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59

抑制剂 & 化合物

16

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T5458	Darusentan Lu-135252,达卢生坦	Endothelin Receptor	GPCR/G Protein
	Darusentan (Lu-135252) 是内皮素受体 A (ET-A) 受体选择性拮抗剂，能够作用于 ET-A 受体(Ki:1.4 nM)及ET-B 受体(Ki:184 nM)，对 ETA 受体的选择性大于 ETB 受体的100以上。它在大鼠主动脉血管平滑肌细胞膜中竞争结合放射性标记的内皮素(Ki:13 nM)。
TQ0003	740 Y-P 740YPDGFR,PDGFR 740Y-P	PI3K; Autophagy	Autophagy; PI3K/Akt/mTOR signaling
	740 Y-P (740YPDGFR) 是一个细胞渗透性PI3K 激活剂。它能结合含有 p85 的 N- 和 C- 末端 SH2 结构域的 GST 融合蛋白。
T3965	Fevipiprant QAW039,NVP-QAW039,非维匹仑	GPR; Prostaglandin Receptor	Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation
	Fevipiprant (NVP-QAW039) 是一种选择性、强效、可逆的竞争性 CRTh2 拮抗剂，KD 值为1.1 nM，IC50为0.44 nM，能够引发人体嗜酸性粒细胞的形状变化。
T6991	Nitroprusside disodium dihydrate 硝普钠二水合物,硝普钠,Sodium Nitroferricyanide(III) Dihydrate,Sodium Nitroprusside Dihydrate	Guanylate cyclase; Autophagy	Autophagy; GPCR/G Protein
	Nitroprusside disodium dihydrate (Sodium Nitroprusside Dihydrate) 是一种血管扩张剂，通过在血液中自发释放 NO 发挥作用。它可在谷胱甘肽耗竭的成骨细胞中诱导自噬，用于急性高血压和心力衰竭的研究。
T10101	Calcium channel-modulator-1	Others; Calcium Channel	Membrane transporter/Ion channel; Metabolism; Others
	Calcium channel-modulator-1是钙离子通道调节剂(IC50:0.8 μM)，具有阻塞主动脉收缩的专业化。
T33868	Palmitoyl glutamic acid N-Palmitoyl-L-glutamic acid,Palmitoylglutaminic acid
	Palmitoyl glutamic acid (N-Palmitoyl-L-glutamic acid) 是一种酰基氨基酸，可阻断主动脉收缩,可拮抗由氟哌啶醇诱发的口腔运动障碍。Palmitoyl glutamic acid 常常添加在化妆品中。
TQ0057	AVE 0991	Others	Others
	AVE 0991 是血管紧张素-(1-7) [Ang-(1-7)] 的非肽类似物，是一种具有口服活性的 Mas 激动剂，对 [125I]-Ang-(1-7) 结合到牛主动脉内皮细胞膜有抑制作用，通过增强自噬来抑制星形胶质细胞介导的阿尔茨海默病神经炎症。
T62893	SM-2470	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	SM-2470 是一种α1-adrenoceptor拮抗剂，具有降压活性，可减低前神经节肾上腺神经活性和主动脉降压神经活性。SM-2470 具有降胆固醇活性，可抑制胆固醇吸收。
T11598	IAXO-102	TLR	Immunology/Inflammation
	IAXO-102 是一种 TLR4 拮抗剂，可负向调节 TLR4 信号传导，还可以防止实验性腹主动脉瘤的发展。它抑制 MAPK 和 p65 NF-κB 磷酸化和 TLR4 依赖性促炎蛋白的表达。
T11076	Dooku1	Others	Others
	Dooku1 是Yoda1 的类似物，是一种内源性Piezo1通道的选择性拮抗剂，能够抑制Yoda1 诱导的主动脉舒张。它在HEK 293 细胞以及HUVEC 中测得对2 μM Yoda1 诱导的钙离子流的IC50值分别为1.3 μM 和1.5 μM。
T7284	Argipressin acetate (113-79-1(free base))	Others	Others
	Vasopressin acetate (113-79-1(free base)) 是一种具有血管收缩和抗利尿活性的肽激素，可与血管精氨酸加压素受体 V1 结合，在 A7r5 大鼠主动脉平滑肌细胞和新生大鼠心肌细胞中的 Kd 值分别为 1.31 和 1.44 nM。
T30140	Arotinolol hydrochloride Arotinolol HCl	5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Arotinolol hydrochloride（Arotinolol HCl）是一种非选择性的 α/β-肾上腺素受体 (α/β-adrenergic receptor ) 阻滞剂。Arotinolol hydrochloride 对放射性配体 125I-ICYP 与 5HT1B-羟色胺受体能结合有抑制作用。Arotinolol hydrochloride 是一种抗高血压和抗肥胖试剂，可改善大鼠主动脉僵硬，研究肥胖相关疾病。
T68123	Oxodipine	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Oxodipine 是一种二氢吡啶型钙拮抗剂，抑制了KCl 诱导的兔主动脉收缩，降低了效力较低的大鼠心室试纸收缩的心脏力量。在大鼠培养的新生儿心室肌细胞中，Oxodipine 降低了L 型Ca 电流（I），IC 为0.24μM，对T 型Ca 电流（I）的IC 为0.41μM。Oxodipine 会使小鼠便秘和狗牙龈增生。
T33440	MK785 MK-785,MK 785
	MK785 is part of the association between inhibition of aortic histamine formation, aortic albumin permeability, and atherosclerosis. Aortic histamine synthesis was inhibited by partial inhibition of aortic histidine decarboxylase (HD) by application of MK
T32406	KMUP-4 KMUP 4
	Kmup-4 is an enhancer of cGMP activity and an aortic smooth muscle relaxant.
T32405	KMUP-3 KMUP 3,KMUP3
	KMUP-3 is an enhancer of cGMP activity, and acts as an aortic smooth muscle relaxant.
T28779	SIM-6080
	SIM-6080 is a calcium channel antagonist. SIM-6080 inhibits the proliferation of rat aortic myocytes.
T25946	Phenyl butyrate AI311761,AI3 11761,AI3-11761
	Phenyl butyrate is a non-selective ERS inhibitor that attenuates angiotensin II-induced abdominal aortic aneurysm.
T3580L	FIPI HCl FIPI hydrochloride,FIPI
	FIPI is an effective and selective phospholipase D inhibitor that reduces mercury-induced lipid signaling and thus protects aortic endothelial cells from cytotoxicity.
T32426	KT 1 KT-1,KT1
	KT 1 decreased aortic pressure, renal blood flow, left ventricular enddiastolic pressure and resistances of total peripheral, vertebral, coronary and renal vasculatures and increased aortic blood flow, vertebral blood flow, coronary blood flow, peak posit
T81782	mLR12
	mLR12为Trem1抑制肽，能显著降低BAPN诱导的胸主动脉瘤及夹层(TAAD)小鼠模型中的主动脉破裂率。
T28487	Quininib
	Quininib is a regulator of Ocular Angiogenesis. Quininib significantly inhibits angiogenic tubule formation in HMEC-1 cells, angiogenic sprouting in aortic ring explants and retinal revascularisation in OIR mice.
T27347	Fonsartan free acid HR720,HOE720,HR-720,HOE-720
	Fonsartan is an angiotensin receptor antagonist. Fonsartan inhibits the angiotensin II-induced trophic effects, fibronectin release and fibronectin-EIIIA+ expression in rat aortic vascular smooth muscle cells in vitro.
T14354	AVE 0991 sodium salt	Others	Others
	AVE 0991 competes for high-affinity binding of [125I]-Ang-(1-7) to bovine aortic endothelial cell membranes, with IC50 of 21±35 nM. AVE 0991 sodium salt is a nonpeptide and orally active Ang-(1-7) receptor Mas agonist.
T27325	FK-739 free acid FK-739,FK 739,FK739
	FK-739 is an angiotensin type 1 receptor antagonist. FK 739 inhibits the specific binding of [125I]-angiotensin II to rat aortic smooth muscle cell membrane (IC50 = 8.6 nM) without displacing the specific binding of [125I]-angiotensin II to bovine cerebel
T70280	KB-R7785
	KB-R7785 is a novel ADAM12 and MMP inhibitor, ameliorating cardiac function in a transverse aortic constriction (TAC) model by inhibiting the proteolytic activation of HB-EGF signaling, exerting its antidiabetic effect by ameliorating insulin sensitivity through the inhibition of TNF-alpha production.
T36198	Avenanthramide-C methyl ester
	Avenanthramide-C methyl ester is an inhibitor of NF-κB activation that acts by blocking the phosphorylation of IKK and IκB (IC50 ~ 40 μM). Through this mechanism, avenanthramide-C methyl ester dose dependently inhibits the expression and secretion of IL-6, IL-8, and MCP-1 in human aortic endothelial cells.
T17189	U-46619 9,11-Methanoepoxy PGH2	Progesterone Receptor; PPAR	DNA Damage/DNA Repair; Metabolism; Others
	U-46619是一种有效的TXA2激动剂，是一种血栓素A2类似物（内过氧化物），有诱导肌球蛋白轻链9 (Myl9)基因缺失小鼠主动脉平滑肌(SM)收缩的功能。
TP1620	Cyclic MKEY
	MKEY, a synthetic cyclic peptide inhibitor of CXCL4-CCL5 heterodimer formation, has been shown to protect against atherosclerosis and aortic aneurysm formation by mediating inflammation, but whether it modulates neuroinflammation and brain injury has not
T26665	AS604872 AS-604872,AS 604872
	AS604872 is a selective antagonist of the FP receptor.. AS604872 significantly accelerated degeneration of the media in both cerebral artery and aorta as evidenced by thinning of the media and disruption of the elastic lamina and promoted IA and aortic di
T37459	Lipoxin A5
	Lipoxin A5 (LXA5) is produced by enzymatic transformation of EPA by leukocytes. LXA5 slowly contracts pulmonary parenchymal strips from guinea pig with similar potency to that of LXA4 and LXB4. However, LXA5 does not exert the vasodilatory effects on aortic smooth muscle exhibited by LXA4 and LXB4.
T7434	Argipressin Arg8-vasopressin,Vasopressin,醋酸精氨酸加压素,精氨加压素,AVP	Vasopressin Receptor	GPCR/G Protein
	Argipressin (Vasopressin) 是一种具有血管收缩和抗利尿活性的肽激素，可与血管精氨酸加压素受体 V1 结合，在 A7r5 大鼠主动脉平滑肌细胞和新生大鼠心肌细胞中的 Kd 值分别为 1.31 和 1.44 nM。
T78011	Cyclic MKEY TFA
	Cyclic MKEY TFA为CXCL4-CCL5异二聚体的合成环肽抑制剂，可通过调控炎症反应预防动脉粥样硬化和主动脉瘤。此外，该化合物亦能阻止小鼠中风后脑损伤的发生。
T28321	PD 122860 PD-122860,PD122860
	PD 122860 is a dihydropyridine with calcium channel blocking and sodium channel stimulating properties. In the rat heart, PD 122860 increased left ventricular contractility, decreased coronary resistance and altered the shape of the electrocardiogram T-wa
T27351	Fostedil KB-944,KB944,A 53986,KB 944,A-53986,BRN 3626546
	Fostedil is a calcium channel antagonist. KB-944 increased regional segment function in normal and ischemic regions and maintained distal coronary artery perfusion pressure, coronary flow and transmural regional myocardial blood flow during partial corona
T73645	ARL67156 triethylamine
	ARL67156 (FPL 67156) triethylamine 是一种ecto-ATPase 抑制剂。ARL67156 triethylamine 是竞争性 NTPDase1 (CD39)，NTPDase3 和 NPP1 抑制剂，Ki 分别为 11，18 和 12 μM。ARL67156 triethylamine 可用于钙化性主动脉瓣疾病、哮喘等疾病的研究。
T21814	ONO 4817
	ONO-4817 是一种广谱基质金属蛋白酶 (MMP) 抑制剂。抑制基质金属蛋白酶 (MMP) 有望抑制动脉粥样硬化新内膜增殖，从而限制动脉粥样硬化斑块的进展。ONO-4817 抑制实验性高脂血症兔主动脉内膜增生的发展。
T60832	(S)-Bromoenol lactone
	(S)-Bromoenol lactone ((S)-BEL) 以 2 μM 的IC50值抑制大鼠主动脉平滑肌（A10）细胞中血管加压素诱导的花生四烯酸的释放。(S)-Bromoenol lactone 是一种不可逆的、手性的、基于机制的钙非依赖性磷脂酶A2β (iPLA2β) 抑制剂。
T35943	15(S)-HpETE
	15(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of 15-lipoxygenase (15-LO) on arachidonic acid. It is either metabolized to 14,15-leukotriene A4 [1] or reduced to 15(S)-HETE by peroxidases.[2] [1] 15(S)-HpETE mediates a number of biological functions including the induction of c-fos and c-jun, and activation of AP-1. [3] 15(S)-HpETE inhibits prostacyclin synthesis in porcine aortic microsomes and bovine endothelial cells, and can cause the suicide inac...
T73644	ARL67156 trisodium hydrate
	ARL67156 (FPL 67156) trisodium hydrate 是一种ecto-ATPase 抑制剂。ARL67156 trisodium hydrate 是竞争性 NTPDase1 (CD39)，NTPDase3 和 NPP1 抑制剂，Ki 分别为 11，18 和 12 μM。ARL67156 trisodium hydrate 可用于钙化性主动脉瓣疾病、哮喘等疾病的研究。
T74778	ASM-IN-1	Phospholipase	Metabolism
	ASM-IN-1是一种高效的口服活性ASM抑制剂，具有1.5 µM的IC50值。该化合物在减少主动脉弓及主动脉的脂质斑块方面表现出效果，并能够降低血浆中的神经酰胺以及Ox-LDL水平。ASM-IN-1展现了抗动脉粥样硬化与抗炎的活性。
T71870	CP21
	CP21 is an iron chelator that binds to iron in a 3:1 (ligand:iron) ratio. It is active against P. falciparum when used at concentrations of 10 and 100 µM. CP21 inhibits production of prostaglandin I2 induced by epinephrine, arachidonic acid, or A23187 in isolated rat aortic rings with IC50 values of 1.3, 1.3, and 1.4 mM, respectively. It inhibits glutamate-induced oxytosis, as well as decreases iodoacetic acid-induced cytotoxicity in an in vitro model of ischemia, in HT22 mouse hippocampal cells...
T35987	CAY10563 CAY10563
	S-Nitrosothiols (RSNOs) are a class of molecules that function as exogenous and endogenous nitric oxide (NO) donors. RSNOs found in vivo include proteins such as S-nitrosohemoglobin and S-nitrosoalbumin, as well as low molecular weight species such as S-nitrosoglutathione (GSNO) and S-nitrosocysteine (CysNO). CAY10563 is a member of a new class of S-nitrosothiol species that act as an NO donors under acidic conditions. It decomposes with a half-life of one minute in 0.1 M phosphate buffer, pH 5....
T36601	(±)17-HDHA
	(±)17-HDHA is an autoxidation product of docosahexaenoic acid in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. 17(S)-HDHA could be produced by enzymatic oxidation of DHA using soybean lipoxygenase (LO) and is the putative product of mammalian 15-LOs. 17(S)-HDHA was shown to be an inhibitor of U-46619 -induced rabbit and rat aortic smooth muscle contraction with IC50 values of 4.9 and 7.2 μM, respectively. (±)17-HDHA is a potential marker of ox...
T35988	CAY10564
	S-Nitrosothiols (RSNOs) are a class of molecules that function as exogenous and endogenous nitric oxide (NO) donors. RSNOs found in vivo include proteins such as S-nitrosohemoglobin and S-nitrosoalbumin, as well as low molecular weight species such as S-nitrosoglutathione (GSNO) and S-nitrosocysteine (CysNO). CAY10564 is a member of a new class of S-nitrosothiol species that act as NO donors under acidic conditions. It decomposes with a half-life of one minute in 0.1 M phosphate buffer, pH 5.0, ...
T35505	(±)11-HDHA
	(±)11-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. DHA is metabolized to 11(S)-HDHA by human platelets and canine retina. In addition to 11(S)-HDHA, 14(S)-HDHA is also produced by platelets. 11(S)-HDHA was shown to be an inhibitor of U-46619-induced human platelet aggregation and rabbit and rat aortic smooth muscle contraction with IC50 values of about 50, 4.7, and 7.5 μM, respe...
T35989	CAY10565
	S-Nitrosothiols (RSNOs) are a class of molecules that function as exogenous and endogenous nitric oxide (NO) donors. RSNOs found in vivo include proteins such as S-nitrosohemoglobin and S-nitrosoalbumin, as well as low molecular weight species such as S-nitrosoglutathione (GSNO) and S-nitrosocysteine (CysNO). CAY10565 is a member of a new class of S-nitrosothiol species that act as NO donors under acidic conditions. It decomposes with a half-life of 130 minutes in 0.1 M phosphate buffer, pH 5.0,...
T35509	(±)14-HDHA
	(±)14-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. DHA is metabolized to 14(S)-HDHA by human platelets along with 11(S)-HDHA. 14(S)-HDoHE is also produced by salmon gills upon stimulation with calcium ionophore. 14(S)-HDHA was shown to be an inhibitor of U-46619-induced human platelet aggregation and rabbit and rat aortic smooth muscle contraction with IC50 values of about 70, 3...
TP2097	ELA-32(human) ELA-32 (human)
	Potent, high affinity apelin receptor agonist (IC50 = 0.27 nM; Kd = 0.51 nM). Exhibits no binding GPR15 and GPR25. Activates the PI3K/AKT pathway and promotes self-renewal of hESCs via cell-cycle progression and protein translation. Also potentiates the T
T36235	5-Chlorouracil
	5-Chlorouracil is a chlorinated derivative of the pyrimidine nucleoside base uracil . In vivo, it is converted into chlorodeoxyuridine, which is mutagenic and genotoxic.1 Uracil is chlorinated at the 5 position in a cell-free myeloperoxidase, peroxide, and chloride system in which hypochlorous acid is formed.2 5-Chlorouracil has been found in human neutrophils stimulated with phorbol 12-myristate 13-acetate in vitro and in inflammatory human exudate isolated from sites of superficial infection. ...

化合物

Cat.No: T5458

Synonym: Lu-135252,达卢生坦

Target: Endothelin Receptor

Cat.No: TQ0003

Synonym: 740YPDGFR,PDGFR 740Y-P

Target: PI3K, Autophagy

Cat.No: T3965

Synonym: QAW039,NVP-QAW039,非维匹仑

Target: GPR, Prostaglandin Receptor

Nitroprusside disodium dihydrate

Cat.No: T6991

Synonym: 硝普钠二水合物,硝普钠,Sodium Nitroferricyanide(III) Dihydrate,Sodium Nitroprusside Dihydrate

Target: Guanylate cyclase, Autophagy

Calcium channel-modulator-1

Cat.No: T10101

Target: Others, Calcium Channel

Palmitoyl glutamic acid

Cat.No: T33868

Synonym: N-Palmitoyl-L-glutamic acid,Palmitoylglutaminic acid

Cat.No: TQ0057

Target: Others

Cat.No: T62893

Target: Adrenergic Receptor

Cat.No: T11598

Target: TLR

Cat.No: T11076

Target: Others

Argipressin acetate (113-79-1(free base))

Cat.No: T7284

Target: Others

Arotinolol hydrochloride

Cat.No: T30140

Synonym: Arotinolol HCl

Target: 5-HT Receptor, Adrenergic Receptor

Cat.No: T68123

Target: Calcium Channel

Cat.No: T33440

Synonym: MK-785,MK 785

Cat.No: T32406

Synonym: KMUP 4

Cat.No: T32405

Synonym: KMUP 3,KMUP3

Cat.No: T28779

Phenyl butyrate

Cat.No: T25946

Synonym: AI311761,AI3 11761,AI3-11761

Cat.No: T3580L

Synonym: FIPI hydrochloride,FIPI

Cat.No: T32426

Synonym: KT-1,KT1

Cat.No: T81782

Cat.No: T28487

Fonsartan free acid

Cat.No: T27347

Synonym: HR720,HOE720,HR-720,HOE-720

AVE 0991 sodium salt

Cat.No: T14354

Target: Others

FK-739 free acid

Cat.No: T27325

Synonym: FK-739,FK 739,FK739

Cat.No: T70280

Avenanthramide-C methyl ester

Cat.No: T36198

Cat.No: T17189

Synonym: 9,11-Methanoepoxy PGH2

Target: Progesterone Receptor, PPAR

Cat.No: TP1620

Cat.No: T26665

Synonym: AS-604872,AS 604872

Cat.No: T37459

Cat.No: T7434

Synonym: Arg8-vasopressin,Vasopressin,醋酸精氨酸加压素,精氨加压素,AVP

Target: Vasopressin Receptor

Cyclic MKEY TFA

Cat.No: T78011

Cat.No: T28321

Synonym: PD-122860,PD122860

Cat.No: T27351

Synonym: KB-944,KB944,A 53986,KB 944,A-53986,BRN 3626546

ARL67156 triethylamine

Cat.No: T73645

Cat.No: T21814

(S)-Bromoenol lactone

Cat.No: T60832

Cat.No: T35943

ARL67156 trisodium hydrate

Cat.No: T73644

Cat.No: T74778

Target: Phospholipase

Cat.No: T71870

Cat.No: T35987

Synonym: CAY10563

Cat.No: T36601

Cat.No: T35988

Cat.No: T35505

Cat.No: T35989

Cat.No: T35509

Cat.No: TP2097

Synonym: ELA-32 (human)

Cat.No: T36235

Cat. No.	Product Name	Target	Signaling Pathways
TN1969	N-(p-Coumaroyl) serotonin	PDGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	N-(p-Coumaroyl) Serotonin 是从红花种子中分离出来的多酚，具有抗氧化、抗动脉粥样硬化和抗炎作用，常用于动脉粥样硬化的研究。它可改善动脉粥样硬化和主动脉壁膨大。它可降低肌浆网中 PDGF 诱导的对中PDGFR 酪氨酸磷酸化和 Ca2+释放的作用。
T7437	3-(3-Hydroxyphenyl)propionic Acid m-Hydroxyphenylpropionic acid,3-Hydroxyhydrocinnamic acid,3-(3-羟基苯基)丙酸	Others; Endogenous Metabolite	Metabolism; Others
	3-(3-Hydroxyphenyl)propionic Acid (m-Hydroxyphenylpropionic acid) 是一种黄酮类代谢产物，由人体微生物区系形成，具有舒张血管的特性。
T13475	β-Aminopropionitrile 3-氨基丙腈,3-Aminopropionitrile,BAPN	Others; Endogenous Metabolite	Metabolism; Others
	β-Aminopropionitrile (3-Aminopropionitrile) 是赖氨酰氧化酶的特异性抑制剂。
T6102	2'-acetylacteoside	Antioxidant; Reductase	Endocrinology/Hormones; Metabolism; oxidation-reduction
	2'-Acetylacteoside 是一种苯乙醇苷类化合物，分离自来江藤中，可抑制自由基诱导的红细胞溶血，具有清除自由基的作用。
TN1724	Harmalol hydrochloride Harmidol hydrochloride	P450; Antioxidant	Metabolism; oxidation-reduction
	Harmalol hydrochloride (Harmidol hydrochloride) 是一种可从Peganum harmala L.的种子中提取出来的β-咔啉生物碱。Harmalol hydrochloride 是Harmaline 的主要代谢产物，在转录和翻译后水平上显著抑制二恶英介导的 CYP1A1 诱导。Harmalol hydrochloride 在去氧肾上腺素或KCl 预先收缩的分离大鼠胸主动脉制剂中显示出血管松弛活性。 Harmalol hydrochloride 具有抗氧化活性.
TN1338	7Beta-Hydroxycholesterol	LDL; Calcium Channel; MAPK	MAPK; Membrane transporter/Ion channel; Metabolism
	7beta-Hydroxycholesterol, a major cytotoxin in oxidized LDL, induces Ca(2+) oscillations, MAP kinase activation and apoptosis in human aortic smooth muscle cells.
TN1246	3-Deoxysappanone B	Others	Others
	3-Deoxysappanone B has vasorelaxation effects, it can mediate endothelium- independent vasodilator action in rat thoracic aortic rings.
TN3904	Dysolenticin J	Others	Others
	Dysolenticin J shows significant vasodilative effects on intact rat aortic rings with a diastolic degree of 87.4% at 10 ug/mL.
T37232	(+)-Geodin
	(+)-Geodin is a fungal metabolite. It increases the fibrinolytic activity of bovine aortic endothelial cells (BAECs) when used at concentrations ranging from 50 to 150 μM. (+)-Geodin (1-100 μg/ml) also increases 2-deoxyglucose uptake by rat adipocytes.
TN5608	Paspalinine
	Paspalinine can inhibit binding of [125I]charybdotoxin (ChTX) to maxi-K channels in bovine aortic smooth muscle sarcolemmal membranes. Paspalinine shows tremorgenic action, which may be due in part to their inhibition of GABAA receptor function.
TN4639	Neolitsine	Others	Others
	Neolitsine has anthelmintic activity, it exhibits EC90 values (concentration at which 90% loss of larval motility is observed) of 6.4 microg/mL.Neolitsine and dicentrine have potent vasorelaxing effects on precontracted rat aortic preparations with mean IC 50 values between 0.08 and 2.48 microM.
TN2075	Pimaric acid	MMP; p38 MAPK; NF-κB	MAPK; NF-κB; Proteases/Proteasome
	Pimaric acid has potent anti-atherosclerotic activity with inhibitory action on matrix metalloproteinase-9 production and cell migration in TNF-α±-induced human aortic smooth muscle cells.
T81324	Quercetin-3-O-(2′′-O-galloyl)-β-D-glucopyranoside
	Quercetin-3-O-(2′′-O-galloyl)-β-D-glucopyranoside 是一种从天竺葵属植物中分离的酚类化合物，具有口服活性和抗炎特性，可能在治疗水肿和改善主动脉内皮依赖性舒张损伤方面有应用潜力。
TN2553	1-Methyl-2-undecyl-4(1H)-quinolone 1-Methyl-2-undecylquinolin-4(1H)-one	MAO	Metabolism; Neuroscience
	1-Methyl-2-undecyl-4(1H)-quinolone, and dihydroevocarpine should also be served as the chemical markers together with evodiamine for the quality control of Evodia rutaecarpa (Juss.) Benth. 1-Methyl-2-undecyl-4(1H)-quinolone shows a selective inhibition of type B MAO (MAO-B) activity with the IC(50) value of 15.3 microM using a substrate kynuramine, but does not inhibit type A MAO (MAO-A) activity.It can mitigate high phosphate-induced human aortic valve interstitial cells (HAVICs) calcification ...
T36227	Beauveriolide III
	Beauveriolide III is a cyclodepsipeptide that has been found inBeauveriaand an inhibitor of lipid droplet formation.1It inhibits lipid droplet formation when used at concentrations of 3 and 10 μM, as well as inhibits cholesterol synthesis (IC50= 0.41 μM), in primary mouse peritoneal macrophages.1,2Beauveriolide III also inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in mouse macrophage membranes (IC50= 5.5 μM).2Beauveriolide III (25 and 50 mg/kg) reduces the size of aortic ...
T83915	Norbixin hydrate
	Norbixin是一种在B. orellana中发现的类胡萝卜素，具有多样的生物活性。在无细胞测试中，它与过氧化物酶体增殖物激活受体γ (PPARγ)结合（Ki = 1.15 µM）。在心脑血管代谢综合征大鼠模型中，Norbixin (47.7 mg/kg) 能够减轻高血糖、高胰岛素血症和胰岛素抗性，降低血清脂质水平及心脏中硫代巴比妥酸反应性物质（TBARS）和谷胱甘肽（GSH）的水平。在胆固醇诱导的动脉粥样硬化兔模型中，它降低氧化型LDL和主动脉蛋白氧化水平，并减少动脉粥样硬化面积。Norbixin（每天0.1和1 mg/kg）减少汞诱导的大鼠肝细胞和白细胞DNA损伤。此外，它还能预防与年龄相关的黄斑变性（AMD）Abca4-/- Rdh8-/-小鼠模型中的光感受器退化。

天然产物

N-(p-Coumaroyl) serotonin

Cat.No: TN1969

Target: PDGFR

3-(3-Hydroxyphenyl)propionic Acid

Cat.No: T7437

Synonym: m-Hydroxyphenylpropionic acid,3-Hydroxyhydrocinnamic acid,3-(3-羟基苯基)丙酸

Target: Others, Endogenous Metabolite

β-Aminopropionitrile

Cat.No: T13475

Synonym: 3-氨基丙腈,3-Aminopropionitrile,BAPN

Target: Others, Endogenous Metabolite

2'-acetylacteoside

Cat.No: T6102

Target: Antioxidant, Reductase

Harmalol hydrochloride

Cat.No: TN1724

Synonym: Harmidol hydrochloride

Target: P450, Antioxidant

7Beta-Hydroxycholesterol

Cat.No: TN1338

Target: LDL, Calcium Channel, MAPK

3-Deoxysappanone B

Cat.No: TN1246

Target: Others

Cat.No: TN3904

Target: Others

Cat.No: T37232

Cat.No: TN5608

Cat.No: TN4639

Target: Others

Cat.No: TN2075

Target: MMP, p38 MAPK, NF-κB

Quercetin-3-O-(2′′-O-galloyl)-β-D-glucopyranoside

Cat.No: T81324

1-Methyl-2-undecyl-4(1H)-quinolone

Cat.No: TN2553

Synonym: 1-Methyl-2-undecylquinolin-4(1H)-one

Target: MAO

Beauveriolide III

Cat.No: T36227

Norbixin hydrate

Cat.No: T83915

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