57
10
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1603 |
Glipizide
CP 28720,K 4024,格列吡嗪 |
Potassium Channel; PPAR; ABC | DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism |
Glipizide (CP 28720) 是一种有效的、具有口服活性的磺酰脲类抗糖尿病试剂 (anti-diabetic agent),在 2 型糖尿病的研究中具有价值,但不适用于1 型糖尿病。Glipizide 是通过部分阻断郎格汉斯胰岛细胞中 ATP 敏感钾通道 (KATP)发挥活性 。 | |||
T15385 |
Glibornuride
|
Potassium Channel | Membrane transporter/Ion channel |
Glibornuride 是对 ATP 敏感的 K+通道 (KATP 通道) 阻滞剂,pKi 为 5.75。Glibornuride 显示抗糖尿病活性。 | |||
T6541 |
Ibutilide Fumarate
Corvert Fumarate,U70226E,富马酸伊布利特 |
Calcium Channel; Sodium Channel | Membrane transporter/Ion channel; Metabolism |
Ibutilide Fumarate (U70226E) 是一种 III 类抗心律失常药物,可作用于急性心梗阻塞。 | |||
T29457L |
5-Hydroxydecanoate sodium
|
Potassium Channel | Membrane transporter/Ion channel |
5-Hydroxydecanoate sodium 是一种选择性 ATP 敏感的 K+ (KATP) 通道阻滞剂,IC50 约为 30 μM。 它是线粒体外膜酰基辅酶A 合成酶的底物,具有抗氧化性。 | |||
TQ0150 |
Levcromakalim
(-)-Cromakalim,左色满卡林,BRL 38227 |
Potassium Channel | Membrane transporter/Ion channel |
Levcromakalim (BRL 38227) 是 一种 ATP 敏感性的 K+通道 (KATP) 激活剂。 | |||
T90604 |
PCO 400
|
||
PCO 400 是一种 comakalim 类似物,可作为一种选择性强的 ATP 敏感型 K+ 通道开放剂。 | |||
T4139 |
D-Luciferin potassium
D-Luciferin K Salt,D-Luciferin Potassium Salt,D-萤光素钾盐,D-荧光素钾盐 |
Others | Others |
D-Luciferin potassium (D-Luciferin K Salt) 是一种萤光素酶的底物,能够催化生物发光昆虫产生典型的黄绿光。 | |||
T1530 |
Mitiglinide calcium hydrate
KAD-1229 calcium hydrate,米格列奈钙,Mitiglinide calcium,S-21403 calcium hydrate |
Potassium Channel | Membrane transporter/Ion channel |
Mitiglinide calcium hydrate (S-21403 calcium hydrate) 是一种 ATP 敏感的 K+通道 (KATPchannel) 拮抗剂, 属于促胰岛素化合物。它对 Kir6.2/SUR1 复合物 (胰腺-细胞 KATP 通道) 具有高度特异性,在 2 型糖尿病中有研究价值。 | |||
T17030 |
Tegoprazan
|
ATPase; Proton pump | Membrane transporter/Ion channel |
Tegoprazan 是一种口服有效的、高选择性胃 H+/K+-ATP 酶 (H+/K+-ATPase) 抑制剂,能够控制胃酸分泌和运动,在体外检测的对猪、犬、人的 H+/K+-ATP 酶的 IC50为0.29-0.52 μM。 | |||
T26086L |
1-((3R,4S)-3-hydroxy-2,2-dimethyl-6-(phenylsulfonyl)chroman-4-yl)pyrrolidin-2-one
|
Others | Others |
1-((3R,4S)-3-hydroxy-2,2-dimethyl-6-(phenylsulfonyl)chroman-4-yl)pyrrolidin-2-one 是 Rilmakalim 的异构体,Rilmakalim 是一种钾通道打开剂 (PCO),可以激活心脏或其它组织中 ATP-敏感 K+ 通道 | |||
T6587 |
Mitiglinide Calcium
KAD-1229,米格列奈钙,S21403,米格列奈 |
ATPase; Potassium Channel | Membrane transporter/Ion channel |
Mitiglinide Calcium (KAD-1229) 是一种 ATP 敏感的 K+通道拮抗剂,具有促胰岛素的作用。Mitiglinide Calcium 对 Kir6.2/SUR1 复合物 (胰腺-细胞 KATP 通道) 具有高度特异性。Mitiglinide Calcium 在 2 型糖尿病的研究中具有价值。 | |||
T2404 |
Vonoprazan fumarate
富马酸沃诺拉赞,TAK-438 |
ATPase | Membrane transporter/Ion channel |
Vonoprazan fumarate (TAK-438) 是一种新型 P-CAB(钾竞争性酸阻滞剂),可可逆地抑制 H+/K+、ATP 酶。 | |||
T28136 |
NC-1300-B
NC1300B,NC 1300 B |
ATPase | Membrane transporter/Ion channel |
NC-1300-B 抑制 H(+)-K(+)-ATP 酶,可用于研究胃溃疡。 | |||
T16420 |
P-1075
|
Potassium Channel | Membrane transporter/Ion channel |
P-1075 是磺酰脲受体2相关的 ATP 敏感性的钾通道(SUR2-KIR6)的激活剂,EC50为 45 nM。它在兔子中通过打开线粒体 K (ATP) 通道产生活性氧,产生保护心脏的功效。 | |||
T14366 |
AZ10606120 dihydrochloride
|
P2X Receptor | Membrane transporter/Ion channel; Neuroscience |
AZ10606120 dihydrochloride 是一种可选择的、有效的、高亲和力的受体拮抗剂,在人和大鼠 P2X 7 受体上的 K D 值分别为 1.4 和 19 nM。AZ10606120 dihydrochloride 抑制肿瘤生长,具有抗血管生成活性 。AZ 10606120在与 ATP 结合位点偶联的位点结合时充当负变构调节剂。 | |||
T27624 |
Iptakalim Hydrochloride
|
Potassium Channel; AChR | Membrane transporter/Ion channel; Neuroscience |
Iptakalim hydrochloride 是一种亲脂性的对氨基化合物,是 ATP 敏感的钾通道的开放剂,也是含α4β2的烟碱乙酰胆碱受体拮抗剂。它也是一种 K(ir) 6.1/SUR2B 激活剂,可通过保护内皮功能减轻大鼠缺氧引起的肺动脉高压。 | |||
T16865 |
SCH28080
|
ATPase; Proton pump | Membrane transporter/Ion channel |
SCH28080 是一种可逆且具有 K+ 竞争性的胃 H+/K+-ATP 酶 (H+/K+-ATPase) 抑制剂,IC50 值为 20 nM (家兔微粒体膜)。SCH28080 在体内是有效的酸分泌抑制剂,具有抗溃疡活性、抗分泌和细胞保护活性。 | |||
T14052 |
5-IAF
5-Iodoacetamidofluorescein |
||
5-IAF 是吲哚乙酰胺的一种荧光素衍生物,是一种荧光探针,可用来标记蛋白质和其他含有游离硫醇(半胱氨酸侧链)。5-IAF 可标记狗肾脏Na,K-ATP 酶的催化(α)亚单位。 | |||
T8135 |
Minoxidil sulfate
Minoxidil sulphate,U-58838,米诺地尔硫酸盐 |
Potassium Channel | Membrane transporter/Ion channel |
Minoxidil sulfate (U-58838) 是米诺地尔的硫酸代谢物,是ATP 敏感的 K+通道激动剂。它被认为是血管扩张试剂,在动物实验模型中,促进头发生长。 | |||
T0712 |
Suloctidil
|
ATPase; Platelet aggregation | Membrane transporter/Ion channel; Others |
Suloctidil 是一种外周血管扩张剂,作用于大鼠脑突触, 影响Na+/ K+ ATP 酶活性和膜流动性,可治疗痴呆和血栓形成病症。 | |||
T4263 |
BAY 61-3606
2-[[7-(3,4-二甲氧基苯基)咪唑并[1,2-C]嘧啶-5-基]氨基]-3-吡啶甲酰胺,Syk inhibitor IV |
Apoptosis; Syk | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
BAY 61-3606 (Syk inhibitor IV) 是一种具有口服活性的,ATP 竞争性的可逆选择性Syk 抑制剂。它作用于乳腺癌细胞,通过下调 Mcl-1 促进 TRAIL 诱导的细胞凋亡。它降低神经母细胞瘤细胞中的 ERK1/2 和 Akt 磷酸化,也降低 K-rn 细胞裂解物中 Syk 磷酸化。 | |||
T2189 |
Sodium orthovanadate
Sodium vanadate,钒酸钠,Trisodium vanadate,Sodium pervanadate |
ATPase; Phosphatase | Membrane transporter/Ion channel; Metabolism |
Sodium orthovanadate 是一种蛋白酪氨酸磷酸酶,碱性磷酸酶和一些ATP 酶的抑制剂,有可能充当磷酸盐类似物。它具有胰岛素样作用、对心室肌的正性肌力作用和其他代谢作用。 | |||
T6700 |
Tenatoprazole
泰妥拉唑,TU-199 |
Proton pump | Membrane transporter/Ion channel |
Tenatoprazole (TU-199) 是一种口服有效的,基于咪唑吡啶的质子泵抑制剂。它抑制猪胃H+/K+-ATP 酶活性,IC50为6.2 μM。它阻断泛素与 ESCRT-1 因子 Tsg101 的相互作用,抑制几种包膜病毒的产生,包括 EBV。 | |||
T1496 |
Amiodarone hydrochloride
盐酸胺碘酮,Amiodar,Amiodarone HCl,Nexterone |
Potassium Channel; Adrenergic Receptor; Autophagy | Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience |
Amiodarone hydrochloride (Amiodarone HCl) 是一种抗心绞痛和 III 类抗心律失常药物,通过抑制钾通道和电压门控钠通道来增加心室和心房肌肉作用的持续时间,可导致心率和血管阻力降低。它通过成纤维细胞中的 ERK1/2和 p38 MAPK 信号传导诱导细胞增殖和肌成纤维细胞分化,可研究室上性和室性心律失常。 | |||
T1634 |
Glibenclamide
格列本脲,Glyburide |
Potassium Channel; Mitochondrial Metabolism; CFTR; P-gp; Autophagy | Autophagy; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Glibenclamide (Glyburide) 是一种具有口服活性的 ATP 敏感的 K+通道抑制剂,可研究糖尿病和肥胖。它抑制 P-糖蛋白,可直接结合并阻断 KATP 的 SUR1亚基并抑制囊性纤维化跨膜传导调节蛋白。它通过诱导膜离子通透性干扰线粒体生物能,可诱导自噬。 | |||
T6776 |
BAY 61-3606 dihydrochloride
BAY 61-3606,BAY-61-3606 dihydrochloride |
Apoptosis; Syk | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
BAY 61-3606 dihydrochloride (BAY 61-3606) 是一种口服有效的,ATP 竞争性的,可逆的选择性Syk 抑制剂。它降低神经母细胞瘤细胞中的 ERK1/2 和 Akt 磷酸化,也降低 K-rn 细胞裂解物中 Syk 磷酸化。它作用于乳腺癌细胞,通过下调 Mcl-1 促进 TRAIL 诱导的细胞凋亡。 | |||
T0075 |
Nicorandil
SG-75,尼可地尔 |
Potassium Channel | Membrane transporter/Ion channel |
Nicorandil (SG-75) 是一种有效的钾通道激活剂,靶向血管核苷二磷酸依赖性 K+通道和心脏 ATP 敏感 K+通道 (KATP)。Nicorandil 是一种烟酰胺酯,具有血管舒张和心脏保护作用,并具有治疗心绞痛和缺血性心脏病的潜力。 | |||
T1674 |
Nateglinide
那格列奈,A4166,Senaglinide |
Potassium Channel; Proteasome; PPAR | DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Proteases/Proteasome; Ubiquitination |
Nateglinide (Senaglinide) 是 D-苯丙氨酸的一种衍生物,是口服有效的、短效促胰岛素释放化合物,也是 DPP IV 抑制剂。 Nateglinide 抑制胰岛 β 细胞中 ATP 敏感的 K+通道。Nateglinide 在 2 型糖尿病中具有研究价值。 | |||
T17268 |
Y-26763
|
Others | Others |
Y-26763 is a K+ channel opener and active metabolite of Y-27152. This is an ATP-sensitive K+ (KATP) channel activator. | |||
T29208 |
ZD-0947
AZD0947,AZD-0947,ZD 0947,AZD 0947 |
||
ZD-0947, a K(ATP) channel activator, is used potentially for the treatment of overactive bladder (OAB). | |||
T30487 |
BMS 180448
BMS-180448,BMS180448 |
||
BMS 180448 is a prototype mitochondrial ATP-sensitive K+ (Mitok (ATP)) channel opener with cardioprotective and vasodilating properties. | |||
T24435 |
MCC-134
MCC 134,MCC134 |
||
MCC-134 is an inverse agonist for the pancreatic-type ATP-sensitive K(+) channel. It also used as a vascular relaxing agent. | |||
T26130 |
RS 029
RS029,RS-029 |
||
RS 029 is a nitroimidazole that has been exhibited to significantly inhibit (Na+K+) ATP-ase activity. | |||
T27718 |
KCO-912
|
||
KCO-912 is a potent and selective opener of ATP-dependent potassium (K ATP) channels. KCO-912 suppresses airways hyperreactivity at doses devoid of cardiovascular effects. | |||
T15386 | Glisoxepide | Others | Others |
Glisoxepide is a sulphonamide derivative and is an orally available nonselective K(ATP) channel blocker. It has antihyperglycemic activity and cardiovascular regulation effect. | |||
T27739 |
KR-31378
MSH1001,DNB 001,DNB-001,DNB001,MSH-1001,KR31378 |
||
KR-31378, a K(ATP) channel activator, is used potentially for the treatment of ocular hypertension and glaucoma. | |||
T21431 | Mitiglinide | ||
Mitiglinide (KAD-1229) 是一种促胰岛素化合物,是一种 ATP 敏感的 K+通道 (KATPchannel) 拮抗剂。Mitiglinide 对 Kir6.2/SUR1 复合物 (胰腺-细胞 KATP 通道) 具有高度特异性,具有 2 型糖尿病的治疗潜力。 | |||
T40696 |
2'-NH2-ATP
2'-NH2-ATP,2'-Amino-2'-deoxyadenosine-5'-triphosphate |
||
2'-NH2-ATP (2'-Amino-2'-deoxyadenosine-5'-triphosphate) is an adenosine derivative compound that acts as a weak competitive inhibitor of ATP with a K i value of 2.3 mM. It finds utility in nucleic acid labeling. | |||
T76374 |
SPAI-1
|
||
SPAI-1,特异性单价阳离子ATP酶抑制剂,源自猪十二指肠。能体外抑制Na+,K+-ATP酶和H+,K+-ATP酶,同时刺激Mg2+-ATP酶。 | |||
T28977 |
Tilisolol HCl
Tilisolol, trade name Selecal,N 696,N-696,N696 |
||
Tilisolol is a nonselective blocker of beta-adrenergic. Tilisolol hydrochloride dilates coronary arteries through an ATP-sensitive K(+)-channel opening mechanism in dogs. | |||
T25102 |
Aprikalim
RP52891,RP-52891,RP 52891 |
||
Aprikalim is a specific and selective ATP-sensitive K+ (KATP) channel opener. Aprikalim affords cardioprotection and at higher doses also cause peripheral or coronary vasodilatation. | |||
T40522 | 3'-Deoxy-3'-amino-ATP | ||
3'-Deoxy-3'-amino-ATP, an ATP analogue, is a highly effective and competitive inhibitor of ATP, exhibiting a K i value of 2.3 μM. Its application includes the synthesis of 3′-Amino-3′-deoxy transfer RNA by integrating it into the 3' terminus of tRNA-C-C. | |||
T15667 |
KRN4884
|
Others | Others |
KRN 4884 is an opener of the K+ channel. KRN 4884 (0.1-3 μM) activates KATP channels in a concentration-dependent manner (EC50=0.55 μM), in the presence of intracellular ATP (1 mM). | |||
T83962 |
C 101248
|
||
C 101248是一种选择性且强效的小鼠和人类串联孔道卤素抑制K+通道1(THIK-1, IC50= 50 nM)抑制剂,对K2P家族成员TREK-1和TWIK-2以及Kv2.1无活性。C 101248能够阻断小鼠海马微胶质细胞中THIK-1 K+电流的整细胞膜片钳记录中的音调和ATP激发的电流。C 101248通过防止NLRP3依赖性IL-1β的释放,从而减少在分离的微胶质细胞中的神经炎症。 | |||
T74127 | N-Desethyl Sunitinib hydrochloride | ||
N-Desethyl Sunitinib (SU-12662) (hydrochloride) 是 Sunitinib 的代谢物。Sunitinib 是有效的,ATP 竞争的VEGFR,PDGFRβ和KIT 抑制剂,能够抑制VEGFR-1,VEGFR-2,VEGFR-3,PDGFRβ和 KIT 的活性,Ki 值分别为 2,9,17,8 和 4 nM。 | |||
T75403 | Glucuronokinase (AtGlcAK) | ||
Glucuronokinase (AtGlcAK) 为GHMP激酶家族的一员。其对D-葡萄糖醛酸表现出独有的底物特异性,具有0.7 mM的Km值。Glucuronokinase (AtGlcAK) 能催化D-葡萄糖醛酸与ATP反应生成D-葡萄糖醛酸-1-磷酸和ADP。 | |||
T73445 | TIM-063 | ||
TIM-063 是一种选择性和细胞可渗透的CaMKK 抑制剂,ATP 竞争性抑制剂,可以直接靶向 CaMKK 的催化结构域,作用于 CaMKKα 和CaMKKβ 的Ki 值分别是 0.35 μM 和 0.2 μM,IC50值分别是 0.63 μM 和 0.96 μM。 | |||
T72812 |
(R)-Tegoprazan
|
||
(R)-Tegoprazan (example 3) 是一种苯并咪唑衍生物,是一种有效的胃H+/K+-ATP 酶抑制剂,对犬肾 Na+/K+-ATPase 的IC50为 98 nM。(R)-Tegoprazan 具有胃肠道疾病研究的潜力。 | |||
T38927 |
SR-1277
|
||
SR-1277 is a highly potent, selective, and ATP competitive inhibitor of CK1δ/ε, with IC50 values of 49 nM and 260 nM, respectively. Additionally, SR-1277 exhibits inhibitory effects on FLT3, CDK4/cyclin D1, CDK6/cyclin D3, and CDK9/cyclin K, with IC50 values of 305 nM, 1340 nM, 311 nM, and 109 nM, respectively. Taken together, SR-1277 represents a valuable tool for cancer research. | |||
T11038 |
Dibutyryl-cGMP sodium
Bt2cGMP sodium |
Others | Others |
Dibutyryl-cGMP sodium (Bt2cGMP sodium) is a cell-permeable cGMP analog. Dibutyryl-cGMP sodium preferentially activates cGMP-dependent protein kinase (PKG). Dibutyryl-cGMP sodium inhibits [3H]-arachidonic acid release in human platelets stimulated by gamma |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3S0870 |
Paederosidic acid methyl ester
鸡屎藤苷酸甲酯,紫草酸甲酯 |
ATPase; Potassium Channel; NO Synthase | Immunology/Inflammation; Membrane transporter/Ion channel |
Paederosidic acid methyl ester 是 ATP 敏感的 K+channel 通道激活剂,分离自 P. scandens。它通过激活脑中和脊髓水平中 ATP 敏感型 K+通道提高了痛觉阈值,表现出显著的中枢缓解疼痛活性。 | |||
Fr14207 |
(-)-Isopulegol
|
Others | Others |
(-)-Isopulegol 具有抗氧化和神经活性特性。它还具有由异胡薄荷醇诱导的胃保护作用,似乎至少部分由内源性前列腺素介导,K+ATP 通道开放和与 GSH 相关的抗氧化特性增加。 | |||
T36390 |
Sodium oleate
Oleic acid sodium salt,Sodium oleate,cis-9-Octadecenoic acid sodium salt |
ATPase | Membrane transporter/Ion channel |
Sodium oleate (cis-9-Octadecenoic acid sodium salt) (Oleic acid sodium) 是人脂肪细胞和其他组织中最常见的单不饱和脂肪酸钠盐。Sodium oleate 是一种 Na+/K+ ATP 酶激活剂。 | |||
T2O2668 |
Oleic acid
Elaidoic acid,9Z-Octadecenoic acid,Oleate,9-Octadecenoic Acid,Glycon Wo,9-cis-Octadecenoic acid,油酸 |
Apoptosis; ATPase; Others; Endogenous Metabolite | Apoptosis; Membrane transporter/Ion channel; Metabolism; Others |
Oleic acid (Glycon Wo) 属于天然产物,是一种常见的饱和脂肪酸,在存在于多种动物、植物的脂肪和油脂中。Palmitic acid 是一种 Na+/K+ATP 酶激活剂。 | |||
T8061 |
Citronellal
(±)-Citronellal,香茅醛 |
Others | Others |
Citronellal ((±)-Citronellal) 是多种芳香植物精油的单萜烯,具有促进睡眠、安定和抗伤害的作用。它可以降低机械伤害感受,且部分通过 NO-cGMP-ATP 敏感型 K⁺渠道通道介导的。 | |||
TJP2872 |
Acevaltrate
Acevaltratum,乙酰缬草三酯,Acetoxyvaltrate |
ATPase; Others | Membrane transporter/Ion channel; Others |
Acevaltrate (Acevaltratum) 对人小细胞肺癌细胞系 GLC(4) 和人结肠直肠癌细胞系 COLO 320 具有高细胞毒性,IC50 值为 1-6 uM。它抑制大鼠肾和脑半球中 Na+/K+-ATP 酶活性,IC50分别为 22.8 和 42.3 μM。 | |||
T79936 |
Forrestiacids K
|
ATP Citrate Lyase | Metabolism |
Forrestiacids K, 萜类化合物,源自Pseudotsuga forrestii,作为ATP-citrate lyase (ACL) 的抑制剂。 | |||
T79992 |
Sarglaroids F
|
Caspase | Apoptosis; Proteases/Proteasome |
Sarglaroids F(化合物6)为从草珊瑚根部提取的抗炎剂,影响K+外排并降低Caspase-1(P20)水平以抑制LPS/ATP诱导的IL-1β释放,对RAW264.7细胞无细胞毒性。 | |||
TN4322 |
Isopulegol
|
ATPase; Potassium Channel; GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Isopulegol presents depressant- and anxiolytic-like effects, it also has anticonvulsant and bioprotective effects against PTZ-induced convulsions are possibly related to positive modulation of benzodiazepine-sensitive GABAA receptors and to antioxidant properties.Isopulegol presents significant gastroprotective effects in both ethanol- and indomethacin-induced ulcer models, which appear to be mediated, at least in part, by endogenous prostaglandins, K(ATP) channel opening, and antioxidant proper... | |||
T73764 | L-Palmitoylcarnitine TFA | ||
L-Palmitoylcarnitine TFA 是一种长链酰基肉碱和脂肪酸代谢产物,在缺血期间积聚于肌膜并扰乱膜脂环境。L-Palmitoylcarnitine TFA 通过与Kir6.2的相互作用抑制KATP 通道活性,而不影响单通道电导。 |