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93

抑制剂 & 化合物

12

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T22774L	eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species]（TFA)	Others	Others
	eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species](TFA) 是延伸因子 1 亚基。真核翻译延伸因子 1 alpha 1 (EEF1A1) 编码延伸因子 alpha 亚基的同种型- 1 复合物，负责将氨酰 tRNA 酶促递送至核糖体。这种亚型（α 1）在脑、胎盘、肺、肝、肾和胰腺中表达，另一种亚型（α 2）在脑、心脏和骨骼肌中表达。这种亚型在 66% 的 Felty 综合征患者中被鉴定为自身抗原。已发现该基因在许多染色体上具有多个拷贝，其中一些（如果不是全部）代表不同的假基因。
T50099	HIF-2α-IN-4	Others; HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism; Others
	HIF-2a translation inhibitor 是一种有效的HIF-2α翻译抑制剂，IC50=5 μM，能够抑制组成型和缺氧诱导的 HIF-2α 蛋白表达。其中 HIF-2α-IN-4 将 5'UTR 铁响应元件与氧传感联系起来。
TP2247	eukaryotic translation initiation factor 3	Others	Others
	Eukaryotic initiation factors (eIF) are proteins involved in the initiation phase of eukaryotic translation. Eukaryotic translation initiation factor 3 binds to the ribosome subunit-mRNA complex. It has been implicated in preventing the large ribosomal subunit from binding the small subunit before it is ready to commence elongation.
T22774	eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species]	Others	Others
	eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed
T5331	KKL-35	Antibacterial	Microbiology/Virology
	KKL-35 是一种具有广谱抗生素活性的反式翻译抑制剂，IC50值为 0.9 µM。
T3265	Azathramycin Desmethyl Azithromycin,阿奇霉素 A,6-Demethylazithromycin,去甲基阿奇霉素,Azaerythromycin A,Azaerythromycin	Antibacterial; Antibiotic	Microbiology/Virology
	Azathramycin (Desmethyl Azithromycin) 是一种可靶向核糖体的抗生素。
T22592	ATPγS tetralithium salt ATP-gamma-S tetralithium salt	PERK	Apoptosis
	ATPγS tetralithium salt 是真核生物翻译起始因子 eIF4A 的核苷酸水解和RNA解链活性的底物，与 p97 突变体和朊病毒相关。
T14886	Cbz-B3A	mTOR	PI3K/Akt/mTOR signaling
	Cbz-B3A 是一种具有现在性的 mTORC1 信号转导抑制剂，抑制 eIF4E 结合蛋白 1 （4EBP1）的磷酸化并阻断 68% 的翻译。
T11511	Guanosine-5'-triphosphate disodium salt 5'-GTP disodium salt	Others; Endogenous Metabolite	Metabolism; Others
	Guanosine-5'-triphosphate disodium salt (5'-GTP disodium salt) 是肌原性细胞分化的增强剂，也是翻译和其他重要细胞过程的能量来源。
T13767	MBX-4132	Others; Antibacterial	Microbiology/Virology; Others
	MBX-4132 通过与细菌核糖体结合来抑制反式翻译，是一种恶二唑类物质。
T3147	Pyrrolidinedithiocarbamate ammonium PDTC,Pyrrolidinedithiocarbamate,吡咯烷二硫代氨基甲酸铵,APDC,1-Pyrrolidinedithiocarboxylic acid ammonium salt,Ammonium pyrrolidinedithiocarbamate,吡咯烷二硫代甲酸铵	NF-κB	NF-κB
	Pyrrolidinedithiocarbamate ammonium (1-Pyrrolidinedithiocarboxylic acid ammonium salt) 是一种选择性的、能透过血脑屏障的NF-κB 抑制剂。
T4058	R-IMPP	Others; Serine/threonin kinase	Cell Cycle/Checkpoint; Metabolism; Others
	R-IMPP 是抗 PCSK9分泌的药物 (IC50=4.8 μM)，靶向作用于 80S 核糖体，抑制 PCSK9 蛋白的翻译。
T28543	RK-9123016 RK9123016,RK 9123016	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	RK-9123016是一种SIRT2抑制剂。RK-9123016增加真核翻译起始因子5A（eIF5A）（SIRT2的生理底物）的乙酰化水平，降低人乳腺癌细胞的细胞活力，同时降低c-Myc 表达。
T9980	AVJ16	IGF-1R	Tyrosine Kinase/Adaptors
	AVJ16作为胰岛素生长因子2 mRNA 结合蛋白家族的成员，可与某些基因的mRNA 结合来调节蛋白质翻译。
T16702	QL47	Virus Protease; BTK	Angiogenesis; Microbiology/Virology; Tyrosine Kinase/Adaptors
	QL47 是一种宿主靶向的小分子抗病毒剂，具有抗病毒活性，对登革热病毒和其他 RNA 病毒有抑制作用。QL47 可作为病毒翻译的抑制抑制剂和 BTK 的共价抑制剂，可用于研究淋巴瘤。
T8404	Kasugamycin hydrochloride hydrate Ksg (hydrochloride hydrate),春雷霉素盐酸盐一水合物	Antibacterial; Antibiotic	Microbiology/Virology
	Kasugamycin hydrochloride hydrate (Ksg (hydrochloride hydrate)) 是一种能结合 30s 和 70s 核糖体，但不能结合 50s 亚基的抗生素。它模拟 mRNA 核苷酸破坏 tRNA 结合并抑制典型翻译起始。
T3052	Sancycline Bonomycin,Norcycline,Sancyclinum,山环素,6-Demethyl-6-deoxytetracycline	Antibacterial	Microbiology/Virology
	Sancycline (Bonomycin) 是半合成四环素，通过可逆地结合 30S 核糖体亚基并通过阻断氨酰-tRNA 进入核糖体 A 位点来抑制蛋白质翻译。
T4288	hVEGF-IN-1	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	hVEGF-IN-1 是一种喹唑啉衍生物，可以特异性结合内部核糖体进入位点 A 中富含 G 的序列，并会使 G-四链体结构不稳定。在 SPR 实验中，它与 IRES-A (WT) 结合的Kd 值为 0.928 μM。它能够抑制VEGF-A 蛋白表达，阻止肿瘤细胞迁移，抑制肿瘤生长。
T19459	N1-Methylpseudouridine N1-甲基-假尿苷,1-Methylpseudouridine	Others	Others
	N1-Methylpseudouridine (1-Methylpseudouridine) 是一种甲基假尿苷，翻译性能比 5 mC 和 5 mC/N1-Methylpseudouridine 高。通过提高核糖体密度，mRNA 中的 N1-Methylpseudouridine 以 eIF2α 依赖性和独立机制增强翻译。
T16491	PF-06446846 hydrochloride	Others	Others
	PF-06446846 hydrochloride 是一种口服活性高、高选择性PCSK9(前蛋白转化酶枯草杆菌蛋白酶/kexin 9 型)翻译抑制剂。它通过在密码子34附近诱导核糖体暂停来抑制PCSK9。
T61334	DMA-135 hydrochloride DMA-135 HCl	Virus Protease	Microbiology/Virology
	DMA-135 hydrochloride (DMA-135 HCl) 靶向 RNA 的抗病毒活性化合物，抑制肠道病毒 71 型 (EV71)IRES依赖的翻译和复制。DMA-135 hydrochloride 可用于研究肠道病毒感染。
T11372	GC7 Sulfate	Autophagy	Autophagy
	GC7 Sulfate 是 deoxyhypusine synthase(DHS)有效抑制剂。真核翻译起始因子5A2 (eIF5A2)是DHS 已知的底物，因此GC7通过抑制DHS 活性来抑制eIF5A2的激活。
T9314	CC214-1	mTOR; Autophagy	Autophagy; PI3K/Akt/mTOR signaling
	CC214-1 是一种 mTOR 抑制剂，具有潜在的抗癌活性，抑制蛋白翻译，可诱导自噬 (autophagy)。 CC214-1 是探索 mTOR 激酶生物学的体外工具化合物，可用于研究骨髓瘤。
T3045	Salubrinal	Apoptosis; Phosphatase; PERK; Autophagy; HSV	Apoptosis; Autophagy; Metabolism; Microbiology/Virology
	Salubrinal 是一种磷酸酶抑制剂，对真核翻译起始因子 2 亚基 (eIF2α) 发挥作用。它作为双特异性磷酸酶 2 抑制剂，抑制抗胶原蛋白抗体诱导的关节炎。它具有抗HSV-1病毒的活性，并抑制由HSV-1蛋白 ICP34.5 介导的eIF2α的去磷酸化。
T3424	Ezutromid BMN 195,VOX-C1100,依珠曲米,SMT C1100	Others	Others
	Ezutromid (BMN 195) 是一种具有口服活性的、首创的苯并恶唑 utrophin 调节剂，EC50=0.91 μM。它抑制人肝微粒体 CYP1A2 酶活性，IC50=5.4 μM。它可用于 Duchenne 型肌营养不良症 (DMD) 的研究。
T12006	Metarrestin ML246	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Metarrestin (ML246) 是一种口服有效的选择性核仁周区室 (PNC) 抑制剂，可有效抑制转移。Metarrestin 破坏核仁结构并抑制 RNA 聚合酶 (Pol) I 转录，部分是通过与翻译延伸因子 eEF1A2 的相互作用。
T12574	PTC299 Emvododstat,(4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate	VEGFR; Dehydrogenase	Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors
	PTC299 ((4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate) 是一种口服活性的 VEGFA mRNA 翻译抑制剂，可选择性地抑制转录后水平的 VEGF 蛋白合成。它还是二氢乳酸脱氢酶 (DHODH) 的有效抑制剂，可研究血液系统恶性肿瘤。
T16550	PKR-IN-C16	Others	Others
	PKR-IN-C16 是一种特异性蛋白激酶抑制剂。它能够抑制 PKR 的自磷酸化，解除 PKR 在原代神经元细胞培养中诱导的翻译阻断。
T63321	20S Proteasome activator 1	Proteasome	Proteases/Proteasome; Ubiquitination
	20S Proteasome activator 1 是一种 20S 蛋白酶激活剂，对胰蛋白酶样位点、胰凝乳蛋白酶样位点和半胱天冬酶位点的 IC50 分别为 0.3 μM、0.7 μM 和 1.8 μM。20S Proteasome activator 1 通过在细胞系统中翻译来防止致病性 α-synuclein A53T 突变体积累从而减少疾病发生的概率。20S Proteasome activator 1 可用于研究神经退行性疾病。
T12916	Silvestrol aglycone	Others	Others
	Silvestrol aglycone is an analogue of Silvestrol, inhibits protein translation initiation in cancer cells(EC50s of 10 and 200 nM for myc-LUC and tub-LUC luciferase reporter protein translation, respectively), with nti-cancer activity.
T33380	MI-389
	MI-389 is a protein degrader, targeting the translation termination factor G1 to S phase transition 1 (GSPT1).
T33511	ms2i6A ms2i6-2-6,ms2i6 2 6
	ms2i6A is a mitochondrial tRNA-specific modification, which regulates efficient mitochondrial translation and energy metabolism in mammals.
T29176	YKL-04-085 YKL 04085,YKL04-085,YKL 04-085,YKL-04085
	YKL-04-085 is a potent inhibitor of viral translation. YKL-04-085 has cellular antiviral activity at 35-fold lower concentrations relative to inhibition of host-cell proliferation. YKL-04-085 demonstrated good inhibition of translation of the DENV2(GVD) r
T70124	Tomivosertib HCl
	Tomivosertib, also known as eFT508 is a MNK1/2 inhibitor. Tomivosertib binds to and inhibits the activity of MNK1 and 2. This prevents MNK1/2-mediated signaling, and inhibits the phosphorylation of certain regulatory proteins, including eukaryotic translation initiation factor 4E (eIF4E), that regulate the translation of messenger RNAs (mRNAs) involved in tumor cell proliferation, angiogenesis, survival and immune signaling.
T21052	Lysidine 2-甲基咪唑啉,2-Methyl-2-iMidazoline	Nucleoside Antimetabolite/Analog	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Lysidine (2-Methyl-2-iMidazoline) 是在 tRNA 之外很少见到的核苷。 Lysidine 具有更好的翻译保真度。
T71810	Thiamphenicol palmitate
	Thiamphenicol palmitate is a Prodrug of Thiamphenicol, inhibiting the 50S subunit of the bacterial ribosome and protein translation.
T10849	CMLD012612	Others	Others
	CMLD012612 is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. It inhibits cell translation and is cytotoxic to NIH/3T3 cells (IC50: 2 nM).
T24512	myomiR-IN-1 myomiR inhibitor-1,myomiR inhibitor 1,myomiRIN1
	myomiR-IN-1 is a myomiRs inhibitor that acts by inhibiting the translation of myoD in C2C12 cells without changing the expression level of myoD mRNA and downregulating the expression of differentiation markers.
T40722	7-Methyl-diguanosine triphosphate 7-Methyl-diguanosine triphosphate,m7Gp3G
	7-Methyl-diguanosine triphosphate (m7Gp3G) is a cap analog that integrates into mRNA, playing a crucial role in translation and mRNA degradation within mammalian cells.
T70752	Neomycin (free base)
	Neomycin (free base) is an antibiotic complex produced by Streptomyces fradiae. It is composed of neomycins A, B, and C. It acts by inhibiting translation during protein synthesis.
T69413	Primordazine B
	Primordazine B is a selective inhibitor of primordial germ cell (PGC) development which targets poly(A)-tail-independent noncanonical translation (PAINT).
T69688	Erythromycin Gluceptate
	Erythromycin Gluceptate is an inhibitor of protein translation and mammalian mRNA splicing. It inhibits growth of gram negative and gram positiove bacteria.
T70696	Erythromycin hydrochloride
	Erythromycin hydrochloride is an inhibitor of protein translation and mammalian mRNA splicing. It inhibits growth of gram negative and gram positiove bacteria.
T10848	CMLD012073	Others	Others
	CMLD012073 is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. It inhibits NIH/3T3 cells (IC50: 10 nM). CMLD012073 inhibits eukaryotic translation initiation by modifying the behavior of the RNA helicase (eIF4A).
T70076	NOSO-95C
	NOSO-95C is an antibacterial compound that bind to the bacterial ribosome and kill bacteria through inhibition of the translation. NOSO-95C showed promising in vitro and in vivo efficacy against Enterobacteriaceae.
T10846	CMLD010509 SDS-1-021	Others	Others
	CMLD010509 (SDS-1-021) is a highly selective inhibitor of the oncogenic translation program supporting multiple myeloma (MM)-including key oncoproteins such as MDM2, CCND1, MYC, MAF, and MCL-1.
T35306	Z-Hpg
	Z-Hpg is a novel bortac-gj enabled selective probe for labeling of nascent proteomes, thus recording translation, in cell networks connected by gap junctions, leaving unconnected cells not labeled
T32126L	Hypusine HCl (+)-Hypusine dihydrochloride,Hypusine dihydrochloride
	Hypusine HCl is an unusual amino acid found in all eukaryotes and in some archaea, but not in bacteria. The only known protein containing hypusine is eukaryotic translation initiation factor 5A (eIF5A) and a similar protein found in archaebacteria.
T28266	Org-6906 Org6906,Org 6906,Org-6906 free
	Tylophorine analog DCB-3503 is a potential anticancer and immunosuppressive agent. DCB-3503 suppresses the translation of cellular regulatory proteins, including cyclin D1, at the elongation step. DCB-3503 allosterically regulates the ATPase and chaperone
T72138	Mitochondrial respiration-IN-2
	Mitochondrial respiration-IN-2 是Virginiamycin M1 的氟衍生物。Mitochondrial respiration-IN-2 可以抑制胶质母细胞瘤干细胞的线粒体翻译。

化合物

eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species]（TFA)

Cat.No: T22774L

Target: Others

Cat.No: T50099

Target: Others, HIF/HIF Prolyl-Hydroxylase

eukaryotic translation initiation factor 3

Cat.No: TP2247

Target: Others

eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species]

Cat.No: T22774

Target: Others

Cat.No: T5331

Target: Antibacterial

Cat.No: T3265

Synonym: Desmethyl Azithromycin,阿奇霉素 A,6-Demethylazithromycin,去甲基阿奇霉素,Azaerythromycin A,Azaerythromycin

Target: Antibacterial, Antibiotic

ATPγS tetralithium salt

Cat.No: T22592

Synonym: ATP-gamma-S tetralithium salt

Target: PERK

Cat.No: T14886

Target: mTOR

Guanosine-5'-triphosphate disodium salt

Cat.No: T11511

Synonym: 5'-GTP disodium salt

Target: Others, Endogenous Metabolite

Cat.No: T13767

Target: Others, Antibacterial

Pyrrolidinedithiocarbamate ammonium

Cat.No: T3147

Synonym: PDTC,Pyrrolidinedithiocarbamate,吡咯烷二硫代氨基甲酸铵,APDC,1-Pyrrolidinedithiocarboxylic acid ammonium salt,Ammonium pyrrolidinedithiocarbamate,吡咯烷二硫代甲酸铵

Target: NF-κB

Cat.No: T4058

Target: Others, Serine/threonin kinase

Cat.No: T28543

Synonym: RK9123016,RK 9123016

Target: Sirtuin

Cat.No: T9980

Target: IGF-1R

Cat.No: T16702

Target: Virus Protease, BTK

Kasugamycin hydrochloride hydrate

Cat.No: T8404

Synonym: Ksg (hydrochloride hydrate),春雷霉素盐酸盐一水合物

Target: Antibacterial, Antibiotic

Cat.No: T3052

Synonym: Bonomycin,Norcycline,Sancyclinum,山环素,6-Demethyl-6-deoxytetracycline

Target: Antibacterial

Cat.No: T4288

Target: VEGFR

N1-Methylpseudouridine

Cat.No: T19459

Synonym: N1-甲基-假尿苷,1-Methylpseudouridine

Target: Others

PF-06446846 hydrochloride

Cat.No: T16491

Target: Others

DMA-135 hydrochloride

Cat.No: T61334

Synonym: DMA-135 HCl

Target: Virus Protease

Cat.No: T11372

Target: Autophagy

Cat.No: T9314

Target: mTOR, Autophagy

Cat.No: T3045

Target: Apoptosis, Phosphatase, PERK, Autophagy, HSV

Cat.No: T3424

Synonym: BMN 195,VOX-C1100,依珠曲米,SMT C1100

Target: Others

Cat.No: T12006

Synonym: ML246

Target: DNA/RNA Synthesis

Cat.No: T12574

Synonym: Emvododstat,(4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate

Target: VEGFR, Dehydrogenase

Cat.No: T16550

Target: Others

20S Proteasome activator 1

Cat.No: T63321

Target: Proteasome

Silvestrol aglycone

Cat.No: T12916

Target: Others

Cat.No: T33380

Cat.No: T33511

Synonym: ms2i6-2-6,ms2i6 2 6

Cat.No: T29176

Synonym: YKL 04085,YKL04-085,YKL 04-085,YKL-04085

Tomivosertib HCl

Cat.No: T70124

Cat.No: T21052

Synonym: 2-甲基咪唑啉,2-Methyl-2-iMidazoline

Target: Nucleoside Antimetabolite/Analog

Thiamphenicol palmitate

Cat.No: T71810

Cat.No: T10849

Target: Others

Cat.No: T24512

Synonym: myomiR inhibitor-1,myomiR inhibitor 1,myomiRIN1

7-Methyl-diguanosine triphosphate

Cat.No: T40722

Synonym: 7-Methyl-diguanosine triphosphate,m7Gp3G

Neomycin (free base)

Cat.No: T70752

Cat.No: T69413

Erythromycin Gluceptate

Cat.No: T69688

Erythromycin hydrochloride

Cat.No: T70696

Cat.No: T10848

Target: Others

Cat.No: T70076

Cat.No: T10846

Synonym: SDS-1-021

Target: Others

Cat.No: T35306

Cat.No: T32126L

Synonym: (+)-Hypusine dihydrochloride,Hypusine dihydrochloride

Cat.No: T28266

Synonym: Org6906,Org 6906,Org-6906 free

Mitochondrial respiration-IN-2

Cat.No: T72138

Cat. No.	Product Name	Target	Signaling Pathways
T16674	Pseudouridine	Endogenous Metabolite	Metabolism
	Pseudouridine 是非编码 RNA 中丰富的修饰核苷，通过稳定 RNA 结构增强核糖体 RNA 和的转移 RNA 功能。
T5429	Theaflavin 3,3'-digallate 茶黄素-3,3'-双没食子酸,8-Gingerol,TFDG	Virus Protease; Antioxidant; HIV Protease; HSV	Microbiology/Virology; oxidation-reduction; Proteases/Proteasome
	Theaflavin 3,3'-digallate (8-Gingerol) 是一种寨卡病毒蛋白酶抑制剂，IC50为 2.3 μM。它直接与 ZIKVpro 结合并抑制 ZIKV 复制，可抑制 gp41 和 NS2B-3 蛋白酶的活性，并具有抗 HSV 和 HIV-1病毒活性。它是红茶中的主要多酚，有抗肿瘤作用。
T3380	Homoharringtonine Myelostat,Ceflatonin,高三尖杉酯碱,HHT,Omacetaxine mepesuccinate	STAT	JAK/STAT signaling; Stem Cells
	Homoharringtonine (HHT) 属于生物碱类天然产物，可以抑制蛋白质的翻译，具有细胞毒性。Homoharringtonine 作用于肿瘤细胞的核糖体，抑制蛋白质翻译的延伸步骤，从而抑制蛋白质合成，具有抗肿瘤活性。
T9715	Aplidine	SARS-CoV; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Aplidine 是有效的eEF1A2(KD=80 nM) 靶向的抗癌药物。Aplidine 具有抗病毒活性，抑制SARS-CoV-2的 IC90为 0.88 nM。Aplidine 在多发性骨髓瘤，晚期癌症及 COVID-19 领域有研究的价值。
T16884	Silvestrol (-)-Silvestrol	Others	Others
	Silvestrol is a eukaryotic translation initiation factor 4A inhibitor. Silvestrol causes autophagy and caspase-mediated apoptosis.
TN4623	Nagilactone C	Antifection	Microbiology/Virology
	Nagilactone C and phyllanthoside are novel protein synthesis inhibitors, they are specific for the eukaryotic translation apparatus, function in vivo and in vitro, and interfere with translation elongation. Nagilactone C shows high insecticidal activity against second-instar nymphs of Eocanthecona furcellata. Nagilactone C possesses potent antiproliferative activity against human fibrosarcoma and murine colon carcinoma tumor cell lines exhibiting ED50 values of 2.3 and 1.2 microg/ml, respectivel...
T11215	Episilvestrol	Others	Others
	Episilvestrol is a specific eIF4A-targeting translation inhibitor, with antitumor activity. Episilvestrol is a derivative of silvestrol, isolated from the fruits and twigs of Aglaia silvestris.
T11534	Haemanthamine	Others	Others
	Haemanthamine is an alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. It inhibits protein biosynthesis during the elongation stage of translation. It has antimalarial, pro-apoptotic, antiviral, antioxidant, and anticonvulsa
T15703	Lactimidomycin	Others	Others
	Lactimidomycin, isolated from Streptomyces, is an inhibitor of eukaryotic translation elongation. It is also a potent and non-toxic inhibitor of dengue virus 2 and other RNA viruses. Lactimidomycin has an antiproliferative effect on tumor cell lines. It i
T35234	Yadanzioside B
	Yadanzioside B 是提取自鸦胆子的苦木素苷类化合物。Yadanzioside B 能够抑制HeLa细胞中的蛋白质合成，但对体外翻译几乎没有影响。
T73813	Haemanthamine hydrochloride
	Haemanthamine hydrochloride 是从Amaryllidaceae 植物中分离出来的一种蛇毒碱样生物碱，具有强大的抗癌活性。Haemanthamine hydrochloride 靶向核糖体以在翻译的延长阶段抑制蛋白质的生物合成。Haemanthamine hydrochloride 具有促凋亡，抗氧化剂，抗病毒，抗疟疾和抗惊厥活性。
T1104	Paromomycin Sulfate Aminosidine sulfate,Paromomycin sulfate salt,硫酸巴龙霉素,巴龙霉素硫酸盐	Antibacterial; Antibiotic; Parasite	Microbiology/Virology
	Paromomycin Sulfate (Aminosidine sulfate) 是一种广谱氨基糖苷类抗生素，是具有杀螨杀菌作用的新霉素衍生物。它通过与细菌 30S 核糖体 A 位点的 RNA 寡核苷酸特异性结合，使 mRNA 的翻译提前终止，并抑制蛋白质合成。它可研究细菌和寄生虫感染。

天然产物

Cat.No: T16674

Target: Endogenous Metabolite

Theaflavin 3,3'-digallate

Cat.No: T5429

Synonym: 茶黄素-3,3'-双没食子酸,8-Gingerol,TFDG

Target: Virus Protease, Antioxidant, HIV Protease, HSV

Homoharringtonine

Cat.No: T3380

Synonym: Myelostat,Ceflatonin,高三尖杉酯碱,HHT,Omacetaxine mepesuccinate

Target: STAT

Cat.No: T9715

Target: SARS-CoV, DNA/RNA Synthesis

Cat.No: T16884

Synonym: (-)-Silvestrol

Target: Others

Cat.No: TN4623

Target: Antifection

Cat.No: T11215

Target: Others

Cat.No: T11534

Target: Others

Cat.No: T15703

Target: Others

Cat.No: T35234

Haemanthamine hydrochloride

Cat.No: T73813

Paromomycin Sulfate

Cat.No: T1104

Synonym: Aminosidine sulfate,Paromomycin sulfate salt,硫酸巴龙霉素,巴龙霉素硫酸盐

Target: Antibacterial, Antibiotic, Parasite

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