	BDP8900 is a potent and selective MRCK inhibitor, reducing substrate phosphorylation. BDP8900 leads to morphological changes in cancer cells along with inhibition of their motility and invasive character.
T26821	BIPM
	BIPM is a potent inhibitor of Rho-associated protein kinase 2 (ROCK2). Exposure of SH-SY5Y cells to BIPM led to significant changes in cell migration, actin stress fibers and neurite length. BIPM significantly inhibits phosphorylation of cofilin, a regula
T20256	Sorbitol, L- L-Glucitol
	Sorbitol, L- is a sugar alcohol. It can be obtained by the reduction of glucose, which changes the aldehyde group to a hydroxyl group. It is converted to fructose by sorbitol-6-phosphate 2-dehydrogenase. Sorbitol is an isomer of mannitol, another sugar al
T35820	CAY10685
	CAY10685 is a cell-active analog of the lysine acetyltransferase inhibitor CPTH2 that contains an alkyne moiety for use in click chemistry reactions. Its ability to inhibit N-acetyltransferase 10 activity has been used to modulate chromatin organization in order to study changes in nuclear architecture associated with cancer and certain laminopathies.
T15180	Duocarmycin A	Caspase	Apoptosis; Proteases/Proteasome
	Duocarmycin A, an antitumor antibiotic, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results in HLC-2 cells typically apoptotic changes.
T61702	SRI-37240
	SRI-37240 is a powerful inhibitor of premature termination codons (PTCs). It effectively suppresses CFTR nonsense mutations and induces changes in cellular translation termination at PTCs in HEK293T cells. Additionally, when combined with G418, SRI-37240 restores CFTR function in primary bronchial epithelial cells [1].
T81337	Pyrromethene 650 PM650
	Pyrromethene 650 (PM650)为一种绿色荧光偏振示踪染料，常用于膜融合、裂解及隙缝结通讯的研究，并可检测细胞或脂质体的体积变化。
TD0052	Fluo-3, pentasodium salt
	Calcium measurement is critical for numerous biological investigations. Fluorescent probes that show spectral responses upon binding calcium have enabled researchers to investigate changes in intracellular free calcium concentrations by using fluorescence microscopy, flow cytometry, fluorescence spectroscopy and fluorescence microplate readers. Fluo-3, pentasodium salt is most commonly used among the visible light-excitable calcium indicators.
TD0054	Fluo-3, pentaammonium salt
	Calcium measurement is critical for numerous biological investigations. Fluorescent probes that show spectral responses upon binding calcium have enabled researchers to investigate changes in intracellular free calcium concentrations by using fluorescence microscopy, flow cytometry, fluorescence spectroscopy and fluorescence microplate readers. Fluo-3, pentaammonium salt is most commonly used among the visible light-excitable calcium indicators.
TD0053	Fluo-3, pentapotassium salt
	Calcium measurement is critical for numerous biological investigations. Fluorescent probes that show spectral responses upon binding calcium have enabled researchers to investigate changes in intracellular free calcium concentrations by using fluorescence microscopy, flow cytometry, fluorescence spectroscopy and fluorescence microplate readers. Fluo-3, pentapotassium salt is most commonly used among the visible light-excitable calcium indicators.
T11042	Dihydrocytochalasin B	Others	Others
	Dihydrocytochalasin B (H2CB) is a cell division inhibitor that changes the morphology of cells, similar to cytochalasin B. Does not inhibit glucose transport. Dihydrocytochalasin B (H2CB) disrupts the structure of actin and inhibits the ability of growth
T30242	AY 31906 AY-31,906
	AY 31906 is a high ceiling diuretic with a relative potassium-sparing effect. AY 31906 has been shown to produce significant increases in the fractional excretion of sodium and chloride in dogs at a dose that produces no statistically significant changes

化合物

Cat.No: T6793

Target: Others

Dimethoxycurcumin

Cat.No: T19853

Synonym: Veratrylcurcuminoid,二甲氧基姜黄素

Target: Others

Coelenterazine h

Cat.No: T14994

Synonym: 腔肠素-H,2-Deoxycoelenterazine,CLZN-h

Target: Others

Cat.No: T14057

Synonym: 6-羧基荧光素二醋酸,6-Carboxyfluorescein diacetate

Target: Others

Cat.No: T68165

2-(2-Aminothiazole-4-yl)-2-methoxyiminoa

Cat.No: T9325

Target: Others

Cat.No: T2011

Synonym: RKI 1313,RKI-1313

Target: ROCK

2-(4-Hydroxyphenylazo)benzoicacid

Cat.No: T77556

Cat.No: T4683

Synonym: 3'-Deoxy-3'-fluorothymidine,3'-脱氧-3-氟胸苷

Target: Antiviral

Cat.No: T5104

Target: Apoptosis, BCL

Cat.No: T22229

Synonym: Metanil Yellow,酸性黄36

Target: Others

APS-2-79 hydrochloride

Cat.No: T6760

Synonym: APS-2-79 HCl,APS-2-79

Target: MEK, MAPK

Cat.No: T24076

Synonym: FzM 1,FzM-1

Target: Wnt/beta-catenin

Cat.No: T33613

Synonym: NCGC 00135472,DRV1 (GPR32) agonist C2A,C2A,NCGC-00135472

Target: Others

Cat.No: T63971

Synonym: ZM-H1505R

Target: HBV

Cat.No: T22694

Target: Others

Bethanechol chloride

Cat.No: T3126

Synonym: (±)-Bethanechol,Urecholine,Myocholine,氯贝胆碱,Carbamyl-β-methylcholine chloride

Target: AChR

Cat.No: T4364

Synonym: Aftin 4,Aftin4

Target: Beta Amyloid, Gamma-secretase

Nebentan potassium

Cat.No: T36008

Leukotriene F-4 sulfone

Cat.No: T32681

Synonym: Ltf4 sulfone

NHC-triphosphate

Cat.No: T19476

Target: Others

Dexnafenodone Free Base

Cat.No: T68327

6-Benzylthioinosine

Cat.No: T26395

Synonym: 6-BT,6Benzylthioinosine,6-Bn-thioinosine

Cat.No: T23697

Synonym: J1.090.276B,AL8417,(2R)-AL-5898

Cat.No: T18973

Target: Others

Ibotenic acid hydrate

Cat.No: T69017

Cat.No: T33417

Synonym: MK-410,MK410

Cat.No: T12934

Synonym: DT-1154

Target: Phosphatase

Cat.No: T31088

Synonym: Cytarabine/daunonubicin,Vyxeos,CPX 351,Daunonubicin/cytarabine

3,3'-Dihexyloxacarbocyanine iodide

Cat.No: T18884

Synonym: DiOC6(3) iodide

Target: Others

RGD peptide (GRGDNP) (TFA) (114681-65-1 free base)

Cat.No: TP1311

Synonym: RGD peptide (GRGDNP) (TFA)

Cat.No: T13746

Target: Others

Dequalinium Bromide

Cat.No: T68898

α-Factor Mating Pheromone, yeast (TFA)

Cat.No: TP1105

Synonym: α-Factor Mating Pheromone, yeast (TFA)(59401-28-4,FREE),Mating Factor α (TFA)

Enoximone sulfoxide

Cat.No: T68600

Trehalose 6-phosphate (potassium salt hydrate)

Cat.No: T36081

5-Formylcytosine

Cat.No: T29453

Cat.No: T80322

Cat.No: T69769

Cat.No: T26821

Cat.No: T20256

Synonym: L-Glucitol

Cat.No: T35820

Cat.No: T15180

Target: Caspase

Cat.No: T61702

Pyrromethene 650

Cat.No: T81337

Synonym: PM650

Fluo-3, pentasodium salt

Cat.No: TD0052

Fluo-3, pentaammonium salt

Cat.No: TD0054

Fluo-3, pentapotassium salt

Cat.No: TD0053

Dihydrocytochalasin B

Cat.No: T11042

Target: Others

Cat.No: T30242

Synonym: AY-31,906

Cat. No.	Product Name	Target	Signaling Pathways
T2803	Monocrotaline 野百合碱,Crotaline	TGF-beta/Smad	Stem Cells
	Monocrotaline (Crotaline) 是一种吡咯里西啶生物碱，从猪屎豆植物的种子中提取得到，可诱导啮齿动物产生肺动脉高血压。
TF0083	POPE
	POPE 是从大肠杆菌中发现的化合物，是细胞膜的一部分，可用来研究改变细胞膜通透性。
TN6779	Clausine E	Others	Others
	Clausine E 是脂肪量和肥胖相关蛋白 (FTO) 脱甲基酶活性的抑制剂。 Clausine E 与 FTO 的结合是由正熵和负焓变化驱动的。
T4732	L-Carnosine Karnozin,L-肌肽,beta-Alanyl-L-histidine	Antioxidant; Endogenous Metabolite	Metabolism; oxidation-reduction
	L-Carnosine (Karnozin) 是由beta-丙氨酸和组氨酸组成的二肽，具有抑制衰老的作用。
T10023	1-Naphthol NSC 9586,Nako TRB,1-萘酚,Furro ER	Endogenous Metabolite	Metabolism
	1-Naphthol (Furro ER) 是激发态质子转移荧光分子探针。
TN1248	3-Epioleanolic acid	AChR	Neuroscience
	3-Epioleanolic acid 是一种分离自马鞭草的有效成分，具有抗炎作用。
TN7117	regaloside I	Others	Others
	Regaloside I 是百合中的单体成分,可能是保护人类皮肤成纤维细胞免受 UVA 诱导的形态变化的主要成分。
T5968	DL-Homocysteine thiolactone hydrochloride DL-Homocysteinethiolactone hydrochloride,DL-高半胱氨酸硫内酯盐酸盐	Endogenous Metabolite	Metabolism
	DL-Homocysteine thiolactone hydrochloride (DL-Homocysteinethiolactone hydrochloride) 是具有根生长抑制特性的环状氨基酸衍生物。
T4939	Indole-3-pyruvic acid 3-(3-吲哚基)-2-氧代丙酸,3-(3-Indolyl)-2-oxopropanoic acid	Others	Others
	Indole-3-pyruvic acid (3-(3-Indolyl)-2-oxopropanoic acid) 是一种参与Indole-3-acetic acid 生物合成的化合物，Indole-3-acetic acid 是一种植物激素，在调节生长和对环境变化的反应中起重要作用。
T5061	Lumichrome 7,8-Dimethylalloxazine,光色素	Others	Others
	Lumichrome (7,8-Dimethylalloxazine) 是人类体内的内源性化合物，由核黄素光降解产生。它利用 p53 依赖机制抑制人肺癌细胞生长并诱导凋亡。
T35455	N-Nitrosodiethylamine Diethylnitrosamine,NDEA	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	N-Nitrosodiethylamine (NDEA) 是致癌物质二烷基硝胺。它主要存在于水、烟草烟雾、腌制食品、油炸食品以及许多酒精饮料中。它与 DNA 修复/复制相关的核酶的变化相关。
T2S2173	(E)-Naringenin chalcone Isosalipurpol,柚皮苷查尔酮,Chalconaringenin,trans-2'4'6'4-tetrahydroxychalcone,柚皮素查耳酮	Others	Others
	Naringenin chalcone (Isosalipurpol) 是一种黄酮醇生物合成的中间体，在查耳酮异构酶的作用下，自发代谢成柚皮素。它具有抗炎和抗过敏活性。
T1311	4-aminobenzoic acid PABA,Vitamin H1,Vitamin Bx,para-Aminobenzoic acid,对氨基苯甲酸	Endogenous Metabolite	Metabolism
	4-aminobenzoic acid (para-Aminobenzoic acid) 是一种具有紫外线吸收和抗纤维化特性的有机酸。当暴露在光线下时，4-aminobenzoic acid 吸收紫外线并通过光化学反应释放多余的能量，这可能会对DNA造成损害。4-aminobenzoic acid 还可以增加组织水平的摄氧量，并可能增强单胺氧化酶(MAO)活性以促进血清素的降解，过量可能导致纤维化变化。
T4719	1,4-D-Gulonolactone D-Gulonic acid γ-lactone,D-(-)-古洛糖酸-1,4-内酯	Others; Endogenous Metabolite	Metabolism; Others
	1,4-D-Gulonolactone (D-Gulonic acid γ-lactone) (也称为还原性抗坏血酸，RAA) 是 L-gulono-1,4-lactone oxidoreductase (EC 1.1.3.8)的底物，催化植物和动物中l -抗坏血酸(维生素C)生物合成的最后一步。enzyme L-Gulono-1,4-lactone oxidase 在容易患坏血病、缺乏维生素c的动物(如人类)中缺失。1,4-D-Gulonolactone 存在于人体血液中，并被用作比较运动引起的氧化应激变化的标志物之一。
T8098	γ-Hexalactone γ-caprolactone,gamma-己内酯,γ-己内酯	Others	Others
	γ-Hexalactone (γ-caprolactone) 是一种存在成熟水果中的 gamma 内酯。它会导致 DNA 损伤，可用作对氧磷酶 1 的底物 (PON1)。
T26545	Acanthoic acid NP1302,NP 1302: NP-1302
	Acanthoic acid is a pimaradiene diterpene isolated from Acanthopanax koreanum with anti-inflammatory activities. Acanthoic acid downregulates LPS-induced IL-1β, IL-6 and TNF-α production in BALF, attenuates lung histopathologic changes, and inhibits infla
T15949	Mahanimbine	AChE	Neuroscience
	Mahanimbine 存在于Murraya koenigii 的根、叶和茎中，是从Murraya koenigii 中的提取的一种具有口服活性的生物碱。Mahanimbine 具有乙酰胆碱酯酶抑制活性，可抑制了高脂肪饮食（HFD）引起的小鼠代谢并发症的发展，对科尼氏分枝杆菌叶对链脲佐菌素诱导的糖尿病大鼠胰腺β细胞组织病理学变化有作用。
TN4582	Moracin T	c-Myc; COX	Cell Cycle/Checkpoint; Immunology/Inflammation; Neuroscience
	Moracin treatment can inhibit the double 12-O-tetradecanoylphorbol 13-acetate (TPA) treatment-induced morphological changes reflecting inflammatory response, including leucocyte infiltration, hyperplasia and cell proliferation; moracin treatment furthermo
TN4585	Moronic acid	HIV Protease; Antifection; HSV	Microbiology/Virology; Proteases/Proteasome
	Moronic acid shows oral therapeutic efficacy in HSV-infected mice and possessed novel anti-HSV activity. It also shows significant anti-HIV activity (EC(50) 186) and was modified to develop more potent anti-AIDS agents. Moronic acid is a new structural lead for anti-EBV drug development, can substantially reduce the numbers of EBV particles produced by the cells after lytic induction. Morolic and moronic acids have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an...
TN4584	Morolic acid	IL Receptor; COX; HIV Protease	Immunology/Inflammation; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Morolic acid and moronic acid have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an insulin sensitization with consequent changes of glucose, cholesterol and triglycerides, in part mediated by inhibition of 11β-HSD 1. Moro
TN4394	Kobophenol A	MMP; BCL; p38 MAPK; NF-κB; ROS; DNA/RNA Synthesis; CDK; JNK	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; MAPK; NF-κB; Proteases/Proteasome
	Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell death. Kobophenol A inhibits AChE activity in a dose-dependent manner, and the IC50 value is

天然产物

Cat.No: T2803

Synonym: 野百合碱,Crotaline

Target: TGF-beta/Smad

Cat.No: TF0083

Cat.No: TN6779

Target: Others

Cat.No: T4732

Synonym: Karnozin,L-肌肽,beta-Alanyl-L-histidine

Target: Antioxidant, Endogenous Metabolite

Cat.No: T10023

Synonym: NSC 9586,Nako TRB,1-萘酚,Furro ER

Target: Endogenous Metabolite

3-Epioleanolic acid

Cat.No: TN1248

Target: AChR

Cat.No: TN7117

Target: Others

DL-Homocysteine thiolactone hydrochloride

Cat.No: T5968

Synonym: DL-Homocysteinethiolactone hydrochloride,DL-高半胱氨酸硫内酯盐酸盐

Target: Endogenous Metabolite

Indole-3-pyruvic acid

Cat.No: T4939

Synonym: 3-(3-吲哚基)-2-氧代丙酸,3-(3-Indolyl)-2-oxopropanoic acid

Target: Others

Cat.No: T5061

Synonym: 7,8-Dimethylalloxazine,光色素

Target: Others

N-Nitrosodiethylamine

Cat.No: T35455

Synonym: Diethylnitrosamine,NDEA

Target: DNA/RNA Synthesis

(E)-Naringenin chalcone

Cat.No: T2S2173

Synonym: Isosalipurpol,柚皮苷查尔酮,Chalconaringenin,trans-2'4'6'4-tetrahydroxychalcone,柚皮素查耳酮

Target: Others

4-aminobenzoic acid

Cat.No: T1311

Synonym: PABA,Vitamin H1,Vitamin Bx,para-Aminobenzoic acid,对氨基苯甲酸

Target: Endogenous Metabolite

1,4-D-Gulonolactone

Cat.No: T4719

Synonym: D-Gulonic acid γ-lactone,D-(-)-古洛糖酸-1,4-内酯

Target: Others, Endogenous Metabolite

Cat.No: T8098

Synonym: γ-caprolactone,gamma-己内酯,γ-己内酯

Target: Others

Cat.No: T26545

Synonym: NP1302,NP 1302: NP-1302

Cat.No: T15949

Target: AChE

Cat.No: TN4582

Target: c-Myc, COX

Cat.No: TN4585

Target: HIV Protease, Antifection, HSV

Cat.No: TN4584

Target: IL Receptor, COX, HIV Protease

Cat.No: TN4394

Target: MMP, BCL, p38 MAPK, NF-κB, ROS, DNA/RNA Synthesis, CDK, JNK

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