Powder: -20°C for 3 years | In solvent: -80°C for 1 year
6-Mercaptopurine hydrate (6-Mercaptopurine monohydrate) 是一种核苷代谢抑制剂。它通过抑制嘌呤代谢来干扰核酸合成,通常与其他药物联合用于白血病的治疗或缓解维持计划。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 mg | ¥ 155 | 现货 | ||
25 mg | ¥ 229 | 现货 | ||
50 mg | ¥ 319 | 现货 | ||
100 mg | ¥ 458 | 现货 | ||
200 mg | ¥ 645 | 现货 | ||
500 mg | ¥ 822 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 185 | 现货 |
产品描述 | 6-Mercaptopurine hydrate (6-Mercaptopurine monohydrate) is a Nucleoside Metabolic Inhibitor. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. |
体外活性 | Mercaptopurine is widely used to treat malignancies, rheumatic diseases, dermatologic conditions, inflammatory bowel disease, and solid organ transplant rejection. [1] Mercaptopurine inhibits purine nucleotide synthesis and metabolism by inhibiting an enzyme called Phosphoribosyl pyrophosphate amidotransferase (PRPP Amidotransferase). PRPP Amidotransferase is the rate limiting enzyme of purine synthesis. It alters the synthesis and function of RNA and DNA. Mercaptopurine interferes with nucleotide interconversion and glycoprotein synthesis. [2] |
别名 | 6-Mercaptopurine monohydrate, 6-巯基嘌呤(一水合物), 6-Mercaptopurine (6-MP) Monohydrate, 6-巯基嘌呤 一水合物 |
分子量 | 170.19 |
分子式 | C5H6N4OS |
CAS No. | 6112-76-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 100 mg/mL
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
6-Mercaptopurine hydrate 6112-76-1 Cell Cycle/Checkpoint DNA Damage/DNA Repair Others DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Mercaptopurine 6-Mercaptopurine Monohydrate 6Mercaptopurine hydrate Inhibitor 6-MP 6-Mercaptopurine monohydrate 6-Mercaptopurine 6-巯基嘌呤(一水合物) 6 Mercaptopurine hydrate 6-Mercaptopurine (6-MP) Monohydrate inhibit 6-Mercaptopurine (6-MP) 6-巯基嘌呤 一水合物 6-Mercaptopurine Hydrate inhibitor