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Search Results for " antimetabolite "

75

抑制剂 & 化合物

21

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T13621	CNDAC hydrochloride	Nucleoside Antimetabolite/Analog; Others; Drug Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others
	CNDAC hydrochloride 是一种核苷类似物，是沙帕他滨的代谢物。
T7351	3-Methylcytidine	Nucleoside Antimetabolite/Analog	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	3-Methylcytidine 是一种尿核苷，作为四种不同类型癌症的生物标志物：肺癌、胃癌、结肠癌和乳腺癌。
T9726	2’-OMe-Guanosine	Apoptosis; Nucleoside Antimetabolite/Analog	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	2'-O-Methylguanosine 是一种修饰核苷，是tRNA 上的核苷在 tRNA 鸟苷-2’-o-甲基转移酶作用下产生的。2'-O-Methylguanosine 具有一定的促凋亡作用。
T7545	6-Aminonicotinamide	Others	Others
	6-Aminonicotinamide 是一种竞争性 NADP+依赖性酶，是一种烟酰胺抗代谢药，葡萄糖 6-磷酸脱氢酶抑制剂 (Ki=0.46 μM)。它干扰糖酵解，导致 ATP 耗竭，并与 DNA 交联化学疗法药物，如Cisplatin，协同杀死癌细胞。
T7491	6-O-Methyl Guanosine	Nucleoside Antimetabolite/Analog	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	6-O-Methyl Guanosine 是一种修饰核苷，有抑制恶性干皮病细胞系的集落形成能力。
T15235	Enocitabine	Nucleoside Antimetabolite/Analog; HCV Protease; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	Enocitabine 是一种核苷类似物，抑制 DNA 复制剂。Enocitabine 抑制人巨细胞病毒的复制，显示出抗白血病和抗病毒活性。
T13659	DMTr-LNA-5MeU-3-CED-phosphoramidite	Nucleoside Antimetabolite/Analog	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	DMTr-LNA-5MeU-3-CED-phosphoramidite 是核苷的衍生物。
T9727	2'-Fluoro-2'-Deoxyadenosine	Nucleoside Antimetabolite/Analog	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	2′-Deoxy-2′-fluoroadenosine 可用于合成2 ' -脱氧-2 ' -氟修饰的寡核苷酸。它能被大肠杆菌嘌呤核苷磷酸化酶（PNP）有效地分解成毒性物 2-氟腺嘌呤，对表达大肠杆菌 PNP 的肿瘤表现出良好的体内活性。
T8354	Triazavirin	Nucleoside Antimetabolite/Analog; Influenza Virus; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Triazavirin 是一种核酸的核苷类似物和抗病毒剂，通过抑制病毒 RNA 和 DNA 的合成以及基因组片段的复制而起作用。在流感传播阶段，它可作为保护剂。
T1307	Carmofur HCFU,卡莫氟	Nucleoside Antimetabolite/Analog; Virus Protease; SARS-CoV; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Carmofur (HCFU) 是 5-氟尿嘧啶的衍生物，是一种抗肿瘤药物。它是一种酸性神经酰胺酶抑制剂，用于治疗乳腺癌和结直肠癌。它抑制 SARS-CoV-2主要蛋白酶，还抑制 Vero E6 细胞 SARS-CoV-2，EC50为 24.3 μM。
T36756	DMT-dG(ib) Phosphoramidite	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	DMT-dG(ib) Phosphoramidite 可用于 DNA 的合成。
T8648	6-AZATHYMINE	Nucleoside Antimetabolite/Analog; Influenza Virus; DNA/RNA Synthesis; Antibacterial	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	6-Azathymine 是胸腺嘧啶的 6-氮类似物，是 D-3-氨基异丁酸酯-丙酮酸氨基转移酶抑制剂，具有抗菌和抗病毒活性，可抑制DNA 的生物合成。
T0964	Floxuridine 氟尿苷,5-Fluorouracil 2'-deoxyriboside,FUDR,Deoxyfluorouridine,NSC 27640	Apoptosis; Nucleoside Antimetabolite/Analog; Others; DNA/RNA Synthesis; Antibacterial; HSV	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
	Floxuridine (FUDR) 是一种嘧啶类似物，也是一种抗肿瘤代谢物。它抑制胸苷酸合成酶，导致 DNA 合成中断和细胞毒性。它是一种可诱导细胞凋亡的金黄色葡萄球菌感染抑制剂，具有抗HSV 和CMV 病毒的作用。
T19464	N6,N6-Dimethyladenosine N6,N6-二甲基腺苷	Nucleoside Antimetabolite/Analog	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	N6,N6-Dimethyladenosine 是存在于牛分枝杆菌 tRNA 中的一种修饰核糖核苷
T40686	Tiazofurin NSC 286193,Riboxamide,噻唑呋林	Dehydrogenase	Metabolism
	Tiazofurin (NSC-286193) 是一种合成的核苷类似物，显示出抗肿瘤活性。它在细胞内合成为 tiazole-4-carboxamide adenine dinucleotide (TAD)，TAD 可有效抑制 IMP 脱氢酶。
T4061	LY2334737	Nucleoside Antimetabolite/Analog; Others; Virus Protease	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
	LY2334737 是一种具有口服活性的 Gemcitabine 的前药，也是核苷类似物。它抑制肠道病毒 A71 感染，有抗病毒和抗癌活性。
T8380	Bendamustine SDX105,宾达氮芥	Apoptosis; Others; DNA Alkylator/Crosslinker	Apoptosis; DNA Damage/DNA Repair; Others
	Bendamustine (SDX105) 是一种嘌呤类似物，是一种 DNA 交联剂，具有烷基化、抗癌和抗代谢作用。它可激活 DNA 损伤反应和细胞凋亡。
T16911	Sorivudine BV-araU,索立夫定	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Sorivudine (BV-araU) 是口服有效的，嘧啶核苷抗代谢药物。它的抗病毒活性来自某些 DNA 病毒中存在的特定胸苷激酶选择性转化为核苷酸，从而反过来会干扰病毒 DNA 合成。
T2366	Tipiracil hydrochloride MA-1 hydrochloride,盐酸替吡嘧啶	Nucleoside Antimetabolite/Analog	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Tipiracil hydrochloride (MA-1 hydrochloride) 是一种胸苷磷酸化酶抑制剂，是抗癌候选药物 TAS-102 中的活性成分之一，用于癌症研究。
T38958	DMT-2′Fluoro-dU Phosphoramidite 2'-F-dU Phosphoramidite	Nucleoside Antimetabolite/Analog	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	DMT-2′Fluoro-dU Phosphoramidite (2'-F-dU Phosphoramidite) 可用于核苷修饰。
T0297	Clofarabine Clofarex,氯法拉滨,克罗拉滨,Evoltra,Clolar	Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Clofarabine (Clofarex) 是一种核糖核苷酸还原酶抑制剂，IC50值为65 nM。它是核苷类似物，可用于癌症研究。
T7621	6-Thioinosine 6-Mercaptopurine riboside,6-疏基嘌呤核苷,6TI	Nucleoside Antimetabolite/Analog	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	6-Thioinosine (6TI) 是一种嘌呤抗代谢物，是抗脂肪形成剂，能降低PPAR γ和C/EBPα及其目标基因 aP2、CD36、LPL 和 LXRα 的 mRNA 水平。
T1120	Dacarbazine Imidazole Carboxamide,达卡巴嗪,DTIC-Dome	Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Dacarbazine (DTIC-Dome) 是一种抗肿瘤剂，对黑色素瘤具有显着的活性。
T6603	Nelarabine GW 506U78,Nelzarabine,奈拉滨,506U78	Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Nelarabine (GW 506U78) 是一种嘌呤核苷酸类似物，为DNA 合成抑制剂，对肿瘤细胞的IC50为0.067-2.15 μM，可作用于T 细胞急性淋巴细胞白血病。
T0010	6-Mercaptopurine 6-巯基嘌呤,乐疾宁,6-MP,Mercaptopurine,6-巯基嘌呤	Nucleoside Antimetabolite/Analog; Others; Dehydrogenase; Endogenous Metabolite; Autophagy	Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others
	6-Mercaptopurine (6-MP) 是一种具有免疫抑制特性的抗代谢物抗肿瘤剂。它通过抑制嘌呤代谢来干扰核酸合成，通常与其他药物联合用于白血病的治疗或缓解维持计划。
T1408	Capecitabine Xeloda,卡培他滨,Capecitibine,Capiibine,RO 09-1978	Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Capecitabine (Capecitibine) 是一种可口服的前药，可由胸苷磷酸化酶催化转变为其活性代谢物 Fluorouracil。
T0251	Gemcitabine 吉西他滨,NSC 613327,LY188011	Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Gemcitabine (LY188011) 是一种人工合成的胞嘧啶核苷衍生物，一种 DNA 合成抑制剂。Gemcitabine 具有抗肿瘤活性和抗代谢活性。Gemcitabine 可以引起细胞自噬和凋亡。
T12399	Peldesine BCX 34	Nucleoside Antimetabolite/Analog; HIV Protease	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	Peldesine (BCX 34) 是一种有效的、竞争性的、可逆的和口服活性的嘌呤核苷磷酸化酶抑制剂。 Peldesine 抑制 T 细胞增殖，IC50 为 800 nM。 Peldesine 可用于皮肤 T 细胞淋巴瘤、牛皮癣和 HIV 感染的研究。
T1378	Tegafur Fluorafur,替加氟,FT-207,NSC 148958,FT 207	Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Tegafur (FT 207) 是一种前药，在肝脏中被细胞色素 P-450 酶逐渐转化为氟尿嘧啶。它是抗代谢物氟尿嘧啶的同源物，具有抗肿瘤活性。
T16813	RX-3117 fluorocyclopentenylcytosine,TV-1360	Nucleoside Antimetabolite/Analog	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	RX-3117 (fluorocyclopentenylcytosine) 是一种新型的胞苷类似物，在几种癌细胞系中显示出抗癌活性，包括对吉西他滨耐药的变体。
T19459	N1-Methylpseudouridine N1-甲基-假尿苷,1-Methylpseudouridine	Others	Others
	N1-Methylpseudouridine (1-Methylpseudouridine) 是一种甲基假尿苷，翻译性能比 5 mC 和 5 mC/N1-Methylpseudouridine 高。通过提高核糖体密度，mRNA 中的 N1-Methylpseudouridine 以 eIF2α 依赖性和独立机制增强翻译。
T40192	dGTP 2′-脱氧鸟苷 5′-(四氢三磷酸酯),2'-Deoxyguanosine-5'-triphosphate	Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	dGTP（2'-Deoxyguanosine-5'-triphosphate）作为脱氧核糖核酸（DNA）合成的基本单元，属于鸟苷核苷酸，对8-O-GDP、8-O-dGTP、8-O-GTP及8-O-dGTP的氧化损伤具有高度敏感性。
T6794	5-BrdU 溴脲苷,BUdR,5-溴脱氧尿嘧啶核苷,Broxuridine,5-bromo-2'-deoxyuridine,Bromodeoxyuridine,BRDU	Nucleoside Antimetabolite/Analog; Others	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others
	5-BrdU (Broxuridine) 是一种核苷类似物，用于检测增殖细胞并与胸苷竞争掺入 DNA。
T1600	Doxifluridine Ro 21-9738,AMC 0101,5'-DFUR,5-Fluoro-5'-deoxyuridine,去氧氟尿苷	Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Doxifluridine (AMC 0101) 是一种胸苷磷酸化酶活化剂，对 PC9-DPE2细胞的 IC50为0.62 μM。它是具有抗肿瘤活性的抗肿瘤剂 5-fluorouracil (5-FU) 的氟嘧啶衍生物和口服前药。
T19214	Bredinin aglycone 5-Hydroxy-1H-imidazole-4-carboxamide,5-羟基-1H-咪唑-4-甲酰胺,SM-108	Others	Others
	Bredinin aglycone (SM-108) 是嘌呤核苷酸类似物，可用于嘌呤核苷酸类似物催化剂的制作效率的检测。
T3658	Trifluridine/tipiracil hydrochloride mixture Trifluridine-tipiracil hydrochloride mixture,TAS102,TAS-102,TAS 102	Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Trifluridine/tipiracil hydrochloride mixture (TAS-102) 是一种新型口服组合药物，含有摩尔比为 2:1 的曲氟尿苷(TFT) 和盐酸替吡嘧啶 (TTP)。它主要通过抑制胸苷酸合酶 (TS) 和掺入 DNA 来显示抗肿瘤活性。
T6632	Raltitrexed ZD1694,雷替曲塞,D1694,ICI-D1694,Tomudex	Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Raltitrexed (D1694) 是一种抗代谢药物，通过抑制胸苷酸合成酶起作用，可用于化疗。
T1038	Fludarabine NSC 118218,Fludarabinum,氟达拉宾,氟达拉滨,F-ara-A	Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; STAT	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; JAK/STAT signaling; Stem Cells
	Fludarabine (Fludarabinum) 是一种氟化嘌呤类似物，一种核酸合成抑制剂和 STAT1 激活抑制剂。Fludarabine 具有抗肿瘤活性，可以用于治疗白血病和淋巴瘤。
T0984	5-Fluorouracil 5-FU,Fluorouracil,5-氟脲嘧啶,NSC 19893,5-Fluoracil,氟尿嘧啶	Apoptosis; Nucleoside Antimetabolite/Analog; HIV Protease; DNA/RNA Synthesis; Endogenous Metabolite	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; Proteases/Proteasome
	5-Fluorouracil (5-FU) 是一种尿嘧啶类似物，一种 DNA 合成抑制剂。5-Fluorouracil 具有抗肿瘤活性，通过抑制胸苷酸合成酶影响嘧啶的合成。5-Fluorouracil 可以引起细胞凋亡和自噬。
T1404	Stavudine d4T,Sanilvudine,BMY-27857,NSC 163661,司他夫定	Apoptosis; Nucleoside Antimetabolite/Analog; HIV Protease; NOD-like Receptor (NLR); Reverse Transcriptase; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Stavudine (BMY-27857) 是一种口服活性核苷逆转录酶抑制剂，还抑制线粒体 DNA 的复制，具有抗HIV-1和HIV-2的活性。它降低 NLRP3 炎症小体激活，调节淀粉样 β 自噬，诱导细胞凋亡。
T7518	Deoxycytidine triphosphate trisodium salt 2'-脱氧胞苷-5'-三磷酸三钠盐,2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE TRISODI	Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; Endogenous Metabolite; Antibiotic	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
	Deoxycytidine triphosphate trisodium salt (2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE TRISODI) 是可用于 DNA 合成的核苷三磷酸，可用于实时荧光定量 PCR、cDNA 合成和 DNA 测序。
T1428	Trifluridine 曲氟尿苷,NSC 529182,Trifluorothymidine,5-Trifluorothymidine,NSC 75520,曲氟胸苷,Viroptic,Trifluridina	Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Trifluridine (NSC-75520) 是一种氟化胸苷类似物，具有潜在的抗肿瘤活性，还具有抗病毒活性。它掺入 DNA 并抑制胸苷酸合酶，从而抑制 DNA 合成、抑制蛋白质合成和细胞凋亡。
T12908	SIBA 5'-Deoxy-5'-isobutylthioadenosine,5'-Isobutylthioadenosine,5ˊ-异丁硫基-5ˊ-脱氧腺苷	Nucleoside Antimetabolite/Analog; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	SIBA (5'-Deoxy-5'-isobutylthioadenosine) 是 SAH 的合成类似物，可作为 S-腺苷甲硫氨酸介导的甲基转移的抑制剂。它干扰多种酶活性，可逆地阻断单纯疱疹病毒 1 型病毒的繁殖。
T6069	Gemcitabine hydrochloride Gemcitabine HCl,吉西他滨盐酸盐,Gemzar,LY188011,盐酸吉西他滨,LY 188011 hydrochloride	Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Gemcitabine hydrochloride (LY 188011 hydrochloride) 是一种人工合成的胞嘧啶核苷衍生物，一种 DNA 合成抑制剂。Gemcitabine 具有抗肿瘤活性和抗代谢活性。Gemcitabine 可以引起细胞自噬和凋亡。
T0095	Bendamustine hydrochloride SDX-105,SDX-105 (Cytostasane) HCl,Bendamustine HCl,EP-3101,盐酸苯达莫司汀	Apoptosis; DNA Alkylator/Crosslinker; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Bendamustine hydrochloride (EP-3101) 是一种嘌呤类似物，是一种 DNA 交联剂。它可激活 DNA 损伤反应和细胞凋亡，有烷基化，抗癌和抗代谢作用。
T0688	Ganciclovir BW 759,更昔洛韦,RS-21592,2'-Nor-2'-deoxyguanosine	Nucleoside Antimetabolite/Analog; Others; Antibiotic; Antifection; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
	Ganciclovir (2'-Nor-2'-deoxyguanosine) 是核苷类似物和口服抗病毒药物，对CMV 具有抗病毒活性。它用于治疗与艾滋病相关的巨细胞病毒感染的并发症。
T2201	6-Mercaptopurine hydrate 6-Mercaptopurine monohydrate,6-巯基嘌呤(一水合物),6-Mercaptopurine (6-MP) Monohydrate,6-巯基嘌呤一水合物	Nucleoside Antimetabolite/Analog; Others; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others
	6-Mercaptopurine hydrate (6-Mercaptopurine monohydrate) 是一种核苷代谢抑制剂。它通过抑制嘌呤代谢来干扰核酸合成，通常与其他药物联合用于白血病的治疗或缓解维持计划。
T6501	Fludarabine Phosphate NSC 312887 Phosphate,fludara Phosphate,F-ara-A (NSC 312887) Phosphate,F-ara-AMP,磷酸氟达拉滨	Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Fludarabine Phosphate (NSC 312887 Phosphate) 是一种腺苷和脱氧腺苷类似物，与 dATP 竞争，并入到 DNA，可以抑制 DNA 聚合酶 α、核糖核苷酸还原酶和 DNA 引发酶，从而中断 DNA 合成并抑制肿瘤细胞生长。
T22337	Ganciclovir sodium RS-21592 sodium,Cytovene IV sodium,2'-Nor-2'-deoxyguanosine sodium,BW 759 sodium,更昔洛韦钠	Nucleoside Antimetabolite/Analog; Others; Antifection; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
	Ganciclovir sodium (Cytovene IV sodium) 是核苷类似物和口服抗病毒药物，具有抗病毒活性，尤其是针对巨细胞病毒和单纯疱疹病毒 1 型。
T15378	Gemcitabine elaidate Gemcitabine 5'-elaidate,反油酸吉西他滨,吉西他滨反油酸酯,Gemcitabine (elaidate),CO-101,CP-4126	Apoptosis; Nucleoside Antimetabolite/Analog; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Gemcitabine elaidate (CP-4126) 是 Gemcitabine 的亲脂性前药。它通过酯酶转化为 Gemcitabine 以被磷酸化。它具有抗肿瘤活性。

化合物

CNDAC hydrochloride

Cat.No: T13621

Target: Nucleoside Antimetabolite/Analog, Others, Drug Metabolite

3-Methylcytidine

Cat.No: T7351

Target: Nucleoside Antimetabolite/Analog

2’-OMe-Guanosine

Cat.No: T9726

Target: Apoptosis, Nucleoside Antimetabolite/Analog

6-Aminonicotinamide

Cat.No: T7545

Target: Others

6-O-Methyl Guanosine

Cat.No: T7491

Target: Nucleoside Antimetabolite/Analog

Cat.No: T15235

Target: Nucleoside Antimetabolite/Analog, HCV Protease, DNA/RNA Synthesis

DMTr-LNA-5MeU-3-CED-phosphoramidite

Cat.No: T13659

Target: Nucleoside Antimetabolite/Analog

2'-Fluoro-2'-Deoxyadenosine

Cat.No: T9727

Target: Nucleoside Antimetabolite/Analog

Cat.No: T8354

Target: Nucleoside Antimetabolite/Analog, Influenza Virus, DNA/RNA Synthesis

Cat.No: T1307

Synonym: HCFU,卡莫氟

Target: Nucleoside Antimetabolite/Analog, Virus Protease, SARS-CoV, DNA/RNA Synthesis

DMT-dG(ib) Phosphoramidite

Cat.No: T36756

Target: DNA/RNA Synthesis

Cat.No: T8648

Target: Nucleoside Antimetabolite/Analog, Influenza Virus, DNA/RNA Synthesis, Antibacterial

Cat.No: T0964

Synonym: 氟尿苷,5-Fluorouracil 2'-deoxyriboside,FUDR,Deoxyfluorouridine,NSC 27640

Target: Apoptosis, Nucleoside Antimetabolite/Analog, Others, DNA/RNA Synthesis, Antibacterial, HSV

N6,N6-Dimethyladenosine

Cat.No: T19464

Synonym: N6,N6-二甲基腺苷

Target: Nucleoside Antimetabolite/Analog

Cat.No: T40686

Synonym: NSC 286193,Riboxamide,噻唑呋林

Target: Dehydrogenase

Cat.No: T4061

Target: Nucleoside Antimetabolite/Analog, Others, Virus Protease

Cat.No: T8380

Synonym: SDX105,宾达氮芥

Target: Apoptosis, Others, DNA Alkylator/Crosslinker

Cat.No: T16911

Synonym: BV-araU,索立夫定

Target: DNA/RNA Synthesis

Tipiracil hydrochloride

Cat.No: T2366

Synonym: MA-1 hydrochloride,盐酸替吡嘧啶

Target: Nucleoside Antimetabolite/Analog

DMT-2′Fluoro-dU Phosphoramidite

Cat.No: T38958

Synonym: 2'-F-dU Phosphoramidite

Target: Nucleoside Antimetabolite/Analog

Cat.No: T0297

Synonym: Clofarex,氯法拉滨,克罗拉滨,Evoltra,Clolar

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis, Autophagy

Cat.No: T7621

Synonym: 6-Mercaptopurine riboside,6-疏基嘌呤核苷,6TI

Target: Nucleoside Antimetabolite/Analog

Cat.No: T1120

Synonym: Imidazole Carboxamide,达卡巴嗪,DTIC-Dome

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

Cat.No: T6603

Synonym: GW 506U78,Nelzarabine,奈拉滨,506U78

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

6-Mercaptopurine

Cat.No: T0010

Synonym: 6-巯基嘌呤,乐疾宁,6-MP,Mercaptopurine,6-巯基嘌呤

Target: Nucleoside Antimetabolite/Analog, Others, Dehydrogenase, Endogenous Metabolite, Autophagy

Cat.No: T1408

Synonym: Xeloda,卡培他滨,Capecitibine,Capiibine,RO 09-1978

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

Cat.No: T0251

Synonym: 吉西他滨,NSC 613327,LY188011

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis, Autophagy

Cat.No: T12399

Synonym: BCX 34

Target: Nucleoside Antimetabolite/Analog, HIV Protease

Cat.No: T1378

Synonym: Fluorafur,替加氟,FT-207,NSC 148958,FT 207

Target: Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

Cat.No: T16813

Synonym: fluorocyclopentenylcytosine,TV-1360

Target: Nucleoside Antimetabolite/Analog

N1-Methylpseudouridine

Cat.No: T19459

Synonym: N1-甲基-假尿苷,1-Methylpseudouridine

Target: Others

Cat.No: T40192

Synonym: 2′-脱氧鸟苷 5′-(四氢三磷酸酯),2'-Deoxyguanosine-5'-triphosphate

Target: Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

Cat.No: T6794

Synonym: 溴脲苷,BUdR,5-溴脱氧尿嘧啶核苷,Broxuridine,5-bromo-2'-deoxyuridine,Bromodeoxyuridine,BRDU

Target: Nucleoside Antimetabolite/Analog, Others

Cat.No: T1600

Synonym: Ro 21-9738,AMC 0101,5'-DFUR,5-Fluoro-5'-deoxyuridine,去氧氟尿苷

Target: Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

Bredinin aglycone

Cat.No: T19214

Synonym: 5-Hydroxy-1H-imidazole-4-carboxamide,5-羟基-1H-咪唑-4-甲酰胺,SM-108

Target: Others

Trifluridine/tipiracil hydrochloride mixture

Cat.No: T3658

Synonym: Trifluridine-tipiracil hydrochloride mixture,TAS102,TAS-102,TAS 102

Target: Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

Cat.No: T6632

Synonym: ZD1694,雷替曲塞,D1694,ICI-D1694,Tomudex

Target: Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

Cat.No: T1038

Synonym: NSC 118218,Fludarabinum,氟达拉宾,氟达拉滨,F-ara-A

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis, STAT

Cat.No: T0984

Synonym: 5-FU,Fluorouracil,5-氟脲嘧啶,NSC 19893,5-Fluoracil,氟尿嘧啶

Target: Apoptosis, Nucleoside Antimetabolite/Analog, HIV Protease, DNA/RNA Synthesis, Endogenous Metabolite

Cat.No: T1404

Synonym: d4T,Sanilvudine,BMY-27857,NSC 163661,司他夫定

Target: Apoptosis, Nucleoside Antimetabolite/Analog, HIV Protease, NOD-like Receptor (NLR), Reverse Transcriptase, Autophagy

Deoxycytidine triphosphate trisodium salt

Cat.No: T7518

Synonym: 2'-脱氧胞苷-5'-三磷酸三钠盐,2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE TRISODI

Target: Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis, Endogenous Metabolite, Antibiotic

Cat.No: T1428

Synonym: 曲氟尿苷,NSC 529182,Trifluorothymidine,5-Trifluorothymidine,NSC 75520,曲氟胸苷,Viroptic,Trifluridina

Target: Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis, HSV

Cat.No: T12908

Synonym: 5'-Deoxy-5'-isobutylthioadenosine,5'-Isobutylthioadenosine,5ˊ-异丁硫基-5ˊ-脱氧腺苷

Target: Nucleoside Antimetabolite/Analog, HSV

Gemcitabine hydrochloride

Cat.No: T6069

Synonym: Gemcitabine HCl,吉西他滨盐酸盐,Gemzar,LY188011,盐酸吉西他滨,LY 188011 hydrochloride

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis, Autophagy

Bendamustine hydrochloride

Cat.No: T0095

Synonym: SDX-105,SDX-105 (Cytostasane) HCl,Bendamustine HCl,EP-3101,盐酸苯达莫司汀

Target: Apoptosis, DNA Alkylator/Crosslinker, DNA/RNA Synthesis

Cat.No: T0688

Synonym: BW 759,更昔洛韦,RS-21592,2'-Nor-2'-deoxyguanosine

Target: Nucleoside Antimetabolite/Analog, Others, Antibiotic, Antifection, HSV

6-Mercaptopurine hydrate

Cat.No: T2201

Synonym: 6-Mercaptopurine monohydrate,6-巯基嘌呤(一水合物),6-Mercaptopurine (6-MP) Monohydrate,6-巯基嘌呤一水合物

Target: Nucleoside Antimetabolite/Analog, Others, DNA/RNA Synthesis

Fludarabine Phosphate

Cat.No: T6501

Synonym: NSC 312887 Phosphate,fludara Phosphate,F-ara-A (NSC 312887) Phosphate,F-ara-AMP,磷酸氟达拉滨

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

Ganciclovir sodium

Cat.No: T22337

Synonym: RS-21592 sodium,Cytovene IV sodium,2'-Nor-2'-deoxyguanosine sodium,BW 759 sodium,更昔洛韦钠

Target: Nucleoside Antimetabolite/Analog, Others, Antifection, HSV

Gemcitabine elaidate

Cat.No: T15378

Synonym: Gemcitabine 5'-elaidate,反油酸吉西他滨,吉西他滨反油酸酯,Gemcitabine (elaidate),CO-101,CP-4126

Target: Apoptosis, Nucleoside Antimetabolite/Analog, Autophagy

Cat. No.	Product Name	Target	Signaling Pathways
T5912	5-Methylcytidine	Endogenous Metabolite	Metabolism
	5-Methylcytidine 是一种位于多种体液中的嘧啶核苷。
T7319	7-Methylguanosine	Nucleoside Antimetabolite/Analog; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	7-Methylguanosine 是一种新型 cNIIIB 核苷酸酶抑制剂，IC50值为 87.8 ± 7.5 µM。
T19382	Isoguanine 2-羟基-6-氨基嘌呤,异鸟嘌呤	Nucleoside Antimetabolite/Analog	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Isoguanine 是一种嘌呤碱基，是鸟嘌呤的异构体，可作为有机合成的砌块。
T7514	N2-Methylguanosine 2-甲鳥苷	Nucleoside Antimetabolite/Analog; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	N2-Methylguanosine 是一种修饰核苷，出现在许多 tRNA 的几个特定位点。
T7520	Deoxycytidine triphosphate	Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Deoxycytidine triphosphate 是一种核苷三磷酸，是合成 DNA 的原料，可用于实时荧光定量 PCR、cDNA 合成和 DNA 测序。
T16674	Pseudouridine	Endogenous Metabolite	Metabolism
	Pseudouridine 是非编码 RNA 中丰富的修饰核苷，通过稳定 RNA 结构增强核糖体 RNA 和的转移 RNA 功能。
T2221	Uridine Uridin,β-Uridine,NSC 20256,尿苷	Others; Endogenous Metabolite	Metabolism; Others
	Uridine (Uridin) 是一种核苷化合物, 由核糖环和尿嘧啶组成, 两者通过β-N1-配糖键链接。
T0853	Adenosine 腺苷,D-Adenosine,Adenine riboside	Apoptosis; Nucleoside Antimetabolite/Analog; Endogenous Metabolite; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Adenosine (D-Adenosine) 是一种核糖核苷，由与核糖结合的腺嘌呤组成，具有血管扩张、抗心律失常和镇痛作用。
T19083	1-Methylinosine N1-Methylinosine,Inosine, 1-methyl,1-甲基肌苷	Nucleoside Antimetabolite/Analog; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	1-Methylinosine (N1-Methylinosine) 是在真核生物 tRNA 反密码子 3' 位 tRNA 的 37 位上发现的修饰核苷酸，具有代谢物的作用。
T0746	Orotic acid 乳清酸,Vitamin B13,6-Carboxyuracil	Nucleoside Antimetabolite/Analog; Dehydrogenase; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Orotic acid (Vitamin B13) 是一种嘧啶核苷酸和 RNA 生物合成的前体，从线粒体二氢乳清酸脱氢酶 (DHODH) 中释放，通过细胞质 UMP 合酶转化为 UMP。它可引起大鼠肝脂肪变性和肝肿大，是尿素循环异常的常规新生儿筛查中的一种测量指标。
T9605	Sangivamycin BA-90912,桑霉素,NSC 65346	Nucleoside Antimetabolite/Analog; PKC	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair
	Sangivamycin (NSC-65346) 是蛋白激酶 C (PKC) 的有效抑制剂 (Ki = 10 μM)。 Sangivamycin 对多种人类癌症细胞具有抗增殖活性。
T1591L	Cytidine Cytosine-1-β-D-ribofuranoside,胞苷,Cytosine β-D-riboside	Nucleoside Antimetabolite/Analog; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Cytidine (Cytosine-1-β-D-ribofuranoside) 是一种嘧啶核苷，由通过 β-N1-糖苷键与核糖结合的胞嘧啶组成。它是尿苷的前体，用于 RNA 合成。
T2218	8-Azaguanine Azaguanine-8,SK 1150,8-氮鸟嘌呤,NSC-749,SF-337	Nucleoside Antimetabolite/Analog; Others; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others
	8-Azaguanine (SK 1150) 是一种具有潜在抗肿瘤活性的嘌呤类似物。它易于掺入核糖核酸中，干扰正常的生物合成途径，从而抑制细胞生长，可作为抗代谢药。
T1508	Decitabine Dacogen,NSC 127716,地西他滨,Deoxycytidine,5-Aza-2'-deoxycytidine	Apoptosis; Nucleoside Antimetabolite/Analog; DNA Methyltransferase	Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Decitabine (Deoxycytidine) 是脱氧胞苷类似物，一种 DNA 甲基转移酶抑制剂，具有口服活性。Decitabine 具有抗肿瘤活性和抗代谢活性。Decitabine 诱导细胞周期阻滞和凋亡。
T1339	5-Azacytidine 阿托胞苷,Azacitidine,NSC 102816,Mylosar,Ladakamycin,5-氮杂胞苷,5-AzaC	Nucleoside Antimetabolite/Analog; DNA Methyltransferase; Antibacterial; Antibiotic; Autophagy	Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology
	5-Azacytidine (Ladakamycin) 是一种胞苷核苷类似物，一种 DNA 甲基化抑制剂，具有特异性。5-Azacytidine 通过降低 DNA 甲基化水平调节基因表达。5-Azacytidine 可以诱导细胞自噬，具有抗肿瘤活性。
T3271	Orotic acid zinc 乳清酸锌二水合物,Orotic acid zinc salt dihydrate,Zinc Orotate	Nucleoside Antimetabolite/Analog; Others; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others
	Orotic acid zinc (Zinc Orotate) 是一种嘧啶核苷酸和 RNA 生物合成的前体，从线粒体二氢乳清酸脱氢酶 (DHODH) 中释放，通过细胞质 UMP 合酶转化为 UMP。它可引起大鼠肝脂肪变性和肝肿大，是尿素循环异常的常规新生儿筛查中的一种测量指标。
T1272	Cytarabine 阿糖胞苷,Ara-C,Cytosine Arabinoside,Cytosine β-D-arabinofuranoside,Arabinocytidine	Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; Endogenous Metabolite; Autophagy; HSV	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
	Cytarabine (Ara-C) 是一种核苷类似物，一种 DNA 合成抑制剂 (IC50=16 nM)。Cytarabine 可以抑制 DNA 聚合酶，诱导细胞周期阻滞、细胞自噬和凋亡。Cytarabine 具有抗肿瘤活性。
T1506	Vidarabine Adenine Arabinoside,阿糖腺苷,9-β-D-Arabinofuranosyladenine,Vira-A,Arabinosyladenine,Ara-A	Nucleoside Antimetabolite/Analog; Tyrosine Kinases; DNA/RNA Synthesis; Antibiotic; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Tyrosine Kinase/Adaptors
	Vidarabine (Adenine Arabinoside) 是从链霉菌分离的核苷类抗生素，能抗单纯性疱疹和水痘-带状疱疹病毒。它对 HSV-1 和 HSV-2 的 IC50值分别为 9.3 μg/ml 和 11.3 μg/ml。
T9086	Deoxythymidine-5'-triphosphate trisodium dTTP trisodium salt,thymidine 5'-(trisodium hydrogen triphosphate),胸苷-5'-三磷酸三钠盐,脱氧胸苷三磷酸三钠盐,Deoxythymidine-5'-triphosphate (dTTP) trisodium salt	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Deoxythymidine-5'-triphosphate trisodium (Deoxythymidine-5'-triphosphate(dTTP) trisodium salt) 是四种天然脱氧核苷酸之一，用于通过 DNA 聚合酶和逆转录酶生物合成脱氧核糖核酸。
T2993	Cordycepin 3'-Deoxyadenosine,虫草素	MMP; TNF; Antibacterial; Antibiotic; Autophagy	Apoptosis; Autophagy; Microbiology/Virology; Proteases/Proteasome
	Cordycepin (3'-Deoxyadenosine) 是一种核苷衍生物，在类风湿性关节炎滑膜成纤维细胞中，剂量依赖性抑制 IL-1β 诱导的 MMP-1和 MMP-3表达。它也抑制细菌的腺苷激酶从而抗结核分枝杆菌。
T1721	2'-Deoxyuridine Uracil deoxyriboside,2-deoxyuridine,2'-dU,2'-脱氧尿苷	Others; DNA/RNA Synthesis; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others
	2'-Deoxyuridine (2-deoxyuridine) 可以促使染色体断裂，从而抑制 thymidylate 的合成活性，它也是合成 Edoxudine 的前体。

天然产物

5-Methylcytidine

Cat.No: T5912

Target: Endogenous Metabolite

7-Methylguanosine

Cat.No: T7319

Target: Nucleoside Antimetabolite/Analog, Endogenous Metabolite

Cat.No: T19382

Synonym: 2-羟基-6-氨基嘌呤,异鸟嘌呤

Target: Nucleoside Antimetabolite/Analog

N2-Methylguanosine

Cat.No: T7514

Synonym: 2-甲鳥苷

Target: Nucleoside Antimetabolite/Analog, Endogenous Metabolite

Deoxycytidine triphosphate

Cat.No: T7520

Target: Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis, Endogenous Metabolite

Cat.No: T16674

Target: Endogenous Metabolite

Cat.No: T2221

Synonym: Uridin,β-Uridine,NSC 20256,尿苷

Target: Others, Endogenous Metabolite

Cat.No: T0853

Synonym: 腺苷,D-Adenosine,Adenine riboside

Target: Apoptosis, Nucleoside Antimetabolite/Analog, Endogenous Metabolite, Autophagy

1-Methylinosine

Cat.No: T19083

Synonym: N1-Methylinosine,Inosine, 1-methyl,1-甲基肌苷

Target: Nucleoside Antimetabolite/Analog, Endogenous Metabolite

Cat.No: T0746

Synonym: 乳清酸,Vitamin B13,6-Carboxyuracil

Target: Nucleoside Antimetabolite/Analog, Dehydrogenase, Endogenous Metabolite

Cat.No: T9605

Synonym: BA-90912,桑霉素,NSC 65346

Target: Nucleoside Antimetabolite/Analog, PKC

Cat.No: T1591L

Synonym: Cytosine-1-β-D-ribofuranoside,胞苷,Cytosine β-D-riboside

Target: Nucleoside Antimetabolite/Analog, Endogenous Metabolite

Cat.No: T2218

Synonym: Azaguanine-8,SK 1150,8-氮鸟嘌呤,NSC-749,SF-337

Target: Nucleoside Antimetabolite/Analog, Others, Endogenous Metabolite

Cat.No: T1508

Synonym: Dacogen,NSC 127716,地西他滨,Deoxycytidine,5-Aza-2'-deoxycytidine

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA Methyltransferase

Cat.No: T1339

Synonym: 阿托胞苷,Azacitidine,NSC 102816,Mylosar,Ladakamycin,5-氮杂胞苷,5-AzaC

Target: Nucleoside Antimetabolite/Analog, DNA Methyltransferase, Antibacterial, Antibiotic, Autophagy

Orotic acid zinc

Cat.No: T3271

Synonym: 乳清酸锌二水合物,Orotic acid zinc salt dihydrate,Zinc Orotate

Target: Nucleoside Antimetabolite/Analog, Others, Endogenous Metabolite

Cat.No: T1272

Synonym: 阿糖胞苷,Ara-C,Cytosine Arabinoside,Cytosine β-D-arabinofuranoside,Arabinocytidine

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis, Endogenous Metabolite, Autophagy, HSV

Cat.No: T1506

Synonym: Adenine Arabinoside,阿糖腺苷,9-β-D-Arabinofuranosyladenine,Vira-A,Arabinosyladenine,Ara-A

Target: Nucleoside Antimetabolite/Analog, Tyrosine Kinases, DNA/RNA Synthesis, Antibiotic, HSV

Deoxythymidine-5'-triphosphate trisodium

Cat.No: T9086

Synonym: dTTP trisodium salt,thymidine 5'-(trisodium hydrogen triphosphate),胸苷-5'-三磷酸三钠盐,脱氧胸苷三磷酸三钠盐,Deoxythymidine-5'-triphosphate (dTTP) trisodium salt

Target: DNA/RNA Synthesis

Cat.No: T2993

Synonym: 3'-Deoxyadenosine,虫草素

Target: MMP, TNF, Antibacterial, Antibiotic, Autophagy

2'-Deoxyuridine

Cat.No: T1721

Synonym: Uracil deoxyriboside,2-deoxyuridine,2'-dU,2'-脱氧尿苷

Target: Others, DNA/RNA Synthesis, Endogenous Metabolite

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