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Search Results for " anti-metastasis "

16

抑制剂 & 化合物

10

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8310	MMP-9-IN-1	MMP	Proteases/Proteasome
	MMP-9-IN-1 是特异性的基质金属蛋白酶-9 抑制剂，选择性靶向 MMP-9 的血红素域，对其他 MMP 无影响。
T4306	CCG-203971 CCG203971	Rho; Ras	Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	CCG-203971 是一种Rho/MRTF/SRF 通路抑制剂，具有潜在的抗转移作用。它有效靶向 RhoA/C 激活的 SRE 荧光素酶，IC50为 6.4 μM。它抑制 PC-3 细胞迁移，IC50为 4.2 μM。
T77059	Leronlimab PRO 140	CCR	Immunology/Inflammation; Microbiology/Virology
	Leronlimab (PRO 140) 是一种人源化 IgG4 抗 CCR5 单克隆抗体。leronlimumab 具有抗 HIV 病毒活性和抗肿瘤活性，抑制 CCR 介导的 HIV-1 病毒和小鼠肿瘤模型中癌细胞转移。Leronlimab 可用于研究 HIV 非酒精性脂肪性肝炎 (NASH) 和乳腺癌。
T77743	TT-012	Others	Others
	TT-012 具有抗肿瘤活性，选择性结合动态 MITF，并破坏后者的二聚体形成和 DNA 结合。TT-012 对 B16F10 黑色素瘤细胞中 MITF 的转录有抑制作用。TT-012 在动物模型中对 MITF黑色素瘤细胞的生长和肿瘤生长转移有抑制作用。TT-012 对肝脏和免疫细胞具有较少的细胞毒性。
T11325	Frondoside A	Others	Others
	possesses anticancer, anti-invasive, anti-metastasis, anti-angiogenic and pro-apoptosis properties with high safety.Frondoside A, a natural glycoside extracted from the sea cucumber, Cucumaria frondosa,
T12650	R916562	TAM Receptor	Tyrosine Kinase/Adaptors
	R916562 is an orally active and selective Axl/VEGF-R2 inhibitor with IC50s of 136 nM and 24 nM, respectively. R916562 has anti-angiogenesis and anti-metastasis.
T10273	AhR modulator-1	Others	Others
	AhR modulator-1 is a selective and orally active aryl hydrocarbon receptor (AhR) modulator. It inhibits metastasis, in part, by inhibiting prostatic VEGF production prior to tumor formation. It also possesses anti-estrogenic properties in rat uterus.
T79410	anti-TNBC agent-3
	Anti-TNBC agent-3 (compound 3g) 作为凋亡诱导剂，展现了抗增殖活性针对癌细胞。在三阴性乳腺癌(TNBC)异种移植模型上，该化合物有效地抑制了肿瘤生长及其转移。
T62119	Lasofoxifene
	Lasofoxifene (CP-336156) 是一种选择性的、口服具有活力的雌激素受体调节剂 (SERM)。Lasofoxifene 对原生肿瘤的生长和转移具有抑制作用，也能够抗骨质疏松。Lasofoxifene 能够用于研究乳腺癌和绝经后骨质疏松症。
T70344	BJ-2302
	BJ-2302 is a SRC inhibitor. BJ-2302 effectively suppressed MDA-MB-231 cell invasion (Matrigel invasion assay) and metastasis (chorioallantoic membrane assay xenografted with MDA-MB-231-luc2-tdTomato cancer cells). Additionally, BJ-2302 (1 mg/kg) strongly suppressed TNBC cell proliferation in vitro and tumor growth in a xenograft mouse tumor model. The anti-metastatic and anti-tumor effects of BJ-2302 were superior to those of Z-FL-COCHO (1 mg/kg) or batimastat (30 mg/kg), a pan-MMP inhibitor.
T79699	anti-TNBC agent-2	Apoptosis	Apoptosis
	Anti-TNBC agent-2（3j）是一款针对三阴性乳腺癌（TNBC）的嘌呤衍生化合物。它能够引导MDA-MB-231细胞走向凋亡（apoptosis），阻碍其迁移和血管生成能力，并在TNBC异种移植模型中，抑制肿瘤生长与转移，同时下调Ki67和CD31蛋白的表达水平。Anti-TNBC agent-2主要用于三阴性乳腺癌的科研领域。
T74859	SLC7A11-IN-1
	SLC7A11-IN-1 是一种有效的 SLC7A11抑制剂。SLC7A11-IN-1 显示出抗增殖活性。SLC7A11-IN-1 抑制细胞侵袭和转移。SLC7A11-IN-1 诱导细胞凋亡 (Apoptosis) 和细胞周期停滞在 S 期。SLC7A11-IN-1 具有抗肿瘤活性。
T63648	EGFR kinase inhibitor 1
	EGFR kinase inhibitor 1 是 EGFR 的有效抑制剂，能够作用于 WT (IC50: 37 nM)，l885R/T790M (IC50: 1.7 nM)，L858R/T790M/C797S (IC50>300 nM)。EGFR kinase inhibitor 1 能够将细胞周期阻滞在 G0/G1 期，诱导细胞凋亡 (apoptosis)，对细胞转移显示出抑制作用。EGFR kinase inhibitor 1 表现出抗增殖和抗肿瘤效果。
T74393	Antitumor agent-36
	Antitumor agent-36 具有有效的抗增殖和抗转移活性，能诱导严重的 DNA 损伤，并通过增加 γ-H2AX 和 p53 的表达促进肿瘤细胞通过 Bcl-2/Bax/caspase3 线粒体凋亡通路的 (apoptosis)。此外，Antitumor agent-36 还能通过抑制 PD-L1 的表达显著增加肿瘤组织中 CD3+ 和 CD8+ T 浸润细胞，从而改善免疫反应。
T79647	VEGFR/PARP-IN-1	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	VEGFR/PARP-IN-1 (Compound 14b) 是一款针对VEGFR和PARP两个靶点的双重抑制剂，其对VEGFR和PARP的IC50值分别为191 nM和60.9 nM。该化合物能够抑制DNA损伤修复机制，诱导apoptosis，并使细胞在G2/M期阻滞。此外，VEGFR/PARP-IN-1对BRCA野生型乳腺癌细胞表现出较强的抗增殖效果，尤其是在MDA-MB-231和MCF-7细胞系上，其IC50值分别为4.1 μM和3.5 μM，是潜在的抗肿瘤和抗转移药物。
T35993	Epitalon (acetate)
	Epitalon is a synthetic tetrapeptide with anti-aging properties.1,2,3,4 Dietary administration of epitalon (0.00001% w/w) reduces levels of lipid peroxidation products in aged D. melanogaster tissue homogenates.1 Epitalon (1 μg/animal) delays age-related estrous shutdown and decreases the frequency of bone marrow cell chromosomal aberrations in female mice.2 It decreases spontaneous mammary gland and ovarian tumor development and metastasis in aged female mice.3 Epitalon also stimulates melatoni...

化合物

Cat.No: T8310

Target: MMP

Cat.No: T4306

Synonym: CCG203971

Target: Rho, Ras

Cat.No: T77059

Synonym: PRO 140

Target: CCR

Cat.No: T77743

Target: Others

Cat.No: T11325

Target: Others

Cat.No: T12650

Target: TAM Receptor

AhR modulator-1

Cat.No: T10273

Target: Others

anti-TNBC agent-3

Cat.No: T79410

Cat.No: T62119

Cat.No: T70344

anti-TNBC agent-2

Cat.No: T79699

Target: Apoptosis

Cat.No: T74859

EGFR kinase inhibitor 1

Cat.No: T63648

Antitumor agent-36

Cat.No: T74393

VEGFR/PARP-IN-1

Cat.No: T79647

Target: PARP

Epitalon (acetate)

Cat.No: T35993

Cat. No.	Product Name	Target	Signaling Pathways
T2982	Xanthone Genicide,呫吨酮,氧杂蒽酮,Xanthenone,Benzophenone oxide	Apoptosis; Others; Influenza Virus; Antibacterial; Antifungal	Apoptosis; Microbiology/Virology; Others
	Xanthone (Xanthenone) 是一种从山竹果中分离得到的天然产物，具有抗炎，抗氧化，抗肿瘤，抗过敏，抗细菌，抗真菌和抗病毒活性。在癌变的不同阶段可控制细胞分裂和生长，凋亡，炎症和转移。
T2786	Oxysophocarpine 氧化槐树碱,氧卡地平	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Oxysophocarpine 是提取自海藻的生物碱。它抑制口腔鳞状细胞癌的生长和转移。它对中枢神经系统和周围神经系统具有神经保护作用和抗伤害感受作用。
T8169	Decursinol	Others	Others
	Decursinol 是一种分离自Angelica gigas 的根中的、口服具有活性的抗伤害药物。它具有抗肿瘤和抗转移作用。
T4S1383	Escin IA Aescin IA,Escin IA;Aescin IA,Escin IA	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Escin IA (Escin IA;Aescin IA);Aescin IA 是从马蹄中七叶树分离出的一种三萜皂苷，抑制HIV-1蛋白酶，IC50值为 35 μM。它具有抗 TNBC 转移活性，其作用机制涉及通过下调 LOXL2 表达抑制上皮-间质转化过程。
T3402	20(S)-Ginsenoside Rg3 20(S)-人参皂苷 Rg3,人参皂苷 Rg3,20(S)-Ginsenoside-Rg3,Rg3,20S-Ginsenoside Rg3,Ginsenoside Rg3,S-Ginsenoside Rg3	EGFR; Beta Amyloid; Potassium Channel; NF-κB; COX; Sodium Channel; Endogenous Metabolite	Angiogenesis; Immunology/Inflammation; JAK/STAT signaling; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB; Tyrosine Kinase/Adaptors
	20(S)-Ginsenoside Rg3 (Rg3) 是红参的主要成分，通过抑制肿瘤细胞的粘附和侵袭来抑制肿瘤细胞肺转移。它抑制Na+和hKv1.4通道，IC50分别为 32.2±4.5 和 32.6±2.2 μM。它还抑制Aβ，NF-κB 活性和COX-2表达，抑制人脐静脉内皮细胞的增殖并具有抗血管生成活性。
T3403	Glabridin 光甘草定,Q-100692,KB-289522,LS-176045	Reactive Oxygen Species; Tyrosinase; GABA Receptor; Antibacterial; PPAR	DNA Damage/DNA Repair; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome
	Glabridin (KB-289522) 能够结合并激活PPARγ，EC50值为 6115 nM，是一种从Glycyrrhiza glabra 中分到的异黄烷类天然产物。它具有抗炎、抗菌、抗肾炎、抗氧化、抗肿瘤、抗糖尿病、抗骨质疏松、保护神经、保护心血管、清除自由基等作用。
T6S1699	Shogaol [6]-Shogaol,姜烯酚,6-姜烯酚,6-Shogaol	Lipoxygenase; Autophagy	Autophagy; Metabolism
	6-Shogaol (6-Shogaol) 是从生姜中分离的一种天然产物，具有抗癌、抗炎和抗氧化的多种生物活性。
T4S0969	Obtusifolin 决明蒽醌,决明蒽醌；美决明子素	Antioxidant; NF-κB	NF-κB; oxidation-reduction
	Obtusifolin 是分离自决明子的种子中，能够抑制NF-kB 通路，调节气道上皮细胞中 MUC5AC 粘蛋白的基因表达和产生。它通过靶向甲状旁腺激素相关蛋白来抑制邻苯二甲酸酯诱导的乳腺癌骨转移。
TN5901	Cudratricusxanthone A
	Cudratricusxanthone A has potent anti-proliferative, antioxidative, and monoamine oxidase inhibitory effects, it also possesses anti-cancer activities and provide a basis for developing effective therapeutic agents to inhibit growth and metastasis of brea
TN3587	Capillarisin	MMP; ERK; IL Receptor; BCL; VEGFR; TNF; NOS; NF-κB; TLR; MAPK; COX; DNA/RNA Synthesis; Prostaglandin Receptor; JNK; STAT	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; MAPK; Neuroscience; NF-κB; Proteases/Proteasome; Stem Cells; Tyrosine Kinase/Adaptors
	Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cells, it inhibits cancer cell growth of osteosarcoma cells by inducing apoptosis accompanied with

天然产物

Cat.No: T2982

Synonym: Genicide,呫吨酮,氧杂蒽酮,Xanthenone,Benzophenone oxide

Target: Apoptosis, Others, Influenza Virus, Antibacterial, Antifungal

Oxysophocarpine

Cat.No: T2786

Synonym: 氧化槐树碱,氧卡地平

Target: Prostaglandin Receptor

Cat.No: T8169

Target: Others

Cat.No: T4S1383

Synonym: Aescin IA,Escin IA;Aescin IA,Escin IA

Target: HIV Protease

20(S)-Ginsenoside Rg3

Cat.No: T3402

Synonym: 20(S)-人参皂苷 Rg3,人参皂苷 Rg3,20(S)-Ginsenoside-Rg3,Rg3,20S-Ginsenoside Rg3,Ginsenoside Rg3,S-Ginsenoside Rg3

Target: EGFR, Beta Amyloid, Potassium Channel, NF-κB, COX, Sodium Channel, Endogenous Metabolite

Cat.No: T3403

Synonym: 光甘草定,Q-100692,KB-289522,LS-176045

Target: Reactive Oxygen Species, Tyrosinase, GABA Receptor, Antibacterial, PPAR

Cat.No: T6S1699

Synonym: [6]-Shogaol,姜烯酚,6-姜烯酚,6-Shogaol

Target: Lipoxygenase, Autophagy

Cat.No: T4S0969

Synonym: 决明蒽醌,决明蒽醌；美决明子素

Target: Antioxidant, NF-κB

Cudratricusxanthone A

Cat.No: TN5901

Cat.No: TN3587

Target: MMP, ERK, IL Receptor, BCL, VEGFR, TNF, NOS, NF-κB, TLR, MAPK, COX, DNA/RNA Synthesis, Prostaglandin Receptor, JNK, STAT

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