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Search Results for " s-10 "

Targets Recommended: Topoisomerase

136

抑制剂 & 化合物

16

天然产物

15

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T60123	Chimmitecan (S)-9-Allyl-10-hydroxycamptothecin,吉米替康	Topoisomerase	DNA Damage/DNA Repair
	Chimmitecan ((S)-9-Allyl-10-hydroxycamptothecin) 是一种topoisomerase I 抑制剂，在体内、外表现有效的活性。
T37863	9(S),10(S),13(S)-TriHOME
	9(S),10(S),13(S)-TriHOME is an oxylipin derived from linoleic acid. It has been detected in beer and in bronchoalveolar lavage fluid (BALF) from female smokers.
T35447	10(S)-PAHSA
	10(S)-PAHSA is a stereoisomer of 10-PAHSA , an endogenous lipid that belongs to a collection of branched fatty acid esters of hydroxy fatty acids (FAHFAs).
T37488	10(S),17(S)-DiHDHA
	Protectin D1 (also known as neuroprotectin D1 when produced in neuronal tissues) is a DHA-derived dihydroxy fatty acid that exhibits potent protective and anti-inflammatory activities. 10(S),17(S)-DiHDHA is a DHA metabolite, also referred to as protectin DX (PDX). It is produced by an apparent double lipoxygenase (LO)-mediated reaction in murine peritonitis exudates, in suspensions of human leukocytes, or by soybean 15-LO incubated with DHA. It differs from protectin D1 with respect to the stere...
T18669L	(S,R,S)-AHPC-Me-C10-NH2 hydrochloride (S,R,S)-AHPC-Me-C10-NH2盐酸盐	Ligand for E3 Ligase	PROTAC
	(S,R,S)-AHPC-Me-C10-NH2 hydrochloride 是一种合成的 E3 连接酶配体-接头偶联物，包含 VHL 配体和接头。
T17881	(S,R,S)-AHPC-C10-NH2 VH032-C10-NH2	Others; Ligand for E3 Ligase	Others; PROTAC
	(S,R,S)-AHPC-C10-NH2 (VH032-C10-NH2) 包含基于 (S,R,S)-AHPC 的VHL 配体和 1 个 linker，是一种合成的 E3 连接酶配体-linker 偶联物 (E3 ligase ligand-linker conjugate)。用于 BET 的靶向 PROTAC 的合成。
T36999	7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
	Novel oxylipins, referred to as docosanoids, have been derived from C22polyunsaturated fatty acids 7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic acid (7(S),17(S)-hydroxy DPA) is a DPA-derived analog of the 17(S)-dihydroxy series of docosanoids known as protectins. Protectin D1, a DHA-derived dihydroxy fatty acid, exhibits potent anti-inflammatory activities.1,2,3Potentially, 7(S),17(S)-hydroxy DPA demonstrates similar properties; however, its biological activity has yet to b...
T32781	Lipofundin S Phospholipid - stabilized soybean oil,Intralipid,Intralipid 20,Medialipid,Lipofundin S 10
	Lipofundin S is an emulsion containing soybean oil, glycerol, and soy phosphatides.
T34106	Polyglyceryl-10 stearate Polyaldo 10-1-S,Decaglyceryl monostearate,Nikkol decaglyn 1-SV EX,Nikkol decaglyn 1-SV,Nikkol decaglyn 1-S
	Polyglyceryl-10 stearate is a biochemical.
T18669	(S,R,S)-AHPC-Me-C10-NH2	Others	Others
	(S,R,S)-AHPC-Me-C10-NH2 is a chemical compound consisting of a synthesized E3 ligase ligand-linker conjugate that incorporates both a VHL ligand and a linker. This compound, (S,R,S)-AHPC-Me-C10-NH2, finds application in PROTAC MS432[1].
T18661	(S,R,S)-AHPC-C10-NH2 dihydrochloride VH032-C10-NH2 dihydrochloride,VH032-linker 10,(S,R,S)-AHPC-C10-NH2二盐酸盐,VH032 amide-alkylC10-amine	Others; Ligand for E3 Ligase	Others; PROTAC
	(S,R,S)-AHPC-C10-NH2 dihydrochloride (VH032-linker 10) 包含基于 (S,R,S)-AHPC 的VHL 配体和 1 个 linker，是一种合成的 E3 连接酶配体-linker 偶联物，用于合成 BET 的靶向 PROTAC。
T18668	(S,R,S)-AHPC-Me-C10-Br	Others	Others
	(S,R,S)-AHPC-Me-C10-Br is a chemically synthesized conjugate that functions as a ligand-linker for E3 ligases. This compound incorporates a VHL E3 ligase linker and MS432, derived from the MEK1/2 inhibitor PD0325901[1].
T17910	(S,R,S)-AHPC-PEG2-C4-Cl E3 ligase Ligand-Linker Conjugates 10,VHL Ligand-Linker Conjugates 7,VH032-PEG2-C4-Cl	Others	Others
	(S,R,S)-AHPC-PEG2-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-PEG2-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].
T17926	(S,R,S)-AHPC-PEG6-C4-Cl VHL Ligand-Linker Conjugates 10,E3 ligase Ligand-Linker Conjugates 9,VH032-PEG6-C4-Cl	Others	Others
	(S,R,S)-AHPC-PEG6-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 6-unit PEG linker. (S,R,S)-AHPC-PEG6-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].
T2303	(S)-Afatinib BIBW2992,阿法替尼	EGFR; HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	(S)-Afatinib (BIBW2992) 是一种不可逆的 EGFR 家族抑制剂，对 EGFRwt、EGFR (L858R)、EGFR (L858R/T790M)、HER2 和 HER4 的 IC50 分别为 0.5/0.4/10/14/1 nM。
T2012	Oclacitinib PF-03394197	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	Oclacitinib (PF-03394197) 是一种有效的选择性 JAKs 抑制剂，IC50 为 10-99 nM；不抑制一组 38 种非 JAK 激酶 (IC50 > 1000 nM)。
T20828	Citalopram Cipram,Lu 10-171,Lu-10-171 Lu10-171	5-HT Receptor	GPCR/G Protein; Neuroscience
	Citalopram (Lu 10-171) 是一种具有口服活性的、选择性的血清素再摄取抑制剂 (SSRI)，是一种选择性5-羟色胺再摄取抑制剂，是一种 S(+)-对映体 (Escitalopram) 和 R(-)-对映体的外消旋混合物。Citalopram 具有抗抑郁活性，可增强血清素能神经传递，可用于研究老年痴呆。
T19649	PF-06273340 PF 6273340,PF 06273340,PF6273340,PF-6273340	Trk receptor	Tyrosine Kinase/Adaptors
	PF-06273340 是一种口服具有活力的、具有选择性的外周限制性Trk 泛抑制剂。
T1850	Balicatib AAE581,巴利卡替	Cysteine Protease	Proteases/Proteasome
	Balicatib (AAE581) 是组织蛋白酶K 抑制剂，其对组织蛋白酶K 的抑制作用是组织蛋白酶B、L 和S 的抑制性的10到100倍。
T2368L	Edoxaban Lixiana,依杜沙班	Factor Xa; Thrombin	Metabolism; Proteases/Proteasome
	Edoxaban (Lixiana) (DU-176) 是一种选择性的，口服有效的 factor Xa (FXa)抑制剂。Edoxaban 对游离 FXa 和凝血酶原的 Ki 分别为 0.561 nM 和 2.98 nM。Edoxaban 是一种抗凝剂，可用于预防中风。Edoxaban 还是一种凝血酶和凝血因子 IXaβ (FIXa) 的弱抑制剂，Ki 值分别为 6.00 μM 和 41.7 μM，对 FXa 的选择性超过 10000 倍。由于具有抗血栓形成的特性，Edoxaban 可用于预防血栓栓塞性疾病的研究。
T0153	Oltipraz 吡噻硫酮,NSC 347901,RP 35972	HIF/HIF Prolyl-Hydroxylase; HIV Protease; Reverse Transcriptase; Nrf2; HIF	Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; Microbiology/Virology; Proteases/Proteasome
	Oltipraz (RP 35972) 是一种 Nrf2的强效激活剂。它时间依赖性地抑制 HIF-1α激活，IC50为 10 μM，浓度 ≥ 10 μM 时完全消除 HIF-1α诱导。
T62694	(S)-GFB-12811
	(S)-GFB-12811 (compound 596) 是一种选择性的、选择性的 CDK5 抑制剂 (IC50<10 nM)。(S)-GFB-12811 能够用于细胞周期进程、神经元发育、肿瘤发生的研究。
T37721	Dihydronovobiocin
	Dihydronovobiocin is a coumarin antibiotic and derivative of novobiocin .1It is active against the bacteriaS. aureus,S. haemolyticus,D. pneumoniae,S. typhosa,K. pneumoniae, andP. multocida(MICs = 0.6, 2, 0.6, 10, 10, and 3 μg/ml, respectively).2Dihydronovobiocin inhibits DNA gyrase subunit B with an IC50value of 64.5 nM.3 1.Berger, J., and Batcho, A.D.Coumarin - glycoside antibioticsJ. Chromatogr. Lib.15101-158(1978) 2.Hoeksema, H.Dihydronovobiocin and derivatives thereof3,175,9441-9(1965) 3.Gev...
T28391	PF-9404C PF9404C
	PF-9404C is the S-S diesteroisomer of a beta adrenergic receptors blocker with vasodilatory properties. PF9404C increased the formation of cyclic GMP from 3 pmol mg−1 protein in basal conditions, to 53 pmol mg−1 protein in 10 μM in rat aorta smooth muscle
T29007	Trichostatin A S-isomer (-)-Trichostatin A
	Trichostatin A S-isomer is the s-isomer of Trichostatin A. Trichostatin A is a histone deacetylase inhibitors (HDIs or HDACIs) that have a broad spectrum of epigenetic activities. Trichostatin A inhibits HDACs 1, 3, 4, 6 and 10 with IC50 values around 20
T83699	LL-37 (18-37) (human) TFA KR-20,hCAP-18,CAP-18,Cathelicidin,FALL-39
	LL-37 (18-37) 是 LL-37 的一种抗菌肽片段。对S. aureus和C. albicans具有活性，最小致死浓度分别为4 µM 和10 µM。在10到50 µM 的浓度范围内，它还能抑制E. histolytica营养体的生长。
T71449	Capreomycin free base
	Capreomycin is a polypeptide antibiotic originally isolated from S. capreolus. It is active against M. tuberculosis (MIC = 10 µg/ml). Capreomycin binds to both the 30S and 50S ribosomal subunits, inhibiting protein synthesis.
T35607	10'-Desmethoxystreptonigrin
	10'-Desmethoxystreptonigrin is an antibiotic originally isolated from Streptomyces and a derivative of the antibiotic streptonigrin. It is active against a variety of bacteria, including S. aureus, S. faecalis, E. coli, K. pneumoniae, and P. vulgaris (MICs = 0.4, 1.6, 3.1, 3.1 and 0.4 μg/ml, respectively). 10'-Desmethoxystreptonigrin is cytotoxic to HCT116 colon and A2780 ovarian cancer cells (IC50s = 0.004 and 0.001 μg/ml, respectively), as well as HCT116 cells resistant to etoposide and tenipo...
T36769	10-hydroxy Warfarin
	10-hydroxy Warfarin is a metabolite of (R)-warfarin .1It is formed from (R)-warfarin by the cytochrome P450 (CYP) isoform CYP3A4. 10-hydroxy Warfarin is an inhibitor of CYP2C9 (IC50= 1.6 μM), the enzyme that converts (S)-warfarin to its 6-hydroxy warfarin and 7-hydroxy warfarin metabolites.2 1.Kaminsky, L.S., and Zhang, Z.-Y.Human P450 metabolism of warfarinPharmacol. Ther.73(1)67-74(1997) 2.Jones, D.R., Kim, S.-Y., Guderyon, M., et al.Hydroxywarfarin metabolites potently inhibit CYP2C9 metaboli...
T80407	Peptide 5g
	Peptide 5g 是一种具有广谱抗菌特性的化合物。它对 E. coli, S. aureus 和 C. albicans 的最小抑制浓度 (MIC) 值显著，分别为 30 μg/mL、10 μg/mL 和 12.5 μg/mL。
T65737	(S)-3-(1-(Dimethylamino)ethyl)phenol
	(S)-3-(1-(Dimethylamino)ethyl)phenol 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65737，CAS号为 139306-10-8。
T77920	ZXH-4-130 TFA	PROTACs	PROTAC
	ZXH-4-130 TFA为高效、选择性CRBN降解剂，属于CRBN-VHL类(hetero-PROTAC)化合物。在MM1.S细胞中，10 nM ZXH-4-130 TFA可诱导约80%的CRBN降解。
T78765	SARS-CoV-2-IN-51	SARS-CoV	Microbiology/Virology
	SARS-CoV-2-IN-51（S-10）为针对Omicron的融合抑制剂有效先导化合物，具有抑制Omicron及其他变体的能力，EC50值介于0.82-5.45 μM之间。该化合物通过与SARS-CoV-2病毒S蛋白预融合状态下直接相互作用，从而抑制病毒进入。
T37157	8(S)-HEPE
	8(S)-HEPE is a monohydroxy fatty acid produced by lipoxygenase oxidation of EPA. It acts to promote hatching of barnacle eggs at 10 nM, although it is not clearly identified as the natural egg hatching factor.
T67218	(S)-N,N-Dimethyl-1,2,4,5,6,7-hexahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-12-amine
	(S)-N,N-Dimethyl-1,2,4,5,6,7-hexahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-12-amine 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T67218，CAS号为 443965-10-4。
T38289	Leucomycin A13 Leucomycin A13
	Leucomycin A13 is a macrolide antibiotic and a component of the leucomycin complex originally isolated from S. kitasatoensis. It is active against B. subtilis, S. aureus, M. luteus, and E. coli with MIC values of 0.16, 0.16, 0.08 and >10 μg/ml, respectively. It binds to ribosomes with an IC50 value of 1.2 μM in a radioligand binding assay.
T11138	(E)-LHF-535	Others	Others
	(E)-LHF-535 是 LHF-535 的E 异构体， LHF-535 是一种抗病毒剂，对 Lassa，Machupo，Junin，VSVg 病毒的 EC50分别为 <1 μM，<1 μM，<1 μM 和 1-10 μM。
T70642	Lanopepden camsylate
	Lanopepden, also known as GSK-1322322 or GSK-322, is a potent and selective peptide deformylase inhibitor with good in vitro activity against bacteria associated with community-acquired pneumonia and skin infections. GSK1322322 had bactericidal activity against S. pneumoniae, H. influenzae, S. pyogenes, and S. aureus, demonstrating a ≥ 3-log(10) decrease in the number of CFU/ml at 4× MIC within 24 h in 29 of the 33 strains tested. GSK1322322 represents a valuable alternative therapy for the trea...
T37166	RCTR1
	Resolvin conjugate in tissue regeneration 1 (RCTR1) is a specialized pro-resolving mediator (SPM) biosynthesized from docosahexaenoic acid by isolated human macrophages and apoptotic polymorphonuclear (PMN) neutrophils.1It has been found in human spleen and bone marrow.2RCTR1 is produced via lipoxygenase-mediated oxidation of DHA to 7(S)-8-epoxy-17(S)-HDHA, which is conjugated to glutathione.1,2,3RCTR1 (10 nM) increases phagocytosis ofE. colior apoptotic neutrophils in isolated human monocyte-de...
T65199	(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-6-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)hexanoic acid
	(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-6-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)hexanoic acid 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65199，CAS号为 146987-10-2。
T35452	β-Defensin-3 (human) (trifluoroacetate salt)
	β-Defensin-3 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. It inhibits the growth of the periodontopathogenic and cariogenic bacteria F. nucleatum, S. mutans, S. sobrinus, S. salivarius, and L. casei (MICs = 12.5-100 mg/l). It also inhibits the growth of S. aureus, S. pyogenes, P. aeruginosa, E. coli, and C. albicans. β-Defensin-3 stimulates gene expression and production of IL-6, IL-10, CXC...
T83661	17(R,S)-Benzo-Resolvin D1 17(R,S)-Benzo-RvD1,Benzo-RvD1
	17(R,S)-Benzo-resolvin D1 (benzo-RvD1) 是专门的分辨介质 (SPM) RvD1 的衍生物。在10和100 nM的浓度下，它能减少PDGF-BB诱导的人类血管平滑肌细胞 (VSMCs) 的细胞骨架变化，并抑制PDGF诱导的这些细胞的迁移。Benzo-RvD1 (10 nM) 抑制人脐静脉内皮细胞 (HUVECs) 中的p65核转位。它还提高了RAW 264.7对S. aureus和zymosan颗粒的吞噬作用。
T32669	Leucomycin a5 Leukomycin A5,Turimycin H4
	Leucomycin a5 is a metabolite from the leucomycin complex, which was originally isolated from S. kitasatoensis. It is active against a variety of Gram-positive and Gram-negative bacteria (MICs = 0.04-0.8 µg/ml) but not against K. pneumoniae, S. typhimuriu
T35453	β-Defensin-4 (human) (trifluoroacetate salt)
	β-Defensin-4 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. It induces migration of monocytes in vitro when used at a concentration of 10 nM but does not affect migration of neutrophils and eosinophils. β-Defensin-4 (30 μg/ml) stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3α, and RANTES by keratinocytes. It also stimulates calcium mobilization, migration, and pro...
T40119	TC-2559 difumarate
	TC-2559 idifumarate is a CNS-selective, orally active α4β2 subtype of nicotinic acetylcholine receptor (nAChR) partial agonist with an EC 50 of 0.18 μM. It exhibits selectivity for α4β2 receptors over α2β4, α4β4, and α3β4 receptors, with EC 50 s ranging from 10 to 30 μM. TC-2559 difumarate also demonstrates antinociceptive effects.
T61602	Anticancer agent 35
	Anticancer agent 35 (compound 10) 是一种磺酰脲类衍生物，一种有效的抗癌剂。Anticancer agent 35 抑制 A549、A431、PACA2 细胞生长，IC50分别为 18.1 μg/mL、4.0 μg/mL、18.9 μg/mL。
T83907	10-Chloroestra-1,4-diene-3,17-dione 10-chloro-1,4-Estradiene
	10-Chloroestra-1,4-diene-3,17-dione 是一个对雌性激素受体α (ERα) 具有激动作用的类固醇。它能增加在S. cerevisiae 中报告基因的表达（对人类受体的EC50 = 0.36 nM）。同时，它也是一种芳香化酶抑制剂（IC50 = 2.4 µM）。
T83833	Rp-2'-Deoxyuridine-5'-O-(1-thiotriphosphate) sodium Rp-dUTP-α-S
	Rp-2'-Deoxyuridine-5'-O-(1-thiotriphosphate) (Rp-dUTP-α-S) 是含硫核苷酸 dUTP-α-S 的同分异构体，也是嘌呤P2Y2受体的激动剂。在表达P2Y2受体的1321N1星形胶质瘤细胞中，该化合物特异性诱导肌醇磷酸积累（EC50 = 12.5 µM），相较于表达P2Y4的1321N1细胞，在10 µM浓度下效果更显著。
T80368	Im5
	Im5 是一种具有针对 Escherichia coli、Staphylococcus aureus、Bacillus subtilis 的抗菌活性（MIC:10、2.5-5、0.5-1 μM)的抗菌肽，同时表现出溶血性（EC50: 28 μM）。
T36073	S-Acetyl-L-glutathione
	S-Acetyl-L-glutathione is a derivative of glutathione .1 It increases intracellular GSH levels in primary fibroblasts derived from patients with glutathione synthetase deficiency when used at a concentration of 50 μM. S-Acetyl-L-glutathione (5 mM) induces apoptosis in Daudi, Raji, and Jurkat lymphoma cells.2 It inhibits the replication of herpes simplex virus 1 (HSV-1) in human foreskin fibroblasts when used at concentrations of 5 and 10 mM.3 S-Acetyl-L-glutathione (6.25 μg/g per day) increases ...

化合物

Cat.No: T60123

Synonym: (S)-9-Allyl-10-hydroxycamptothecin,吉米替康

Target: Topoisomerase

9(S),10(S),13(S)-TriHOME

Cat.No: T37863

Cat.No: T35447

10(S),17(S)-DiHDHA

Cat.No: T37488

(S,R,S)-AHPC-Me-C10-NH2 hydrochloride

Cat.No: T18669L

Synonym: (S,R,S)-AHPC-Me-C10-NH2盐酸盐

Target: Ligand for E3 Ligase

(S,R,S)-AHPC-C10-NH2

Cat.No: T17881

Synonym: VH032-C10-NH2

Target: Others, Ligand for E3 Ligase

7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid

Cat.No: T36999

Cat.No: T32781

Synonym: Phospholipid - stabilized soybean oil,Intralipid,Intralipid 20,Medialipid,Lipofundin S 10

Polyglyceryl-10 stearate

Cat.No: T34106

Synonym: Polyaldo 10-1-S,Decaglyceryl monostearate,Nikkol decaglyn 1-SV EX,Nikkol decaglyn 1-SV,Nikkol decaglyn 1-S

(S,R,S)-AHPC-Me-C10-NH2

Cat.No: T18669

Target: Others

(S,R,S)-AHPC-C10-NH2 dihydrochloride

Cat.No: T18661

Synonym: VH032-C10-NH2 dihydrochloride,VH032-linker 10,(S,R,S)-AHPC-C10-NH2二盐酸盐,VH032 amide-alkylC10-amine

Target: Others, Ligand for E3 Ligase

(S,R,S)-AHPC-Me-C10-Br

Cat.No: T18668

Target: Others

(S,R,S)-AHPC-PEG2-C4-Cl

Cat.No: T17910

Synonym: E3 ligase Ligand-Linker Conjugates 10,VHL Ligand-Linker Conjugates 7,VH032-PEG2-C4-Cl

Target: Others

(S,R,S)-AHPC-PEG6-C4-Cl

Cat.No: T17926

Synonym: VHL Ligand-Linker Conjugates 10,E3 ligase Ligand-Linker Conjugates 9,VH032-PEG6-C4-Cl

Target: Others

Cat.No: T2303

Synonym: BIBW2992,阿法替尼

Target: EGFR, HER

Cat.No: T2012

Synonym: PF-03394197

Target: JAK

Cat.No: T20828

Synonym: Cipram,Lu 10-171,Lu-10-171 Lu10-171

Target: 5-HT Receptor

Cat.No: T19649

Synonym: PF 6273340,PF 06273340,PF6273340,PF-6273340

Target: Trk receptor

Cat.No: T1850

Synonym: AAE581,巴利卡替

Target: Cysteine Protease

Cat.No: T2368L

Synonym: Lixiana,依杜沙班

Target: Factor Xa, Thrombin

Cat.No: T0153

Synonym: 吡噻硫酮,NSC 347901,RP 35972

Target: HIF/HIF Prolyl-Hydroxylase, HIV Protease, Reverse Transcriptase, Nrf2, HIF

Cat.No: T62694

Dihydronovobiocin

Cat.No: T37721

Cat.No: T28391

Synonym: PF9404C

Trichostatin A S-isomer

Cat.No: T29007

Synonym: (-)-Trichostatin A

LL-37 (18-37) (human) TFA

Cat.No: T83699

Synonym: KR-20,hCAP-18,CAP-18,Cathelicidin,FALL-39

Capreomycin free base

Cat.No: T71449

10'-Desmethoxystreptonigrin

Cat.No: T35607

10-hydroxy Warfarin

Cat.No: T36769

Cat.No: T80407

(S)-3-(1-(Dimethylamino)ethyl)phenol

Cat.No: T65737

Cat.No: T77920

Target: PROTACs

SARS-CoV-2-IN-51

Cat.No: T78765

Target: SARS-CoV

Cat.No: T37157

(S)-N,N-Dimethyl-1,2,4,5,6,7-hexahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-12-amine

Cat.No: T67218

Cat.No: T38289

Synonym: Leucomycin A13

Cat.No: T11138

Target: Others

Lanopepden camsylate

Cat.No: T70642

Cat.No: T37166

(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-6-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)hexanoic acid

Cat.No: T65199

β-Defensin-3 (human) (trifluoroacetate salt)

Cat.No: T35452

17(R,S)-Benzo-Resolvin D1

Cat.No: T83661

Synonym: 17(R,S)-Benzo-RvD1,Benzo-RvD1

Cat.No: T32669

Synonym: Leukomycin A5,Turimycin H4

β-Defensin-4 (human) (trifluoroacetate salt)

Cat.No: T35453

TC-2559 difumarate

Cat.No: T40119

Anticancer agent 35

Cat.No: T61602

10-Chloroestra-1,4-diene-3,17-dione

Cat.No: T83907

Synonym: 10-chloro-1,4-Estradiene

Rp-2'-Deoxyuridine-5'-O-(1-thiotriphosphate) sodium

Cat.No: T83833

Synonym: Rp-dUTP-α-S

Cat.No: T80368

S-Acetyl-L-glutathione

Cat.No: T36073

Cat. No.	Product Name	Target	Signaling Pathways
T2764	(S)-10-Hydroxycamptothecin 10-羟喜树碱,10-羟基喜树碱,10-Hydroxycamptothecin,10-HCPT	Apoptosis; Topoisomerase	Apoptosis; DNA Damage/DNA Repair
	(S)-10-Hydroxycamptothecin (10-HCPT) 是一种从喜树中分离的 DNA 拓扑异构酶 I 抑制剂。它显著诱导细胞凋亡，可研究肝癌、胃癌、结肠癌和白血病。
T4839	Ac-Ala-OH N-Acetylalanine,N-Acetyl-L-alanine,N-乙酰-L-丙氨酸	Others; Endogenous Metabolite	Metabolism; Others
	Ac-Ala-OH (N-Acetyl-L-alanine) 是鸟嘌呤核苷酸结合蛋白G(I)/G(S)/G(O) γ -2亚基、髓鞘碱性蛋白、GTP-结合核蛋白 Ran、原肌球蛋白 α - 4链、HIV-1 Rev 结合蛋白2、Xaa-Pro 二肽酶、胸腺酶 β -10、肌动蛋白样蛋白3、丙氨酸转氨酶、丝氨酸/苏氨酸蛋白磷酸酶PP1 - β催化亚基、10 kda 热休克蛋白(线粒体)、钙调蛋白和 β -1-syntrophin 的底物。
T0486L	Irinotecan Hydrochloride 盐酸伊立替康,伊立替康盐酸盐,Camptothecin 11 hydrochloride,CPT-11 hydrochloride	Topoisomerase; Autophagy	Autophagy; DNA Damage/DNA Repair
	Irinotecan Hydrochloride (CPT-11 hydrochloride) 是喜树碱半合成衍生物的盐酸盐，是一种拓扑异构酶 I 抑制剂，可研究结肠癌和直肠癌。
T83518	(S)-O-Methylencecalinol
	(S)-O-Methylencecalinol (compound 10)，一种从Ageratina grandfolia地上部分分离得到的化合物，目标是钙调素。
TN5264	Xanthoxyletin	TNF; NOS; ROS; COX; Antifection	Apoptosis; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Xanthoxyletin shows potent antibacterial, fungicidal, and algicidal properties, it also has anticancer, and anti-inflammatory activities. It shows an inhibitory effect on iNOS protein expression at 10 microM, it also can inhibit the synthesis of nitric oxide and the protein expression of tumor necrosis factor-alpha and cyclooxygenase-2. Xanthoxyletin induces S phase arrest and apoptosis in human gastric adenocarcinoma SGC-7901 cells, the effects are associated with the DNA damage, apoptosis thro...
T38097	Antibiotic PF 1052
	Antibiotic PF 1052 is a fungal metabolite originally isolated from Phoma.1,2 It is active against S. aureus, S. parvulus, and C. perfringens (MICs = 3.13, 0.78, and 0.39 μg/ml, respectively), among others.1 It inhibits neutrophil migration in a wound assay using zebrafish larvae expressing GFP-labeled neutrophils, reducing pseudopodia formation and inducing rounding of neutrophils.2 Antibiotic PF 1052 is selective for neutrophil migration over macrophage migration in zebrafish larvae. It also in...
T83693	Magainin 2 TFA MG2
	Magainin 2是一种从非洲爪蟾（X. laevis）皮肤中分离出的阳离子肽，具有宿主防御和抗菌活性。该化合物对细菌E. coli、K. pneumoniae、S. epidermidis、S. aureus及真菌C. albicans表现出活性（MICs分别为5、10、10、50和80 µg/ml）。Magainin 2（20 µM）能降低猕猴桃花粉的萌发率和平均管长。在被单纯疱疹病毒1型（HSV-1）或2型（HSV-2）感染的Vero细胞中，它可减少病毒复制（EC50s分别为22.16和19.8 µM），同时不影响细胞活性，其50%细胞毒性浓度值（CC50）大于100 µM。
T37609	(rel)-Asperparaline A
	Aspergillimide is a fungal metabolite originally isolated from A. japonicus.1 It reduces nicotinic acetylcholine receptor (nAChR) peak and slowly-desensitizing amplitudes induced by acetylcholine in silkworm (B. mori) larval neurons (IC50s = 20.2 and 39.6 nM, respectively) but has no effect on chicken α3β4-, α4β2-, and α7-containing nAChRs.2 Dietary administration of aspergillimide A (10 μg/g of diet) induces paralysis in silkworm fourth instar larvae.1 Aspergillimide A (10 and 20 mg/kg) reduces...
T35609	19-O-Acetylchaetoglobosin A
	19-O-Acetylchaetoglobosin A is a fungal metabolite originally isolated fromC. globosumthat has actin polymerization inhibitory and cytotoxic activities.1,2It inhibits actin polymerization in a cell-free assay when used at a concentration of 2 μM.219-O-Acetylchaetoglobosin A (3.2, 10, and 32 μg/ml) is cytotoxic to HeLa cervical cancer cells.1 1.Umeda, M., Ohtsubo, K., Saito, M., et al.Cytotoxicity of new cytochalasans from Chaetomium globosumExperientia31(4)435-438(1975) 2.Sekita, S., Yoshihira, ...
TN5228	Vestitol	Antifection	Microbiology/Virology
	Vestitol is a phytoalexin with insect feeding-deterrent activity, it has antioxidant, anti-inflammatory and antimicrobial activities, it can inhibit neutrophil migration at a dose of 10 mg/kg, and shows MICs ranging from 25-50 to 50-100 ug/mL and MBCs ranging from 25-50 to 50-100 ug/mL.Vestitol exerts a limited inhibitory effect on S. hermonthica germination, it can significantly inhibit seedling growth, it also contributes, at least in part, to the host's defence mechanism and acts as a chemica...
T38258	Phanerosporic Acid
	Phanerosporic acid is a fungal secondary metabolite originally isolated from P. chrysosporum that has antibacterial activity against B. cereus, B. subtilis, and E. coli and antifungal activity against S. cerevisiae, A. niger, O. ulmi, U. maydis, C. cucmerinum, C. cladosporioides, and B. cinerea.1 It has been used in the synthesis of macrolide derivatives.References1. Arnone, A., Assante, G., Nasini, G., et al. Phanerosporic acid, a β-resorcylate obtained from Phanerochaete chrysosporium. Phytoch...
T36226	Beauveriolide I
	Beauveriolide I is a cyclodepsipeptide that has been found inBeauveriaand an inhibitor of lipid droplet formation.1It inhibits lipid droplet formation when used at concentrations of 3 and 10 μM, as well as inhibits cholesterol synthesis (IC50= 0.78 μM), in primary mouse peritoneal macrophages.1,2Beauveriolide I also inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in mouse macrophage membranes (IC50= 6 μM).2 1.Namatame, I., Tomoda, H., Si, S., et al.Beauveriolides, specific i...
T35409	(+)-δ-Cadinene	Apoptosis; Antibacterial	Apoptosis; Microbiology/Virology
	(+)-δ-Cadinene 是一种从G. hirsutum 中发现的倍半萜，具有抗菌、杀虫、抗癌和抗增殖活性。它对肺炎双球菌的MIC 值为31.25 μg/ml，对 A. stephensi、A. aegypti 和 C. quinquefasciatust 三龄幼虫的LC50s 值分别8.23、9. 2和3。(+)-δ-Cadinene（10、50 和 100 μM）可诱导 OVCAR-3 人类卵巢癌细胞凋亡并抑制其增殖。
T36227	Beauveriolide III
	Beauveriolide III is a cyclodepsipeptide that has been found inBeauveriaand an inhibitor of lipid droplet formation.1It inhibits lipid droplet formation when used at concentrations of 3 and 10 μM, as well as inhibits cholesterol synthesis (IC50= 0.41 μM), in primary mouse peritoneal macrophages.1,2Beauveriolide III also inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in mouse macrophage membranes (IC50= 5.5 μM).2Beauveriolide III (25 and 50 mg/kg) reduces the size of aortic ...
T37272	9(S),12(S),13(S)-TriHOME
	9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble epoxide hydrolase-independent manner.1,59(S),12(S)13(S)-TriHOME inhibits antigen-induced β-hexosaminidase release from RBL-2H3 mast cells (IC50= 28.7 μg/ml).2It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50= 40.95 μM).3In vivo, 9(S),12(S),13(S)-TriHOME...
T36448	(E)-Ajoene
	(E)-Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities.1,2,3,4It is active against Gram-positive and Gram-negative bacteria (MICs = 10-250 and 150->500 μg/ml, respectively) and fungi (MICs = 15-50 μg/ml).1(E)-Ajoene inhibits proliferation of a variety of cancer cells, including MDA-MB-231 breast, HeLa cervical, and WHCO1 esophageal cancer cells (IC50s = 18.6, 61, and 39.2 μM, respectively).2It also inhibits human glutathione reductase andT. cruzitrypanoth...

天然产物

(S)-10-Hydroxycamptothecin

Cat.No: T2764

Synonym: 10-羟喜树碱,10-羟基喜树碱,10-Hydroxycamptothecin,10-HCPT

Target: Apoptosis, Topoisomerase

Cat.No: T4839

Synonym: N-Acetylalanine,N-Acetyl-L-alanine,N-乙酰-L-丙氨酸

Target: Others, Endogenous Metabolite

Irinotecan Hydrochloride

Cat.No: T0486L

Synonym: 盐酸伊立替康,伊立替康盐酸盐,Camptothecin 11 hydrochloride,CPT-11 hydrochloride

Target: Topoisomerase, Autophagy

(S)-O-Methylencecalinol

Cat.No: T83518

Cat.No: TN5264

Target: TNF, NOS, ROS, COX, Antifection

Antibiotic PF 1052

Cat.No: T38097

Cat.No: T83693

Synonym: MG2

(rel)-Asperparaline A

Cat.No: T37609

19-O-Acetylchaetoglobosin A

Cat.No: T35609

Cat.No: TN5228

Target: Antifection

Phanerosporic Acid

Cat.No: T38258

Beauveriolide I

Cat.No: T36226

(+)-δ-Cadinene

Cat.No: T35409

Target: Apoptosis, Antibacterial

Beauveriolide III

Cat.No: T36227

9(S),12(S),13(S)-TriHOME

Cat.No: T37272

Cat.No: T36448

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02450	Cathepsin D Protein, Human, Recombinant (His) HEL-S-130P,CLN10,cathepsin D,CP	Human	HEK293 Cells
	Cathepsin D Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44 kDa and the accession number is P07339.
TMPY-01431	L1CAM Protein, Human, Recombinant (His) N-CAM-L1,MASA,HSAS,L1 cell adhe	Human	HEK293 Cells
	L1CAM Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 125 kDa and the accession number is P32004-1.
TMPY-02519	BLVRB Protein, Human, Recombinant (His) HEL-S-10,biliverdin reductase B,F...	Human	E. coli
	Biliverdin reductase (hBVR) is a serine/threonine kinase that catalyzes reduction of the heme oxygenase (HO) activity product, biliverdin, to bilirubin. BVR consists of an N-terminal dinucleotide-binding domain (Rossmann-fold) and a C-terminal domain that contains a six-stranded β-sheet that is flanked on one face by several α-helices. The C-terminal and N-terminal domains interact extensively, forming the active site cleft at their interface. Biliverdin reductase (BVR) catalyzes the last step i...
TMPK-00811	L1CAM Protein, Mouse, Recombinant (His) CALL,MGC132578,FLJ44930,NCAM-L1,MIC5,CHL-1,SPG1,H	Mouse	HEK293 Cells
	L1 cell adhesion molecule (L1CAM) is one of the first neural adhesion molecules described with important functions in the development of the nervous system. Subsequent work discovered that L1CAM is expressed in many human cancers and is often associated with bad prognosis. This is most likely due to the motility and invasion promoting function of L1CAM. L1CAM is a valuable diagnostic/prognostic marker and an attractive target for the therapy of several human cancers.
TMPY-02208	Peroxiredoxin 5 Protein, Human, Recombinant (His) B166,HEL-S-55,prx-V,ACR1,PMP20,AOEB166,SBB...	Human	E. coli
	Peroxiredoxin 5 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 18.5 kDa and the accession number is P30044-2.
TMPY-02217	HSC70 Protein, Human, Recombinant (His) HSP73,HSC54,HSP71,NIP71,LAP-1,HEL...	Human	E. coli
	HSPA8, also known as HSC70, is a member of the heat shock protein family due to homology with other heat shock proteins. The heat shock protein 70 family is comprised of both heat-inducible and constitutively expressed members. The latter are called heat-shock cognate proteins. HSPA8 belongs to the heat-shock cognate subgroup. Members of the human heat-shock protein multigene family have several highly conserved proteins with structural and functional properties in common but vary in the extent ...
TMPY-06857	L1CAM Protein, Human, Recombinant (hFc) N-CAM-L1,NCAM-L1,N-CAML1,MASA,HSAS	Human	HEK293 Cells
	L1CAM Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 149.93 kDa and the accession number is NP_000416.1.
TMPY-06759	L1CAM Protein, Human, Recombinant (His & Avi), Biotinylated CAML1,SPG1,MIC5,HSAS,N-CAM-L1,L1 ...	Human	HEK293 Cells
	L1CAM Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 126.46 kDa and the accession number is NP_000416.1.
TMPK-00016	Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi), Biotinylated Hsp10,Chaperonin 10,HSPE...	Human,Mouse,Goat	E. coli
	Cpn10/HSPE, a 10-kDa heat shock protein, is a novel interacting partner of NPAT. A pool of Cpn10 is colocalized with NPAT foci during G1 and S phases in nuclei.Cpn10 is important for S phase progression and cell proliferation. Interaction of Heat Shock Protein Cpn10 with the Cyclin E/Cdk2 Substrate Nuclear Protein Ataxia-Telangiectasia (NPAT) Is Involved in Regulating Histone Transcription. Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi), Biotinylated is expressed in E. coli expre...
TMPK-00015	Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi) GROES,Hsp10,Chaperonin 10	Human,Mouse,Goat	E. coli
	Cpn10/HSPE, a 10-kDa heat shock protein, is a novel interacting partner of NPAT. A pool of Cpn10 is colocalized with NPAT foci during G1 and S phases in nuclei.Cpn10 is important for S phase progression and cell proliferation. Interaction of Heat Shock Protein Cpn10 with the Cyclin E/Cdk2 Substrate Nuclear Protein Ataxia-Telangiectasia (NPAT) Is Involved in Regulating Histone Transcription. Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi) is expressed in E. coli expression system w...
TMPY-01306	DNMT2 Protein, Human, Recombinant (GST) PUMET,RNMT1,tRNA aspartic acid methyltrans...	Human	Baculovirus Insect Cells
	DNMT2, also known as tRNA (cytosine-5-)-methyltransferase, DNA methyltransferase homolog HsaIIP, and TRDMT1, is a member of the DNA methyltransferase family of enzymes. DNMT2 enzymes have been widely conserved during evolution and contain all of the signature motifs of DNA (cytosine-5)-methyltransferases. It contains all 10 sequence motifs that are conserved among m(5)C MTases, including the consensus S:-adenosyl-L-methionine-binding motifs and the active site ProCys dipeptide, and its structure...
TMPY-02300	BIN1 Protein, Human, Recombinant (His) AMPHL,bridging integrator 1,AMPH2,SH3P9	Human	E. coli
	Amphiphysin 2, also named bridging integrator-1 (BIN1) or SH3P9, Amphiphysin2/BIN1 is a crescent-shaped N-BAR protein playing a key role in forming deeply invaginated tubes in muscle T-tubules, has been recently implicated in rare and common diseases affecting different tissues and physiological functions. BIN1 downregulation is linked to cancer progression and also correlates with ventricular cardiomyopathy and arrhythmia preceding heart failure. Increased BIN1 expression is linked to increased...
TMPY-05760	DR3/TNFRSF25 Protein, Human, Recombinant (hFc), Biotinylated TRAMP,tumor necrosis factor receptor s...	Human	HEK293 Cells
	DR3/TNFRSF25 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.9 kDa and the accession number is Q93038-10.
TMPY-00961	ADAM15 Protein, Human, Recombinant (His) MDC15,ADAM metallopeptidase domain 15	Human	HEK293 Cells
	ADAM15 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 54 kDa and the accession number is Q13444-10.
TMPY-01751	DR3/TNFRSF25 Protein, Human, Recombinant (hFc) TRAMP,TR3,WSL-1,TNFRSF12,DR3,WSL-...	Human	HEK293 Cells
	DR3/TNFRSF25 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.9 kDa and the accession number is Q93038-10.

重组蛋白

Cathepsin D Protein, Human, Recombinant (His)

Cat.No: TMPY-02450

Species: Human

Expression System: HEK293 Cells

L1CAM Protein, Human, Recombinant (His)

Cat.No: TMPY-01431

Species: Human

Expression System: HEK293 Cells

BLVRB Protein, Human, Recombinant (His)

Cat.No: TMPY-02519

Species: Human

Expression System: E. coli

L1CAM Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00811

Species: Mouse

Expression System: HEK293 Cells

Peroxiredoxin 5 Protein, Human, Recombinant (His)

Cat.No: TMPY-02208

Species: Human

Expression System: E. coli

HSC70 Protein, Human, Recombinant (His)

Cat.No: TMPY-02217

Species: Human

Expression System: E. coli

L1CAM Protein, Human, Recombinant (hFc)

Cat.No: TMPY-06857

Species: Human

Expression System: HEK293 Cells

L1CAM Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-06759

Species: Human

Expression System: HEK293 Cells

Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00016

Species: Human,Mouse,Goat

Expression System: E. coli

Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi)

Cat.No: TMPK-00015

Species: Human,Mouse,Goat

Expression System: E. coli

DNMT2 Protein, Human, Recombinant (GST)

Cat.No: TMPY-01306

Species: Human

Expression System: Baculovirus Insect Cells

BIN1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02300

Species: Human

Expression System: E. coli

DR3/TNFRSF25 Protein, Human, Recombinant (hFc), Biotinylated

Cat.No: TMPY-05760

Species: Human

Expression System: HEK293 Cells

ADAM15 Protein, Human, Recombinant (His)

Cat.No: TMPY-00961

Species: Human

Expression System: HEK293 Cells

DR3/TNFRSF25 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-01751

Species: Human

Expression System: HEK293 Cells

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