52
4
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T23513 |
VU10010
VU 10010 |
AChR | Neuroscience |
VU10010 (VU 10010) 是一种高度选择性的M4mAChR 变构增强剂,EC50为 400 nM。它与 M4mAChR 的变构位点结合,增强与 G 蛋白偶联,增加对乙酰胆碱的亲和力,还会增加卡巴胆碱引起的兴奋性传导抑制。 | |||
T1566 |
Aripiprazole
阿立哌唑,OPC-14597 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Aripiprazole (OPC-14597) 是血清素受体 5-HT1A 和多巴胺 D2 受体的部分激动剂,还用作突触后拮抗剂和血清素受体 5-HT2A 的拮抗剂。 | |||
T8702 |
SKF-83566
|
Dopamine Receptor; 5-HT Receptor; AChR | GPCR/G Protein; Neuroscience |
SKF-83566 是一种具有血脑渗透性和口服活性的 D1 样多巴胺受体拮抗剂和一种较弱的竞争性 5-HT2 受体拮抗剂,Ki 为 11 nM。它是竞争性多巴胺转运蛋白抑制剂,可用于研究帕金森氏症和对尼古丁渴望的缓解的相关研究。 | |||
T19333 |
Gadoteridol
ProHance,SQ-32692,钆特醇,Gd-HP-DO3A |
Others | Others |
Gadoteridol (Gd-HP-DO3A) 是含钆基的 MRI 造影剂,可用于中枢神经系统成像。 | |||
T4297 |
Flibanserin
BIMT-17BS,氟立班丝氨,Girosa,BIMT-17 |
Dopamine Receptor; 5-HT Receptor | GPCR/G Protein; Neuroscience |
Flibanserin (Girosa) 一种具有口服活性的 5-HT1A 受体激动剂和 5-HT2A 受体拮抗剂,Ki 值分别为 1 和 49 nM。它与多巴胺 D4 受体结合,Ki 值在 4 到 24 nM 之间。它是一种血清素能抗抑郁药,用于治疗性欲减退症。 | |||
T12617L |
(R)-CR8
(R)-CR8,(R)-Isomer,(2R)-2-[[9-异丙基-6-[[[4-(2-吡啶基)苯基]甲基]氨基]-9H-嘌呤-2-基]氨基]-1-丁醇,CR8 |
Apoptosis; CDK | Apoptosis; Cell Cycle/Checkpoint |
(R)-CR8 ((R)-Isomer) 是 Roscovitine 类似物,是CDK1/2/5/7/9抑制剂。它作为一种分子胶降解剂来消耗细胞周期蛋白 K。它诱导细胞凋亡并具有神经保护作用。 | |||
T61934 |
Repinotan
|
||
Repinotan (BAY x 3702 free base) 是有效的、选择性的、血脑屏障通透性的、口服活性的5-HT1A 受体激动剂。Repinotan 的Ki 值为 0.19 nM (小牛海马), 0.25 nM (大鼠和人类皮层) 和 0.59 nM (大鼠海马)。Repinotan 具有强效的神经保护作用。 | |||
T16816 |
S 18986
|
GluR | Neuroscience |
S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors, showcasing cognitive-enhancing properties in rodents. It induces the release of noradrenaline and acetylcholine in the rat hippocampus, leading to enhanced object-recognition memory. | |||
T5468 |
YF-2
|
Others; Epigenetic Reader Domain; Histone Acetyltransferase | Chromatin/Epigenetic; Others |
YF-2 是一种高选择性,可透过血脑屏障的组蛋白乙酰转移酶激动剂,能够在海马区乙酰化 H3,对 CBP、PCAF 和 GCN5 的EC50值分别为 2.75、29.04 和 49.31 μM,具有抗肿瘤和抗阿尔滋海默症的活性。 | |||
T11800 |
L-803087
|
Somatostatin | GPCR/G Protein |
L-803087 是一种具有高效性和选择性的生长抑素 sst4 受体激动剂,对 sst4 的 Ki 值为 0.7 nM,比其他生长抑素受体的选择性高 280 倍以上。L-803087 在体外诱导 AMPA 介导的海马突触反应,在体内增加了海藻酸盐促使的小鼠癫痫发作。 | |||
T37190 |
L-Allylglycine
|
Dehydrogenase; GABA Receptor | Membrane transporter/Ion channel; Metabolism; Neuroscience |
L-Allylglycine 是 GABA 合成酶(谷氨酸脱羧酶)的有效抑制剂。 | |||
T13975 |
ZSET-845
|
Others | Others |
ZSET-845 is an enhancer of cognitive which enhances choline acetyltransferase activity in the hippocampus in the rat. | |||
T10542 |
Bifeprunox
|
Others | Others |
Bifeprunox is a potent partial agonist of dopamine D2-like and 5-HT1A receptor (pEC50: 6.37 for hippocampus 5-HT1A; pKis: 7.19 and 8.83 for cortex 5-HT1A and striatum D2). It is an antipsychotic for the research of schizophrenia. | |||
T28139 |
NCFP
|
||
NCFP is a mGlu5 positive allosteric modulator. It positively modulates mGlu5 without the induction of long-term potentiation and long-term depression in the hippocampus. | |||
TP1685 |
Cortistatin-14 TFA (186901-48-4 free base)
Cortistatin-14 TFA |
||
Cortistatin-14 is a neuropeptide have structural similarity to somatostatin-14. It is produced in the cortex and hippocampus of central nervous system. | |||
T68059 |
Ebalzotan
|
||
NAE-086 是一种高亲和力和选择性的5-HT(1A)受体配体,其K(i)值为4.5 nM。 | |||
TP1188 |
Cortistatin 14, human, rat
CST-14, human, rat |
||
Cortistatin 14 is a somatastatin-like neuropeptide with neuronal depressant and sleep modulating properties. Cortistatin 14 is present primarily in the cortex and hippocampus. | |||
T24919 |
UBP714
UBP 714,UBP-714 |
||
UBP714 is a derivative of the NMDA receptor negative allosteric modulator UBP608. It also enhanced NMDAR mediated field EPSPs in the CA1 region of the hippocampus. UBP714 is a novel template for the development of potent and subunit selective NMDAR potent | |||
T25558 |
JNJ-55511118
JNJ 55511118 |
||
JNJ-55511118 is a selective negative modulator of AMPA receptors containing TARP-γ8 (Ki: 26 nM). It had excellent pharmacokinetic properties. JNJ-55511118 exhibited a dose-dependent inhibition of neurotransmission within the hippocampus and a strong antic | |||
T38281 |
C22 Galactosylceramide (d18:1/22:0)
|
||
C22 Galactosylceramide is a sphingolipid that has been found in the central nervous system.1,2C22 Galactosylceramide levels are increased in the spinal cord, but not the brain or liver, of mice fed a methionine-restricted diet.1C22 Galactosylceramide has been found in postmortem hippocampus from patients with Alzheimer's disease.2[Matreya, LLC.] | |||
T36178 |
Aspalatone
|
||
Aspalatone is an anti-platelet aggregator (IC50 = 180 μM, in vitro) that prolongs bleeding time significantly in a rodent model of thromboembolism. Additionally at a minimal effective dose of 24 mg/kg, aspalatone generates antioxidant and neuroprotective effects against kainic acid-induced epilepsy in rat hippocampus. | |||
T38217 |
1-Stearoyl-2-Adrenoyl-sn-glycero-3-PE
|
||
1-Stearoyl-2-adrenoyl-sn-glycero-3-PE is a phospholipid that contains stearic acid and adrenic acid at thesn-1 andsn-2 positions, respectively. 1-Stearoyl-2-adrenoyl-sn-glycero-3-PE levels are inversely correlated with subject age in mitochondria isolated from human post-mortem hippocampus.1 1.Hancock, S.E., Friedrich, M.G., Mitchell, T.W., et al.Decreases in phospholipids containing adrenic and arachidonic acids occur in the human hippocampus over the adult lifespanLipids50(9)861-872(2015) | |||
T70365 |
JTP-4819
|
||
JTP-4819 is a potent and selective prolyl endopeptidase (PEP) inhibitor with potential for treating Alzheimer's disease. At nanomolar concentration, JTP-4819 inhibited the degradation of substance P, arginine-vasopressin, and thyrotropin-releasing hormone by PEP in supernatants of the rat cerebral cortex and hippocampus. Repeated administration of JTP-4819 reversed the aging-induced decrease in brain substance P-like and thyrotropin-releasing hormone-like immunoreactivity, suggesting that this d... | |||
T38711 |
YF-2 hydrochloride
|
||
YF-2 hydrochloride is a potent histone acetyltransferase activator that exhibits high selectivity and can pass through the blood-brain barrier. It specifically acetylates H3 in the hippocampus, with EC50 values of 2.75 μM, 29.04 μM, and 49.31 μM for CBP, PCAF, and GCN5, respectively. Notably, it does not affect HDAC activity. Moreover, YF-2 hydrochloride demonstrates promising anti-cancer and anti-Alzheimer's disease properties. | |||
T61130 |
SSTR4 agonist 3
|
||
SSTR4 agonist 3 is a potent compound that activates the SSTR4 receptor. The SSTR4 receptor is highly expressed in the hippocampus and neocortex, which are regions associated with memory, learning, and Alzheimer's disease pathology. SSTR4 agonists demonstrate strong efficacy in rodent models of pain, both acute and chronic, by reducing peripheral nociception and inflammation. Considering its potential application in pain research, SSTR4 agonist 3 is of interest[1]. | |||
T70595 |
Artemisinin B
|
||
Artemisinin B is a drug which may improve spatial memory in dementia patients and alter the levels of inflammatory cytokines in the hippocampus and the cortex. Artemisinin B may inhibit neuroinflammation and exert neuroprotective effects on cognitive functions by modulating the TLR4-MyD88-NF-κB signaling pathway. Artemisinin B has shown potential in the treatment of neuroinflammatory diseases. | |||
TP1662 |
Galanin Receptor Ligand M35
|
||
The chimeric peptide M35 [galanin (1-13)-bradykinin(2-9) amide] is a high-affinity galanin receptor ligand acting as a galanin receptor antagonist in the rat spinal cord, rat hippocampus and isolated mouse pancreatic islets. The radiolabelled M35 and perf | |||
T35809 |
C20 Sphingomyelin (d18:1/20:0)
|
||
C20 Sphingomyelin is a naturally occurring sphingolipid. Levels of C20 sphingomyelin are upregulated in the hippocampus of rats with diabetes induced by streptozotocin and in human plasma where it is positively correlated with insulin resistance in obese humans. C20 sphingomyelin is also upregulated in the liver of a mouse model of Niemann-Pick type C1 disease, a neurodegenerative cholesterol-sphingolipid lysosomal storage disorder. The plasma concentration of C20 sphingomyelin is decreased in m... | |||
T37478 |
Acetyl β-Endorphin (1-26) (human) (trifluoroacetate salt)
|
||
Acetyl β-endorphin (1-26) is a neuropeptide found in rat hippocampus, brain stem, and pituitary. It is also present in the human hypothalamus, where it comprises approximately 4.9% of total β-endorphin peptides. Acetyl β-endorphin (1-26) is produced through posttranslational processing of β-endorphin and is processed similarly in rat and human hypothalamus. Levels of acetyl β-endorphin (1-26) increase in the rat pars intermedia and brain stem following chronic administration of haloperidol . | |||
T76358 |
Neuropeptide Y (1-24) (human)
|
||
Neuropeptide Y (1-24) (human) 是一种神经肽,它能够抑制大鼠输精管电刺激引发的抽搐反应,同时在体内刺激 N-methyl-D-aspartate (NMDA) 促使大鼠海马背侧 CA3 区神经元激活。 | |||
T80170 |
Tamapin
|
Potassium Channel | Membrane transporter/Ion channel |
Tamapin为靶向小电导Ca(2+)激活的K(+) (SK)通道的毒液肽,尤以钾通道SK2为选择性阻断剂。该化合物能够抑制海马锥体神经元SK通道介导的电流,来源于印度红蝎(Mesobuthus tamulus)。 | |||
T36521 |
Alaproclate (hydrochloride)
|
||
Alaproclate is a selective serotonin reuptake inhibitor (SSRI).1,2 It inhibits depletion of serotonin (5-HT) induced by 4-methyl-α-ethyl-m-tyramine in rat cerebral cortex, hippocampus, hypothalamus, and striatum (EC50s = 18, 4, 8, and 12 mg/kg, respectively).1 Alaproclate inhibits NMDA-evoked currents and depolarization-induced voltage-dependent potassium currents in rat hippocampal neurons (IC50s = 1.1 and 6.9 μM, respectively) and does not inhibit GABA-evoked currents when used at concentratio... | |||
TP2136 |
(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin
|
||
Selective vasopressin V1A receptor antagonist. Inhibits vasopressin and oxytocin-induced increases in intracellular calcium concentrations in vitro (IC50 values are 5 and 30 nM respectively). Exhibits potent and prolonged antivasopressor activity and indu | |||
T28653 |
S-8510 free base
SB 737552,SB-737552,S8510,SB737552,S-8510,S 8510 |
||
S-8510 is a GABA-A receptor inverse agonist. S-8510 selectively potentiated pentylenetetrazol-induced convulsion without affecting minimal electroconvulsive shock- or strychnine-induced convulsion in ddY mice. S-8510 ameliorated memory impairment induced | |||
T76221 |
Leptin (116-130)
|
||
Leptin(116-130)是一种生物活性的瘦素片段,能促进AMPA受体运输至突触并加强活动依赖性的海马突触可塑性。此外,Leptin(116-130)在抗淀粉样蛋白毒性模型中有效阻止海马突触损伤和神经元细胞死亡,显示出对研究阿尔茨海默病(AD)具有重要潜力。 | |||
T80185 |
Huwentoxin I
HWTX-I |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Huwentoxin I (HWTX-I)为一种肽毒素,针对电压门控钠通道和N型钙通道具有抑制作用。该化合物对大鼠海马神经元和蟑螂DUM神经元的钠离子通道展现出抑制能力,其IC50值分别为66.1 nM和4.80 nM。 | |||
T60911 | SSTR4 agonist 4 | ||
SSTR4 agonist 4 是一种有效的SSTR4激动剂,具有用于疼痛研究的潜力。SSTR4 激动剂在与急性和慢性相关的抗外周伤害感受和抗炎活性相关疼痛的啮齿动物模型中有效。SSTR4 在海马和新皮质、记忆和学习区域以及阿尔茨海默病病理学中的表达水平相对较高。 | |||
T70063 |
GYKI 52466 HCl
|
||
GYKI 52466 is an allosteric AMPA receptor antagonist. It selectively inhibits AMPA-induced inward currents (IC50 = 7.5 µM) over NMDA- or GABA-induced inward currents in primary rat hippocampal neurons at 50 µM but also inhibits kainate-induced inward currents in the same cells (IC50 = 11 µM).2 GYKI 52466 (10 µM) reduces the amplitude of spontaneous excitatory postsynaptic currents (EPSCs) in the same cells. It increases the latency to seizure onset and reduces mortality in a rat model of general... | |||
T35663 |
Cortistatin-29 (rat) (trifluoroacetate salt)
|
||
Cortistatin-29 is a neuropeptide that is structurally similar to somatostatin-28. It is produced by cleavage of preprocortistatin to procortistatin, which is cleaved at dibasic amino acids to form cortistatin-29 and cortistatin-14 as well as other partial cleavage products. Cortistatin mRNA is expressed in the human brain and in interneurons of the rat hippocampus and cerebral cortex. Cortistatin-29 binds to somatostatin (SST) receptors with IC50 values of 2.8, 7.1, 0.2, 3, and 13.7 nM for SST1-... | |||
T76493 |
(Glu2)-TRH
|
||
(Glu2)-TRH 是一种代谢稳定的 Thyrotropin-releasing hormone(TRH) 类似物,是小鼠大脑中 TRH 胆碱能作用的负调节剂。(Glu2)-TRH 显着减弱 TRH 诱导的海马细胞外乙酰胆碱释放。(Glu2)-TRH 不被甲状腺解放酶代谢。(Glu2)-TRH 在中枢神经系统中表现出神经保护、抗抑郁、抗惊厥作用。 | |||
T73511 |
SZM679
|
RIP kinase | Apoptosis; NF-κB |
SZM679是一种口服有效的选择性RIPK1抑制剂,其对RIPK1的Kd值为8.6 nM,而对RIPK3的Kd值则大于5000 nM。该化合物能够逆转肿瘤坏死因子诱导的全身炎症反应,并在海马和皮质中降低Tau蛋白的过度磷酸化、神经炎症以及RIPK1磷酸化水平。SZM679可用于阿尔茨海默病(AD)的研究。 | |||
T61930 | Yhhu-3792 | ||
Yhhu-3792 激活 Notch 信号通路并促进 Hes3 和 Hes5 的表达。Yhhu-3792 增强神经干细胞 (NSC) 的自我更新能力,扩大了 NSC 池并促进了小鼠海马齿状回部分 (DG) 的内源性神经形成。Yhhu-3792 可提高小鼠的情景和空间记忆能力。 Yhhu-3792 在记忆障碍相关 DG 功能障碍中具有研究潜力。 | |||
T11827 |
Pradigastat
ANJ908,LCQ908-NXA,LCQ908A,LCQ-908 |
Transferase | Metabolism |
Pradigastat (LCQ-908) 是一种具有口服活性、有效性和选择性的二酰基甘油酰基转移酶 1 (DGAT1) 抑制剂,可用于治疗便秘,可用于研究肥胖和糖尿病。 | |||
T79718 |
CaMKIIα-PHOTAC
|
CaMK | Neuroscience |
CaMKIIα-PHOTAC是一种靶向Ca2+/钙调蛋白依赖性蛋白激酶IIα(CaMKIIα)的光化学靶向嵌合体(PHOTAC)。该分子在特定波长光照射下实现靶蛋白的泛素化及通过蛋白酶体催化的降解。CaMKIIα-PHOTAC能在光照条件下显著降低小鼠海马区域的诱发LTP反应强度,减弱突触功能,并对维护亚细胞级别的树突结构域、长时程增强及记忆能力起到关键作用。 | |||
T71142 |
Tebuconazole-d9
|
||
Tebuconazole-d9 is intended for use as an internal standard for the quantification of tebuconazole by GC- or LC-MS. Tebuconazole is a triazole fungicide that is active against both seed and foliar fungi. It inhibits 14α-demethylase isolated from U. maydis and S. bicolor with IC50 values of 0.05 and 0.16 nM, respectively. It inhibits the androgenic effect of the androgen receptor agonist DHT (IC20 = 2.89 µM) and is cytotoxic (EC20 = 38.9 µM) in an MDA-kb2 assay. Tebuconazole (50 and 100 mg/kg per... | |||
T83909 |
6-hydroxy Buspirone
BMY 28674,BMS-52821 |
||
6-hydroxy Buspirone是抗焦虑化合物buspirone的活性代谢产物,通过细胞色素P450(CYP)亚型CYP3A4从buspirone转化而来。该化合物在大鼠海马和背侧缝核的5-羟色胺(5-HT)受体亚型5-HT1A上具有亲和力(EC50s分别为4和1 µM),并作为多巴胺D2、D3、D4受体拮抗剂(IC50s分别为3.1、4.9、和0.85 µM)。同时,它还以浓度依赖性方式抑制表达人类转运体的S2近端小管细胞中的有机阳离子转运体1(OCT1)、OCT2和OCT3。 | |||
T64672 |
Colivelin TFA
|
||
Colivelin (sequence SALLRSIPAPAGASRLLLLTGEIDLP) is composed of activity-dependent neurotrophic factor (ADNF) C-terminally fused to AGA-(C8R)HNG17, a potent HN derivative. It works as a neuroprotective peptide and activator of STAT3. Colivelin-induced neuroprotection has been confirmed to occur via two neuroprotective pathways: one mediated by Ca2+/calmodulin-dependent protein kinase IV, triggered by ADNF, and one mediated by signal transducer and activator of transcription 3, triggered by HN. Co... | |||
T37718 |
Galanin (rat, mouse) (trifluoroacetate salt)
GAL (rat, mouse),Galanin (rat, mouse) (trifluoroacetate salt) |
||
Galanin is a neuropeptide with diverse biological activities. [1][2][3][4][5] It binds to rat galanin (GAL) receptor subtypes GAL1-3 (IC50s = 0.339, 1.35, and 3.31 nM, respectively) and human GAL1-3 (IC50s = 0.288, 1.62, and 12.3 nM, respectively). [1] Galanin binds to and inhibits contraction of guinea pig gastric smooth muscle cells induced by carbachol . [2] In vivo, Galanin (6 nmol, i.c.v.) increases feeding behavior in rats and increases latency to hindpaw withdrawal in response to heat and... | |||
T36947 |
Pyrithiamine (hydrobromide)
|
||
Pyrithiamine is the pyridine analog of thiamine that prevents growth of organisms that require intact thiamine. [1] It inhibits the growth of bacterial and fungal species at a pyrithiamine:thiamine ratio of 10:1 in growth media and induces symptoms of thiamine deficiency in mice at a dietary ratio of 3:1. These effects are reversible with addition of sufficient thiamine in all species. Pyrithiamine inhibits the formation of cocarboxylase from thiamine in chicken blood in a dose-dependent manner.... | |||
T38145 | Eltoprazine | ||
Eltoprazine(DU28853) is a serenic or antiaggressive agent which as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor.IC50 value:Target: 5-HT1A/1B agonist; 5-HT2C antagonistin vitro: The binding of [3H]eltoprazine to whole tissue sections was saturable and revealed an apparent dissociation constant (Kd) of 11 nM. Specific [3H]eltoprazine binding was completely displaced by 5-HT; conversely, unlabelled eltoprazine reduced [3H]5-HT binding to the levels of no... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3767 |
Polygalacic acid
Virgaureagenin G,毛果一枝黄花皂苷元G,远志酸 |
MMP; AChR; AChE | Neuroscience; Proteases/Proteasome |
Polygalacic acid (Virgaureagenin G) 是一种从远志 Polygala tenuifolia Willd 根中分离出来的三萜,可抑制 MMP 表达。它对认知障碍有显著的神经保护作用,PA 通过抑制乙酰胆碱酯酶活性,增加胆碱乙酰转移酶活性,提高海马和额皮质中的乙酰胆碱水平来提高胆碱能系统反应性。 它可以用于骨关节炎相关研究。 | |||
T6S2227 |
Spinosin
斯皮诺素,Flavoayamenin |
Others | Others |
Spinosin (Flavoayamenin) 是一种具有神经保护作用的 C-糖苷类黄酮,从 Zizyphus jujube 种子分离得到,能够激活 Nrf2/HO-1 通路,并抑制 Aβ1-42的产生和聚合。 | |||
T4956 |
Tetrahydroxystilbene-2-O-β-D-glucoside
tetrahydroxyl diphenylethylene-2-o-gluco,何首乌苷,EH-201 |
Others | Others |
Tetrahydroxystilbene-2-O-β-D-glucoside (EH-201) 是一种低分子量的促红细胞生成素诱导剂。 | |||
T3779 |
Crocin II
Crocin 2,西红花苷II,Crocetin gentiobiosylglucosyl ester,藏红花,Tricrocin,Crocin B |
Caspase; COX; NO Synthase | Apoptosis; Immunology/Inflammation; Neuroscience; Proteases/Proteasome |
Crocin II (Crocetin gentiobiosylglucosyl ester) 是从栀子果实中分离出来的一种天然产物,具有抗氧化、抗癌和抗抑郁活性。它抑制 iNOS 和 COX-2的蛋白质和 m-RNA 的表达,还抑制NO 产生,IC50值为 31.1 μM。 |