57
21
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T39703 |
ATRA-biotin
ATRA-biotin,Biotin-ATRA-conjugate |
||
ATRA-biotin is a biotin-conjugated form of all-trans retinoic acid (ATRA). It is utilized for the purpose of tracking ATRA within cells or specific tissues. | |||
T35629 |
ATRA-BA Hybrid
|
||
ATRA-BA hybrid is a mutual prodrug form of all-transretinoic acid and butyric acid .1ATRA-BA hybrid is cleaved to release ATRA and BA in isolated mouse plasma. It inhibits the growth of MDA-MB-231 breast and PC3 prostate cancer cells with GI50values of 0.01 and 1.02 μM, respectively. ATRA-BA (20 μM) has 15-fold greater antiproliferative activity in PC3 cells compared to an equimolar concentration of ATRA and BA. 1.Gediya, L.K., Khandelwal, A., Patel, J., et al.Design, synthesis, and evaluation o... | |||
T17733 |
ATRA-hydroxyimino
CRABP-II ligand 1 |
Others | Others |
ATRA-hydroxyimino, also known as CRABP-II ligand 1, is a chemical compound derived from Retinoic acid (ATRA). This compound binds to the cIAP1 ligand, specifically Bestatin, through a linker, resulting in the formation of a complex called SNIPER. The purpose of this complex is to degrade CRABP-II within IMR-32 cells[1]. | |||
T67921 |
Retinoic acid-d5
all-trans-Retinoic acid-d5,Isotretinoin-d5,Vitamin A acid-d5,Accutane-d5,ATRA-d5 |
Retinoid Receptor | Metabolism |
Retinoic acid-d5 (Vitamin A acid-d5)是视黄酸的氘标记形式。视黄酸是一种天然的RAR 核受体激动剂, 对 RARα/β/γ 的 IC50 为 14 nM,与 PPARβ/δ 结合的Kd 为 17 nM。视黄酸是维生素a 的代谢物,在细胞生长、分化和器官发育中起着重要作用。视黄酸通过激活视黄酸受体α作为转录因子Nrf2的抑制剂来发挥作用。 | |||
T23154 |
Piclamilast
RPR 73401,RP 73401,吡拉米司特 |
PDE | Metabolism |
Piclamilast (RP 73401) 是一种有效的磷酸二酯酶 4(PDE4)的抑制剂,对猪主动脉和可溶性嗜酸性粒细胞中的 IC50值分别为 16 nM 和 2 nM。 | |||
T5626 |
Atrazine
Aktikon,Chromozin,Gesaprim,莠去津,Oleogesaprim,阿特拉津 |
Others | Others |
Atrazine (Oleogesaprim) 能够抑制光磷酸化,但通不会在短期内导致致命性或永久性细胞损伤,常用于控制一年生阔叶杂草。 | |||
T17265 |
Ximelagatran
EXANTA,H 376-95,H37695,希美加群,H 376/95,H-37695,H 37695 |
Thrombin | Proteases/Proteasome |
Ximelagatran (H 376-95) 是一种口服活性凝血酶抑制剂,可选择性的、竞争性的抑制游离和凝块结合的凝血酶。它是一种抗凝药物,具有快速起效的抗凝作用,可预测的,剂量依赖性的药代动力学和药效学。 | |||
T7221 |
Satraplatin
BMS182751,JM216,顺式-二氯-反式-二乙酸-氨-环己胺合铂,BMY45594 |
DNA Alkylator/Crosslinker; DNA Alkylation | DNA Damage/DNA Repair |
Satraplatin (BMS182751) 是一种烷化剂 ,是一种口服的抗肿瘤铂 (IV) 复合物,具有广泛的抗肿瘤效果。 | |||
T10951 |
Dabigatran ethyl ester hydrochloride
N-[[2-[[[4-(氨基亚氨甲基)苯基]氨基]甲基]-1-甲基-1H-苯并咪唑-5-基]羰基]-N-(2-吡啶基)-BETA-丙氨酸乙酯盐酸盐 |
Others; Thrombin | Others; Proteases/Proteasome |
Dabigatran ethyl ester hydrochloride 是一种核糖基二氢烟酰胺脱氢酶抑制剂,IC50=0.8 μM,也是一种凝血酶的抑制剂。 | |||
T1459 |
Cisatracurium besylate
顺苯磺酸阿曲库铵,顺苯磺阿曲库铵,51W89 |
Adrenergic Receptor; AChR; Autophagy | Autophagy; GPCR/G Protein; Neuroscience |
Cisatracurium besylate (51W89) 是一种用于静脉内给药的非去极化骨骼肌松弛剂。 | |||
T5133 |
Dabigatran Etexilate Mesylate
甲磺酸达比加群酯,BIBR 1048MS,Dabigatran etexilate methanesulfonate |
Thrombin | Proteases/Proteasome |
Dabigatran Etexilate Mesylate (BIBR 1048MS) 是一种口服具有活性的 Dabigatran 前药,具有抗凝作用,能够预防心房颤动引起的静脉血栓栓塞和中风。 | |||
T6397 |
Atracurium besylate
Tracrium,51W89,BW-33A,苯磺酸阿曲库铵 |
AChR | Neuroscience |
Atracurium besylate (51W89) 是一种神经肌肉阻断剂,ED95为0.2 mg/kg。 | |||
T31806 |
Flovagatran
TGN 255 |
Thrombin | Proteases/Proteasome |
Flovagatran (TGN 255) 是一种具有口服活性和有效性的凝血酶和肠外直接因子 II 抑制剂。Flovagatran 可用于研究静脉血栓栓塞。 | |||
T6295 |
Dabigatran
BIBR 953,BIBR 953ZW,达比加群 |
Thrombin | Proteases/Proteasome |
Dabigatran (BIBR 953ZW) 是一种口服抗凝剂,是一种可逆的,竞争性的直接凝血酶 (thrombin) 抑制剂,Ki=4.5 nM。它也抑制凝血酶诱导的血小板聚集 (IC50=10 nM)。 | |||
T30191L |
Atecegatran TFA
Atecegatran TFA(917904-13-3 Free base),AR-H067637 TFA |
Others | Others |
Atecegatran TFA 常被当作一种抗凝血剂,可用来治疗心血管疾病。 | |||
T5642 |
Tegatrabetan
BC2059 |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
Tegatrabetan (BC2059) 是β-Catenin 拮抗剂,能够破坏 β-catenin 与转导素 β 样蛋白 1 (TBL1) 结合。 | |||
T16098 |
Islatravir
MK-8591 |
HIV Protease; Reverse Transcriptase | Microbiology/Virology; Proteases/Proteasome |
Islatravir (MK-8591) 是一种核苷逆转录酶抑制剂,是抗HIV-1药物,对 HIV-1 (WT),HIV-1 (M184V),HIV-1 (MDR) 的EC50值分别为 0.068 nM,3.1 nM 和 0.15 nM。 | |||
T25364L |
Efegatran sulfate
LY294468 sulfate,GYKI-14766 sulfate,LY 294468 sulfate,LY-294468 sulfate |
Thrombin | Proteases/Proteasome |
Efegatran sulfate (LY294468 sulfate) 是一种有效的凝血酶抑制剂,可用于治疗血栓类疾病。 | |||
T0389 |
Dabigatran etexilate
达比加群酯,BIBR 1048 |
Thrombin | Proteases/Proteasome |
Dabigatran etexilate (BIBR 1048) 是一种 Dabigatran 前药,具有口服活性。它具有抗凝作用,能够预防心房颤动引起的静脉血栓栓塞和中风。 | |||
TQ0259 |
Atrasentan
A-147627,(+)-A 127722,阿曲生坦,ABT-627 |
Endothelin Receptor | GPCR/G Protein |
Atrasentan (ABT-627) 是内皮素受体 (endothelin receptor) 拮抗剂,能够抑制 ETA 的活性(IC50:0.0551 nM)。 | |||
TQ0270 |
Atrasentan hydrochloride
(+)-A 127722 hydrochloride,ABT-627 hydrochloride,盐酸阿曲生坦,A-147627 hydrochloride |
Endothelin Receptor | GPCR/G Protein |
Atrasentan hydrochloride (ABT-627 hydrochloride) 是内皮素 A 受体选择性拮抗剂,抑制内皮素 A 受体活性的IC50为 0.0551 nM。 | |||
T11994 |
Melagatran
|
Thrombin | Proteases/Proteasome |
Melagatran 是一种直接作用且可口服的凝血酶抑制剂。Melagatran 专一性抑制凝血酶,但不影响凝血级联中的其他酶或纤溶酶。Melagatran不依赖内源性辅因子发挥其抗凝血酶效果,可缓解内毒素血症的有害影响。因此,Melagatran作为预防动脉闭塞的策略显示出前景。 | |||
T12015 |
Methyl homoveratrate
|
Others | Others |
Methyl homoveratrate 是血浆、尿液和粪便提取物中 McN5691 的代谢物,是电压依赖性钙通道阻滞剂。 | |||
T70198 | Atrasentan sodium | ||
Atrasentan, also known as ABT-627, is a orally available ETA receptor antagonist with potential antineoplastic activity. As a selective antagonist of the endothelin-A (ETA) receptor, atrasentan binds selectively to the ETA receptor, which may result in inhibition of endothelin-induced angiogenesis and tumor cell proliferation. | |||
T10950 |
Dabigatran D4 hydrochloride
BIBR-953 D4 hydrochloride |
Others | Others |
Dabigatran D4 hydrochloride is deuterium-labeled dabigatran, which is a reversible and selective direct thrombin inhibitor (DTI) with a Ki value of 4.5 nM. | |||
T76712 | Satralizumab | ||
Satralizumab为一种人源化单克隆抗体,有效抑制白细胞介素-6(IL-6)。此抗体能防止dTAA在褐家鼠中的形成与发展,并可应用于视神经脊髓炎(NMOSD)及降胸主动脉动脉瘤(dTAA)的研究。 | |||
T78319 |
Gatralimab
GZ-402668 |
||
Gatralimab(GZ-402668)为IgG1类抗CD52单克隆抗体。 | |||
T36469 |
Atrazine Mercapturate
|
||
Atrazine mercapturate is a major, glutathione-derived metabolite of atrazine , an herbicide that is effective in controlling a broad range of weeds. Atrazine has been reported to cause cancer in certain laboratory animals, have diverse effects on the reproductive system in animals and humans, and disrupt the normal function of the endocrine system. Atrazine mercapturate is readily measured in urine samples. | |||
T69507 |
Silatrane
|
||
Silatrane is a reversible cholinesterase inhibitor and anti-tumor agent. | |||
T39310 |
Sofigatran
索非加群,MCC-977 |
||
Sofigatran (MCC-977) is an orally active inhibitor of factor IIa, also known as thrombin, and functions as an anticoagulant. It is primarily utilized in cardiovascular disease research. | |||
T25364 |
Efegatran
LY 294468,LY294468,LY-294468 |
||
Efegatran is a hematologic agent and platelet aggregation inhibitor. | |||
T24761 |
Satranidazole
GO 10213,C 10213 Go |
||
Satranidazole is an anti-bacterial. It is used to treat periodontitis. | |||
T16273 |
Napsagatran hydrate
Ro 46-6240/010 hydrate,Ro 46-6240 hydrate |
Others | Others |
Napsagatran hydrate is a novel and specific inhibitor of thrombin. | |||
T82717 |
cis-Indatraline hydrochloride
cis-Lu 19-005 |
||
cis-Indatraline (cis-Lu 19-005) hydrochloride 是一款用于神经退行性疾病研究的活性化合物。 | |||
T123832 |
Cynatratoside B
|
||
Cynatratoside B 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T123832,CAS号为 97399-97-8。 | |||
T68488 |
Indatraline
|
||
Indatraline is a nonselective monoamine transporter inhibitor. | |||
T27336 |
Flovagatran sodium
TGN255,TGN-255,TGN 255 |
||
Flovagatran sodium, a thrombin inhibitor, is used potentially for the treatment of thrombosis. | |||
T69456 | Melagatran monohydrate | ||
Melagatran monohydrate is a thrombin inhibitor. Melagatran prevents tissue factor expression in human platelet-monocyte heterotypic complexes. Melagatran reduces advanced atherosclerotic lesion size and may promote plaque stability in apolipoprotein E-deficient mice. | |||
T70233 | Efegatran HCl | ||
Efegatran, also known as GYKI-14166, RGH-2958 and LY294468, a thrombin inhibitor which is being developed by IVAX for the potential treatment of thromboembolic disorders. | |||
T31915 |
Gatratet
Carbobenzoxy-trp-met-asp-phe-amide |
||
Gatratet is a tetrapeptide. | |||
T30191 |
Atecegatran
metabolite of AZD0837,atecegatran metoxil |
||
Atecegatran 常被当作一种抗凝血剂属于,可用来治疗心血管疾病。 | |||
T11659 |
Inogatran
伊诺加群,H-314-27 |
Others | Others |
Inogatran is a synthetic thrombin inhibitor, developed for the possible treatment and prophylaxis of venous and arterial thrombotic diseases. | |||
T75283 | Atracurium | ||
Atracurium (BW-33A free acid)为高效的竞争性非去极化神经肌肉阻滞剂,兼具AChR受体拮抗作用。该化合物能够诱导支气管收缩及实现神经肌肉阻滞,并促进星形胶质细胞分化[5]。 | |||
T34535 |
Satratoxin G
Satratoxin-G |
||
Satratoxin G is a trichothecene mycotoxin of Stachybotrys chartarum and has been shown to selectively induces apoptosis in olfactory sensory neurons (OSNs) of the nose and brain. | |||
T22867 |
Indatraline hydrochloride
|
Others | Others |
Inhibits transporters for 5-HT (SERT), dopamine (DAT) and noradrenalin (NET) | |||
T20888 | Atraton | ||
Atraton is an Agricultural Chemical. | |||
T83873 |
Dabigatran Acyl-β-D-Glucuronide TFA
Dabigatran β-1-O-Acyl Glucuronide |
||
Dabigatran acyl-β-D-glucuronide是凝血酶抑制剂dabigatran的一种活性代谢产物,主要通过UDP-葡萄糖醛酸转移酶(UGT)的UGT2B15亚型形成。在人体去除血小板的贫血浆中,Dabigatran acyl-β-D-glucuronide (0.46 µM) 能增加活化部分凝血活酶时间(aPTT)。 | |||
T30192 |
Atecegatran metoxil
Atecegatran fexenetil,AZD-0837,AZD 0837,AZD0837 |
||
Atecegatran Metoxil (Atecegatran Fexenetil ,AZD0837) is an oral direct thrombin inhibitor,which currently in clinical development for the prevention of stroke and systemic embolic events in patients with atrial fibrillation. AZD0837 is a selective and re | |||
T126467 |
Atractysucrose IIIa
|
||
Atractysucrose IIIa 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T126467,CAS号为 1053636-75-1。 | |||
T35939 |
Dabigatran Acyl-β-D-Glucuronide
|
||
Dabigatran acyl-β-D-glucuronide is a major active metabolite of the thrombin inhibitor dabigatran . The prodrug of dabigatran, dabigatran etexilate , is hydrolyzed by plasma esterases to form dabigatran, which is metabolized primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT2B15 to form dabigatran acyl-β-D-glucuronide. Dabigatran acyl-β-D-glucuronide increases activated partial thromboplastin time (aPTT) in isolated human platelet-poor plasma equipotently to dabigatran. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1051 |
Retinoic acid
维生素A酸,Vitamin A acid,ATRA,all-trans-Retinoic acid,Tretinoin |
Retinoid Receptor; Endogenous Metabolite; PPAR; Autophagy | Autophagy; DNA Damage/DNA Repair; Metabolism |
Retinoic acid (Tretinoin) 是维生素 A 的代谢产物,是一种视黄酸受体 RAR 的天然激动剂,抑制 RARα/β/γ (IC50=14 nM)。Retinoic acid 可以诱导细胞分化、减少细胞增殖和抑制肿瘤发生。 | |||
T5657 |
Veratraldehyde
3,4-Dimethoxybenzaldehyde,藜芦醛 |
Antifungal | Microbiology/Virology |
Veratraldehyde (3,4-Dimethoxybenzaldehyde) 是一种能够使用于香料,农业化学和制药工业中的重要化学品。 | |||
T3364 |
Veratramine
NSC17821,黎芦碱,NSC23880,藜芦胺 |
Sodium Channel | Membrane transporter/Ion channel |
Veratramine (NSC-23880) 是一种信号转导抑制剂,可作用于肿瘤。 | |||
T8170 |
Carboxyatractyloside
羧基苍术苷,Gummiferin,Carboxyatractyloside tripotassium salt |
Others | Others |
Carboxyatractyloside (Carboxyatractyloside tripotassium salt) tripotassium salt 是一种 ADP/ATP 载体蛋白 (ADP/ATP carrier) 抑制剂,抑制线粒体 ADP/ATP 的转运。它是一种具有毒性的天然产物, | |||
TN1413 |
Atranorin
荔枝素,巴美灵,荔枝素 |
Endogenous Metabolite; NO Synthase; Ras | GPCR/G Protein; Immunology/Inflammation; MAPK; Metabolism |
Atranorin 是地衣的次生代谢产物,具有显着的抗伤害、抗炎和氧化还原活性,对 H(2)O(2) 诱导的氧化应激下的细胞具有细胞保护作用。 | |||
TN3340 |
Acetylatractylodinol
Tractylodinol acetate,乙酰基仓术呋喃烃醇 |
Others | Others |
Acetylatractylodinol (Tractylodinol acetate) 是分离自Atractylodes lancea 中,具有抗氧化作用。 | |||
T5S0167 |
Atractylenolide I
白术内酯 I,白术内酯I;苍术内酯I |
IL Receptor; TNF; TLR; JAK; STAT | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Stem Cells |
Atractylenolide I 是从白术根中得到的一种倍半萜烯,具有神经保护、抗过敏、抗炎和抗癌等多种生物活性。它是一种TLR4拮抗剂,在 A375 细胞中,能够降低JAK2和STAT3的磷酸化水平。 | |||
TCS1372 |
Atraric acid
|
Phosphatase; Androgen Receptor | Endocrinology/Hormones; Metabolism |
Atraric acid 衍生物作为一种新的化学先导结构,用于作为 AR 拮抗剂的新型治疗化合物,可用于预防或治疗前列腺疾病。它以剂量依赖性方式抑制 PTP1B 活性,IC50 值为 51.5 uM,表明阿特拉酸具有治疗糖尿病的潜力。 | |||
T5S0168 |
Atractylenolide II
2-Atractylenolide,Asterolide,苍术内酯II |
Apoptosis; ERK; p38 MAPK; Akt; STAT | Apoptosis; Cytoskeletal Signaling; JAK/STAT signaling; MAPK; PI3K/Akt/mTOR signaling; Stem Cells |
Atractylenolide II (2-Atractylenolide) 是一种从白术干燥根茎分离的倍半萜类天然产物,具有抗增殖活性。 | |||
T3666 |
Atractylodin
苍术素,Atractydin |
Lipid | Metabolism |
Atractylodin (Atractydin) 是一种Atractylodes lancea 和A. chinensis 的根茎中所含精油的活性成分。它是天然杀虫剂,能够抑制Tribolium castaneum 的活性。 | |||
T3902 |
Atractylenolide III
白术内酯 III,ICodonolactone,8β-Hydroxyasterolide |
Apoptosis | Apoptosis |
Atractylenolide III (ICodonolactone) 是白术根茎主要成分,通过诱导细胞色素 c 的释放、上调 Bax 的表达和易位凋亡诱导因子,是治疗人肺癌的潜力。 | |||
T3791 |
Atractyloside A
|
AChR | Neuroscience |
Atractyloside A 是存在于一些植物中的贝壳杉类二萜糖苷,具有降血压、降血糖、抗肿瘤等活性。 | |||
T3S0156 |
Atractyloside potassium salt
Atractyloside Dipotassium Salt,苍术苷钾盐,苍术苷二钾盐 |
Others | Others |
Atractyloside potassium salt (Atractyloside Dipotassium Salt) 是一种从苍术果实中分离出得到的二萜苷类化合物,具有毒性。它能抑制大鼠心脏线粒体膜的氯离子通道。它是高效、特异性的线粒体 ADP/ATP 转运 (ADP/ATP transport) 抑制剂。 | |||
TN3304 |
8beta-Methoxyatractylenolide I
|
Others | Others |
8beta-Methoxyatractylenolide I is a natural product from Atractylodes macrocephala. | |||
TN6469 | Biatractylolide | ||
Biatractylolide has a neuroprotective effect on glutamate-induced injury in PC12 and SH-SY5Y cells through a mechanism of the PI3K-Akt-GSK3β-dependent pathways. The molecular mechanisms of inhibitory activities of biatractylolide on AChE are not only thro | |||
T82634 | Cynatratoside D | ||
Cynatratoside D为从白黎芦醇根部分离提取的一种寡糖苷。 | |||
T34536 |
Satratoxin H
Satratoxin-H |
||
Satratoxin H is an air- and food-borne mycotoxin, which has been implicated in human health damage. | |||
TN3747 |
Cynatratoside A
|
Antifection | Microbiology/Virology |
Cynatratoside A and Cynanversicoside C are therefore potential candidate drugs for use against Ichthyophthirius multifiliis. | |||
T3S0165 |
Atractylone
Atractylon,苍术酮 |
Others | Others |
Atractylone (Atractylon) 具有保肝、降血糖、抗菌、抗肿瘤、抗病毒等作用。 | |||
TN3468 | Atractylochromene | Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
Atractylochromene is an inhibitor of β-catenin dependent Wnt pathway, it may be a potential chemotherapeutic agent for the prevention and treatment of human colon cancer. | |||
T6S1315 |
Oroxylin A
千层纸素A,6-Methoxybaicalein,Baicalein 6-methyl ether |
Virus Protease; HIF/HIF Prolyl-Hydroxylase; Autophagy | Autophagy; Chromatin/Epigenetic; Metabolism; Microbiology/Virology |
Oroxylin A (Baicalein 6-methyl ether) 是一种有活性的黄酮,具有较强的抗癌作用。 |