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75

抑制剂 & 化合物

18

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T29909	ALS-I ALS1,Acid-Liable Surfactant-1,ALS 1,ALS-1
	ALS-1 is an acid-Liable surfactant.
T14336	Allitinib AST-1306,ALS 1306	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Allitinib (AST-1306) 是可口服的 EGFR 和 ErbB2不可逆抑制剂，IC50分别为 0.5 和 3 nM。它具有抗癌活性，抑制 ErbB4，IC50为 0.8 nM。
T14195	ALS-8112	Others	Others
	ALS-8112 is a inhibitor of respiratory syncytial virus (RSV) polymerase. The 5'-triphosphate form of ALS-8112 inhibits RSV polymerase (IC50: 0.02 μM).
T26602	ALS-I-41
	ALS-I-41 is a novel, potent and selective antagonist of oxytocin receptor.
TQ0034	Lumicitabine ALS-8176,ALS-008176	RSV	Microbiology/Virology
	Lumicitabine (ALS-008176) is an inhibitor of RSV polymerase.
T29970	AMG-222 AMG 222,ALS-2-0426 free base,ALS-2-0426,ALS-20426
	AMG-222 (ALS-2-0426, ALS-20426) is a DPP-4 inhibitor and may be used in the treatment of type 2 diabetes.
T19859	Nicosulfuron Milagro,Accent,Motivell,烟嘧磺隆	Others	Others
	Nicosulfuron (Milagro) 是一种磺酰脲类的选择性除草剂，常用作出苗后的除草剂，保护玉米作物免受杂草的侵害。它也能够降低乙酰乳酸合酶的活性。
T3198L	PRE-084 hydrochloride	Sigma receptor	GPCR/G Protein
	PRE-084 hydrochloride 是 σ1 的选择性激动剂在sigma 受体检测中，IC50值为44 nM。
T39924	NF-κΒ activator 2	NF-κB	NF-κB
	NF-κΒ activator 2 是口服有效的 NF-ҡB 激活剂，EC50为 1.58 μM。它通过增加 NF-κB 的表达和激活来诱导 SOD2。它具有用于研究肌萎缩性侧索硬化症的价值。
T67848	Valsartan Methyl Ester	RAAS	Endocrinology/Hormones
	Valsartan Methyl Ester 是一种强效血管紧张素II 受体拮抗剂，IC50=0.06uM。
T0498	Salsalate Disalicylic acid,Salicylsalicylic acid,Sasapyrine,NSC-49171,双水杨酸酯	Reactive Oxygen Species; COX	Immunology/Inflammation; Metabolism; Neuroscience; NF-κB
	Salsalate (Sasapyrine) 是一种有效的抗风湿药物，是一种非乙酰化水杨酸盐，可以绕过胃的吸收，也可以避免环氧合酶的抑制。它具有抗炎活性，降低血糖水平、胰岛素抵抗和细胞因子表达，可用于研究 2 型糖尿病。
TQ0277	Pralsetinib 普拉替尼,Blu667	c-RET	Apoptosis; Tyrosine Kinase/Adaptors
	Pralsetinib (Blu667) 是高效的、选择性的RET 抑制剂。它能够抑制 WT RET (IC50:0.4 nM)，RET 突变体 V804L (IC50:0.3 nM)，V804M (IC50:0.4 nM)，M918T (IC50:0.4 nM) 和 CCDC6-RET (IC50:0.4 nM) 的融合。
T39350	Sebetralstat KVD900	Others	Others
	Sebetralstat (KVD900) 是一种血浆激肽释放酶抑制剂，可用于代谢性疾病的研究。
T2318	Sacubitril/Valsartan Sacubitril mixture with Valsartan,沙库必曲/缬沙坦,Valsartan,Sacubitril,LCZ696	Apoptosis; RAAS; Neprilysin	Apoptosis; Endocrinology/Hormones; Metabolism
	Sacubitril/Valsartan (LCZ696)，以1:1摩尔比由Valsartan（一种ARB）和Sacubitril（AHU377）组成，为创新口服血管紧张素受体-脑啡肽酶（ARN）双重抑制剂，旨在治疗高血压与心力衰竭。其作用机制包括抑制炎症、氧化应激及细胞凋亡，有助于改善糖尿病心肌病。
T4615	Balsalazide sodium hydrate 巴柳氮钠水合物,Balsalazide disodium dihydrate,巴柳氮钠,Balsalazide disodium salt dihydrate,Balsalazide disodium	STAT; Interleukin	Immunology/Inflammation; JAK/STAT signaling; Stem Cells
	Balsalazide sodium hydrate (Balsalazide disodium) 可通过调节IL-6/STAT3通路起抑癌作用，可用于治疗炎症性肠病。
T7426	ALSTERPAULLONE	Apoptosis; GSK-3; CDK	Apoptosis; Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells
	Alsterpaullone 是高效的 CDK 抑制剂，是一种 ATP 竞争性的 GSK-3alpha/GSK-3beta 抑制剂，且作用的 IC50值都为 4 nM。它有用于神经退行性和增生性疾病的研究潜力，具有抗肿瘤活性，诱导白血病细胞凋亡。
T17216	Valspodar PSC 833	P-gp	Membrane transporter/Ion channel; Neuroscience
	Valspodar (PSC 833) 是一种特异性的 P-糖蛋白抑制剂和MDR调节剂，常被用作化学增敏剂，可用于研究晚期上皮卵巢癌。
T14358	Avoralstat BCX4161	Others	Others
	Avoralstat (BCX4161) 是血浆激肽释放酶(PKK)抑制剂，具有口服活性，可用于遗传性血管性水肿的研究。
T6716	Valsartan Diovan,缬沙坦,Tareg,CGP 48933	RAAS	Endocrinology/Hormones
	Valsartan (CGP 48933) 是一种血管紧张素 II 受体拮抗剂，有用于高血压和心力衰竭的研究潜力。
T13283	Valsartan Ethyl Ester	Others	Others
	Valsartan Ethyl Ester is an impurity of Valsartan. Valsartan is an antagonist of the angiotensin II receptor and for the treatment of high blood pressure and heart failure.
T4571	Balsalazide 巴柳氮,Balsalazido	Lipoxygenase; STAT; Interleukin	Immunology/Inflammation; JAK/STAT signaling; Metabolism; Stem Cells
	Balsalazide (Balsalazido) 可通过调节IL-6/STAT3通路起抑癌作用，可用于治疗炎症性肠病。
T31379	deOxy-DALSiR deOxy DALSiR
	deOxy-DALSiR is a selective and sensitive near-infrared fluorescent probe for visualization of endogenous nitric oxide in living cells and animals.
T124585	rac Salsolinol, Hydrobromide
	rac Salsolinol, Hydrobromide 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T124585，CAS号为 59709-57-8。
T23417	Talsupram hydrochloride	Others	Others
	noradrenalin re-uptake inhibitor
T123974	Salsoloside C
	Salsoloside C 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T123974，CAS号为 89827-13-4。
T81560	Palsucibep pegol
	Palsucibep pegol为工程化人类lipocalin-2结合蛋白，与hepcidin发生结合。
T68890	Desvaleryl Valsartan
	Desvaleryl valsartan is a potential impurity found in commercial preparations of the angiotensin II type 1 (AT1) receptor antagonist valsartan. It is a degradation product formed under acidic conditions.
T35869	Berotralstat
	Berotralstat (BCX7353) is a second-generation, synthetic, and orally active plasma kallikrein inhibitor with low toxicity. It is highly specific and effectively used in the research of hereditary angioedema (HAE) attacks. Berotralstat functions by inhibiting the enzymatic activity of plasma kallikrein, which is responsible for the release of bradykinin. This blocking mechanism targets the major biologic peptide involved in the promotion of swelling and pain associated with HAE attacks[1][2].
T29911L	Alstonidine acetate O-Acetylalstonidine
	Alstonidine acetate is a biochemical.
T131406	Venalstonine
	Venalstonine 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T131406。
T76917	Balstilimab
	Balstilimab (AGEN2034) 是一种针对PD-1的完全人单克隆IgG4抗体。
T78287	Alsevalimab
	Alsevalimab为针对B7-H4的人源化单克隆抗体。
T13282	Valsartan-d9 CGP-48933 D9,缬沙坦 D9	Others	Others
	Valsartan D9 is a deuterium-labeled valsartan. Valsartan is an antagonist of the angiotensin II receptor and for the treatment of high blood pressure and heart failure.
T131396	Carnegine (Pectenine, N-Methylsalsolidine)
	Carnegine (Pectenine, N-Methylsalsolidine) 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T131396。
T35725	4-hydroxy Valsartan
	4-hydroxy Valsartan is a major metabolite of the angiotensin II type 1 (AT1) receptor antagonist valsartan . It reduces platelet aggregation induced by epinephrine and collagen but not ADP in human whole blood.
T68555	Alsterpaullone, 2-Cyanoethyl
	Alsterpaullone, 2-Cyanoethyl is a selective dual inhibitor of Cdk1/cyclin B and GSK-3β.
T68829	(+/-)-Salsolinol Hydrochloride
	(+/-)-Salsolinol hydrochloride is a full Gi protein agonist of the μ-opioid receptor (μOR).
T29910	Alseroxylon Egalin
	Alseroxylon can be used to treat hypertension.
T76297	Alsactide
	Alsactide，一种ACTH激动剂七肽类似物，主要应用于中枢神经系统的研究。
TQ0277L	Pralsetinib HCl (2097132-94-8 free base) Pralsetinib HCl,Pralsetinib hydrochloride,BLU-667,BLU667,BLU 667
	Pralsetinib is a selective and next-generation RET inhibitor (IC50: 0.3-0.4 nM for WT RET, RET mutants V804L, V804M, M918T, and CCDC6-RET fusion). BLU-667 is an effective and selective inhibitor of RET mutations, fusions, and predicted resistant mutants.
T13071	Talsaclidine	Others	Others
	Talsaclidine is an agonist of muscarinic with preferential neuron-stimulating properties. Talsaclidine is a full agonist at the M1 subtype, and as a partial agonist at the M2 and M3 subtypes.
T29911	Alstonidine
	Alstonidine is a biochemical.
T70161	Berotralstat HCl
	Berotralstat HCl is a novel selective inhibitor of plasma kallikrein, blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE.
T131573	Isosalsolidine
	Isosalsolidine 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T131573。
T29912	Alstonidine acetate trihydrate Alstonidine acetyl deriv trihydrate
	Alstonidine acetate trihydrate is a biochemical.
T20564	Valsartan benzyl ester Valsartan impurity B,Valsartan related compound C
	Valsartan benzyl ester is a intermediate of Valsartan.
T63507	Feniralstat
	Feniralstat 是吡唑衍生物，是一种激肽释放酶 (kallikrein) 的有效抑制剂，能够抑制人血浆激肽释放酶 (pKal) (IC50: 6.7 nM)。Feniralstat 不抑制人 KLK1、人 FXIa 和人因子 Xlla (IC50均 >40 μM)。
T10823	trans-Pralsetinib cis-Pralsetinib,cis-BLU-667	c-RET	Apoptosis; Tyrosine Kinase/Adaptors
	trans-Pralsetinib (trans-BLU-667) is an inhibitor of rearranged during transfection (RET).
T60507	Utreloxastat
	Utreloxastat 是一种用于 α-突触核蛋白病、tau 蛋白病、渐冻症、创伤性脑损伤和缺血再灌注相关损伤等疾病研究的化合物。
T15562	Imazamox CL29926,甲氧咪草烟,(±)-Imazamox	Others	Others
	Imazamox ((±)-Imazamox) 是一种具有高选择性、高活性、安全性、广谱活性的全身性除草剂，能够抑制植物中乙酰乳酸合酶(ALS) 的产生，进而抑制植物生长并最终导致植物死亡。

化合物

Cat.No: T29909

Synonym: ALS1,Acid-Liable Surfactant-1,ALS 1,ALS-1

Cat.No: T14336

Synonym: AST-1306,ALS 1306

Target: EGFR

Cat.No: T14195

Target: Others

Cat.No: T26602

Cat.No: TQ0034

Synonym: ALS-8176,ALS-008176

Target: RSV

Cat.No: T29970

Synonym: AMG 222,ALS-2-0426 free base,ALS-2-0426,ALS-20426

Cat.No: T19859

Synonym: Milagro,Accent,Motivell,烟嘧磺隆

Target: Others

PRE-084 hydrochloride

Cat.No: T3198L

Target: Sigma receptor

NF-κΒ activator 2

Cat.No: T39924

Target: NF-κB

Valsartan Methyl Ester

Cat.No: T67848

Target: RAAS

Cat.No: T0498

Synonym: Disalicylic acid,Salicylsalicylic acid,Sasapyrine,NSC-49171,双水杨酸酯

Target: Reactive Oxygen Species, COX

Cat.No: TQ0277

Synonym: 普拉替尼,Blu667

Target: c-RET

Cat.No: T39350

Synonym: KVD900

Target: Others

Sacubitril/Valsartan

Cat.No: T2318

Synonym: Sacubitril mixture with Valsartan,沙库必曲/缬沙坦,Valsartan,Sacubitril,LCZ696

Target: Apoptosis, RAAS, Neprilysin

Balsalazide sodium hydrate

Cat.No: T4615

Synonym: 巴柳氮钠水合物,Balsalazide disodium dihydrate,巴柳氮钠,Balsalazide disodium salt dihydrate,Balsalazide disodium

Target: STAT, Interleukin

ALSTERPAULLONE

Cat.No: T7426

Target: Apoptosis, GSK-3, CDK

Cat.No: T17216

Synonym: PSC 833

Target: P-gp

Cat.No: T14358

Synonym: BCX4161

Target: Others

Cat.No: T6716

Synonym: Diovan,缬沙坦,Tareg,CGP 48933

Target: RAAS

Valsartan Ethyl Ester

Cat.No: T13283

Target: Others

Cat.No: T4571

Synonym: 巴柳氮,Balsalazido

Target: Lipoxygenase, STAT, Interleukin

Cat.No: T31379

Synonym: deOxy DALSiR

rac Salsolinol, Hydrobromide

Cat.No: T124585

Talsupram hydrochloride

Cat.No: T23417

Target: Others

Cat.No: T123974

Palsucibep pegol

Cat.No: T81560

Desvaleryl Valsartan

Cat.No: T68890

Cat.No: T35869

Alstonidine acetate

Cat.No: T29911L

Synonym: O-Acetylalstonidine

Cat.No: T131406

Cat.No: T76917

Cat.No: T78287

Cat.No: T13282

Synonym: CGP-48933 D9,缬沙坦 D9

Target: Others

Carnegine (Pectenine, N-Methylsalsolidine)

Cat.No: T131396

4-hydroxy Valsartan

Cat.No: T35725

Alsterpaullone, 2-Cyanoethyl

Cat.No: T68555

(+/-)-Salsolinol Hydrochloride

Cat.No: T68829

Cat.No: T29910

Synonym: Egalin

Cat.No: T76297

Pralsetinib HCl (2097132-94-8 free base)

Cat.No: TQ0277L

Synonym: Pralsetinib HCl,Pralsetinib hydrochloride,BLU-667,BLU667,BLU 667

Cat.No: T13071

Target: Others

Cat.No: T29911

Berotralstat HCl

Cat.No: T70161

Cat.No: T131573

Alstonidine acetate trihydrate

Cat.No: T29912

Synonym: Alstonidine acetyl deriv trihydrate

Valsartan benzyl ester

Cat.No: T20564

Synonym: Valsartan impurity B,Valsartan related compound C

Cat.No: T63507

trans-Pralsetinib

Cat.No: T10823

Synonym: cis-Pralsetinib,cis-BLU-667

Target: c-RET

Cat.No: T60507

Cat.No: T15562

Synonym: CL29926,甲氧咪草烟,(±)-Imazamox

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T2830	Betulinic acid 白桦脂酸,桦木酸,ALS-357,Lupatic acid,Betulic acid	Apoptosis; Mitophagy; NF-κB; HIV Protease; Topoisomerase; Endogenous Metabolite; Aminopeptidase; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
	Betulinic acid (ALS-357) 是从白桦树皮中分离出来的一种五环三萜类天然产物，是真核细胞拓扑异构酶 I 的抑制剂，IC50值为 5 μM，具有抗逆转录病毒、抗疟疾、抗癌和抗炎特性。
T22911	β-N-methylamino-L-alanine hydrochloride L-BMAA hydrochloride	Others	Others
	β-N-methylamino-L-alanine hydrochloride (L-BMAA hydrochloride) 是由蓝细菌产生的一种神经毒素，既有导致肌萎缩性侧索硬化症 (ALS) 以及其他可能的神经退行性疾病可能性。
TN2267	Tetrahydroalstonine	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Tetrahydroalstonine 是从 Rhazya stricta 的果实中提取出来的吲哚类生物碱，是一种具有选择性的 α2-肾上腺素受体拮抗剂。Tetrahydroalstonine 在Rauwolfia tetraphylla 中表现出抗精神病活性。
TN2112	Przewalskinic acid A	Others	Others
	Przewalskinic acid A is a rare, water-soluble, and highly biologically active ingredient found, thus far, only in the Salvia przewalskii Maxim herb.
T23305	Salsolinol-1-carboxylic acid	Others	Others
	amino acid that occurs naturally in the CNS
TN6032	Alstoyunine E
	Alstoyunine E shows selective inhibition of Cox-2 (>75%).
TN5204	Uralsaponin C	Others	Others
	Uralsaponin C shows the cytotoxic activity against the human cancer cell lines MGC-803, SW620, and SMMC-7721 with IC50 > 100 μmol/L.
TN4835	Przewalskin	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Przewalskin A and Przewalskin B showed modest anti-HIV-1 activity with EC50 = 41 and 30 microg/mL, respectively.
TN5931	Alstonic acid B
	Alstonic acid B是一种天然产物，属于夹竹桃科鸡骨常山属，其产品编号为 TN5931，CAS号为 1159579-45-9。Alstonic acid B可用作对照参考。
TN3398	Alstolenine	Others	Others
	Alstolenine是一种天然产物，属于夹竹桃科鸡骨常山属，其产品编号为 TN3398，CAS号为 85769-33-1。Alstolenine可用作对照参考。
T8429	Salsolidine hydrochloride 6,7-DIMETHOXY-1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE, 99

TN5251	Walsuralactam A	Others	Others
	Walsuralactam A in the formula I, which is used as an active ingredient, and is used for treating and preventing the tumour.
TN5937	Walsuronoid B
	Walsuronoid B shows weak antimalarial activity.
TN5205	Uralsaponin D	Others	Others
	Uralsaponin D displayed the inhibition on the growth of cancer cells with IC50 at 18.3-41.6 μmol/L, it could significantly increase the cytotoxic activity after hydrolysis.
T40576	(S)-Salsolidine
	(S)-Salsolidine, a chemical compound, functions as a weak inhibitor of monoamine oxidase (MAO), exhibiting an inhibition constant (K i ) of 63 μM. R enantiomer demonstrating a greater efficacy than (S)-Salsolidine, boasting a K i value of 26 μM compared to the S form.
TN3399	Alstonic acid A	Others	Others
	Alstonic acid A是一种天然产物，属于夹竹桃科鸡骨常山属，其产品编号为 TN3399，CAS号为 1159579-44-8。Alstonic acid A可用作对照参考。
T75527	Chrexanthomycin C
	Chrexanthomycin C 是一种具有显著生物活性的海洋天然产物，具有口服活性。Chrexanthomycin C 对 DNA (G4C2)4 G4 具有结合亲和力，Kd 值为 2.8 mM。Chrexanthomycin C 可用于肌萎缩侧索硬化症 (ALS) 等神经退行性疾病的研究。
T82822	Brassicanate A sulfoxide
	Brassicanate A sulfoxide 表现出除草效果，它能抑制植物中必需氨基酸的生物合成路径。该化合物通过结合并抑制多种酶的活性来发挥其作用，包括二羟酸脱水酶 (DHAD)、羟甲基丙酮酸双加氧酶 (HPPD)、乙酰乳酸合酶 (ALS)、PYL家族蛋白及转运抑制剂响应 1 (TIR1)。Brassicanate A sulfoxide 可以从甘蓝 (Brassica oleracea) 中提取获得。

天然产物

Cat.No: T2830

Synonym: 白桦脂酸,桦木酸,ALS-357,Lupatic acid,Betulic acid

Target: Apoptosis, Mitophagy, NF-κB, HIV Protease, Topoisomerase, Endogenous Metabolite, Aminopeptidase, Autophagy

β-N-methylamino-L-alanine hydrochloride

Cat.No: T22911

Synonym: L-BMAA hydrochloride

Target: Others

Tetrahydroalstonine

Cat.No: TN2267

Target: Adrenergic Receptor

Przewalskinic acid A

Cat.No: TN2112

Target: Others

Salsolinol-1-carboxylic acid

Cat.No: T23305

Target: Others

Alstoyunine E

Cat.No: TN6032

Cat.No: TN5204

Target: Others

Cat.No: TN4835

Target: HIV Protease

Alstonic acid B

Cat.No: TN5931

Cat.No: TN3398

Target: Others

Salsolidine hydrochloride

Cat.No: T8429

Synonym: 6,7-DIMETHOXY-1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE, 99

Walsuralactam A

Cat.No: TN5251

Target: Others

Cat.No: TN5937

Cat.No: TN5205

Target: Others

(S)-Salsolidine

Cat.No: T40576

Alstonic acid A

Cat.No: TN3399

Target: Others

Chrexanthomycin C

Cat.No: T75527

Brassicanate A sulfoxide

Cat.No: T82822

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