Powder: -20°C for 3 years | In solvent: -80°C for 1 year
5-Hydroxydecanoate sodium 是一种选择性 ATP 敏感的 K+ (KATP) 通道阻滞剂,IC50 约为 30 μM。 它是线粒体外膜酰基辅酶A 合成酶的底物,具有抗氧化性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 mg | ¥ 277 | 现货 | ||
25 mg | ¥ 495 | 现货 | ||
50 mg | ¥ 795 | 现货 | ||
100 mg | ¥ 1,160 | 现货 | ||
200 mg | ¥ 1,730 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 448 | 现货 |
产品描述 | 5-Hydroxydecanoate sodium is a selective ATP-sensitive K+ (KATP) channel blocker with IC50 of about 30 μM. 5-Hydroxydecanoate sodium is a substrate for mitochondrial outer membrane acyl-CoA synthetase with antioxidant property. |
靶点活性 | K+-ATP channel:30 μM |
体外活性 | The treatment of 5-Hydroxydecanoate sodium abolished the beneficial effects of penehyclidine hydrochloride (PHC) preconditioning in anoxia/reoxygenation (A/R)‐induced injury in H9c2 cells. 5-Hydroxydecanoate sodium blocked the inhibitory effect of PHC on Ca2+ overload and ROS production and promoted the release of Cyt-C from mitochondria into cytoplasm. 5-Hydroxydecanoate sodium attenuated the anti-apoptotic effect of PHC[1]. |
体内活性 | The treatment of 5-Hydroxydecanoate sodium (100 μM) abolished the effects of ischemic preconditioning (IPC) on the contractile recovery, but 5-Hydroxydecanoate sodium did not affect its effect on the contracture, lactate production, glycogenolysis and viable tissue in rats[2]. |
分子量 | 210.25 |
分子式 | C10H19NaO3 |
CAS No. | 71186-53-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.6 mg/mL (17.12 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 4.7562 mL | 23.7812 mL | 47.5624 mL | 118.9061 mL |
5 mM | 0.9512 mL | 4.7562 mL | 9.5125 mL | 23.7812 mL | |
10 mM | 0.4756 mL | 2.3781 mL | 4.7562 mL | 11.8906 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
5-Hydroxydecanoate sodium 71186-53-3 Membrane transporter/Ion channel Potassium Channel 5 Hydroxydecanoate sodium 5Hydroxydecanoate sodium Inhibitor inhibitor inhibit