89
21
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7413 |
JNJ-5207852
|
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
JNJ-5207852 是一种新型的非咪唑组胺 H3 受体拮抗剂,其对大鼠和人 H3 受体的 pKi 值分别为 8.9 和9.24。 | |||
T8822 |
JNJ-5207852 dihydrochloride
|
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
JNJ-5207852 dihydrochloride 是一种新型的非咪唑组胺 H3 受体拮抗剂,对大鼠和人类 H3受体的 pKi 值分别为 8.9 和 9.24。 | |||
T7766 |
Remdesivir
瑞德西韦,GS-5734 |
SARS-CoV; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Remdesivir (GS-5734) 是一种核苷类似物,一种广谱的抗病毒化合物,通过抑制病毒的 RNA 依赖性 RNA 聚合酶发挥活性。Remdesivir 对埃博拉病毒、SARS 病毒、MERS病毒等均有活性,对 COVID-19 有潜在治疗价值。 | |||
T6133 |
Remodelin hydrobromide
Remodelin,Remodelin HBR |
RAAS; Histone Acetyltransferase | Chromatin/Epigenetic; Endocrinology/Hormones |
Remodelin hydrobromide (Remodelin HBR) 是一种新型有效的选择性乙酰转移酶蛋白 NAT10 抑制剂,能改善早衰综合征细胞表型。 | |||
T2923 |
Apremilast
阿普斯特,CC-10004,阿普司特 |
Apoptosis; TNF; PDE | Apoptosis; Metabolism |
Apremilast (CC-10004) 是一种口服有效的磷酸二酯酶 4 抑制剂,IC50为 74 nM。它抑制脂多糖释放TNF-α,IC50为 104 nM。 | |||
T16729 |
Remetinostat
SHP-141 |
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Remetinostat (SHP-141) 是一种基于异羟肟酸的组蛋白脱乙酰酶抑制剂,可用于治疗皮肤 T 细胞淋巴瘤的研究。 | |||
T34286 |
Remogliflozin etabonate
GSK189075,GSK 189075,GSK-189075A,GSK189075A,GSK-189075,GSK 189075A |
SGLT | GPCR/G Protein |
Remogliflozin etabonate (GSK189075A) 是 regaliflozin 的前药和 SGLT2 抑制剂,对 hSGLT2、rSGLT2、rSGLT1 和 hSGLT1 的 Ki 值分别为 1.95、2.14、8.57 和 43.1μM。 | |||
T23232 |
Remoxipride hydrochloride
Remoxipride Hydrochloride Anhydrous,Roxiam,(S)-Remoxipride Hydrochloride |
Dopamine Receptor | GPCR/G Protein; Neuroscience |
Remoxipride hydrochloride (Roxiam) 是一种选择性的 D2 受体拮抗剂,对 D2 受体、D1 受体和 α1-肾上腺素能受体的 IC50 分别为 1.57 μM、>100 μM 和 42 μM。 | |||
T2429 |
Olverembatinib dimesylate
GZD824 Dimesylate,HQP1351 |
Bcr-Abl | Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Olverembatinib dimesylate (GZD824 Dimesylate) 是一种高效的、口服具有活性的pan-Bcr-Abl 抑制剂,具有抗肿瘤活性。它能广泛而有效地抑制突变型 Bcr-Abl。它对天然的 Bcr-Abl 和 Bcr-AblT315I 作用的IC50值分别为 0.34 nM 和 0.68 nM。 | |||
T23116 |
Oxotremorine sesquifumarate
|
AChR | Neuroscience |
Oxotremorine sesquifumarate 是一种毒蕈碱受体激动剂,对 M2 的激活作用更强,可用于神经学研究。 | |||
T7608 |
Bremelanotide Acetate
bremelanotide,PT-141 Acetate |
Melanocortin Receptor | GPCR/G Protein; Neuroscience |
Bremelanotide Acetate (PT-141 Acetate) 是 α-MSH 的合成肽类似物,是黑素皮质素受体 MC3R 和 MC4R 的激动剂,有用于性功能障碍的研究潜力。 | |||
T12612 |
(R)-Apremilast
R-阿普斯特,(R)-CC-10004 |
Others | Others |
(R)-Apremilast ((R)-CC-10004) 是一种 Apremilast 的异构体。 | |||
T12339 |
Oxotremorine M iodide
碘化氧化震颤素M,Oxotremorine methiodide |
AChR | Neuroscience |
Oxotremorine M iodide (Oxotremorine methiodide) 是 mAChR 的激动剂,可增强 NMDA 受体。 | |||
T3071 |
Olverembatinib
GZD 824 |
Bcr-Abl | Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Olverembatinib (GZD 824) 是一种高效的、口服具有活性的pan-Bcr-Abl 抑制剂,具有抗肿瘤活性。它能广泛而有效地抑制突变型 Bcr-Abl。它对天然的 Bcr-Abl 和 Bcr-AblT315I 作用的IC50值分别为 0.34 nM 和 0.68 nM。 | |||
T3499 |
Remodelin
|
Histone Acetyltransferase | Chromatin/Epigenetic |
Remodelin 是一种特异性有效的乙酰转移酶蛋白 NAT10 抑制剂。 | |||
T16991 |
Targapremir-210
TGP-210 |
Apoptosis | Apoptosis |
Targapremir-210 (TGP-210) 是一种具有选择性和有效性的 miR-210 (miRNA-210) 抑制剂,抑制 pre-miR-210 的加工,可诱导乳腺癌细胞凋亡。 | |||
T16730 |
Remibrutinib
|
BTK | Angiogenesis; Tyrosine Kinase/Adaptors |
Remibrutinib 是有效的、口服具有活力的 bruton tyrosine kinase 抑制剂 (IC50:1 nM),在血液中抑制 BTK 活性的 IC50的值为 0.23 μM。它具有研究慢性荨麻疹的潜力。 | |||
T62750 |
TREM2 agonist-2
|
Others | Others |
TREM2 agonist-2 (I-192) 是一种具有口服活性和高效性的髓系细胞触发受体 2 (TREM2) 激动剂 ,可用于研究神经退行性疾病。 | |||
T77466 |
Tremelimumab
Ticilimumab,CP-675206 |
Others | Others |
Tremelimumab 是一种细胞毒性T淋巴细胞相关抗原-4(CTLA-4)阻断抗体.Tremelimumab 常与 Durvalumab 联合使用来治疗肝癌、肺癌等实体癌。 | |||
T5555 |
Siremadlin
NVP-HDM 201 |
E1/E2/E3 Enzyme | Ubiquitination |
Siremadlin (NVP-HDM 201) 是一种有效的、可口服的、高度特异性的 p53-MDM2 相互作用抑制剂。 | |||
T10350 |
Apremilast-d5
Apremilast D5,CC-10004 D5 |
TNF; PDE | Apoptosis; Metabolism |
Apremilast D5 (CC-10004 D5) is a deuterium-labeled Apremilast. Apremilast is an orally available inhibitor of PDE-4 (IC50: 74 nM). Apremilast inhibits TNF-α release by lipopolysaccharide (IC50: 104 nM). | |||
T34285 |
Remikiren
D09038,C07465,126222-34-2,AC1O44IV,CHEMBL31601 |
||
Remikiren is a highly specific renin inhibitor with oral activity for the treatment of hypertensio. | |||
T32261 |
Janthitrem F
Janthitrem E monoacetate |
||
Janthitrem f, as a 10-0-acetyljanthitrem e or janthitrem e monoacetate, is a type ofnaphthopyran. Janthitrem F is prepared by Penicillium janthinellum. Tremorgenic mycotoxi. | |||
T71496 | Isoremoxipride hydrobromide | ||
Isoremoxipride hydrobromide is a dopamine antagonist. | |||
T34283 | Remeisterol | ||
Remeisterol is a biochemical. | |||
T35776 | Janthitrem A | ||
Janthitrem A is a mycotoxin that has been found inP. janthinellum.1It induces tremors in mice and decreases the time to fall from the rotarod when administered at a dose of 4 mg/kg.2Janthitrem A (20 μg/g) also reducesW. cervinatalarvae weight gain and food consumption. 1.Gallagher, R.T., Latch, G.C., and Keogh, R.G.The janthitrems: Fluorescent tremorgenic toxins produced by Penicillium janthinellum isolates from ryegrass pasturesAppl. Environ. Microbiol.39(1)272-273(1980) 2.Babu, J.V., Popay, A.... | |||
T31192 | Daigremontianin | ||
Daigremontianin is a bufo dienolide similar to cardioside. | |||
T77029 | Gremubamab | ||
Gremubamab (MEDI3902) 是一种人源化 IgG1kappa 抗PcrV/Psl 单克隆抗体。Gremubamab 结合 PA PcrV 蛋白和 Psl 胞外多糖 Gremubamab 具有研究铜绿假单胞菌感染的潜力。 | |||
T20467 |
Bremelanotide
PT-141,PT141,PT 141 |
||
Bremelanotide is a synthetic peptide analog of alpha-MSH and is an agonist at melanocortin receptors including the MC3R and MC4R. | |||
T79209 |
Ogremorphin
GPR68-IN-1,OGM |
||
Ogremorphin (GPR68-IN-1) 为一种GPR68抑制剂,具有170 nM的EC50值。Ogremorphin 主要用于研究自身免疫性慢性炎症疾病。 | |||
T74467 |
Remdesivir de(ethylbutyl 2-aminopropanoate)
|
||
Remdesivir de(ethylbutyl 2-aminopropanoate) 是 Remdesivir 的一种杂质,后者为一种具有抗病毒活性的核苷类似物。在 HAE 细胞针对 SARS-CoV 和 MERS-CoV 的实验中,Remdesivir 的 EC50 值为 74 nM;在针对鼠肝炎病毒的延迟脑肿瘤细胞实验中,其 EC50 值为 30 nM。此外,Remdesivir 亦被认为具有针对 2019-nCoV (COVID-19) 的研究潜力。 | |||
T32258 |
Janthitrem B
|
||
Janthitrem B is a trematoxin produced by certain isolates of Penicillium violaceum. | |||
T69731 |
Remdesivir maleate
|
||
Remdesivir, also known as GS-5734, is a prodrug form of the antiviral nucleoside analog GS-44152. Remdesivir is a broad spectrum anti-viral drug that has shown to inhibit SARS-CoV-2, in vitro and in vivo. Efficacy of remdesivir against Ebola virus has been demonstrated. Remdesivir inhibits SARS-CoV-2 replication, reduces viral load, and exerts protective effects in SARS-CoV-2 infected animals. Remdesivir also reduces the pathological process, alleviates mild symptoms, and improves pulmonary les... | |||
T124153 |
6β-Ethoxyfuranoeremophilane
|
||
6β-Ethoxyfuranoeremophilane 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T124153。 | |||
T125285 |
6β-Ethoxy-8β,10β-dihydroxyeremophil-7(11)-en-12,8α-olide
|
||
6β-Ethoxy-8β,10β-dihydroxyeremophil-7(11)-en-12,8α-olide 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T125285。 | |||
T29437 |
4-Hydroxytoremifene
4 Hydroxytoremifene,4-Hydroxy Toremifene,4-Hydroxy TOR,4OH-TOR |
||
4-Hydroxytoremifene is a selective estrogen receptor modulator toremifene active metabolite. | |||
T32260 |
Janthitrem E
|
||
Janthitrem E is a type of naphthopyran. Janthitrem E is obtained from Penicillium janthinellum. Tremorgenic mycotoxi. | |||
T11196 |
Enazadrem
|
Lipoxygenase | Metabolism |
Enazadrem is a 5-lipoxygenase inhibitor with antiinflammatory activities. | |||
T32851 |
Lolitrem B
|
||
Lolitrem B is one of many toxins produced by a fungus called Epichloë festucae (var. lolii), which grows in perennial ryegrass. The fungus is symbiotic with the ryegrass; it doesn't harm the plant, and the toxins it produces kill insects that feed on ryeg | |||
T32262 | Janthitrem G | ||
Janthitrem G is a type of naphthopyran. Janthitrem G is obtained from Penicillium janthinellum. Tremorgenic mycotoxi. | |||
T21043 |
Apremilast, (+/-)-
Apremilast (+/-)-, |
||
Apremilast, (+/-)-, is a small molecule inhibitor of phosphodiesterase 4 (PDE4) with oral activity. It is used to treat psoriatic arthritis. | |||
T12274 |
Siremadlin (R Enantiomer)
Siremadlin R Enantiomer,HDM201 R Enantiomer,NVP-HDM201 R Enantiomer |
Others | Others |
Siremadlin R Enantiomer is the R enantiomer of Siremadlin. Siremadlin is a potent and highly specific inhibitor of MDM-2/p53. | |||
T76680 | Fremanezumab | ||
Fremanezumab (TEV-48125) 是一种人源化IgG2a 单克隆抗体,可选择性且有效地与降钙素基因相关肽 (CGRP) 结合。CGRP 是一种 37 个氨基酸的神经肽,参与偏头痛的中枢和外周病理生理事件。Fremanezumab 具有用于慢性偏头痛研究的潜力。 | |||
T77179 | Remtolumab | ||
Remtolumab (ABT-122) 是一种双变量域免疫球蛋白,可以中和肿瘤坏死因子α (TNFα) 和IL-17A。Remtolumab 显示出对 TNFα 和IL-17A 的双重抑制。Remtolumab 可用于类风湿关节炎 (RA) 研究。 | |||
T12656 |
(Rac)-Apremilast D5
(Rac)-CC-10004 D5 |
Others | Others |
(Rac)-Apremilast D5 is a deuterium-labeled version of the enantiomer (R)-Apremilast, also known as (R)-CC-10004, which itself is one specific form of Apremilast. | |||
T27584 |
Idremcinal
EM574,EM 574,EM-574 |
||
Idremcinal is a motilin receptor agonist. | |||
T39334 |
Remdesivir nucleoside monophosphate
|
||
Remdesivir nucleoside monophosphate, a metabolite of Remdesivir, is a potent antiviral compound with nucleoside analogue characteristics. It exhibits effective antiviral activity against both SARS-CoV and MERS-CoV. | |||
T126063 | 8-Oxoeremophil-6-en-12-oic aicd | ||
8-Oxoeremophil-6-en-12-oic aicd 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T126063。 | |||
T80954 |
TREM-1 inhibitory peptide M3
|
||
TREM-1 inhibitory peptide M3为一种配体依赖的TREM-1拮抗剂。该化合物能够有效抑制全身及肺部促炎细胞因子与趋化因子的产生,有助于缓解急性肺损伤。 | |||
T81299 |
Remternetug
LY3372993 |
||
Remternetug为一种人源化IgG1-kappa型单克隆抗体,针对APP (Aβ42 N3pGlu)的特定焦谷氨酸形式。该抗体能够特异性识别并结合形成淀粉样斑块的Aβ聚集体。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T36857L |
Premarin
共轭雌激素,Estrone 3-sulfate,Estrone sulfate |
Estrogen Receptor/ERR | Endocrinology/Hormones |
Premarin (Estrone 3-sulfate) 是一种硫酸雌激素,在创伤性脑损伤期间具有神经保护作用。 | |||
T15355 |
Fumitremorgin C
烟曲霉毒素c,12α-Fumitremorgin C |
BCRP; Antibacterial; Antibiotic; ABC | Membrane transporter/Ion channel; Microbiology/Virology |
Fumitremorgin C (12α-Fumitremorgin C) 是ABCG2/BRCP 的选择性抑制剂。 | |||
T80953 |
Tremulacin
|
||
Tremulacin为Populus树皮及其叶子中的关键糖苷组分。 | |||
T75457 | Septeremophilane E | ||
Septeremophilane E, 从真菌 Septoria rudbeckiae 分离得到,该真菌是盐生植物 Karelinia caspia 的植物病原体。该化合物显著抑制一氧化氮(NO)的产生。 | |||
T80952 |
Tremuloidin
|
||
Tremuloidin (Compound 2)为源自Homalium cochinchinensis的水杨酸衍生物,其对HIV-1活性表现出较弱的抑制效果。 | |||
TN5375 |
1β,10β-Epoxy-6β-isobutyryloxy-9-oxofuranoeremophilane
|
||
1beta,10beta-Epoxy-6beta-isobutyryloxy-9-oxofuranoeremophilane is a natural product from Ligularia fischeri. | |||
T72902 |
Acremonidin A
|
||
Acremonidin A 是一种有效的钙调素(CaM)抑制剂,存在于Purpureocillium lilacinum 中。Acremonidin A 与人钙调素 (hCaM) 生物传感器 hCaM M124C mBBr 结合,Kd 为 19.40 nM。 | |||
T40200 |
5-epi-Jinkoheremol
|
||
5-epi-Jinkoheremol exhibits more potent fungicidal activity than validamycin. | |||
T83555 | (3ξ,4ξ,5ξ,6ξ,7ξ,11ξ)-3,6-Dihydroxy-8-oxo-9-eremophilene-12-oic acid | ||
(3ξ,4ξ,5ξ,6ξ,7ξ,11ξ)-3,6-Dihydroxy-8-oxo-9-eremophilene-12-oic acid 是与苹果果斑病相关的Alternaria alternata ssp. tenuissima 新分离的植物毒素。 | |||
TN6059 |
Demethoxyfumitremorgin C
|
||
Demethoxyfumitremorgin C and tryprostatin B are fungal inhibitors of mammalian cell cycle progression at the G(2)/M transition. Demethoxyfumitremorgin C inhibits the proliferation of PC3 human prostate cancer cells via the intrinsic (mitochondrial) and ex | |||
T81014 |
Territrem A
|
||
Territrem A,一种由土曲霉菌分离提取的致震霉菌毒素。 | |||
TN5609 |
β-Aflatrem
Aflatrem B |
||
β-Aflatrem是一种天然产物,其产品编号为 TN5609,CAS号为 144446-23-1。β-Aflatrem可用作对照参考。 | |||
T26290 |
Tremetone
NSC-247531,NSC247531,NSC 247531 |
||
Tremetone is a potent anti-inflammatory and anti-oxidant agent. | |||
T72731 | Acremoxanthone C | ||
Acremoxantone C 是一种有效的钙调素(CaM)抑制剂,存在于 Purpureocillium lilacinum 中。Acremoxantone C 与人钙调素 (hCaM) 生物传感器 hCaM M124C mBBr 结合,Kd 为 18.25 nM。 | |||
TN4084 |
Fumitremorgin B
|
Antifection | Microbiology/Virology |
Fumitremorgen B is a mycotoxin, it exhibits a certain degree of genotoxicity, it can cause DNA damage in human lymphocytes; it shows an inhibitory activity on the cell cycle progression of mouse tsFT210 cells in the M phase, with the MIC value of 26.1 mic | |||
T12403 |
Penitrem A
|
Others | Others |
Penitrem A is a selective antagonist of BK channel with antiproliferative and anti-invasive activities against multiple malignancies. | |||
T81225 |
Salicyloyltremuloidin
|
||
Salicyloyltremuloidin为从木瓜柳(Salix chaenomeloides)叶中分离得到的葡萄糖苷。 | |||
TN3202 |
6beta-Angeloyloxy-1beta,10beta-epoxy-9-oxofuranoeremophilane
|
Others | Others |
6beta-Angeloyloxy-1beta,10beta-epoxy-9-oxofuranoeremophilane is a natural product from Ligularia songarica. | |||
T82448 |
Eremofortin B
|
||
Eremofortin B是倍半萜类化合物,由Penicillium roqueforti PR毒素(PRT)合成。 | |||
TN3351 |
Aflatrem
|
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Aflatrem is a tremorgenic mycotoxin with acute neurotoxic effects, a single low dose of aflatrem is able to induce degeneration of neuronal processes in hippocampal neurotransmitter systems. Aflatrem potentiates the gamma-aminobutyric acid (GABA)-induced | |||
T73914 |
Eremofortin A
|
||
Eremofortin A 是一种代谢产物,可以从罗氏青霉的培养物中分离出来。 |