store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Fumitremorgin C (12α-Fumitremorgin C) 是ABCG2/BRCP 的选择性抑制剂。
产品描述 | Fumitremorgin C (12α-Fumitremorgin C) is a mycotoxin and inhibits ABCG2/BRCP. |
体外活性 | Multidrug resistance (MDR) is a major problem in cancer chemotherapy. Reversal of resistance is associated with an increase in drug accumulation. Fumitremorgin C is extremely effective in reversing resistance to mitoxantrone, doxorubicin, and topotecan in multidrug-selected cell lines. Fumitremorgin C reverses mitoxantrone resistance (114-fold) and doxorubicin resistance (3-fold), in MCF-7/mtxR. Fumitremorgin C (5/AM) obviously potentiates the toxicity of doxorubicin (26-fold), mitoxantrone (93-fold), and topotecan (24-fold) in S1M1-3.2 cells. Fumitremorgin C does not reverse drug resistance in cells with elevated expression of Pgp or MRP [1]. Fumitremorgin C almost completely reverses resistance mediated by BCRP in vitro and is a pharmacological probe for the expression and molecular action of this transporter. Fumitremorgin C also enhances the toxicity of mitoxantrone and topotecan in vector-transfected MCF-7 cells (2.5–5.6 fold). It decreases the IC50 of topotecan in BCRP-overexpressing cells below that observed in the untreated vector-transfected cells [2]. |
别名 | 烟曲霉毒素c, 12α-Fumitremorgin C |
分子量 | 379.45 |
分子式 | C22H25N3O3 |
CAS No. | 118974-02-0 |
store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (131.77 mM), sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.6354 mL | 13.177 mL | 26.3539 mL | 65.8848 mL |
5 mM | 0.5271 mL | 2.6354 mL | 5.2708 mL | 13.177 mL | |
10 mM | 0.2635 mL | 1.3177 mL | 2.6354 mL | 6.5885 mL | |
20 mM | 0.1318 mL | 0.6588 mL | 1.3177 mL | 3.2942 mL | |
50 mM | 0.0527 mL | 0.2635 mL | 0.5271 mL | 1.3177 mL | |
100 mM | 0.0264 mL | 0.1318 mL | 0.2635 mL | 0.6588 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Fumitremorgin C 118974-02-0 Membrane transporter/Ion channel Microbiology/Virology BCRP Antibiotic Antibacterial ABC Breast cancer resistance protein 烟曲霉毒素c ABCG2 12a-Fumitremorgin C Inhibitor inhibit 12α-Fumitremorgin C Bacterial 12alpha-Fumitremorgin C inhibitor