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Valsartan-d9

产品编号 T13282 CAS 1089736-73-1

别名: CGP-48933 D9, 缬沙坦 D9

Valsartan D9 is a deuterium-labeled valsartan. Valsartan is an antagonist of the angiotensin II receptor and for the treatment of high blood pressure and heart failure.

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Valsartan-d9, CAS 1089736-73-1

规格	价格/CNY		货期	数量
1 mg	￥ 6,370		35日内发货

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Valsartan-d9 的其他形式现货产品:

Sacubitril/Valsartan Valsartan

其他形式的 Valsartan-d9:

Sacubitril/Valsartan
现货
Valsartan
现货

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生物活性

化学信息

存储 & 溶解度

参考文献

产品描述	Valsartan D9 is a deuterium-labeled valsartan. Valsartan is an antagonist of the angiotensin II receptor and for the treatment of high blood pressure and heart failure.
体外活性	In ageing aorta endothelial cells, Valsartan is a synthetic antagonist of non-peptide angiotensin II type 1 receptor that dilates blood vessels and reduces blood pressure by blocking the action of angiotensin. Valsartan significantly decreases the expression of AT1R [1].The pretreatment of valsartan can inhibit TLR2 signaling and proinflammatory cytokines. The expression of AGTR1 was up-regulated after alcohol exposure and was blocked by valsartan pretreatment[2].
体内活性	In rats after MI. Heart function, Valsartan significantly attenuates the expression of TGF-β/Smad, Hif-1α and fibrosis-related protein , infarcted size, wall thickness as well as myocardial vascularization of ischaemic hearts are also significantly improved by valsartan compared with saline and hydralazine[3]. Valsartan partially reverses the effects of high-salt diet on hypertension, cardiac injuries such as fibrosis and inflammatory cell infiltration, and inhibition of aquaporin 1 and angiogenic factors; valsartan alone does not exert such effects[4]. Valsartan is an effective antidepressant/antianxiety reagent and can promote the hippocampal neurogenesis and expression of BDNF.Long-term use of valsartan (5-40 mg/kg/d, oral) increases the time spent in OFT field centers and the latency to eating in NSF, reduces the fixed time of TST and FST, and increases the preference for sucrose SPT[5].

别名	CGP-48933 D9, 缬沙坦 D9
分子量	444.57
分子式	C24H29N5O3
CAS No.	1089736-73-1

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

计算器

摩尔浓度计算器

稀释计算器

配液计算器

分子量计算器

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参考文献

1. Shan H, et al. Valsartan ameliorates ageing-induced aorta degeneration via angiotensin II type 1 receptor-mediated ERK activity. J Cell Mol Med. 2014 Jun;18(6):1071-80. 2. Wang Y, et al. Valsartan blocked alcohol-induced, Toll-like receptor 2 signaling-mediated inflammation in human vascular endothelial cells. Alcohol Clin Exp Res. 2014 Oct;38(10):2529-40. 3. Sui X, et al. Novel mechanism of cardiac protection by valsartan: synergetic roles of TGF-β1 and HIF-1α in Ang II-mediated fibrosis after myocardial infarction. J Cell Mol Med. 2015 Aug;19(8):1773-82. 4. Jiang Y, et al. Cardioprotective effect of valsartan in mice with short-term high-salt diet by regulating cardiac aquaporin 1 and angiogenic factor expression. Cardiovasc Pathol. 2015 Jul-Aug;24(4):224-9. 5. Ping G, et al. Valsartan reverses depressive/anxiety-like behavior and induces hippocampal neurogenesis and expression of BDNF protein in unpredictable chronic mild stress mice. Pharmacol Biochem Behav. 2014 Sep;124:5-12.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

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第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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